+F Repair protein KO
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DNA Repair and Recombination Proteins - Xenopus tropicalis (tropical clawed frog)
%
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 496878 mgmt; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D 100492480 alkbh2; DNA oxidative demethylase ALKBH2 K10859 ALKBH2; DNA oxidative demethylase [EC:1.14.11.33]
D 100495476 alkbh3; alpha-ketoglutarate-dependent dioxygenase alkB homolog 3 K10860 ALKBH3; mRNA N1-methyladenine demethylase [EC:1.14.11.54]
D 448036 ascc3; activating signal cointegrator 1 complex subunit 3 K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4]
C BER (base exicision repair)
D DNA glycosylases
E 549334 ung; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 407893 ccno; cyclin-O K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 100127658 uncharacterized protein LOC100127658 K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 100487999 cyclin-O protein B-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 100488065 cyclin-O protein B K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 100497655 cyclin-O protein B K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 100493210 cyclin-O protein B K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 100496868 cyclin-O protein B K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 100492352 cyclin-O protein B K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 116407063 cyclin-O protein B-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 105946680 cyclin-O protein B-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 105946681 cyclin-O protein B-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 116406526 cyclin-O protein B-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 108648358 cyclin-O protein B K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 100497033 cyclin-O protein B-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 116406532 cyclin-O protein B-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 116406533 cyclin-O protein B-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 100497169 cyclin-O protein B K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 100487861 cyclin-O protein B K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 101734092 cyclin-O protein B K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 116406534 cyclin-O protein B-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 105948066 cyclin-O protein B-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 116406535 cyclin-O protein B-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 116406536 cyclin-O protein B-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 100497341 cyclin-O protein B K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 100485581 cyclin-O protein B K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 116406781 cyclin-O protein B-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 116406431 cyclin-O protein B-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 116406785 cyclin-O protein B-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 101733918 cyclin-O protein B K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 101733971 cyclin-O protein B K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 108644459 cyclin-O protein B K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 101732324 cyclin-O protein B K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 101732872 cyclin-O protein B K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 101730848 cyclin-O protein B K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 101732116 cyclin-O protein B-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 100487024 cyclin-O protein B K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 105947858 cyclin-O protein B-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 105948062 cyclin-O protein B-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 105948063 cyclin-O protein B-like K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 105945968 cyclin-O protein B K10861 UDG2; uracil-DNA glycosylase 2 [EC:3.2.2.-]
E 448432 tdg; G/T mismatch-specific thymine DNA glycosylase K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29]
E 549932 mpg; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 100037877 smug1; single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 780292 mutyh; adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 733528 mbd4; methyl-CpG-binding domain protein 4 K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-]
E 100380072 ogg1; N-glycosylase/DNA lyase isoform X1 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E 100124806 neil1; endonuclease 8-like 1 K10567 NEIL1; endonuclease VIII-like 1 [EC:3.2.2.- 4.2.99.18]
E 100135209 neil2; endonuclease 8-like 2 K10568 NEIL2; endonuclease VIII-like 2 [EC:3.2.2.- 4.2.99.18]
E 549955 neil3; endonuclease 8-like 3 K10569 NEIL3; endonuclease VIII-like 3 [EC:3.2.2.- 4.2.99.18]
E 733472 nthl1; endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E 394929 apex1; DNA-(apurinic or apyrimidinic site) lyase K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E 448512 apex2; DNA-(apurinic or apyrimidinic site) lyase 2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F 734063 pold1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F 448271 pold2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
