+E Messenger RNA Biogenesis KO
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Messenger RNA Biogenesis - Scheffersomyces stipitis
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AEukaryotic type
B mRNA processing factors
C 5' end processing
D Capping factors
E PICST_66228 ABD1; mRNA cap methyltransferase K00565 RNMT; mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56]
E PICST_90135 CDC28; cell division control protein K04563 CDC28; cyclin-dependent kinase [EC:2.7.11.22]
E PICST_54142 KIN28; serine-threonine kinase, subunit of RNA Pol TFIIK K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E PICST_34053 CEG1; mRNA capping enzyme alpha subunit and guanylyltransferase K00987 CEG1; mRNA guanylyltransferase [EC:2.7.7.50]
E PICST_82650 predicted protein K01098 CET1; polynucleotide 5'-triphosphatase [EC:3.6.1.74]
D Cap binding complex
E PICST_65304 GCR3; GCR3 protein K12882 NCBP1; nuclear cap-binding protein subunit 1
E PICST_37507 CBC2; small subunit of the nuclear mRNA cap-binding protein complex CBC K12883 NCBP2; nuclear cap-binding protein subunit 2
C 3' end processing
D Pre-mRNA cleavage factor Im (CFIm)
D Pre-mRNA cleavage factor IIm (CFIIm)
E PICST_55332 predicted protein K14399 CLP1; polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78]
E PICST_89727 pre-mRNA cleavage and polyadenylation factor I subunit K14400 PCF11; pre-mRNA cleavage complex 2 protein Pcf11
E PICST_31270 PCF11; pre-mRNA cleavage and polyadenylation factor I component K14400 PCF11; pre-mRNA cleavage complex 2 protein Pcf11
D Cleavage and polyadenylation specificity factor (CPSF) complex
E PICST_52034 CFT1; pre-mRNA 3'-end processing factor CF II mRNA cleavage and polyadenylation factor II complex, subunit CFT1 (CPSF subunit) RNA processing and modification K14401 CPSF1; cleavage and polyadenylation specificity factor subunit 1
E PICST_81097 predicted protein K14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2
E PICST_89936 predicted protein K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
E PICST_27265 cleavage and polyadenylation specificity factor K14404 CPSF4; cleavage and polyadenylation specificity factor subunit 4
E PICST_32232 FIP1; component of a pre-mRNA polyadenylation factor K14405 FIP1L1; pre-mRNA 3'-end-processing factor FIP1
E PICST_28531 MPE1; conserved zinc finger protein required for cell viability K15541 MPE1; protein MPE1
E PICST_51666 PFS2; polyadenylation factor I subunit 2 K15542 PFS2; polyadenylation factor subunit 2
E PICST_62019 SWD2; member of Set1p complex, histone methyl transferase K14962 WDR82; COMPASS component SWD2
E PICST_85252 GLC7; protein phosphatase type I K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
E PICST_61419 predicted protein K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
E PICST_43575 predicted protein K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
E PICST_30447 predicted protein K15544 SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16]
D Cleavage stimulation factor (CSTF) complex
E PICST_44112 predicted protein K14407 CSTF2; cleavage stimulation factor subunit 2
E PICST_48462 predicted protein K14407 CSTF2; cleavage stimulation factor subunit 2
E PICST_31379 predicted protein K14408 CSTF3; cleavage stimulation factor subunit 3
E PICST_45999 predicted protein K06100 SYMPK; symplekin
D U7-dependent histone pre-mRNA processing factors
E PICST_32971 predicted protein K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E PICST_13887 predicted protein K11088 SNRPD3; small nuclear ribonucleoprotein D3
E PICST_47366 predicted protein K11097 SNRPE; small nuclear ribonucleoprotein E
E PICST_46368 predicted protein K11098 SNRPF; small nuclear ribonucleoprotein F
E PICST_81097 predicted protein K14402 CPSF2; cleavage and polyadenylation specificity factor subunit 2
