+F	Repair protein	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; DNA Repair and Recombination Proteins - Pediculus humanus corporis (human body louse)</h2>
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A<b>Eukaryotic type</b>
B  SSBR (single strand breaks repair)
C    Direct repair
D      Phum_PHUM492270 activating signal cointegrator 1 complex subunit 3, helc1, putative	K18663 ASCC3; activating signal cointegrator complex subunit 3 [EC:5.6.2.4] 
C    BER (base exicision repair)
D      DNA glycosylases
E        Phum_PHUM003120 Uracil-DNA glycosylase, putative	K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27] 
E        Phum_PHUM302160 G/t mismatch-specific thymine DNA glycosylase, putative	K20813 TDG; thymine-DNA glycosylase [EC:3.2.2.29] 
E        Phum_PHUM423010 DNA-3-methyladenine glycosylase, putative	K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21] 
E        Phum_PHUM450440 Single-strand selective monofunctional uracil DNA glycosylase, putative	K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-] 
E        Phum_PHUM171830 hypothetical protein	K10801 MBD4; methyl-CpG-binding domain protein 4 [EC:3.2.2.-] 
E        Phum_PHUM491230 8-oxoguanine DNA glycosylase, putative	K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18] 
E        Phum_PHUM423000 endonuclease III, putative	K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] 
D      AP endonucleases
E        Phum_PHUM026780 Recombination repair protein, putative	K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2] 
D      Long Patch-BER factors
E        DNA polymerase delta complex
F          Phum_PHUM453000 DNA polymerase delta catalytic subunit, putative	K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7] 
F          Phum_PHUM566820 DNA polymerase delta small subunit, putative	K02328 POLD2; DNA polymerase delta subunit 2 
F          Phum_PHUM528650 DNA polymerase subunit delta, putative	K03504 POLD3; DNA polymerase delta subunit 3 
E        DNA polymerase epsilon complex
F          Phum_PHUM420020 DNA polymerase epsilon, catalytic subunit A, putative	K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7] 
F          Phum_PHUM361790 DNA polymerase epsilon subunit, putative	K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7] 
F          Phum_PHUM474950 DNA polymerase epsilon subunit, putative	K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7] 
F          Phum_PHUM117310 DNA polymerase epsilon subunit, putative	K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7] 
E        Phum_PHUM372290 Proliferating cell nuclear antigen, putative	K04802 PCNA; proliferating cell nuclear antigen 
E        Phum_PHUM354370 Flap endonuclease 1-B, putative	K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-] 
D      Short Patch-BER factors
E        Phum_PHUM131800 DNA polymerase beta, putative	K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-] 
E        Phum_PHUM252910 DNA-repair protein XRCC1, putative	K10803 XRCC1; DNA-repair protein XRCC1 
E        Phum_PHUM186980 DNA ligase, putative	K10776 LIG3; DNA ligase 3 [EC:6.5.1.1] 
D      Other BER factors
E        Phum_PHUM097920 tyrosyl-DNA phosphodiesterase, putative	K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-] 
E        Phum_PHUM320100 aprataxin, putative	K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72] 
E        Phum_PHUM159210 polynucleotide kinase- 3'-phosphatase, putative	K08073 PNKP; bifunctional polynucleotide phosphatase/kinase [EC:3.1.3.32 2.7.1.78] 
E        Phum_PHUM006290 High mobility group protein B2, putative	K10802 HMGB1; high mobility group protein B1 
E        Phum_PHUM359150 DNA polymerase beta, putative	K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-] 
E        Phum_PHUM498090 polyA polymerase, putative	K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30] 
C    NER (nucleotide excision repair)
D      GGR (global genome repair) factors
E        XPC-HR23B-CETN2 complex
