+D GENES KO
#
KEGG Orthology (KO) - Thermodesulfobacterium geofontis
%
!
A09100 Metabolism
B
B 09101 Carbohydrate metabolism
C 00010 Glycolysis / Gluconeogenesis [PATH:top00010]
D TOPB45_0411 Glucokinase K00845 glk; glucokinase [EC:2.7.1.2]
D TOPB45_0294 phosphoglucose isomerase (PGI) K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]
D TOPB45_1305 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D TOPB45_0677 protein of unknown function DUF100 K01622 K01622; fructose 1,6-bisphosphate aldolase/phosphatase [EC:4.1.2.13 3.1.3.11]
D TOPB45_0104 triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]
D TOPB45_1384 Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D TOPB45_1386 Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D TOPB45_0105 Phosphoglycerate kinase K00927 PGK; phosphoglycerate kinase [EC:2.7.2.3]
D TOPB45_0850 phosphonopyruvate decarboxylase-related protein K15635 apgM; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]
D TOPB45_1613 proposed homoserine kinase K15635 apgM; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]
D TOPB45_0128 Enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
D TOPB45_1042 pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40]
D TOPB45_1385 Pyruvate, phosphate dikinase K01006 ppdK; pyruvate, orthophosphate dikinase [EC:2.7.9.1]
D TOPB45_0109 phosphoenolpyruvate synthase K01007 pps; pyruvate, water dikinase [EC:2.7.9.2]
D TOPB45_1600 Pyruvate synthase K00169 porA; pyruvate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.1]
D TOPB45_1601 Pyruvate synthase K00170 porB; pyruvate ferredoxin oxidoreductase beta subunit [EC:1.2.7.1]
D TOPB45_1598 pyruvate/ketoisovalerate oxidoreductase, gamma subunit K00172 porC; pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.1]
D TOPB45_1599 pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit K00171 porD; pyruvate ferredoxin oxidoreductase delta subunit [EC:1.2.7.1]
D TOPB45_0672 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) K00174 korA; 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11]
D TOPB45_0671 2-oxoglutarate synthase K00175 korB; 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11]
D TOPB45_0244 Alcohol dehydrogenase (NADP(+)) K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
D TOPB45_0636 Acetate--CoA ligase K01895 ACSS1_2; acetyl-CoA synthetase [EC:6.2.1.1]
D TOPB45_0633 acetyl coenzyme A synthetase (ADP forming), alpha domain protein K24012 acdAB; acetate---CoA ligase (ADP-forming) [EC:6.2.1.13]
D TOPB45_0214 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III K15778 pmm-pgm; phosphomannomutase / phosphoglucomutase [EC:5.4.2.8 5.4.2.2]
D TOPB45_0887 Aldehyde ferredoxin oxidoreductase K11389 gapor; glyceraldehyde-3-phosphate dehydrogenase (ferredoxin) [EC:1.2.7.6]
C 00020 Citrate cycle (TCA cycle) [PATH:top00020]
D TOPB45_1562 putative cache sensor protein K05942 E2.3.3.3; citrate (Re)-synthase [EC:2.3.3.3]
D TOPB45_1586 aconitate hydratase K01681 ACO; aconitate hydratase [EC:4.2.1.3]
D TOPB45_1434 isocitrate dehydrogenase, NADP-dependent K00031 IDH1; isocitrate dehydrogenase [EC:1.1.1.42]
D TOPB45_0672 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) K00174 korA; 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11]
D TOPB45_0671 2-oxoglutarate synthase K00175 korB; 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11]
D TOPB45_0670 Pyruvate/ketoisovalerate oxidoreductase K00177 korC; 2-oxoglutarate ferredoxin oxidoreductase subunit gamma [EC:1.2.7.3]
D TOPB45_0673 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein K00176 korD; 2-oxoglutarate ferredoxin oxidoreductase subunit delta [EC:1.2.7.3]
D TOPB45_0234 hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit K01677 E4.2.1.2AA; fumarate hydratase subunit alpha [EC:4.2.1.2]
D TOPB45_1624 hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit K01678 E4.2.1.2AB; fumarate hydratase subunit beta [EC:4.2.1.2]
D TOPB45_0217 Malate dehydrogenase K00024 mdh; malate dehydrogenase [EC:1.1.1.37]
D TOPB45_0713 Pyruvate carboxylase K01958 PC; pyruvate carboxylase [EC:6.4.1.1]
D TOPB45_1600 Pyruvate synthase K00169 porA; pyruvate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.1]
D TOPB45_1601 Pyruvate synthase K00170 porB; pyruvate ferredoxin oxidoreductase beta subunit [EC:1.2.7.1]
D TOPB45_1598 pyruvate/ketoisovalerate oxidoreductase, gamma subunit K00172 porC; pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.1]
D TOPB45_1599 pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit K00171 porD; pyruvate ferredoxin oxidoreductase delta subunit [EC:1.2.7.1]
C 00030 Pentose phosphate pathway [PATH:top00030]
D TOPB45_0294 phosphoglucose isomerase (PGI) K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]
D TOPB45_0695 ribulose-phosphate 3-epimerase K01783 rpe; ribulose-phosphate 3-epimerase [EC:5.1.3.1]
D TOPB45_1400 1-deoxy-D-xylulose-5-phosphate synthase K00615 E2.2.1.1; transketolase [EC:2.2.1.1]
D TOPB45_0487 transaldolase K00616 TALDO1; transaldolase [EC:2.2.1.2]
D TOPB45_0014 sugar-phosphate isomerase, RpiB/LacA/LacB family K01808 rpiB; ribose 5-phosphate isomerase B [EC:5.3.1.6]
D TOPB45_1464 Ribonuclease H K01619 deoC; deoxyribose-phosphate aldolase [EC:4.1.2.4]
D TOPB45_0214 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III K15778 pmm-pgm; phosphomannomutase / phosphoglucomutase [EC:5.4.2.8 5.4.2.2]
D TOPB45_0075 ribose-phosphate pyrophosphokinase K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]
D TOPB45_0677 protein of unknown function DUF100 K01622 K01622; fructose 1,6-bisphosphate aldolase/phosphatase [EC:4.1.2.13 3.1.3.11]
D TOPB45_1305 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
C 00040 Pentose and glucuronate interconversions [PATH:top00040]
D TOPB45_1499 nucleotide sugar dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]
D TOPB45_1510 UTP--glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]
D TOPB45_0695 ribulose-phosphate 3-epimerase K01783 rpe; ribulose-phosphate 3-epimerase [EC:5.1.3.1]
C 00051 Fructose and mannose metabolism [PATH:top00051]
D TOPB45_0321 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase K16011 algA; mannose-1-phosphate guanylyltransferase / mannose-6-phosphate isomerase [EC:2.7.7.13 5.3.1.8]
D TOPB45_0214 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III K15778 pmm-pgm; phosphomannomutase / phosphoglucomutase [EC:5.4.2.8 5.4.2.2]
D TOPB45_1403 Nucleotidyl transferase K00966 GMPP; mannose-1-phosphate guanylyltransferase [EC:2.7.7.13]
D TOPB45_1305 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D TOPB45_0677 protein of unknown function DUF100 K01622 K01622; fructose 1,6-bisphosphate aldolase/phosphatase [EC:4.1.2.13 3.1.3.11]
D TOPB45_0104 triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]
D TOPB45_0014 sugar-phosphate isomerase, RpiB/LacA/LacB family K01808 rpiB; ribose 5-phosphate isomerase B [EC:5.3.1.6]
C 00052 Galactose metabolism [PATH:top00052]
D TOPB45_0401 UDP-glucose 4-epimerase K01784 galE; UDP-glucose 4-epimerase [EC:5.1.3.2]
D TOPB45_1510 UTP--glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]
D TOPB45_0214 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III K15778 pmm-pgm; phosphomannomutase / phosphoglucomutase [EC:5.4.2.8 5.4.2.2]
D TOPB45_0411 Glucokinase K00845 glk; glucokinase [EC:2.7.1.2]
D TOPB45_0338 UDP-galactopyranose mutase K01854 glf; UDP-galactopyranose mutase [EC:5.4.99.9]
D TOPB45_1305 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
C 00053 Ascorbate and aldarate metabolism [PATH:top00053]
D TOPB45_1499 nucleotide sugar dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]
D TOPB45_0660 UDP-glucuronate 5'-epimerase K08679 GAE; UDP-glucuronate 4-epimerase [EC:5.1.3.6]
C 00500 Starch and sucrose metabolism [PATH:top00500]
D TOPB45_1510 UTP--glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]
D TOPB45_0279 alpha-glucan phosphorylase K00688 PYG; glycogen phosphorylase [EC:2.4.1.1]
D TOPB45_0280 Alpha-amylase K07405 E3.2.1.1A; alpha-amylase [EC:3.2.1.1]
D TOPB45_0482 glycosyl transferase group 1 K13057 treT; trehalose synthase [EC:2.4.1.245]
D TOPB45_0484 HAD-superfamily hydrolase, subfamily IIB K16055 TPS; trehalose 6-phosphate synthase/phosphatase [EC:2.4.1.15 3.1.3.12]
D TOPB45_0214 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III K15778 pmm-pgm; phosphomannomutase / phosphoglucomutase [EC:5.4.2.8 5.4.2.2]
D TOPB45_0411 Glucokinase K00845 glk; glucokinase [EC:2.7.1.2]
D TOPB45_0294 phosphoglucose isomerase (PGI) K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]
C 00520 Amino sugar and nucleotide sugar metabolism [PATH:top00520]
D TOPB45_0235 Beta-N-acetylhexosaminidase K01207 nagZ; beta-N-acetylhexosaminidase [EC:3.2.1.52]
D TOPB45_1380 Glucosamine--fructose-6-phosphate aminotransferase (isomerizing) K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]
D TOPB45_1368 phosphoglucosamine mutase K03431 glmM; phosphoglucosamine mutase [EC:5.4.2.10]
D TOPB45_0254 hypothetical protein K04042 glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157]
D TOPB45_1404 aminoglycoside phosphotransferase K07102 amgK; N-acetylmuramate 1-kinase [EC:2.7.1.221]
D TOPB45_0844 UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]
D TOPB45_0945 UDP-N-acetylenolpyruvoylglucosamine reductase K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]
D TOPB45_1236 oxidoreductase domain protein K13020 wlbA; UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase [EC:1.1.1.335]
D TOPB45_1002 DegT/DnrJ/EryC1/StrS aminotransferase K13017 wbpE; UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase [EC:2.6.1.98]
D TOPB45_0411 Glucokinase K00845 glk; glucokinase [EC:2.7.1.2]
D TOPB45_0214 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III K15778 pmm-pgm; phosphomannomutase / phosphoglucomutase [EC:5.4.2.8 5.4.2.2]
D TOPB45_1510 UTP--glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]
D TOPB45_1499 nucleotide sugar dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]
D TOPB45_0401 UDP-glucose 4-epimerase K01784 galE; UDP-glucose 4-epimerase [EC:5.1.3.2]
D TOPB45_0338 UDP-galactopyranose mutase K01854 glf; UDP-galactopyranose mutase [EC:5.4.99.9]
D TOPB45_0660 UDP-glucuronate 5'-epimerase K08679 GAE; UDP-glucuronate 4-epimerase [EC:5.1.3.6]
D TOPB45_0294 phosphoglucose isomerase (PGI) K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]
D TOPB45_1403 Nucleotidyl transferase K00966 GMPP; mannose-1-phosphate guanylyltransferase [EC:2.7.7.13]
D TOPB45_0321 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase K16011 algA; mannose-1-phosphate guanylyltransferase / mannose-6-phosphate isomerase [EC:2.7.7.13 5.3.1.8]
C 00620 Pyruvate metabolism [PATH:top00620]
D TOPB45_0636 Acetate--CoA ligase K01895 ACSS1_2; acetyl-CoA synthetase [EC:6.2.1.1]
D TOPB45_1600 Pyruvate synthase K00169 porA; pyruvate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.1]
D TOPB45_1601 Pyruvate synthase K00170 porB; pyruvate ferredoxin oxidoreductase beta subunit [EC:1.2.7.1]
D TOPB45_1598 pyruvate/ketoisovalerate oxidoreductase, gamma subunit K00172 porC; pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.1]
D TOPB45_1599 pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit K00171 porD; pyruvate ferredoxin oxidoreductase delta subunit [EC:1.2.7.1]
D TOPB45_0672 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) K00174 korA; 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11]
D TOPB45_0671 2-oxoglutarate synthase K00175 korB; 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11]
D TOPB45_0244 Alcohol dehydrogenase (NADP(+)) K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
D TOPB45_1042 pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40]
D TOPB45_1273 Acetyl-CoA carboxylase K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]
D TOPB45_0712 Pyruvate carboxylase K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]
D TOPB45_0303 Acylphosphatase K01512 acyP; acylphosphatase [EC:3.6.1.7]
D TOPB45_0633 acetyl coenzyme A synthetase (ADP forming), alpha domain protein K24012 acdAB; acetate---CoA ligase (ADP-forming) [EC:6.2.1.13]
D TOPB45_0638 D-lactate dehydrogenase K03778 ldhA; D-lactate dehydrogenase [EC:1.1.1.28]
D TOPB45_1500 beta-lactamase domain-containing protein K01069 gloB; hydroxyacylglutathione hydrolase [EC:3.1.2.6]
D TOPB45_0713 Pyruvate carboxylase K01958 PC; pyruvate carboxylase [EC:6.4.1.1]
D TOPB45_0217 Malate dehydrogenase K00024 mdh; malate dehydrogenase [EC:1.1.1.37]
D TOPB45_0234 hydro-lyase, Fe-S type, tartrate/fumarate subfamily, alpha subunit K01677 E4.2.1.2AA; fumarate hydratase subunit alpha [EC:4.2.1.2]
D TOPB45_1624 hydro-lyase, Fe-S type, tartrate/fumarate subfamily, beta subunit K01678 E4.2.1.2AB; fumarate hydratase subunit beta [EC:4.2.1.2]
D TOPB45_1582 Phosphoenolpyruvate carboxylase K01595 ppc; phosphoenolpyruvate carboxylase [EC:4.1.1.31]
D TOPB45_1385 Pyruvate, phosphate dikinase K01006 ppdK; pyruvate, orthophosphate dikinase [EC:2.7.9.1]
D TOPB45_0109 phosphoenolpyruvate synthase K01007 pps; pyruvate, water dikinase [EC:2.7.9.2]
D TOPB45_0723 2-isopropylmalate synthase/homocitrate synthase family protein K01649 leuA; 2-isopropylmalate synthase [EC:2.3.3.13]
D TOPB45_0209 2-isopropylmalate synthase K01649 leuA; 2-isopropylmalate synthase [EC:2.3.3.13]
C 00630 Glyoxylate and dicarboxylate metabolism [PATH:top00630]
D TOPB45_0636 Acetate--CoA ligase K01895 ACSS1_2; acetyl-CoA synthetase [EC:6.2.1.1]
D TOPB45_0217 Malate dehydrogenase K00024 mdh; malate dehydrogenase [EC:1.1.1.37]
D TOPB45_1586 aconitate hydratase K01681 ACO; aconitate hydratase [EC:4.2.1.3]
D TOPB45_0002 D-lactate dehydrogenase (cytochrome) K00104 glcD; glycolate dehydrogenase FAD-linked subunit [EC:1.1.99.14]
D TOPB45_0829 protein of unknown function DUF224 cysteine-rich region domain protein K11473 glcF; glycolate dehydrogenase iron-sulfur subunit [EC:1.1.99.14]
D TOPB45_0181 Haloacid dehalogenase domain protein hydrolase K01091 gph; phosphoglycolate phosphatase [EC:3.1.3.18]
D TOPB45_1257 glutamine synthetase, type I K01915 glnA; glutamine synthetase [EC:6.3.1.2]
D TOPB45_0743 Glycine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]
D TOPB45_0675 Glycine cleavage system H protein K02437 gcvH; glycine cleavage system H protein
D TOPB45_0497 formate dehydrogenase, alpha subunit K00123 fdoG; formate dehydrogenase major subunit [EC:1.17.1.9]
D TOPB45_1449 formate dehydrogenase, alpha subunit K00123 fdoG; formate dehydrogenase major subunit [EC:1.17.1.9]
D TOPB45_0498 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein K00124 fdoH; formate dehydrogenase iron-sulfur subunit
D TOPB45_1450 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein K00124 fdoH; formate dehydrogenase iron-sulfur subunit
D TOPB45_1490 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein K00124 fdoH; formate dehydrogenase iron-sulfur subunit
C 00640 Propanoate metabolism [PATH:top00640]
D TOPB45_0636 Acetate--CoA ligase K01895 ACSS1_2; acetyl-CoA synthetase [EC:6.2.1.1]
D TOPB45_0633 acetyl coenzyme A synthetase (ADP forming), alpha domain protein K24012 acdAB; acetate---CoA ligase (ADP-forming) [EC:6.2.1.13]
D TOPB45_1600 Pyruvate synthase K00169 porA; pyruvate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.1]
D TOPB45_1601 Pyruvate synthase K00170 porB; pyruvate ferredoxin oxidoreductase beta subunit [EC:1.2.7.1]
D TOPB45_1598 pyruvate/ketoisovalerate oxidoreductase, gamma subunit K00172 porC; pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.1]
D TOPB45_1599 pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit K00171 porD; pyruvate ferredoxin oxidoreductase delta subunit [EC:1.2.7.1]
D TOPB45_1273 Acetyl-CoA carboxylase K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]
D TOPB45_0712 Pyruvate carboxylase K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]
C 00650 Butanoate metabolism [PATH:top00650]
D TOPB45_1600 Pyruvate synthase K00169 porA; pyruvate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.1]
D TOPB45_1601 Pyruvate synthase K00170 porB; pyruvate ferredoxin oxidoreductase beta subunit [EC:1.2.7.1]
D TOPB45_1598 pyruvate/ketoisovalerate oxidoreductase, gamma subunit K00172 porC; pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.1]
D TOPB45_1599 pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit K00171 porD; pyruvate ferredoxin oxidoreductase delta subunit [EC:1.2.7.1]
D TOPB45_0672 3-methyl-2-oxobutanoate dehydrogenase (ferredoxin) K00174 korA; 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit alpha [EC:1.2.7.3 1.2.7.11]
D TOPB45_0671 2-oxoglutarate synthase K00175 korB; 2-oxoglutarate/2-oxoacid ferredoxin oxidoreductase subunit beta [EC:1.2.7.3 1.2.7.11]
D TOPB45_1398 acetolactate synthase, large subunit, biosynthetic type K01652 E2.2.1.6L; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]
D TOPB45_1399 acetolactate synthase, small subunit K01653 E2.2.1.6S; acetolactate synthase I/III small subunit [EC:2.2.1.6]
C 00660 C5-Branched dibasic acid metabolism [PATH:top00660]
D TOPB45_1398 acetolactate synthase, large subunit, biosynthetic type K01652 E2.2.1.6L; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]
D TOPB45_1399 acetolactate synthase, small subunit K01653 E2.2.1.6S; acetolactate synthase I/III small subunit [EC:2.2.1.6]
D TOPB45_1287 3-isopropylmalate dehydratase large subunit K01703 leuC; 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35]
D TOPB45_1288 3-isopropylmalate dehydratase small subunit K01704 leuD; 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35]
D TOPB45_0906 3-isopropylmalate dehydrogenase K00052 leuB; 3-isopropylmalate dehydrogenase [EC:1.1.1.85]
C 00562 Inositol phosphate metabolism [PATH:top00562]
D TOPB45_0628 inositol monophosphatase K01092 E3.1.3.25; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]
D TOPB45_0371 Myo-inositol-1-phosphate synthase K01858 INO1; myo-inositol-1-phosphate synthase [EC:5.5.1.4]
D TOPB45_0104 triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]
B
B 09102 Energy metabolism
C 00190 Oxidative phosphorylation [PATH:top00190]
D TOPB45_0100 NAD(P)H-quinone oxidoreductase subunit 3 K00330 nuoA; NADH-quinone oxidoreductase subunit A [EC:7.1.1.2]
D TOPB45_0099 NAD(P)H-quinone oxidoreductase subunit K K00331 nuoB; NADH-quinone oxidoreductase subunit B [EC:7.1.1.2]
D TOPB45_0098 NAD(P)H-quinone oxidoreductase subunit J K00332 nuoC; NADH-quinone oxidoreductase subunit C [EC:7.1.1.2]
D TOPB45_0097 NAD(P)H-quinone oxidoreductase subunit H K00333 nuoD; NADH-quinone oxidoreductase subunit D [EC:7.1.1.2]
D TOPB45_0096 NAD(P)H-quinone oxidoreductase subunit 1 K00337 nuoH; NADH-quinone oxidoreductase subunit H [EC:7.1.1.2]
D TOPB45_0095 NAD(P)H-quinone oxidoreductase subunit I K00338 nuoI; NADH-quinone oxidoreductase subunit I [EC:7.1.1.2]
D TOPB45_0094 NADH-ubiquinone/plastoquinone oxidoreductase chain 6 K00339 nuoJ; NADH-quinone oxidoreductase subunit J [EC:7.1.1.2]
D TOPB45_0093 NAD(P)H-quinone oxidoreductase subunit 4L K00340 nuoK; NADH-quinone oxidoreductase subunit K [EC:7.1.1.2]
D TOPB45_0092 proton-translocating NADH-quinone oxidoreductase, chain L K00341 nuoL; NADH-quinone oxidoreductase subunit L [EC:7.1.1.2]
D TOPB45_0091 proton-translocating NADH-quinone oxidoreductase, chain M K00342 nuoM; NADH-quinone oxidoreductase subunit M [EC:7.1.1.2]
D TOPB45_0090 NAD(P)H-quinone oxidoreductase subunit 2 K00343 nuoN; NADH-quinone oxidoreductase subunit N [EC:7.1.1.2]
D TOPB45_1428 cytochrome bd ubiquinol oxidase subunit I K00425 cydA; cytochrome bd ubiquinol oxidase subunit I [EC:7.1.1.7]
D TOPB45_1427 cytochrome d ubiquinol oxidase, subunit II K00426 cydB; cytochrome bd ubiquinol oxidase subunit II [EC:7.1.1.7]
D TOPB45_1548 ATP synthase subunit alpha K02111 ATPF1A; F-type H+/Na+-transporting ATPase subunit alpha [EC:7.1.2.2 7.2.2.1]
D TOPB45_1546 ATP synthase subunit beta K02112 ATPF1B; F-type H+/Na+-transporting ATPase subunit beta [EC:7.1.2.2 7.2.2.1]
D TOPB45_1547 ATP synthase gamma chain K02115 ATPF1G; F-type H+-transporting ATPase subunit gamma
D TOPB45_1549 ATP synthase subunit delta K02113 ATPF1D; F-type H+-transporting ATPase subunit delta
D TOPB45_1545 ATP synthase epsilon chain K02114 ATPF1E; F-type H+-transporting ATPase subunit epsilon
D TOPB45_0879 ATP synthase subunit a K02108 ATPF0A; F-type H+-transporting ATPase subunit a
D TOPB45_1550 ATP synthase subunit b K02109 ATPF0B; F-type H+-transporting ATPase subunit b
D TOPB45_1551 H+transporting two-sector ATPase B/B' subunit K02109 ATPF0B; F-type H+-transporting ATPase subunit b
D TOPB45_0880 ATP synthase subunit c K02110 ATPF0C; F-type H+-transporting ATPase subunit c
D TOPB45_1536 Inorganic diphosphatase K15986 ppaC; manganese-dependent inorganic pyrophosphatase [EC:3.6.1.1]
C 00195 Photosynthesis
C 00196 Photosynthesis - antenna proteins
C 00710 Carbon fixation in photosynthetic organisms
C 00720 Carbon fixation pathways in prokaryotes
C 00680 Methane metabolism [PATH:top00680]
D TOPB45_0497 formate dehydrogenase, alpha subunit K00123 fdoG; formate dehydrogenase major subunit [EC:1.17.1.9]
D TOPB45_1449 formate dehydrogenase, alpha subunit K00123 fdoG; formate dehydrogenase major subunit [EC:1.17.1.9]
D TOPB45_0498 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein K00124 fdoH; formate dehydrogenase iron-sulfur subunit
D TOPB45_1450 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein K00124 fdoH; formate dehydrogenase iron-sulfur subunit
D TOPB45_1490 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein K00124 fdoH; formate dehydrogenase iron-sulfur subunit
D TOPB45_0393 CO dehydrogenase/acetyl-CoA synthase delta subunit, TIM barrel K00197 cdhE; acetyl-CoA decarbonylase/synthase, CODH/ACS complex subunit gamma [EC:2.1.1.245]
D TOPB45_0398 Carbon-monoxide dehydrogenase (acceptor) K00198 cooS; anaerobic carbon-monoxide dehydrogenase catalytic subunit [EC:1.2.7.4]
D TOPB45_0743 Glycine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]
D TOPB45_0128 Enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
D TOPB45_1582 Phosphoenolpyruvate carboxylase K01595 ppc; phosphoenolpyruvate carboxylase [EC:4.1.1.31]
D TOPB45_0217 Malate dehydrogenase K00024 mdh; malate dehydrogenase [EC:1.1.1.37]
D TOPB45_0677 protein of unknown function DUF100 K01622 K01622; fructose 1,6-bisphosphate aldolase/phosphatase [EC:4.1.2.13 3.1.3.11]
D TOPB45_1305 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D TOPB45_0636 Acetate--CoA ligase K01895 ACSS1_2; acetyl-CoA synthetase [EC:6.2.1.1]
D TOPB45_1600 Pyruvate synthase K00169 porA; pyruvate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.1]
D TOPB45_1601 Pyruvate synthase K00170 porB; pyruvate ferredoxin oxidoreductase beta subunit [EC:1.2.7.1]
D TOPB45_1598 pyruvate/ketoisovalerate oxidoreductase, gamma subunit K00172 porC; pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.1]
D TOPB45_1599 pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit K00171 porD; pyruvate ferredoxin oxidoreductase delta subunit [EC:1.2.7.1]
D TOPB45_0109 phosphoenolpyruvate synthase K01007 pps; pyruvate, water dikinase [EC:2.7.9.2]
D TOPB45_0850 phosphonopyruvate decarboxylase-related protein K15635 apgM; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]
D TOPB45_1613 proposed homoserine kinase K15635 apgM; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]
D TOPB45_0023 D-3-phosphoglycerate dehydrogenase K00058 serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]
C 00910 Nitrogen metabolism [PATH:top00910]
D TOPB45_0384 hypothetical protein K10535 hao; hydroxylamine dehydrogenase [EC:1.7.2.6]
D TOPB45_0551 hydroxylamine oxidase K10535 hao; hydroxylamine dehydrogenase [EC:1.7.2.6]
D TOPB45_1257 glutamine synthetase, type I K01915 glnA; glutamine synthetase [EC:6.3.1.2]
D TOPB45_1255 Glutamate synthase (ferredoxin) K00265 gltB; glutamate synthase (NADPH) large chain [EC:1.4.1.13]
C 00920 Sulfur metabolism [PATH:top00920]
D TOPB45_0179 sulfate adenylyltransferase K00958 sat; sulfate adenylyltransferase [EC:2.7.7.4]
D TOPB45_1076 phosphoesterase RecJ domain protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
D TOPB45_0176 adenylylsulfate reductase, alpha subunit K00394 aprA; adenylylsulfate reductase, subunit A [EC:1.8.99.2]
D TOPB45_0177 adenylylsulfate reductase, beta subunit K00395 aprB; adenylylsulfate reductase, subunit B [EC:1.8.99.2]
D TOPB45_0380 nitrite and sulphite reductase 4Fe-4S region K00385 asrC; anaerobic sulfite reductase subunit C
D TOPB45_1407 sulfite reductase, dissimilatory-type alpha subunit K11180 dsrA; dissimilatory sulfite reductase alpha subunit [EC:1.8.1.22]
D TOPB45_1406 sulfite reductase, dissimilatory-type beta subunit K11181 dsrB; dissimilatory sulfite reductase beta subunit [EC:1.8.1.22]
D TOPB45_1200 Nitrate reductase gamma subunit K27187 dsrM; [DsrC]-trisulfide reductase subunit M [EC:1.8.5.10]
D TOPB45_1201 DsrK protein K27188 dsrK; [DsrC]-trisulfide reductase subunit K [EC:1.8.5.10]
D TOPB45_1202 cytochrome c family protein K27189 dsrJ; [DsrC]-trisulfide reductase subunit J
D TOPB45_1203 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein K27190 dsrO; [DsrC]-trisulfide reductase subunit O
D TOPB45_1204 Polysulphide reductase NrfD K27191 dsrP; [DsrC]-trisulfide reductase subunit P
D TOPB45_0897 Nitrate reductase K08352 phsA; thiosulfate reductase / polysulfide reductase chain A [EC:1.8.5.5]
B
B 09103 Lipid metabolism
C 00061 Fatty acid biosynthesis [PATH:top00061]
D TOPB45_1273 Acetyl-CoA carboxylase K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15]
D TOPB45_0712 Pyruvate carboxylase K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14]
D TOPB45_0016 Acyl carrier protein K02078 acpP; acyl carrier protein
D TOPB45_0674 malonyl CoA-acyl carrier protein transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]
D TOPB45_0085 3-oxoacyl-(acyl-carrier-protein) synthase 3 K00648 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180]
D TOPB45_0015 3-oxoacyl-(acyl-carrier-protein) synthase 2 K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]
D TOPB45_1299 Beta-ketoacyl-acyl-carrier-protein synthase II K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]
D TOPB45_1597 3-oxoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
D TOPB45_0031 (3R)-hydroxymyristoyl-(acyl-carrier-protein) dehydratase K02372 fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]
D TOPB45_1300 o-succinylbenzoate--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
C 00062 Fatty acid elongation
C 00071 Fatty acid degradation [PATH:top00071]
D TOPB45_1300 o-succinylbenzoate--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
D TOPB45_1263 Acyl-(acyl-carrier-protein)--phospholipid O-acyltransferase K05939 aas; acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase / long-chain-fatty-acid--[acyl-carrier-protein] ligase [EC:2.3.1.40 6.2.1.20]
D TOPB45_0244 Alcohol dehydrogenase (NADP(+)) K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
C 00073 Cutin, suberine and wax biosynthesis
C 00100 Steroid biosynthesis
C 00120 Primary bile acid biosynthesis
C 00121 Secondary bile acid biosynthesis
C 00140 Steroid hormone biosynthesis
C 00561 Glycerolipid metabolism [PATH:top00561]
D TOPB45_0084 Phosphate acyltransferase K03621 plsX; phosphate acyltransferase [EC:2.3.1.274]
D TOPB45_1360 Glycerol-3-phosphate acyltransferase K08591 plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275]
D TOPB45_0373 1-acyl-sn-glycerol-3-phosphate acyltransferase K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]
C 00564 Glycerophospholipid metabolism [PATH:top00564]
D TOPB45_0602 Glycerol-3-phosphate dehydrogenase (NAD(P)+) K00057 gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94]
D TOPB45_1360 Glycerol-3-phosphate acyltransferase K08591 plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275]
D TOPB45_0373 1-acyl-sn-glycerol-3-phosphate acyltransferase K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]
D TOPB45_1263 Acyl-(acyl-carrier-protein)--phospholipid O-acyltransferase K05939 aas; acyl-[acyl-carrier-protein]-phospholipid O-acyltransferase / long-chain-fatty-acid--[acyl-carrier-protein] ligase [EC:2.3.1.40 6.2.1.20]
D TOPB45_1020 phosphatidate cytidylyltransferase K00981 E2.7.7.41; phosphatidate cytidylyltransferase [EC:2.7.7.41]
D TOPB45_1170 CDP-diacylglycerol/serine O-phosphatidyltransferase K17103 CHO1; CDP-diacylglycerol---serine O-phosphatidyltransferase [EC:2.7.8.8]
D TOPB45_1169 phosphatidylserine decarboxylase related protein K01613 psd; phosphatidylserine decarboxylase [EC:4.1.1.65]
D TOPB45_0882 CDP-alcohol phosphatidyltransferase K00995 pgsA; CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5]
D TOPB45_0607 phosphatidylglycerophosphatase A K01095 pgpA; phosphatidylglycerophosphatase A [EC:3.1.3.27]
D TOPB45_0518 CDP-alcohol phosphatidyltransferase K08744 CRLS; cardiolipin synthase (CMP-forming) [EC:2.7.8.41]
C 00565 Ether lipid metabolism
C 00600 Sphingolipid metabolism
C 00590 Arachidonic acid metabolism
C 00591 Linoleic acid metabolism
C 00592 alpha-Linolenic acid metabolism
