+E Replication protein KO
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DNA Replication Proteins - Coccidioides immitis
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D CIMG_08981 origin recognition complex subunit Orc1 K02603 ORC1; origin recognition complex subunit 1
D CIMG_06189 origin recognition complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D CIMG_02248 origin recognition complex subunit 3 K02605 ORC3; origin recognition complex subunit 3
D CIMG_07975 origin recognition complex subunit Orc4 K02606 ORC4; origin recognition complex subunit 4
D CIMG_13039 CIMG06283; origin recognition complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D CIMG_09703 origin recognition complex subunit 6 K02608 ORC6; origin recognition complex subunit 6
D CIMG_07523 cell division control protein Cdc6 K02213 CDC6; cell division control protein 6
D CIMG_00047 DNA replication licensing factor MCM2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D CIMG_05014 CIMG05015; DNA replication licensing factor mcm3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D CIMG_12809 CIMG01018; cell division control protein 54 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D CIMG_06459 DNA replication licensing factor mcm5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D CIMG_00713 DNA replication licensing factor Mcm6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D CIMG_07549 DNA replication licensing factor CDC47 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
C DDK (Dbf-4 dependent kinase)
D CIMG_02088 CDC7 protein kinase K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D CIMG_01194 G1/S regulator K02309 DBF4; regulatory subunit for Cdc7p protein kinase
C GINS complex
D CIMG_07041 PSF1 domain-containing protein K10732 GINS1; GINS complex subunit 1
D CIMG_07982 DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D CIMG_01589 DNA replication complex GINS protein psf3 K10734 GINS3; GINS complex subunit 3
D CIMG_01135 GINS DNA replication complex subunit Sld5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D CIMG_12339 CIMG09370; ATP-dependent DNA helicase PIF1 K03507 DPB11; DNA replication regulator DPB11
D CIMG_08969 hypothetical protein K10731 SLD3; DNA replication regulator SLD3
D CIMG_03320 DNA replication initiation factor Cdc45 K06628 CDC45; cell division control protein 45
D CIMG_03581 DNA replication protein K10736 MCM10; minichromosome maintenance protein 10
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D CIMG_07889 DNA polymerase (pol2) K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D CIMG_09270 DNA polymerase alpha/primase associated subunit K02321 POLA2; DNA polymerase alpha subunit B
D CIMG_05534 DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D CIMG_04813 DNA primase large subunit K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D CIMG_01894 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D CIMG_04251 DNA polymerase epsilon subunit B K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D CIMG_08958 CBF/NF-Y family transcription factor K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
C DNA polymerase delta complex
D CIMG_09472 DNA polymerase (pol2) K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D CIMG_07567 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D CIMG_09453 DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
D CIMG_09701 DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
D CIMG_09312 DNA polymerase gamma K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
C RPA (replication protein A)
D CIMG_04253 replication factor-a protein 1 (rpa1) K07466 RFA1; replication factor A1
D CIMG_00224 replication factor A2 K10739 RFA2; replication factor A2
C RFC (replication factor C)
D CIMG_05232 chromosome transmission fidelity factor K10754 RFC1; replication factor C subunit 1
D CIMG_02631 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D CIMG_07623 DNA replication factor C subunit Rfc2 K10755 RFC2_4; replication factor C subunit 2/4
D CIMG_06393 activator 1 subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D CIMG_05230 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D CIMG_12678 CIMG02474; RNase H domain-containing protein K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D CIMG_02535 ribonuclease HII K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D CIMG_00759 ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D CIMG_04909 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D CIMG_13558 CIMG10249; DNA replication helicase Dna2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D CIMG_00205 DNA helicase K19783 HCS1; DNA polymerase alpha-associated DNA helicase A [EC:5.6.2.3]
D CIMG_00504 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D CIMG_05525 exonuclease K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D CIMG_00793 DNA ligase I, ATP-dependent (dnl1) K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D CIMG_09394 hypothetical protein K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D CIMG_10138 C-5 cytosine methyltransferase DmtA K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D CIMG_09340 C-5 cytosine methyltransferase DmtA K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D CIMG_01762 DNA (cytosine-5-)-methyltransferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
C Prevention of re-replication factors
C Telomere proteins
D Shelterin complex
E CIMG_07329 telomere-binding alpha subunit central domain-containing protein K11109 POT1; protection of telomeres protein 1
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
D CST complex (yeast)
D RIF proteins
D SIR proteins
E CIMG_00999 SIR2 family histone deacetylase K11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
E CIMG_01641 histone deacetylase SIR2 K11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
E CIMG_08957 SIR2 family histone deacetylase K11121 SIR2; NAD-dependent protein deacetylase SIR2 [EC:2.3.1.286]
C Telomerase complex (animals)
D Dyskerin complex
E CIMG_01792 H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E CIMG_05741 small nuclear ribonucleoprotein complex protein Nhp2 K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E CIMG_11787 H/ACA ribonucleoprotein complex subunit 3 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E CIMG_06375 centromere/microtubule-binding protein cbf5 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D Sm core complex
E CIMG_09586 small nuclear ribonucleoprotein B and B' K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E CIMG_01039 small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E CIMG_09295 small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E CIMG_09069 small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E CIMG_08166 LSM domain-containing protein K11097 SNRPE; small nuclear ribonucleoprotein E
E CIMG_00256 small nuclear ribonucleoprotein SmF K11098 SNRPF; small nuclear ribonucleoprotein F
E CIMG_04293 small nuclear ribonucleoprotein SmG K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D CIMG_02631 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D CIMG_07623 DNA replication factor C subunit Rfc2 K10755 RFC2_4; replication factor C subunit 2/4
D CIMG_06393 activator 1 subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D CIMG_05230 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D CIMG_09803 DNA repair protein (mre11) K10865 MRE11; double-strand break repair protein MRE11
D CIMG_12856 CIMG00584; rad50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
C Other termination factors
D CIMG_12324 CIMG09299; ataxia telangiectasia mutated K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D CIMG_01059 RecQ family ATP-dependent DNA helicase K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D CIMG_05777 DNA repair protein (rad1) K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D CIMG_11667 CIMG06060; polymerase K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D CIMG_07464 protein PXR1 K11135 PINX1; Pin2-interacting protein X1
D CIMG_04636 telomere length regulation protein K11137 TELO2; telomere length regulation protein
D CIMG_12338 CIMG09370; mitochondrial DNA helicase K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D CIMG_09668 hypothetical protein K23314 WRAP53; telomerase Cajal body protein 1
D CIMG_10800 CIMG01698; hypothetical protein K25059 SDE2; replication stress response regulator SDE2
D CIMG_04389 hypothetical protein K25186 RTF2; replication termination factor 2
D CIMG_09151 MYB DNA binding protein K22485 TBF1; protein TBF1
B DNA Topoisomerases
C CIMG_04822 topoisomerase I K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C CIMG_02836 DNA topoisomerase 2 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C CIMG_01798 DNA topoisomerase III K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E CIMG_12678 CIMG02474; RNase H domain-containing protein K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E CIMG_12678 CIMG02474; RNase H domain-containing protein K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E CIMG_13558 CIMG10249; DNA replication helicase Dna2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E CIMG_00504 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E CIMG_00793 DNA ligase I, ATP-dependent (dnl1) K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022