F 549310 pold3; DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F 100498309 pole; DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F 595029 pole2; DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F 550018 pole3; DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F 549359 pole4; DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E 493302 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 549759 fen1; flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 101734301 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 100271763 lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
E 448741 polb; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
E 100380033 xrcc1; DNA repair protein XRCC1 K10803 XRCC1; DNA-repair protein XRCC1
E 100491855 short transient receptor potential channel 2 isoform X1 K10803 XRCC1; DNA-repair protein XRCC1
E 549105 lig3; DNA ligase 3 K10776 LIG3; DNA ligase 3 [EC:6.5.1.1]
D Other BER factors
E 734106 tdp1; tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E 403092 aptx; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 100127823 aplf; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 100145800 pnkp; bifunctional polynucleotide phosphatase/kinase K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78]
E 394834 hmgb1; high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 100101731 poll; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 100490557 parp1; poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
E 100145803 parp3; poly [ADP-ribose] polymerase 3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 100495846 parp2; poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 100491674 parp4; protein mono-ADP-ribosyltransferase PARP4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 100170623 protein mono-ADP-ribosyltransferase PARP4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 779481 parp4.1; protein mono-ADP-ribosyltransferase PARP4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
E 101733406 protein mono-ADP-ribosyltransferase PARP4 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F 100145629 xpc; DNA repair protein complementing XP-C cells isoform X2 K10838 XPC; xeroderma pigmentosum group C-complementing protein
F 594966 rad23b; UV excision repair protein RAD23 homolog B K10839 RAD23; UV excision repair protein RAD23
F 549903 cetn1; centrin-2 K10840 CETN2; centrin-2
E Cul4-DDB2 complex
F 100379935 rbx1; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 548647 cul4a; cullin-4A K10609 CUL4; cullin 4
F 100151714 cul4b; cullin-4B K10609 CUL4; cullin 4
F 100485735 ddb1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 493565 ddb2; DNA damage-binding protein 2 K10140 DDB2; DNA damage-binding protein 2
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F 116409862 polr2a; DNA-directed RNA polymerase II subunit RPB1 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F 100380205 polr2b; DNA-directed RNA polymerase II subunit RPB2 isoform X1 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F 394729 polr2c; DNA-directed RNA polymerase II subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F 549002 polr2d; DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F 549227 polr2e; DNA-directed RNA polymerases I, II, and III subunit RPABC1 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F 448728 polr2f; DNA-directed RNA polymerases I, II, and III subunit RPABC2 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F 549819 polr2g; DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F 548867 polr2h; DNA-directed RNA polymerases I, II, and III subunit RPABC3 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F 100101756 polr2i; DNA-directed RNA polymerase II subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F 549097 polr2l.1; DNA-directed RNA polymerases I, II, and III subunit RPABC5 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 734135 polr2l.2; polymerase (RNA) II (DNA directed) polypeptide L, 7.6kDa, gene 2 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F 733914 polr2j; DNA-directed RNA polymerase II subunit RPB11-a K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F 549263 polr2k; DNA-directed RNA polymerases I, II, and III subunit RPABC4 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F 100379935 rbx1; E3 ubiquitin-protein ligase RBX1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F 548647 cul4a; cullin-4A K10609 CUL4; cullin 4
F 100151714 cul4b; cullin-4B K10609 CUL4; cullin 4
F 100485735 ddb1; DNA damage-binding protein 1 K10610 DDB1; DNA damage-binding protein 1
F 549933 ercc8; DNA excision repair protein ERCC-8 K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F 548810 ercc6; excision repair cross-complementation group 6 K10841 ERCC6; DNA excision repair protein ERCC-6
F 100135095 uvssa; UV-stimulated scaffold protein A K23720 UVSSA; UV-stimulated scaffold protein A
F 394607 elof1; transcription elongation factor 1 homolog K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E 100170563 ercc3; TFIIH basal transcription factor complex helicase XPB subunit K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E 493493 ercc2; TFIIH basal transcription factor complex helicase XPD subunit K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E 448768 gtf2h1; general transcription factor IIH subunit 1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E 496493 gtf2h2; general transcription factor IIH subunit 2-like protein K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E 100145792 gtf2h3; general transcription factor IIH subunit 3 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E 548562 gtf2h4; general transcription factor IIH subunit 4 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E 550052 gtf2h5; general transcription factor IIH subunit 5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E 549973 cdk7; cyclin-dependent kinase 7 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E 549010 ccnh; cyclin-H K06634 CCNH; cyclin H