F          Phum_PHUM467580 DNA repair protein xp-C / rad4, putative	K10838 XPC; xeroderma pigmentosum group C-complementing protein 
F          Phum_PHUM577750 uv excision repair protein rad23, putative	K10839 RAD23; UV excision repair protein RAD23 
E        Cul4-DDB2 complex
F          Phum_PHUM087130 RING-box protein 1A, putative	K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32] 
F          Phum_PHUM613890 Cullin-4A, putative	K10609 CUL4; cullin 4 
F          Phum_PHUM237350 DNA damage-binding protein, putative	K10610 DDB1; DNA damage-binding protein 1 
F          Phum_PHUM473480 DNA damage-binding protein, putative	K10140 DDB2; DNA damage-binding protein 2 
E        NER4 complex
D      TCR (transcription coupled repair) factors
E        DNA-directed RNA polymerase II complex
F          Phum_PHUM268230 hypothetical protein	K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6] 
F          Phum_PHUM204950 DNA-directed RNA polymerase II 135 kDa polypeptide, putative	K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6] 
F          Phum_PHUM249080 DNA-directed RNA polymerase II 33 kDa polypeptide, putative	K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3 
F          Phum_PHUM414840 DNA-directed RNA polymerase II 23 kDa polypeptide, putative	K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1 
F          Phum_PHUM150050 DNA-directed RNA polymerases I, II, and III 14.4 kDa polypeptide, putative	K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2 
F          Phum_PHUM180020 DNA-directed RNA polymerases I, II, and III 17.1 kDa polypeptide, putative	K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3 
F          Phum_PHUM569720 DNA-directed RNA polymerase II 15.1 kDa polypeptide, putative	K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9 
F          Phum_PHUM011520 DNA-directed RNA polymerase II subunit J, putative	K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11 
F          Phum_PHUM290480 DNA-directed RNA polymerases I, II, and III 7.0 kDa polypeptide, putative	K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4 
E        Cul4-CSA complex
F          Phum_PHUM087130 RING-box protein 1A, putative	K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32] 
F          Phum_PHUM613890 Cullin-4A, putative	K10609 CUL4; cullin 4 
F          Phum_PHUM237350 DNA damage-binding protein, putative	K10610 DDB1; DNA damage-binding protein 1 
F          Phum_PHUM419860 DNA excision repair protein ERCC-8, putative	K10570 ERCC8; DNA excision repair protein ERCC-8 
E        Other TCR factor
F          Phum_PHUM233530 DNA repair and recombination protein RAD26, putative	K10841 ERCC6; DNA excision repair protein ERCC-6 
F          Phum_PHUM027860 DNA double-strand break repair Rad50 ATPase, putative	K23720 UVSSA; UV-stimulated scaffold protein A 
F          Phum_PHUM267710 hypothetical protein	K25829 ELOF1; transcription elongation factor 1 
D      TFIIH complex
E        Phum_PHUM087570 DNA excision repair protein haywire, putative	K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4] 
E        Phum_PHUM583990 TFIIH basal transcription factor complex helicase subunit, putative	K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3] 
E        Phum_PHUM086680 TFIIH basal transcription factor complex subunit, putative	K03141 TFIIH1; transcription initiation factor TFIIH subunit 1 
E        Phum_PHUM169850 TFIIH basal transcription factor complex p44 subunit, putative	K03142 TFIIH2; transcription initiation factor TFIIH subunit 2 
E        Phum_PHUM518520 TFIIH basal transcription factor complex p52 subunit, putative	K03144 TFIIH4; transcription initiation factor TFIIH subunit 4 
E        Phum_PHUM268950 TFIIH basal transcription factor complex TTD-A subunit, putative	K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit 
E        Phum_PHUM399490 mitogen-activated protein kinase ERK-A, putative	K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23] 
