+C Two-component system KO
#
Two-Component System - Pseudomonas aeruginosa PA1
%
!
AOmpR family
B PhoR-PhoB (phosphate starvation response)
C PA1S_28960 histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C PA1S_28955 phosphate regulon transcriptional regulatory protein PhoB K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
C PA1S_20000 histidine kinase K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]
C PA1S_20005 transcriptional regulator K07660 phoP; two-component system, OmpR family, response regulator PhoP
B EnvZ-OmpR (osmotic stress response)
C PA1S_28140 ATPase K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C PA1S_28145 chemotaxis protein CheY K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
C PA1S_20110 histidine kinase K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3]
C PA1S_20115 chemotaxis protein CheY K07661 rstA; two-component system, OmpR family, response regulator RstA
B CpxA-CpxR (envelope stress response)
C PA1S_09355 chemotaxis protein CheY K07662 cpxR; two-component system, OmpR family, response regulator CpxR
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
C PA1S_02345 histidine kinase K07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3]
C PA1S_02340 transcriptional regulator K07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB
B BaeS-BaeR (envelope stress response)
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
C PA1S_11420 ATPase K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C PA1S_26530 histidine kinase K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C PA1S_13025 ATPase K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C PA1S_11425 transcriptional regulator K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C PA1S_26525 transcriptional regulator K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C PA1S_13030 transcriptional regulator K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
B QseC-QseB (quorum sensing)
C PA1S_25895 ATPase K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C PA1S_25955 ATPase K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C PA1S_13240 histidine kinase K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C PA1S_25890 regulator K07666 qseB; two-component system, OmpR family, response regulator QseB
C PA1S_25950 regulator K07666 qseB; two-component system, OmpR family, response regulator QseB
C PA1S_13245 transcriptional regulator K07666 qseB; two-component system, OmpR family, response regulator QseB
B KdpD-KdpE (potassium transport)
C PA1S_17835 histidine kinase K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C PA1S_17830 transcriptional regulator K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
B TctE-TctD (tricarboxylic acid transport)
C PA1S_22875 histidine kinase K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]
C PA1S_22880 transcriptional regulator K07774 tctD; two-component system, OmpR family, response regulator TctD
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
C PA1S_16975 ATPase K18072 parS; two-component system, OmpR family, sensor kinase ParS [EC:2.7.13.3]
C PA1S_16970 transcriptional regulator K18073 parR; two-component system, OmpR family, response regulator ParR
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
C PA1S_21770 histidine kinase K19609 pfeS; two-component system, OmpR family, sensor histidine kinase PfeS [EC:2.7.13.3]
C PA1S_12150 histidine kinase K19609 pfeS; two-component system, OmpR family, sensor histidine kinase PfeS [EC:2.7.13.3]
C PA1S_21775 transcriptional regulator K19610 pfeR; two-component system, OmpR family, response regulator PfeR
C PA1S_12155 transcriptional activator protein PfeR K19610 pfeR; two-component system, OmpR family, response regulator PfeR
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C PA1S_09345 histidine kinase K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C PA1S_04320 chemotaxis protein CheY K02483 K02483; two-component system, OmpR family, response regulator
C PA1S_09420 chemotaxis protein CheY K02483 K02483; two-component system, OmpR family, response regulator
C PA1S_12320 transcriptional regulator K02483 K02483; two-component system, OmpR family, response regulator
#
ANarL family
B NarX-NarL (nitrate respiration)
C PA1S_05450 ATPase K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3]
C PA1S_05445 transcriptional regulator K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
C PA1S_13740 transcriptional regulator K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
B NarQ-NarP (nitrate respiration)
B UhpB-UhpA (hexose phosphates uptake)
C PA1S_15800 multidrug MFS transporter K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
C PA1S_06525 LuxR family transcriptional regulator K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
C PA1S_04430 LuxR family transcriptional regulator K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
C PA1S_10915 LuxR family transcriptional regulator K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
B BarA-UvrY (central carbon metabolism)
C PA1S_21780 chemotaxis protein CheY K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]
C PA1S_12680 chemotaxis protein CheY K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
C PA1S_05100 chemotaxis protein CheY K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
C PA1S_12700 chemotaxis protein CheY K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
C PA1S_00175 LuxR family transcriptional regulator K07690 evgA; two-component system, NarL family, response regulator EvgA
C PA1S_05090 LuxR family transcriptional regulator K07690 evgA; two-component system, NarL family, response regulator EvgA
C PA1S_10160 LuxR family transcriptional regulator K07690 evgA; two-component system, NarL family, response regulator EvgA
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
C PA1S_23350 ATPase K27076 pprA; two-component system, NarL family, sensor histidine kinase PprA [EC:2.7.13.3]
C PA1S_23365 LuxR family transcriptional regulator K27077 pprB; two-component system, NarL family, response regulator PprB