E 549892 mnat1; CDK-activating kinase assembly factor MAT1 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E 548449 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 448500 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 549380 rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Other NER factors
E 549490 xpa; DNA repair protein complementing XP-A cells K10847 XPA; DNA-repair protein complementing XP-A cells
E 100135224 ercc1; DNA excision repair protein ERCC-1 K10849 ERCC1; DNA excision repair protein ERCC-1
E 100145552 ercc4; DNA repair endonuclease XPF isoform X1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E 100124735 ercc5; DNA repair protein complementing XP-G cells K10846 ERCC5; DNA excision repair protein ERCC-5
E 100271763 lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 779833 mms19; MMS19 nucleotide excision repair protein homolog K15075 MET18; DNA repair/transcription protein MET18/MMS19
E 548729 cul3; cullin-3 K03869 CUL3; cullin 3
E 780297 cul5; cullin-5 K10612 CUL5; cullin 5
E 549174 eloc; transcription elongation factor B polypeptide 1 K03872 ELOC; elongin-C
E 394559 elob; transcription elongation factor B polypeptide 2 K03873 ELOB; elongin-B
E 100144956 eloa; elongin-A K15076 ELOA; elongin-A
E 100497894 elongin-A isoform X1 K15076 ELOA; elongin-A
E 100486308 ubap2l; ubiquitin-associated protein 2-like isoform X6 K26545 UBAP2; ubiquitin-associated protein 2
E 100379870 ubap2; ubiquitin-associated protein 2 isoform X1 K26545 UBAP2; ubiquitin-associated protein 2
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E 100380043 msh2; DNA mismatch repair protein Msh2 K08735 MSH2; DNA mismatch repair protein MSH2
E 100486354 msh3; DNA mismatch repair protein Msh3 isoform X1 K08736 MSH3; DNA mismatch repair protein MSH3
E 100145639 msh6; DNA mismatch repair protein Msh6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E 548373 pms1; PMS1 protein homolog 1 K10864 PMS1; DNA mismatch repair protein PMS1
E 100170640 mlh1; DNA mismatch repair protein Mlh1 K08734 MLH1; DNA mismatch repair protein MLH1
E 100490402 pms2; mismatch repair endonuclease PMS2 K10858 PMS2; DNA mismatch repair protein PMS2
E 100493832 mlh3; DNA mismatch repair protein Mlh3 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E 734063 pold1; DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E 448271 pold2; DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
E 549310 pold3; DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E 548449 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 448500 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 549380 rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D RFC (replication factor C)
E 733476 rfc1; replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E 549117 rfc4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E 100216026 rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E 496525 rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
E 100493161 rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E 493302 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E 100487930 exo1; exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E 394834 hmgb1; high mobility group protein B1 K10802 HMGB1; high mobility group protein B1
E 100271763 lig1; DNA ligase 1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E 100379849 wdr76; WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E 100135381 mre11; double-strand break repair protein MRE11A K10865 MRE11; double-strand break repair protein MRE11
E 779556 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 733826 nbn; nibrin isoform X2 K10867 NBN; nibrin
D BRCA1-core complex
E 733513 brca1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100498289 bard1; BRCA1-associated RING domain protein 1 isoform X2 K10683 BARD1; BRCA1-associated RING domain protein 1
D BRCA1-A complex
E 733513 brca1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 733722 abraxas1; BRCA1-A complex subunit Abraxas 1 K20774 FAM175A; BRCA1-A complex subunit Abraxas
E 780212 uimc1; BRCA1-A complex subunit RAP80 K20775 UIMC1; BRCA1-A complex subunit RAP80
E 496740 babam1; BRISC and BRCA1-A complex member 1 K20776 BABAM; BRISC and BRCA1-A complex member 1
E 448242 babam2; BRISC and BRCA1-A complex member 2 K12173 BRE; BRCA1-A complex subunit BRE
E 549211 brcc3; lys-63-specific deubiquitinase BRCC36 K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D BRCA1-B complex
E 733513 brca1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100489959 brip1; Fanconi anemia group J protein isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 100380063 topbp1; DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D BRCA1-C complex
E 733513 brca1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100380142 rbbp8; DNA endonuclease RBBP8 isoform X2 K20773 RBBP8; DNA endonuclease RBBP8 [EC:3.1.-.-]
E 100135381 mre11; double-strand break repair protein MRE11A K10865 MRE11; double-strand break repair protein MRE11
E 779556 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E 733826 nbn; nibrin isoform X2 K10867 NBN; nibrin
