+E Replication protein KO
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DNA Replication Proteins - Amborella trichopoda
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 18439981 origin of replication complex subunit 1A K02603 ORC1; origin recognition complex subunit 1
D 18425067 origin of replication complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D 18443973 origin of replication complex subunit 3 isoform X3 K02605 ORC3; origin recognition complex subunit 3
D 18433842 origin of replication complex subunit 4 isoform X1 K02606 ORC4; origin recognition complex subunit 4
D 18425159 origin of replication complex subunit 5 K02607 ORC5; origin recognition complex subunit 5
D 18446348 origin of replication complex subunit 6 isoform X1 K02608 ORC6; origin recognition complex subunit 6
D 18422807 CDT1-like protein a, chloroplastic isoform X1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 18438414 CDT1-like protein b isoform X1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 18437894 cell division control protein 6 homolog B K02213 CDC6; cell division control protein 6
D 18434542 LOW QUALITY PROTEIN: DNA replication licensing factor MCM2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 18431537 DNA replication licensing factor MCM3 homolog 2 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 18424154 DNA replication licensing factor MCM4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 18438512 DNA replication licensing factor MCM5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 18448940 DNA replication licensing factor MCM6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 18445069 DNA replication licensing factor MCM7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 18424623 cyclin-A3-1 isoform X2 K06627 CCNA; cyclin-A
D 18448952 cyclin-A1-4 K06627 CCNA; cyclin-A
D 18443910 cyclin-A2-4 isoform X1 K06627 CCNA; cyclin-A
D 18438949 cell division control protein 2 homolog A isoform X1 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
D 18436017 cell division control protein 2 homolog A isoform X1 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 18429215 uncharacterized protein LOC18429215 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
C GINS complex
D 18440211 DNA replication complex GINS protein PSF1 isoform X1 K10732 GINS1; GINS complex subunit 1
D 18436466 DNA replication complex GINS protein PSF2 isoform X2 K10733 GINS2; GINS complex subunit 2
D 18447101 DNA replication complex GINS protein PSF3 isoform X2 K10734 GINS3; GINS complex subunit 3
D 18422643 DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 18433997 DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 18445093 BRCT domain-containing protein At4g02110 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 18438029 DNA topoisomerase 2-binding protein 1-A isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 18441904 ATP-dependent DNA helicase Q-like 5 isoform X1 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 18425177 LOW QUALITY PROTEIN: cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 18433069 probable DNA helicase MCM8 isoform X1 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 18423306 probable DNA helicase MCM9 isoform X1 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 18426544 protein MCM10 homolog K10736 MCM10; minichromosome maintenance protein 10
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 18436827 DNA polymerase alpha catalytic subunit isoform X1 K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 18448765 DNA polymerase alpha subunit B isoform X1 K02321 POLA2; DNA polymerase alpha subunit B
D 18428347 DNA primase small subunit isoform X2 K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 18438062 probable DNA primase large subunit isoform X1 K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 18441362 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 18439291 DNA polymerase epsilon subunit B isoform X1 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 18444853 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
C DNA polymerase delta complex
D 18436873 DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 18445437 DNA polymerase delta small subunit K02328 POLD2; DNA polymerase delta subunit 2
D 18425624 uncharacterized protein LOC18425624 isoform X2 K03504 POLD3; DNA polymerase delta subunit 3
D 18422717 DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
C RPA (replication protein A)
D 18443944 replication protein A 70 kDa DNA-binding subunit A K07466 RFA1; replication factor A1
D 18439401 replication protein A 70 kDa DNA-binding subunit A K07466 RFA1; replication factor A1
D 18435757 replication protein A 70 kDa DNA-binding subunit B K07466 RFA1; replication factor A1
D 18433616 replication protein A 32 kDa subunit A K10739 RFA2; replication factor A2
D 105420234 replication protein A 32 kDa subunit A-like K10739 RFA2; replication factor A2
D 110006366 replication protein A 32 kDa subunit A-like K10739 RFA2; replication factor A2
D 18445106 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 18421646 replication factor C subunit 1 isoform X2 K10754 RFC1; replication factor C subunit 1
D 18424681 replication factor C subunit 2 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 18447693 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 18429197 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 18422538 uncharacterized protein LOC18422538 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 18421517 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 18446530 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 18441249 ribonuclease H2 subunit A isoform X2 K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 18435081 ribonuclease H2 subunit B K10744 RNASEH2B; ribonuclease H2 subunit B
D 18443079 ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 18423068 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 18437798 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 18443545 DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 18431337 flap endonuclease 1 isoform X2 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 18435158 exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 18443206 exonuclease 1 isoform X1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 18427928 DNA annealing helicase and endonuclease ZRANB3 isoform X1 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 18428563 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 18423411 uncharacterized protein LOC18423411 isoform X1 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 18436927 DNA (cytosine-5)-methyltransferase 1B K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 18443907 DNA (cytosine-5)-methyltransferase 1 isoform X1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 18439354 DNA (cytosine-5)-methyltransferase CMT3 isoform X1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 18425397 DNA (cytosine-5)-methyltransferase 4 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 18445318 uncharacterized protein LOC18445318 isoform X1 K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
