+E Replication protein KO
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DNA Replication Proteins - Bombus impatiens (common eastern bumble bee)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 100742657 origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D 100742462 origin recognition complex subunit 2 isoform X1 K02604 ORC2; origin recognition complex subunit 2
D 100741776 origin recognition complex subunit 3 isoform X1 K02605 ORC3; origin recognition complex subunit 3
D 100747271 origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D 112211994 origin recognition complex subunit 5-like K02607 ORC5; origin recognition complex subunit 5
D 100748058 DNA replication factor Cdt1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 100743178 cell division control protein 6 homolog isoform X1 K02213 CDC6; cell division control protein 6
D 100750209 DNA replication licensing factor Mcm2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 100743805 DNA replication licensing factor Mcm3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 100744910 DNA replication licensing factor MCM4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 100741259 DNA replication licensing factor Mcm5 isoform X1 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 100749435 DNA replication licensing factor Mcm6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 100741429 DNA replication licensing factor Mcm7 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 105680898 cyclin-A2 K06627 CCNA; cyclin-A
D 100743743 G1/S-specific cyclin-E1 K06626 CCNE; G1/S-specific cyclin-E1
D 100744168 cyclin-dependent kinase 2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 100749500 cell division cycle 7-related protein kinase isoform X1 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
C GINS complex
D 100748476 DNA replication complex GINS protein PSF1-like K10732 GINS1; GINS complex subunit 1
D 105680751 probable DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 100744464 DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 100746252 DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 100744381 DNA topoisomerase 2-binding protein 1-A K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 100745722 DNA topoisomerase 2-binding protein 1 isoform X1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 100744596 ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 100742463 cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 100740480 DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 100740653 protein MCM10 homolog K10736 MCM10; minichromosome maintenance protein 10
D 100743136 cyclin-dependent kinase 2-interacting protein K26052 CINP; cyclin-dependent kinase 2-interacting protein
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 100747321 DNA polymerase alpha catalytic subunit isoform X1 K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 100747611 DNA polymerase alpha subunit B isoform X1 K02321 POLA2; DNA polymerase alpha subunit B
D 100740809 DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 100746176 probable DNA primase large subunit K02685 PRI2; DNA primase large subunit
D 100742925 DNA primase large subunit K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 100741328 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 100747562 DNA polymerase epsilon subunit 2 isoform X1 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 100743328 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 100740208 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 100743961 DNA polymerase delta catalytic subunit isoform X2 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 100740047 DNA polymerase delta small subunit-like K02328 POLD2; DNA polymerase delta subunit 2
D 100749399 DNA polymerase delta subunit 2 isoform X1 K02328 POLD2; DNA polymerase delta subunit 2
D 100749133 DNA polymerase delta subunit 3 K03504 POLD3; DNA polymerase delta subunit 3
C DNA polymerase gamma complex (mitochondrial)
D 100744779 DNA polymerase subunit gamma-1, mitochondrial K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 100740089 DNA polymerase subunit gamma-2, mitochondrial isoform X1 K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 100747726 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
D 100747206 replication protein A 32 kDa subunit-like K10739 RFA2; replication factor A2
D 100746970 replication protein A 32 kDa subunit isoform X1 K10739 RFA2; replication factor A2
D 100750109 uncharacterized protein LOC100750109 K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 100741454 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 100749976 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 100741414 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 100743082 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 100741701 replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 100740092 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 100747849 ribonuclease H2 subunit A isoform X1 K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 100741672 ribonuclease H2 subunit B K10744 RNASEH2B; ribonuclease H2 subunit B
D 100743902 ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 100740536 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 100742473 DNA replication ATP-dependent helicase/nuclease DNA2 isoform X2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 100746385 flap endonuclease 1 isoform X1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 100740396 exonuclease 1 isoform X1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 100748010 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 100742770 ATPase family AAA domain-containing protein 5 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 100741065 DNA (cytosine-5)-methyltransferase PliMCI K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 100742803 DNA (cytosine-5)-methyltransferase PliMCI isoform X1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
C Prevention of re-replication factors
D 100743129 geminin isoform X2 K10749 GMNN; geminin
D 105680539 G2/mitotic-specific cyclin-B K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 100745385 G2/mitotic-specific cyclin-B3 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 105680328 uncharacterized protein LOC105680328 K21777 CCNB; G2/mitotic-specific cyclin-B, other
D 100749285 cyclin-dependent kinase 1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
D TERB1-TERB2-MAJIN complex
D CST complex (animals)
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 100742633 telomerase-binding protein EST1A isoform X1 K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 105680753 protein SMG5 K11125 SMG5; protein SMG5
D 100747169 telomerase reverse transcriptase isoform X1 K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Dyskerin complex
E 100747769 H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 100747074 H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 100744635 H/ACA ribonucleoprotein complex subunit 2-like protein K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 100747771 H/ACA ribonucleoprotein complex subunit 3 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 100742337 H/ACA ribonucleoprotein complex subunit 4 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 100747169 telomerase reverse transcriptase isoform X1 K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 100749945 small nuclear ribonucleoprotein-associated protein B isoform X1 K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 100740801 probable small nuclear ribonucleoprotein Sm D1 isoform X1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 100743433 probable small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 100743102 small nuclear ribonucleoprotein Sm D3 K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 100741381 probable small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 100748964 small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 100747800 probable small nuclear ribonucleoprotein G isoform X2 K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 100749976 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 100741414 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 100743082 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D 100741701 replication factor C subunit 5 isoform X1 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 100748898 double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
D 100748279 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 100745699 uncharacterized protein LOC100745699 isoform X1 K10867 NBN; nibrin
C Other termination factors
D 100741124 serine-protein kinase ATM isoform X1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 105680193 Bloom syndrome protein homolog isoform X2 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 100744526 DNA-dependent protein kinase catalytic subunit isoform X1 K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 100741106 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 100740406 poly [ADP-ribose] polymerase isoform X1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 100740200 tankyrase isoform X1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 100743079 G patch domain-containing protein 4 isoform X1 K11135 PINX1; Pin2-interacting protein X1
D 100744569 regulator of telomere elongation helicase 1 homolog K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 100746707 telomere-associated protein RIF1 isoform X1 K11138 RIF1; telomere-associated protein RIF1
D 100744517 ATP-dependent DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 100740146 transcriptional activator protein Pur-beta isoform X1 K21772 PURA; transcriptional activator protein Pur-alpha
D 100746828 telomerase Cajal body protein 1 isoform X1 K23314 WRAP53; telomerase Cajal body protein 1
D 105681060 replication stress response regulator SDE2 K25059 SDE2; replication stress response regulator SDE2
D 100743666 protein RTF2 homolog K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 100742582 DNA topoisomerase I, mitochondrial isoform X1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 100741177 DNA topoisomerase 2 isoform X2 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 100745632 DNA topoisomerase 3-alpha isoform X1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 100750055 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 100746470 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 100740092 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 100740092 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 100742473 DNA replication ATP-dependent helicase/nuclease DNA2 isoform X2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 100746385 flap endonuclease 1 isoform X1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 100748010 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022