+E Ubiquitin system KO
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Ubiquitin System - Cryptococcus gattii
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AUbiquitins and ubiquitin-like proteins
B Ubiquitins
C CGB_B3800W ubiquitin-carboxy extension protein fusion K02927 RP-L40e; ubiquitin-large subunit ribosomal protein L40e
C CGB_D5610C ribosomal chaperone K02977 RP-S27Ae; ubiquitin-small subunit ribosomal protein S27Ae
B Ubiquitin-like proteins (UBLs)
C CGB_C6550C ribosomal chaperone K12158 NEDD8; ubiquitin-like protein Nedd8
C CGB_A9330C microtubule binding protein K08341 GABARAP; GABA(A) receptor-associated protein
C CGB_E4120C hypothetical protein K08336 ATG12; ubiquitin-like protein ATG12
C CGB_D1690W hypothetical protein K12161 URM1; ubiquitin related modifier 1
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AUbiquitin-activating enzymes (E1)
B Ubiquitin activating enzyme
C CGB_B1450C ubiquitin activating enzyme K03178 UBE1; ubiquitin-activating enzyme E1 [EC:6.2.1.45]
B UBL-activating enzymes
C CGB_N1110W SUMO activating enzyme K10684 UBLE1A; ubiquitin-like 1-activating enzyme E1 A [EC:6.2.1.45]
C CGB_F5510C ubiquitin activating enzyme E1 K10685 UBLE1B; ubiquitin-like 1-activating enzyme E1 B [EC:6.2.1.45]
C CGB_C3070C NEDD8 activating enzyme K10686 UBA3; NEDD8-activating enzyme E1 [EC:6.2.1.64]
C CGB_M3270C ubiquitin-activating enzyme(E1) subunit;UlaA K04532 NAE1; NEDD8-activating enzyme E1 regulatory subunit
C CGB_D3370C URM1 activating enzyme K11996 MOCS3; adenylyltransferase and sulfurtransferase [EC:2.7.7.80 2.8.1.11]
C CGB_H0560C ubiquitin-like conjugating enzyme K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
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AUbiquitin-conjugating enzymes (E2)
B Ubiquitin-conjugating enzymes
C CGB_A9410W ubiquitin-conjugating enzyme E2-17 kDa K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
C CGB_F3010W ubiquitin-conjugating enzyme E2-16 kDa K06689 UBE2D; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]
C CGB_F0550W ubiquitin conjugating enzyme K10575 UBE2G1; ubiquitin-conjugating enzyme E2 G1 [EC:2.3.2.23]
C CGB_E3710W ubiquitin conjugating enzyme K04555 UBE2G2; ubiquitin-conjugating enzyme E2 G2 [EC:2.3.2.23]
C CGB_D9290W ubiquitin-conjugating enzyme K10576 UBE2H; ubiquitin-conjugating enzyme E2 H [EC:2.3.2.23]
C CGB_E4270W ubiquitin conjugating enzyme K10578 UBE2J1; ubiquitin-conjugating enzyme E2 J1 [EC:2.3.2.23]
C CGB_F3660C ubiquitin-conjugating enzyme E2-28.4KD K04554 UBE2J2; ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23]
C CGB_C7480C ubiquitin-conjugating enzyme E2-24 kDa K04649 UBE2K; ubiquitin-conjugating enzyme (huntingtin interacting protein 2) [EC:2.3.2.23]
C CGB_E5170C hypothetical protein K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C CGB_F5070W hypothetical protein K10581 UBE2O; ubiquitin-conjugating enzyme E2 O [EC:2.3.2.24]
C CGB_D6710W hypothetical protein K10583 UBE2S; ubiquitin-conjugating enzyme E2 S [EC:2.3.2.23]
C CGB_E5520C hypothetical protein K10688 UBE2W; ubiquitin-conjugating enzyme E2 W [EC:2.3.2.23 2.3.2.25]
B UBL-conjugating enzymes
C CGB_H3230W ubiquitin-conjugating enzyme K10577 UBE2I; ubiquitin-conjugating enzyme E2 I
C CGB_D8540C E2 ubiquitin-conjugating enzyme K10579 UBE2M; ubiquitin-conjugating enzyme E2 M [EC:2.3.2.34]
C CGB_K4160W autophagy-related protein K08343 ATG3; ubiquitin-like-conjugating enzyme ATG3
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AUbiquitin ligases (E3)