D BRCA complex
E 733513 brca1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100038818 brca2; breast cancer type 2 susceptibility protein isoform X3 K08775 BRCA2; breast cancer 2 susceptibility protein
E 100491433 palb2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
E 549147 rad51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E 549147 rad51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 548416 rad51c; RAD51 paralog C K10870 RAD51L2; RAD51-like protein 2
E 448189 rad51d; DNA repair protein RAD51 homolog 4 K10871 RAD51L3; RAD51-like protein 3
E 100486989 xrcc2; DNA repair protein XRCC2 K10879 XRCC2; DNA-repair protein XRCC2
E 548895 xrcc3; DNA repair protein XRCC3 K10880 XRCC3; DNA-repair protein XRCC3
D Rad52 family proteins
E 100036666 rad52; DNA repair protein RAD52 homolog K10873 RAD52; DNA repair and recombination protein RAD52
E 100379988 rdm1; RAD52 motif-containing protein 1 isoform X1 K10874 RDM1; RAD52 motif-containing protein 1
D Rad54 family proteins
E 407922 rad54l; DNA repair and recombination protein RAD54-like K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E 733747 rad54l2; helicase ARIP4 K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-]
E 100158622 rad54b; DNA repair and recombination protein RAD54B K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E 549070 recql; ATP-dependent DNA helicase Q1 K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4]
E 734043 wrn; Werner syndrome ATP-dependent helicase isoform X1 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
E 100124311 blm; Bloom syndrome protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 780344 recql4; ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
E 100216093 recql5; ATP-dependent DNA helicase Q5 K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E 100124311 blm; Bloom syndrome protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 100145467 top3b; DNA topoisomerase 3-beta-1 isoform 2 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 100135734 top3a; DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 549050 rmi1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 101731578 rmi2; recQ-mediated genome instability protein 2 isoform X1 K15365 RMI2; RecQ-mediated genome instability protein 2
D RPA (replication factor A)
E 548449 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
E 448500 rpa2; replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
E 549380 rpa3; replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
D Protein phosphatase 4
E 394540 ppp4c; serine/threonine-protein phosphatase 4 catalytic subunit K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E 448623 ppp4r1; serine/threonine-protein phosphatase 4 regulatory subunit 1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 100216260 ppp4r1l; serine/threonine-protein phosphatase 4 regulatory subunit 1 isoform X1 K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1
E 496569 ppp4r2; serine/threonine-protein phosphatase 4 regulatory subunit 2 K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2
E 100485426 ppp4r3a; serine/threonine-protein phosphatase 4 regulatory subunit 3A isoform X1 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 448490 ppp4r3b; serine/threonine-protein phosphatase 4 regulatory subunit 3 K17491 SMEK; protein phosphatase 4 regulatory subunit 3
E 100487144 ppp4r4; serine/threonine-protein phosphatase 4 regulatory subunit 4 K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4
D AP-5 complex
E 100493122 ap5b1; AP-5 complex subunit beta-1 K19022 AP5B1; AP-5 complex subunit beta-1
E 100135208 ap5m1; AP-5 complex subunit mu-1 K19023 AP5M1; AP-5 complex subunit mu-1
E 100135151 ap5s1; AP-5 complex subunit sigma-1 K19024 AP5S1; AP-5 complex subunit sigma-1
E 101733879 LOW QUALITY PROTEIN: AP-5 complex subunit zeta-1 K19025 AP5Z1; AP-5 complex subunit zeta-1
D SMC5-SMC6 complex
E 100485531 smc5; structural maintenance of chromosomes protein 5 isoform X2 K22803 SMC5; structural maintenance of chromosomes protein 5
E 100495634 smc6.1; structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 100495796 smc6; structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 100496941 structural maintenance of chromosomes protein 6 K22804 SMC6; structural maintenance of chromosomes protein 6
E 780010 lratd1; protein FAM84A K22805 FAM84A; protein FAM84A
E 394610 nsmce1; non-structural maintenance of chromosomes element 1 homolog K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E 100497178 nsmce2; E3 SUMO-protein ligase NSE2 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E 549684 nsmce3; NSE3 homolog, SMC5-SMC6 complex component K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E 100495761 nsmce4a; non-structural maintenance of chromosomes element 4 homolog A K22825 NSMCE4; non-structural maintenance of chromosomes element 4
E 100495961 slf1; SMC5-SMC6 complex localization factor protein 1 isoform X2 K26126 SLF1; SMC5-SMC6 complex localization factor protein 1
E 100038045 slf2; SMC5-SMC6 complex localization factor protein 2 isoform X1 K26127 SLF2; SMC5-SMC6 complex localization factor protein 2
D Other HR factors
E 779752 eme1; crossover junction endonuclease EME1 K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E 780321 eme2; probable crossover junction endonuclease EME2 K10883 EME2; crossover junction endonuclease EME2
E 549208 exd2; exonuclease 3'-5' domain-containing protein 2 K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1]