C 01040 Biosynthesis of unsaturated fatty acids
B
B 09104 Nucleotide metabolism
C 00230 Purine metabolism [PATH:top00230]
D TOPB45_0214 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III K15778 pmm-pgm; phosphomannomutase / phosphoglucomutase [EC:5.4.2.8 5.4.2.2]
D TOPB45_0075 ribose-phosphate pyrophosphokinase K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1]
D TOPB45_0560 amidophosphoribosyltransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14]
D TOPB45_0998 Phosphoribosylamine--glycine ligase K01945 purD; phosphoribosylamine---glycine ligase [EC:6.3.4.13]
D TOPB45_0067 phosphoribosylformylglycinamidine synthase I K23265 purQ; phosphoribosylformylglycinamidine synthase subunit PurQ / glutaminase [EC:6.3.5.3 3.5.1.2]
D TOPB45_1303 Phosphoribosylformylglycinamidine synthase 2 K23270 purSL; phosphoribosylformylglycinamidine synthase subunit PurSL [EC:6.3.5.3]
D TOPB45_1282 phosphoribosylformylglycinamidine cyclo-ligase K01933 purM; phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1]
D TOPB45_0999 phosphoribosylaminoimidazole carboxylase, catalytic subunit K01588 purE; 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18]
D TOPB45_1045 Phosphoribosylaminoimidazole-succinocarboxamide synthase K01923 purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6]
D TOPB45_0192 adenylosuccinate lyase K01756 purB; adenylosuccinate lyase [EC:4.3.2.2]
D TOPB45_1505 Phosphoribosylaminoimidazolecarboxamide formyltransferase K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]
D TOPB45_0026 Phosphoribosylaminoimidazolecarboxamide formyltransferase K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]
D TOPB45_0530 Multifunctional protein surE K03787 surE; 5'/3'-nucleotidase [EC:3.1.3.5 3.1.3.6]
D TOPB45_0867 HAD-superfamily hydrolase, subfamily IA, variant 1 K20881 yrfG; GMP/IMP 5'-nucleotidase [EC:3.1.3.-]
D TOPB45_1162 purine nucleoside phosphorylase I, inosine and guanosine-specific K03783 punA; purine-nucleoside phosphorylase [EC:2.4.2.1]
D TOPB45_1148 Multi-copper polyphenol oxidoreductase, laccase K05810 LACC1; purine-nucleoside/S-methyl-5'-thioadenosine phosphorylase / adenosine deaminase [EC:2.4.2.1 2.4.2.28 3.5.4.4]
D TOPB45_1487 hypoxanthine phosphoribosyltransferase K00760 hprT; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8]
D TOPB45_0838 inosine-5'-monophosphate dehydrogenase K00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205]
D TOPB45_1011 Nucleoside diphosphate kinase K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
D TOPB45_1149 Nucleoside-triphosphatase rdgB K01519 rdgB; XTP/dITP diphosphohydrolase [EC:3.6.1.66]
D TOPB45_0079 GMP synthase (glutamine-hydrolyzing) K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]
D TOPB45_1172 Guanylate kinase K00942 gmk; guanylate kinase [EC:2.7.4.8]
D TOPB45_0985 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D TOPB45_0403 Deoxyguanosinetriphosphate triphosphohydrolase-like protein K01129 dgt; dGTPase [EC:3.1.5.1]
D TOPB45_1413 (p)ppGpp synthetase I, SpoT/RelA K01139 spoT; GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2]
D TOPB45_0837 Ppx/GppA phosphatase K01524 ppx-gppA; exopolyphosphatase / guanosine-5'-triphosphate,3'-diphosphate pyrophosphatase [EC:3.6.1.11 3.6.1.40]
D TOPB45_1271 Adenylosuccinate synthetase K01939 purA; adenylosuccinate synthase [EC:6.3.4.4]
D TOPB45_1595 Conserved hypothetical protein CHP00282 K09769 ymdB; 2',3'-cyclic-nucleotide 2'-phosphodiesterase [EC:3.1.4.16]
D TOPB45_0774 Adenylate kinase K00939 adk; adenylate kinase [EC:2.7.4.3]
D TOPB45_1289 MazG family protein K04765 mazG; nucleoside triphosphate diphosphatase [EC:3.6.1.9]
D TOPB45_1454 histidine triad (HIT) protein K19710 E2.7.7.53; ATP adenylyltransferase [EC:2.7.7.53]
D TOPB45_0179 sulfate adenylyltransferase K00958 sat; sulfate adenylyltransferase [EC:2.7.7.4]
C 00240 Pyrimidine metabolism [PATH:top00240]
D TOPB45_1276 carbamoyl-phosphate synthase, large subunit K01955 carB; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]
D TOPB45_0533 carbamoyl-phosphate synthase, small subunit K01956 carA; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]
D TOPB45_0261 Aspartate carbamoyltransferase K00609 pyrB; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2]
D TOPB45_0262 dihydroorotase, multifunctional complex type K01465 URA4; dihydroorotase [EC:3.5.2.3]
D TOPB45_0956 dihydroorotate dehydrogenase family protein K17828 pyrDI; dihydroorotate dehydrogenase (NAD+) catalytic subunit [EC:1.3.1.14]
D TOPB45_0957 Dihydroorotate dehydrogenase, electron transfer subunit, iron-sulfur cluster binding domain protein K02823 pyrDII; dihydroorotate dehydrogenase electron transfer subunit
D TOPB45_0524 Orotate phosphoribosyltransferase K00762 pyrE; orotate phosphoribosyltransferase [EC:2.4.2.10]
D TOPB45_1197 orotidine 5'-phosphate decarboxylase K01591 pyrF; orotidine-5'-phosphate decarboxylase [EC:4.1.1.23]
D TOPB45_1017 uridylate kinase K09903 pyrH; uridylate kinase [EC:2.7.4.22]
D TOPB45_1011 Nucleoside diphosphate kinase K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
D TOPB45_1289 MazG family protein K04765 mazG; nucleoside triphosphate diphosphatase [EC:3.6.1.9]
D TOPB45_1589 CTP synthase K01937 pyrG; CTP synthase [EC:6.3.4.2]
D TOPB45_1382 Cytidylate kinase K00945 cmk; CMP/dCMP kinase [EC:2.7.4.25]
D TOPB45_0530 Multifunctional protein surE K03787 surE; 5'/3'-nucleotidase [EC:3.1.3.5 3.1.3.6]
D TOPB45_1374 purine or other phosphorylase family 1 K00757 udp; uridine phosphorylase [EC:2.4.2.3]
D TOPB45_0285 Bifunctional protein pyrR K02825 pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9]
D TOPB45_1595 Conserved hypothetical protein CHP00282 K09769 ymdB; 2',3'-cyclic-nucleotide 2'-phosphodiesterase [EC:3.1.4.16]
D TOPB45_0985 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D TOPB45_0742 CMP/dCMP deaminase zinc-binding protein K01493 comEB; dCMP deaminase [EC:3.5.4.12]
D TOPB45_0197 Thymidylate kinase K00943 tmk; dTMP kinase [EC:2.7.4.9]
D TOPB45_1520 deoxyuridine 5'-triphosphate nucleotidohydrolase Dut K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D TOPB45_0290 thymidylate synthase, putative K00560 thyA; thymidylate synthase [EC:2.1.1.45]
B
B 09105 Amino acid metabolism
C 00250 Alanine, aspartate and glutamate metabolism [PATH:top00250]
D TOPB45_0681 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1]
D TOPB45_1216 Aspartate transaminase K11358 yhdR; aspartate aminotransferase [EC:2.6.1.1]
D TOPB45_1612 L-aspartate oxidase K00278 nadB; L-aspartate oxidase [EC:1.4.3.16]
D TOPB45_0509 hypothetical protein K01953 asnB; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]
D TOPB45_1561 tyrosine/nicotianamine aminotransferase K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]
D TOPB45_0486 Argininosuccinate synthase K01940 argG; argininosuccinate synthase [EC:6.3.4.5]
D TOPB45_1620 Argininosuccinate lyase K01755 argH; argininosuccinate lyase [EC:4.3.2.1]
D TOPB45_1271 Adenylosuccinate synthetase K01939 purA; adenylosuccinate synthase [EC:6.3.4.4]
D TOPB45_0192 adenylosuccinate lyase K01756 purB; adenylosuccinate lyase [EC:4.3.2.2]
D TOPB45_0261 Aspartate carbamoyltransferase K00609 pyrB; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2]
D TOPB45_1255 Glutamate synthase (ferredoxin) K00265 gltB; glutamate synthase (NADPH) large chain [EC:1.4.1.13]
D TOPB45_1257 glutamine synthetase, type I K01915 glnA; glutamine synthetase [EC:6.3.1.2]
D TOPB45_1276 carbamoyl-phosphate synthase, large subunit K01955 carB; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]
D TOPB45_0533 carbamoyl-phosphate synthase, small subunit K01956 carA; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]
D TOPB45_0067 phosphoribosylformylglycinamidine synthase I K23265 purQ; phosphoribosylformylglycinamidine synthase subunit PurQ / glutaminase [EC:6.3.5.3 3.5.1.2]
D TOPB45_1380 Glucosamine--fructose-6-phosphate aminotransferase (isomerizing) K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]
D TOPB45_0560 amidophosphoribosyltransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14]
C 00260 Glycine, serine and threonine metabolism [PATH:top00260]
D TOPB45_0724 aspartate kinase K00928 lysC; aspartate kinase [EC:2.7.2.4]
D TOPB45_1152 aspartate-semialdehyde dehydrogenase K00133 asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]
D TOPB45_0986 Homoserine dehydrogenase K00003 hom; homoserine dehydrogenase [EC:1.1.1.3]
D TOPB45_1556 threonine synthase K01733 thrC; threonine synthase [EC:4.2.3.1]
D TOPB45_0743 Glycine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]
D TOPB45_0850 phosphonopyruvate decarboxylase-related protein K15635 apgM; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]
D TOPB45_1613 proposed homoserine kinase K15635 apgM; 2,3-bisphosphoglycerate-independent phosphoglycerate mutase [EC:5.4.2.12]
D TOPB45_0023 D-3-phosphoglycerate dehydrogenase K00058 serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]
D TOPB45_0675 Glycine cleavage system H protein K02437 gcvH; glycine cleavage system H protein
D TOPB45_1170 CDP-diacylglycerol/serine O-phosphatidyltransferase K17103 CHO1; CDP-diacylglycerol---serine O-phosphatidyltransferase [EC:2.7.8.8]
D TOPB45_0450 Tryptophan synthase alpha chain K01695 trpA; tryptophan synthase alpha chain [EC:4.2.1.20]
D TOPB45_0449 Tryptophan synthase beta chain K01696 trpB; tryptophan synthase beta chain [EC:4.2.1.20]
D TOPB45_1251 Tryptophan synthase beta chain K06001 trpB; tryptophan synthase beta chain [EC:4.2.1.20]
C 00270 Cysteine and methionine metabolism [PATH:top00270]
D TOPB45_0620 S-adenosylmethionine synthase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6]
D TOPB45_0826 S-adenosylmethionine decarboxylase proenzyme K01611 speD; S-adenosylmethionine decarboxylase [EC:4.1.1.50]
D TOPB45_0230 S-adenosylmethionine decarboxylase related protein K01611 speD; S-adenosylmethionine decarboxylase [EC:4.1.1.50]
D TOPB45_0740 Spermidine synthase K00797 speE; spermidine synthase [EC:2.5.1.16]
D TOPB45_0231 Spermidine synthase K00797 speE; spermidine synthase [EC:2.5.1.16]
D TOPB45_1148 Multi-copper polyphenol oxidoreductase, laccase K05810 LACC1; purine-nucleoside/S-methyl-5'-thioadenosine phosphorylase / adenosine deaminase [EC:2.4.2.1 2.4.2.28 3.5.4.4]
D TOPB45_0635 5-methylthioadenosine/S-adenosylhomocysteine deaminase K12960 mtaD; 5-methylthioadenosine/S-adenosylhomocysteine deaminase [EC:3.5.4.31 3.5.4.28]
D TOPB45_1518 Methylthioribose-1-phosphate isomerase K08963 mtnA; methylthioribose-1-phosphate isomerase [EC:5.3.1.23]
D TOPB45_0621 Adenosylhomocysteinase K01251 AHCY; adenosylhomocysteinase [EC:3.13.2.1]
D TOPB45_0724 aspartate kinase K00928 lysC; aspartate kinase [EC:2.7.2.4]
D TOPB45_1152 aspartate-semialdehyde dehydrogenase K00133 asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]
D TOPB45_0986 Homoserine dehydrogenase K00003 hom; homoserine dehydrogenase [EC:1.1.1.3]
D TOPB45_0044 protein of unknown function DUF39 K23975 E2.8.1.16; L-aspartate semialdehyde sulfurtransferase [EC:2.8.1.16]
D TOPB45_1514 NIL domain-containing protein K23976 K23976; L-aspartate semialdehyde sulfurtransferase ferredoxin
D TOPB45_0503 branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42]
D TOPB45_0681 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1]
D TOPB45_1216 Aspartate transaminase K11358 yhdR; aspartate aminotransferase [EC:2.6.1.1]
D TOPB45_0217 Malate dehydrogenase K00024 mdh; malate dehydrogenase [EC:1.1.1.37]
D TOPB45_0023 D-3-phosphoglycerate dehydrogenase K00058 serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]
C 00280 Valine, leucine and isoleucine degradation [PATH:top00280]
D TOPB45_0503 branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42]
D TOPB45_0580 2-hydroxy-3-oxopropionate reductase K00020 HIBADH; 3-hydroxyisobutyrate dehydrogenase [EC:1.1.1.31]
C 00290 Valine, leucine and isoleucine biosynthesis [PATH:top00290]
D TOPB45_1287 3-isopropylmalate dehydratase large subunit K01703 leuC; 3-isopropylmalate/(R)-2-methylmalate dehydratase large subunit [EC:4.2.1.33 4.2.1.35]
D TOPB45_1288 3-isopropylmalate dehydratase small subunit K01704 leuD; 3-isopropylmalate/(R)-2-methylmalate dehydratase small subunit [EC:4.2.1.33 4.2.1.35]
D TOPB45_0906 3-isopropylmalate dehydrogenase K00052 leuB; 3-isopropylmalate dehydrogenase [EC:1.1.1.85]
D TOPB45_1398 acetolactate synthase, large subunit, biosynthetic type K01652 E2.2.1.6L; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]
D TOPB45_1399 acetolactate synthase, small subunit K01653 E2.2.1.6S; acetolactate synthase I/III small subunit [EC:2.2.1.6]
D TOPB45_0663 Ketol-acid reductoisomerase K00053 ilvC; ketol-acid reductoisomerase [EC:1.1.1.86]
D TOPB45_0036 Dihydroxy-acid dehydratase K01687 ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]
D TOPB45_0503 branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42]
D TOPB45_1561 tyrosine/nicotianamine aminotransferase K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]
D TOPB45_0723 2-isopropylmalate synthase/homocitrate synthase family protein K01649 leuA; 2-isopropylmalate synthase [EC:2.3.3.13]
D TOPB45_0209 2-isopropylmalate synthase K01649 leuA; 2-isopropylmalate synthase [EC:2.3.3.13]
C 00300 Lysine biosynthesis [PATH:top00300]
D TOPB45_0986 Homoserine dehydrogenase K00003 hom; homoserine dehydrogenase [EC:1.1.1.3]
D TOPB45_0724 aspartate kinase K00928 lysC; aspartate kinase [EC:2.7.2.4]
D TOPB45_1152 aspartate-semialdehyde dehydrogenase K00133 asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]
D TOPB45_0453 Dihydrodipicolinate synthase K01714 dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7]
D TOPB45_0133 Dihydrodipicolinate reductase K00215 dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]
D TOPB45_0138 Acetylornithine/succinyldiaminopimelate aminotransferase K00821 argD; acetylornithine/N-succinyldiaminopimelate aminotransferase [EC:2.6.1.11 2.6.1.17]
D TOPB45_0452 Diaminopimelate epimerase K01778 dapF; diaminopimelate epimerase [EC:5.1.1.7]
D TOPB45_0370 LL-diaminopimelate aminotransferase K10206 E2.6.1.83; LL-diaminopimelate aminotransferase [EC:2.6.1.83]
D TOPB45_0697 diaminopimelate decarboxylase K01586 lysA; diaminopimelate decarboxylase [EC:4.1.1.20]
D TOPB45_0939 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase K01928 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13]
D TOPB45_0940 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate/D-alanyl-D-alanyl ligase K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]
C 00310 Lysine degradation
C 00220 Arginine biosynthesis [PATH:top00220]
D TOPB45_1632 Ornithine carbamoyltransferase K00611 OTC; ornithine carbamoyltransferase [EC:2.1.3.3]
D TOPB45_0486 Argininosuccinate synthase K01940 argG; argininosuccinate synthase [EC:6.3.4.5]
D TOPB45_1620 Argininosuccinate lyase K01755 argH; argininosuccinate lyase [EC:4.3.2.1]
D TOPB45_0067 phosphoribosylformylglycinamidine synthase I K23265 purQ; phosphoribosylformylglycinamidine synthase subunit PurQ / glutaminase [EC:6.3.5.3 3.5.1.2]
D TOPB45_1257 glutamine synthetase, type I K01915 glnA; glutamine synthetase [EC:6.3.1.2]
D TOPB45_1276 carbamoyl-phosphate synthase, large subunit K01955 carB; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5]
D TOPB45_0533 carbamoyl-phosphate synthase, small subunit K01956 carA; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5]
D TOPB45_0681 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1]
D TOPB45_1216 Aspartate transaminase K11358 yhdR; aspartate aminotransferase [EC:2.6.1.1]
D TOPB45_1561 tyrosine/nicotianamine aminotransferase K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]
D TOPB45_1526 GCN5-related N-acetyltransferase K00619 argA; amino-acid N-acetyltransferase [EC:2.3.1.1]
D TOPB45_0529 Arginine biosynthesis bifunctional protein ArgJ K00620 argJ; glutamate N-acetyltransferase / amino-acid N-acetyltransferase [EC:2.3.1.35 2.3.1.1]
D TOPB45_1036 acetylglutamate kinase K00930 argB; acetylglutamate kinase [EC:2.7.2.8]
D TOPB45_0717 N-acetyl-gamma-glutamyl-phosphate reductase K00145 argC; N-acetyl-gamma-glutamyl-phosphate reductase [EC:1.2.1.38]
D TOPB45_0138 Acetylornithine/succinyldiaminopimelate aminotransferase K00821 argD; acetylornithine/N-succinyldiaminopimelate aminotransferase [EC:2.6.1.11 2.6.1.17]
D TOPB45_1218 peptidase dimerization domain protein K01438 argE; acetylornithine deacetylase [EC:3.5.1.16]
C 00330 Arginine and proline metabolism [PATH:top00330]
D TOPB45_0974 Creatininase K01470 E3.5.2.10; creatinine amidohydrolase [EC:3.5.2.10]
D TOPB45_0593 5-oxoprolinase (ATP-hydrolyzing) K01473 hyuA; N-methylhydantoinase A [EC:3.5.2.14]
D TOPB45_0594 5-oxoprolinase (ATP-hydrolyzing) K01474 hyuB; N-methylhydantoinase B [EC:3.5.2.14]
D TOPB45_0827 agmatinase K01480 speB; agmatinase [EC:3.5.3.11]
D TOPB45_0740 Spermidine synthase K00797 speE; spermidine synthase [EC:2.5.1.16]
D TOPB45_0231 Spermidine synthase K00797 speE; spermidine synthase [EC:2.5.1.16]
D TOPB45_0826 S-adenosylmethionine decarboxylase proenzyme K01611 speD; S-adenosylmethionine decarboxylase [EC:4.1.1.50]
D TOPB45_0230 S-adenosylmethionine decarboxylase related protein K01611 speD; S-adenosylmethionine decarboxylase [EC:4.1.1.50]
D TOPB45_0624 pyrroline-5-carboxylate reductase K00286 proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2]
D TOPB45_0432 Glutamate 5-kinase K00931 proB; glutamate 5-kinase [EC:2.7.2.11]
D TOPB45_0425 Gamma-glutamyl phosphate reductase K00147 proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]
D TOPB45_0681 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1]
D TOPB45_1216 Aspartate transaminase K11358 yhdR; aspartate aminotransferase [EC:2.6.1.1]
C 00340 Histidine metabolism [PATH:top00340]
D TOPB45_0584 ATP phosphoribosyltransferase K00765 hisG; ATP phosphoribosyltransferase [EC:2.4.2.17]
D TOPB45_0631 1-(5-phosphoribosyl)-5-((5-phosphoribosylamino)methylideneamino) imidazole-4-carboxamide isomerase K01814 hisA; phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase [EC:5.3.1.16]
D TOPB45_0690 Imidazole glycerol phosphate synthase subunit hisH K02501 hisH; imidazole glycerol-phosphate synthase subunit HisH [EC:4.3.2.10]
D TOPB45_0492 Imidazole glycerol phosphate synthase subunit hisF K02500 hisF; imidazole glycerol-phosphate synthase subunit HisF [EC:4.3.2.10]
D TOPB45_0719 Imidazoleglycerol-phosphate dehydratase K01693 hisB; imidazoleglycerol-phosphate dehydratase [EC:4.2.1.19]
D TOPB45_1156 Histidinol-phosphate aminotransferase K00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]
D TOPB45_1304 Histidinol dehydrogenase K00013 hisD; histidinol dehydrogenase [EC:1.1.1.23]
C 00350 Tyrosine metabolism [PATH:top00350]
D TOPB45_0681 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1]
D TOPB45_1216 Aspartate transaminase K11358 yhdR; aspartate aminotransferase [EC:2.6.1.1]
D TOPB45_1156 Histidinol-phosphate aminotransferase K00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]
D TOPB45_0244 Alcohol dehydrogenase (NADP(+)) K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
C 00360 Phenylalanine metabolism [PATH:top00360]
D TOPB45_0645 Phenylacetate--CoA ligase K01912 paaK; phenylacetate-CoA ligase [EC:6.2.1.30]
D TOPB45_0443 phenylacetic acid degradation-related protein K02614 paaI; acyl-CoA thioesterase [EC:3.1.2.-]
D TOPB45_0681 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1]
D TOPB45_1216 Aspartate transaminase K11358 yhdR; aspartate aminotransferase [EC:2.6.1.1]
D TOPB45_1156 Histidinol-phosphate aminotransferase K00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]
C 00380 Tryptophan metabolism
C 00400 Phenylalanine, tyrosine and tryptophan biosynthesis [PATH:top00400]
D TOPB45_0210 3-deoxy-7-phosphoheptulonate synthase K03856 AROA2; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54]
D TOPB45_0451 3-dehydroquinate synthase K01735 aroB; 3-dehydroquinate synthase [EC:4.2.3.4]
D TOPB45_1504 3-dehydroquinate dehydratase K03785 aroD; 3-dehydroquinate dehydratase I [EC:4.2.1.10]
D TOPB45_1503 Shikimate dehydrogenase K00014 aroE; shikimate dehydrogenase [EC:1.1.1.25]
D TOPB45_1501 Shikimate kinase K00891 aroK; shikimate kinase [EC:2.7.1.71]
D TOPB45_1502 3-phosphoshikimate 1-carboxyvinyltransferase K00800 aroA; 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19]
D TOPB45_1583 chorismate synthase K01736 aroC; chorismate synthase [EC:4.2.3.5]
D TOPB45_0375 anthranilate synthase component I K01657 trpE; anthranilate synthase component I [EC:4.1.3.27]
D TOPB45_0374 glutamine amidotransferase of anthranilate synthase K01658 trpG; anthranilate synthase component II [EC:4.1.3.27]
D TOPB45_0126 Anthranilate phosphoribosyltransferase K00766 trpD; anthranilate phosphoribosyltransferase [EC:2.4.2.18]
D TOPB45_0951 Phosphoribosylanthranilate isomerase K01817 trpF; phosphoribosylanthranilate isomerase [EC:5.3.1.24]
D TOPB45_0586 Indole-3-glycerol-phosphate synthase K01609 trpC; indole-3-glycerol phosphate synthase [EC:4.1.1.48]
D TOPB45_0450 Tryptophan synthase alpha chain K01695 trpA; tryptophan synthase alpha chain [EC:4.2.1.20]
D TOPB45_0449 Tryptophan synthase beta chain K01696 trpB; tryptophan synthase beta chain [EC:4.2.1.20]
D TOPB45_1251 Tryptophan synthase beta chain K06001 trpB; tryptophan synthase beta chain [EC:4.2.1.20]
D TOPB45_1476 prephenate dehydratase K14170 pheA; chorismate mutase / prephenate dehydratase [EC:5.4.99.5 4.2.1.51]
D TOPB45_0615 Prephenate dehydrogenase K04517 tyrA2; prephenate dehydrogenase [EC:1.3.1.12]
D TOPB45_0681 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1]
D TOPB45_1216 Aspartate transaminase K11358 yhdR; aspartate aminotransferase [EC:2.6.1.1]
D TOPB45_1156 Histidinol-phosphate aminotransferase K00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]
B
B 09106 Metabolism of other amino acids
C 00410 beta-Alanine metabolism [PATH:top00410]
D TOPB45_0204 Aspartate 1-decarboxylase K01579 panD; aspartate 1-decarboxylase [EC:4.1.1.11]
D TOPB45_0205 Pantothenate synthetase K01918 panC; pantoate--beta-alanine ligase [EC:6.3.2.1]
C 00430 Taurine and hypotaurine metabolism
C 00440 Phosphonate and phosphinate metabolism
C 00450 Selenocompound metabolism [PATH:top00450]
D TOPB45_0392 FAD-dependent pyridine nucleotide-disulfide oxidoreductase K00384 trxB; thioredoxin reductase (NADPH) [EC:1.8.1.9]
D TOPB45_1610 thioredoxin reductase K00384 trxB; thioredoxin reductase (NADPH) [EC:1.8.1.9]
D TOPB45_1617 Thioredoxin-disulfide reductase K00384 trxB; thioredoxin reductase (NADPH) [EC:1.8.1.9]
D TOPB45_0179 sulfate adenylyltransferase K00958 sat; sulfate adenylyltransferase [EC:2.7.7.4]
D TOPB45_1445 Selenide, water dikinase K01008 selD; selenide, water dikinase [EC:2.7.9.3]
D TOPB45_1560 L-seryl-tRNA(Sec) selenium transferase K01042 selA; L-seryl-tRNA(Ser) seleniumtransferase [EC:2.9.1.1]
D TOPB45_1186 Methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
C 00460 Cyanoamino acid metabolism
D TOPB45_0743 Glycine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]
C 00470 D-Amino acid metabolism [PATH:top00470]
D TOPB45_1616 Alanine racemase K01775 alr; alanine racemase [EC:5.1.1.1]
D TOPB45_1022 D-alanine--D-alanine ligase K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]
D TOPB45_0067 phosphoribosylformylglycinamidine synthase I K23265 purQ; phosphoribosylformylglycinamidine synthase subunit PurQ / glutaminase [EC:6.3.5.3 3.5.1.2]
D TOPB45_0137 Glutamate racemase K01776 murI; glutamate racemase [EC:5.1.1.3]
D TOPB45_0942 UDP-N-acetylmuramoylalanine--D-glutamate ligase K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9]
D TOPB45_0452 Diaminopimelate epimerase K01778 dapF; diaminopimelate epimerase [EC:5.1.1.7]
D TOPB45_0697 diaminopimelate decarboxylase K01586 lysA; diaminopimelate decarboxylase [EC:4.1.1.20]
C 00480 Glutathione metabolism [PATH:top00480]
D TOPB45_1434 isocitrate dehydrogenase, NADP-dependent K00031 IDH1; isocitrate dehydrogenase [EC:1.1.1.42]
D TOPB45_0740 Spermidine synthase K00797 speE; spermidine synthase [EC:2.5.1.16]
D TOPB45_0231 Spermidine synthase K00797 speE; spermidine synthase [EC:2.5.1.16]
B
B 09107 Glycan biosynthesis and metabolism
C 00510 N-Glycan biosynthesis
C 00513 Various types of N-glycan biosynthesis
C 00512 Mucin type O-glycan biosynthesis
C 00515 Mannose type O-glycan biosynthesis
C 00514 Other types of O-glycan biosynthesis
C 00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate
C 00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin
C 00533 Glycosaminoglycan biosynthesis - keratan sulfate
C 00531 Glycosaminoglycan degradation
C 00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis
C 00601 Glycosphingolipid biosynthesis - lacto and neolacto series
C 00603 Glycosphingolipid biosynthesis - globo and isoglobo series
C 00604 Glycosphingolipid biosynthesis - ganglio series
C 00511 Other glycan degradation
C 00540 Lipopolysaccharide biosynthesis [PATH:top00540]
D TOPB45_0030 Acyl-(acyl-carrier-protein)--UDP-N-acetylglucosamine O-acyltransferase K00677 lpxA; UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129]
D TOPB45_0263 UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase K02535 lpxC; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase [EC:3.5.1.108]
D TOPB45_0564 UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase K02536 lpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [EC:2.3.1.191]
D TOPB45_0029 protein of unknown function DUF1009 K09949 lpxI; UDP-2,3-diacylglucosamine hydrolase [EC:3.6.1.54]
D TOPB45_0027 lipid-A-disaccharide synthase K00748 lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182]
D TOPB45_1452 Tetraacyldisaccharide 4'-kinase K00912 lpxK; tetraacyldisaccharide 4'-kinase [EC:2.7.1.130]
D TOPB45_0196 KpsF/GutQ family protein K06041 kdsD; arabinose-5-phosphate isomerase [EC:5.3.1.13]
D TOPB45_0477 2-dehydro-3-deoxyphosphooctonate aldolase K01627 kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) [EC:2.5.1.55]
D TOPB45_0476 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) [EC:3.1.3.45]
D TOPB45_1080 3-deoxy-manno-octulosonate cytidylyltransferase K00979 kdsB; 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC:2.7.7.38]
D TOPB45_1147 Three-deoxy-D-manno-octulosonic-acid transferase domain-containing protein K02527 kdtA; 3-deoxy-D-manno-octulosonic-acid transferase [EC:2.4.99.12 2.4.99.13 2.4.99.14 2.4.99.15]
D TOPB45_0822 Phosphoheptose isomerase K03271 gmhA; D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28]
D TOPB45_0129 PfkB domain protein K21344 rfaE1; D-glycero-beta-D-manno-heptose-7-phosphate kinase [EC:2.7.1.167]
D TOPB45_1164 histidinol-phosphate phosphatase family protein K03273 gmhB; D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [EC:3.1.3.82 3.1.3.83]
D TOPB45_0300 rfaE bifunctional protein K21345 rfaE2; D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase [EC:2.7.7.70]
D TOPB45_1460 ADP-L-glycero-D-manno-heptose-6-epimerase K03274 gmhD; ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20]
D TOPB45_1165 lipopolysaccharide heptosyltransferase I K02841 waaC; lipopolysaccharide heptosyltransferase I [EC:2.4.99.23]
D TOPB45_0124 lipopolysaccharide heptosyltransferase II K02843 waaF; lipopolysaccharide heptosyltransferase II [EC:2.4.99.24]
D TOPB45_0511 O-antigen polymerase K02847 waaL; O-antigen ligase [EC:2.4.99.26]
C 00542 O-Antigen repeat unit biosynthesis
C 00541 O-Antigen nucleotide sugar biosynthesis [PATH:top00541]
D TOPB45_1510 UTP--glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9]
D TOPB45_0401 UDP-glucose 4-epimerase K01784 galE; UDP-glucose 4-epimerase [EC:5.1.3.2]
D TOPB45_0338 UDP-galactopyranose mutase K01854 glf; UDP-galactopyranose mutase [EC:5.4.99.9]
D TOPB45_1499 nucleotide sugar dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22]
D TOPB45_0660 UDP-glucuronate 5'-epimerase K08679 GAE; UDP-glucuronate 4-epimerase [EC:5.1.3.6]
D TOPB45_0351 glucose-1-phosphate thymidylyltransferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]
D TOPB45_0355 dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]
D TOPB45_0354 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]
D TOPB45_0356 dTDP-4-dehydrorhamnose reductase K00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]
D TOPB45_0321 mannose-1-phosphate guanylyltransferase/mannose-6-phosphate isomerase K16011 algA; mannose-1-phosphate guanylyltransferase / mannose-6-phosphate isomerase [EC:2.7.7.13 5.3.1.8]
D TOPB45_0254 hypothetical protein K04042 glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157]
D TOPB45_1236 oxidoreductase domain protein K13020 wlbA; UDP-N-acetyl-2-amino-2-deoxyglucuronate dehydrogenase [EC:1.1.1.335]
D TOPB45_1002 DegT/DnrJ/EryC1/StrS aminotransferase K13017 wbpE; UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase [EC:2.6.1.98]
C 00550 Peptidoglycan biosynthesis [PATH:top00550]
D TOPB45_0844 UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]
D TOPB45_0945 UDP-N-acetylenolpyruvoylglucosamine reductase K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]
D TOPB45_0944 UDP-N-acetylmuramate--L-alanine ligase K01924 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8]