B HECT type E3
C CGB_D8010W hypothetical protein K10589 UBE3C; ubiquitin-protein ligase E3 C [EC:2.3.2.26]
C CGB_C2520W hypothetical protein K20803 UBE3D; ubiquitin-protein ligase E3 D [EC:2.3.2.26]
C CGB_D6390W ubiquitin fusion degradation protein K10590 TRIP12; E3 ubiquitin-protein ligase TRIP12 [EC:2.3.2.26]
C CGB_H0270C ubiquitin-protein ligase K10591 NEDD4; E3 ubiquitin-protein ligase NEDD4 [EC:2.3.2.26]
C CGB_H1790W ubiquitin-protein ligase K10592 HUWE1; E3 ubiquitin-protein ligase HUWE1 [EC:2.3.2.26]
C HECT type E3 associated proteins
B U-box type E3
C CGB_D3030C ubiquitin chain assembly factor; Ufd2p K10597 UBE4B; ubiquitin conjugation factor E4 B [EC:2.3.2.27]
C CGB_D9590W hypothetical protein K10598 PPIL2; peptidyl-prolyl cis-trans isomerase-like 2 [EC:5.2.1.8]
C CGB_C3450C nuclear matrix protein NMP200 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
B Single Ring-finger type E3
C BRE1 proteins
D CGB_H3480C hypothetical protein K10696 BRE1; E3 ubiquitin-protein ligase BRE1 [EC:2.3.2.27]
C CBL proteins
C SINA (Seven in absentia) proteins
C Ligand of Numb proteins
C March proteins
D CGB_F1450C hypothetical protein K10661 MARCH6; E3 ubiquitin-protein ligase MARCH6 [EC:2.3.2.27]
C MDM2/MDM4 proteins
C NFX1 proteins
D CGB_C8380W transcriptional repressor NF-X1 (Nuclear transcription factor, X box-binding, 1) K12236 NFX1; transcriptional repressor NF-X1
C Pellino proteins
C Peripheral membrane proteins
D CGB_L2520W peroxisome assembly protein per8 (peroxin-10) K13346 PEX10; peroxin-10
D CGB_D0040W hypothetical protein K13345 PEX12; peroxin-12
D CGB_B1790W peroxisome assembly protein K06664 PEX2; peroxin-2
C RBR proteins
D CGB_H5260C ariadne-1 protein-like protein K11968 ARIH1; ariadne-1 [EC:2.3.2.31]
D CGB_C3580C regulation of translational termination-related protein K11971 RNF14; E3 ubiquitin-protein ligase RNF14 [EC:2.3.2.31]
D CGB_B6590W hypothetical protein K20804 RNF34; E3 ubiquitin-protein ligase RNF34 [EC:2.3.2.31]
D CGB_L1400C hypothetical protein K11976 RNF216; E3 ubiquitin-protein ligase RNF216 [EC:2.3.2.31]
C TRAF proteins
C TRIM/RBCC proteins
C UBR box proteins
D CGB_E4700W ubiquitin-protein ligase K10625 UBR1; E3 ubiquitin-protein ligase UBR1 [EC:2.3.2.27]
D CGB_B5530W hypothetical protein K11979 UBR7; E3 ubiquitin-protein ligase UBR7 [EC:2.3.2.27]
C ATL proteins
C Other single Ring-finger type E3
D CGB_G0570C RING finger protein K10632 BRAP; BRCA1-associated protein [EC:2.3.2.27]
D CGB_A3070W transcriptional repressor K10643 CNOT4; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
D CGB_E4250W hypothetical protein K22377 LTN1; E3 ubiquitin-protein ligase listerin [EC:2.3.2.27]
D CGB_L2250C hypothetical protein K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D CGB_E4220W hypothetical protein K11982 RNF115_126; E3 ubiquitin-protein ligase RNF115/126 [EC:2.3.2.27]
D CGB_H4370C hypothetical protein K11984 SART1; U4/U6.U5 tri-snRNP-associated protein 1
D CGB_D3680W hypothetical protein K15710 SHPRH; E3 ubiquitin-protein ligase SHPRH [EC:5.6.2.- 2.3.2.27]
D CGB_D1820C SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 3 K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D CGB_I2280C DNA repair protein RAD5 K15711 SMARCA3; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A3 [EC:5.6.2. 2.3.2.27]
D CGB_L1340W hypothetical protein K10601 SYVN1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27]
D CGB_G6030C cytoplasm protein K22381 ZNF598; E3 ubiquitin-protein ligase ZNF598 [EC:2.3.2.27]