E PICST_89936 predicted protein K14403 CPSF3; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
E PICST_44112 predicted protein K14407 CSTF2; cleavage stimulation factor subunit 2
E PICST_48462 predicted protein K14407 CSTF2; cleavage stimulation factor subunit 2
E PICST_45999 predicted protein K06100 SYMPK; symplekin
D DRB sensitivity inducing factor (DSIF) complex
E PICST_40336 predicted protein K15171 SUPT4H1; transcription elongation factor SPT4
E PICST_70551 transcription initiation protein SPT5 K15172 SUPT5H; transcription elongation factor SPT5
D N6-methyltransferase complex
E PICST_57562 IME4; activator of IME1 Predicted N6-adenine RNA methylase IME4 K05925 METTL3; mRNA m6A methyltransferase catalytic subunit [EC:2.1.1.348]
E PICST_35413 predicted protein K23960 METTL14; mRNA m6A methyltransferase non-catalytic subunit
D Poly(A) addition factors
E PICST_85400 PAP1; Poly(A) polymerase PAPalpha (Polynucleotide adenylyltransferase alpha) K14376 PAP; poly(A) polymerase [EC:2.7.7.19]
D Negative regulators of mRNA 3' end processing
C Other processing factors
D PICST_49415 predicted protein K13102 KIN; DNA/RNA-binding protein KIN17
D PICST_80143 NAB2; polyadenylated RNA binding protein K23039 NAB2; nuclear polyadenylated RNA-binding protein NAB2
B mRNA surveillance and transport factors
C Transport factors
D EJC complex
E PICST_81261 RNA annealing protein K12881 THOC4; THO complex subunit 4
E PICST_35114 predicted protein K12881 THOC4; THO complex subunit 4
E PICST_83587 SUB2; Suppressor of the cold-sensitive snRNP biogenesis mutant brr1-1 K12812 DDX39B; ATP-dependent RNA helicase UAP56/SUB2 [EC:5.6.2.7]
E PICST_52941 FAL1; RNA helicase involved in maturation of 18S rRNA K13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]
E PICST_63288 RBM25; Probable RNA-binding protein K13171 SRRM1; serine/arginine repetitive matrix protein 1
D TREX complex
E PICST_58253 RLR1; THO2 plays a role in transcriptional elongation K12879 THOC2; THO complex subunit 2
E PICST_49400 predicted protein K12880 THOC3; THO complex subunit 3
E PICST_81261 RNA annealing protein K12881 THOC4; THO complex subunit 4
E PICST_35114 predicted protein K12881 THOC4; THO complex subunit 4
E PICST_37730 hypothetical protein K18712 HPR1; THO complex subunit HPR1
D TREX-2 complex
E PICST_81567 predicted protein K23801 PCID2; nuclear mRNA export protein PCID2/THP1
E PICST_34019 predicted protein K10881 SHFM1; 26 proteasome complex subunit DSS1
E PICST_50963 spindle pole body calcium-binding protein component K16466 CETN3; centrin-3
E PICST_59295 SAC3; protein involved in processes affecting the actin cytoskeleton and mitosis K23719 SAC3; nuclear mRNA export protein SAC3
D Nuclear pore complex
E PICST_77577 nuclear pore protein K14298 RAE1; mRNA export factor
E PICST_76043 protein transport factor K14004 SEC13; protein transport protein SEC13
E PICST_34582 NUP85; Protein in nuclear pore complex may function in nuclear envelope integrity may also be involved in tRNA biogenesis K14304 NUP85; nuclear pore complex protein Nup85
E PICST_82631 predicted protein K14308 NUP54; nuclear pore complex protein Nup54
E PICST_88123 NSP1; Nucleoporin NSP1 (Nuclear pore protein NSP1) (Nucleoskeletal-like protein) (p110) K14306 NUP62; nuclear pore complex protein Nup62
E PICST_76301 predicted protein K14309 NUP93; nuclear pore complex protein Nup93
E PICST_42583 NUP116; nuclear pore protein K14297 NUP98; nuclear pore complex protein Nup98-Nup96
E PICST_31476 NUP84; Nucleoporin NUP84 (Nuclear pore protein NUP84) K14301 NUP107; nuclear pore complex protein Nup107
E PICST_66409 NUP133; Nuclear pore complex protein involved in poly(A)+ RNA transport, nuclear pore distribution, and possibly in the biogenesis of functional tRNA K14300 NUP133; nuclear pore complex protein Nup133