D TOPB45_0942 UDP-N-acetylmuramoylalanine--D-glutamate ligase K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9]
D TOPB45_0939 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase K01928 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13]
D TOPB45_1022 D-alanine--D-alanine ligase K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]
D TOPB45_0940 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate/D-alanyl-D-alanyl ligase K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]
D TOPB45_1019 Undecaprenyl pyrophosphate synthase K00806 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31]
D TOPB45_0841 Undecaprenyl-diphosphatase K06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]
D TOPB45_0941 Phospho-N-acetylmuramoyl-pentapeptide-transferase K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]
D TOPB45_0943 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]
D TOPB45_0857 monofunctional biosynthetic peptidoglycan transglycosylase K03814 mtgA; monofunctional glycosyltransferase [EC:2.4.99.28]
D TOPB45_0239 penicillin-binding protein, 1A family K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4]
D TOPB45_1553 penicillin-binding protein 2 K05515 mrdA; penicillin-binding protein 2 [EC:3.4.16.4]
D TOPB45_1498 Serine-type D-Ala-D-Ala carboxypeptidase K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
D TOPB45_0623 beta-lactamase K21469 pbp4b; serine-type D-Ala-D-Ala carboxypeptidase [EC:3.4.16.4]
C 00552 Teichoic acid biosynthesis [PATH:top00552]
D TOPB45_0841 Undecaprenyl-diphosphatase K06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]
C 00571 Lipoarabinomannan (LAM) biosynthesis
C 00572 Arabinogalactan biosynthesis - Mycobacterium
C 00543 Exopolysaccharide biosynthesis
B
B 09108 Metabolism of cofactors and vitamins
C 00730 Thiamine metabolism [PATH:top00730]
D TOPB45_0286 Phosphomethylpyrimidine synthase K03147 thiC; phosphomethylpyrimidine synthase [EC:4.1.99.17]
D TOPB45_0595 Phosphomethylpyrimidine kinase K00941 thiD; hydroxymethylpyrimidine/phosphomethylpyrimidine kinase [EC:2.7.1.49 2.7.4.7]
D TOPB45_0236 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D TOPB45_1414 1-deoxy-D-xylulose-5-phosphate synthase K01662 dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]
D TOPB45_0915 thiazole biosynthetic enzyme K22699 thi4; sulfide-dependent adenosine diphosphate thiazole synthase [EC:2.4.2.59]
D TOPB45_0313 Thiamine-phosphate pyrophosphorylase K00788 thiE; thiamine-phosphate pyrophosphorylase [EC:2.5.1.3]
D TOPB45_1010 thiamine-monophosphate kinase K00946 thiL; thiamine-monophosphate kinase [EC:2.7.4.16]
D TOPB45_0774 Adenylate kinase K00939 adk; adenylate kinase [EC:2.7.4.3]
C 00740 Riboflavin metabolism [PATH:top00740]
D TOPB45_0960 GTP cyclohydrolase-2 K14652 ribBA; 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:4.1.99.12 3.5.4.25]
D TOPB45_0157 riboflavin biosynthesis protein RibD K11752 ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193]
D TOPB45_0639 Riboflavin-specific deaminase domain protein K14654 RIB7; 2,5-diamino-6-(ribosylamino)-4(3H)-pyrimidinone 5'-phosphate reductase [EC:1.1.1.302]
D TOPB45_0106 6,7-dimethyl-8-ribityllumazine synthase K00794 ribH; 6,7-dimethyl-8-ribityllumazine synthase [EC:2.5.1.78]
D TOPB45_0622 riboflavin synthase, alpha subunit K00793 ribE; riboflavin synthase [EC:2.5.1.9]
D TOPB45_0532 riboflavin biosynthesis protein RibF K11753 ribF; riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2]
D TOPB45_1463 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03186 ubiX; flavin prenyltransferase [EC:2.5.1.129]
C 00750 Vitamin B6 metabolism [PATH:top00750]
D TOPB45_1438 metalloprotease ybeY K03474 pdxJ; pyridoxine 5-phosphate synthase [EC:2.6.99.2]
D TOPB45_1556 threonine synthase K01733 thrC; threonine synthase [EC:4.2.3.1]
C 00760 Nicotinate and nicotinamide metabolism [PATH:top00760]
D TOPB45_1612 L-aspartate oxidase K00278 nadB; L-aspartate oxidase [EC:1.4.3.16]
D TOPB45_1591 Quinolinate synthase A K03517 nadA; quinolinate synthase [EC:2.5.1.72]
D TOPB45_1535 nicotinate-nucleotide pyrophosphorylase K00767 nadC; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19]
D TOPB45_0408 nicotinate phosphoribosyltransferase K00763 pncB; nicotinate phosphoribosyltransferase [EC:6.3.4.21]
D TOPB45_1162 purine nucleoside phosphorylase I, inosine and guanosine-specific K03783 punA; purine-nucleoside phosphorylase [EC:2.4.2.1]
D TOPB45_0530 Multifunctional protein surE K03787 surE; 5'/3'-nucleotidase [EC:3.1.3.5 3.1.3.6]
D TOPB45_0426 nicotinate-nucleotide adenylyltransferase K00969 nadD; nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18]
D TOPB45_1289 MazG family protein K04765 mazG; nucleoside triphosphate diphosphatase [EC:3.6.1.9]
D TOPB45_1256 NH(3)-dependent NAD(+) synthetase K01916 nadE; NAD+ synthase [EC:6.3.1.5]
D TOPB45_0407 isochorismatase hydrolase K08281 pncA; nicotinamidase/pyrazinamidase [EC:3.5.1.19 3.5.1.-]
D TOPB45_0494 NAD-dependent deacetylase K12410 cobB; NAD-dependent protein deacetylase/lipoamidase [EC:2.3.1.286 2.3.1.313]
D TOPB45_0276 inorganic polyphosphate/ATP-NAD kinase K00858 ppnK; NAD+ kinase [EC:2.7.1.23]
C 00770 Pantothenate and CoA biosynthesis [PATH:top00770]
D TOPB45_1398 acetolactate synthase, large subunit, biosynthetic type K01652 E2.2.1.6L; acetolactate synthase I/II/III large subunit [EC:2.2.1.6]
D TOPB45_1399 acetolactate synthase, small subunit K01653 E2.2.1.6S; acetolactate synthase I/III small subunit [EC:2.2.1.6]
D TOPB45_0663 Ketol-acid reductoisomerase K00053 ilvC; ketol-acid reductoisomerase [EC:1.1.1.86]
D TOPB45_0036 Dihydroxy-acid dehydratase K01687 ilvD; dihydroxy-acid dehydratase [EC:4.2.1.9]
D TOPB45_0548 3-methyl-2-oxobutanoate hydroxymethyltransferase K00606 panB; 3-methyl-2-oxobutanoate hydroxymethyltransferase [EC:2.1.2.11]
D TOPB45_0205 Pantothenate synthetase K01918 panC; pantoate--beta-alanine ligase [EC:6.3.2.1]
D TOPB45_1471 putative transcriptional acitvator, Baf family K03525 coaX; type III pantothenate kinase [EC:2.7.1.33]
D TOPB45_0422 phosphopantothenoylcysteine decarboxylase/phosphopantothenate/cysteine ligase K13038 coaBC; phosphopantothenoylcysteine decarboxylase / phosphopantothenate---cysteine ligase [EC:4.1.1.36 6.3.2.5]
D TOPB45_1289 MazG family protein K04765 mazG; nucleoside triphosphate diphosphatase [EC:3.6.1.9]
D TOPB45_1207 Phosphopantetheine adenylyltransferase K00954 E2.7.7.3A; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3]
D TOPB45_0158 Dephospho-CoA kinase K00859 coaE; dephospho-CoA kinase [EC:2.7.1.24]
D TOPB45_0013 Holo-(acyl-carrier-protein) synthase K00997 acpS; holo-[acyl-carrier protein] synthase [EC:2.7.8.7]
D TOPB45_0503 branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42]
D TOPB45_0204 Aspartate 1-decarboxylase K01579 panD; aspartate 1-decarboxylase [EC:4.1.1.11]
C 00780 Biotin metabolism [PATH:top00780]
D TOPB45_0015 3-oxoacyl-(acyl-carrier-protein) synthase 2 K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]
D TOPB45_1299 Beta-ketoacyl-acyl-carrier-protein synthase II K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]
D TOPB45_1597 3-oxoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
D TOPB45_0031 (3R)-hydroxymyristoyl-(acyl-carrier-protein) dehydratase K02372 fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]
D TOPB45_0470 biotin/acetyl-CoA-carboxylase ligase K03524 birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]
D TOPB45_1275 biotin/acetyl-CoA-carboxylase ligase K03524 birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]
C 00785 Lipoic acid metabolism
D TOPB45_0675 Glycine cleavage system H protein K02437 gcvH; glycine cleavage system H protein
C 00790 Folate biosynthesis [PATH:top00790]
D TOPB45_0461 protein of unknown function DUF198 K09007 folE2; GTP cyclohydrolase IB [EC:3.5.4.16]
D TOPB45_1607 NGG1p interacting factor 3 protein, NIF3 K22391 E3.5.4.16; GTP cyclohydrolase I [EC:3.5.4.16]
D TOPB45_0369 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950 folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3]
D TOPB45_1365 dihydropteroate synthase K00796 folP; dihydropteroate synthase [EC:2.5.1.15]
D TOPB45_1063 FolC bifunctional protein K11754 folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17]
D TOPB45_0960 GTP cyclohydrolase-2 K14652 ribBA; 3,4-dihydroxy 2-butanone 4-phosphate synthase / GTP cyclohydrolase II [EC:4.1.99.12 3.5.4.25]
D TOPB45_1346 queuosine biosynthesis protein QueD K01737 queD; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]
D TOPB45_1347 Radical SAM domain protein K10026 queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]
D TOPB45_1604 exsB protein K06920 queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]
D TOPB45_1307 NADPH-dependent 7-cyano-7-deazaguanine reductase K09457 queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13]
D TOPB45_0275 beta-lactamase domain protein K06897 K06897; 7,8-dihydropterin-6-yl-methyl-4-(beta-D-ribofuranosyl)aminobenzene 5'-phosphate synthase [EC:2.5.1.105]
D TOPB45_1188 molybdenum cofactor biosynthesis protein A K03639 moaA; GTP 3',8-cyclase [EC:4.1.99.22]
D TOPB45_0040 molybdenum cofactor biosynthesis protein C K03637 moaC; cyclic pyranopterin monophosphate synthase [EC:4.6.1.17]
D TOPB45_0520 molybdopterin biosynthesis MoaE protein K03635 MOCS2B; molybdopterin synthase catalytic subunit [EC:2.8.1.12]
D TOPB45_1444 molybdenum cofactor synthesis domain protein K03831 mogA; molybdopterin adenylyltransferase [EC:2.7.7.75]
D TOPB45_0496 molybdenum cofactor synthesis domain protein K03750 moeA; molybdopterin molybdotransferase [EC:2.10.1.1]
D TOPB45_0500 molybdenum cofactor synthesis domain protein K03750 moeA; molybdopterin molybdotransferase [EC:2.10.1.1]
D TOPB45_0112 Molybdopterin-guanine dinucleotide biosynthesis protein A K03752 mobA; molybdenum cofactor guanylyltransferase [EC:2.7.7.77]
C 00670 One carbon pool by folate [PATH:top00670]
D TOPB45_0399 Bifunctional protein folD K01491 folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9]
D TOPB45_0743 Glycine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1]
D TOPB45_1505 Phosphoribosylaminoimidazolecarboxamide formyltransferase K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]
D TOPB45_0026 Phosphoribosylaminoimidazolecarboxamide formyltransferase K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]
D TOPB45_1007 Methionyl-tRNA formyltransferase K00604 MTFMT; methionyl-tRNA formyltransferase [EC:2.1.2.9]
D TOPB45_0290 thymidylate synthase, putative K00560 thyA; thymidylate synthase [EC:2.1.1.45]
D TOPB45_0396 methylenetetrahydrofolate reductase K00297 metF; methylenetetrahydrofolate reductase (NADH) [EC:1.5.1.54]
D TOPB45_1544 5-formyltetrahydrofolate cyclo-ligase K01934 MTHFS; 5-formyltetrahydrofolate cyclo-ligase [EC:6.3.3.2]
C 00830 Retinol metabolism
C 00860 Porphyrin metabolism [PATH:top00860]
D TOPB45_1082 glutamyl-tRNA synthetase K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D TOPB45_0246 Glutamyl-tRNA reductase K02492 hemA; glutamyl-tRNA reductase [EC:1.2.1.70]
D TOPB45_0662 Glutamate-1-semialdehyde 2,1-aminomutase K01845 hemL; glutamate-1-semialdehyde 2,1-aminomutase [EC:5.4.3.8]
D TOPB45_0295 Porphobilinogen synthase K01698 hemB; porphobilinogen synthase [EC:4.2.1.24]
D TOPB45_1457 Porphobilinogen deaminase K01749 hemC; hydroxymethylbilane synthase [EC:2.5.1.61]
D TOPB45_1456 uroporphyrin-III C-methyltransferase K13542 cobA-hemD; uroporphyrinogen III methyltransferase / synthase [EC:2.1.1.107 4.2.1.75]
D TOPB45_0978 siroheme synthase K24866 sirC; precorrin-2 dehydrogenase [EC:1.3.1.76]
D TOPB45_0032 putative transcriptional regulator, AsnC family K22225 ahbAB; siroheme decarboxylase [EC:4.1.1.111]
D TOPB45_0798 putative transcriptional regulator, AsnC family K22225 ahbAB; siroheme decarboxylase [EC:4.1.1.111]
D TOPB45_0789 putative transcriptional regulator, AsnC family K22225 ahbAB; siroheme decarboxylase [EC:4.1.1.111]
D TOPB45_1506 Radical SAM domain protein K22226 ahbC; Fe-coproporphyrin III synthase
D TOPB45_0421 Radical SAM domain protein K22227 ahbD; AdoMet-dependent heme synthase [EC:1.3.98.6]
D TOPB45_1205 cobyrinic acid a,c-diamide synthase K02224 cobB-cbiA; cobyrinic acid a,c-diamide synthase [EC:6.3.5.9 6.3.5.11]
D TOPB45_0268 ATP:corrinoid adenosyltransferase BtuR/CobO/CobP K19221 cobA; cob(I)alamin adenosyltransferase [EC:2.5.1.17]
C 00130 Ubiquinone and other terpenoid-quinone biosynthesis [PATH:top00130]
D TOPB45_0221 4-hydroxybenzoate polyprenyltransferase K03179 ubiA; 4-hydroxybenzoate polyprenyltransferase [EC:2.5.1.39]
D TOPB45_0561 menaquinone biosynthesis decarboxylase, SCO4490 family K03182 ubiD; 4-hydroxy-3-polyprenylbenzoate decarboxylase [EC:4.1.1.98]
D TOPB45_1463 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03186 ubiX; flavin prenyltransferase [EC:2.5.1.129]
D TOPB45_0272 Ubiquinone/menaquinone biosynthesis methyltransferase ubiE K03183 ubiE; demethylmenaquinone methyltransferase / 2-methoxy-6-polyprenyl-1,4-benzoquinol methylase [EC:2.1.1.163 2.1.1.201]
D TOPB45_0271 protein of unknown function DUF178 K11782 mqnA; chorismate dehydratase [EC:4.2.1.151]
D TOPB45_0506 FO synthase, subunit 2 K18285 mqnE; aminodeoxyfutalosine synthase [EC:2.5.1.120]
D TOPB45_0270 S-adenosylhomocysteine deaminase K20810 mqnX; aminodeoxyfutalosine deaminase [EC:3.5.4.40]
D TOPB45_0116 purine or other phosphorylase family 1 K11783 mqnB; futalosine hydrolase [EC:3.2.2.26]
D TOPB45_0269 menaquinone biosynthesis protein K11784 mqnC; cyclic dehypoxanthinyl futalosine synthase [EC:1.21.98.1]
B
B 09109 Metabolism of terpenoids and polyketides
C 00900 Terpenoid backbone biosynthesis [PATH:top00900]
D TOPB45_1414 1-deoxy-D-xylulose-5-phosphate synthase K01662 dxs; 1-deoxy-D-xylulose-5-phosphate synthase [EC:2.2.1.7]
D TOPB45_0046 1-deoxy-D-xylulose 5-phosphate reductoisomerase K00099 dxr; 1-deoxy-D-xylulose-5-phosphate reductoisomerase [EC:1.1.1.267]
D TOPB45_1584 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase K00991 ispD; 2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase [EC:2.7.7.60]
D TOPB45_0074 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase K00919 ispE; 4-diphosphocytidyl-2-C-methyl-D-erythritol kinase [EC:2.7.1.148]
D TOPB45_0243 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase K01770 ispF; 2-C-methyl-D-erythritol 2,4-cyclodiphosphate synthase [EC:4.6.1.12]
D TOPB45_0387 4-hydroxy-3-methylbut-2-en-1-yl diphosphate synthase K03526 gcpE; (E)-4-hydroxy-3-methylbut-2-enyl-diphosphate synthase [EC:1.17.7.1 1.17.7.3]
D TOPB45_1463 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03186 ubiX; flavin prenyltransferase [EC:2.5.1.129]
D TOPB45_0979 NUDIX hydrolase K01823 idi; isopentenyl-diphosphate Delta-isomerase [EC:5.3.3.2]
D TOPB45_1415 Farnesyltranstransferase K13789 GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29]
D TOPB45_0180 Trans-hexaprenyltranstransferase K02523 ispB; octaprenyl-diphosphate synthase [EC:2.5.1.90]
D TOPB45_1019 Undecaprenyl pyrophosphate synthase K00806 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31]
D TOPB45_1473 peptidase M48 Ste24p K06013 STE24; STE24 endopeptidase [EC:3.4.24.84]
C 00902 Monoterpenoid biosynthesis
C 00909 Sesquiterpenoid and triterpenoid biosynthesis
C 00904 Diterpenoid biosynthesis
C 00906 Carotenoid biosynthesis
C 00905 Brassinosteroid biosynthesis
C 00981 Insect hormone biosynthesis
C 00908 Zeatin biosynthesis
C 00903 Limonene degradation
C 00907 Pinene, camphor and geraniol degradation
C 01052 Type I polyketide structures
C 00522 Biosynthesis of 12-, 14- and 16-membered macrolides
C 01051 Biosynthesis of ansamycins
D TOPB45_1400 1-deoxy-D-xylulose-5-phosphate synthase K00615 E2.2.1.1; transketolase [EC:2.2.1.1]
C 01059 Biosynthesis of enediyne antibiotics
C 01056 Biosynthesis of type II polyketide backbone
C 01057 Biosynthesis of type II polyketide products
C 00253 Tetracycline biosynthesis
C 00523 Polyketide sugar unit biosynthesis [PATH:top00523]
D TOPB45_0351 glucose-1-phosphate thymidylyltransferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]
D TOPB45_0355 dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]
D TOPB45_0354 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]
D TOPB45_0356 dTDP-4-dehydrorhamnose reductase K00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]
C 01054 Nonribosomal peptide structures
C 01053 Biosynthesis of siderophore group nonribosomal peptides
C 01055 Biosynthesis of vancomycin group antibiotics
D TOPB45_0355 dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]
B
B 09110 Biosynthesis of other secondary metabolites
C 00940 Phenylpropanoid biosynthesis
C 00945 Stilbenoid, diarylheptanoid and gingerol biosynthesis
C 00941 Flavonoid biosynthesis
C 00944 Flavone and flavonol biosynthesis
C 00942 Anthocyanin biosynthesis
C 00943 Isoflavonoid biosynthesis
C 00946 Degradation of flavonoids
C 00901 Indole alkaloid biosynthesis
C 00403 Indole diterpene alkaloid biosynthesis
C 00950 Isoquinoline alkaloid biosynthesis
C 00960 Tropane, piperidine and pyridine alkaloid biosynthesis
C 00996 Biosynthesis of various alkaloids
C 00232 Caffeine metabolism
C 00965 Betalain biosynthesis
C 00966 Glucosinolate biosynthesis
C 00402 Benzoxazinoid biosynthesis
C 00311 Penicillin and cephalosporin biosynthesis
C 00332 Carbapenem biosynthesis [PATH:top00332]
D TOPB45_0432 Glutamate 5-kinase K00931 proB; glutamate 5-kinase [EC:2.7.2.11]
D TOPB45_0425 Gamma-glutamyl phosphate reductase K00147 proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41]
C 00261 Monobactam biosynthesis [PATH:top00261]
D TOPB45_0179 sulfate adenylyltransferase K00958 sat; sulfate adenylyltransferase [EC:2.7.7.4]
D TOPB45_0724 aspartate kinase K00928 lysC; aspartate kinase [EC:2.7.2.4]
D TOPB45_1152 aspartate-semialdehyde dehydrogenase K00133 asd; aspartate-semialdehyde dehydrogenase [EC:1.2.1.11]
D TOPB45_0453 Dihydrodipicolinate synthase K01714 dapA; 4-hydroxy-tetrahydrodipicolinate synthase [EC:4.3.3.7]
D TOPB45_0133 Dihydrodipicolinate reductase K00215 dapB; 4-hydroxy-tetrahydrodipicolinate reductase [EC:1.17.1.8]
C 00331 Clavulanic acid biosynthesis
C 00521 Streptomycin biosynthesis [PATH:top00521]
D TOPB45_0411 Glucokinase K00845 glk; glucokinase [EC:2.7.1.2]
D TOPB45_0214 phosphoglucomutase/phosphomannomutase alpha/beta/alpha domain III K15778 pmm-pgm; phosphomannomutase / phosphoglucomutase [EC:5.4.2.8 5.4.2.2]
D TOPB45_0371 Myo-inositol-1-phosphate synthase K01858 INO1; myo-inositol-1-phosphate synthase [EC:5.5.1.4]
D TOPB45_0628 inositol monophosphatase K01092 E3.1.3.25; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25]
D TOPB45_0351 glucose-1-phosphate thymidylyltransferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]
D TOPB45_0355 dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]
D TOPB45_0354 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13]
D TOPB45_0356 dTDP-4-dehydrorhamnose reductase K00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133]
C 00524 Neomycin, kanamycin and gentamicin biosynthesis
D TOPB45_0411 Glucokinase K00845 glk; glucokinase [EC:2.7.1.2]
C 00525 Acarbose and validamycin biosynthesis [PATH:top00525]
D TOPB45_0351 glucose-1-phosphate thymidylyltransferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24]
D TOPB45_0355 dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46]
C 00401 Novobiocin biosynthesis [PATH:top00401]
D TOPB45_0615 Prephenate dehydrogenase K04517 tyrA2; prephenate dehydrogenase [EC:1.3.1.12]
D TOPB45_0681 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1]
D TOPB45_1216 Aspartate transaminase K11358 yhdR; aspartate aminotransferase [EC:2.6.1.1]
D TOPB45_1156 Histidinol-phosphate aminotransferase K00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]
C 00404 Staurosporine biosynthesis
C 00405 Phenazine biosynthesis
D TOPB45_0375 anthranilate synthase component I K01657 trpE; anthranilate synthase component I [EC:4.1.3.27]
D TOPB45_0374 glutamine amidotransferase of anthranilate synthase K01658 trpG; anthranilate synthase component II [EC:4.1.3.27]
C 00333 Prodigiosin biosynthesis
D TOPB45_0674 malonyl CoA-acyl carrier protein transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]
D TOPB45_1597 3-oxoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
C 00254 Aflatoxin biosynthesis
C 00998 Biosynthesis of various antibiotics
D TOPB45_0016 Acyl carrier protein K02078 acpP; acyl carrier protein
C 00999 Biosynthesis of various plant secondary metabolites [PATH:top00999]
D TOPB45_0620 S-adenosylmethionine synthase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6]
D TOPB45_1503 Shikimate dehydrogenase K00014 aroE; shikimate dehydrogenase [EC:1.1.1.25]
C 00997 Biosynthesis of various other secondary metabolites
B
B 09111 Xenobiotics biodegradation and metabolism
C 00362 Benzoate degradation
C 00627 Aminobenzoate degradation [PATH:top00627]
D TOPB45_0303 Acylphosphatase K01512 acyP; acylphosphatase [EC:3.6.1.7]
D TOPB45_1463 3-octaprenyl-4-hydroxybenzoate carboxy-lyase K03186 ubiX; flavin prenyltransferase [EC:2.5.1.129]
C 00364 Fluorobenzoate degradation
C 00625 Chloroalkane and chloroalkene degradation [PATH:top00625]
D TOPB45_0244 Alcohol dehydrogenase (NADP(+)) K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
C 00361 Chlorocyclohexane and chlorobenzene degradation
C 00623 Toluene degradation
C 00622 Xylene degradation
C 00633 Nitrotoluene degradation [PATH:top00633]
D TOPB45_0885 Cytochrome-c3 hydrogenase K06281 hyaB; hydrogenase large subunit [EC:1.12.99.6]
D TOPB45_0398 Carbon-monoxide dehydrogenase (acceptor) K00198 cooS; anaerobic carbon-monoxide dehydrogenase catalytic subunit [EC:1.2.7.4]
D TOPB45_1600 Pyruvate synthase K00169 porA; pyruvate ferredoxin oxidoreductase alpha subunit [EC:1.2.7.1]
D TOPB45_1601 Pyruvate synthase K00170 porB; pyruvate ferredoxin oxidoreductase beta subunit [EC:1.2.7.1]
D TOPB45_1598 pyruvate/ketoisovalerate oxidoreductase, gamma subunit K00172 porC; pyruvate ferredoxin oxidoreductase gamma subunit [EC:1.2.7.1]
D TOPB45_1599 pyruvate ferredoxin/flavodoxin oxidoreductase, delta subunit K00171 porD; pyruvate ferredoxin oxidoreductase delta subunit [EC:1.2.7.1]
D TOPB45_1407 sulfite reductase, dissimilatory-type alpha subunit K11180 dsrA; dissimilatory sulfite reductase alpha subunit [EC:1.8.1.22]
D TOPB45_1406 sulfite reductase, dissimilatory-type beta subunit K11181 dsrB; dissimilatory sulfite reductase beta subunit [EC:1.8.1.22]
C 00642 Ethylbenzene degradation
C 00643 Styrene degradation
C 00791 Atrazine degradation
C 00930 Caprolactam degradation
C 00363 Bisphenol degradation
C 00621 Dioxin degradation
C 00626 Naphthalene degradation [PATH:top00626]
D TOPB45_0244 Alcohol dehydrogenase (NADP(+)) K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1]
C 00624 Polycyclic aromatic hydrocarbon degradation
C 00365 Furfural degradation
C 00984 Steroid degradation
C 00980 Metabolism of xenobiotics by cytochrome P450
C 00982 Drug metabolism - cytochrome P450
C 00983 Drug metabolism - other enzymes
B
B 09112 Not included in regular maps
C 09113 Global maps only
#
A09120 Genetic Information Processing
B
B 09121 Transcription
C 03020 RNA polymerase [PATH:top03020]
D TOPB45_0164 DNA-directed RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
D TOPB45_0163 DNA-directed RNA polymerase subunit beta' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
D TOPB45_0781 DNA-directed RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
D TOPB45_0038 DNA-directed RNA polymerase subunit omega K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
C 03022 Basal transcription factors
C 03040 Spliceosome
B
B 09122 Translation
C 03010 Ribosome [PATH:top03010]
D TOPB45_0835 RNA binding S1 domain protein K02945 RP-S1; small subunit ribosomal protein S1
D TOPB45_1015 ribosomal protein S2 K02967 RP-S2; small subunit ribosomal protein S2
D TOPB45_0759 ribosomal protein S3 K02982 RP-S3; small subunit ribosomal protein S3
D TOPB45_0780 ribosomal protein S4 K02986 RP-S4; small subunit ribosomal protein S4
D TOPB45_0770 ribosomal protein S5 K02988 RP-S5; small subunit ribosomal protein S5
D TOPB45_0190 30S ribosomal protein S6 K02990 RP-S6; small subunit ribosomal protein S6
D TOPB45_0749 ribosomal protein S7 K02992 RP-S7; small subunit ribosomal protein S7
D TOPB45_0767 ribosomal protein S8 K02994 RP-S8; small subunit ribosomal protein S8
D TOPB45_0716 ribosomal protein S9 K02996 RP-S9; small subunit ribosomal protein S9
D TOPB45_0752 30S ribosomal protein S10 K02946 RP-S10; small subunit ribosomal protein S10
D TOPB45_0779 30S ribosomal protein S11 K02948 RP-S11; small subunit ribosomal protein S11
D TOPB45_0748 ribosomal protein S12 K02950 RP-S12; small subunit ribosomal protein S12
D TOPB45_0778 30S ribosomal protein S13 K02952 RP-S13; small subunit ribosomal protein S13
D TOPB45_0766 ribosomal protein S14 K02954 RP-S14; small subunit ribosomal protein S14
D TOPB45_0162 ribosomal protein S15 K02956 RP-S15; small subunit ribosomal protein S15
D TOPB45_0706 30S ribosomal protein S16 K02959 RP-S16; small subunit ribosomal protein S16
D TOPB45_0762 30S ribosomal protein S17 K02961 RP-S17; small subunit ribosomal protein S17
D TOPB45_0189 30S ribosomal protein S18 K02963 RP-S18; small subunit ribosomal protein S18
D TOPB45_0757 ribosomal protein S19 K02965 RP-S19; small subunit ribosomal protein S19
D TOPB45_1442 30S ribosomal protein S20 K02968 RP-S20; small subunit ribosomal protein S20
D TOPB45_0794 30S ribosomal protein S21 K02970 RP-S21; small subunit ribosomal protein S21
D TOPB45_0167 ribosomal protein L1 K02863 RP-L1; large subunit ribosomal protein L1
D TOPB45_0756 ribosomal protein L2 K02886 RP-L2; large subunit ribosomal protein L2
D TOPB45_0753 50S ribosomal protein L3 K02906 RP-L3; large subunit ribosomal protein L3
D TOPB45_0754 ribosomal protein L4/L1e K02926 RP-L4; large subunit ribosomal protein L4
D TOPB45_0765 ribosomal protein L5 K02931 RP-L5; large subunit ribosomal protein L5
D TOPB45_0768 ribosomal protein L6 K02933 RP-L6; large subunit ribosomal protein L6
D TOPB45_0165 50S ribosomal protein L7/L12 K02935 RP-L7; large subunit ribosomal protein L7/L12
D TOPB45_0188 50S ribosomal protein L9 K02939 RP-L9; large subunit ribosomal protein L9
D TOPB45_0166 50S ribosomal protein L10 K02864 RP-L10; large subunit ribosomal protein L10
D TOPB45_0168 ribosomal protein L11 K02867 RP-L11; large subunit ribosomal protein L11
D TOPB45_0715 ribosomal protein L13 K02871 RP-L13; large subunit ribosomal protein L13
D TOPB45_0763 ribosomal protein L14 K02874 RP-L14; large subunit ribosomal protein L14
D TOPB45_0772 ribosomal protein L15 K02876 RP-L15; large subunit ribosomal protein L15
D TOPB45_0760 50S ribosomal protein L16 K02878 RP-L16; large subunit ribosomal protein L16
D TOPB45_0782 50S ribosomal protein L17 K02879 RP-L17; large subunit ribosomal protein L17
D TOPB45_0769 ribosomal protein L18 K02881 RP-L18; large subunit ribosomal protein L18
D TOPB45_0981 50S ribosomal protein L19 K02884 RP-L19; large subunit ribosomal protein L19
D TOPB45_0546 50S ribosomal protein L20 K02887 RP-L20; large subunit ribosomal protein L20
D TOPB45_1358 50S ribosomal protein L21 K02888 RP-L21; large subunit ribosomal protein L21
D TOPB45_0758 ribosomal protein L22 K02890 RP-L22; large subunit ribosomal protein L22
D TOPB45_0755 Ribosomal protein L25/L23 K02892 RP-L23; large subunit ribosomal protein L23
D TOPB45_0764 ribosomal protein L24 K02895 RP-L24; large subunit ribosomal protein L24
D TOPB45_0076 50S ribosomal protein L25 K02897 RP-L25; large subunit ribosomal protein L25
D TOPB45_1359 50S ribosomal protein L27 K02899 RP-L27; large subunit ribosomal protein L27
D TOPB45_1412 50S ribosomal protein L28 K02902 RP-L28; large subunit ribosomal protein L28
D TOPB45_0761 ribosomal protein L29 K02904 RP-L29; large subunit ribosomal protein L29
D TOPB45_0771 ribosomal protein L30 K02907 RP-L30; large subunit ribosomal protein L30
D TOPB45_0253 50S ribosomal protein L31 K02909 RP-L31; large subunit ribosomal protein L31
D TOPB45_0083 50S ribosomal protein L32 K02911 RP-L32; large subunit ribosomal protein L32
D TOPB45_0171 50S ribosomal protein L33 K02913 RP-L33; large subunit ribosomal protein L33
D TOPB45_0587 50S ribosomal protein L34 K02914 RP-L34; large subunit ribosomal protein L34
D TOPB45_0547 50S ribosomal protein L35 K02916 RP-L35; large subunit ribosomal protein L35
D TOPB45_0777 50S ribosomal protein L36 K02919 RP-L36; large subunit ribosomal protein L36
D TOPB45_R0012 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D TOPB45_R0009 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D TOPB45_R0008 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA
C 00970 Aminoacyl-tRNA biosynthesis [PATH:top00970]
D TOPB45_R0010 tRNA-Ala K14218 tRNA-Ala; tRNA Ala
D TOPB45_R0013 tRNA-Ala K14218 tRNA-Ala; tRNA Ala
D TOPB45_R0045 tRNA-Ala K14218 tRNA-Ala; tRNA Ala