E 496413 mus81; crossover junction endonuclease MUS81 K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E 733792 sem1; 26S proteasome complex subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E 100135158 swi5; DNA repair protein SWI5 homolog K10991 SWI5; DNA repair protein Swi5/Sae3
E 100380037 sfr1; swi5-dependent recombination DNA repair protein 1 homolog isoform X1 K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E 100127194 slx1a; structure-specific endonuclease subunit SLX1 K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E 100379741 slx4; structure-specific endonuclease subunit SLX4 K10484 BTBD12; structure-specific endonuclease subunit SLX4 (BTB/POZ domain-containing protein 12)
E 100145302 gen1; flap endonuclease GEN homolog 1 K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E 394666 spg11; spatacsin K19026 SPG11; spatacsin
E 100492179 zfyve26; zinc finger FYVE domain-containing protein 26 isoform X1 K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26
E 100380022 rad51ap1; RAD51-associated protein 1 isoform X1 K20778 RAD51AP1; RAD51-associated protein 1
E 496573 morf4l1; mortality factor 4-like protein 1 K11339 MORF4L1; mortality factor 4-like protein 1
E 100498574 samhd1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 101730829 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 116407927 deoxynucleoside triphosphate triphosphohydrolase SAMHD1-like K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-]
E 100124890 fignl1; fidgetin-like protein 1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E 100145029 spidr; DNA repair-scaffolding protein K22806 SPIDR; DNA repair-scaffolding protein
E 101733578 lratd2; protein LRATD2 K22810 FAM84B; protein FAM84B
E 100494213 brat1; BRCA1-associated ATM activator 1 K23112 BRAT1; BRCA1-associated ATM activator 1
E 394810 cfap410; cilia and flagella associated protein 410 K23456 CFAP410; cilla- and flagella-associated protein
E 394783 hdgfl2; hepatoma-derived growth factor-related protein 2 K25065 HDGFL2; hepatoma-derived growth factor-related protein 2
E 101735140 zswim7; zinc finger SWIM domain-containing protein 7 K25770 ZSWIM7; zinc finger SWIM domain-containing protein 7
E 100170436 swsap1; ATPase SWSAP1 K25771 SWSAP1; ATPase SWSAP1
E 100136947 emsy; BRCA2-interacting transcriptional repressor EMSY isoform X1 K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY
E 100495665 hsf2bp; heat shock factor 2-binding protein K25791 HSF2BP; heat shock factor 2-binding protein
E 100158637 mms22l; protein MMS22-like K26125 MMS22L; protein MMS22-like
E 100158623 tonsl; tonsoku-like protein K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2
E 100127583 bod1l1; biorientation of chromosomes in cell division protein 1-like 1 isoform X1 K27262 BOD1L1; biorientation of chromosomes in cell division protein 1-like 1
E 733805 parpbp; PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E 448213 xrcc6; X-ray repair cross-complementing protein 6 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E 100493415 xrcc5; X-ray repair cross-complementing protein 5 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
E 100488663 prkdc; DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D MRX complex
E 100135381 mre11; double-strand break repair protein MRE11A K10865 MRE11; double-strand break repair protein MRE11
E 779556 rad50; DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D DNA Ligase 4 complex
E 549735 lig4; DNA ligase 4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E 100127743 xrcc4; DNA repair protein XRCC4 K10886 XRCC4; DNA-repair protein XRCC4
E 100145147 nhej1; non-homologous end-joining factor 1 K10980 NHEJ1; non-homologous end-joining factor 1
D X-family DNA polymerases
E 100101731 poll; DNA polymerase lambda K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-]
E 548389 polm; DNA-directed DNA/RNA polymerase mu K03513 POLM; DNA polymerase mu [EC:2.7.7.7]
E 100495475 dntt; DNA nucleotidylexotransferase K00977 DNTT; DNA nucleotidylexotransferase [EC:2.7.7.31]
E 448741 polb; DNA polymerase beta K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-]
D Other NHEJ factors
E 403092 aptx; aprataxin K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E 100127823 aplf; aprataxin and PNK-like factor K13295 APLF; aprataxin and PNK-like factor [EC:3.1.-.-]
E 100493603 dclre1c; protein artemis K10887 DCLRE1C; DNA cross-link repair 1C protein [EC:3.1.-.-]
E 549698 tdp2; tyrosyl-DNA phosphodiesterase 2 K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-]
E 100380032 smchd1; structural maintenance of chromosomes flexible hinge domain-containing protein 1 K23113 SMCHD1; structural maintenance of chromosomes flexible hinge domain-containing protein 1
E 100496852 pwwp3a; PWWP domain-containing DNA repair factor 3A isoform X2 K23386 PWWP3; PWWP domain-containing DNA repair factor 3
E 100579138 paxx; protein PAXX isoform X1 K25772 PAXX; protein PAXX
E 100489485 cell cycle regulator of non-homologous end joining K26155 CYREN; cell cycle regulator of non-homologous end joining
E 100498157 jmjd8; jmjC domain-containing protein 8 K25792 JMJD8; jumonji domain-containing protein 8
E 105947450 uncharacterized protein LOC105947450 K26128 SHLD1; shieldin complex subunit 1
E 100486838 shld2; shieldin complex subunit 2 K26129 SHLD2; shieldin complex subunit 2
C FA (Fanconi anemia) pathway
D FA core complex
E 100380079 fanca; Fanconi anemia group A protein isoform X1 K10888 FANCA; fanconi anemia group A protein