E PICST_40727 NUP188; nucleoporin K14311 NUP188; nuclear pore complex protein Nup188
E PICST_66374 NUP170; nuclear pore complex subunit K14312 NUP155; nuclear pore complex protein Nup155
E PICST_80698 NUP120; nuclear pore protein K14303 NUP160; nuclear pore complex protein Nup160
E PICST_30874 predicted protein K14310 NUP205; nuclear pore complex protein Nup205
E PICST_66703 NUP49; Nucleoporin NUP49/NSP49 (Nuclear pore protein NUP49/NSP49) K14307 NUPL1; nucleoporin p58/p45
E PICST_83864 NDC1; nuclear envelope protein K14315 NDC1; nucleoporin NDC1
E PICST_60243 predicted protein K14299 SEH1; nucleoporin SEH1
E PICST_80670 NUP159; nuclear pore protein K18715 NUP159; nucleoporin NUP159
E PICST_66612 predicted protein K18716 NUP42; nucleoporin NUP42
E PICST_56883 predicted protein K18717 ASM4; nucleoporin ASM4
E PICST_67388 predicted protein K18718 NUP60; nucleoporin NUP60
E PICST_76708 NUP82; nuclear pore protein K18719 NUP82; nucleoporin NUP82
E PICST_80553 NUP145; Nucleoporin NUP145 precursor (Nuclear pore protein NUP145) Contains: Nucleoporin NUP145N (N-NUP145) Nucleoporin NUP145C (C-NUP145) K18720 NUP145; nucleoporin NUP145
E PICST_82669 NSP2; Nucleoskeletal protein K18721 NUP1; nucleoporin NUP1
E PICST_83705 NUP4; nuclear pore protein K18722 NUP2; nucleoporin NUP2
E PICST_50963 spindle pole body calcium-binding protein component K16466 CETN3; centrin-3
E PICST_33173 predicted protein K18723 GLE1; nucleoporin GLE1
E PICST_85667 MEX67; nuclear mRNA export, poly(A)+RNA binding protein K14284 NXF; nuclear RNA export factor
E PICST_36980 predicted protein K14543 MTR2; mRNA transport regulator MTR2
E PICST_31254 predicted protein K18724 POM34; nucleoporin POM34
E PICST_41690 predicted protein K18725 POM152; nucleoporin POM152
E PICST_30847 predicted protein K14017 SNL1; HSP70 co-chaperone SNL1
D Ran-mediated transport factors
E PICST_84260 predicted protein K07936 RAN; GTP-binding nuclear protein Ran
E PICST_43666 predicted protein K18726 FAF2; FAS-associated factor 2
E PICST_67138 CDC48; Cell division control protein 48 K13525 VCP; transitional endoplasmic reticulum ATPase
E PICST_86741 chromosome region maintenance protein 1 K14290 XPO1; exportin-1
E PICST_81269 predicted protein K14319 RANGAP1; Ran GTPase-activating protein 1
E PICST_85825 predicted protein K14651 TAF15; transcription initiation factor TFIID subunit 15
D eIF4F and regulatory proteins
E PICST_81210 predicted protein K03259 EIF4E; translation initiation factor 4E
E PICST_74636 TIF1; Eukaryotic initiation factor 4A (eIF4A) (eIF-4A) K03257 EIF4A; translation initiation factor 4A
E PICST_17868 IF4F1; Eukaryotic initiation factor 4F subunit p150 (eIF4F p150) (eIF-4F p150) (mRNA cap-binding protein complex subunit p150) K03260 EIF4G; translation initiation factor 4G
E PICST_67602 TIF4631; mRNA cap binding protein eIF 4F K03260 EIF4G; translation initiation factor 4G
E PICST_84007 predicted protein K03258 EIF4B; translation initiation factor 4B
E PICST_55603 DED1; ATP-dependent RNA helicase of DEAD box family K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]
E PICST_66248 SMY2; kinesin-like protein K18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein
E PICST_90501 PAB1; Polyadenylate-binding protein, cytoplasmic and nuclear (Poly(A)-binding protein) (PABP) (ARS consensus binding protein ACBP-67) (Polyadenylate tail-binding protein) K13126 PABPC; polyadenylate-binding protein
E PICST_85287 predicted protein K12599 SKI2; antiviral helicase SKI2 [EC:5.6.2.6]
E PICST_54312 SLH1; DNA-directed DNA polymerase K18664 SLH1; antiviral helicase SLH1 [EC:5.6.2.6]
E PICST_53664 predicted protein K07575 MCTS; malignant T-cell-amplified sequence