D TOPB45_R0042 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D TOPB45_R0035 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D TOPB45_R0047 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D TOPB45_R0014 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D TOPB45_R0031 tRNA-Asn K14220 tRNA-Asn; tRNA Asn
D TOPB45_R0033 tRNA-Asp K14221 tRNA-Asp; tRNA Asp
D TOPB45_R0044 tRNA-Cys K14222 tRNA-Cys; tRNA Cys
D TOPB45_R0017 tRNA-Gln K14223 tRNA-Gln; tRNA Gln
D TOPB45_R0024 tRNA-Gln K14223 tRNA-Gln; tRNA Gln
D TOPB45_R0051 tRNA-Glu K14224 tRNA-Glu; tRNA Glu
D TOPB45_R0027 tRNA-Glu K14224 tRNA-Glu; tRNA Glu
D TOPB45_R0004 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D TOPB45_R0046 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D TOPB45_R0049 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D TOPB45_R0036 tRNA-His K14226 tRNA-His; tRNA His
D TOPB45_R0011 tRNA-Ile K14227 tRNA-Ile; tRNA Ile
D TOPB45_R0001 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D TOPB45_R0028 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D TOPB45_R0015 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D TOPB45_R0037 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D TOPB45_R0029 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D TOPB45_R0025 tRNA-Lys K14229 tRNA-Lys; tRNA Lys
D TOPB45_R0050 tRNA-Lys K14229 tRNA-Lys; tRNA Lys
D TOPB45_R0052 tRNA-Met K14230 tRNA-Met; tRNA Met
D TOPB45_R0041 tRNA-Met K14230 tRNA-Met; tRNA Met
D TOPB45_R0043 tRNA-Met K14230 tRNA-Met; tRNA Met
D TOPB45_R0034 tRNA-Phe K14231 tRNA-Phe; tRNA Phe
D TOPB45_R0038 tRNA-Pro K14232 tRNA-Pro; tRNA Pro
D TOPB45_R0039 tRNA-Pro K14232 tRNA-Pro; tRNA Pro
D TOPB45_R0007 tRNA-Pro K14232 tRNA-Pro; tRNA Pro
D TOPB45_R0021 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D TOPB45_R0023 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D TOPB45_R0018 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D TOPB45_R0040 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D TOPB45_R0003 tRNA-Thr K14234 tRNA-Thr; tRNA Thr
D TOPB45_R0016 tRNA-Thr K14234 tRNA-Thr; tRNA Thr
D TOPB45_R0022 tRNA-Thr K14234 tRNA-Thr; tRNA Thr
D TOPB45_R0002 tRNA-Trp K14235 tRNA-Trp; tRNA Trp
D TOPB45_R0005 tRNA-Tyr K14236 tRNA-Tyr; tRNA Tyr
D TOPB45_R0032 tRNA-Val K14237 tRNA-Val; tRNA Val
D TOPB45_R0030 tRNA-Val K14237 tRNA-Val; tRNA Val
D TOPB45_R0006 tRNA-Val K14237 tRNA-Val; tRNA Val
D TOPB45_R0020 tRNA-Sec K14238 tRNA-Sec; tRNA Sec
D TOPB45_1082 glutamyl-tRNA synthetase K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D TOPB45_0597 Glutamyl-tRNA(Gln) amidotransferase subunit A K02433 gatA; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]
D TOPB45_1517 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B K02434 gatB; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]
D TOPB45_0596 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C K02435 gatC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]
D TOPB45_0619 alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D TOPB45_1293 aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D TOPB45_1283 Glycyl-tRNA synthetase alpha subunit K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]
D TOPB45_1284 Glycyl-tRNA synthetase beta subunit K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]
D TOPB45_0688 threonyl-tRNA synthetase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D TOPB45_1626 Seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D TOPB45_1560 L-seryl-tRNA(Sec) selenium transferase K01042 selA; L-seryl-tRNA(Ser) seleniumtransferase [EC:2.9.1.1]
D TOPB45_0721 cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D TOPB45_0265 cysteine synthase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D TOPB45_1186 Methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D TOPB45_1007 Methionyl-tRNA formyltransferase K00604 MTFMT; methionyl-tRNA formyltransferase [EC:2.1.2.9]
D TOPB45_1037 Valyl-tRNA synthetase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D TOPB45_1433 leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D TOPB45_0902 Isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D TOPB45_1576 Lysyl-tRNA synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D TOPB45_1528 Arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D TOPB45_0563 Prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
D TOPB45_0376 Histidyl-tRNA synthetase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D TOPB45_0545 Phenylalanyl-tRNA synthetase alpha chain K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D TOPB45_0544 Phenylalanyl-tRNA synthetase beta chain K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D TOPB45_1455 Tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D TOPB45_1131 tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
C 03013 Nucleocytoplasmic transport
C 03015 mRNA surveillance pathway
C 03008 Ribosome biogenesis in eukaryotes
B
B 09123 Folding, sorting and degradation
C 03060 Protein export [PATH:top03060]
D TOPB45_0773 preprotein translocase, SecY subunit K03076 secY; preprotein translocase subunit SecY
D TOPB45_0170 preprotein translocase, SecE subunit K03073 secE; preprotein translocase subunit SecE
D TOPB45_0045 preprotein translocase, SecG subunit K03075 secG; preprotein translocase subunit SecG
D TOPB45_1006 protein-export membrane protein SecD K12257 secDF; SecD/SecF fusion protein
D TOPB45_1214 preprotein translocase, YajC subunit K03210 yajC; preprotein translocase subunit YajC
D TOPB45_0590 Membrane protein oxaA K03217 yidC; YidC/Oxa1 family membrane protein insertase
D TOPB45_0122 Protein translocase subunit secA K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]
D TOPB45_0705 signal recognition particle protein K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4]
D TOPB45_R0019 ffs; SRP RNA; RNA component of signal recognition particle K01983 ffs; SRP RNA
D TOPB45_0416 signal recognition particle-docking protein FtsY K03110 ftsY; fused signal recognition particle receptor
D TOPB45_0307 arsenite-activated ATPase ArsA K01551 arsA; arsenite/tail-anchored protein-transporting ATPase [EC:7.3.2.7 7.3.-.-]
D TOPB45_1402 Sec-independent protein translocase protein tatA/E-like protein K03116 tatA; sec-independent protein translocase protein TatA
D TOPB45_1615 twin-arginine translocation protein, TatB subunit K03117 tatB; sec-independent protein translocase protein TatB
D TOPB45_1401 Sec-independent protein translocase, TatC subunit K03118 tatC; sec-independent protein translocase protein TatC
D TOPB45_0066 Sec-independent periplasmic protein translocase K03118 tatC; sec-independent protein translocase protein TatC
D TOPB45_1614 Sec-independent periplasmic protein translocase K03118 tatC; sec-independent protein translocase protein TatC
D TOPB45_1138 signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89]
D TOPB45_0903 Lipoprotein signal peptidase K03101 lspA; signal peptidase II [EC:3.4.23.36]
C 04141 Protein processing in endoplasmic reticulum
C 04130 SNARE interactions in vesicular transport
C 04120 Ubiquitin mediated proteolysis
C 04122 Sulfur relay system [PATH:top04122]
D TOPB45_0236 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D TOPB45_1240 SirA-like domain-containing protein K04085 tusA; tRNA 2-thiouridine synthesizing protein A [EC:2.8.1.-]
D TOPB45_1516 tRNA-specific 2-thiouridylase mnmA K00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]
D TOPB45_0929 tRNA methyl transferase K00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]
D TOPB45_0520 molybdopterin biosynthesis MoaE protein K03635 MOCS2B; molybdopterin synthase catalytic subunit [EC:2.8.1.12]
D TOPB45_1188 molybdenum cofactor biosynthesis protein A K03639 moaA; GTP 3',8-cyclase [EC:4.1.99.22]
D TOPB45_0040 molybdenum cofactor biosynthesis protein C K03637 moaC; cyclic pyranopterin monophosphate synthase [EC:4.6.1.17]
D TOPB45_1444 molybdenum cofactor synthesis domain protein K03831 mogA; molybdopterin adenylyltransferase [EC:2.7.7.75]
C 03050 Proteasome
C 03018 RNA degradation [PATH:top03018]
D TOPB45_0128 Enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
D TOPB45_1161 Polyribonucleotide nucleotidyltransferase K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]
D TOPB45_1154 ribonuclease R K12573 rnr; ribonuclease R [EC:3.1.13.1]
D TOPB45_0788 transcription termination factor Rho K03628 rho; transcription termination factor Rho
D TOPB45_1594 2,3 cyclic-nucleotide 2-phosphodiesterase K18682 rny; ribonucrease Y [EC:3.1.-.-]
D TOPB45_1305 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D TOPB45_1533 Chaperone protein dnaK K04043 dnaK; molecular chaperone DnaK
D TOPB45_1393 60 kDa chaperonin K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D TOPB45_0783 polynucleotide adenylyltransferase/metal dependent phosphohydrolase K00970 pcnB; poly(A) polymerase [EC:2.7.7.19]
B
B 09124 Replication and repair
C 03030 DNA replication [PATH:top03030]
D TOPB45_0433 DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
D TOPB45_0992 DNA polymerase III, subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D TOPB45_0845 DNA polymerase III, delta prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
D TOPB45_1043 DNA polymerase III delta K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
D TOPB45_1485 DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
D TOPB45_0187 replicative DNA helicase K02314 dnaB; replicative DNA helicase [EC:5.6.2.3]
D TOPB45_0796 DNA primase K02316 dnaG; DNA primase [EC:2.7.7.101]
D TOPB45_0245 single-strand binding protein K03111 ssb; single-strand DNA-binding protein
D TOPB45_0982 Ribonuclease H K03470 rnhB; ribonuclease HII [EC:3.1.26.4]
D TOPB45_0793 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
D TOPB45_1132 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
C 03410 Base excision repair [PATH:top03410]
D TOPB45_0617 endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D TOPB45_0070 formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
D TOPB45_1435 phage SPO1 DNA polymerase-related protein K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
D TOPB45_1295 phage SPO1 DNA polymerase-related protein K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
D TOPB45_0701 exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
D TOPB45_0793 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
D TOPB45_0402 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D TOPB45_1132 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
C 03420 Nucleotide excision repair [PATH:top03420]
D TOPB45_1357 transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
D TOPB45_0042 excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A
D TOPB45_1496 ABC transporter related protein K03701 uvrA; excinuclease ABC subunit A
D TOPB45_0309 UvrABC system protein B K03702 uvrB; excinuclease ABC subunit B
D TOPB45_0907 UvrABC system protein C K03703 uvrC; excinuclease ABC subunit C
D TOPB45_1355 UvrD/REP helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
D TOPB45_1033 UvrD/REP helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
D TOPB45_0793 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
D TOPB45_1132 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
C 03430 Mismatch repair [PATH:top03430]
D TOPB45_0427 DNA mismatch repair protein mutS K03555 mutS; DNA mismatch repair protein MutS
D TOPB45_0795 MutS2 protein K07456 mutS2; DNA mismatch repair protein MutS2
D TOPB45_0218 DNA mismatch repair protein mutL K03572 mutL; DNA mismatch repair protein MutL
D TOPB45_1355 UvrD/REP helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
D TOPB45_1033 UvrD/REP helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
D TOPB45_1417 Exodeoxyribonuclease 7 large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
D TOPB45_1416 Exodeoxyribonuclease 7 small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D TOPB45_0402 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D TOPB45_0245 single-strand binding protein K03111 ssb; single-strand DNA-binding protein
D TOPB45_0433 DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
D TOPB45_1485 DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
D TOPB45_0992 DNA polymerase III, subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D TOPB45_1043 DNA polymerase III delta K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
D TOPB45_0845 DNA polymerase III, delta prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
D TOPB45_1132 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
C 03440 Homologous recombination [PATH:top03440]
D TOPB45_0402 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D TOPB45_0245 single-strand binding protein K03111 ssb; single-strand DNA-binding protein
D TOPB45_0259 DNA repair protein recO K03584 recO; DNA repair protein RecO (recombination protein O)
D TOPB45_0994 Recombination protein recR K06187 recR; recombination protein RecR
D TOPB45_0130 Protein recA K03553 recA; recombination protein RecA
D TOPB45_0793 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
D TOPB45_0576 Holliday junction ATP-dependent DNA helicase ruvA K03550 ruvA; holliday junction DNA helicase RuvA
D TOPB45_0549 Holliday junction ATP-dependent DNA helicase ruvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
D TOPB45_0577 Crossover junction endodeoxyribonuclease ruvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D TOPB45_0614 ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
D TOPB45_0433 DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
D TOPB45_1485 DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
D TOPB45_0992 DNA polymerase III, subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D TOPB45_1043 DNA polymerase III delta K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
D TOPB45_0845 DNA polymerase III, delta prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
D TOPB45_1509 primosomal protein N' K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
C 03450 Non-homologous end-joining
C 03460 Fanconi anemia pathway
B
B 09126 Chromosome
C 03082 ATP-dependent chromatin remodeling
C 03083 Polycomb repressive complex
B
B 09125 Information processing in viruses
C 03230 Viral genome structure
C 03240 Viral replication
C 03250 Viral life cycle - HIV-1
C 03260 Virion - Human immunodeficiency virus
C 03271 Virion - Rotavirus
C 03262 Virion - Coronavirus
C 03261 Virion - Influenza virus
C 03263 Virion - Enterovirus
C 03264 Virion - Flavivirus
C 03265 Virion - Ebolavirus, Lyssavirus and Morbillivirus
C 03266 Virion - Herpesvirus
C 03268 Virion - Orthopoxvirus
C 03267 Virion - Adenovirus
C 03259 Virion - Bacteriophages T4 and T7
C 03258 Virion - Bacteriophage lambda
#
A09130 Environmental Information Processing
B
B 09131 Membrane transport
C 02010 ABC transporters [PATH:top02010]
D TOPB45_0933 molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 modA; molybdate transport system substrate-binding protein
D TOPB45_0932 ABC-type transporter, integral membrane subunit K02018 modB; molybdate transport system permease protein
D TOPB45_0931 Fe(3+)-transporting ATPase K02017 modC; molybdate transport system ATP-binding protein [EC:7.3.2.5]
D TOPB45_0033 Mammalian cell entry related domain protein K02067 mlaD; phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein
D TOPB45_0035 protein of unknown function DUF140 K02066 mlaE; phospholipid/cholesterol/gamma-HCH transport system permease protein
D TOPB45_0034 Fe(3+)-transporting ATPase K02065 mlaF; phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein
D TOPB45_0525 phosphate ABC transporter, periplasmic phosphate-binding protein K02040 pstS; phosphate transport system substrate-binding protein
D TOPB45_0526 phosphate ABC transporter, inner membrane subunit PstC K02037 pstC; phosphate transport system permease protein
D TOPB45_0527 phosphate ABC transporter, inner membrane subunit PstA K02038 pstA; phosphate transport system permease protein
D TOPB45_0528 phosphate ABC transporter, ATPase subunit K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1]
D TOPB45_1005 ABC-type metal ion transporter, periplasmic subunit K09815 znuA; zinc transport system substrate-binding protein
D TOPB45_1291 ABC-type transporter, integral membrane subunit K09816 znuB; zinc transport system permease protein
D TOPB45_1290 ABC transporter related protein K09817 znuC; zinc transport system ATP-binding protein [EC:7.2.2.20]
D TOPB45_1313 cobalamin (vitamin B12) biosynthesis CbiM protein K02007 cbiM; cobalt/nickel transport system permease protein
D TOPB45_1311 cobalt ABC transporter, inner membrane subunit CbiQ K02008 cbiQ; cobalt/nickel transport system permease protein
D TOPB45_1310 Fe(3+)-transporting ATPase K02006 cbiO; cobalt/nickel transport system ATP-binding protein
D TOPB45_0185 Nickel transport complex protein, NikM subunit, transmembrane K10094 cbiK; nickel transport protein
D TOPB45_0730 hypothetical protein K10094 cbiK; nickel transport protein
D TOPB45_1314 Nickel transport complex protein, NikM subunit, transmembrane K10094 cbiK; nickel transport protein
D TOPB45_1312 hypothetical protein K16915 cbiL; nickel transport protein
D TOPB45_0731 hypothetical protein K16915 cbiL; nickel transport protein
D TOPB45_1575 protein of unknown function DUF214 K09808 lolC_E; lipoprotein-releasing system permease protein
D TOPB45_1574 Phosphonate-transporting ATPase K09810 lolD; lipoprotein-releasing system ATP-binding protein [EC:7.6.2.-]
D TOPB45_0018 permease YjgP/YjgQ family protein K07091 lptF; lipopolysaccharide export system permease protein
D TOPB45_0017 permease YjgP/YjgQ family protein K11720 lptG; lipopolysaccharide export system permease protein
D TOPB45_1391 Sulfate-transporting ATPase K06861 lptB; lipopolysaccharide export system ATP-binding protein [EC:7.5.2.5]
D TOPB45_1278 Phosphonate-transporting ATPase K09812 ftsE; cell division transport system ATP-binding protein
D TOPB45_1166 Xenobiotic-transporting ATPase K11085 msbA; ATP-binding cassette, subfamily B, bacterial MsbA [EC:7.5.2.6]
C 02060 Phosphotransferase system (PTS)
C 03070 Bacterial secretion system [PATH:top03070]
D TOPB45_1071 outer membrane efflux protein K12340 tolC; outer membrane protein
D TOPB45_1006 protein-export membrane protein SecD K12257 secDF; SecD/SecF fusion protein
D TOPB45_0170 preprotein translocase, SecE subunit K03073 secE; preprotein translocase subunit SecE
D TOPB45_0045 preprotein translocase, SecG subunit K03075 secG; preprotein translocase subunit SecG
D TOPB45_0773 preprotein translocase, SecY subunit K03076 secY; preprotein translocase subunit SecY
D TOPB45_1214 preprotein translocase, YajC subunit K03210 yajC; preprotein translocase subunit YajC
D TOPB45_0590 Membrane protein oxaA K03217 yidC; YidC/Oxa1 family membrane protein insertase
D TOPB45_0122 Protein translocase subunit secA K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]
D TOPB45_0416 signal recognition particle-docking protein FtsY K03110 ftsY; fused signal recognition particle receptor
D TOPB45_0705 signal recognition particle protein K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4]
D TOPB45_1402 Sec-independent protein translocase protein tatA/E-like protein K03116 tatA; sec-independent protein translocase protein TatA
D TOPB45_1615 twin-arginine translocation protein, TatB subunit K03117 tatB; sec-independent protein translocase protein TatB
D TOPB45_1401 Sec-independent protein translocase, TatC subunit K03118 tatC; sec-independent protein translocase protein TatC
D TOPB45_0066 Sec-independent periplasmic protein translocase K03118 tatC; sec-independent protein translocase protein TatC
D TOPB45_1614 Sec-independent periplasmic protein translocase K03118 tatC; sec-independent protein translocase protein TatC
B
B 09132 Signal transduction
C 02020 Two-component system [PATH:top02020]
D TOPB45_0525 phosphate ABC transporter, periplasmic phosphate-binding protein K02040 pstS; phosphate transport system substrate-binding protein
D TOPB45_0257 protease Do K04771 degP; serine protease Do [EC:3.4.21.107]
D TOPB45_1345 flagellin domain protein K02406 fliC; flagellin
D TOPB45_1326 RNA polymerase, sigma 28 subunit, FliA/WhiG K02405 fliA; RNA polymerase sigma factor FliA
D TOPB45_1538 flagellar motor stator protein MotA K02556 motA; chemotaxis protein MotA
D TOPB45_0001 Chromosomal replication initiator protein dnaA K02313 dnaA; chromosomal replication initiator protein
D TOPB45_1260 nitrogen regulatory protein P-II K04751 glnB; nitrogen regulatory protein P-II 1
D TOPB45_1257 glutamine synthetase, type I K01915 glnA; glutamine synthetase [EC:6.3.1.2]
D TOPB45_0792 integral membrane sensor signal transduction histidine kinase K13598 ntrY; two-component system, NtrC family, nitrogen regulation sensor histidine kinase NtrY [EC:2.7.13.3]
D TOPB45_0824 two component, sigma54 specific, transcriptional regulator, Fis family K13599 ntrX; two-component system, NtrC family, nitrogen regulation response regulator NtrX
D TOPB45_1258 transcriptional regulator, NifA, Fis Family K02584 nifA; Nif-specific regulatory protein
D TOPB45_1390 RNA polymerase, sigma 54 subunit, RpoN K03092 rpoN; RNA polymerase sigma-54 factor
D TOPB45_0007 pilin K02650 pilA; type IV pilus assembly protein PilA
D TOPB45_0885 Cytochrome-c3 hydrogenase K06281 hyaB; hydrogenase large subunit [EC:1.12.99.6]
D TOPB45_1319 MCP methyltransferase, CheR-type K00575 cheR; chemotaxis protein methyltransferase CheR [EC:2.1.1.80]
D TOPB45_0550 methyl-accepting chemotaxis sensory transducer K03406 mcp; methyl-accepting chemotaxis protein
D TOPB45_1467 methyl-accepting chemotaxis sensory transducer K03406 mcp; methyl-accepting chemotaxis protein
D TOPB45_1468 CheW protein K03408 cheW; purine-binding chemotaxis protein CheW
D TOPB45_1469 CheA signal transduction histidine kinase K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
D TOPB45_1321 response regulator receiver protein K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
D TOPB45_1325 response regulator receiver protein K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
D TOPB45_1320 response regulator receiver modulated CheB methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
D TOPB45_0054 sigma54 specific transcriptional regulator, Fis family K10941 flrA; sigma-54 dependent transcriptional regulator, flagellar regulatory protein
D TOPB45_1428 cytochrome bd ubiquinol oxidase subunit I K00425 cydA; cytochrome bd ubiquinol oxidase subunit I [EC:7.1.1.7]
D TOPB45_1427 cytochrome d ubiquinol oxidase, subunit II K00426 cydB; cytochrome bd ubiquinol oxidase subunit II [EC:7.1.1.7]
D TOPB45_1071 outer membrane efflux protein K12340 tolC; outer membrane protein
D TOPB45_0299 flagellar biosynthesis anti-sigma factor protein FlgM K02398 flgM; negative regulator of flagellin synthesis FlgM
C 04010 MAPK signaling pathway
C 04013 MAPK signaling pathway - fly
C 04016 MAPK signaling pathway - plant
C 04011 MAPK signaling pathway - yeast
C 04012 ErbB signaling pathway
C 04014 Ras signaling pathway
C 04015 Rap1 signaling pathway
C 04310 Wnt signaling pathway
C 04330 Notch signaling pathway
C 04340 Hedgehog signaling pathway
C 04341 Hedgehog signaling pathway - fly
C 04350 TGF-beta signaling pathway
C 04390 Hippo signaling pathway
C 04391 Hippo signaling pathway - fly
C 04392 Hippo signaling pathway - multiple species
C 04370 VEGF signaling pathway
C 04371 Apelin signaling pathway
C 04630 JAK-STAT signaling pathway
C 04064 NF-kappa B signaling pathway
C 04668 TNF signaling pathway
C 04066 HIF-1 signaling pathway
C 04068 FoxO signaling pathway
C 04020 Calcium signaling pathway
C 04070 Phosphatidylinositol signaling system
C 04072 Phospholipase D signaling pathway
C 04071 Sphingolipid signaling pathway
C 04024 cAMP signaling pathway
C 04022 cGMP-PKG signaling pathway
C 04151 PI3K-Akt signaling pathway
C 04152 AMPK signaling pathway
C 04150 mTOR signaling pathway
C 04075 Plant hormone signal transduction
B
B 09133 Signaling molecules and interaction
C 04080 Neuroactive ligand-receptor interaction
C 04060 Cytokine-cytokine receptor interaction
C 04061 Viral protein interaction with cytokine and cytokine receptor
C 04512 ECM-receptor interaction
C 04514 Cell adhesion molecules
#
A09140 Cellular Processes
B
B 09141 Transport and catabolism
C 04144 Endocytosis
C 04145 Phagosome
C 04142 Lysosome
C 04146 Peroxisome
C 04140 Autophagy - animal
C 04138 Autophagy - yeast
C 04136 Autophagy - other
C 04137 Mitophagy - animal
C 04139 Mitophagy - yeast
C 04148 Efferocytosis
B
B 09143 Cell growth and death
C 04110 Cell cycle
C 04111 Cell cycle - yeast
C 04112 Cell cycle - Caulobacter
C 04113 Meiosis - yeast
C 04114 Oocyte meiosis
C 04210 Apoptosis
C 04214 Apoptosis - fly
C 04215 Apoptosis - multiple species
C 04216 Ferroptosis
C 04217 Necroptosis
C 04115 p53 signaling pathway
C 04218 Cellular senescence
B
B 09144 Cellular community - eukaryotes
C 04510 Focal adhesion
C 04520 Adherens junction
C 04530 Tight junction
C 04540 Gap junction
C 04550 Signaling pathways regulating pluripotency of stem cells
B
B 09145 Cellular community - prokaryotes
C 02024 Quorum sensing [PATH:top02024]
D TOPB45_0375 anthranilate synthase component I K01657 trpE; anthranilate synthase component I [EC:4.1.3.27]
D TOPB45_0374 glutamine amidotransferase of anthranilate synthase K01658 trpG; anthranilate synthase component II [EC:4.1.3.27]
D TOPB45_0341 glycosyl transferase family 2 K12990 rfbF; rhamnosyltransferase [EC:2.4.1.-]
D TOPB45_1300 o-succinylbenzoate--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
D TOPB45_0157 riboflavin biosynthesis protein RibD K11752 ribD; diaminohydroxyphosphoribosylaminopyrimidine deaminase / 5-amino-6-(5-phosphoribosylamino)uracil reductase [EC:3.5.4.26 1.1.1.193]
D TOPB45_0228 RND efflux system, outer membrane lipoprotein, NodT family K18139 oprM; outer membrane protein, multidrug efflux system
D TOPB45_0603 ABC-type transporter, periplasmic subunit K02035 ABC.PE.S; peptide/nickel transport system substrate-binding protein
D TOPB45_0049 ABC-type transporter, integral membrane subunit K02033 ABC.PE.P; peptide/nickel transport system permease protein
D TOPB45_0050 ABC-type transporter, integral membrane subunit K02034 ABC.PE.P1; peptide/nickel transport system permease protein
D TOPB45_1634 oligopeptide/dipeptide ABC transporter, ATPase subunit K02031 ddpD; peptide/nickel transport system ATP-binding protein
D TOPB45_0590 Membrane protein oxaA K03217 yidC; YidC/Oxa1 family membrane protein insertase
D TOPB45_1006 protein-export membrane protein SecD K12257 secDF; SecD/SecF fusion protein
D TOPB45_0170 preprotein translocase, SecE subunit K03073 secE; preprotein translocase subunit SecE
D TOPB45_0045 preprotein translocase, SecG subunit K03075 secG; preprotein translocase subunit SecG
D TOPB45_0773 preprotein translocase, SecY subunit K03076 secY; preprotein translocase subunit SecY
D TOPB45_1214 preprotein translocase, YajC subunit K03210 yajC; preprotein translocase subunit YajC
D TOPB45_0122 Protein translocase subunit secA K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]
D TOPB45_0416 signal recognition particle-docking protein FtsY K03110 ftsY; fused signal recognition particle receptor
D TOPB45_0705 signal recognition particle protein K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4]
C 05111 Biofilm formation - Vibrio cholerae
C 02025 Biofilm formation - Pseudomonas aeruginosa
C 02026 Biofilm formation - Escherichia coli
B
B 09142 Cell motility
C 02030 Bacterial chemotaxis [PATH:top02030]
D TOPB45_0550 methyl-accepting chemotaxis sensory transducer K03406 mcp; methyl-accepting chemotaxis protein
D TOPB45_1467 methyl-accepting chemotaxis sensory transducer K03406 mcp; methyl-accepting chemotaxis protein
D TOPB45_1469 CheA signal transduction histidine kinase K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
D TOPB45_1468 CheW protein K03408 cheW; purine-binding chemotaxis protein CheW
D TOPB45_1321 response regulator receiver protein K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
D TOPB45_1325 response regulator receiver protein K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
D TOPB45_1466 hypothetical protein K03409 cheX; chemotaxis protein CheX
D TOPB45_1320 response regulator receiver modulated CheB methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
D TOPB45_1319 MCP methyltransferase, CheR-type K00575 cheR; chemotaxis protein methyltransferase CheR [EC:2.1.1.80]
D TOPB45_0061 flagellar motor switch protein FliG K02410 fliG; flagellar motor switch protein FliG
D TOPB45_1336 flagellar motor switch protein FliM K02416 fliM; flagellar motor switch protein FliM
D TOPB45_1335 flagellar motor switch protein FliN K02417 fliN; flagellar motor switch protein FliN
D TOPB45_1538 flagellar motor stator protein MotA K02556 motA; chemotaxis protein MotA
D TOPB45_1539 OmpA/MotB domain protein K02557 motB; chemotaxis protein MotB
C 02040 Flagellar assembly [PATH:top02040]
D TOPB45_0059 Flagellar hook-basal body complex protein fliE K02408 fliE; flagellar hook-basal body complex protein FliE
D TOPB45_0060 flagellar M-ring protein FliF K02409 fliF; flagellar M-ring protein FliF