D CGB_A9660W RING finger ubiquitin ligase K23788 TUL1; transmembrane E3 ubiquitin-protein ligase [EC:2.3.2.27]
D CGB_G4010C cytoplasm protein K23787 DMA1_2; E3 ubiquitin-protein ligase DMA1/2 [EC:2.3.2.27]
B Atypical E3
C CGB_H0320C DNA repair-related protein K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
B UBL E3 ligases
C CGB_A3220W ubiquitin-protein ligase K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
C CGB_M3310C chromosome condensation-related protein K04706 PIAS1; E3 SUMO-protein ligase PIAS1 [EC:2.3.2.-]
C CGB_D5230C hypothetical protein K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
C CGB_D0420C hypothetical protein K25662 RNF212; E3 SUMO-protein ligase RNF212 [EC:2.3.2.-]
C CGB_I1610C hypothetical protein K17822 DCUN1D1_2; DCN1-like protein 1/2
B Multi subunit Ring-finger type E3
C SCF complex
D Ring finger protein
E CGB_A3220W ubiquitin-protein ligase K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
E CGB_N1540W cullin; Cdc53p K03347 CUL1; cullin 1
D Adaptor protein
E CGB_A9450C ubiquitin-protein ligase K03094 SKP1; S-phase kinase-associated protein 1
D Target recognizing subunit (F-box)
E CGB_N1480C F-box and WD40 domain protein K03362 FBXW1_11; F-box and WD-40 domain protein 1/11
E CGB_F4020C F-box protein; Met30p K10259 MET30; F-box and WD-40 domain protein MET30
E CGB_A7520W ubiquitin-protein ligase K03361 CDC4; F-box and WD-40 domain protein CDC4
E CGB_I4340C F-box/WD-repeat protein 7 K03361 CDC4; F-box and WD-40 domain protein CDC4
E CGB_N3320W hypothetical protein K10268 FBXL2_20; F-box and leucine-rich repeat protein 2/20
E CGB_G6080W hypothetical protein K10276 FBXL10_11; F-box and leucine-rich repeat protein 10/11 [EC:1.14.11.27]
E CGB_I4220C ubiquitin-protein ligase K03360 GRR1; F-box and leucine-rich repeat protein GRR1
E CGB_H1490W F-box domain-containing protein K10295 FBXO9; F-box protein 9
E CGB_H3110C F-box protein pof6 K15071 RCY1; recyclin-1
E CGB_A2420W hypothetical protein K15072 SAF1; SCF-associated factor 1
C Cul2 complex
D Ring finger protein
E CGB_A3220W ubiquitin-protein ligase K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adoptor protein
E CGB_B3080W transcriptional elongation regulator K03872 ELOC; elongin-C
D Target recognizing subunit
C Cul3 complex
D Ring finger protein
E CGB_A3220W ubiquitin-protein ligase K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
E CGB_G0120W ubiquitin-protein ligase K03869 CUL3; cullin 3
D Adoptor and target recognizing subunit (BTB)
C Cul4 complex
D Ring finger protein
E CGB_A3220W ubiquitin-protein ligase K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
E CGB_G0470C ubiquitin-protein ligase K10609 CUL4; cullin 4
D Adoptor protein
E CGB_G1120W hypothetical protein K10610 DDB1; DNA damage-binding protein 1
D Target recognizing subunit (DCAF)
E CGB_I4190W hypothetical protein K11790 DTL; denticleless
E CGB_I4180C hypothetical protein K11790 DTL; denticleless
E CGB_A5010C hypothetical protein K11799 DCAF4; DDB1- and CUL4-associated factor 4
E CGB_F4510W transparent testa glabra 1 protein K11805 DCAF7; DDB1- and CUL4-associated factor 7
E CGB_H5660W hypothetical protein K11807 WDTC1; WD and tetratricopeptide repeats protein 1
E CGB_A5390W WD-repeat protein K11801 DCAF11; DDB1- and CUL4-associated factor 11
E CGB_A6400C snoRNA binding protein K11806 DCAF13; DDB1- and CUL4-associated factor 13
E CGB_C1290W negative regulation of gluconeogenesis-related protein K22382 WDR26; WD repeat-containing protein 26