E PICST_59087 predicted protein K24272 DENR; density-regulated protein
D APOBEC1-ACF complex
D Other transport factors
E PICST_68431 nuclear polyadenylated RNA-binding protein 4 K14411 MSI; RNA-binding protein Musashi
E PICST_48738 predicted protein K14416 HBS1; elongation factor 1 alpha-like protein
E PICST_42885 predicted protein K06965 PELO; protein pelota
E PICST_50467 predicted protein K14396 PABPN1; polyadenylate-binding protein 2
E PICST_45495 predicted protein K14396 PABPN1; polyadenylate-binding protein 2
E PICST_53355 DBP5; RNA helicase required for poly(A+) mRNA export K18655 DDX19; ATP-dependent RNA helicase DDX19/DBP5 [EC:5.6.2.7]
E PICST_51927 predicted protein K12867 SYF1; pre-mRNA-splicing factor SYF1
E PICST_22536 predicted protein K18732 SARNP; SAP domain-containing ribonucleoprotein
E PICST_65479 PRP20; pheromone response pathway K11493 RCC1; regulator of chromosome condensation
E PICST_30329 LPR1; Leucine permease transcriptional regulator K23802 LENG8; SAC3 family protein LENG8/THP3
C Surveillance factors
D Surveillance complex
E PICST_80337 SUP45; transcriptional release factor (ERF1) K03265 ETF1; peptide chain release factor subunit 1
E PICST_83594 ERF2; elongation release factor K03267 ERF3; peptide chain release factor subunit 3
E PICST_81669 NMD2; protein involved in decay of mRNA containing nonsense codons K14327 UPF2; regulator of nonsense transcripts 2
E PICST_67017 predicted protein K14328 UPF3; regulator of nonsense transcripts 3
D Protein phosphatase 2A
E PICST_81790 predicted protein K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
E PICST_81383 predicted protein K03456 PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
E PICST_65430 CDC55; Protein phosphatase PP2A regulatory subunit B (PR55) (Cell division control protein 55) K04354 PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
E PICST_84038 predicted protein K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
D Other surveillance factors
E PICST_66248 SMY2; kinesin-like protein K18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein
C Factors involved in mRNA localization
D Cargo complex
E PICST_62098 SHE3; mother-specific HO expression K18737 SHE3; SWI5-dependent HO expression protein 3
E PICST_80365 PUF6; pumilio-family RNA binding domain-containing protein K14844 PUF6; pumilio homology domain family member 6
E PICST_62156 predicted protein K18738 HEK; heterogeneous nuclear rnp K-like protein
E PICST_76889 PBP2; PAB1 binding protein K18738 HEK; heterogeneous nuclear rnp K-like protein
E PICST_75361 MYO2; Myosin-2 (Class V unconventional myosin MYO2) (Type V myosin heavy chain MYO2) (Myosin V MYO2) K10357 MYO5; myosin V
E PICST_66069 ASH1; GATA-type transcription factor K18658 ASH1; transcriptional regulatory protein ASH1
D Factors that have mRNA localization signals
D Trans-acting binding proteins
E PICST_65303 TEF1; Elongation factor 1-alpha (EF-1-alpha) K03231 EEF1A; elongation factor 1-alpha
E PICST_77514 TEF3; translational elongation factor EF-1 alpha K03231 EEF1A; elongation factor 1-alpha
E PICST_88081 TEF4; elongation factor 1 gamma domain-containing protein K03233 EEF1G; elongation factor 1-gamma
D Other mRNA localization factors
E PICST_82373 SSD1; Exosomal 3'-5' exoribonuclease complex, subunit Rrp44/Dis3 K18748 SSD1; protein SSD1
C mRNA cycle factors
D Common to processing body (P body) and stress granule
E PICST_81210 predicted protein K03259 EIF4E; translation initiation factor 4E
E PICST_55603 DED1; ATP-dependent RNA helicase of DEAD box family K11594 DDX3X; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]
E PICST_90571 DHH1; RNA helicase of DEAD box family K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7]
E PICST_76526 multicopy suppressor of clathrin deficiency K18749 LSM14; protein LSM14