D TOPB45_0061 flagellar motor switch protein FliG K02410 fliG; flagellar motor switch protein FliG
D TOPB45_0062 Flagellar assembly protein FliH/Type III secretion system HrpE K02411 fliH; flagellar assembly protein FliH
D TOPB45_0063 ATPase, FliI/YscN family K02412 fliI; flagellum-specific ATP synthase [EC:7.4.2.8]
D TOPB45_0064 hypothetical protein K02413 fliJ; flagellar protein FliJ
D TOPB45_0089 hypothetical protein K02414 fliK; flagellar hook-length control protein FliK
D TOPB45_1337 flagellar basal body-associated protein FliL K02415 fliL; flagellar protein FliL
D TOPB45_1336 flagellar motor switch protein FliM K02416 fliM; flagellar motor switch protein FliM
D TOPB45_1335 flagellar motor switch protein FliN K02417 fliN; flagellar motor switch protein FliN
D TOPB45_1334 hypothetical protein K02418 fliO; flagellar protein FliO/FliZ
D TOPB45_1333 flagellar biosynthetic protein FliP K02419 fliP; flagellar biosynthesis protein FliP
D TOPB45_1332 flagellar biosynthetic protein FliQ K02420 fliQ; flagellar biosynthesis protein FliQ
D TOPB45_1331 type III secretion system inner membrane R protein K02421 fliR; flagellar biosynthesis protein FliR
D TOPB45_1329 flagellar biosynthesis protein FlhA K02400 flhA; flagellar biosynthesis protein FlhA
D TOPB45_1330 flagellar biosynthetic protein FlhB K02401 flhB; flagellar biosynthesis protein FlhB
D TOPB45_1570 flagella basal body P-ring formation protein FlgA K02386 flgA; flagellar basal body P-ring formation protein FlgA
D TOPB45_0057 flagellar basal-body rod protein FlgB K02387 flgB; flagellar basal-body rod protein FlgB
D TOPB45_0058 flagellar basal-body rod protein FlgC K02388 flgC; flagellar basal-body rod protein FlgC
D TOPB45_0088 flagellar hook capping protein K02389 flgD; flagellar basal-body rod modification protein FlgD
D TOPB45_0087 flagellar hook-basal body protein K02390 flgE; flagellar hook protein FlgE
D TOPB45_0086 flagellar hook-basal body protein K02390 flgE; flagellar hook protein FlgE
D TOPB45_1572 flagellar basal-body rod protein FlgF K02391 flgF; flagellar basal-body rod protein FlgF
D TOPB45_1571 flagellar basal-body rod protein FlgG K02392 flgG; flagellar basal-body rod protein FlgG
D TOPB45_1569 Flagellar L-ring protein K02393 flgH; flagellar L-ring protein FlgH
D TOPB45_1568 Flagellar P-ring protein K02394 flgI; flagellar P-ring protein FlgI
D TOPB45_1567 hypothetical protein K02395 flgJ; peptidoglycan hydrolase FlgJ
D TOPB45_1565 flagellar hook-associated protein FlgK K02396 flgK; flagellar hook-associated protein 1
D TOPB45_1564 flagellar hook-associated protein 3 K02397 flgL; flagellar hook-associated protein 3 FlgL
D TOPB45_1345 flagellin domain protein K02406 fliC; flagellin
D TOPB45_1630 flagellar hook-associated 2 domain-containing protein K02407 fliD; flagellar hook-associated protein 2
D TOPB45_1629 flagellar protein FliS K02422 fliS; flagellar secretion chaperone FliS
D TOPB45_1538 flagellar motor stator protein MotA K02556 motA; chemotaxis protein MotA
D TOPB45_1539 OmpA/MotB domain protein K02557 motB; chemotaxis protein MotB
D TOPB45_0299 flagellar biosynthesis anti-sigma factor protein FlgM K02398 flgM; negative regulator of flagellin synthesis FlgM
D TOPB45_0797 RNA polymerase, sigma 70 subunit, RpoD subfamily K03086 rpoD; RNA polymerase primary sigma factor
D TOPB45_1032 RNA polymerase, sigma 70 subunit, RpoD subfamily K03086 rpoD; RNA polymerase primary sigma factor
D TOPB45_0054 sigma54 specific transcriptional regulator, Fis family K10941 flrA; sigma-54 dependent transcriptional regulator, flagellar regulatory protein
D TOPB45_1390 RNA polymerase, sigma 54 subunit, RpoN K03092 rpoN; RNA polymerase sigma-54 factor
D TOPB45_1326 RNA polymerase, sigma 28 subunit, FliA/WhiG K02405 fliA; RNA polymerase sigma factor FliA
C 04814 Motor proteins
C 04820 Cytoskeleton in muscle cells [PATH:top04820]
D TOPB45_1027 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01539 ATP1A; sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13]
D TOPB45_0128 Enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
C 04810 Regulation of actin cytoskeleton
#
A09150 Organismal Systems
B
B 09151 Immune system
C 04640 Hematopoietic cell lineage
C 04610 Complement and coagulation cascades
C 04611 Platelet activation
C 04613 Neutrophil extracellular trap formation
C 04620 Toll-like receptor signaling pathway
C 04624 Toll and Imd signaling pathway
C 04621 NOD-like receptor signaling pathway
C 04622 RIG-I-like receptor signaling pathway
C 04623 Cytosolic DNA-sensing pathway
C 04625 C-type lectin receptor signaling pathway
C 04650 Natural killer cell mediated cytotoxicity
C 04612 Antigen processing and presentation
C 04660 T cell receptor signaling pathway
C 04658 Th1 and Th2 cell differentiation
C 04659 Th17 cell differentiation
C 04657 IL-17 signaling pathway
C 04662 B cell receptor signaling pathway
C 04664 Fc epsilon RI signaling pathway
C 04666 Fc gamma R-mediated phagocytosis
C 04670 Leukocyte transendothelial migration
C 04672 Intestinal immune network for IgA production
C 04062 Chemokine signaling pathway
B
B 09152 Endocrine system
C 04911 Insulin secretion
C 04910 Insulin signaling pathway
C 04922 Glucagon signaling pathway
C 04923 Regulation of lipolysis in adipocytes
C 04920 Adipocytokine signaling pathway
C 03320 PPAR signaling pathway
C 04929 GnRH secretion
C 04912 GnRH signaling pathway
C 04913 Ovarian steroidogenesis
C 04915 Estrogen signaling pathway
C 04914 Progesterone-mediated oocyte maturation
C 04917 Prolactin signaling pathway
C 04921 Oxytocin signaling pathway
C 04926 Relaxin signaling pathway
C 04935 Growth hormone synthesis, secretion and action
C 04918 Thyroid hormone synthesis
C 04919 Thyroid hormone signaling pathway
C 04928 Parathyroid hormone synthesis, secretion and action
C 04916 Melanogenesis
C 04924 Renin secretion
C 04614 Renin-angiotensin system
C 04925 Aldosterone synthesis and secretion
C 04927 Cortisol synthesis and secretion
B
B 09153 Circulatory system
C 04260 Cardiac muscle contraction
C 04261 Adrenergic signaling in cardiomyocytes
C 04270 Vascular smooth muscle contraction
B
B 09154 Digestive system
C 04970 Salivary secretion
C 04971 Gastric acid secretion
C 04972 Pancreatic secretion
C 04976 Bile secretion
C 04973 Carbohydrate digestion and absorption
C 04974 Protein digestion and absorption
C 04975 Fat digestion and absorption
C 04979 Cholesterol metabolism
C 04977 Vitamin digestion and absorption
C 04980 Cobalamin transport and metabolism
C 04978 Mineral absorption
B
B 09155 Excretory system
C 04962 Vasopressin-regulated water reabsorption
C 04960 Aldosterone-regulated sodium reabsorption
C 04961 Endocrine and other factor-regulated calcium reabsorption
C 04964 Proximal tubule bicarbonate reclamation
C 04966 Collecting duct acid secretion
B
B 09156 Nervous system
C 04724 Glutamatergic synapse
C 04727 GABAergic synapse
C 04725 Cholinergic synapse
C 04728 Dopaminergic synapse
C 04726 Serotonergic synapse
C 04720 Long-term potentiation
C 04730 Long-term depression
C 04723 Retrograde endocannabinoid signaling
C 04721 Synaptic vesicle cycle
C 04722 Neurotrophin signaling pathway
B
B 09157 Sensory system
C 04744 Phototransduction
C 04745 Phototransduction - fly
C 04740 Olfactory transduction
C 04742 Taste transduction
C 04750 Inflammatory mediator regulation of TRP channels
B
B 09158 Development and regeneration
C 04320 Dorso-ventral axis formation
C 04360 Axon guidance
C 04361 Axon regeneration
C 04380 Osteoclast differentiation
B
B 09149 Aging
C 04211 Longevity regulating pathway
C 04212 Longevity regulating pathway - worm
C 04213 Longevity regulating pathway - multiple species
B
B 09159 Environmental adaptation
C 04710 Circadian rhythm
C 04713 Circadian entrainment
C 04711 Circadian rhythm - fly
C 04712 Circadian rhythm - plant
C 04714 Thermogenesis
C 04626 Plant-pathogen interaction
#
A09160 Human Diseases
B
B 09161 Cancer: overview
C 05200 Pathways in cancer
C 05202 Transcriptional misregulation in cancer
C 05206 MicroRNAs in cancer
C 05205 Proteoglycans in cancer
C 05204 Chemical carcinogenesis - DNA adducts
C 05207 Chemical carcinogenesis - receptor activation
C 05208 Chemical carcinogenesis - reactive oxygen species
C 05203 Viral carcinogenesis
C 05230 Central carbon metabolism in cancer
C 05231 Choline metabolism in cancer
C 05235 PD-L1 expression and PD-1 checkpoint pathway in cancer
B
B 09162 Cancer: specific types
C 05210 Colorectal cancer
C 05212 Pancreatic cancer
C 05225 Hepatocellular carcinoma
C 05226 Gastric cancer
C 05214 Glioma
C 05216 Thyroid cancer
C 05221 Acute myeloid leukemia
C 05220 Chronic myeloid leukemia
C 05217 Basal cell carcinoma
C 05218 Melanoma
C 05211 Renal cell carcinoma
C 05219 Bladder cancer
C 05215 Prostate cancer
C 05213 Endometrial cancer
C 05224 Breast cancer
C 05222 Small cell lung cancer
C 05223 Non-small cell lung cancer
B
B 09172 Infectious disease: viral
C 05166 Human T-cell leukemia virus 1 infection
C 05170 Human immunodeficiency virus 1 infection
C 05161 Hepatitis B
C 05160 Hepatitis C
C 05171 Coronavirus disease - COVID-19
C 05164 Influenza A
C 05162 Measles
C 05168 Herpes simplex virus 1 infection
C 05163 Human cytomegalovirus infection
C 05167 Kaposi sarcoma-associated herpesvirus infection
C 05169 Epstein-Barr virus infection
C 05165 Human papillomavirus infection
B
B 09171 Infectious disease: bacterial
C 05110 Vibrio cholerae infection
C 05120 Epithelial cell signaling in Helicobacter pylori infection
C 05130 Pathogenic Escherichia coli infection
C 05132 Salmonella infection
C 05131 Shigellosis
C 05135 Yersinia infection
C 05133 Pertussis
C 05134 Legionellosis
C 05150 Staphylococcus aureus infection
C 05152 Tuberculosis
C 05100 Bacterial invasion of epithelial cells
B
B 09174 Infectious disease: parasitic
C 05146 Amoebiasis
C 05144 Malaria
C 05145 Toxoplasmosis
C 05140 Leishmaniasis
C 05142 Chagas disease
C 05143 African trypanosomiasis
B
B 09163 Immune disease
C 05310 Asthma
C 05322 Systemic lupus erythematosus
C 05323 Rheumatoid arthritis
C 05320 Autoimmune thyroid disease
C 05321 Inflammatory bowel disease
C 05330 Allograft rejection
C 05332 Graft-versus-host disease
C 05340 Primary immunodeficiency
B
B 09164 Neurodegenerative disease
C 05010 Alzheimer disease
C 05012 Parkinson disease
C 05014 Amyotrophic lateral sclerosis
C 05016 Huntington disease
C 05017 Spinocerebellar ataxia
C 05020 Prion disease
C 05022 Pathways of neurodegeneration - multiple diseases
B
B 09165 Substance dependence
C 05030 Cocaine addiction
C 05031 Amphetamine addiction
C 05032 Morphine addiction
C 05033 Nicotine addiction
C 05034 Alcoholism
B
B 09166 Cardiovascular disease
C 05417 Lipid and atherosclerosis
C 05418 Fluid shear stress and atherosclerosis
C 05410 Hypertrophic cardiomyopathy
C 05412 Arrhythmogenic right ventricular cardiomyopathy
C 05414 Dilated cardiomyopathy
C 05415 Diabetic cardiomyopathy
C 05416 Viral myocarditis
B
B 09167 Endocrine and metabolic disease
C 04930 Type II diabetes mellitus
C 04940 Type I diabetes mellitus
C 04950 Maturity onset diabetes of the young
C 04936 Alcoholic liver disease
C 04932 Non-alcoholic fatty liver disease
C 04931 Insulin resistance
C 04933 AGE-RAGE signaling pathway in diabetic complications
C 04934 Cushing syndrome
B
B 09175 Drug resistance: antimicrobial
C 01501 beta-Lactam resistance [PATH:top01501]
D TOPB45_0574 major facilitator superfamily MFS_1 K08218 ampG; MFS transporter, PAT family, beta-lactamase induction signal transducer AmpG
D TOPB45_0235 Beta-N-acetylhexosaminidase K01207 nagZ; beta-N-acetylhexosaminidase [EC:3.2.1.52]
D TOPB45_0226 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system
D TOPB45_0227 transporter, hydrophobe/amphiphile efflux-1 (HAE1) family K18138 acrB; multidrug efflux pump
D TOPB45_0228 RND efflux system, outer membrane lipoprotein, NodT family K18139 oprM; outer membrane protein, multidrug efflux system
D TOPB45_1071 outer membrane efflux protein K12340 tolC; outer membrane protein
D TOPB45_0239 penicillin-binding protein, 1A family K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4]
D TOPB45_1553 penicillin-binding protein 2 K05515 mrdA; penicillin-binding protein 2 [EC:3.4.16.4]
C 01502 Vancomycin resistance [PATH:top01502]
D TOPB45_1022 D-alanine--D-alanine ligase K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]
D TOPB45_1616 Alanine racemase K01775 alr; alanine racemase [EC:5.1.1.1]
D TOPB45_0940 UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate/D-alanyl-D-alanyl ligase K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10]
D TOPB45_0941 Phospho-N-acetylmuramoyl-pentapeptide-transferase K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]
D TOPB45_0943 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]
C 01503 Cationic antimicrobial peptide (CAMP) resistance [PATH:top01503]
D TOPB45_0428 cell wall hydrolase/autolysin K01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]
D TOPB45_0257 protease Do K04771 degP; serine protease Do [EC:3.4.21.107]
D TOPB45_0226 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system
D TOPB45_0227 transporter, hydrophobe/amphiphile efflux-1 (HAE1) family K18138 acrB; multidrug efflux pump
D TOPB45_1071 outer membrane efflux protein K12340 tolC; outer membrane protein
D TOPB45_0030 Acyl-(acyl-carrier-protein)--UDP-N-acetylglucosamine O-acyltransferase K00677 lpxA; UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129]
B
B 09176 Drug resistance: antineoplastic
C 01521 EGFR tyrosine kinase inhibitor resistance
C 01524 Platinum drug resistance
C 01523 Antifolate resistance
C 01522 Endocrine resistance
#
A09180 Brite Hierarchies
B
B 09181 Protein families: metabolism
C 01000 Enzymes [BR:top01000]
C 01001 Protein kinases [BR:top01001]
D TOPB45_0792 integral membrane sensor signal transduction histidine kinase K13598 ntrY; two-component system, NtrC family, nitrogen regulation sensor histidine kinase NtrY [EC:2.7.13.3]
D TOPB45_1247 integral membrane sensor signal transduction histidine kinase K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
D TOPB45_1469 CheA signal transduction histidine kinase K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C 01009 Protein phosphatases and associated proteins [BR:top01009]
D TOPB45_0621 Adenosylhomocysteinase K01251 AHCY; adenosylhomocysteinase [EC:3.13.2.1]
D TOPB45_1305 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
C 01002 Peptidases and inhibitors [BR:top01002]
D TOPB45_0903 Lipoprotein signal peptidase K03101 lspA; signal peptidase II [EC:3.4.23.36]
D TOPB45_0010 Prepilin peptidase K02654 pilD; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-]
D TOPB45_0466 hydrogenase expression/formation protein K03605 hyaD; hydrogenase maturation protease [EC:3.4.23.-]
D TOPB45_0079 GMP synthase (glutamine-hydrolyzing) K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2]
D TOPB45_0193 NLP/P60 protein K19224 lytE; peptidoglycan DL-endopeptidase LytE [EC:3.4.-.-]
D TOPB45_0560 amidophosphoribosyltransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14]
D TOPB45_1255 Glutamate synthase (ferredoxin) K00265 gltB; glutamate synthase (NADPH) large chain [EC:1.4.1.13]
D TOPB45_1380 Glucosamine--fructose-6-phosphate aminotransferase (isomerizing) K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16]
D TOPB45_0509 hypothetical protein K01953 asnB; asparagine synthase (glutamine-hydrolysing) [EC:6.3.5.4]
D TOPB45_1084 ThiJ/PfpI domain-containing protein K05520 yhbO; deglycase [EC:3.5.1.124]
D TOPB45_0211 ThiJ/PfpI domain-containing protein K05520 yhbO; deglycase [EC:3.5.1.124]
D TOPB45_0264 ErfK/YbiS/YcfS/YnhG family protein K16291 erfK; L,D-transpeptidase ErfK/SrfK
D TOPB45_0409 processing peptidase K07263 pqqL; zinc protease [EC:3.4.24.-]
D TOPB45_0302 peptidase T-like protein K01258 pepT; tripeptide aminopeptidase [EC:3.4.11.4]
D TOPB45_0775 methionine aminopeptidase, type I K01265 map; methionyl aminopeptidase [EC:3.4.11.18]
D TOPB45_0379 peptidase M24 K01262 pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9]
D TOPB45_1364 ATP-dependent metalloprotease FtsH K03798 ftsH; cell division protease FtsH [EC:3.4.24.-]
D TOPB45_1091 AAA ATPase central domain protein K03798 ftsH; cell division protease FtsH [EC:3.4.24.-]
D TOPB45_1051 AAA ATPase central domain protein K03798 ftsH; cell division protease FtsH [EC:3.4.24.-]
D TOPB45_1473 peptidase M48 Ste24p K06013 STE24; STE24 endopeptidase [EC:3.4.24.84]
D TOPB45_1167 protease htpX K03799 htpX; heat shock protein HtpX [EC:3.4.24.-]
D TOPB45_0047 membrane-associated zinc metalloprotease K11749 rseP; regulator of sigma E protease [EC:3.4.24.-]
D TOPB45_1126 peptidase zinc-dependent K06974 amzA; archaemetzincin [EC:3.4.-.-]
D TOPB45_0257 protease Do K04771 degP; serine protease Do [EC:3.4.21.107]
D TOPB45_1498 Serine-type D-Ala-D-Ala carboxypeptidase K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
D TOPB45_0623 beta-lactamase K21469 pbp4b; serine-type D-Ala-D-Ala carboxypeptidase [EC:3.4.16.4]
D TOPB45_0785 ATP-dependent Clp protease proteolytic subunit K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92]
D TOPB45_0787 anti-sigma H sporulation factor, LonB K01338 lon; ATP-dependent Lon protease [EC:3.4.21.53]
D TOPB45_0980 anti-sigma H sporulation factor, LonB K01338 lon; ATP-dependent Lon protease [EC:3.4.21.53]
D TOPB45_1138 signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89]
D TOPB45_1014 carboxyl-terminal protease K03797 E3.4.21.102; carboxyl-terminal processing protease [EC:3.4.21.102]
D TOPB45_0836 signal peptide peptidase SppA, 36K type K04773 sppA; protease IV [EC:3.4.21.-]
D TOPB45_1341 Rhomboid family protein K07059 K07059; rhomboid family protein
D TOPB45_1470 peptidase U61 LD-carboxypeptidase A K01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13]
D TOPB45_0201 ATP-dependent protease hslV K01419 hslV; ATP-dependent HslUV protease, peptidase subunit HslV [EC:3.4.25.2]
D TOPB45_0127 peptidase U62 modulator of DNA gyrase K03592 pmbA; PmbA protein
D TOPB45_0559 peptidase U62 modulator of DNA gyrase K03568 tldD; TldD protein
C 01003 Glycosyltransferases [BR:top01003]
D TOPB45_0857 monofunctional biosynthetic peptidoglycan transglycosylase K03814 mtgA; monofunctional glycosyltransferase [EC:2.4.99.28]
D TOPB45_0239 penicillin-binding protein, 1A family K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4]
D TOPB45_0484 HAD-superfamily hydrolase, subfamily IIB K16055 TPS; trehalose 6-phosphate synthase/phosphatase [EC:2.4.1.15 3.1.3.12]
C 01005 Lipopolysaccharide biosynthesis proteins [BR:top01005]
D TOPB45_0030 Acyl-(acyl-carrier-protein)--UDP-N-acetylglucosamine O-acyltransferase K00677 lpxA; UDP-N-acetylglucosamine acyltransferase [EC:2.3.1.129]
D TOPB45_0027 lipid-A-disaccharide synthase K00748 lpxB; lipid-A-disaccharide synthase [EC:2.4.1.182]
D TOPB45_0263 UDP-3-O-(3-hydroxymyristoyl) N-acetylglucosamine deacetylase K02535 lpxC; UDP-3-O-[3-hydroxymyristoyl] N-acetylglucosamine deacetylase [EC:3.5.1.108]
D TOPB45_0564 UDP-3-O-(3-hydroxymyristoyl) glucosamine N-acyltransferase K02536 lpxD; UDP-3-O-[3-hydroxymyristoyl] glucosamine N-acyltransferase [EC:2.3.1.191]
D TOPB45_0029 protein of unknown function DUF1009 K09949 lpxI; UDP-2,3-diacylglucosamine hydrolase [EC:3.6.1.54]
D TOPB45_1452 Tetraacyldisaccharide 4'-kinase K00912 lpxK; tetraacyldisaccharide 4'-kinase [EC:2.7.1.130]
D TOPB45_1147 Three-deoxy-D-manno-octulosonic-acid transferase domain-containing protein K02527 kdtA; 3-deoxy-D-manno-octulosonic-acid transferase [EC:2.4.99.12 2.4.99.13 2.4.99.14 2.4.99.15]
D TOPB45_0477 2-dehydro-3-deoxyphosphooctonate aldolase K01627 kdsA; 2-dehydro-3-deoxyphosphooctonate aldolase (KDO 8-P synthase) [EC:2.5.1.55]
D TOPB45_1080 3-deoxy-manno-octulosonate cytidylyltransferase K00979 kdsB; 3-deoxy-manno-octulosonate cytidylyltransferase (CMP-KDO synthetase) [EC:2.7.7.38]
D TOPB45_0476 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase, YrbI family K03270 kdsC; 3-deoxy-D-manno-octulosonate 8-phosphate phosphatase (KDO 8-P phosphatase) [EC:3.1.3.45]
D TOPB45_0196 KpsF/GutQ family protein K06041 kdsD; arabinose-5-phosphate isomerase [EC:5.3.1.13]
D TOPB45_0129 PfkB domain protein K21344 rfaE1; D-glycero-beta-D-manno-heptose-7-phosphate kinase [EC:2.7.1.167]
D TOPB45_0300 rfaE bifunctional protein K21345 rfaE2; D-glycero-beta-D-manno-heptose 1-phosphate adenylyltransferase [EC:2.7.7.70]
D TOPB45_1165 lipopolysaccharide heptosyltransferase I K02841 waaC; lipopolysaccharide heptosyltransferase I [EC:2.4.99.23]
D TOPB45_0124 lipopolysaccharide heptosyltransferase II K02843 waaF; lipopolysaccharide heptosyltransferase II [EC:2.4.99.24]
D TOPB45_0511 O-antigen polymerase K02847 waaL; O-antigen ligase [EC:2.4.99.26]
D TOPB45_0822 Phosphoheptose isomerase K03271 gmhA; D-sedoheptulose 7-phosphate isomerase [EC:5.3.1.28]
D TOPB45_1164 histidinol-phosphate phosphatase family protein K03273 gmhB; D-glycero-D-manno-heptose 1,7-bisphosphate phosphatase [EC:3.1.3.82 3.1.3.83]
D TOPB45_1460 ADP-L-glycero-D-manno-heptose-6-epimerase K03274 gmhD; ADP-L-glycero-D-manno-heptose 6-epimerase [EC:5.1.3.20]
D TOPB45_0341 glycosyl transferase family 2 K12990 rfbF; rhamnosyltransferase [EC:2.4.1.-]
C 01011 Peptidoglycan biosynthesis and degradation proteins [BR:top01011]
D TOPB45_0844 UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7]
D TOPB45_0945 UDP-N-acetylenolpyruvoylglucosamine reductase K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98]
D TOPB45_0944 UDP-N-acetylmuramate--L-alanine ligase K01924 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8]
D TOPB45_0942 UDP-N-acetylmuramoylalanine--D-glutamate ligase K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9]
D TOPB45_0939 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase K01928 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--2,6-diaminopimelate ligase [EC:6.3.2.13]
D TOPB45_1022 D-alanine--D-alanine ligase K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4]
D TOPB45_1616 Alanine racemase K01775 alr; alanine racemase [EC:5.1.1.1]
D TOPB45_0137 Glutamate racemase K01776 murI; glutamate racemase [EC:5.1.1.3]
D TOPB45_1470 peptidase U61 LD-carboxypeptidase A K01297 ldcA; muramoyltetrapeptide carboxypeptidase [EC:3.4.17.13]
D TOPB45_0941 Phospho-N-acetylmuramoyl-pentapeptide-transferase K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13]
D TOPB45_0943 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227]
D TOPB45_0841 Undecaprenyl-diphosphatase K06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27]
D TOPB45_0959 integral membrane protein MviN K03980 murJ; putative peptidoglycan lipid II flippase
D TOPB45_0328 virulence factor MVIN family protein K03980 murJ; putative peptidoglycan lipid II flippase
D TOPB45_0239 penicillin-binding protein, 1A family K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4]
D TOPB45_1553 penicillin-binding protein 2 K05515 mrdA; penicillin-binding protein 2 [EC:3.4.16.4]
D TOPB45_1498 Serine-type D-Ala-D-Ala carboxypeptidase K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4]
D TOPB45_0623 beta-lactamase K21469 pbp4b; serine-type D-Ala-D-Ala carboxypeptidase [EC:3.4.16.4]
D TOPB45_0857 monofunctional biosynthetic peptidoglycan transglycosylase K03814 mtgA; monofunctional glycosyltransferase [EC:2.4.99.28]
D TOPB45_0264 ErfK/YbiS/YcfS/YnhG family protein K16291 erfK; L,D-transpeptidase ErfK/SrfK
D TOPB45_0193 NLP/P60 protein K19224 lytE; peptidoglycan DL-endopeptidase LytE [EC:3.4.-.-]
D TOPB45_1587 Membrane-bound lytic murein transglycosylase B K08305 mltB; peptidoglycan lytic transglycosylase B [EC:4.2.2.29]
D TOPB45_1004 Lytic transglycosylase catalytic K08307 mltD; peptidoglycan lytic transglycosylase D [EC:4.2.2.29]
D TOPB45_0654 aminodeoxychorismate lyase K07082 mltG; peptidoglycan lytic transglycosylase G [EC:4.2.2.29]
D TOPB45_0296 rare lipoprotein A K03642 rlpA; peptidoglycan lytic transglycosylase [EC:4.2.2.29]
D TOPB45_0428 cell wall hydrolase/autolysin K01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]
C 01004 Lipid biosynthesis proteins [BR:top01004]
D TOPB45_0674 malonyl CoA-acyl carrier protein transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]
D TOPB45_0085 3-oxoacyl-(acyl-carrier-protein) synthase 3 K00648 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180]
D TOPB45_0015 3-oxoacyl-(acyl-carrier-protein) synthase 2 K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]
D TOPB45_1299 Beta-ketoacyl-acyl-carrier-protein synthase II K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179]
D TOPB45_1597 3-oxoacyl-(acyl-carrier-protein) reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
D TOPB45_0031 (3R)-hydroxymyristoyl-(acyl-carrier-protein) dehydratase K02372 fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59]
D TOPB45_0636 Acetate--CoA ligase K01895 ACSS1_2; acetyl-CoA synthetase [EC:6.2.1.1]
D TOPB45_0633 acetyl coenzyme A synthetase (ADP forming), alpha domain protein K24012 acdAB; acetate---CoA ligase (ADP-forming) [EC:6.2.1.13]
D TOPB45_1300 o-succinylbenzoate--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
D TOPB45_0084 Phosphate acyltransferase K03621 plsX; phosphate acyltransferase [EC:2.3.1.274]
D TOPB45_1360 Glycerol-3-phosphate acyltransferase K08591 plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275]
D TOPB45_0373 1-acyl-sn-glycerol-3-phosphate acyltransferase K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]
C 01008 Polyketide biosynthesis proteins
C 01006 Prenyltransferases [BR:top01006]
D TOPB45_1415 Farnesyltranstransferase K13789 GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29]
D TOPB45_0180 Trans-hexaprenyltranstransferase K02523 ispB; octaprenyl-diphosphate synthase [EC:2.5.1.90]
D TOPB45_1019 Undecaprenyl pyrophosphate synthase K00806 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31]
D TOPB45_0219 tRNA dimethylallyltransferase K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]
D TOPB45_0221 4-hydroxybenzoate polyprenyltransferase K03179 ubiA; 4-hydroxybenzoate polyprenyltransferase [EC:2.5.1.39]
C 01007 Amino acid related enzymes [BR:top01007]
D TOPB45_1082 glutamyl-tRNA synthetase K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D TOPB45_1455 Tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D TOPB45_1131 tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D TOPB45_0721 cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D TOPB45_0265 cysteine synthase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D TOPB45_1528 Arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D TOPB45_1186 Methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D TOPB45_0902 Isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D TOPB45_1037 Valyl-tRNA synthetase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D TOPB45_1433 leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D TOPB45_1576 Lysyl-tRNA synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D TOPB45_1293 aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D TOPB45_0376 Histidyl-tRNA synthetase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D TOPB45_1283 Glycyl-tRNA synthetase alpha subunit K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]
D TOPB45_1284 Glycyl-tRNA synthetase beta subunit K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]
D TOPB45_1626 Seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D TOPB45_0563 Prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
D TOPB45_0688 threonyl-tRNA synthetase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D TOPB45_0619 alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D TOPB45_0545 Phenylalanyl-tRNA synthetase alpha chain K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D TOPB45_0544 Phenylalanyl-tRNA synthetase beta chain K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D TOPB45_0681 Aspartate transaminase K00812 aspB; aspartate aminotransferase [EC:2.6.1.1]
D TOPB45_1216 Aspartate transaminase K11358 yhdR; aspartate aminotransferase [EC:2.6.1.1]
D TOPB45_1561 tyrosine/nicotianamine aminotransferase K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2]
D TOPB45_0370 LL-diaminopimelate aminotransferase K10206 E2.6.1.83; LL-diaminopimelate aminotransferase [EC:2.6.1.83]
D TOPB45_1156 Histidinol-phosphate aminotransferase K00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]
D TOPB45_0138 Acetylornithine/succinyldiaminopimelate aminotransferase K00821 argD; acetylornithine/N-succinyldiaminopimelate aminotransferase [EC:2.6.1.11 2.6.1.17]
D TOPB45_0662 Glutamate-1-semialdehyde 2,1-aminomutase K01845 hemL; glutamate-1-semialdehyde 2,1-aminomutase [EC:5.4.3.8]
D TOPB45_0503 branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42]
D TOPB45_1002 DegT/DnrJ/EryC1/StrS aminotransferase K13017 wbpE; UDP-2-acetamido-2-deoxy-ribo-hexuluronate aminotransferase [EC:2.6.1.98]
C 00199 Cytochrome P450
C 00194 Photosynthesis proteins [BR:top00194]
D TOPB45_1545 ATP synthase epsilon chain K02114 ATPF1E; F-type H+-transporting ATPase subunit epsilon
