+E Replication protein KO
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DNA Replication Proteins - Xenopus tropicalis (tropical clawed frog)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 734048 orc1; origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D 780267 orc2; origin recognition complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D 100125181 orc3; origin recognition complex subunit 3 K02605 ORC3; origin recognition complex subunit 3
D 448135 orc4; origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D 549767 orc5; origin recognition complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D 549939 orc6; origin recognition complex subunit 6 K02608 ORC6; origin recognition complex subunit 6
D 100379812 cdt1; DNA replication factor Cdt1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 493356 cdc6; cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 448458 mcm2; DNA replication licensing factor mcm2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 734092 mcm3; zygotic DNA replication licensing factor mcm3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 100158601 mcm3; maternal DNA replication licensing factor mcm3 isoform X2 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 448137 mcm4; DNA replication licensing factor mcm4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 550081 mcm5; DNA replication licensing factor mcm5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 395030 mcm6.2; zygotic DNA replication licensing factor mcm6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 548975 mcm6; maternal DNA replication licensing factor mcm6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 407945 mcm7; DNA replication licensing factor mcm7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 448454 ccna2; cyclin-A2 K06627 CCNA; cyclin-A
D 548993 ccna1; cyclin-A1 K06627 CCNA; cyclin-A
D 549082 ccne1; G1/S-specific cyclin-E1 K06626 CCNE; G1/S-specific cyclin-E1
D 549021 ccne2; G1/S-specific cyclin-E2 K06626 CCNE; G1/S-specific cyclin-E1
D 493498 cdk2; cyclin-dependent kinase 2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 549335 cdc7; cell division cycle 7-related protein kinase K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 733748 dbf4; protein DBF4 homolog A K06629 DBF4; protein DBF4
D 100379975 dbf4b; protein DBF4 homolog B isoform X4 K06629 DBF4; protein DBF4
C GINS complex
D 548918 gins1; DNA replication complex GINS protein PSF1 K10732 GINS1; GINS complex subunit 1
D 549769 gins2; DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 548877 gins3; DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 496455 gins4; DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 100380063 topbp1; DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 780344 recql4; ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 779545 cdc45; cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 779797 mcm8; DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 100490403 mcm9; DNA helicase MCM9 isoform X1 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 549663 mcm10; protein MCM10 homolog K10736 MCM10; minichromosome maintenance protein 10
D 100485733 helb; DNA helicase B isoform X1 K15254 HELB; DNA helicase B [EC:5.6.2.3]
D 100494750 cinp; cyclin-dependent kinase 2-interacting protein K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 779505 mtbp; mdm2-binding protein K26116 MTBP; Mdm2-binding protein
D 100489448 ticrr; treslin K26117 TICRR; Treslin
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 100379926 pola1; DNA polymerase alpha catalytic subunit isoform X2 K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 448613 pola2; DNA polymerase alpha subunit B K02321 POLA2; DNA polymerase alpha subunit B
D 407927 prim1; DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 548762 prim2; DNA primase large subunit K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 100498309 pole; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 595029 pole2; DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 550018 pole3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 549359 pole4; DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 734063 pold1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 448271 pold2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D 549310 pold3; DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
C DNA polymerase gamma complex (mitochondrial)
D 100488393 polg; DNA polymerase subunit gamma-1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 100493143 polg2; DNA polymerase subunit gamma-2, mitochondrial isoform X1 K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 548449 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
D 448500 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D 549380 rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 733476 rfc1; replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 549117 rfc4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 100216026 rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 496525 rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 100493161 rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 779807 MGC146443; uncharacterized protein LOC779807 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 100124876 rnaseh1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 100493932 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 394751 rnaseh2a; ribonuclease H2 subunit A K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 549083 rnaseh2b; ribonuclease H2 subunit B K10744 RNASEH2B; ribonuclease H2 subunit B
D 100494763 rnaseh2c; ribonuclease H2 subunit C isoform X1 K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 493302 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 100170166 dna2; DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 549759 fen1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 101734301 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 100487930 exo1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 100037867 zranb3; DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 100271763 lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 100485754 atad5; ATPase family AAA domain-containing protein 5 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 100151716 dnmt1; DNA (cytosine-5)-methyltransferase 1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 100496503 dnmt3a; DNA (cytosine-5)-methyltransferase 3A isoform X4 K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
D 100492187 DNA (cytosine-5)-methyltransferase 3A K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
C Prevention of re-replication factors
D 496859 gmnn; geminin K10749 GMNN; geminin
D 100496713 mcidas; multicilin isoform X1 K26119 MCIDAS; multicilin
D 394726 ccnb1.2; cyclin B1 K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 100101736 ccnb1; G2/mitotic-specific cyclin-B1 K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 100270772 ccnb2; cyclin B2 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 394448 cyclin B5 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 100494711 ccnb3; G2/mitotic-specific cyclin-B3 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 394503 cdk1; cyclin-dependent kinase 1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 407850 pot1; protection of telomeres protein 1 K11109 POT1; protection of telomeres protein 1