E PICST_80310 putative importin, protein K18752 TNPO1; transportin-1
E PICST_28862 GHL2; ATP-dependent RNA helicase K18754 LIN28; protein lin-28
E PICST_68202 TPK2; cAMP-dependent protein kinase catalytic subunit K04345 PKA; protein kinase A [EC:2.7.11.11]
E PICST_70266 camp-dependent protein kinase K04345 PKA; protein kinase A [EC:2.7.11.11]
D P-body specific factors
E PICST_68309 predicted protein K12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]
E PICST_52382 DCP1; decapping protein involved in mRNA Degradation K12612 DCP1; mRNA-decapping enzyme subunit 1
E PICST_68190 predicted protein K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1
E PICST_50259 LSM2; snRNA-associated protein, Sm class K12621 LSM2; U6 snRNA-associated Sm-like protein LSm2
E PICST_63621 predicted protein K12622 LSM3; U6 snRNA-associated Sm-like protein LSm3
E PICST_54497 predicted protein K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4
E PICST_23784 predicted protein K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5
E PICST_46810 predicted protein K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7
E PICST_75361 MYO2; Myosin-2 (Class V unconventional myosin MYO2) (Type V myosin heavy chain MYO2) (Myosin V MYO2) K10357 MYO5; myosin V
E PICST_89181 TUB1; Tubulin alpha chain K07374 TUBA; tubulin alpha
E PICST_65421 predicted protein K12604 CNOT1; CCR4-NOT transcription complex subunit 1
E PICST_34119 CDC36; transcriptional regulator involved in cell cycle regulation K12605 CNOT2; CCR4-NOT transcription complex subunit 2
E PICST_75782 NOT5; negative transcriptional regulator K12580 CNOT3; CCR4-NOT transcription complex subunit 3
E PICST_41699 general negative regulator of transcription K12580 CNOT3; CCR4-NOT transcription complex subunit 3
E PICST_79785 NOT4; transcriptional repressor general negative regulator of transcription subunit 4 K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
E PICST_55298 CCR4; Glucose-repressible alcohol dehydrogenase transcriptional effector (Cytoplasmic deadenylase) (Carbon catabolite repressor protein 4) K12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]
E PICST_88664 predicted protein K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8
E PICST_88597 predicted protein K12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]
E PICST_76360 component of Pab1p-stimulated poly(A) ribonuclease K12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3
E PICST_80647 PAT1; topoisomerase II- associated protein K12617 PATL1; DNA topoisomerase 2-associated protein PAT1
E PICST_67536 predicted protein K18759 EDC1_2; enhancer of mRNA-decapping protein 1/2
E PICST_52834 predicted protein K12615 EDC3; enhancer of mRNA-decapping protein 3
E PICST_81669 NMD2; protein involved in decay of mRNA containing nonsense codons K14327 UPF2; regulator of nonsense transcripts 2
E PICST_67017 predicted protein K14328 UPF3; regulator of nonsense transcripts 3
E PICST_28240 RPB7; RNA polymerase II subunit K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
E PICST_49700 uncharacterized conserved hypothetical protein K20102 YTHDF; YTH domain-containing family protein
D Stress granule specific factors
E PICST_55837 polyadenylated RNA-binding protein K13201 TIA1; nucleolysin TIA-1/TIAR
E PICST_90501 PAB1; Polyadenylate-binding protein, cytoplasmic and nuclear (Poly(A)-binding protein) (PABP) (ARS consensus binding protein ACBP-67) (Polyadenylate tail-binding protein) K13126 PABPC; polyadenylate-binding protein
E PICST_88690 predicted protein K15026 EIF2A; translation initiation factor 2A
E PICST_73391 translation initiation factor eIF3 subunit K03253 EIF3B; translation initiation factor 3 subunit B
E PICST_74636 TIF1; Eukaryotic initiation factor 4A (eIF4A) (eIF-4A) K03257 EIF4A; translation initiation factor 4A