D TOPB45_1546 ATP synthase subunit beta K02112 ATPF1B; F-type H+/Na+-transporting ATPase subunit beta [EC:7.1.2.2 7.2.2.1]
D TOPB45_1547 ATP synthase gamma chain K02115 ATPF1G; F-type H+-transporting ATPase subunit gamma
D TOPB45_1548 ATP synthase subunit alpha K02111 ATPF1A; F-type H+/Na+-transporting ATPase subunit alpha [EC:7.1.2.2 7.2.2.1]
D TOPB45_1549 ATP synthase subunit delta K02113 ATPF1D; F-type H+-transporting ATPase subunit delta
D TOPB45_1550 ATP synthase subunit b K02109 ATPF0B; F-type H+-transporting ATPase subunit b
D TOPB45_1551 H+transporting two-sector ATPase B/B' subunit K02109 ATPF0B; F-type H+-transporting ATPase subunit b
D TOPB45_0880 ATP synthase subunit c K02110 ATPF0C; F-type H+-transporting ATPase subunit c
D TOPB45_0879 ATP synthase subunit a K02108 ATPF0A; F-type H+-transporting ATPase subunit a
D TOPB45_0877 hypothetical protein K02116 atpI; ATP synthase protein I
B
B 09182 Protein families: genetic information processing
C 03000 Transcription factors [BR:top03000]
D TOPB45_0908 transcriptional regulator, LuxR family K20918 vpsT; LuxR family transcriptional regulator, positive regulator of biofilm formation
D TOPB45_0522 ferric uptake regulator, Fur family K03711 fur; Fur family transcriptional regulator, ferric uptake regulator
D TOPB45_1606 ferric uptake regulator, Fur family K09825 perR; Fur family transcriptional regulator, peroxide stress response regulator
D TOPB45_1625 transcriptional regulator, BadM/Rrf2 family K13643 iscR; Rrf2 family transcriptional regulator, iron-sulfur cluster assembly transcription factor
D TOPB45_0888 regulatory protein ArsR K03892 arsR; ArsR family transcriptional regulator, arsenate/arsenite/antimonite-responsive transcriptional repressor
D TOPB45_0470 biotin/acetyl-CoA-carboxylase ligase K03524 birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]
D TOPB45_1275 biotin/acetyl-CoA-carboxylase ligase K03524 birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15]
D TOPB45_0054 sigma54 specific transcriptional regulator, Fis family K10941 flrA; sigma-54 dependent transcriptional regulator, flagellar regulatory protein
D TOPB45_1258 transcriptional regulator, NifA, Fis Family K02584 nifA; Nif-specific regulatory protein
D TOPB45_0934 putative transcriptional regulator, ModE family K02019 modE; molybdate transport system regulatory protein
D TOPB45_1519 Redox-sensing transcriptional repressor rex K01926 rex; redox-sensing transcriptional repressor
D TOPB45_1153 transcriptional regulator NikR, CopG family K07722 nikR; CopG family transcriptional regulator, nickel-responsive regulator
D TOPB45_0598 parB-like partition protein K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein
D TOPB45_0949 ParB domain protein nuclease K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein
D TOPB45_1044 ParB domain protein nuclease K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein
D TOPB45_0285 Bifunctional protein pyrR K02825 pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9]
D TOPB45_0041 transcriptional regulator, TraR/DksA family K06204 dksA; RNA polymerase-binding transcription factor
D TOPB45_1196 Transcriptional repressor nrdR K07738 nrdR; transcriptional repressor NrdR
D TOPB45_0935 Protein mraZ K03925 mraZ; transcriptional regulator MraZ
C 03021 Transcription machinery [BR:top03021]
D TOPB45_0781 DNA-directed RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
D TOPB45_0164 DNA-directed RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
D TOPB45_0163 DNA-directed RNA polymerase subunit beta' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
D TOPB45_0038 DNA-directed RNA polymerase subunit omega K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
D TOPB45_0797 RNA polymerase, sigma 70 subunit, RpoD subfamily K03086 rpoD; RNA polymerase primary sigma factor
D TOPB45_1032 RNA polymerase, sigma 70 subunit, RpoD subfamily K03086 rpoD; RNA polymerase primary sigma factor
D TOPB45_1348 putative RNA polymerase, sigma 70 family subunit K03089 rpoH; RNA polymerase sigma-32 factor
D TOPB45_1390 RNA polymerase, sigma 54 subunit, RpoN K03092 rpoN; RNA polymerase sigma-54 factor
D TOPB45_1326 RNA polymerase, sigma 28 subunit, FliA/WhiG K02405 fliA; RNA polymerase sigma factor FliA
D TOPB45_1478 NusA antitermination factor K02600 nusA; transcription termination/antitermination protein NusA
D TOPB45_1383 NusB antitermination factor K03625 nusB; transcription antitermination protein NusB
D TOPB45_0169 NusG antitermination factor K02601 nusG; transcription termination/antitermination protein NusG
D TOPB45_0041 transcriptional regulator, TraR/DksA family K06204 dksA; RNA polymerase-binding transcription factor
D TOPB45_0025 transcription elongation factor GreA K03624 greA; transcription elongation factor GreA
D TOPB45_0788 transcription termination factor Rho K03628 rho; transcription termination factor Rho
C 03019 Messenger RNA biogenesis [BR:top03019]
D TOPB45_1163 ribonuclease, Rne/Rng family K08301 rng; ribonuclease G [EC:3.1.26.-]
D TOPB45_0297 Ribonuclease 3 K03685 rnc; ribonuclease III [EC:3.1.26.3]
D TOPB45_1594 2,3 cyclic-nucleotide 2-phosphodiesterase K18682 rny; ribonucrease Y [EC:3.1.-.-]
D TOPB45_1154 ribonuclease R K12573 rnr; ribonuclease R [EC:3.1.13.1]
D TOPB45_0128 Enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
D TOPB45_1161 Polyribonucleotide nucleotidyltransferase K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]
D TOPB45_0788 transcription termination factor Rho K03628 rho; transcription termination factor Rho
D TOPB45_1305 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11]
D TOPB45_1533 Chaperone protein dnaK K04043 dnaK; molecular chaperone DnaK
D TOPB45_1393 60 kDa chaperonin K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D TOPB45_0783 polynucleotide adenylyltransferase/metal dependent phosphohydrolase K00970 pcnB; poly(A) polymerase [EC:2.7.7.19]
D TOPB45_1388 UPF0042 nucleotide-binding protein yhbJ K06958 rapZ; RNase adapter protein RapZ
C 03041 Spliceosome
C 03011 Ribosome [BR:top03011]
D TOPB45_0835 RNA binding S1 domain protein K02945 RP-S1; small subunit ribosomal protein S1
D TOPB45_1015 ribosomal protein S2 K02967 RP-S2; small subunit ribosomal protein S2
D TOPB45_0759 ribosomal protein S3 K02982 RP-S3; small subunit ribosomal protein S3
D TOPB45_0780 ribosomal protein S4 K02986 RP-S4; small subunit ribosomal protein S4
D TOPB45_0770 ribosomal protein S5 K02988 RP-S5; small subunit ribosomal protein S5
D TOPB45_0190 30S ribosomal protein S6 K02990 RP-S6; small subunit ribosomal protein S6
D TOPB45_0749 ribosomal protein S7 K02992 RP-S7; small subunit ribosomal protein S7
D TOPB45_0767 ribosomal protein S8 K02994 RP-S8; small subunit ribosomal protein S8
D TOPB45_0716 ribosomal protein S9 K02996 RP-S9; small subunit ribosomal protein S9
D TOPB45_0752 30S ribosomal protein S10 K02946 RP-S10; small subunit ribosomal protein S10
D TOPB45_0779 30S ribosomal protein S11 K02948 RP-S11; small subunit ribosomal protein S11
D TOPB45_0748 ribosomal protein S12 K02950 RP-S12; small subunit ribosomal protein S12
D TOPB45_0778 30S ribosomal protein S13 K02952 RP-S13; small subunit ribosomal protein S13
D TOPB45_0766 ribosomal protein S14 K02954 RP-S14; small subunit ribosomal protein S14
D TOPB45_0162 ribosomal protein S15 K02956 RP-S15; small subunit ribosomal protein S15
D TOPB45_0706 30S ribosomal protein S16 K02959 RP-S16; small subunit ribosomal protein S16
D TOPB45_0762 30S ribosomal protein S17 K02961 RP-S17; small subunit ribosomal protein S17
D TOPB45_0189 30S ribosomal protein S18 K02963 RP-S18; small subunit ribosomal protein S18
D TOPB45_0757 ribosomal protein S19 K02965 RP-S19; small subunit ribosomal protein S19
D TOPB45_1442 30S ribosomal protein S20 K02968 RP-S20; small subunit ribosomal protein S20
D TOPB45_0794 30S ribosomal protein S21 K02970 RP-S21; small subunit ribosomal protein S21
D TOPB45_0167 ribosomal protein L1 K02863 RP-L1; large subunit ribosomal protein L1
D TOPB45_0756 ribosomal protein L2 K02886 RP-L2; large subunit ribosomal protein L2
D TOPB45_0753 50S ribosomal protein L3 K02906 RP-L3; large subunit ribosomal protein L3
D TOPB45_0754 ribosomal protein L4/L1e K02926 RP-L4; large subunit ribosomal protein L4
D TOPB45_0765 ribosomal protein L5 K02931 RP-L5; large subunit ribosomal protein L5
D TOPB45_0768 ribosomal protein L6 K02933 RP-L6; large subunit ribosomal protein L6
D TOPB45_0188 50S ribosomal protein L9 K02939 RP-L9; large subunit ribosomal protein L9
D TOPB45_0166 50S ribosomal protein L10 K02864 RP-L10; large subunit ribosomal protein L10
D TOPB45_0168 ribosomal protein L11 K02867 RP-L11; large subunit ribosomal protein L11
D TOPB45_0165 50S ribosomal protein L7/L12 K02935 RP-L7; large subunit ribosomal protein L7/L12
D TOPB45_0715 ribosomal protein L13 K02871 RP-L13; large subunit ribosomal protein L13
D TOPB45_0763 ribosomal protein L14 K02874 RP-L14; large subunit ribosomal protein L14
D TOPB45_0772 ribosomal protein L15 K02876 RP-L15; large subunit ribosomal protein L15
D TOPB45_0760 50S ribosomal protein L16 K02878 RP-L16; large subunit ribosomal protein L16
D TOPB45_0782 50S ribosomal protein L17 K02879 RP-L17; large subunit ribosomal protein L17
D TOPB45_0769 ribosomal protein L18 K02881 RP-L18; large subunit ribosomal protein L18
D TOPB45_0981 50S ribosomal protein L19 K02884 RP-L19; large subunit ribosomal protein L19
D TOPB45_0546 50S ribosomal protein L20 K02887 RP-L20; large subunit ribosomal protein L20
D TOPB45_1358 50S ribosomal protein L21 K02888 RP-L21; large subunit ribosomal protein L21
D TOPB45_0758 ribosomal protein L22 K02890 RP-L22; large subunit ribosomal protein L22
D TOPB45_0755 Ribosomal protein L25/L23 K02892 RP-L23; large subunit ribosomal protein L23
D TOPB45_0764 ribosomal protein L24 K02895 RP-L24; large subunit ribosomal protein L24
D TOPB45_1359 50S ribosomal protein L27 K02899 RP-L27; large subunit ribosomal protein L27
D TOPB45_1412 50S ribosomal protein L28 K02902 RP-L28; large subunit ribosomal protein L28
D TOPB45_0761 ribosomal protein L29 K02904 RP-L29; large subunit ribosomal protein L29
D TOPB45_0771 ribosomal protein L30 K02907 RP-L30; large subunit ribosomal protein L30
D TOPB45_0253 50S ribosomal protein L31 K02909 RP-L31; large subunit ribosomal protein L31
D TOPB45_0083 50S ribosomal protein L32 K02911 RP-L32; large subunit ribosomal protein L32
D TOPB45_0171 50S ribosomal protein L33 K02913 RP-L33; large subunit ribosomal protein L33
D TOPB45_0587 50S ribosomal protein L34 K02914 RP-L34; large subunit ribosomal protein L34
D TOPB45_0547 50S ribosomal protein L35 K02916 RP-L35; large subunit ribosomal protein L35
D TOPB45_0777 50S ribosomal protein L36 K02919 RP-L36; large subunit ribosomal protein L36
D TOPB45_0076 50S ribosomal protein L25 K02897 RP-L25; large subunit ribosomal protein L25
D TOPB45_R0008 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA
D TOPB45_R0012 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D TOPB45_R0009 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
C 03009 Ribosome biogenesis [BR:top03009]
D TOPB45_0297 Ribonuclease 3 K03685 rnc; ribonuclease III [EC:3.1.26.3]
D TOPB45_0298 GTP-binding protein Era-like-protein K03595 era; GTPase
D TOPB45_0431 GTPase obg K03979 obgE; GTPase [EC:3.6.5.-]
D TOPB45_0041 transcriptional regulator, TraR/DksA family K06204 dksA; RNA polymerase-binding transcription factor
D TOPB45_1478 NusA antitermination factor K02600 nusA; transcription termination/antitermination protein NusA
D TOPB45_1383 NusB antitermination factor K03625 nusB; transcription antitermination protein NusB
D TOPB45_0169 NusG antitermination factor K02601 nusG; transcription termination/antitermination protein NusG
D TOPB45_1123 pseudouridine synthase Rsu K06183 rsuA; 16S rRNA pseudouridine516 synthase [EC:5.4.99.19]
D TOPB45_0655 Ribosomal RNA small subunit methyltransferase A K02528 ksgA; 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182]
D TOPB45_0308 sun protein K03500 rsmB; 16S rRNA (cytosine967-C5)-methyltransferase [EC:2.1.1.176]
D TOPB45_0232 methyltransferase K08316 rsmD; 16S rRNA (guanine966-N2)-methyltransferase [EC:2.1.1.171]
D TOPB45_0183 Ribosomal RNA small subunit methyltransferase E K09761 rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193]
D TOPB45_0936 Ribosomal RNA small subunit methyltransferase H K03438 mraW; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199]
D TOPB45_0388 Ribosomal RNA small subunit methyltransferase I K07056 rsmI; 16S rRNA (cytidine1402-2'-O)-methyltransferase [EC:2.1.1.198]
D TOPB45_1173 RNA methyltransferase, TrmH family, group 3 K03218 rlmB; 23S rRNA (guanosine2251-2'-O)-methyltransferase [EC:2.1.1.185]
D TOPB45_1376 tRNA/rRNA methyltransferase (SpoU) K03218 rlmB; 23S rRNA (guanosine2251-2'-O)-methyltransferase [EC:2.1.1.185]
D TOPB45_0131 Ribosomal RNA large subunit methyltransferase E K02427 rlmE; 23S rRNA (uridine2552-2'-O)-methyltransferase [EC:2.1.1.166]
D TOPB45_0436 Ribosomal RNA large subunit methyltransferase H K00783 rlmH; 23S rRNA (pseudouridine1915-N3)-methyltransferase [EC:2.1.1.177]
D TOPB45_1371 hypothetical protein K06969 rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191]
D TOPB45_0022 Ribosomal RNA large subunit methyltransferase N K06941 rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192]
D TOPB45_0875 deoxyribonuclease/rho motif-related TRAM K03215 rumA; 23S rRNA (uracil1939-C5)-methyltransferase [EC:2.1.1.190]
D TOPB45_1145 pseudouridine synthase Rsu K06178 rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22]
D TOPB45_1530 pseudouridine synthase K06180 rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23]
D TOPB45_0159 pseudouridine synthase, RluA family K06180 rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23]
D TOPB45_1387 ribosomal-protein-alanine acetyltransferase K03789 rimI; [ribosomal protein S18]-alanine N-acetyltransferase [EC:2.3.1.266]
D TOPB45_0447 RimK domain protein ATP-grasp K05844 rimK; ribosomal protein S6--L-glutamate ligase [EC:6.3.2.-]
D TOPB45_0516 RimK domain protein ATP-grasp K05844 rimK; ribosomal protein S6--L-glutamate ligase [EC:6.3.2.-]
D TOPB45_0708 Ribosome maturation factor rimM K02860 rimM; 16S rRNA processing protein RimM
D TOPB45_0203 Ribosomal protein S12 methylthiotransferase rimO K14441 rimO; ribosomal protein S12 methylthiotransferase [EC:2.8.4.4]
D TOPB45_1515 YcaO-domain protein K09136 ycaO; ribosomal protein S12 methylthiotransferase accessory factor
D TOPB45_1523 YcaO-domain protein K09136 ycaO; ribosomal protein S12 methylthiotransferase accessory factor
D TOPB45_0573 Ribosomal protein L11 methyltransferase K02687 prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-]
D TOPB45_1472 Methyltransferase type 11 K02687 prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-]
D TOPB45_1163 ribonuclease, Rne/Rng family K08301 rng; ribonuclease G [EC:3.1.26.-]
D TOPB45_1540 GTP-binding protein engA K03977 engA; GTPase
D TOPB45_1377 GTP-binding proten HflX K03665 hflX; GTPase
D TOPB45_1609 Sua5/YciO/YrdC/YwlC family protein K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
D TOPB45_1413 (p)ppGpp synthetase I, SpoT/RelA K01139 spoT; GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2]
D TOPB45_1077 Ribosome-binding factor A K02834 rbfA; ribosome-binding factor A
D TOPB45_1479 Ribosome maturation factor rimP K09748 rimP; ribosome maturation factor RimP
D TOPB45_1378 iojap-like protein K09710 ybeB; ribosome-associated protein
D TOPB45_1389 sigma 54 modulation protein/ribosomal protein S30EA K05808 hpf; ribosome hibernation promoting factor
D TOPB45_0283 GTP-binding protein YchF K06942 ychF; ribosome-binding ATPase
D TOPB45_0082 protein of unknown function DUF177 K07040 yceD; DUF177 domain-containing protein
C 03016 Transfer RNA biogenesis [BR:top03016]
D TOPB45_0834 Polynucleotide adenylyltransferase region K00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]
D TOPB45_0200 protein of unknown function UPF0027 K14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
D TOPB45_1541 protein of unknown function DUF101 K24956 ZBTB8OS; protein archease
D TOPB45_1082 glutamyl-tRNA synthetase K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D TOPB45_0563 Prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
D TOPB45_0902 Isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D TOPB45_1433 leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D TOPB45_1186 Methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D TOPB45_1528 Arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D TOPB45_1576 Lysyl-tRNA synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D TOPB45_1293 aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D TOPB45_0619 alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D TOPB45_0688 threonyl-tRNA synthetase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D TOPB45_1626 Seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D TOPB45_0721 cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D TOPB45_0265 cysteine synthase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D TOPB45_1037 Valyl-tRNA synthetase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D TOPB45_0376 Histidyl-tRNA synthetase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D TOPB45_0545 Phenylalanyl-tRNA synthetase alpha chain K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D TOPB45_0544 Phenylalanyl-tRNA synthetase beta chain K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D TOPB45_1455 Tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D TOPB45_1131 tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D TOPB45_0669 D-tyrosyl-tRNA(Tyr) deacylase K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D TOPB45_1185 histidine triad (HIT) protein K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]
D TOPB45_1439 protein-L-isoaspartate(D-aspartate) O-methyltransferase K07442 TRM61; tRNA (adenine57-N1/adenine58-N1)-methyltransferase catalytic subunit [EC:2.1.1.219 2.1.1.220]
D TOPB45_1249 Uncharacterized protein family UPF0066 K22900 TRMO; tRNA (adenine37-N6)-methyltransferase [EC:2.1.1.-]
D TOPB45_0718 tRNA pseudouridine synthase A K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]
D TOPB45_1075 tRNA pseudouridine synthase B K03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]
D TOPB45_0123 tRNA pseudouridine synthase D TruD K06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]
D TOPB45_0236 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D TOPB45_1609 Sua5/YciO/YrdC/YwlC family protein K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
D TOPB45_0219 tRNA dimethylallyltransferase K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]
D TOPB45_0592 tRNA modification GTPase mnmE K03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]
D TOPB45_1029 tRNA uridine 5-carboxymethylaminomethyl modification enzyme mnmG K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme
D TOPB45_1445 Selenide, water dikinase K01008 selD; selenide, water dikinase [EC:2.7.9.3]
D TOPB45_0588 Ribonuclease P protein component K03536 rnpA; ribonuclease P protein component [EC:3.1.26.5]
D TOPB45_R0026 rnpB; RNA component of RNaseP K01978 rnpB; M1 RNA
D TOPB45_1431 UPF0278 protein K09006 K09006; RNA-free ribonuclease P [EC:3.1.26.5]
D TOPB45_1150 Ribonuclease PH K00989 rph; ribonuclease PH [EC:2.7.7.56]
D TOPB45_0630 ribonuclease II K01147 rnb; exoribonuclease II [EC:3.1.13.1]
D TOPB45_0605 2'-5' RNA ligase K01975 thpR; RNA 2',3'-cyclic 3'-phosphodiesterase [EC:3.1.4.58]
D TOPB45_1031 hypothetical protein K07559 kptA; putative RNA 2'-phosphotransferase [EC:2.7.1.-]
D TOPB45_1283 Glycyl-tRNA synthetase alpha subunit K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]
D TOPB45_1284 Glycyl-tRNA synthetase beta subunit K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]
D TOPB45_0472 CMP/dCMP deaminase zinc-binding protein K11991 tadA; tRNA(adenine34) deaminase [EC:3.5.4.33]
D TOPB45_0973 (Dimethylallyl)adenosine tRNA methylthiotransferase miaB K06168 miaB; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]
D TOPB45_0517 MiaB-like tRNA modifying enzyme K18707 mtaB; threonylcarbamoyladenosine tRNA methylthiotransferase MtaB [EC:2.8.4.5]
D TOPB45_0874 RNA methyltransferase, TrmH family, group 1 K02533 lasT; tRNA/rRNA methyltransferase [EC:2.1.1.-]
D TOPB45_1213 Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase trmFO K04094 trmFO; methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74]
D TOPB45_0709 tRNA (guanine-N(1)-)-methyltransferase K00554 trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]
D TOPB45_0020 Methyltransferase type 11 K15460 yfiC; tRNA1Val (adenine37-N6)-methyltransferase [EC:2.1.1.223]
D TOPB45_1270 RNA methylase, NOL1/NOP2/sun family K22446 K22446; tRNA (cytosine49-C5)-methyltransferase [EC:2.1.1.-]
D TOPB45_1516 tRNA-specific 2-thiouridylase mnmA K00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]
D TOPB45_0929 tRNA methyl transferase K00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]
D TOPB45_1141 protein of unknown function UPF0021 K21947 ttuA; tRNA-5-methyluridine54 2-sulfurtransferase [EC:2.8.1.15]
D TOPB45_0003 PP-loop domain protein K14058 ttcA; tRNA 2-thiocytidine biosynthesis protein TtcA
D TOPB45_1240 SirA-like domain-containing protein K04085 tusA; tRNA 2-thiouridine synthesizing protein A [EC:2.8.1.-]
D TOPB45_0698 S-adenosylmethionine:tRNA ribosyltransferase-isomerase K07568 queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17]
D TOPB45_1604 exsB protein K06920 queC; 7-cyano-7-deazaguanine synthase [EC:6.3.4.20]
D TOPB45_1346 queuosine biosynthesis protein QueD K01737 queD; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]
D TOPB45_1347 Radical SAM domain protein K10026 queE; 7-carboxy-7-deazaguanine synthase [EC:4.3.99.3]
D TOPB45_1307 NADPH-dependent 7-cyano-7-deazaguanine reductase K09457 queF; 7-cyano-7-deazaguanine reductase [EC:1.7.1.13]
D TOPB45_0519 protein of unknown function DUF208 K09765 queH; epoxyqueuosine reductase [EC:1.17.99.6]
D TOPB45_1215 Queuine tRNA-ribosyltransferase K00773 tgt; queuine tRNA-ribosyltransferase [EC:2.4.2.29]
D TOPB45_1363 tRNA(Ile)-lysidine synthase K04075 tilS; tRNA(Ile)-lysidine synthase [EC:6.3.4.19]
D TOPB45_0048 universal protein YeaZ K14742 tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB
D TOPB45_0823 O-sialoglycoprotein endopeptidase K25706 tsaD; tRNA N6-adenosine threonylcarbamoyltransferase [EC:2.3.1.234]
D TOPB45_0410 Uncharacterized protein family UPF0079, ATPase K06925 tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
D TOPB45_1154 ribonuclease R K12573 rnr; ribonuclease R [EC:3.1.13.1]
D TOPB45_1161 Polyribonucleotide nucleotidyltransferase K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]
C 03012 Translation factors [BR:top03012]
D TOPB45_1079 translation initiation factor IF-2 K02519 infB; translation initiation factor IF-2
D TOPB45_0689 Translation initiation factor IF-3 K02520 infC; translation initiation factor IF-3
D TOPB45_1016 Elongation factor Ts K02357 tsf; elongation factor Ts
D TOPB45_0172 translation elongation factor Tu K02358 tuf; elongation factor Tu
D TOPB45_0751 translation elongation factor Tu K02358 tuf; elongation factor Tu
D TOPB45_1443 small GTP-binding protein K02355 fusA; elongation factor G
D TOPB45_0750 translation elongation factor G K02355 fusA; elongation factor G
D TOPB45_1285 selenocysteine-specific translation elongation factor K03833 selB; selenocysteine-specific elongation factor
D TOPB45_0252 Peptide chain release factor 1 K02835 prfA; peptide chain release factor 1
D TOPB45_1018 Ribosome-recycling factor K02838 frr; ribosome recycling factor
D TOPB45_0843 protein-(glutamine-N5) methyltransferase, release factor-specific K02493 hemK; release factor glutamine methyltransferase [EC:2.1.1.297]
D TOPB45_0077 Peptidyl-tRNA hydrolase K01056 PTH1; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29]
D TOPB45_0776 Translation initiation factor IF-1 K02518 infA; translation initiation factor IF-1
D TOPB45_1192 Elongation factor P K02356 efp; elongation factor P
D TOPB45_0534 hypothetical protein K02836 prfB; peptide chain release factor 2
C 03110 Chaperones and folding catalysts [BR:top03110]
D TOPB45_1008 ATP-dependent chaperone ClpB K03695 clpB; ATP-dependent Clp protease ATP-binding subunit ClpB
D TOPB45_0786 ATP-dependent Clp protease ATP-binding subunit clpX K03544 clpX; ATP-dependent Clp protease ATP-binding subunit ClpX
D TOPB45_1508 ATPase AAA-2 domain protein K03544 clpX; ATP-dependent Clp protease ATP-binding subunit ClpX
D TOPB45_0202 ATP-dependent hsl protease ATP-binding subunit hslU K03667 hslU; ATP-dependent HslUV protease ATP-binding subunit HslU
D TOPB45_1533 Chaperone protein dnaK K04043 dnaK; molecular chaperone DnaK
D TOPB45_1393 60 kDa chaperonin K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D TOPB45_0039 Chaperone protein dnaJ K03686 dnaJ; molecular chaperone DnaJ
D TOPB45_1318 chaperone DnaJ domain protein K03686 dnaJ; molecular chaperone DnaJ
D TOPB45_0741 heat shock protein DnaJ domain protein K05516 cbpA; curved DNA-binding protein
D TOPB45_0955 33 kDa chaperonin K04083 hslO; molecular chaperone Hsp33
D TOPB45_1534 Protein grpE K03687 GRPE; molecular chaperone GrpE
D TOPB45_1009 heat shock protein Hsp20 K13993 HSP20; HSP20 family protein
D TOPB45_1394 10 kDa chaperonin K04078 groES; chaperonin GroES
D TOPB45_0257 protease Do K04771 degP; serine protease Do [EC:3.4.21.107]
D TOPB45_1364 ATP-dependent metalloprotease FtsH K03798 ftsH; cell division protease FtsH [EC:3.4.24.-]
D TOPB45_1091 AAA ATPase central domain protein K03798 ftsH; cell division protease FtsH [EC:3.4.24.-]
D TOPB45_1051 AAA ATPase central domain protein K03798 ftsH; cell division protease FtsH [EC:3.4.24.-]
D TOPB45_0879 ATP synthase subunit a K02108 ATPF0A; F-type H+-transporting ATPase subunit a
D TOPB45_0465 hydrogenase expression/synthesis HypA K04651 hypA; hydrogenase nickel incorporation protein HypA/HybF
D TOPB45_0463 hydrogenase accessory protein HypB K04652 hypB; hydrogenase nickel incorporation protein HypB
D TOPB45_1277 hypothetical protein K03770 ppiD; peptidyl-prolyl cis-trans isomerase D [EC:5.2.1.8]
D TOPB45_1633 peptidylprolyl isomerase FKBP-type K03775 slyD; FKBP-type peptidyl-prolyl cis-trans isomerase SlyD [EC:5.2.1.8]
D TOPB45_0255 PpiC-type peptidyl-prolyl cis-trans isomerase K03769 ppiC; peptidyl-prolyl cis-trans isomerase C [EC:5.2.1.8]
D TOPB45_0258 SurA domain protein K03771 surA; peptidyl-prolyl cis-trans isomerase SurA [EC:5.2.1.8]
D TOPB45_0119 thioredoxin K03671 TXN; thioredoxin
D TOPB45_0737 disulfide bond isomerase, DsbC/G K03981 dsbC; thiol:disulfide interchange protein DsbC [EC:5.3.4.1]
C 04131 Membrane trafficking [BR:top04131]
D TOPB45_1011 Nucleoside diphosphate kinase K00940 ndk; nucleoside-diphosphate kinase [EC:2.7.4.6]
D TOPB45_0307 arsenite-activated ATPase ArsA K01551 arsA; arsenite/tail-anchored protein-transporting ATPase [EC:7.3.2.7 7.3.-.-]
D TOPB45_1384 Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D TOPB45_1386 Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D TOPB45_1042 pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40]
C 04121 Ubiquitin system
C 03051 Proteasome
C 03032 DNA replication proteins [BR:top03032]
D TOPB45_0069 histone family protein DNA-binding protein K03530 hupB; DNA-binding protein HU-beta
D TOPB45_0543 histone family protein DNA-binding protein K04764 ihfA; integration host factor subunit alpha
D TOPB45_0001 Chromosomal replication initiator protein dnaA K02313 dnaA; chromosomal replication initiator protein
D TOPB45_0187 replicative DNA helicase K02314 dnaB; replicative DNA helicase [EC:5.6.2.3]
D TOPB45_0796 DNA primase K02316 dnaG; DNA primase [EC:2.7.7.101]
D TOPB45_0245 single-strand binding protein K03111 ssb; single-strand DNA-binding protein
D TOPB45_0433 DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
D TOPB45_1485 DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
D TOPB45_1043 DNA polymerase III delta K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
D TOPB45_0845 DNA polymerase III, delta prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
D TOPB45_0992 DNA polymerase III, subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D TOPB45_0982 Ribonuclease H K03470 rnhB; ribonuclease HII [EC:3.1.26.4]
D TOPB45_0793 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
D TOPB45_1132 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TOPB45_0372 DNA gyrase, A subunit K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
D TOPB45_1486 DNA gyrase, B subunit K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
D TOPB45_1062 DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
D TOPB45_0237 reverse gyrase K03170 topG; reverse gyrase [EC:5.6.2.2 5.6.2.-]
C 03036 Chromosome and associated proteins [BR:top03036]
D TOPB45_0297 Ribonuclease 3 K03685 rnc; ribonuclease III [EC:3.1.26.3]
D TOPB45_0069 histone family protein DNA-binding protein K03530 hupB; DNA-binding protein HU-beta