E 677737 terf1; telomeric repeat-binding factor 1 K11110 TERF1; telomeric repeat-binding factor 1
E 100233217 terf2; telomeric repeat-binding factor 2 K11111 TERF2; telomeric repeat-binding factor 2
E 100233216 tinf2; TERF1-interacting nuclear factor 2 K11112 TINF2; TERF1-interacting nuclear factor 2
E 779476 terf2ip; telomeric repeat-binding factor 2-interacting protein 1 K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
E 100145507 uncharacterized protein LOC100145507 K11114 ACD; adrenocortical dysplasia protein
D TERB1-TERB2-MAJIN complex
E 100488611 terb1; telomere repeats-binding bouquet formation protein 1 K25749 TERB1; telomere repeats-binding bouquet formation protein 1
E 101733955 terb2; telomere repeats-binding bouquet formation protein 2 isoform X1 K25750 TERB2; telomere repeats-binding bouquet formation protein 2
E 100488112 majin; membrane-anchored junction protein isoform X1 K25751 MAJIN; membrane-anchored junction protein
D CST complex (animals)
E 100158579 ctc1; CST complex subunit CTC1 K23311 CTC1; CST complex subunit CTC1
E 448268 stn1; CST complex subunit STN1 K23312 STN1; CST complex subunit STN1
E 100379818 ten1; CST complex subunit TEN1 K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 100380118 smg6; telomerase-binding protein EST1A K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 780078 smg5; protein SMG5 K11125 SMG5; protein SMG5
D 101731917 tert; telomerase reverse transcriptase isoform X1 K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D 100485265 tep1; telomerase protein component 1 K11127 TEP1; telomerase protein component 1
D Dyskerin complex
E 496698 gar1; H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 394586 nhp2; H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 548917 nop10; H/ACA ribonucleoprotein complex subunit 3 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 100145077 dkc1; H/ACA ribonucleoprotein complex subunit DKC1 isoform X1 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 101731917 tert; telomerase reverse transcriptase isoform X1 K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 407857 snrpb; small nuclear ribonucleoprotein-associated proteins B and B' K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 447999 snrpd1; small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 448710 snrpd2; small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 549847 snrpd3; small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 448738 snrpe; small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 448659 snrpf; small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 100125174 snrpg; small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 549117 rfc4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 100216026 rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 496525 rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 100493161 rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 100135381 mre11; double-strand break repair protein MRE11A K10865 MRE11; double-strand break repair protein MRE11
D 779556 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 733826 nbn; nibrin isoform X2 K10867 NBN; nibrin
C Other termination factors
D 100490767 atm; serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 734043 wrn; Werner syndrome ATP-dependent helicase isoform X1 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 100124311 blm; Bloom syndrome protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 100488663 prkdc; DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 100145552 ercc4; DNA repair endonuclease XPF isoform X1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 100490557 parp1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 100145803 parp3; poly [ADP-ribose] polymerase 3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 100495846 parp2; poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 100491674 parp4; protein mono-ADP-ribosyltransferase PARP4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 100170623 protein mono-ADP-ribosyltransferase PARP4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 779481 parp4.1; protein mono-ADP-ribosyltransferase PARP4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 101733406 protein mono-ADP-ribosyltransferase PARP4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 549762 tnks2; tankyrase-2 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 100497226 tnks; poly [ADP-ribose] polymerase tankyrase-1 isoform X2 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 448337 pinx1; PIN2/TERF1-interacting telomerase inhibitor 1 K11135 PINX1; Pin2-interacting protein X1
D 100487920 rtel1; regulator of telomere elongation helicase 1 isoform X1 K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 780338 telo2; telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 100145043 trir; uncharacterized protein C19orf43 homolog K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 100491835 rif1; telomere-associated protein RIF1 isoform X1 K11138 RIF1; telomere-associated protein RIF1
D 549357 pif1; PIF1 5'-to-3' DNA helicase K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 100135162 pura; transcriptional activator protein Pur-alpha K21772 PURA; transcriptional activator protein Pur-alpha
D 116406454 purine-rich element-binding protein gamma K21800 PURG; purine-rich element-binding protein gamma
D 100145674 sde2; replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
D 407963 rtf2; protein RTF2 homolog K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 100496521 top1.1; DNA topoisomerase 1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 779551 top1mt; DNA topoisomerase I, mitochondrial isoform X4 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 100380116 top1.2; topoisomerase (DNA) I, gene 2 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 779457 top2b; DNA topoisomerase 2-beta isoform X1 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 100038293 top2a; DNA topoisomerase 2-alpha K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 100145467 top3b; DNA topoisomerase 3-beta-1 isoform 2 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 100135734 top3a; DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 780115 ssbp1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 779807 MGC146443; uncharacterized protein LOC779807 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 100124876 rnaseh1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 100493932 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 779807 MGC146443; uncharacterized protein LOC779807 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 100124876 rnaseh1; ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
E 100493932 ribonuclease H1-like K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 100170166 dna2; DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 549759 fen1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 101734301 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 100271763 lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022