E PICST_52941 FAL1; RNA helicase involved in maturation of 18S rRNA K13025 EIF4A3; ATP-dependent RNA helicase [EC:5.6.2.7]
E PICST_84007 predicted protein K03258 EIF4B; translation initiation factor 4B
E PICST_17868 IF4F1; Eukaryotic initiation factor 4F subunit p150 (eIF4F p150) (eIF-4F p150) (mRNA cap-binding protein complex subunit p150) K03260 EIF4G; translation initiation factor 4G
E PICST_67602 TIF4631; mRNA cap binding protein eIF 4F K03260 EIF4G; translation initiation factor 4G
E PICST_46672 ASC1; WD repeat protein K14753 RACK1; guanine nucleotide-binding protein subunit beta-2-like 1 protein
E PICST_85667 MEX67; nuclear mRNA export, poly(A)+RNA binding protein K14284 NXF; nuclear RNA export factor
E PICST_71431 histone deacetylase A K11407 HDAC6; histone deacetylase 6 [EC:3.5.1.98]
B mRNA degradation factors
C 5'-3' decay
D Decapping complex
E PICST_52382 DCP1; decapping protein involved in mRNA Degradation K12612 DCP1; mRNA-decapping enzyme subunit 1
E PICST_68309 predicted protein K12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]
E PICST_90571 DHH1; RNA helicase of DEAD box family K12614 DDX6; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7]
E PICST_67536 predicted protein K18759 EDC1_2; enhancer of mRNA-decapping protein 1/2
E PICST_52834 predicted protein K12615 EDC3; enhancer of mRNA-decapping protein 3
E PICST_80647 PAT1; topoisomerase II- associated protein K12617 PATL1; DNA topoisomerase 2-associated protein PAT1
D Lsm complex
E PICST_68190 predicted protein K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1
E PICST_50259 LSM2; snRNA-associated protein, Sm class K12621 LSM2; U6 snRNA-associated Sm-like protein LSm2
E PICST_63621 predicted protein K12622 LSM3; U6 snRNA-associated Sm-like protein LSm3
E PICST_54497 predicted protein K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4
E PICST_23784 predicted protein K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5
E PICST_46810 predicted protein K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7
D 5' exonucleases
D Other 5'-3' decay factors
E PICST_46357 trehalase-associated protein K12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59]
C 3'-5' decay
D Core exosome factors
E PICST_84802 CSL4; exosome 3'->5 exonuclease subunit ski4 (Csl4) K07573 CSL4; exosome complex component CSL4
E PICST_31470 predicted protein K03679 RRP4; exosome complex component RRP4
E PICST_34164 RRP40; exosome complex component RRP40 K03681 RRP40; exosome complex component RRP40
E PICST_38006 3'->5' exoribonuclease K11600 RRP41; exosome complex component RRP41
E PICST_32283 RRP46; Exosome complex exonuclease RRP46 (Ribosomal RNA processing protein 46) K12590 RRP46; exosome complex component RRP46
E PICST_57180 MTR3; exosome exoribonuclease K12587 MTR3; exosome complex component MTR3
E PICST_43184 predicted protein K12589 RRP42; exosome complex component RRP42
E PICST_70277 ribosomal RNA processing K12586 RRP43; exosome complex component RRP43
E PICST_59559 predicted protein K03678 RRP45; exosome complex component RRP45
D Exosome cofactors
E PICST_86849 DIS3; 3'-5' exoribonuclease required for 3 end formation of 5.8S rRNA K12585 DIS3; exosome complex exonuclease DIS3/RRP44 [EC:3.1.13.-]
E PICST_68661 RRP6; exosome component 3'-5' exonuclease K12591 RRP6; exosome complex exonuclease RRP6 [EC:3.1.13.-]
E PICST_61936 predicted protein K12592 C1D; exosome complex protein LRP1
E PICST_28847 predicted protein K12594 MPP6; M-phase phosphoprotein 6, fungi type
D TRAMP complex
E PICST_52420 TRF4; topoisomerase I-related protein K03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5/7 [EC:2.7.7.19]
E PICST_55340 arginine methyltransferase-interacting RING finger protein K12597 AIR1_2; protein AIR1/2