E 100497907 Fanconi anemia group B protein-like K10889 FANCB; fanconi anemia group B protein
E 100496021 Fanconi anemia group B protein K10889 FANCB; fanconi anemia group B protein
E 101732237 Fanconi anemia group B protein K10889 FANCB; fanconi anemia group B protein
E 100493280 fancc; Fanconi anemia group C protein K10890 FANCC; fanconi anemia group C protein
E 100126687 fance; Fanconi anemia group E protein K10892 FANCE; fanconi anemia group E protein
E 100145108 fancf; Fanconi anemia group F protein K10893 FANCF; fanconi anemia group F protein
E 100145235 fancg; Fanconi anemia group G protein K10894 FANCG; fanconi anemia group G protein
E 493212 fancl; E3 ubiquitin-protein ligase FANCL K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27]
E 100494932 fancm; Fanconi anemia group M protein isoform X2 K10896 FANCM; fanconi anemia group M protein
E 548876 faap24; Fanconi anemia core complex-associated protein 24 K10898 FAAP24; fanconi anemia-associated protein
E 100488904 faap100; Fanconi anemia core complex-associated protein 100 isoform X1 K10993 FAAP100; fanconi anemia core complex 100 kDa subunit
D FA core complex binding factors
E 496617 hes1; transcription factor HES-1 K06054 HES1; hairy and enhancer of split 1
E 394465 hes4; transcription factor HES-4 K06054 HES1; hairy and enhancer of split 1
E 100038297 cenps; centromere protein S K11511 APITD1; centromere protein S
E 100490964 cenpx; centromere protein X isoform X1 K15360 STRA13; centromere protein X
E 101733196 ube2t; ubiquitin-conjugating enzyme E2 T isoform X2 K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23]
D Bloom's syndrome complex (BTR)
E 100124311 blm; Bloom syndrome protein K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E 100145467 top3b; DNA topoisomerase 3-beta-1 isoform 2 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 100135734 top3a; DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E 549050 rmi1; recQ-mediated genome instability protein 1 K10990 RMI1; RecQ-mediated genome instability protein 1
E 101731578 rmi2; recQ-mediated genome instability protein 2 isoform X1 K15365 RMI2; RecQ-mediated genome instability protein 2
D FANCD2-I complex
E 100487938 fancd2; Fanconi anemia group D2 protein isoform X1 K10891 FANCD2; fanconi anemia group D2 protein
E 100038061 fanci; Fanconi anemia group I protein K10895 FANCI; fanconi anemia group I protein
D Downstream FA components
E 733513 brca1; breast cancer type 1 susceptibility protein K10605 BRCA1; breast cancer type 1 susceptibility protein [EC:2.3.2.27]
E 100038818 brca2; breast cancer type 2 susceptibility protein isoform X3 K08775 BRCA2; breast cancer 2 susceptibility protein
E 100489959 brip1; Fanconi anemia group J protein isoform X1 K15362 BRIP1; fanconi anemia group J protein [EC:5.6.2.3]
E 100491433 palb2; partner and localizer of BRCA2 K10897 PALB2; partner and localizer of BRCA2
D Other FA pathway factors
E 100485224 fan1; fanconi-associated nuclease 1 isoform X1 K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1]
E 549147 rad51; DNA repair protein RAD51 homolog 1 K04482 RAD51; DNA repair protein RAD51
E 548416 rad51c; RAD51 paralog C K10870 RAD51L2; RAD51-like protein 2
E 780338 telo2; telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
E 780036 usp1; ubiquitin carboxyl-terminal hydrolase 1 K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
E 780319 wdr48; WD repeat-containing protein 48 K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
E 549864 ppp6c; serine/threonine-protein phosphatase 6 catalytic subunit K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16]
E 100491790 ppp6r1; serine/threonine-protein phosphatase 6 regulatory subunit 1 isoform X3 K15499 PPP6R1; serine/threonine-protein phosphatase 6 regulatory subunit 1
E 100125053 ppp6r2; serine/threonine-protein phosphatase 6 regulatory subunit 2 isoform X5 K15500 PPP6R2; serine/threonine-protein phosphatase 6 regulatory subunit 2
E 779971 ppp6r3; serine/threonine-protein phosphatase 6 regulatory subunit 3 K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3
E 734050 ankrd28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A isoform X3 K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A
E 100127696 ankrd52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C K15504 ANKRD52; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C
D Ubiquitin ligases
E 100216121 rnf8; E3 ubiquitin-protein ligase RNF8 K10667 RNF8; E3 ubiquitin-protein ligase RNF8 [EC:2.3.2.27]
E 100144920 rnf168; E3 ubiquitin-protein ligase rnf168 K20779 RNF168; E3 ubiquitin-protein ligase RNF168 [EC:2.3.2.31]
E 100493580 rnf169; E3 ubiquitin-protein ligase RNF169 isoform X1 K20805 RNF169; E3 ubiquitin-protein ligase RNF169 [EC:2.3.2.31]
E 100487407 herc2; E3 ubiquitin-protein ligase HERC2 isoform X1 K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26]
D Others
E 101731408 tprn; taperin isoform X1 K24164 TPRN; taperin
E 101732416 zcwpw1; zinc finger CW-type PWWP domain protein 1 isoform X2 K24688 ZCWPW1; zinc finger CW-type PWWP domain protein 1
E 780253 wdr70; WD repeat-containing protein 70 K24752 WDR70; WD repeat-containing protein 70
E 100379849 wdr76; WD repeat-containing protein 76 K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D 100487374 polh; DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D 613070 poli; DNA polymerase iota K03510 POLI; DNA polymerase iota [EC:2.7.7.7]
D 448219 polk; DNA polymerase kappa K03511 POLK; DNA polymerase kappa [EC:2.7.7.7]
