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Transfer RNA Biogenesis - Homo sapiens (human)
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AEukaryotic type
B 5'processing factors
C Ribonucrease P
D 10940 POP1; POP1 homolog, ribonuclease P/MRP subunit K01164 POP1; ribonuclease P/MRP protein subunit POP1 [EC:3.1.26.5]
D 10775 POP4; POP4 homolog, ribonuclease P/MRP subunit K03538 POP4; ribonuclease P protein subunit POP4 [EC:3.1.26.5]
D 51367 POP5; POP5 homolog, ribonuclease P/MRP subunit K03537 POP5; ribonuclease P/MRP protein subunit POP5 [EC:3.1.26.5]
D 10556 RPP30; ribonuclease P/MRP subunit p30 K03539 RPP1; ribonuclease P/MRP protein subunit RPP1 [EC:3.1.26.5]
D 79897 RPP21; ribonuclease P/MRP subunit p21 K03540 RPR2; ribonuclease P protein subunit RPR2 [EC:3.1.26.5]
D 11102 RPP14; ribonuclease P/MRP subunit p14 K14529 RPP14; ribonuclease P protein subunit RPP14 [EC:3.1.26.5]
D 10248 POP7; POP7 homolog, ribonuclease P/MRP subunit K14527 RPP20; ribonuclease P/MRP protein subunit RPP20 [EC:3.1.26.5]
D 138716 RPP25L; ribonuclease P/MRP subunit p25 like K14525 RPP25; ribonucleases P/MRP protein subunit RPP25 [EC:3.1.26.5]
D 54913 RPP25; ribonuclease P and MRP subunit p25 K14525 RPP25; ribonucleases P/MRP protein subunit RPP25 [EC:3.1.26.5]
D 10557 RPP38; ribonuclease P/MRP subunit p38 K14523 RPP38; ribonucleases P/MRP protein subunit RPP38 [EC:3.1.26.5]
D 10799 RPP40; ribonuclease P/MRP subunit p40 K14530 RPP40; ribonucleases P/MRP protein subunit RPP40 [EC:3.1.26.5]
B 3'processing and CCA adding factors
C 3'processing factors
D 60528 ELAC2; elaC ribonuclease Z 2 K00784 rnz; ribonuclease Z [EC:3.1.26.11]
D 55520 ELAC1; elaC ribonuclease Z 1 K00784 rnz; ribonuclease Z [EC:3.1.26.11]
D 8635 RNASET2; ribonuclease T2 K01166 RNASET2; ribonuclease T2 [EC:4.6.1.19]
D 100526740 ATP5MF-PTCD1; ATP5MF-PTCD1 readthrough K17710 PTCD1; pentatricopeptide repeat domain-containing protein 1
D 26024 PTCD1; pentatricopeptide repeat domain 1 K17710 PTCD1; pentatricopeptide repeat domain-containing protein 1
C CCA adding factors
D 51095 TRNT1; tRNA nucleotidyl transferase 1 K00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]
B tRNA spricing factors
C tRNA splicing endonuclease complex
D 80746 TSEN2; tRNA splicing endonuclease subunit 2 K15322 TSEN2; tRNA-splicing endonuclease subunit Sen2 [EC:4.6.1.16]
D 79042 TSEN34; tRNA splicing endonuclease subunit 34 K15323 TSEN34; tRNA-splicing endonuclease subunit Sen34 [EC:4.6.1.16]
D 116461 TSEN15; tRNA splicing endonuclease subunit 15 K15324 TSEN15; tRNA-splicing endonuclease subunit Sen15
D 283989 TSEN54; tRNA splicing endonuclease subunit 54 K15326 TSEN54; tRNA-splicing endonuclease subunit Sen54
C tRNA splicing ligase complex
D 51493 RTCB; RNA 2',3'-cyclic phosphate and 5'-OH ligase K14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
D 79074 C2orf49; chromosome 2 open reading frame 49 K15432 ASW; ashwin
D 51637 RTRAF; RNA transcription, translation and transport factor K15433 CGI99; RLL motif containing protein 1
D 283742 FAM98B; family with sequence similarity 98 member B K15434 FAM98B; protein FAM98B
D 1653 DDX1; DEAD-box helicase 1 K13177 DDX1; ATP-dependent RNA helicase DDX1 [EC:5.6.2.7]
D 339487 ZBTB8OS; zinc finger and BTB domain containing 8 opposite strand K24956 ZBTB8OS; protein archease
C Other tRNA splicing factors
D 83707 TRPT1; tRNA phosphotransferase 1 K10669 TRPT1; 2'-phosphotransferase [EC:2.7.1.160]
B tRNA transport factors
C tRNA export factors
D 5901 RAN; RAN, member RAS oncogene family K07936 RAN; GTP-binding nuclear protein Ran
D 11260 XPOT; exportin for tRNA K14288 XPOT; exportin-T
D 7514 XPO1; exportin 1 K14290 XPO1; exportin-1
D 57510 XPO5; exportin 5 K14289 XPO5; exportin-5
D 1915 EEF1A1; eukaryotic translation elongation factor 1 alpha 1 K03231 EEF1A; elongation factor 1-alpha
D 1917 EEF1A2; eukaryotic translation elongation factor 1 alpha 2 K03231 EEF1A; elongation factor 1-alpha
D 57410 SCYL1; SCY1 like pseudokinase 1 K08876 SCYL1; SCY1-like protein 1