E PICST_36809 MTR4; Dead-box family helicase required for mRNA export from nucleus K12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6]
D Ski complex
E PICST_85287 predicted protein K12599 SKI2; antiviral helicase SKI2 [EC:5.6.2.6]
E PICST_43936 SKI3; antiviral protein K12600 SKI3; superkiller protein 3
E PICST_57545 predicted protein K12601 SKI8; superkiller protein 8
D Ccr4-NOT complex
E PICST_55298 CCR4; Glucose-repressible alcohol dehydrogenase transcriptional effector (Cytoplasmic deadenylase) (Carbon catabolite repressor protein 4) K12603 CNOT6; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]
E PICST_65421 predicted protein K12604 CNOT1; CCR4-NOT transcription complex subunit 1
E PICST_34119 CDC36; transcriptional regulator involved in cell cycle regulation K12605 CNOT2; CCR4-NOT transcription complex subunit 2
E PICST_75782 NOT5; negative transcriptional regulator K12580 CNOT3; CCR4-NOT transcription complex subunit 3
E PICST_41699 general negative regulator of transcription K12580 CNOT3; CCR4-NOT transcription complex subunit 3
E PICST_79785 NOT4; transcriptional repressor general negative regulator of transcription subunit 4 K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
E PICST_88664 predicted protein K12581 CNOT7_8; CCR4-NOT transcription complex subunit 7/8
E PICST_30991 CAF40; Cell differentiation protein K12606 RCD1; CCR4-NOT transcription complex subunit 9
E PICST_70378 ATP-binding cassette transporter activity K12608 CAF16; CCR4-NOT complex subunit CAF16
E PICST_53693 predicted protein K12609 CAF120; CCR4-NOT transcriptional complex subunit CAF120
D Pan complex
E PICST_88597 predicted protein K12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]
E PICST_76360 component of Pab1p-stimulated poly(A) ribonuclease K12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3
D Other 3'-5' decay factors
E PICST_46357 trehalase-associated protein K12584 DCPS; m7GpppX diphosphatase [EC:3.6.1.59]
E PICST_65878 predicted protein K27407 VTS1; RNA-binding protein VTS1
C Other degradation factors
D RNases
#
AProkaryotic type
B Bacterial mRNA degradation factors
C RNA degradosome components
D Ribonucreases
E PICST_30953 predicted protein K03685 rnc; ribonuclease III [EC:3.1.26.3]
E PICST_57408 predicted protein K13288 orn; oligoribonuclease [EC:3.1.-.-]
D Helicases
D Other RNA degradosome components
E PICST_70720 ENO1; enolase I K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
E PICST_66973 PFK2; 6-phosphofructokinase beta subunit (Phosphofructokinase 2) (Phosphohexokinase) (6PF-1-K beta subunit) (CaPFK2) K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
E PICST_70563 PFK1; 6-phosphofructokinase, alpha subunit K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
C Other RNA degradation factors
D Chaperones
E PICST_78689 SSC1.2; mitochondrial heat shock protein of the HSP70 family upregulated 15 fold under aerobic conditions K04043 dnaK; molecular chaperone DnaK
E PICST_87680 SSC1.1; Nuclear-encoded mitochondrial protein member of the heat shock protein 70 (HSP70) family K04043 dnaK; molecular chaperone DnaK
E PICST_90190 mitochondrial groEL-type heat shock protein K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D Others
D Bacterial Small RNA Regulators
B Archeal mRNA degradation factors
C Exosome components
D Core exosome
E PICST_31470 predicted protein K03679 RRP4; exosome complex component RRP4
E PICST_84802 CSL4; exosome 3'->5 exonuclease subunit ski4 (Csl4) K07573 CSL4; exosome complex component CSL4
D Cofactors
E PICST_38006 3'->5' exoribonuclease K11600 RRP41; exosome complex component RRP41
E PICST_43184 predicted protein K12589 RRP42; exosome complex component RRP42
D Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: April 25, 2024