C Prevention of re-replication factors
D 18421708 uncharacterized protein LOC18421708 isoform X1 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 18422044 cyclin-B2-2 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 18424080 G2/mitotic-specific cyclin-2 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 18427131 G2/mitotic-specific cyclin S13-7 K21777 CCNB; G2/mitotic-specific cyclin-B, other
C Telomere proteins
D Shelterin complex
E 18446903 uncharacterized protein LOC18446903 isoform X1 K11111 TERF2; telomeric repeat-binding factor 2
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
E 18435705 CST complex subunit STN1 K23312 STN1; CST complex subunit STN1
E 18431480 CST complex subunit TEN1 K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 18433477 telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Dyskerin complex
E 18421428 putative H/ACA ribonucleoprotein complex subunit 1-like protein 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 18434022 H/ACA ribonucleoprotein complex subunit 2-like protein isoform X1 K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 18434598 H/ACA ribonucleoprotein complex subunit 4 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
E 18995792 H/ACA ribonucleoprotein complex subunit 4 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 18433477 telomerase reverse transcriptase K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 18421525 small nuclear ribonucleoprotein-associated protein B' K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 18447469 small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 18445356 small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 18424057 small nuclear ribonucleoprotein SmD3b isoform X2 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 18443065 small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 18435458 small nuclear ribonucleoprotein E isoform X1 K11097 SNRPE; small nuclear ribonucleoprotein E
E 18437879 probable small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 18441247 probable small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 18424681 replication factor C subunit 2 isoform X1 K10755 RFC2_4; replication factor C subunit 2/4
D 18447693 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 18429197 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 18422538 uncharacterized protein LOC18422538 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
D 18421517 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 18446530 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 18431638 double-strand break repair protein MRE11 isoform X1 K10865 MRE11; double-strand break repair protein MRE11
D 18438248 DNA repair protein RAD50 isoform X1 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 18437555 nijmegen breakage syndrome 1 protein isoform X1 K10867 NBN; nibrin
C Other termination factors
D 18434891 serine/threonine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 18440225 ATP-dependent DNA helicase Q-like SIM isoform X2 K10900 WRN; werner syndrome ATP-dependent helicase [EC:5.6.2.4]
D 18425823 ATP-dependent DNA helicase Q-like 4A isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 18446777 DNA repair endonuclease UVH1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 18429152 DNA repair endonuclease UVH1 isoform X1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 18422814 poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 18445350 poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 18426949 LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase 3 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 18445416 LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase 2-A-like K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 18424381 G patch domain-containing protein 4 isoform X1 K11135 PINX1; Pin2-interacting protein X1
D 18432067 regulator of telomere elongation helicase 1 homolog isoform X1 K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 18441878 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 18446340 uncharacterized protein LOC18446340 isoform X1 K11138 RIF1; telomere-associated protein RIF1
D 18425156 transcription factor Pur-alpha 1 K21772 PURA; transcriptional activator protein Pur-alpha
D 18431621 telomerase Cajal body protein 1 isoform X1 K23314 WRAP53; telomerase Cajal body protein 1
D 18437486 protein SDE2 homolog K25059 SDE2; replication stress response regulator SDE2
D 18447019 protein RTF2 homolog K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 18446014 DNA topoisomerase 1 alpha isoform X1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 18447651 DNA topoisomerase 1 alpha isoform X1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 18428924 DNA topoisomerase 2 isoform X2 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 18424677 DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 18434980 DNA topoisomerase 3-beta K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 18444021 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
D Other elongation factors
E 18447964 DNA polymerase I A, chloroplastic K02335 polA; DNA polymerase I [EC:2.7.7.7]
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
D RFC (replication factor C)
D Other elongation factors
E 18443545 DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 18431337 flap endonuclease 1 isoform X2 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 18428563 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
C 18425241 DNA gyrase subunit A, chloroplastic/mitochondrial isoform X1 K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
C 18440484 DNA gyrase subunit B, chloroplastic/mitochondrial isoform X1 K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
C 105421483 LOW QUALITY PROTEIN: DNA topoisomerase 6 subunit B-like K03167 top6B; DNA topoisomerase VI subunit B [EC:5.6.2.2]
C 18439852 DNA topoisomerase 6 subunit B isoform X2 K03167 top6B; DNA topoisomerase VI subunit B [EC:5.6.2.2]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022