D 100491842 rev1; DNA repair protein REV1 K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D 100145815 rev3l; DNA polymerase zeta catalytic subunit K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
D 101732961 poln; DNA polymerase nu K16618 POLN; DNA polymerase nu [EC:2.7.7.7]
C Rad6 epistasis group
D 448176 ube2a; ubiquitin-conjugating enzyme E2 A K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D 448706 ube2b; ubiquitin-conjugating enzyme E2 B K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
D 100494054 rad18; E3 ubiquitin-protein ligase RAD18 isoform X4 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D 394525 hltf; helicase-like transcription factor isoform X2 K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D 549030 ube2v2; ubiquitin-conjugating enzyme E2 variant 2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 100551497 ube2v1; ubiquitin-conjugating enzyme E2 variant 1 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D 395006 ube2n; ubiquitin-conjugating enzyme E2 N K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D 493302 pcna; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 733805 parpbp; PCNA-interacting partner K27412 PARPBP; PCNA-interacting partner
D 100127870 sprtn; sprT-like domain-containing protein Spartan K24051 SPRTN; SprT-like domain-contaning protein Spartan
D 100379792 gcna; acidic repeat-containing protein K26957 GCNA; germ cell nuclear acidic protein
B Check point factors
C Rad9-Hus1-Rad1 complex
D 448287 rad9a; cell cycle checkpoint control protein RAD9A K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2]
D 100490318 rad9b; cell cycle checkpoint control protein RAD9B isoform X1 K10995 RAD9B; cell cycle checkpoint control protein RAD9B
D 448560 hus1; checkpoint protein HUS1 K10903 HUS1; HUS1 checkpoint protein
D 548799 rad1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D 100379791 rad17; cell cycle checkpoint protein RAD17 K06662 HRAD17; cell cycle checkpoint protein
D 549117 rfc4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 100216026 rfc2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 496525 rfc5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 100493161 rfc3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D 548799 rad1; cell cycle checkpoint protein RAD1 K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C FPC (fork protection complex)
D 100126683 timeless; protein timeless homolog K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D 100126681 tipin; TIMELESS-interacting protein K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D 100124314 clspn; claspin isoform X1 K25773 CLSPN; claspin
C Triple T complex
D 780338 telo2; telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 100124746 tti1; TELO2-interacting protein 1 homolog K20403 TTI1; TELO2-interacting protein 1
D 100487242 tti2; TELO2-interacting protein 2 K23115 TTI2; TELO2-interacting protein 2
C BAG6-UBL4A-GET4 complex
D 100038304 bag6; large proline-rich protein bag6 isoform 1 K23390 BAG6; large proline-rich protein BAG6
D 100125140 ubl4a; ubiquitin-like protein 4A K23388 UBL4; ubiquitin-like protein 4
D 549462 get4; Golgi to ER traffic protein 4 homolog K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D 100495593 atr; serine/threonine-protein kinase ATR isoform X1 K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
D 100101245 atrip; ATR-interacting protein K10905 ATRIP; ATR interacting protein
D 100490767 atm; serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 431679 tp53; cellular tumor antigen p53 K04451 TP53; tumor protein p53
D 100038224 chek1; serine/threonine-protein kinase Chk1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D 100144952 chek2; serine/threonine-protein kinase Chk2 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D 733851 cdc25a; M-phase inducer phosphatase 1 K06645 CDC25A; M-phase inducer phosphatase 1 [EC:3.1.3.48]
D 100036608 cdc25b; M-phase inducer phosphatase 2 K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48]
D 100124300 cdc25c; M-phase inducer phosphatase 3 K05867 CDC25C; M-phase inducer phosphatase 3 [EC:3.1.3.48]
D 394780 ywhaz; 14-3-3 protein zeta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 594958 ywhaq; 14-3-3 protein theta K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 496529 ywhab; 14-3-3 protein beta/alpha K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta
D 549622 ywhah; 14-3-3 protein eta K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 779762 ywhag; 14-3-3 protein gamma K16198 YWHAG_H; 14-3-3 protein gamma/eta
D 493518 ywhae; 14-3-3 protein epsilon K06630 YWHAE; 14-3-3 protein epsilon
D 733744 nav2; neuron navigator 2 K19483 NAV2; neuron navigator 2 [EC:5.6.2.4]
D 100125126 wee2; wee1-like protein kinase 2 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 100145524 wee1; uncharacterized protein LOC100145524 K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1]
D 779488 per1; period circadian protein homolog 1 K21944 PER1; period circadian protein 1
D 100151702 per2; period circadian protein homolog 2 K02633 PER2; period circadian protein 2
D 780153 per3; period circadian protein homolog 3 K21945 PER3; period circadian protein 3
D 100489926 mdc1; mediator of DNA damage checkpoint protein 1 isoform X2 K20780 MDC1; mediator of DNA damage checkpoint protein 1
D 595091 pls3; plastin-3 K17336 PLS3; plastin-3
D 779853 aen; apoptosis-enhancing nuclease K18340 AEN; apoptosis-enhancing nuclease [EC:3.1.-.-]
D 448451 plk3; serine/threonine-protein kinase PLK3 K08862 PLK3; polo-like kinase 3 [EC:2.7.11.21]
