+C Two-component system KO
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Two-Component System - Clostridium beijerinckii NCIMB 8052
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C Cbei_1126 multi-sensor signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C Cbei_2435 PAS/PAC sensor signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C Cbei_0535 integral membrane sensor signal transduction histidine kinase K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C Cbei_1125 two component transcriptional regulator, winged helix family K07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP
C Cbei_3359 two component transcriptional regulator, winged helix family K07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP
C Cbei_1805 two component transcriptional regulator, winged helix family K07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
B EnvZ-OmpR (osmotic stress response)
B RstB-RstA
B CpxA-CpxR (envelope stress response)
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
B BaeS-BaeR (envelope stress response)
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
B QseC-QseB (quorum sensing)
B KdpD-KdpE (potassium transport)
C Cbei_2027 osmosensitive K+ channel signal transduction histidine kinase K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C Cbei_2028 two component transcriptional regulator, winged helix family K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
B TctE-TctD (tricarboxylic acid transport)
B ResE-ResD (aerobic and anaerobic respiration)
C Cbei_2400 two component transcriptional regulator, winged helix family K07775 resD; two-component system, OmpR family, response regulator ResD
C Cbei_0083 two component transcriptional regulator, winged helix family K07775 resD; two-component system, OmpR family, response regulator ResD
B VicK-VicR (cell wall metabolism)
C Cbei_3169 multi-sensor signal transduction histidine kinase K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3]
C Cbei_4625 two component transcriptional regulator, winged helix family K07668 vicR; two-component system, OmpR family, response regulator VicR
C Cbei_2845 two component transcriptional regulator, winged helix family K07668 vicR; two-component system, OmpR family, response regulator VicR
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
C Cbei_0043 integral membrane sensor signal transduction histidine kinase K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3]
C Cbei_0042 two component transcriptional regulator, winged helix family K14983 ciaR; two-component system, OmpR family, response regulator CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
C Cbei_4102 integral membrane sensor signal transduction histidine kinase K18345 vanSB; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3]
C Cbei_1732 integral membrane sensor signal transduction histidine kinase K18345 vanSB; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3]
C Cbei_2399 integral membrane sensor signal transduction histidine kinase K18345 vanSB; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3]
B VanS-VanR (VanE type vancomycin resistance)
C Cbei_2250 histidine kinase K18350 vanSC; two-component system, OmpR family, sensor histidine kinase VanS [EC:2.7.13.3]
C Cbei_3775 two component transcriptional regulator, winged helix family K18349 vanRC; two-component system, OmpR family, response regulator VanR
C Cbei_2117 two component transcriptional regulator, winged helix family K18349 vanRC; two-component system, OmpR family, response regulator VanR
C Cbei_2249 two component transcriptional regulator, winged helix family K18349 vanRC; two-component system, OmpR family, response regulator VanR
C Cbei_0589 two component transcriptional regulator, winged helix family K18349 vanRC; two-component system, OmpR family, response regulator VanR
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
C Cbei_3564 histidine kinase K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3]
C Cbei_3565 two component transcriptional regulator, winged helix family K18941 arlR; two-component system, OmpR family, response regulator ArlR
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
C Cbei_3321 integral membrane sensor signal transduction histidine kinase K20487 nisK; two-component system, OmpR family, lantibiotic biosynthesis sensor histidine kinase NisK/SpaK [EC:2.7.13.3]
C Cbei_3322 two component transcriptional regulator, winged helix family K20488 nisR; two-component system, OmpR family, lantibiotic biosynthesis response regulator NisR/SpaR
B Unclassified
C Cbei_4495 integral membrane sensor signal transduction histidine kinase K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C Cbei_4496 two component transcriptional regulator, winged helix family K02483 K02483; two-component system, OmpR family, response regulator
C Cbei_2474 two component transcriptional regulator, winged helix family K02483 K02483; two-component system, OmpR family, response regulator
C Cbei_0534 two component transcriptional regulator, winged helix family K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
B NarQ-NarP (nitrate respiration)
B UhpB-UhpA (hexose phosphates uptake)
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
B BarA-UvrY (central carbon metabolism)
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
B Unclassified
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
C Cbei_1712 response regulator receiver protein K07699 spo0A; two-component system, response regulator, stage 0 sporulation protein A
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ACitB family
B CitA-CitB (citrate fermentation)
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
C Cbei_4005 signal transduction histidine kinase regulating citrate/malate metabolism K02476 K02476; two-component system, CitB family, sensor kinase [EC:2.7.13.3]
C Cbei_4004 response regulator receiver K02475 K02475; two-component system, CitB family, response regulator
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
C Cbei_4579 sensor histidine kinase-like protein K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
C Cbei_0659 signal transduction histidine kinase regulating citrate/malate metabolism K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
C Cbei_3923 integral membrane sensor signal transduction histidine kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3]
C Cbei_4580 two component transcriptional regulator, LytTR family K07707 agrA; two-component system, LytTR family, response regulator AgrA
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
C Cbei_0555 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C Cbei_4052 signal transduction histidine kinase, LytS K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C Cbei_1480 two component transcriptional regulator, LytTR family K02477 K02477; two-component system, LytTR family, response regulator
