+C Two-component system KO
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Two-Component System - Escherichia coli O6:K2:H1 CFT073 (UPEC)
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C c0509 phoR; Phosphate regulon sensor protein phoR K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C c0508 phoB; Phosphate regulon transcriptional Regulatory protein phoB K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
C c1508 phoQ; Sensor protein phoQ K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]
C c1509 phoP; Transcriptional Regulatory protein phoP K07660 phoP; two-component system, OmpR family, response regulator PhoP
B EnvZ-OmpR (osmotic stress response)
C c4180 envZ; Osmolarity sensor protein envZ K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C c4181 ompR; Transcriptional Regulatory protein ompR K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
C c2001 rstB; Sensor protein rstB K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3]
C c2000 rstA; Transcriptional Regulatory protein rstA K07661 rstA; two-component system, OmpR family, response regulator RstA
B CpxA-CpxR (envelope stress response)
C c4863 cpxA; Sensor protein cpxA K07640 cpxA; two-component system, OmpR family, sensor histidine kinase CpxA [EC:2.7.13.3]
C c4864 cpxR; Transcriptional Regulatory protein cpxR K07662 cpxR; two-component system, OmpR family, response regulator CpxR
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
C c5486 creC; Sensor protein creC K07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3]
C c5485 creB; Transcriptional Regulatory protein creB K07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB
B BaeS-BaeR (envelope stress response)
C c2604 baeS; Sensor protein baeS K07642 baeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3]
C c2605 baeR; Transcriptional Regulatory protein baeR K07664 baeR; two-component system, OmpR family, response regulator BaeR
B BasS-BasR (antimicrobial peptide resistance)
C c5117 basS; Sensor protein basS/pmrB K07643 basS; two-component system, OmpR family, sensor histidine kinase BasS [EC:2.7.13.3]
C c5118 basR; Transcriptional Regulatory protein basR/pmrA K07771 basR; two-component system, OmpR family, response regulator BasR
B CusS-CusR (copper tolerance)
C c0656 cusS; Sensor kinase cusS K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C c0657 cusR; Transcriptional Regulatory protein cusR K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
B QseC-QseB (quorum sensing)
C c3765 ygiY; Sensor protein qseC K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C c3764 ygiX; Transcriptional Regulatory protein qseB K07666 qseB; two-component system, OmpR family, response regulator QseB
B KdpD-KdpE (potassium transport)
C c0780 kdpD; Sensor protein kdpD K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C c0779 kdpE; KDP operon transcriptional Regulatory protein kdpE K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
B TorS-TorR (TMAO respiration)
C c1128 torS; Sensor protein torS K07647 torS; two-component system, OmpR family, sensor histidine kinase TorS [EC:2.7.13.3]
C c1131 torR; TorCAD operon transcriptional Regulatory protein torR K07772 torR; two-component system, OmpR family, torCAD operon response regulator TorR
B ArcB-ArcA (anoxic redox control)
C c3970 arcB; Aerobic respiration control sensor protein arcB K07648 arcB; two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB [EC:2.7.13.3]
C c5488 arcA; Aerobic respiration control protein arcA K07773 arcA; two-component system, OmpR family, aerobic respiration control protein ArcA
B TctE-TctD (tricarboxylic acid transport)
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C c2386 yedV; Putative sensor-like histidine kinase yedV K02484 K02484; two-component system, OmpR family, sensor kinase [EC:2.7.13.3]
C c2387 yedW; Probable transcriptional Regulatory protein yedW K02483 K02483; two-component system, OmpR family, response regulator
C c3565 Putative response regulator K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
C c1682 narX; Nitrate/nitrite sensor protein narX K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3]
C c1681 narL; Nitrate/nitrite response regulator protein narL K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
B NarQ-NarP (nitrate respiration)
C c2996 narQ; Nitrate/nitrite sensor protein narQ K07674 narQ; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarQ [EC:2.7.13.3]
C c2730 narP; Nitrate/nitrite response regulator protein narP K07685 narP; two-component system, NarL family, nitrate/nitrite response regulator NarP
B UhpB-UhpA (hexose phosphates uptake)
C c4592 uhpB; Sensor protein uhpB K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]
C c4593 uhpA; Transcriptional Regulatory protein uhpA K07686 uhpA; two-component system, NarL family, uhpT operon response regulator UhpA
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
C c2761 rcsC; Sensor protein rcsC K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3]
C c2759 yojN; Putative sensor-like histidine kinase yojN K07676 rcsD; two-component system, NarL family, sensor histidine kinase RcsD [EC:2.7.13.3]