E        Phum_PHUM009100 cyclin H, putative	K06634 CCNH; cyclin H 
E        Phum_PHUM037380 CDK-activating kinase assembly factor MAT1, putative	K10842 MNAT1; CDK-activating kinase assembly factor MAT1 
D      RPA (replication factor A)
E        Phum_PHUM459200 Replication protein A 70 kDa DNA-binding subunit, putative	K07466 RFA1; replication factor A1 
E        Phum_PHUM249390 Replication protein A 32 kDa subunit, putative	K10739 RFA2; replication factor A2 
E        Phum_PHUM450600 Replication protein A 14 kDa subunit, putative	K10740 RPA3; replication factor A3 
D      Other NER factors
E        Phum_PHUM505840 DNA-repair protein, putative	K10847 XPA; DNA-repair protein complementing XP-A cells 
E        Phum_PHUM004550 DNA excision repair protein ERCC-1, putative	K10849 ERCC1; DNA excision repair protein ERCC-1 
E        Phum_PHUM489110 protein mei-9, putative	K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-] 
E        Phum_PHUM462880 DNA excision repair protein, putative	K10846 ERCC5; DNA excision repair protein ERCC-5 
E        Phum_PHUM238560 DNA repair/transcription protein met18/mms19, putative	K15075 MET18; DNA repair/transcription protein MET18/MMS19 
E        Phum_PHUM587350 Cullin-3, putative	K03869 CUL3; cullin 3 
E        Phum_PHUM106430 Cullin-5, putative	K10612 CUL5; cullin 5 
E        Phum_PHUM253690 transcription elongation factor B polypeptide, putative	K03872 ELOC; elongin-C 
E        Phum_PHUM529480 transcription elongation factor B polypeptide, putative	K03873 ELOB; elongin-B 
E        Phum_PHUM128980 transcription elongation factor B polypeptide, putative	K15076 ELOA; elongin-A 
E        Phum_PHUM210120 lingerer, putative	K26545 UBAP2; ubiquitin-associated protein 2 
C    MMR (mismatch excision repair)
D      Mismatch and loop recognition factors
E        Phum_PHUM253730 DNA mismatch repair protein MsH2, putative	K08735 MSH2; DNA mismatch repair protein MSH2 
E        Phum_PHUM253520 hypothetical protein	K08737 MSH6; DNA mismatch repair protein MSH6 
D      MutL homologs
E        Phum_PHUM359740 DNA mismatch repair protein pms1, putative	K10864 PMS1; DNA mismatch repair protein PMS1 
E        Phum_PHUM178580 DNA mismatch repair protein MlH1, putative	K08734 MLH1; DNA mismatch repair protein MLH1 
E        Phum_PHUM182300 DNA mismatch repair protein pms2, putative	K10858 PMS2; DNA mismatch repair protein PMS2 
E        Phum_PHUM547400 DNA mismatch repair protein, putative	K08739 MLH3; DNA mismatch repair protein MLH3 
D      DNA polymerase delta complex
E        Phum_PHUM453000 DNA polymerase delta catalytic subunit, putative	K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7] 
E        Phum_PHUM566820 DNA polymerase delta small subunit, putative	K02328 POLD2; DNA polymerase delta subunit 2 
E        Phum_PHUM528650 DNA polymerase subunit delta, putative	K03504 POLD3; DNA polymerase delta subunit 3 
D      RPA (replication factor A)
E        Phum_PHUM459200 Replication protein A 70 kDa DNA-binding subunit, putative	K07466 RFA1; replication factor A1 
E        Phum_PHUM249390 Replication protein A 32 kDa subunit, putative	K10739 RFA2; replication factor A2 
E        Phum_PHUM450600 Replication protein A 14 kDa subunit, putative	K10740 RPA3; replication factor A3 
D      RFC (replication factor C)
E        Phum_PHUM268450 Replication factor C subunit, putative	K10754 RFC1; replication factor C subunit 1 
E        Phum_PHUM591570 Replication factor C subunit, putative	K10755 RFC2_4; replication factor C subunit 2/4 
E        Phum_PHUM237330 Replication factor C subunit, putative	K10755 RFC2_4; replication factor C subunit 2/4 
E        Phum_PHUM253510 Replication factor C subunit, putative	K10756 RFC3_5; replication factor C subunit 3/5 
E        Phum_PHUM473490 Replication factor C subunit, putative	K10756 RFC3_5; replication factor C subunit 3/5 
D      Other MMR factors
