+C Two-component system KO
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Two-Component System - Cupriavidus necator N-1
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C CNE_1c23470 phoR; phosphate regulon sensor protein PhoR K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C CNE_1c23480 phoB; phosphate regulontranscriptional regulatory protein PhoB K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
C CNE_BB1p04450 response regulator receiver protein K07658 phoB1; two-component system, OmpR family, alkaline phosphatase synthesis response regulator PhoP
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
B EnvZ-OmpR (osmotic stress response)
C CNE_1c06130 envZ1; osmolarity sensor protein EnvZ K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C CNE_1c14890 envZ2; osmolarity sensor protein EnvZ K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C CNE_1c06120 ompR1; transcriptional regulatory protein OmpR K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
C CNE_1c14900 ompR2; transcriptional regulatory protein OmpR K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
B CpxA-CpxR (envelope stress response)
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
C CNE_1c03060 creC; sensor protein CreC K07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3]
C CNE_1c03070 creB; transcriptional regulatory protein CreB K07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB
B BaeS-BaeR (envelope stress response)
B BasS-BasR (antimicrobial peptide resistance)
B CusS-CusR (copper tolerance)
C CNE_2c21720 cusS; sensor kinase CusS K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C CNE_2c16390 hypothetical protein K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C CNE_2c21710 copR; response regulator of copper response OmpR family K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
C CNE_2c16400 response regulator OmpR family K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
B QseC-QseB (quorum sensing)
C CNE_1c14560 qseC2; sensor protein QseC K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C CNE_1c14550 response regulator OmpR family K07666 qseB; two-component system, OmpR family, response regulator QseB
B KdpD-KdpE (potassium transport)
C CNE_1c24830 kdpD; osmosensitive K+ channel histidine kinase KdpD K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C CNE_2c08500 kdpD; osmosensitive K+ channel histidine kinase KdpD K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C CNE_1c24820 kdpE; KDP operontranscriptional regulatory protein KdpE K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
C CNE_2c08490 transcriptional regulator OmpR family K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
B TctE-TctD (tricarboxylic acid transport)
C CNE_1c22900 qseC3; sensor protein QseC K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]
C CNE_1c36780 rssA; swarming motility regulation sensor protein RssA K07649 tctE; two-component system, OmpR family, sensor histidine kinase TctE [EC:2.7.13.3]
C CNE_1c22890 tctD2; transcriptional regulatory protein TctD K07774 tctD; two-component system, OmpR family, response regulator TctD
C CNE_1c36790 tctD3; transcriptional regulatory protein TctD K07774 tctD; two-component system, OmpR family, response regulator TctD
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C CNE_2c24720 signal transduction histidine kinase K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C CNE_2c12160 response regulator OmpR family K02483 K02483; two-component system, OmpR family, response regulator
C CNE_1c35660 ompR3; transcriptional regulatory protein OmpR K02483 K02483; two-component system, OmpR family, response regulator
C CNE_2c17280 response regulator OmpR family K02483 K02483; two-component system, OmpR family, response regulator
C CNE_1c05650 tctD1; transcriptional regulatory protein TctD K02483 K02483; two-component system, OmpR family, response regulator
C CNE_2c24730 response regulator OmpR family K02483 K02483; two-component system, OmpR family, response regulator
C CNE_1c01450 response regulator K02483 K02483; two-component system, OmpR family, response regulator
C CNE_1c36320 response regulator CheY family K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
C CNE_2c22980 narX; signal transduction histidine kinase nitrate/nitrite-specific K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3]
C CNE_2c22990 response regulator NarL family K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
B NarQ-NarP (nitrate respiration)
B UhpB-UhpA (hexose phosphates uptake)
C CNE_1c07920 degS; sensor protein DegS K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
C CNE_2c02950 rcsC1; sensor protein RcsC K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3]
C CNE_2c02940 two componenttranscriptional regulator LuxR family K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
C CNE_1c17240 two componenttranscriptional regulator LuxR family K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
C CNE_2c19370 rcsB; capsular synthesis regulator component B K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
C CNE_2c20350 response regulator NarL family K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
B BarA-UvrY (central carbon metabolism)
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
C CNE_2c01090 response regulator NarL family K07690 evgA; two-component system, NarL family, response regulator EvgA
C CNE_1c05580 response regulator NarL family K07688 fimZ; two-component system, NarL family, response regulator, fimbrial Z protein, FimZ
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