E CGB_J2040W transcription factor K24752 WDR70; WD repeat-containing protein 70
E CGB_H5160C hypothetical protein K24755 WDR76; WD repeat-containing protein 76
C Cul5 complex
D Ring finger protein
D Cullin
D Adoptor protein
E CGB_B3080W transcriptional elongation regulator K03872 ELOC; elongin-C
D Target recognizing subunit
C Cul7 complex
D Ring finger protein
E CGB_A3220W ubiquitin-protein ligase K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adaptor protein
E CGB_A9450C ubiquitin-protein ligase K03094 SKP1; S-phase kinase-associated protein 1
D Target recognizing subunit
C Cul8 complex
D Ring finger protein
E CGB_A3220W ubiquitin-protein ligase K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adaptor protein
D Target recognizing subunit
C Cul9 complex
D Ring finger protein
E CGB_A3220W ubiquitin-protein ligase K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
C APC/C
D Ring finger protein
E CGB_A4310C ubiquitin-protein ligase K03358 APC11; anaphase-promoting complex subunit 11
D Cullin
E CGB_N3430C ubiquitin-protein ligase K03349 APC2; anaphase-promoting complex subunit 2
D Target recognizing subunit
E CGB_H5680W activator of the anaphase-promoting complex/cyclosome (APC/C); Cdh1p K03363 CDC20; cell division cycle 20, cofactor of APC complex
E CGB_G1290C APC/C activator protein CDC20 (Cell division control protein 20) K03364 CDH1; cell division cycle 20-like protein 1, cofactor of APC complex
D Other subunits
E CGB_E4590C negative regulator of mitosis K03348 APC1; anaphase-promoting complex subunit 1
E CGB_B3520W ubiquitin-protein ligase K03350 APC3; anaphase-promoting complex subunit 3
E CGB_C2270W hypothetical protein K03352 APC5; anaphase-promoting complex subunit 5
E CGB_E5110C cell division control protein 16 K03353 APC6; anaphase-promoting complex subunit 6
E CGB_C8300W cell division control protein 23 K03355 APC8; anaphase-promoting complex subunit 8
E CGB_F3450W hypothetical protein K03357 APC10; anaphase-promoting complex subunit 10
C BRCC complex
D CGB_G2270W hypothetical protein K08775 BRCA2; breast cancer 2 susceptibility protein
D CGB_A8080W recombinase K04482 RAD51; DNA repair protein RAD51
C KPC complex
C LUBAC complex
C CTLH complex
D CGB_D7670W negative regulation of gluconeogenesis-related protein K23333 RMND5; E3 ubiquitin-protein transferase RMND5 [EC:2.3.2.27]
D CGB_I2370C endosome protein K23334 RANBP9_10; Ran-binding protein 9/10
D CGB_I1020C protein BSP2 K23336 ARMC8; armadillo repeat-containing protein 8
D CGB_B2090C negative regulation of gluconeogenesis-related protein K18624 MAEA; macrophage erythroblast attacher
D CGB_L0480C hypothetical protein K23335 GID4; glucose-induced degradation protein 4
D CGB_C9260W hypothetical protein K23338 GID8; glucose-induced degradation protein 8
D CGB_C1290W negative regulation of gluconeogenesis-related protein K22382 WDR26; WD repeat-containing protein 26
C ERAD complex
C LMBR1L-GP78-UBAC2 complex
D CGB_B6280C hypothetical protein K25216 UBAC2; ubiquitin-associated domain-containing protein 2
C SLX5-SLX8 complex
C Multi subunit type E3 associated proteins
D CGB_K3130W TIP120-family protein TIP120B K17263 CAND1; cullin-associated NEDD8-dissociated protein 1
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ADeubiquitinating enzyme (DUB)
B Ubiquitin-specific proteases (UBPs)
C UCH
D CGB_B2080W carboxyl-terminal proteinase K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