E        Phum_PHUM372290 Proliferating cell nuclear antigen, putative	K04802 PCNA; proliferating cell nuclear antigen 
E        Phum_PHUM400460 exonuclease, putative	K10746 EXO1; exonuclease 1 [EC:3.1.-.-] 
E        Phum_PHUM006290 High mobility group protein B2, putative	K10802 HMGB1; high mobility group protein B1 
B  DSBR (double strand breaks repair)
C    HR (homologous recombination)
D      MRN(MRX) complex
E        Phum_PHUM168400 Double-strand break repair protein MRE11A, putative	K10865 MRE11; double-strand break repair protein MRE11 
E        Phum_PHUM549380 DNA repair protein RAD50, putative	K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-] 
E        Phum_PHUM095740 hypothetical protein	K10867 NBN; nibrin 
D      BRCA1-core complex
E        Phum_PHUM253180 BRCA1-associated RING domain protein, putative	K10683 BARD1; BRCA1-associated RING domain protein 1 
D      BRCA1-A complex
E        Phum_PHUM249620 COP9 signalosome complex subunit 5A, putative	K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-] 
D      BRCA1-B complex
E        Phum_PHUM500580 hypothetical protein	K10728 TOPBP1; topoisomerase (DNA) II binding protein 1 
D      BRCA1-C complex
E        Phum_PHUM168400 Double-strand break repair protein MRE11A, putative	K10865 MRE11; double-strand break repair protein MRE11 
E        Phum_PHUM549380 DNA repair protein RAD50, putative	K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-] 
E        Phum_PHUM095740 hypothetical protein	K10867 NBN; nibrin 
D      BRCA complex
E        Phum_PHUM580760 breast cancer type 2 susceptibility protein brca2, putative	K08775 BRCA2; breast cancer 2 susceptibility protein 
E        Phum_PHUM458200 DNA repair protein rad51, putative	K04482 RAD51; DNA repair protein RAD51 
D      RecA family proteins
E        Phum_PHUM458200 DNA repair protein rad51, putative	K04482 RAD51; DNA repair protein RAD51 
E        Phum_PHUM253530 hypothetical protein	K10870 RAD51L2; RAD51-like protein 2 
E        Phum_PHUM238900 hypothetical protein	K10871 RAD51L3; RAD51-like protein 3 
D      Rad52 family proteins
D      Rad54 family proteins
E        Phum_PHUM513160 hypothetical protein	K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-] 
E        Phum_PHUM576960 steroid receptor-interacting snf2 domain protein, putative	K10876 RAD54L2; RAD54-like protein 2 [EC:5.6.2.-] 
E        Phum_PHUM565420 DNA repair and recombination protein RAD54B, putative	K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-] 
D      RecQ family DNA helicases
E        Phum_PHUM537310 ATP-dependent DNA helicase Q1, putative	K10899 RECQL; ATP-dependent DNA helicase Q1 [EC:5.6.2.4] 
E        Phum_PHUM308920 blooms syndrome DNA helicase, putative	K10901 BLM; bloom syndrome protein [EC:5.6.2.4] 
E        Phum_PHUM580900 ATP-dependent DNA helicase Q4, putative	K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4] 
E        Phum_PHUM178540 DNA helicase recq5, putative	K10902 RECQL5; ATP-dependent DNA helicase Q5 [EC:5.6.2.4] 
D      Bloom's syndrome complex (BTR)
E        Phum_PHUM308920 blooms syndrome DNA helicase, putative	K10901 BLM; bloom syndrome protein [EC:5.6.2.4] 
E        Phum_PHUM362520 DNA topoisomerase 3-alpha, putative	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
E        Phum_PHUM122530 DNA topoisomerase 3-beta, putative	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
E        Phum_PHUM164070 hypothetical protein	K10990 RMI1; RecQ-mediated genome instability protein 1 
D      RPA (replication factor A)
E        Phum_PHUM459200 Replication protein A 70 kDa DNA-binding subunit, putative	K07466 RFA1; replication factor A1 
E        Phum_PHUM249390 Replication protein A 32 kDa subunit, putative	K10739 RFA2; replication factor A2 
E        Phum_PHUM450600 Replication protein A 14 kDa subunit, putative	K10740 RPA3; replication factor A3 
D      Protein phosphatase 4
E        Phum_PHUM448770 serine/threonine-protein phosphatase PP-V, putative	K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16] 