D 100487804 plk5; inactive serine/threonine-protein kinase PLK5 K19596 PLK5; inactive serine/threonine-protein kinase PLK5
D 100036653 nek1; serine/threonine-protein kinase Nek1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 100497645 nek5; serine/threonine-protein kinase Nek5 isoform X1 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 780225 nek4; serine/threonine-protein kinase Nek4 K08857 NEK1_4_5; serine/threonine-protein kinase Nek1/4/5 [EC:2.7.11.1]
D 100489398 nek10; serine/threonine-protein kinase Nek10 isoform X1 K20879 NEK10; serine/threonine-protein kinase Nek10 [EC:2.7.11.1]
D 779890 nek11; serine/threonine-protein kinase Nek11 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 100486125 serine/threonine-protein kinase Nek11 K20880 NEK11; serine/threonine-protein kinase Nek11 [EC:2.7.11.1]
D 395018 donson; protein downstream neighbor of son homolog K22422 DONSON; protein downstream neighbor of Son
D 100170188 kank3; KN motif and ankyrin repeat domain-containing protein 3 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 100495496 kank2; KN motif and ankyrin repeat domain-containing protein 2 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 733504 kank1; KN motif and ankyrin repeat domain-containing protein 1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 779494 kank4; KN motif and ankyrin repeat domain-containing protein 4 isoform X1 K22808 KANK; KN motif and ankyrin repeat domain-containing protein
D 100495807 chmp4c; charged multivesicular body protein 4c K24782 CHMP4C; charged multivesicular body protein 4C
D 496572 vps4b; vacuolar protein sorting-associated protein 4B K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 100158600 vps4a; vacuolar protein sorting-associated protein 4A K12196 VPS4; vacuolar protein-sorting-associated protein 4
D 100144738 zfyve19; abscission/NoCut checkpoint regulator K24778 ZFYVE19; abscission/NoCut checkpoint regulator
D 100145674 sde2; replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
B Other factors with a suspected DNA repair function
C DNA polymerases
D 733897 polq; DNA polymerase theta K02349 POLQ; DNA polymerase theta [EC:2.7.7.7]
D 100135739 mybbp1a; myb-binding protein 1A K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
D 548674 primpol; DNA-directed primase/polymerase protein K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7]
C Nucleases
D 100488944 trex2; three prime repair exonuclease 2 K10791 TREX2; three prime repair exonuclease 2 [EC:3.1.11.2]
D 101733924 dclre1a; DNA cross-link repair 1A protein isoform X2 K15340 DCLRE1A; DNA cross-link repair 1A protein
D 100170639 dclre1b; 5' exonuclease Apollo K15341 DCLRE1B; DNA cross-link repair 1B protein [EC:3.1.-.-]
D 496630 endov; endonuclease V isoform X1 K21813 ENDOV; endonuclease V [EC:3.1.26.-]
D 100037867 zranb3; DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 100498215 ankle1; ankyrin repeat and LEM domain-containing protein 1 K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1
C Helicases
D 100485183 helq; helicase POLQ-like isoform X1 K19178 HELQ; POLQ-like helicase [EC:5.6.2.4]
D 100127871 ercc6l2; DNA excision repair protein ERCC-6-like 2 K20098 ERCC6L2; DNA excision repair protein ERCC-6-like 2 [EC:5.6.2.-]
C PSO4 complex
D 448017 prpf19; pre-mRNA-processing factor 19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D 493564 cdc5l; cell division cycle 5-like protein K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D 394520 bcas2; pre-mRNA-splicing factor SPF27 K12861 BCAS2; pre-mRNA-splicing factor SPF27
D 394977 plrg1; pleiotropic regulator 1 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D 100492948 nudt15; nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 448146 nudt1; 7,8-dihydro-8-oxoguanine triphosphatase K17816 NUDT1; 8-oxo-dGTP diphosphatase / 2-hydroxy-dATP diphosphatase [EC:3.6.1.55 3.6.1.56]
D 100488091 nudt18; 8-oxo-dGDP phosphatase NUDT18 K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58]
D 101733437 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D 100145720 rrm1; ribonucleoside-diphosphate reductase large subunit K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D 394645 rrm2.1; ribonucleotide reductase M2, gene 1 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 493274 rrm2.2; ribonucleoside-diphosphate reductase subunit M2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D 100144925 rrm2b; ribonucleoside-diphosphate reductase subunit M2 B K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D 496878 mgmt; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E 549334 ung; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E 100037877 smug1; single-strand selective monofunctional uracil DNA glycosylase K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-]
E 549932 mpg; DNA-3-methyladenine glycosylase K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21]
E 780292 mutyh; adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E 733472 nthl1; endonuclease III-like protein 1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E 780115 ssbp1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
D 780115 ssbp1; single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D 100492948 nudt15; nucleotide triphosphate diphosphatase NUDT15 K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D 101733437 dut; deoxyuridine 5'-triphosphate nucleotidohydrolase, mitochondrial K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024