D TOPB45_0543 histone family protein DNA-binding protein K04764 ihfA; integration host factor subunit alpha
D TOPB45_0741 heat shock protein DnaJ domain protein K05516 cbpA; curved DNA-binding protein
D TOPB45_0001 Chromosomal replication initiator protein dnaA K02313 dnaA; chromosomal replication initiator protein
D TOPB45_1039 SMC domain protein K03529 smc; chromosome segregation protein
D TOPB45_0102 chromosome segregation and condensation protein ScpA K05896 scpA; segregation and condensation protein A
D TOPB45_0692 chromosome segregation and condensation protein, ScpB K06024 scpB; segregation and condensation protein B
D TOPB45_0947 cell division protein FtsA K03590 ftsA; cell division protein FtsA
D TOPB45_1278 Phosphonate-transporting ATPase K09812 ftsE; cell division transport system ATP-binding protein
D TOPB45_0685 primosome, DnaD subunit K03466 ftsK; DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family
D TOPB45_0946 Polypeptide-transport-associated domain protein FtsQ-type K03589 ftsQ; cell division protein FtsQ
D TOPB45_0948 cell division protein FtsZ K03531 ftsZ; cell division protein FtsZ
D TOPB45_1593 hypothetical protein K09888 zapA; cell division protein ZapA
D TOPB45_0428 cell wall hydrolase/autolysin K01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28]
D TOPB45_0226 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system
D TOPB45_0367 cell shape determining protein, MreB/Mrl family K03569 mreB; rod shape-determining protein MreB and related proteins
D TOPB45_1555 rod shape-determining protein MreC K03570 mreC; rod shape-determining protein MreC
D TOPB45_1552 cell cycle protein K05837 rodA; rod shape determining protein RodA
D TOPB45_0222 Cobyrinic acid ac-diamide synthase K03496 parA; chromosome partitioning protein
D TOPB45_0598 parB-like partition protein K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein
D TOPB45_0949 ParB domain protein nuclease K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein
D TOPB45_1044 ParB domain protein nuclease K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein
D TOPB45_1029 tRNA uridine 5-carboxymethylaminomethyl modification enzyme mnmG K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme
D TOPB45_1213 Methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase trmFO K04094 trmFO; methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74]
D TOPB45_1577 Tyrosine recombinase xerC K03733 xerC; integrase/recombinase XerC
D TOPB45_0833 Tyrosine recombinase xerC K04763 xerD; integrase/recombinase XerD
D TOPB45_0134 ATPase-like, ParA/MinD K03593 mrp; ATP-binding protein involved in chromosome partitioning
D TOPB45_1266 ATPase-like, ParA/MinD K03593 mrp; ATP-binding protein involved in chromosome partitioning
D TOPB45_0554 GTP-binding protein engB K03978 engB; GTP-binding protein
C 03400 DNA repair and recombination proteins [BR:top03400]
D TOPB45_1338 methylated-DNA/protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D TOPB45_0617 endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D TOPB45_0191 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D TOPB45_1520 deoxyuridine 5'-triphosphate nucleotidohydrolase Dut K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D TOPB45_1435 phage SPO1 DNA polymerase-related protein K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
D TOPB45_1295 phage SPO1 DNA polymerase-related protein K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
D TOPB45_0070 formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
D TOPB45_0701 exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
D TOPB45_0144 Endonuclease V K05982 E3.1.21.7; deoxyribonuclease V [EC:3.1.21.7]
D TOPB45_0402 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D TOPB45_1132 DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TOPB45_0793 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7]
D TOPB45_0042 excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A
D TOPB45_1496 ABC transporter related protein K03701 uvrA; excinuclease ABC subunit A
D TOPB45_0309 UvrABC system protein B K03702 uvrB; excinuclease ABC subunit B
D TOPB45_0907 UvrABC system protein C K03703 uvrC; excinuclease ABC subunit C
D TOPB45_1355 UvrD/REP helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
D TOPB45_1033 UvrD/REP helicase K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
D TOPB45_0164 DNA-directed RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
D TOPB45_0163 DNA-directed RNA polymerase subunit beta' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
D TOPB45_0781 DNA-directed RNA polymerase subunit alpha K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
D TOPB45_0038 DNA-directed RNA polymerase subunit omega K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
D TOPB45_1357 transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
D TOPB45_0427 DNA mismatch repair protein mutS K03555 mutS; DNA mismatch repair protein MutS
D TOPB45_0795 MutS2 protein K07456 mutS2; DNA mismatch repair protein MutS2
D TOPB45_0218 DNA mismatch repair protein mutL K03572 mutL; DNA mismatch repair protein MutL
D TOPB45_1417 Exodeoxyribonuclease 7 large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
D TOPB45_1416 Exodeoxyribonuclease 7 small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D TOPB45_0433 DNA polymerase III, alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
D TOPB45_1485 DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
D TOPB45_1043 DNA polymerase III delta K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
D TOPB45_0845 DNA polymerase III, delta prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
D TOPB45_0992 DNA polymerase III, subunits gamma and tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D TOPB45_0245 single-strand binding protein K03111 ssb; single-strand DNA-binding protein
D TOPB45_0130 Protein recA K03553 recA; recombination protein RecA
D TOPB45_0576 Holliday junction ATP-dependent DNA helicase ruvA K03550 ruvA; holliday junction DNA helicase RuvA
D TOPB45_0549 Holliday junction ATP-dependent DNA helicase ruvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
D TOPB45_0577 Crossover junction endodeoxyribonuclease ruvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D TOPB45_1509 primosomal protein N' K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
D TOPB45_0111 hypothetical protein K03546 sbcC; DNA repair protein SbcC/Rad50
D TOPB45_0865 hypothetical protein K03546 sbcC; DNA repair protein SbcC/Rad50
D TOPB45_0132 nuclease SbcCD, D subunit K03547 sbcD; DNA repair protein SbcD/Mre11
D TOPB45_0864 metallophosphoesterase K03547 sbcD; DNA repair protein SbcD/Mre11
D TOPB45_0490 DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
D TOPB45_0614 ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
D TOPB45_0259 DNA repair protein recO K03584 recO; DNA repair protein RecO (recombination protein O)
D TOPB45_0994 Recombination protein recR K06187 recR; recombination protein RecR
D TOPB45_0930 Sigma 54 interacting domain protein K03631 recN; DNA repair protein RecN (Recombination protein N)
D TOPB45_1226 CRISPR-associated protein Cas1 K15342 cas1; CRISP-associated protein Cas1
D TOPB45_1118 CRISPR-associated protein Cas1 K15342 cas1; CRISP-associated protein Cas1
D TOPB45_0372 DNA gyrase, A subunit K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
D TOPB45_1486 DNA gyrase, B subunit K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
D TOPB45_1062 DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
D TOPB45_0069 histone family protein DNA-binding protein K03530 hupB; DNA-binding protein HU-beta
D TOPB45_0543 histone family protein DNA-binding protein K04764 ihfA; integration host factor subunit alpha
D TOPB45_1497 PHP domain protein K02347 polX; DNA polymerase (family X)
D TOPB45_0985 ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
D TOPB45_1076 phosphoesterase RecJ domain protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
C 03029 Mitochondrial biogenesis [BR:top03029]
D TOPB45_1079 translation initiation factor IF-2 K02519 infB; translation initiation factor IF-2
D TOPB45_0689 Translation initiation factor IF-3 K02520 infC; translation initiation factor IF-3
D TOPB45_1016 Elongation factor Ts K02357 tsf; elongation factor Ts
D TOPB45_0172 translation elongation factor Tu K02358 tuf; elongation factor Tu
D TOPB45_0751 translation elongation factor Tu K02358 tuf; elongation factor Tu
D TOPB45_1443 small GTP-binding protein K02355 fusA; elongation factor G
D TOPB45_0750 translation elongation factor G K02355 fusA; elongation factor G
D TOPB45_0298 GTP-binding protein Era-like-protein K03595 era; GTPase
D TOPB45_1455 Tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D TOPB45_1433 leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D TOPB45_1293 aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D TOPB45_1528 Arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D TOPB45_0597 Glutamyl-tRNA(Gln) amidotransferase subunit A K02433 gatA; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]
D TOPB45_1517 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B K02434 gatB; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]
D TOPB45_0596 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit C K02435 gatC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]
D TOPB45_0245 single-strand binding protein K03111 ssb; single-strand DNA-binding protein
D TOPB45_1573 outer membrane protein assembly complex, YaeT protein K07277 SAM50; outer membrane protein insertion porin family
D TOPB45_1533 Chaperone protein dnaK K04043 dnaK; molecular chaperone DnaK
D TOPB45_1534 Protein grpE K03687 GRPE; molecular chaperone GrpE
D TOPB45_1393 60 kDa chaperonin K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D TOPB45_1394 10 kDa chaperonin K04078 groES; chaperonin GroES
D TOPB45_0039 Chaperone protein dnaJ K03686 dnaJ; molecular chaperone DnaJ
D TOPB45_1318 chaperone DnaJ domain protein K03686 dnaJ; molecular chaperone DnaJ
D TOPB45_0236 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D TOPB45_0134 ATPase-like, ParA/MinD K03593 mrp; ATP-binding protein involved in chromosome partitioning
D TOPB45_1266 ATPase-like, ParA/MinD K03593 mrp; ATP-binding protein involved in chromosome partitioning
D TOPB45_0590 Membrane protein oxaA K03217 yidC; YidC/Oxa1 family membrane protein insertase
B
B 09183 Protein families: signaling and cellular processes
C 02000 Transporters [BR:top02000]
D TOPB45_1166 Xenobiotic-transporting ATPase K11085 msbA; ATP-binding cassette, subfamily B, bacterial MsbA [EC:7.5.2.6]
D TOPB45_0933 molybdenum ABC transporter, periplasmic molybdate-binding protein K02020 modA; molybdate transport system substrate-binding protein
D TOPB45_0932 ABC-type transporter, integral membrane subunit K02018 modB; molybdate transport system permease protein
D TOPB45_0931 Fe(3+)-transporting ATPase K02017 modC; molybdate transport system ATP-binding protein [EC:7.3.2.5]
D TOPB45_0033 Mammalian cell entry related domain protein K02067 mlaD; phospholipid/cholesterol/gamma-HCH transport system substrate-binding protein
D TOPB45_0035 protein of unknown function DUF140 K02066 mlaE; phospholipid/cholesterol/gamma-HCH transport system permease protein
D TOPB45_0034 Fe(3+)-transporting ATPase K02065 mlaF; phospholipid/cholesterol/gamma-HCH transport system ATP-binding protein
D TOPB45_0525 phosphate ABC transporter, periplasmic phosphate-binding protein K02040 pstS; phosphate transport system substrate-binding protein
D TOPB45_0526 phosphate ABC transporter, inner membrane subunit PstC K02037 pstC; phosphate transport system permease protein
D TOPB45_0527 phosphate ABC transporter, inner membrane subunit PstA K02038 pstA; phosphate transport system permease protein
D TOPB45_0528 phosphate ABC transporter, ATPase subunit K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1]
D TOPB45_0603 ABC-type transporter, periplasmic subunit K02035 ABC.PE.S; peptide/nickel transport system substrate-binding protein
D TOPB45_0049 ABC-type transporter, integral membrane subunit K02033 ABC.PE.P; peptide/nickel transport system permease protein
D TOPB45_0050 ABC-type transporter, integral membrane subunit K02034 ABC.PE.P1; peptide/nickel transport system permease protein
D TOPB45_1634 oligopeptide/dipeptide ABC transporter, ATPase subunit K02031 ddpD; peptide/nickel transport system ATP-binding protein
D TOPB45_1005 ABC-type metal ion transporter, periplasmic subunit K09815 znuA; zinc transport system substrate-binding protein
D TOPB45_1291 ABC-type transporter, integral membrane subunit K09816 znuB; zinc transport system permease protein
D TOPB45_1290 ABC transporter related protein K09817 znuC; zinc transport system ATP-binding protein [EC:7.2.2.20]
D TOPB45_1311 cobalt ABC transporter, inner membrane subunit CbiQ K02008 cbiQ; cobalt/nickel transport system permease protein
D TOPB45_1313 cobalamin (vitamin B12) biosynthesis CbiM protein K02007 cbiM; cobalt/nickel transport system permease protein
D TOPB45_1310 Fe(3+)-transporting ATPase K02006 cbiO; cobalt/nickel transport system ATP-binding protein
D TOPB45_0185 Nickel transport complex protein, NikM subunit, transmembrane K10094 cbiK; nickel transport protein
D TOPB45_0730 hypothetical protein K10094 cbiK; nickel transport protein
D TOPB45_1314 Nickel transport complex protein, NikM subunit, transmembrane K10094 cbiK; nickel transport protein
D TOPB45_1312 hypothetical protein K16915 cbiL; nickel transport protein
D TOPB45_0731 hypothetical protein K16915 cbiL; nickel transport protein
D TOPB45_0018 permease YjgP/YjgQ family protein K07091 lptF; lipopolysaccharide export system permease protein
D TOPB45_0017 permease YjgP/YjgQ family protein K11720 lptG; lipopolysaccharide export system permease protein
D TOPB45_1391 Sulfate-transporting ATPase K06861 lptB; lipopolysaccharide export system ATP-binding protein [EC:7.5.2.5]
D TOPB45_0440 ABC-2 type transporter K25181 ybhS; drug efflux transport system permease protein
D TOPB45_0439 Monosaccharide-transporting ATPase K25182 ybhF; drug efflux transport system ATP-binding protein
D TOPB45_0438 secretion protein HlyD family protein K25183 ybhG; membrane fusion protein YbhG
D TOPB45_1575 protein of unknown function DUF214 K09808 lolC_E; lipoprotein-releasing system permease protein
D TOPB45_1574 Phosphonate-transporting ATPase K09810 lolD; lipoprotein-releasing system ATP-binding protein [EC:7.6.2.-]
D TOPB45_1278 Phosphonate-transporting ATPase K09812 ftsE; cell division transport system ATP-binding protein
D TOPB45_1136 ABC-2 type transporter K01992 ABC-2.P; ABC-2 type transport system permease protein
D TOPB45_0441 ABC-2 type transporter K01992 ABC-2.P; ABC-2 type transport system permease protein
D TOPB45_0735 ABC-2 type transporter K01992 ABC-2.P; ABC-2 type transport system permease protein
D TOPB45_1135 Heme-transporting ATPase K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein
D TOPB45_0734 Sulfate-transporting ATPase K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein
D TOPB45_1067 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein
D TOPB45_1068 protein of unknown function DUF214 K02004 ABC.CD.P; putative ABC transport system permease protein
D TOPB45_1069 Phosphonate-transporting ATPase K02003 ABC.CD.A; putative ABC transport system ATP-binding protein
D TOPB45_1158 ABC transporter related protein K09013 sufC; Fe-S cluster assembly ATP-binding protein
D TOPB45_1481 major facilitator superfamily MFS_1 K03762 proP; MFS transporter, MHS family, proline/betaine transporter
D TOPB45_0574 major facilitator superfamily MFS_1 K08218 ampG; MFS transporter, PAT family, beta-lactamase induction signal transducer AmpG
D TOPB45_0997 drug resistance transporter, EmrB/QacA subfamily K03446 emrB; MFS transporter, DHA2 family, multidrug resistance protein
D TOPB45_0288 drug resistance transporter, EmrB/QacA subfamily K03446 emrB; MFS transporter, DHA2 family, multidrug resistance protein
D TOPB45_0610 TrkA-N domain protein K10716 kch; voltage-gated potassium channel
D TOPB45_0152 large conductance mechanosensitive channel protein K03282 mscL; large conductance mechanosensitive channel
D TOPB45_1538 flagellar motor stator protein MotA K02556 motA; chemotaxis protein MotA
D TOPB45_1539 OmpA/MotB domain protein K02557 motB; chemotaxis protein MotB
D TOPB45_0851 tonB-system energizer ExbB K03561 exbB; biopolymer transport protein ExbB
D TOPB45_0852 Biopolymer transport protein ExbD/TolR K03559 exbD; biopolymer transport protein ExbD
D TOPB45_0118 MotA/TolQ/ExbB proton channel K03562 tolQ; biopolymer transport protein TolQ
D TOPB45_0679 Biopolymer transport protein ExbD/TolR K03560 tolR; biopolymer transport protein TolR
D TOPB45_0840 Mg2 transporter protein CorA family protein K03284 corA; magnesium transporter
D TOPB45_1351 CBS domain containing protein K03699 tlyC; magnesium and cobalt exporter, CNNM family
D TOPB45_1352 transporter-associated region K03699 tlyC; magnesium and cobalt exporter, CNNM family
D TOPB45_0293 membrane protein involved in aromatic hydrocarbon degradation K06076 fadL; long-chain fatty acid transport protein
D TOPB45_1262 membrane protein involved in aromatic hydrocarbon degradation K06076 fadL; long-chain fatty acid transport protein
D TOPB45_0389 TonB-dependent receptor K16092 btuB; vitamin B12 transporter
D TOPB45_0825 BioY protein K16092 btuB; vitamin B12 transporter
D TOPB45_0727 TonB-dependent receptor K02014 TC.FEV.OM; iron complex outermembrane recepter protein
D TOPB45_1071 outer membrane efflux protein K12340 tolC; outer membrane protein
D TOPB45_0228 RND efflux system, outer membrane lipoprotein, NodT family K18139 oprM; outer membrane protein, multidrug efflux system
D TOPB45_1184 Carbohydrate-selective porin OprB K07267 oprB; porin
D TOPB45_1573 outer membrane protein assembly complex, YaeT protein K07277 SAM50; outer membrane protein insertion porin family
D TOPB45_0120 outer membrane assembly lipoprotein YfiO K05807 bamD; outer membrane protein assembly factor BamD
D TOPB45_1089 outer membrane autotransporter barrel domain protein K21449 ata; trimeric autotransporter adhesin
D TOPB45_1392 OstA family protein K09774 lptA; lipopolysaccharide export system protein LptA
D TOPB45_0435 Organic solvent tolerance protein K04744 lptD; LPS-assembly protein
D TOPB45_1461 transporter-associated region K06189 corC; hemolysin (HlyC) family protein
D TOPB45_1252 zinc/iron permease K07238 TC.ZIP; zinc transporter, ZIP family
D TOPB45_0227 transporter, hydrophobe/amphiphile efflux-1 (HAE1) family K18138 acrB; multidrug efflux pump
D TOPB45_1012 protein of unknown function DUF6 transmembrane K08978 TC.BAT1; bacterial/archaeal transporter family protein
D TOPB45_0649 L-lactate permease K03303 lutP; lactate permease
D TOPB45_1064 sodium/calcium exchanger membrane region K07301 yrbG; cation:H+ antiporter
D TOPB45_0241 sodium/hydrogen exchanger K26735 KEA4_5_6; K+:H+ antiporter
D TOPB45_1234 chromate transporter, chromate ion transporter (CHR) family K07240 chrA; chromate transporter
D TOPB45_0307 arsenite-activated ATPase ArsA K01551 arsA; arsenite/tail-anchored protein-transporting ATPase [EC:7.3.2.7 7.3.-.-]
D TOPB45_0959 integral membrane protein MviN K03980 murJ; putative peptidoglycan lipid II flippase
D TOPB45_0328 virulence factor MVIN family protein K03980 murJ; putative peptidoglycan lipid II flippase
D TOPB45_1124 potassium transporter K03549 kup; KUP system potassium uptake protein
D TOPB45_1073 multiple antibiotic resistance (MarC)-related protein K05595 marC; multiple antibiotic resistance protein
D TOPB45_0853 TonB family protein K03832 tonB; periplasmic protein TonB
D TOPB45_0413 OmpA/MotB domain protein K03640 pal; peptidoglycan-associated lipoprotein
D TOPB45_0680 hypothetical protein K03646 tolA; colicin import membrane protein
D TOPB45_1563 hypothetical protein K03641 tolB; TolB protein
D TOPB45_0897 Nitrate reductase K08352 phsA; thiosulfate reductase / polysulfide reductase chain A [EC:1.8.5.5]
D TOPB45_0289 secretion protein HlyD family protein K03543 emrA; membrane fusion protein, multidrug efflux system
D TOPB45_0226 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system
D TOPB45_1179 FeoA family protein K04758 feoA; ferrous iron transport protein A
D TOPB45_1182 FeoA family protein K04758 feoA; ferrous iron transport protein A
D TOPB45_0378 ferrous iron transport protein B K04759 feoB; ferrous iron transport protein B
D TOPB45_1183 ferrous iron transport protein B K04759 feoB; ferrous iron transport protein B
C 02044 Secretion system [BR:top02044]
D TOPB45_1071 outer membrane efflux protein K12340 tolC; outer membrane protein
D TOPB45_0010 Prepilin peptidase K02654 pilD; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-]
D TOPB45_0007 pilin K02650 pilA; type IV pilus assembly protein PilA
D TOPB45_0916 type II secretion system protein E K02652 pilB; type IV pilus assembly protein PilB
D TOPB45_0839 Type II secretion system F domain protein K02653 pilC; type IV pilus assembly protein PilC
D TOPB45_0917 Type II secretion system F domain protein K02653 pilC; type IV pilus assembly protein PilC
D TOPB45_0565 hypothetical protein K02662 pilM; type IV pilus assembly protein PilM
D TOPB45_1209 hypothetical protein K02663 pilN; type IV pilus assembly protein PilN
D TOPB45_1210 fimbrial assembly protein PilO K02664 pilO; type IV pilus assembly protein PilO
D TOPB45_1212 type II and III secretion system protein K02666 pilQ; type IV pilus assembly protein PilQ
D TOPB45_1512 twitching motility protein K02669 pilT; twitching motility protein PilT
D TOPB45_1513 twitching motility protein K02669 pilT; twitching motility protein PilT
D TOPB45_0006 pilin K08084 fimT; type IV fimbrial biogenesis protein FimT
D TOPB45_0923 type II and III secretion system protein K12282 mshL; MSHA biogenesis protein MshL
D TOPB45_0919 AAA ATPase K12283 mshM; MSHA biogenesis protein MshM
D TOPB45_0847 methylation site containing protein K02682 ppdD; prepilin peptidase dependent protein D
D TOPB45_1268 protein of unknown function YGGT K02221 yggT; YggT family protein
D TOPB45_1524 competence protein ComEA helix-hairpin-helix repeat protein K02237 comEA; competence protein ComEA
D TOPB45_0742 CMP/dCMP deaminase zinc-binding protein K01493 comEB; dCMP deaminase [EC:3.5.4.12]
D TOPB45_1542 DNA internalization-related competence protein ComEC/Rec2 K02238 comEC; competence protein ComEC
D TOPB45_1329 flagellar biosynthesis protein FlhA K02400 flhA; flagellar biosynthesis protein FlhA
D TOPB45_1330 flagellar biosynthetic protein FlhB K02401 flhB; flagellar biosynthesis protein FlhB
D TOPB45_0676 type III secretion exporter K04061 flhB2; flagellar biosynthesis protein
D TOPB45_0060 flagellar M-ring protein FliF K02409 fliF; flagellar M-ring protein FliF
D TOPB45_0062 Flagellar assembly protein FliH/Type III secretion system HrpE K02411 fliH; flagellar assembly protein FliH
D TOPB45_0063 ATPase, FliI/YscN family K02412 fliI; flagellum-specific ATP synthase [EC:7.4.2.8]
D TOPB45_1335 flagellar motor switch protein FliN K02417 fliN; flagellar motor switch protein FliN
D TOPB45_1334 hypothetical protein K02418 fliO; flagellar protein FliO/FliZ
D TOPB45_1333 flagellar biosynthetic protein FliP K02419 fliP; flagellar biosynthesis protein FliP
D TOPB45_1332 flagellar biosynthetic protein FliQ K02420 fliQ; flagellar biosynthesis protein FliQ
D TOPB45_1331 type III secretion system inner membrane R protein K02421 fliR; flagellar biosynthesis protein FliR
D TOPB45_0737 disulfide bond isomerase, DsbC/G K03981 dsbC; thiol:disulfide interchange protein DsbC [EC:5.3.4.1]
D TOPB45_0910 Curlin associated repeat-containing protein K04335 csgB; minor curlin subunit
D TOPB45_0909 Curlin associated repeat-containing protein K04335 csgB; minor curlin subunit
D TOPB45_0912 Curli assembly protein CsgE K04337 csgE; curli production assembly/transport component CsgE
D TOPB45_0913 Curli production assembly/transport component CsgF K04338 csgF; curli production assembly/transport component CsgF
D TOPB45_0914 Curli production assembly/transport component CsgG K06214 csgG; curli production assembly/transport component CsgG
D TOPB45_0122 Protein translocase subunit secA K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8]
D TOPB45_1006 protein-export membrane protein SecD K12257 secDF; SecD/SecF fusion protein
D TOPB45_0170 preprotein translocase, SecE subunit K03073 secE; preprotein translocase subunit SecE
D TOPB45_0045 preprotein translocase, SecG subunit K03075 secG; preprotein translocase subunit SecG
D TOPB45_0773 preprotein translocase, SecY subunit K03076 secY; preprotein translocase subunit SecY
D TOPB45_0705 signal recognition particle protein K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4]
D TOPB45_0416 signal recognition particle-docking protein FtsY K03110 ftsY; fused signal recognition particle receptor
D TOPB45_1214 preprotein translocase, YajC subunit K03210 yajC; preprotein translocase subunit YajC
D TOPB45_0590 Membrane protein oxaA K03217 yidC; YidC/Oxa1 family membrane protein insertase
D TOPB45_1402 Sec-independent protein translocase protein tatA/E-like protein K03116 tatA; sec-independent protein translocase protein TatA
D TOPB45_1615 twin-arginine translocation protein, TatB subunit K03117 tatB; sec-independent protein translocase protein TatB
D TOPB45_1401 Sec-independent protein translocase, TatC subunit K03118 tatC; sec-independent protein translocase protein TatC
D TOPB45_0066 Sec-independent periplasmic protein translocase K03118 tatC; sec-independent protein translocase protein TatC
D TOPB45_1614 Sec-independent periplasmic protein translocase K03118 tatC; sec-independent protein translocase protein TatC
C 02042 Bacterial toxins [BR:top02042]
D TOPB45_1351 CBS domain containing protein K03699 tlyC; magnesium and cobalt exporter, CNNM family
D TOPB45_1352 transporter-associated region K03699 tlyC; magnesium and cobalt exporter, CNNM family
C 02022 Two-component system [BR:top02022]
D TOPB45_0792 integral membrane sensor signal transduction histidine kinase K13598 ntrY; two-component system, NtrC family, nitrogen regulation sensor histidine kinase NtrY [EC:2.7.13.3]
D TOPB45_0824 two component, sigma54 specific, transcriptional regulator, Fis family K13599 ntrX; two-component system, NtrC family, nitrogen regulation response regulator NtrX
D TOPB45_1247 integral membrane sensor signal transduction histidine kinase K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
D TOPB45_1469 CheA signal transduction histidine kinase K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
D TOPB45_1321 response regulator receiver protein K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
D TOPB45_1325 response regulator receiver protein K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
D TOPB45_1320 response regulator receiver modulated CheB methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C 02035 Bacterial motility proteins [BR:top02035]
D TOPB45_1469 CheA signal transduction histidine kinase K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
D TOPB45_1468 CheW protein K03408 cheW; purine-binding chemotaxis protein CheW
D TOPB45_1466 hypothetical protein K03409 cheX; chemotaxis protein CheX
D TOPB45_1319 MCP methyltransferase, CheR-type K00575 cheR; chemotaxis protein methyltransferase CheR [EC:2.1.1.80]
D TOPB45_1320 response regulator receiver modulated CheB methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
D TOPB45_1321 response regulator receiver protein K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
D TOPB45_1325 response regulator receiver protein K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
D TOPB45_0550 methyl-accepting chemotaxis sensory transducer K03406 mcp; methyl-accepting chemotaxis protein
D TOPB45_1467 methyl-accepting chemotaxis sensory transducer K03406 mcp; methyl-accepting chemotaxis protein
D TOPB45_0062 Flagellar assembly protein FliH/Type III secretion system HrpE K02411 fliH; flagellar assembly protein FliH
D TOPB45_0063 ATPase, FliI/YscN family K02412 fliI; flagellum-specific ATP synthase [EC:7.4.2.8]
D TOPB45_0064 hypothetical protein K02413 fliJ; flagellar protein FliJ
D TOPB45_1334 hypothetical protein K02418 fliO; flagellar protein FliO/FliZ
D TOPB45_1333 flagellar biosynthetic protein FliP K02419 fliP; flagellar biosynthesis protein FliP
D TOPB45_1332 flagellar biosynthetic protein FliQ K02420 fliQ; flagellar biosynthesis protein FliQ
D TOPB45_1331 type III secretion system inner membrane R protein K02421 fliR; flagellar biosynthesis protein FliR
D TOPB45_1329 flagellar biosynthesis protein FlhA K02400 flhA; flagellar biosynthesis protein FlhA
D TOPB45_1330 flagellar biosynthetic protein FlhB K02401 flhB; flagellar biosynthesis protein FlhB
D TOPB45_0061 flagellar motor switch protein FliG K02410 fliG; flagellar motor switch protein FliG