E        Phum_PHUM581580 serine/threonine protein phosphatase 2A regulatory subunit A, putative	K15424 PPP4R1; serine/threonine-protein phosphatase 4 regulatory subunit 1 
E        Phum_PHUM392300 hypothetical protein	K15425 PPP4R2; serine/threonine-protein phosphatase 4 regulatory subunit 2 
E        Phum_PHUM546570 hypothetical protein	K17491 SMEK; protein phosphatase 4 regulatory subunit 3 
E        Phum_PHUM596010 hypothetical protein	K15426 PPP4R4; serine/threonine-protein phosphatase 4 regulatory subunit 4 
D      AP-5 complex
D      SMC5-SMC6 complex
E        Phum_PHUM236530 DNA double-strand break repair Rad50 ATPase, putative	K22803 SMC5; structural maintenance of chromosomes protein 5 
E        Phum_PHUM609400 structural maintenance of chromosome, putative	K22804 SMC6; structural maintenance of chromosomes protein 6 
E        Phum_PHUM450850 Non-structural maintenance of chromosome element, putative	K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27] 
E        Phum_PHUM126170 Melanoma-associated antigen G1, putative	K22823 NSMCE3; non-structural maintenance of chromosomes element 3 
E        Phum_PHUM091750 protein C10orf86, putative	K22825 NSMCE4; non-structural maintenance of chromosomes element 4 
D      Other HR factors
E        Phum_PHUM359190 Crossover junction endonuclease EME1, putative	K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-] 
E        Phum_PHUM002160 3-5 exonuclease, putative	K20777 EXD2; exonuclease 3'-5' domain-containing protein 2 [EC:3.1.11.1] 
E        Phum_PHUM357610 hypothetical protein	K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-] 
E        Phum_PHUM609030 hypothetical protein	K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-] 
E        Phum_PHUM380540 hypothetical protein	K19026 SPG11; spatacsin 
E        Phum_PHUM418720 zinc finger protein FYVE domain containing protein, putative	K19027 ZFYVE26; zinc finger FYVE domain-containing protein 26 
E        Phum_PHUM400130 hypothetical protein	K11339 MORF4L1; mortality factor 4-like protein 1 
E        Phum_PHUM292540 SAM domain and HD domain-containing protein, putative	K22544 SAMHD1; deoxynucleoside triphosphate triphosphohydrolase SAMHD1 [EC:3.1.5.-] 
E        Phum_PHUM423210 Katanin p60 ATPase-containing subunit A1, putative	K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-] 
E        Phum_PHUM328430 Katanin p60 ATPase-containing subunit, putative	K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-] 
E        Phum_PHUM429670 hypothetical protein	K23112 BRAT1; BRCA1-associated ATM activator 1 
E        Phum_PHUM208250 leucine rich repeat protein, putative	K23456 CFAP410; cilla- and flagella-associated protein 
E        Phum_PHUM463230 protein EMSY, putative	K25790 EMSY; BRCA2-interacting transcriptional repressor EMSY 
E        Phum_PHUM434930 Heat shock factor 2-binding protein, putative	K25791 HSF2BP; heat shock factor 2-binding protein 
E        Phum_PHUM418060 tpr and ank domain-containing protein, putative	K09257 NFKBIL2; NF-kappa-B inhibitor-like protein 2 
C    NHEJ (non-homologous end-joining)
D      DNA-PK complex
E        Phum_PHUM543830 ATP-dependent DNA helicase 2 subunit, putative	K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1 
E        Phum_PHUM529370 ku P80 DNA helicase, putative	K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2 
D      MRX complex
E        Phum_PHUM168400 Double-strand break repair protein MRE11A, putative	K10865 MRE11; double-strand break repair protein MRE11 
E        Phum_PHUM549380 DNA repair protein RAD50, putative	K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-] 
D      DNA Ligase 4 complex
E        Phum_PHUM592850 DNA ligase, putative	K10777 LIG4; DNA ligase 4 [EC:6.5.1.1] 
E        Phum_PHUM219790 hypothetical protein	K10886 XRCC4; DNA-repair protein XRCC4 
D      X-family DNA polymerases
E        Phum_PHUM359150 DNA polymerase beta, putative	K03512 POLL; DNA polymerase lambda [EC:2.7.7.7 4.2.99.-] 