D 9567 GTPBP1; GTP binding protein 1 K24887 GTPBP1; GTP-binding protein 1
C tRNA import factors
D 23534 TNPO3; transportin 3 K15436 TRPO3; transportin-3
B Aminoacyl-tRNA synthetases (AARSs)
C Multi-aminoacyl-tRNA synthetase complex (MSC)
D 2058 EPRS1; glutamyl-prolyl-tRNA synthetase 1 K14163 EPRS; bifunctional glutamyl/prolyl-tRNA synthetase [EC:6.1.1.17 6.1.1.15]
D 124454 EARS2; glutamyl-tRNA synthetase 2, mitochondrial K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D 25973 PARS2; prolyl-tRNA synthetase 2, mitochondrial K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
D 3376 IARS1; isoleucyl-tRNA synthetase 1 K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D 55699 IARS2; isoleucyl-tRNA synthetase 2, mitochondrial K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D 51520 LARS1; leucyl-tRNA synthetase 1 K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D 23395 LARS2; leucyl-tRNA synthetase 2, mitochondrial K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D 4141 MARS1; methionyl-tRNA synthetase 1 K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D 92935 MARS2; methionyl-tRNA synthetase 2, mitochondrial K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D 5859 QARS1; glutaminyl-tRNA synthetase 1 K01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18]
D 57038 RARS2; arginyl-tRNA synthetase 2, mitochondrial K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D 5917 RARS1; arginyl-tRNA synthetase 1 K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D 3735 KARS1; lysyl-tRNA synthetase 1 K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D 1615 DARS1; aspartyl-tRNA synthetase 1 K22503 DARS1; aspartyl-tRNA synthetase [EC:6.1.1.12]
D 55157 DARS2; aspartyl-tRNA synthetase 2, mitochondrial K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D 9255 AIMP1; aminoacyl tRNA synthetase complex interacting multifunctional protein 1 K15437 AIMP1; aminoacyl tRNA synthase complex-interacting multifunctional protein 1
D 7965 AIMP2; aminoacyl tRNA synthetase complex interacting multifunctional protein 2 K15438 AIMP2; aminoacyl tRNA synthase complex-interacting multifunctional protein 2
D 9521 EEF1E1; eukaryotic translation elongation factor 1 epsilon 1 K15439 EEF1E1; eukaryotic translation elongation factor 1 epsilon-1
C Other AARSs
D 57505 AARS2; alanyl-tRNA synthetase 2, mitochondrial K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D 16 AARS1; alanyl-tRNA synthetase 1 K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D 79731 NARS2; asparaginyl-tRNA synthetase 2, mitochondrial K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D 4677 NARS1; asparaginyl-tRNA synthetase 1 K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D 2617 GARS1; glycyl-tRNA synthetase 1 K01880 GARS; glycyl-tRNA synthetase [EC:6.1.1.14]
D 80222 TARS2; threonyl-tRNA synthetase 2, mitochondrial K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D 6897 TARS1; threonyl-tRNA synthetase 1 K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D 123283 TARS3; threonyl-tRNA synthetase 3 K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D 54938 SARS2; seryl-tRNA synthetase 2, mitochondrial K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D 6301 SARS1; seryl-tRNA synthetase 1 K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D 833 CARS1; cysteinyl-tRNA synthetase 1 K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D 79587 CARS2; cysteinyl-tRNA synthetase 2, mitochondrial K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D 57176 VARS2; valyl-tRNA synthetase 2, mitochondrial K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D 7407 VARS1; valyl-tRNA synthetase 1 K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D 3035 HARS1; histidyl-tRNA synthetase 1 K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D 23438 HARS2; histidyl-tRNA synthetase 2, mitochondrial K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D 2193 FARSA; phenylalanyl-tRNA synthetase subunit alpha K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D 10667 FARS2; phenylalanyl-tRNA synthetase 2, mitochondrial K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D 10056 FARSB; phenylalanyl-tRNA synthetase subunit beta K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D 8565 YARS1; tyrosyl-tRNA synthetase 1 K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D 51067 YARS2; tyrosyl-tRNA synthetase 2 K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D 10352 WARS2; tryptophanyl tRNA synthetase 2, mitochondrial K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D 7453 WARS1; tryptophanyl-tRNA synthetase 1 K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