B Unclassified
C CNE_1c36610 signal transduction histidine kinase K02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3]
C CNE_BB1p13560 hypothetical protein K02480 K02480; two-component system, NarL family, sensor kinase [EC:2.7.13.3]
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
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ACitB family
B CitA-CitB (citrate fermentation)
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
C CNE_1c22430 ntrB; nitrogen regulation protein NtrB K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]
C CNE_1c22420 ntrC; response regulator nitrogen regulation protein NtrC K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
B NtrY-NtrX (nitrogen regulation)
C CNE_1c36460 ntrY; nitrogen regulation protein NtrY K13598 ntrY; two-component system, NtrC family, nitrogen regulation sensor histidine kinase NtrY [EC:2.7.13.3]
C CNE_1c36450 ntrX; response regulator NtrX K13599 ntrX; two-component system, NtrC family, nitrogen regulation response regulator NtrX
B HydH-HydG (metal tolerance)
C CNE_2c23140 response regulator containing sigma54 activator and Fis-type DNA-binding domains K07713 zraR; two-component system, NtrC family, response regulator HydG
C CNE_2c23150 response regulator-like protein containing sigma54 activator and Fis-type DNA-binding domains K07713 zraR; two-component system, NtrC family, response regulator HydG
B AtoS-AtoC (cPHB biosynthesis)
B PilS-PilR (type 4 fimbriae synthesis)
C CNE_1c31710 pilS; sensor protein PilS K02668 pilS; two-component system, NtrC family, sensor histidine kinase PilS [EC:2.7.13.3]
C CNE_1c31700 pilR; type 4 fimbriae expression regulatory protein PilR K02667 pilR; two-component system, NtrC family, response regulator PilR
B GlrK-GlrR (amino sugar metabolism)
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
C CNE_1c03100 dctB; C4-dicarboxylate transport sensor protein DctB K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]
C CNE_1c03090 dctD; C4-dicarboxylatetransporttranscriptional regulatory protein DctD K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
C CNE_2c14490 kinE; sporulation kinase E K02482 flgS; two-component system, NtrC family, sensor kinase [EC:2.7.13.3]
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ACheA family
B CheA-CheYBV (chemotaxis)
C CNE_2c02290 cheA1; chemotaxis protein CheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C CNE_2c02340 cheY2; chemotaxis response regulator K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C CNE_2c02200 cheY1; chemotaxis response regulator K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C CNE_2c02330 cheB1; chemotaxis response regulator protein-glutamate methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
C CNE_2c22180 cheV; chemotaxis specific response regulator containing a CheW-domain K03415 cheV; two-component system, chemotaxis family, chemotaxis protein CheV
B ChpA-ChpB/PilGH (chemosensory)
C CNE_1c07460 pilL; type IV pilus protein histidine kinase/response regulator hybrid PilL K06596 chpA; chemosensory pili system protein ChpA (sensor histidine kinase/response regulator)
C CNE_1c07420 pilG; type IV pilus response regulator PilG K02657 pilG; twitching motility two-component system response regulator PilG
C CNE_1c07430 pilH; type IV pilus response regulator PilH K02658 pilH; twitching motility two-component system response regulator PilH
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
C CNE_2c19990 cheA2; chemotaxis protein CheA K13490 wspE; two-component system, chemotaxis family, sensor histidine kinase and response regulator WspE
C CNE_2c20010 response regulator containing a GGDEF effector domain K11444 wspR; two-component system, chemotaxis family, response regulator WspR [EC:2.7.7.65]
C CNE_2c20000 cheB2; chemotaxis response regulator protein-glutamate methylesterase K13491 wspF; two-component system, chemotaxis family, response regulator WspF [EC:3.1.1.61]
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
C CNE_2c04350 cqsS1; CAI-1 autoinducer sensor kinase/phosphatase CqsS K10916 cqsS; two-component system, CAI-1 autoinducer sensor kinase/phosphatase CqsS [EC:2.7.13.3 3.1.3.-]
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
B AauS-AauR (acidic amino acids utilization)
C CNE_1c06850 gltS; signaltransduction histidine kinase regulating C4-dicarboxylatetransport system K17060 aauS; two-component system, sensor histidine kinase AauS [EC:2.7.13.3]
C CNE_1c06840 gltR; response regulator of C4-dicarboxylatetransportsystem K17061 aauR; two-component system, response regulator AauR
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
C CNE_1c01930 signal transduction histidine kinase K15011 regB; two-component system, sensor histidine kinase RegB [EC:2.7.13.3]
C CNE_1c01920 response regulator containing a Fis-type DNA-binding domain K15012 regA; two-component system, response regulator RegA
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
C CNE_1c30760 fixL; sensor protein FixL K19621 phcS; two-component system, sensor histidine kinase PhcS [EC:2.7.13.3]
C CNE_1c30750 phcR; signal transduction histidine kinase PhcR K19622 phcR; two-component system, response regulator PhcR
C CNE_1c30740 response regulator K19623 phcQ; two-component system, probable response regulator PhcQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
B PdtaS-PdtaR
B NasS-NasT
C CNE_1c03770 response regulator K07183 nasT; two-component system, response regulator / RNA-binding antiterminator
B Unclassified
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023