E        Phum_PHUM131800 DNA polymerase beta, putative	K02330 POLB; DNA polymerase beta [EC:2.7.7.7 4.2.99.-] 
D      Other NHEJ factors
E        Phum_PHUM320100 aprataxin, putative	K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72] 
E        Phum_PHUM150080 TRAF and TNF receptor-associated protein, putative	K19619 TDP2; tyrosyl-DNA phosphodiesterase 2 [EC:3.1.4.-] 
C    FA (Fanconi anemia) pathway
D      FA core complex
E        Phum_PHUM117540 ubiquitin ligase protein FANCL, putative	K10606 FANCL; E3 ubiquitin-protein ligase FANCL [EC:2.3.2.27] 
D      FA core complex binding factors
E        Phum_PHUM043390 ubiquitin-conjugating enzyme E2 T, putative	K13960 UBE2T; ubiquitin-conjugating enzyme E2 T [EC:2.3.2.23] 
D      Bloom's syndrome complex (BTR)
E        Phum_PHUM308920 blooms syndrome DNA helicase, putative	K10901 BLM; bloom syndrome protein [EC:5.6.2.4] 
E        Phum_PHUM362520 DNA topoisomerase 3-alpha, putative	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
E        Phum_PHUM122530 DNA topoisomerase 3-beta, putative	K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1] 
E        Phum_PHUM164070 hypothetical protein	K10990 RMI1; RecQ-mediated genome instability protein 1 
D      FANCD2-I complex
E        Phum_PHUM317660 hypothetical protein	K10895 FANCI; fanconi anemia group I protein 
D      Downstream FA components
E        Phum_PHUM580760 breast cancer type 2 susceptibility protein brca2, putative	K08775 BRCA2; breast cancer 2 susceptibility protein 
D      Other FA pathway factors
E        Phum_PHUM140880 hypothetical protein	K15363 FAN1; fanconi-associated nuclease 1 [EC:3.1.21.- 3.1.4.1] 
E        Phum_PHUM458200 DNA repair protein rad51, putative	K04482 RAD51; DNA repair protein RAD51 
E        Phum_PHUM253530 hypothetical protein	K10870 RAD51L2; RAD51-like protein 2 
E        Phum_PHUM411860 ubiquitin specific protease, putative	K11832 USP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12] 
E        Phum_PHUM473010 WD-repeat protein, putative	K15361 WDR48; WD repeat-containing protein 48 
C    Other DSBR factors
D      Protein phosphatase 6
E        Phum_PHUM290490 serine/threonine-protein phosphatase PP-V, putative	K15498 PPP6C; serine/threonine-protein phosphatase 6 catalytic subunit [EC:3.1.3.16] 
E        Phum_PHUM537070 hypothetical protein	K15501 PPP6R3; serine/threonine-protein phosphatase 6 regulatory subunit 3 
E        Phum_PHUM299240 ankyrin repeat domain-containing protein, putative	K15502 ANKRD28; serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A 
D      Ubiquitin ligases
E        Phum_PHUM338390 hect E3 ubiquitin ligase, putative	K10595 HERC2; E3 ubiquitin-protein ligase HERC2 [EC:2.3.2.26] 
D      Others
E        Phum_PHUM489250 WD-repeat protein, putative	K23314 WRAP53; telomerase Cajal body protein 1 
E        Phum_PHUM516260 hypothetical protein	K24752 WDR70; WD repeat-containing protein 70 
B  TLS (translesion DNA synthesis) factors
C    Y-family DNA polymerases
D      Phum_PHUM333130 terminal deoxycytidyl transferase rev1, putative	K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-] 
C    B-family DNA polymerases
D      Phum_PHUM106820 DNA polymerase zeta catalytic subunit, putative	K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7] 
C    A-family DNA polymerase
C    Rad6 epistasis group
D      Phum_PHUM599030 ubiquitin-conjugating enzyme E2-17 kDa, putative	K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23] 
D      Phum_PHUM281670 ubiquitin-conjugating enzyme E2 variant, putative	K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant 
D      Phum_PHUM593530 ubiquitin-conjugating enzyme E2-17 kDa, putative	K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23] 
C    Other TLS factors
D      Phum_PHUM372290 Proliferating cell nuclear antigen, putative	K04802 PCNA; proliferating cell nuclear antigen 
D      Phum_PHUM392330 hypothetical protein	K24051 SPRTN; SprT-like domain-contaning protein Spartan 