D TOPB45_1336 flagellar motor switch protein FliM K02416 fliM; flagellar motor switch protein FliM
D TOPB45_1335 flagellar motor switch protein FliN K02417 fliN; flagellar motor switch protein FliN
D TOPB45_0060 flagellar M-ring protein FliF K02409 fliF; flagellar M-ring protein FliF
D TOPB45_1568 Flagellar P-ring protein K02394 flgI; flagellar P-ring protein FlgI
D TOPB45_1570 flagella basal body P-ring formation protein FlgA K02386 flgA; flagellar basal body P-ring formation protein FlgA
D TOPB45_1569 Flagellar L-ring protein K02393 flgH; flagellar L-ring protein FlgH
D TOPB45_1337 flagellar basal body-associated protein FliL K02415 fliL; flagellar protein FliL
D TOPB45_0059 Flagellar hook-basal body complex protein fliE K02408 fliE; flagellar hook-basal body complex protein FliE
D TOPB45_0089 hypothetical protein K02414 fliK; flagellar hook-length control protein FliK
D TOPB45_0057 flagellar basal-body rod protein FlgB K02387 flgB; flagellar basal-body rod protein FlgB
D TOPB45_0058 flagellar basal-body rod protein FlgC K02388 flgC; flagellar basal-body rod protein FlgC
D TOPB45_0088 flagellar hook capping protein K02389 flgD; flagellar basal-body rod modification protein FlgD
D TOPB45_1572 flagellar basal-body rod protein FlgF K02391 flgF; flagellar basal-body rod protein FlgF
D TOPB45_1571 flagellar basal-body rod protein FlgG K02392 flgG; flagellar basal-body rod protein FlgG
D TOPB45_1567 hypothetical protein K02395 flgJ; peptidoglycan hydrolase FlgJ
D TOPB45_0087 flagellar hook-basal body protein K02390 flgE; flagellar hook protein FlgE
D TOPB45_0086 flagellar hook-basal body protein K02390 flgE; flagellar hook protein FlgE
D TOPB45_1565 flagellar hook-associated protein FlgK K02396 flgK; flagellar hook-associated protein 1
D TOPB45_1564 flagellar hook-associated protein 3 K02397 flgL; flagellar hook-associated protein 3 FlgL
D TOPB45_1345 flagellin domain protein K02406 fliC; flagellin
D TOPB45_1630 flagellar hook-associated 2 domain-containing protein K02407 fliD; flagellar hook-associated protein 2
D TOPB45_1629 flagellar protein FliS K02422 fliS; flagellar secretion chaperone FliS
D TOPB45_1326 RNA polymerase, sigma 28 subunit, FliA/WhiG K02405 fliA; RNA polymerase sigma factor FliA
D TOPB45_1538 flagellar motor stator protein MotA K02556 motA; chemotaxis protein MotA
D TOPB45_1539 OmpA/MotB domain protein K02557 motB; chemotaxis protein MotB
D TOPB45_0054 sigma54 specific transcriptional regulator, Fis family K10941 flrA; sigma-54 dependent transcriptional regulator, flagellar regulatory protein
D TOPB45_0299 flagellar biosynthesis anti-sigma factor protein FlgM K02398 flgM; negative regulator of flagellin synthesis FlgM
D TOPB45_1631 flagellar protein FlaG protein K06603 flaG; flagellar protein FlaG
D TOPB45_1328 GTP-binding signal recognition particle SRP54 G-domain protein K02404 flhF; flagellar biosynthesis protein FlhF
D TOPB45_1327 Cobyrinic acid ac-diamide synthase K04562 flhG; flagellar biosynthesis protein FlhG
D TOPB45_1512 twitching motility protein K02669 pilT; twitching motility protein PilT
D TOPB45_1513 twitching motility protein K02669 pilT; twitching motility protein PilT
D TOPB45_0007 pilin K02650 pilA; type IV pilus assembly protein PilA
D TOPB45_0916 type II secretion system protein E K02652 pilB; type IV pilus assembly protein PilB
D TOPB45_0839 Type II secretion system F domain protein K02653 pilC; type IV pilus assembly protein PilC
D TOPB45_0917 Type II secretion system F domain protein K02653 pilC; type IV pilus assembly protein PilC
D TOPB45_0010 Prepilin peptidase K02654 pilD; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-]
D TOPB45_1212 type II and III secretion system protein K02666 pilQ; type IV pilus assembly protein PilQ
D TOPB45_1210 fimbrial assembly protein PilO K02664 pilO; type IV pilus assembly protein PilO
D TOPB45_1209 hypothetical protein K02663 pilN; type IV pilus assembly protein PilN
D TOPB45_0565 hypothetical protein K02662 pilM; type IV pilus assembly protein PilM
C 03037 Cilium and associated proteins
C 04812 Cytoskeleton proteins [BR:top04812]
D TOPB45_0950 UPF0103/Mediator of ErbB2-driven cell motility-containing protein K06990 MEMO1; MEMO1 family protein
D TOPB45_1081 UPF0103/Mediator of ErbB2-driven cell motility-containing protein K06990 MEMO1; MEMO1 family protein
D TOPB45_0367 cell shape determining protein, MreB/Mrl family K03569 mreB; rod shape-determining protein MreB and related proteins
D TOPB45_0948 cell division protein FtsZ K03531 ftsZ; cell division protein FtsZ
D TOPB45_0947 cell division protein FtsA K03590 ftsA; cell division protein FtsA
D TOPB45_0222 Cobyrinic acid ac-diamide synthase K03496 parA; chromosome partitioning protein
D TOPB45_0598 parB-like partition protein K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein
D TOPB45_0949 ParB domain protein nuclease K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein
D TOPB45_1044 ParB domain protein nuclease K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein
C 04147 Exosome [BR:top04147]
D TOPB45_0128 Enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11]
D TOPB45_1384 Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D TOPB45_1386 Glyceraldehyde-3-phosphate dehydrogenase (phosphorylating) K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12]
D TOPB45_0105 Phosphoglycerate kinase K00927 PGK; phosphoglycerate kinase [EC:2.7.2.3]
D TOPB45_1042 pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40]
D TOPB45_0556 peroxiredoxin K03386 PRDX2_4; peroxiredoxin 2/4 [EC:1.11.1.24]
D TOPB45_1393 60 kDa chaperonin K04077 groEL; chaperonin GroEL [EC:5.6.1.7]
D TOPB45_1533 Chaperone protein dnaK K04043 dnaK; molecular chaperone DnaK
D TOPB45_0294 phosphoglucose isomerase (PGI) K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9]
D TOPB45_0838 inosine-5'-monophosphate dehydrogenase K00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205]
D TOPB45_0172 translation elongation factor Tu K02358 tuf; elongation factor Tu
D TOPB45_0751 translation elongation factor Tu K02358 tuf; elongation factor Tu
D TOPB45_1027 ATPase, P-type (transporting), HAD superfamily, subfamily IC K01539 ATP1A; sodium/potassium-transporting ATPase subunit alpha [EC:7.2.2.13]
D TOPB45_1185 histidine triad (HIT) protein K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]
D TOPB45_1300 o-succinylbenzoate--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
D TOPB45_0621 Adenosylhomocysteinase K01251 AHCY; adenosylhomocysteinase [EC:3.13.2.1]
D TOPB45_0774 Adenylate kinase K00939 adk; adenylate kinase [EC:2.7.4.3]
D TOPB45_1620 Argininosuccinate lyase K01755 argH; argininosuccinate lyase [EC:4.3.2.1]
D TOPB45_0486 Argininosuccinate synthase K01940 argG; argininosuccinate synthase [EC:6.3.4.5]
D TOPB45_1257 glutamine synthetase, type I K01915 glnA; glutamine synthetase [EC:6.3.1.2]
D TOPB45_0295 Porphobilinogen synthase K01698 hemB; porphobilinogen synthase [EC:4.2.1.24]
D TOPB45_0023 D-3-phosphoglycerate dehydrogenase K00058 serA; D-3-phosphoglycerate dehydrogenase / 2-oxoglutarate reductase [EC:1.1.1.95 1.1.1.399]
D TOPB45_1505 Phosphoribosylaminoimidazolecarboxamide formyltransferase K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]
D TOPB45_0026 Phosphoribosylaminoimidazolecarboxamide formyltransferase K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10]
D TOPB45_1473 peptidase M48 Ste24p K06013 STE24; STE24 endopeptidase [EC:3.4.24.84]
D TOPB45_1296 Electron transfer flavoprotein alpha subunit K03522 fixB; electron transfer flavoprotein alpha subunit
D TOPB45_0104 triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1]
C 02048 Prokaryotic defense system [BR:top02048]
D TOPB45_1226 CRISPR-associated protein Cas1 K15342 cas1; CRISP-associated protein Cas1
D TOPB45_1118 CRISPR-associated protein Cas1 K15342 cas1; CRISP-associated protein Cas1
D TOPB45_1227 CRISPR-associated protein Cas2 K09951 cas2; CRISPR-associated protein Cas2
D TOPB45_1117 CRISPR-associated protein Cas2 K09951 cas2; CRISPR-associated protein Cas2
D TOPB45_1224 CRISPR-associated helicase Cas3 K07012 cas3; CRISPR-associated endonuclease/helicase Cas3 [EC:3.1.-.- 5.6.2.4]
D TOPB45_1225 CRISPR-associated protein Cas4 K07464 cas4; CRISPR-associated exonuclease Cas4 [EC:3.1.12.1]
D TOPB45_1223 CRISPR-associated protein Cas5 family K19090 cas5t; CRISPR-associated protein Cas5t
D TOPB45_1220 CRISPR-associated protein Cas6 K19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]
D TOPB45_1114 Protein of unknown function DUF2276 K19091 cas6; CRISPR-associated endoribonuclease Cas6 [EC:3.1.-.-]
D TOPB45_1109 CRISPR-associated protein, Csm1 family K07016 csm1; CRISPR-associated protein Csm1
D TOPB45_1110 CRISPR-associated protein TM1810 domain protein K19138 csm2; CRISPR-associated protein Csm2
D TOPB45_1111 CRISPR-associated RAMP protein, Csm3 family K09002 csm3; CRISPR-associated protein Csm3
D TOPB45_1112 CRISPR-associated RAMP protein, Csm4 family K19139 csm4; CRISPR-associated protein Csm4
D TOPB45_1113 CRISPR-associated RAMP protein, Csm5 family K19140 csm5; CRISPR-associated protein Csm5
D TOPB45_1115 CRISPR-associated protein, MJ1666 family K19143 csx1; CRISPR-associated protein Csx1
D TOPB45_0151 type I site-specific deoxyribonuclease, HsdR family K01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3]
D TOPB45_0148 restriction modification system DNA specificity domain protein K01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3]
D TOPB45_0145 Site-specific DNA-methyltransferase (adenine-specific) K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72]
D TOPB45_1049 hypothetical protein K07317 K07317; adenine-specific DNA-methyltransferase [EC:2.1.1.72]
D TOPB45_1159 DNA methylase N-4/N-6 domain protein K24451 zim; modification methylase
D TOPB45_1381 HNH endonuclease K07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-]
D TOPB45_1102 transcriptional regulator, AbrB family K19156 prlF; antitoxin PrlF
D TOPB45_0948 cell division protein FtsZ K03531 ftsZ; cell division protein FtsZ
D TOPB45_0367 cell shape determining protein, MreB/Mrl family K03569 mreB; rod shape-determining protein MreB and related proteins
D TOPB45_1082 glutamyl-tRNA synthetase K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D TOPB45_0236 Cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
C 04030 G protein-coupled receptors
C 04050 Cytokine receptors
C 04054 Pattern recognition receptors
C 03310 Nuclear receptors
C 04040 Ion channels
C 04031 GTP-binding proteins
C 04052 Cytokines and neuropeptides
C 04515 Cell adhesion molecules
C 04090 CD molecules
C 01504 Antimicrobial resistance genes [BR:top01504]
D TOPB45_0226 efflux transporter, RND family, MFP subunit K03585 acrA; membrane fusion protein, multidrug efflux system
D TOPB45_0227 transporter, hydrophobe/amphiphile efflux-1 (HAE1) family K18138 acrB; multidrug efflux pump
D TOPB45_0228 RND efflux system, outer membrane lipoprotein, NodT family K18139 oprM; outer membrane protein, multidrug efflux system
D TOPB45_1071 outer membrane efflux protein K12340 tolC; outer membrane protein
C 00535 Proteoglycans
C 00536 Glycosaminoglycan binding proteins
C 00537 Glycosylphosphatidylinositol (GPI)-anchored proteins
C 04091 Lectins
C 04990 Domain-containing proteins not elsewhere classified
B
B 09185 Viral protein families
C 03200 Viral proteins
C 03210 Viral fusion proteins
B
B 09184 RNA family
C 03100 Non-coding RNAs [BR:top03100]
D TOPB45_R0010 tRNA-Ala K14218 tRNA-Ala; tRNA Ala
D TOPB45_R0013 tRNA-Ala K14218 tRNA-Ala; tRNA Ala
D TOPB45_R0045 tRNA-Ala K14218 tRNA-Ala; tRNA Ala
D TOPB45_R0042 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D TOPB45_R0035 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D TOPB45_R0047 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D TOPB45_R0014 tRNA-Arg K14219 tRNA-Arg; tRNA Arg
D TOPB45_R0031 tRNA-Asn K14220 tRNA-Asn; tRNA Asn
D TOPB45_R0033 tRNA-Asp K14221 tRNA-Asp; tRNA Asp
D TOPB45_R0044 tRNA-Cys K14222 tRNA-Cys; tRNA Cys
D TOPB45_R0017 tRNA-Gln K14223 tRNA-Gln; tRNA Gln
D TOPB45_R0024 tRNA-Gln K14223 tRNA-Gln; tRNA Gln
D TOPB45_R0051 tRNA-Glu K14224 tRNA-Glu; tRNA Glu
D TOPB45_R0027 tRNA-Glu K14224 tRNA-Glu; tRNA Glu
D TOPB45_R0004 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D TOPB45_R0046 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D TOPB45_R0049 tRNA-Gly K14225 tRNA-Gly; tRNA Gly
D TOPB45_R0036 tRNA-His K14226 tRNA-His; tRNA His
D TOPB45_R0011 tRNA-Ile K14227 tRNA-Ile; tRNA Ile
D TOPB45_R0001 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D TOPB45_R0028 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D TOPB45_R0015 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D TOPB45_R0037 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D TOPB45_R0029 tRNA-Leu K14228 tRNA-Leu; tRNA Leu
D TOPB45_R0025 tRNA-Lys K14229 tRNA-Lys; tRNA Lys
D TOPB45_R0050 tRNA-Lys K14229 tRNA-Lys; tRNA Lys
D TOPB45_R0052 tRNA-Met K14230 tRNA-Met; tRNA Met
D TOPB45_R0041 tRNA-Met K14230 tRNA-Met; tRNA Met
D TOPB45_R0043 tRNA-Met K14230 tRNA-Met; tRNA Met
D TOPB45_R0034 tRNA-Phe K14231 tRNA-Phe; tRNA Phe
D TOPB45_R0038 tRNA-Pro K14232 tRNA-Pro; tRNA Pro
D TOPB45_R0039 tRNA-Pro K14232 tRNA-Pro; tRNA Pro
D TOPB45_R0007 tRNA-Pro K14232 tRNA-Pro; tRNA Pro
D TOPB45_R0021 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D TOPB45_R0023 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D TOPB45_R0018 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D TOPB45_R0040 tRNA-Ser K14233 tRNA-Ser; tRNA Ser
D TOPB45_R0003 tRNA-Thr K14234 tRNA-Thr; tRNA Thr
D TOPB45_R0016 tRNA-Thr K14234 tRNA-Thr; tRNA Thr
D TOPB45_R0022 tRNA-Thr K14234 tRNA-Thr; tRNA Thr
D TOPB45_R0002 tRNA-Trp K14235 tRNA-Trp; tRNA Trp
D TOPB45_R0005 tRNA-Tyr K14236 tRNA-Tyr; tRNA Tyr
D TOPB45_R0032 tRNA-Val K14237 tRNA-Val; tRNA Val
D TOPB45_R0030 tRNA-Val K14237 tRNA-Val; tRNA Val
D TOPB45_R0006 tRNA-Val K14237 tRNA-Val; tRNA Val
D TOPB45_R0020 tRNA-Sec K14238 tRNA-Sec; tRNA Sec
D TOPB45_R0012 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA
D TOPB45_R0009 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA
D TOPB45_R0008 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA
D TOPB45_R0019 ffs; SRP RNA; RNA component of signal recognition particle K01983 ffs; SRP RNA
D TOPB45_R0026 rnpB; RNA component of RNaseP K01978 rnpB; M1 RNA
D TOPB45_R0048 ssrA; tmRNA as predicted by Rfam (RF00023), score 222.75 K15035 ssrA; transfer-messenger RNA
#
A09190 Not Included in Pathway or Brite
B
B 09191 Unclassified: metabolism
C 99980 Enzymes with EC numbers
D TOPB45_0643 Indolepyruvate ferredoxin oxidoreductase K00179 iorA; indolepyruvate ferredoxin oxidoreductase, alpha subunit [EC:1.2.7.8]
D TOPB45_0648 Indolepyruvate ferredoxin oxidoreductase K00180 iorB; indolepyruvate ferredoxin oxidoreductase, beta subunit [EC:1.2.7.8]
D TOPB45_0886 hydrogenase (NiFe) small subunit HydA K18008 hydA; [NiFe] hydrogenase small subunit [EC:1.12.2.1]
D TOPB45_0541 desulfoferrodoxin K05919 dfx; superoxide reductase [EC:1.15.1.2]
D TOPB45_1309 Ferroxidase K02217 ftnA; ferritin [EC:1.16.3.2]
D TOPB45_1253 hypothetical protein K04068 nrdG; anaerobic ribonucleoside-triphosphate reductase activating protein [EC:1.97.1.4]
D TOPB45_0312 anaerobic ribonucleoside-triphosphate reductase activating protein K04069 pflA; pyruvate formate lyase activating enzyme [EC:1.97.1.4]
D TOPB45_1372 Radical SAM domain protein K04069 pflA; pyruvate formate lyase activating enzyme [EC:1.97.1.4]
D TOPB45_0021 Radical SAM domain protein K04069 pflA; pyruvate formate lyase activating enzyme [EC:1.97.1.4]
D TOPB45_0830 Radical SAM domain protein K04070 pflX; putative pyruvate formate lyase activating enzyme [EC:1.97.1.4]
D TOPB45_1143 Protein-L-isoaspartate O-methyltransferase K00573 E2.1.1.77; protein-L-isoaspartate(D-aspartate) O-methyltransferase [EC:2.1.1.77]
D TOPB45_1462 Apolipoprotein N-acyltransferase K03820 lnt; apolipoprotein N-acyltransferase [EC:2.3.1.269]
D TOPB45_0871 transglutaminase domain-containing protein K22452 tgpA; protein-glutamine gamma-glutamyltransferase [EC:2.3.2.13]
D TOPB45_1193 protein of unknown function DUF43 K07057 bpsA; N4-bis(aminopropyl)spermidine synthase [EC:2.5.1.128]
D TOPB45_0616 Prolipoprotein diacylglyceryl transferase K13292 lgt; phosphatidylglycerol---prolipoprotein diacylglyceryl transferase [EC:2.5.1.145]
D TOPB45_1366 Conserved hypothetical protein CHP00159 K18672 dacA; diadenylate cyclase [EC:2.7.7.85]
D TOPB45_0640 CDP-alcohol phosphatidyltransferase K17884 E2.7.8.39; archaetidylinositol phosphate synthase [EC:2.7.8.39]
D TOPB45_1339 Appr-1-p processing domain protein K23518 MACROD; O-acetyl-ADP-ribose deacetylase [EC:3.1.1.106]
D TOPB45_0284 4-hydroxybenzoyl-CoA thioesterase K07107 ybgC; acyl-CoA thioester hydrolase [EC:3.1.2.-]
D TOPB45_1590 PHP domain protein K07053 E3.1.3.97; 3',5'-nucleoside bisphosphate phosphatase [EC:3.1.3.97]
D TOPB45_0801 phosphohistidine phosphatase, SixA K08296 sixA; phosphohistidine phosphatase [EC:3.1.3.-]
D TOPB45_1061 protein of unknown function DUF89 K09116 K09116; damage-control phosphatase, subfamily I [EC:3.1.3.-]
D TOPB45_0113 response regulator receiver modulated metal dependent phosphohydrolase K07814 K07814; cyclic di-GMP phosphodiesterase [EC:3.1.4.-]
D TOPB45_1292 hydrolase, TatD family K03424 tatD; TatD DNase family protein [EC:3.1.21.-]
D TOPB45_1627 nuclease (SNase domain-containing protein) K01174 nuc; micrococcal nuclease [EC:3.1.31.1]
D TOPB45_1596 Peptide deformylase K01462 PDF; peptide deformylase [EC:3.5.1.88]
D TOPB45_0869 ATPase associated with various cellular activities AAA_3 K03924 moxR; MoxR-like ATPase [EC:3.6.3.-]
D TOPB45_0052 ATPase associated with various cellular activities AAA_5 K03924 moxR; MoxR-like ATPase [EC:3.6.3.-]
D TOPB45_0928 protein of unknown function DUF62 K22205 E3.13.2.3; S-adenosyl-L-methionine hydrolase (adenosine-forming) [EC:3.13.2.3]
D TOPB45_0012 YjeF-related protein K23997 nnr; ADP-dependent NAD(P)H-hydrate dehydratase / NAD(P)H-hydrate epimerase [EC:4.2.1.136 5.1.99.6]
D TOPB45_1238 carbohydrate kinase-related protein K23997 nnr; ADP-dependent NAD(P)H-hydrate dehydratase / NAD(P)H-hydrate epimerase [EC:4.2.1.136 5.1.99.6]
D TOPB45_0242 peptidylprolyl isomerase FKBP-type K01802 E5.2.1.8; peptidylprolyl isomerase [EC:5.2.1.8]
D TOPB45_1447 CoA-substrate-specific enzyme activase K23876 hgdC; (R)-2-hydroxyacyl-CoA dehydratese activating ATPase [EC:5.6.1.9]
D TOPB45_0927 UDP-N-acetylmuramate--L-alanine ligase K02558 mpl; UDP-N-acetylmuramate: L-alanyl-gamma-D-glutamyl-meso-diaminopimelate ligase [EC:6.3.2.45]
D TOPB45_0975 RNA 3'-phosphate cyclase K01974 RTCA; RNA 3'-terminal phosphate cyclase (ATP) [EC:6.5.1.4]
D TOPB45_0977 Y414 protein K07468 K07468; DNA/RNA ligase [EC:6.5.1.-]
D TOPB45_1482 magnesium-translocating P-type ATPase K01531 mgtA; P-type Mg2+ transporter [EC:7.2.2.14]
C 99981 Carbohydrate metabolism
D TOPB45_1375 sugar fermentation stimulation protein K06206 sfsA; sugar fermentation stimulation protein A
D TOPB45_0043 putative signal transduction protein with CBS domains K04767 acuB; acetoin utilization protein AcuB
C 99982 Energy metabolism
D TOPB45_1409 Protein fdhD K02379 fdhD; FdhD protein
D TOPB45_1264 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein K05337 fer; ferredoxin
D TOPB45_0175 fumarate reductase/succinate dehydrogenase flavoprotein domain protein K16885 qmoA; quinone-modifying oxidoreductase, subunit QmoA
D TOPB45_0174 methyl-viologen-reducing hydrogenase delta subunit K16886 qmoB; quinone-modifying oxidoreductase, subunit QmoB
D TOPB45_0173 Heterodisulfide reductase subunit C K16887 qmoC; quinone-modifying oxidoreductase, subunit QmoC
D TOPB45_1370 4Fe-4S ferredoxin iron-sulfur binding domain-containing protein K02574 napH; ferredoxin-type protein NapH
D TOPB45_1297 Electron transfer flavoprotein alpha/beta-subunit K03521 fixA; electron transfer flavoprotein beta subunit
D TOPB45_1525 sulfur relay protein, TusE/DsrC/DsvC family K23077 dsrC; dissimilatory sulfite reductase related protein
C 99983 Lipid metabolism
C 99984 Nucleotide metabolism
C 99985 Amino acid metabolism
D TOPB45_1543 protein of unknown function UPF0001 K06997 yggS; PLP dependent protein
C 99986 Glycan metabolism
D TOPB45_0953 conserved protein YrvD K08992 lapA; lipopolysaccharide assembly protein A
D TOPB45_1453 integral membrane protein K07027 K07027; glycosyltransferase 2 family protein
D TOPB45_1074 hypothetical protein K07027 K07027; glycosyltransferase 2 family protein
C 99987 Cofactor metabolism
D TOPB45_1603 molybdopterin-guanine dinucleotide biosynthesis protein MobB K03753 mobB; molybdopterin-guanine dinucleotide biosynthesis adapter protein
C 99988 Secondary metabolism
C 99999 Others
B
B 09192 Unclassified: genetic information processing
C 99973 Transcription
D TOPB45_1580 cold-shock DNA-binding domain protein K03704 cspA; cold shock protein
D TOPB45_1171 UPF0296 protein K09777 remA; extracellular matrix regulatory protein A
C 99974 Translation
D TOPB45_1410 RNA-metabolising metallo-beta-lactamase K07576 K07576; metallo-beta-lactamase family protein
C 99975 Protein processing
D TOPB45_0784 Trigger factor K03545 tig; trigger factor
D TOPB45_0499 formate dehydrogenase accessory protein K02380 fdhE; FdhE protein
D TOPB45_0110 SsrA-binding protein K03664 smpB; SsrA-binding protein
D TOPB45_0883 hydrogenase assembly chaperone hypC/hupF K04653 hypC; hydrogenase expression/formation protein HypC
D TOPB45_0884 hydrogenase expression/formation protein HypD K04654 hypD; hydrogenase expression/formation protein HypD
D TOPB45_0464 hydrogenase expression/formation protein HypE K04655 hypE; hydrogenase expression/formation protein HypE
D TOPB45_0418 Acylphosphatase K04656 hypF; hydrogenase maturation protein HypF
D TOPB45_0881 Mg chelatase, subunit ChlI K07391 comM; magnesium chelatase family protein
D TOPB45_1133 ResB family protein K07399 resB; cytochrome c biogenesis protein
D TOPB45_1436 protein of unknown function DUF107 K07403 nfeD; membrane-bound serine protease (ClpP class)
C 99976 Replication and repair
D TOPB45_0474 DNA repair protein RadC K03630 radC; DNA repair protein RadC
D TOPB45_0266 HhH-GPD family protein K07457 K07457; endonuclease III related protein
D TOPB45_0983 UPF0102 protein yraN K07460 yraN; putative endonuclease
D TOPB45_0996 DNA protecting protein DprA K04096 smf; DNA processing protein
D TOPB45_1261 transposase IS116/IS110/IS902 family protein K07486 K07486; transposase
D TOPB45_1621 hypothetical protein K07491 rayT; REP-associated tyrosine transposase
C 99979 Viral proteins
C 99998 Others
D TOPB45_0993 UPF0133 protein ybaB K09747 ebfC; nucleoid-associated protein EbfC
B
B 09193 Unclassified: signaling and cellular processes
C 99977 Transport
D TOPB45_0729 amino acid permease-associated region K03294 TC.APA; basic amino acid/polyamine antiporter, APA family
D TOPB45_1072 amino acid permease-associated region K03294 TC.APA; basic amino acid/polyamine antiporter, APA family
D TOPB45_0625 phosphate transporter K03306 TC.PIT; inorganic phosphate transporter, PiT family
C 99978 Cell growth
D TOPB45_0722 Cobyrinic acid ac-diamide synthase K07321 cooC; CO dehydrogenase maturation factor
D TOPB45_0591 hypothetical protein K06346 jag; spoIIIJ-associated protein
C 99993 Cell motility
C 99995 Signaling proteins
D TOPB45_1267 PhoH family protein K06217 phoH; phosphate starvation-inducible protein PhoH and related proteins
C 99992 Structural proteins
D TOPB45_0684 outer membrane lipoprotein carrier protein LolA K03634 lolA; outer membrane lipoprotein carrier protein
D TOPB45_0412 outer membrane chaperone Skp (OmpH) K06142 hlpA; outer membrane protein
D TOPB45_0726 outer membrane lipoprotein Slp K07285 slp; outer membrane lipoprotein
D TOPB45_1070 efflux transporter, RND family, MFP subunit K02005 ABC.CD.TX; HlyD family secretion protein
C 99994 Others
D TOPB45_1140 phosphate uptake regulator, PhoU K02039 phoU; phosphate transport system protein
D TOPB45_0495 CutA1 divalent ion tolerance protein K03926 cutA; periplasmic divalent cation tolerance protein
D TOPB45_0569 hemerythrin-like metal-binding protein K07216 hr; hemerythrin
D TOPB45_0500 molybdenum cofactor synthesis domain protein K03750 moeA; molybdopterin molybdotransferase [EC:2.10.1.1]
B
B 09194 Poorly characterized
C 99996 General function prediction only
D TOPB45_0720 Colicin V production protein K03558 cvpA; membrane protein required for colicin V production
D TOPB45_1024 transport-associated protein K04065 osmY; hyperosmotically inducible periplasmic protein
D TOPB45_1157 SufBD protein K09014 sufB; Fe-S cluster assembly protein SufB
D TOPB45_0501 ribonuclease BN K07058 K07058; membrane protein
D TOPB45_1527 Sporulation domain-containing protein K03749 dedD; DedD protein
D TOPB45_1122 protein of unknown function DUF202 K00389 yidH; putative membrane protein
C 99997 Function unknown
D TOPB45_0634 DRTGG domain protein K06873 K06873; uncharacterized protein
D TOPB45_0103 CoA-binding domain protein K06929 K06929; uncharacterized protein
D TOPB45_0678 protein of unknown function UPF0153 K06940 K06940; uncharacterized protein
D TOPB45_0386 protein of unknown function UPF0153 K06940 K06940; uncharacterized protein
D TOPB45_1605 protein of unknown function UPF0153 K06940 K06940; uncharacterized protein
D TOPB45_0216 metal dependent phosphohydrolase K06950 K06950; uncharacterized protein
D TOPB45_1021 metal dependent phosphohydrolase K06950 K06950; uncharacterized protein
D TOPB45_0707 UPF0109 protein K06960 K06960; uncharacterized protein
D TOPB45_1395 hypothetical protein K07028 K07028; uncharacterized protein
D TOPB45_1103 PilT protein domain protein K07064 K07064; uncharacterized protein
D TOPB45_0335 PilT protein domain protein K07065 K07065; uncharacterized protein
D TOPB45_0357 PilT protein domain protein K07065 K07065; uncharacterized protein
D TOPB45_0609 domain of unknown function DUF1731 K07071 K07071; uncharacterized protein
D TOPB45_0889 Protein of unknown function DUF318, transmembrane K07089 K07089; uncharacterized protein
D TOPB45_0468 protein of unknown function DUF81 K07090 K07090; uncharacterized protein
D TOPB45_1243 protein of unknown function DUF81 K07090 K07090; uncharacterized protein
D TOPB45_0799 protein of unknown function DUF81 K07090 K07090; uncharacterized protein
D TOPB45_0892 protein of unknown function DUF81 K07090 K07090; uncharacterized protein
D TOPB45_0901 protein of unknown function DUF81 K07090 K07090; uncharacterized protein
D TOPB45_0900 protein of unknown function DUF81 K07090 K07090; uncharacterized protein
D TOPB45_0562 phosphodiesterase, MJ0936 family K07095 K07095; uncharacterized protein
D TOPB45_0419 metallophosphoesterase K07098 K07098; uncharacterized protein
D TOPB45_0579 protein of unknown function DUF395 YeeE/YedE K07112 K07112; uncharacterized protein
D TOPB45_1241 hypothetical protein K07112 K07112; uncharacterized protein
D TOPB45_0324 hypothetical protein K07133 K07133; uncharacterized protein
D TOPB45_0329 hypothetical protein K07133 K07133; uncharacterized protein
D TOPB45_1484 FAD-dependent pyridine nucleotide-disulfide oxidoreductase K07137 K07137; uncharacterized protein
D TOPB45_1025 Conserved hypothetical protein CHP01212 K07139 K07139; uncharacterized protein
D TOPB45_1608 protein of unknown function DUF164 K07164 K07164; uncharacterized protein
D TOPB45_0589 UPF0161 protein yidD K08998 K08998; uncharacterized protein
D TOPB45_1176 protein of unknown function DUF151 K08999 K08999; uncharacterized protein
D TOPB45_1198 protein of unknown function DUF763 K09003 K09003; uncharacterized protein
D TOPB45_0601 hypothetical protein K09004 K09004; uncharacterized protein
D TOPB45_1294 protein of unknown function DUF82 K09122 K09122; uncharacterized protein
D TOPB45_1269 UPF0235 protein yggU K09131 K09131; uncharacterized protein
D TOPB45_0135 protein of unknown function DUF364 K09138 K09138; uncharacterized protein
D TOPB45_0736 AMMECR1-domain protein K09141 K09141; uncharacterized protein
D TOPB45_0442 protein of unknown function DUF369 K09143 K09143; uncharacterized protein
D TOPB45_0366 hypothetical protein K09147 K09147; uncharacterized protein
D TOPB45_0862 protein of unknown function DUF1284 K09706 K09706; uncharacterized protein
D TOPB45_1623 ApbE family lipoprotein K09740 K09740; uncharacterized protein
D TOPB45_1361 protein of unknown function DUF342 K09749 K09749; uncharacterized protein
D TOPB45_1078 protein of unknown function DUF503 K09764 K09764; uncharacterized protein
D TOPB45_1190 protein of unknown function DUF343 K09791 K09791; uncharacterized protein
D TOPB45_1397 hypothetical protein K09794 K09794; uncharacterized protein
D TOPB45_1618 UPF0243 zinc-binding protein yacG K09862 K09862; uncharacterized protein
D TOPB45_0256 hypothetical protein K07502 yprB; uncharacterized protein
D TOPB45_0626 protein of unknown function DUF47 K07220 K07220; uncharacterized protein
D TOPB45_1477 protein of unknown function DUF448 K07742 ylxR; uncharacterized protein
!
#
#[ KO | BRITE | KEGG2 | KEGG ]
#Last updated: June 4, 2024