D CGB_D3400W ubiquitin-specific protease K05610 UCHL5; ubiquitin carboxyl-terminal hydrolase L5 [EC:3.4.19.12]
C UBP/USP
D CGB_G1380C ubiquitin carboxyl-terminal hydrolase 12 K11835 USP4_11; ubiquitin carboxyl-terminal hydrolase 4/11 [EC:3.4.19.12]
D CGB_F3130C ubiquitin carboxyl-terminal hydrolase 14 K11836 USP5_13; ubiquitin carboxyl-terminal hydrolase 5/13 [EC:3.4.19.12]
D CGB_L3600C ubiquitin carboxyl-terminal hydrolase 5 K11838 USP7; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]
D CGB_A8460W ubiquitin-specific protease K11839 USP8; ubiquitin carboxyl-terminal hydrolase 8 [EC:3.4.19.12]
D CGB_K4390W ubiquitin-specific protease K11841 USP10; ubiquitin carboxyl-terminal hydrolase 10 [EC:3.4.19.12]
D CGB_G0160W ubiquitin carboxyl-terminal hydrolase 6 K11843 USP14; ubiquitin carboxyl-terminal hydrolase 14 [EC:3.4.19.12]
D CGB_A2500W hypothetical protein K11844 USP16_45; ubiquitin carboxyl-terminal hydrolase 16/45 [EC:3.4.19.12]
D CGB_F1430C ubiquitin specific protease K11366 USP22_27_51; ubiquitin carboxyl-terminal hydrolase 22/27/51 [EC:3.4.19.12]
D CGB_B2400W ubiquitin carboxyl-terminal hydrolase 2 K11849 USP25; ubiquitin carboxyl-terminal hydrolase 25 [EC:3.4.19.12]
D CGB_A4490C hypothetical protein K11855 USP36_42; ubiquitin carboxyl-terminal hydrolase 36/42 [EC:3.4.19.12]
D CGB_H1240W hypothetical protein K11858 USP48; ubiquitin carboxyl-terminal hydrolase 48 [EC:3.4.19.12]
D CGB_B2160W hypothetical protein K11870 UBP1; ubiquitin carboxyl-terminal hydrolase 1 [EC:3.4.19.12]
D CGB_E2120W ubiquitin thiolesterase 9 K11872 UBP9_13; ubiquitin carboxyl-terminal hydrolase 9/13 [EC:3.4.19.12]
C OTU
D CGB_H1460W hypothetical protein K09602 OTUB1; ubiquitin thioesterase protein OTUB1 [EC:3.4.19.12]
D CGB_C4070W hypothetical protein K13717 OTUD3; OTU domain-containing protein 3 [EC:3.4.19.12]
D CGB_K0210C hypothetical protein K18342 OTUD6; OTU domain-containing protein 6 [EC:3.4.19.12]
C MJD
D CGB_H4540W ataxin-3 K11863 ATXN3; Ataxin-3 [EC:3.4.22.-]
C MINDY
C JAMM
D CGB_B2480C metalloprotease subunit of the 19S regulatory particle of the 26S proteasome lid; Rpn11p K03030 PSMD14; 26S proteasome regulatory subunit N11
C PPPDE
C ZUFSP
C BRISC complex
B UBL-specific proteases (ULPs)
C CGB_J1270W hypothetical protein K08592 SENP1; sentrin-specific protease 1 [EC:3.4.22.68]
C CGB_J1600C peptidase K08595 SENP6; sentrin-specific protease 6 [EC:3.4.22.68]
C CGB_B2080W carboxyl-terminal proteinase K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
C CGB_K2380C hypothetical protein K22762 DESI1; desumoylating isopeptidase 1 [EC:3.4.-.-]
C COP9 signalosome (CSN) complex
D CGB_E0430C cop9 signalosome complex subunit 1 K12175 GPS1; COP9 signalosome complex subunit 1
D CGB_D4270C COP9 signalosome complex subunit 2 K12176 COPS2; COP9 signalosome complex subunit 2
D CGB_L3550W hypothetical protein K12177 COPS3; COP9 signalosome complex subunit 3
D CGB_G0590W COP9 signalosome complex subunit 4 K12178 COPS4; COP9 signalosome complex subunit 4
D CGB_I3270C COP9 signalosome complex subunit 5a K09613 COPS5; COP9 signalosome complex subunit 5 [EC:3.4.-.-]
D CGB_F2100C COP9 complex subunit 6 K12179 COPS6; COP9 signalosome complex subunit 6
D CGB_H5080W hypothetical protein K12180 COPS7; COP9 signalosome complex subunit 7
D CGB_D9130W adaptation to pheromone during conjugation with cellular fusion-related protein K24364 CSN12; COP9 signalosome complex subunit 12
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: May 1, 2024