D      Phum_PHUM458260 hypothetical protein	K26957 GCNA; germ cell nuclear acidic protein 
B  Check point factors
C    Rad9-Hus1-Rad1 complex
D      Phum_PHUM317200 DNA repair protein rad9, putative	K10994 RAD9A; cell cycle checkpoint control protein RAD9A [EC:3.1.11.2] 
D      Phum_PHUM466030 Checkpoint protein HUS1, putative	K10903 HUS1; HUS1 checkpoint protein 
D      Phum_PHUM246580 Cell cycle checkpoint protein RAD1, putative	K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2] 
C    HRAD17(Rad24)-RFC complex
D      Phum_PHUM491210 cell cycle checkpoint protein rad17, putative	K06662 HRAD17; cell cycle checkpoint protein 
D      Phum_PHUM591570 Replication factor C subunit, putative	K10755 RFC2_4; replication factor C subunit 2/4 
D      Phum_PHUM237330 Replication factor C subunit, putative	K10755 RFC2_4; replication factor C subunit 2/4 
D      Phum_PHUM253510 Replication factor C subunit, putative	K10756 RFC3_5; replication factor C subunit 3/5 
D      Phum_PHUM473490 Replication factor C subunit, putative	K10756 RFC3_5; replication factor C subunit 3/5 
C    Rad17-Mec3-Ddc1 complex
D      Phum_PHUM246580 Cell cycle checkpoint protein RAD1, putative	K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2] 
C    FPC (fork protection complex)
D      Phum_PHUM228150 timeless, putative	K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1 
D      Phum_PHUM506330 hypothetical protein	K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3 
D      Phum_PHUM420300 Claspin, putative	K25773 CLSPN; claspin 
C    Triple T complex
D      Phum_PHUM376830 hypothetical protein	K20403 TTI1; TELO2-interacting protein 1 
C    BAG6-UBL4A-GET4 complex
D      Phum_PHUM537450 hypothetical protein	K23390 BAG6; large proline-rich protein BAG6 
D      Phum_PHUM041370 ubiquitin, putative	K23388 UBL4; ubiquitin-like protein 4 
D      Phum_PHUM160580 hypothetical protein	K23387 GET4; golgi to ER traffic protein 4 
C    Other check point factors
D      Phum_PHUM003170 serine/threonine-protein kinase ATR, putative	K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1] 
D      Phum_PHUM472530 ataxia telangiectasia mutated, putative	K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1] 
D      Phum_PHUM346290 cAMP-dependent protein kinase catalytic subunit, putative	K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1] 
D      Phum_PHUM016570 cAMP-dependent protein kinase catalytic subunit, putative	K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1] 
D      Phum_PHUM420140 M-phase inducer phosphatase, putative	K05866 CDC25B; M-phase inducer phosphatase 2 [EC:3.1.3.48] 
D      Phum_PHUM507100 hypothetical protein	K16197 YWHAB_Q_Z; 14-3-3 protein beta/theta/zeta 
D      Phum_PHUM316950 14-3-3 protein epsilon, putative	K06630 YWHAE; 14-3-3 protein epsilon 
D      Phum_PHUM479050 hypothetical protein	K19483 NAV2; neuron navigator 2 [EC:5.6.2.4] 
D      Phum_PHUM378600 serine/threonine-protein kinase Nek7, putative	K06632 WEE1; wee1-like protein kinase [EC:2.7.11.1] 
D      Phum_PHUM247270 period circadian protein, putative	K02633 PER2; period circadian protein 2 
D      Phum_PHUM297950 Cytoskeletal protein Sojo, putative	K20780 MDC1; mediator of DNA damage checkpoint protein 1 
D      Phum_PHUM267720 Plastin-3, putative	K17336 PLS3; plastin-3 
D      Phum_PHUM605210 hypothetical protein	K22422 DONSON; protein downstream neighbor of Son 
D      Phum_PHUM524820 ankyrin repeat-containing protein, putative	K22808 KANK; KN motif and ankyrin repeat domain-containing protein 
D      Phum_PHUM537990 vacuolar sorting protein 4A, putative	K12196 VPS4; vacuolar protein-sorting-associated protein 4 
D      Phum_PHUM399910 hypothetical protein	K24778 ZFYVE19; abscission/NoCut checkpoint regulator 
D      Phum_PHUM546560 hypothetical protein	K25059 SDE2; replication stress response regulator SDE2 
B  Other factors with a suspected DNA repair function