B Unclassified
#
ASpo family
B KinABCDE-Spo0FA (sporulation control)
#
ACitB family
B CitA-CitB (citrate fermentation)
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
#
ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
C PA1S_28460 alginate O-acetyltransferase K08082 algZ; two-component system, LytTR family, sensor histidine kinase AlgZ [EC:2.7.13.3]
C PA1S_28455 chemotaxis protein CheY K08083 algR; two-component system, LytTR family, response regulator AlgR
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
#
ANtrC family
B GlnL-GlnG (nitrogen regulation)
C PA1S_27740 histidine kinase K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]
C PA1S_27745 glnG; nitrogen regulation protein NR(I) K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
C PA1S_25630 Fis family transcriptional regulator K07713 zraR; two-component system, NtrC family, response regulator HydG
B AtoS-AtoC (cPHB biosynthesis)
B PilS-PilR (type 4 fimbriae synthesis)
C PA1S_24655 histidine kinase K02668 pilS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3]
C PA1S_24660 transcriptional regulator K02667 pilR; two-component system, NtrC family, response regulator PilR
B GlrK-GlrR (amino sugar metabolism)
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
C PA1S_27965 ATPase K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]
C PA1S_29750 cytochrome C biogenesis protein CcmE K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]
C PA1S_27970 Fis family transcriptional regulator K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
C PA1S_29745 C4-dicarboxylate ABC transporter K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
B KinB-AlgB (alginate production)
C PA1S_29610 histidine kinase K11383 kinB; two-component system, NtrC family, sensor histidine kinase KinB [EC:2.7.13.3]
C PA1S_29605 chemotaxis protein CheY K11384 algB; two-component system, NtrC family, response regulator AlgB
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
C PA1S_12765 ATPase K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
#
ACheA family
B CheA-CheYBV (chemotaxis)
C PA1S_00930 chemotaxis protein CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C PA1S_18740 chemotaxis protein CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C PA1S_00935 Fis family transcriptional regulator K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C PA1S_18750 histidine kinase K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C PA1S_00905 chemotaxis protein K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C PA1S_18735 chemotaxis protein CheY K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C PA1S_08600 chemotaxis protein CheW K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
B ChpA-ChpB/PilGH (chemosensory)
C PA1S_02095 chemotaxis protein CheA K06596 chpA; chemosensory pili system protein ChpA (sensor histidine kinase/response regulator)
C PA1S_02070 pilus assembly protein PilG K02657 pilG; twitching motility two-component system response regulator PilG
C PA1S_02075 chemotaxis protein CheY K02658 pilH; twitching motility two-component system response regulator PilH
C PA1S_02100 chemotaxis protein CheB K06597 chpB; chemosensory pili system protein ChpB (putative protein-glutamate methylesterase)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
C PA1S_06575 chemotaxis protein CheA K13490 wspE; two-component system, chemotaxis family, sensor histidine kinase and response regulator WspE
C PA1S_06585 diguanylate cyclase K11444 wspR; two-component system, chemotaxis family, response regulator WspR [EC:2.7.7.65]
C PA1S_06580 chemotaxis protein K13491 wspF; two-component system, chemotaxis family, response regulator WspF [EC:3.1.1.61]
B Cph1-Rcp1 (light response)
#
ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
#
ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
#
ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
C PA1S_03840 LuxR family transcriptional regulator K14987 fixJ; two-component system, LuxR family, response regulator FixJ
B SsrA-SsrB
#
AOther families
B FlrB-FlrC (polar flagellar synthesis)
C PA1S_20405 histidine kinase K10942 flrB; two-component system, sensor histidine kinase FlrB [EC:2.7.13.3]
C PA1S_20400 Fis family transcriptional regulator K10943 flrC; two-component system, response regulator FlrC
B AauS-AauR (acidic amino acids utilization)
C PA1S_19225 histidine kinase K17060 aauS; two-component system, sensor histidine kinase AauS [EC:2.7.13.3]
C PA1S_19230 Fis family transcriptional regulator K17061 aauR; two-component system, response regulator AauR
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
C PA1S_24370 histidine kinase K15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3]
C PA1S_24365 chemotaxis protein CheY K15012 regA; two-component system, response regulator RegA
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
C PA1S_11295 histidine kinase K20973 sagS; two-component system, sensor histidine kinase SagS [EC:2.7.13.3]
C PA1S_17960 histidine kinase K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]
C PA1S_15815 ATPase K20975 K20975; two-component system, sensor histidine kinase [EC:2.7.13.3]
C PA1S_08620 histidine kinase K20976 hptB; histidine phosphotransfer protein HptB
C PA1S_21015 histidine phosphotransferase K20976 hptB; histidine phosphotransfer protein HptB
C PA1S_08615 chemotaxis protein CheY K20977 hsbR; two-component system, HptB-dependent secretion and biofilm response regulator
B PdtaS-PdtaR
B NasS-NasT
C PA1S_17065 nitrate transporter K22067 nasS; two-component system, oxyanion-binding sensor
C PA1S_17070 histidine kinase K07183 nasT; two-component system, response regulator / RNA-binding antiterminator
C PA1S_08530 aliphatic amidase regulator K07183 nasT; two-component system, response regulator / RNA-binding antiterminator
B Unclassified
C PA1S_04955 histidine kinase K20971 ladS; two-component system, sensor histidine kinase LadS
C PA1S_26380 histidine kinase K20972 retS; two-component system, sensor histidine kinase RetS
!
#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023