C Cbei_0556 two component transcriptional regulator, LytTR family K02477 K02477; two-component system, LytTR family, response regulator
C Cbei_3967 two component transcriptional regulator, LytTR family K02477 K02477; two-component system, LytTR family, response regulator
C Cbei_3654 response regulator receiver protein K02477 K02477; two-component system, LytTR family, response regulator
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
B AtoS-AtoC (cPHB biosynthesis)
C Cbei_3818 signal transduction histidine kinase, nitrogen specific, NtrB K07710 atoS; two-component system, NtrC family, sensor histidine kinase AtoS [EC:2.7.13.3]
C Cbei_3816 two component, sigma54 specific, transcriptional regulator, Fis family K07714 atoC; two-component system, NtrC family, response regulator AtoC
B PilS-PilR (type 4 fimbriae synthesis)
B GlrK-GlrR (amino sugar metabolism)
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
C Cbei_2726 response regulator receiver protein K19641 hupR; two-component system, NtrC family, response regulator HupR/HoxA
B Unclassified
C Cbei_4485 multi-sensor signal transduction histidine kinase K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
C Cbei_2725 response regulator receiver sensor signal transduction histidine kinase K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
C Cbei_2728 PAS/PAC sensor signal transduction histidine kinase K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
C Cbei_3469 histidine kinase K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
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ACheA family
B CheA-CheYBV (chemotaxis)
C Cbei_4307 CheA signal transduction histidine kinase K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C Cbei_4183 CheA signal transduction histidine kinase K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C Cbei_4829 CheA signal transduction histidine kinase K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C Cbei_4019 CheA signal transduction histidine kinase K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C Cbei_4015 response regulator receiver protein K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C Cbei_4305 response regulator receiver protein K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C Cbei_4819 response regulator receiver protein K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C Cbei_4020 response regulator receiver protein K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C Cbei_4824 response regulator receiver protein K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C Cbei_2516 response regulator receiver protein K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C Cbei_0537 response regulator receiver protein K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C Cbei_4826 response regulator receiver modulated CheB methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C Cbei_4309 response regulator receiver modulated CheB methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C Cbei_4180 response regulator receiver modulated CheB methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C Cbei_0755 putative CheW protein K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
B ChpA-ChpB/PilGH (chemosensory)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
B AauS-AauR (acidic amino acids utilization)
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
C Cbei_4175 signal transduction histidine kinase regulating citrate/malate metabolism K07717 glnK; two-component system, sensor histidine kinase GlnK [EC:2.7.13.3]
C Cbei_4174 response regulator receiver K07719 glnL; two-component system, response regulator GlnL
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
C Cbei_4430 multi-sensor signal transduction histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C Cbei_4458 histidine kinase internal region K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C Cbei_2898 histidine kinase internal region K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C Cbei_4963 integral membrane sensor signal transduction histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C Cbei_1382 histidine kinase internal region K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C Cbei_0768 histidine kinase internal region K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C Cbei_1234 histidine kinase internal region K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C Cbei_4677 integral membrane sensor signal transduction histidine kinase K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C Cbei_3502 histidine kinase internal region K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3]
C Cbei_1235 response regulator receiver protein K07720 yesN; two-component system, response regulator YesN
C Cbei_4464 response regulator receiver protein K07720 yesN; two-component system, response regulator YesN
C Cbei_2379 response regulator receiver protein K07720 yesN; two-component system, response regulator YesN
C Cbei_0767 response regulator receiver protein K07720 yesN; two-component system, response regulator YesN
C Cbei_1381 response regulator receiver protein K07720 yesN; two-component system, response regulator YesN
C Cbei_4051 response regulator receiver protein K07720 yesN; two-component system, response regulator YesN
C Cbei_4676 response regulator receiver protein K07720 yesN; two-component system, response regulator YesN
C Cbei_4962 response regulator receiver protein K07720 yesN; two-component system, response regulator YesN
C Cbei_4431 response regulator receiver protein K07720 yesN; two-component system, response regulator YesN
C Cbei_3503 response regulator receiver protein K07720 yesN; two-component system, response regulator YesN
C Cbei_2897 response regulator receiver protein K07720 yesN; two-component system, response regulator YesN
B CikA
B RegB-RegA (redox response)
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
C Cbei_0710 histidine kinase K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]
C Cbei_4016 histidine kinase K20974 K20974; two-component system, sensor histidine kinase [EC:2.7.13.3]
B PdtaS-PdtaR
C Cbei_4205 response regulator receiver and ANTAR domain protein K22010 pdtaR; two-component system, response regulator PdtaR
B NasS-NasT
B Unclassified
C Cbei_2171 signal transduction histidine kinase, LytS K19694 chiS; two-component system, sensor histidine kinase ChiS
C Cbei_3405 response regulator receiver sensor signal transduction histidine kinase K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
C Cbei_2515 multi-sensor hybrid histidine kinase K11527 K11527; two-component system, sensor histidine kinase and response regulator [EC:2.7.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023