C    DNA polymerases
D      Phum_PHUM150880 DNA polymerase theta, putative	K02349 POLQ; DNA polymerase theta [EC:2.7.7.7] 
D      Phum_PHUM375990 DNA polymerase V, putative	K02331 POL5; DNA polymerase phi [EC:2.7.7.7] 
D      Phum_PHUM399870 hypothetical protein	K22761 PRIMPOL; DNA-directed primase/polymerase protein [EC:2.7.7.102 2.7.7.7] 
C    Nucleases
D      Phum_PHUM581960 hypothetical protein	K10790 TREX1; three prime repair exonuclease 1 [EC:3.1.11.2] 
D      Phum_PHUM388320 asparagine-rich protein, putative	K21411 ANKLE1; ankyrin repeat and LEM domain-containing protein 1 
C    Helicases
D      Phum_PHUM530580 DNA polymerase theta, putative	K19178 HELQ; POLQ-like helicase [EC:5.6.2.4] 
C    PSO4 complex
D      Phum_PHUM000240 pre-mRNA-splicing factor, putative	K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27] 
D      Phum_PHUM450840 cell division control protein, putative	K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1 
D      Phum_PHUM359200 hypothetical protein	K12861 BCAS2; pre-mRNA-splicing factor SPF27 
D      Phum_PHUM407120 Pleiotropic regulator, putative	K12862 PLRG1; pleiotropic regulator 1 
C    Modulation of nucleotide pools
D      Phum_PHUM430950 mutt/nudix hydrolase, putative	K17817 NUDT18; 8-oxo-dGDP phosphatase [EC:3.6.1.58] 
D      Phum_PHUM301390 Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative	K01520 dut; dUTP diphosphatase [EC:3.6.1.23] 
D      Phum_PHUM350970 Ribonucleoside-diphosphate reductase large chain, putative	K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1] 
D      Phum_PHUM293080 Ribonucleoside-diphosphate reductase M2 subunit, putative	K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1] 
#
A<b>Prokaryotic type</b>
B  SSBR (single strand breaks repair)
C    Direct repair
C    BER (base exicision repair)
D      DNA glycosylases
E        Phum_PHUM003120 Uracil-DNA glycosylase, putative	K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27] 
E        Phum_PHUM450440 Single-strand selective monofunctional uracil DNA glycosylase, putative	K10800 SMUG1; single-strand selective monofunctional uracil DNA glycosylase [EC:3.2.2.-] 
E        Phum_PHUM423010 DNA-3-methyladenine glycosylase, putative	K03652 MPG; DNA-3-methyladenine glycosylase [EC:3.2.2.21] 
E        Phum_PHUM423000 endonuclease III, putative	K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] 
D      AP endonucleases
D      RecJ
D      DNA ligase
D      DNA polymerase I
C    NER (nucleotide excision repair)
D      GGR (global genome repair) factors
D      TCR (transcription coupled repair) factors
E        DNA-directed RNA polymerase complex (RNAP)
E        TRCF (transcription-repair coupling factor)
C    MMR (mismatch excision repair)
D      Mismatch and loop recognition factors
D      Molecular matchmaker
D      Strand discrimination factor
D      DNA exonucleases
D      DNA polymerase III holoenzyme
D      DNA ligase
D      Other MMR factors
B  DSBR (double strand breaks repair)
C    HR (homologous recombination)
D      RecBC pathway proteins
D      RecFOR pathway proteins
D      AddAB pathway proteins
D      Other HR factor
D      Archaeal homologous recombinant proteins
C    NHEJ (non-homologous end-joining)
D      Two-component NHEJ DNA repair complex
D      SHIIR (short-homology-independent illegitimate recombination)
E        Facilitator
E        Supressor
D      SHDIR (short-homology-dependent illegitimate recombination)
E        RecET pathway
E        Facilitator
E        Supressor
B  TLS (translesion DNA synthesis) factors
C    Y-family DNA polymerases
C    Other SOS response factors
B  Other factors with a suspected DNA repair function
C    DNA polymerase
C    DNA helicases
C    Modulation of nucleotide pools
D      Phum_PHUM301390 Deoxyuridine 5'-triphosphate nucleotidohydrolase, putative	K01520 dut; dUTP diphosphatase [EC:3.6.1.23] 
C    Others
!
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#Last updated: March 29, 2024