C c2760 rcsB; Capsular synthesis regulator component B K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
C c0365 Hypothetical protein K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
B BarA-UvrY (central carbon metabolism)
C c3349 barA; Sensor protein barA K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]
C c2327 uvrY; UvrY protein K07689 uvrY; two-component system, NarL family, invasion response regulator UvrY
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
C c2906 evgS; Sensor protein evgS precursor K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
C c2905 evgA; Positive transcription regulator evgA K07690 evgA; two-component system, NarL family, response regulator EvgA
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
B Unclassified
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
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ACitB family
B CitA-CitB (citrate fermentation)
C c0710 citA; Sensor kinase dpiB K07700 dpiB; two-component system, CitB family, cit operon sensor histidine kinase CitA [EC:2.7.13.3]
C c0711 citB; Transcriptional Regulatory protein dpiA K07702 dpiA; two-component system, CitB family, response regulator CitB
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
C c5131 yjdH; Sensor protein dcuS K07701 dcuS; two-component system, CitB family, sensor histidine kinase DcuS [EC:2.7.13.3]
C c5130 yjdG; Transcriptional Regulatory protein dcuR K07703 dcuR; two-component system, CitB family, response regulator DcuR
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
C c2656 yehU; Hypothetical protein yehU precursor K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C c2919 ypdA; Hypothetical protein ypdA K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C c4545 Hypothetical protein K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C c2920 ypdB; Hypothetical protein ypdB K02477 K02477; two-component system, LytTR family, response regulator
C c2655 yehT; Hypothetical protein yehT K02477 K02477; two-component system, LytTR family, response regulator
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
C c4818 glnL; Nitrogen regulation protein NR(II) K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]
C c4817 glnG; Nitrogen regulation protein NR(I) K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
C c4961 hydH; Sensor protein zraS K07709 zraS; two-component system, NtrC family, sensor histidine kinase HydH [EC:2.7.13.3]
C c4962 hydG; Transcriptional Regulatory protein zraR K07713 zraR; two-component system, NtrC family, response regulator HydG
B AtoS-AtoC (cPHB biosynthesis)
C c2762 atoS; Sensor protein atoS K07710 atoS; two-component system, NtrC family, sensor histidine kinase AtoS [EC:2.7.13.3]
C c2763 atoC; Acetoacetate metabolism Regulatory protein atoC K07714 atoC; two-component system, NtrC family, response regulator AtoC
B PilS-PilR (type 4 fimbriae synthesis)
B GlrK-GlrR (amino sugar metabolism)
C c3079 yfhK; Putative sensor-like histidine kinase yfhK K07711 glrK; two-component system, NtrC family, sensor histidine kinase GlrK [EC:2.7.13.3]
C c3077 yfhA; Hypothetical protein yfHa K07715 glrR; two-component system, NtrC family, response regulator GlrR
B PgtB-PgtA (phosphoglycerate transport)
C c5203 pgtB; Regulatory protein K08475 pgtB; two-component system, NtrC family, phosphoglycerate transport system sensor histidine kinase PgtB [EC:2.7.13.3]
C c5204 pgtA; Transport activator K08476 pgtA; two-component system, NtrC family, phosphoglycerate transport system response regulator PgtA
B DctB-DctD (C4-dicarboxylate transport)
C c5041 Putative transport sensor protein K10125 dctB; two-component system, NtrC family, C4-dicarboxylate transport sensor histidine kinase DctB [EC:2.7.13.3]
C c5040 Putative c4-dicarboxylate transport transcriptional Regulatory protein K10126 dctD; two-component system, NtrC family, C4-dicarboxylate transport response regulator DctD
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
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ACheA family
B CheA-CheYBV (chemotaxis)
C c2303 cheA; Chemotaxis protein cheA K03407 cheA; two-component system, chemotaxis family, sensor kinase CheA [EC:2.7.13.3]
C c2297 cheY; Chemotaxis protein cheY K03413 cheY; two-component system, chemotaxis family, chemotaxis protein CheY
C c2298 cheB; Protein-glutamate methylesterase K03412 cheB; two-component system, chemotaxis family, protein-glutamate methylesterase/glutaminase [EC:3.1.1.61 3.5.1.44]
B ChpA-ChpB/PilGH (chemosensory)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
B AauS-AauR (acidic amino acids utilization)
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
C c4546 Hypothetical protein K07720 yesN; two-component system, response regulator YesN
B CikA
B RegB-RegA (redox response)
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
B PdtaS-PdtaR
B NasS-NasT
B Unclassified
C c1699 hnr; Hnr protein K02485 rssB; two-component system, response regulator
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023