C Trans-editing factors
D 92675 DTD1; D-aminoacyl-tRNA deacylase 1 K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D 112487 DTD2; D-aminoacyl-tRNA deacylase 2 K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D 80755 AARSD1; alanyl-tRNA synthetase domain containing 1 K07050 AARSD1; misacylated tRNA(Ala) deacylase [EC:3.1.1.-]
D 100885850 PTGES3L-AARSD1; PTGES3L-AARSD1 readthrough K07050 AARSD1; misacylated tRNA(Ala) deacylase [EC:3.1.1.-]
C AARS associated factors
D 54952 TRNAU1AP; tRNA selenocysteine 1 associated protein 1 K25102 TRNAU1AP; tRNA selenocysteine 1-associated protein 1
D 3094 HINT1; histidine triad nucleotide binding protein 1 K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]
D 84681 HINT2; histidine triad nucleotide binding protein 2 K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-]
D 135114 HINT3; histidine triad nucleotide binding protein 3 K12150 HINT3; adenosine 5'-monophosphoramidase HINT3 [EC:3.9.1.-]
B tRNA modification factors
C Deaminases
D 23536 ADAT1; adenosine deaminase tRNA specific 1 K15440 TAD1; tRNA-specific adenosine deaminase 1 [EC:3.5.4.34]
D 134637 ADAT2; adenosine deaminase tRNA specific 2 K15441 TAD2; tRNA-specific adenosine deaminase 2 [EC:3.5.4.-]
D 113179 ADAT3; adenosine deaminase tRNA specific 3 K15442 TAD3; tRNA-specific adenosine deaminase 3
C Dihydorouridine synthases
D 64118 DUS1L; dihydrouridine synthase 1 like K05542 DUS1; tRNA-dihydrouridine synthase 1 [EC:1.3.1.88]
D 54920 DUS2; dihydrouridine synthase 2 K05543 DUS2; tRNA-dihydrouridine synthase 2 [EC:1.3.1.91]
D 56931 DUS3L; dihydrouridine synthase 3 like K05544 DUS3; tRNA-dihydrouridine synthase 3 [EC:1.3.1.89]
D 11062 DUS4L; dihydrouridine synthase 4 like K05545 DUS4; tRNA-dihydrouridine synthase 4 [EC:1.3.1.90]
C Methylthiotransferase
D 54901 CDKAL1; CDK5 regulatory subunit associated protein 1 like 1 K15865 CDKAL1; threonylcarbamoyladenosine tRNA methylthiotransferase CDKAL1 [EC:2.8.4.5]
C Methyltransferases
D 55621 TRMT1; tRNA methyltransferase 1 K00555 TRMT1; tRNA (guanine26-N2/guanine27-N2)-dimethyltransferase [EC:2.1.1.215 2.1.1.216]
D 27037 TRMT2A; tRNA methyltransferase 2 homolog A K15332 TRMT2A; tRNA (uracil-5-)-methyltransferase [EC:2.1.1.-]
D 79979 TRMT2B; tRNA methyltransferase 2 homolog B K15331 TRMT2B; tRNA (uracil-5-)-methyltransferase [EC:2.1.1.35]
D 6894 TARBP1; TAR (HIV-1) RNA binding protein 1 K15333 TRM3; tRNA guanosine-2'-O-methyltransferase [EC:2.1.1.34]
D 54888 NSUN2; NOP2/Sun RNA methyltransferase 2 K15335 NSUN2; tRNA (cytosine34-C5)-methyltransferase [EC:2.1.1.203]
D 63899 NSUN3; NOP2/Sun RNA methyltransferase 3 K21969 NSUN3; tRNA (cytosine34-C5)-methyltransferase [EC:2.1.1.-]
D 221078 NSUN6; NOP2/Sun RNA methyltransferase 6 K21971 NSUN6; methyltransferase NSUN6 [EC:2.1.1.-]
D 57570 TRMT5; tRNA methyltransferase 5 K15429 TRM5; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]
D 115708 TRMT61A; tRNA methyltransferase 61A K07442 TRM61; tRNA (adenine57-N1/adenine58-N1)-methyltransferase catalytic subunit [EC:2.1.1.219 2.1.1.220]
D 55006 TRMT61B; tRNA methyltransferase 61B K07442 TRM61; tRNA (adenine57-N1/adenine58-N1)-methyltransferase catalytic subunit [EC:2.1.1.219 2.1.1.220]
D 51605 TRMT6; tRNA methyltransferase 6 non-catalytic subunit K03256 TRM6; tRNA (adenine58-N1)-methyltransferase non-catalytic subunit
D 24140 FTSJ1; FtsJ RNA 2'-O-methyltransferase 1 K14864 FTSJ1; tRNA (cytidine32/guanosine34-2'-O)-methyltransferase [EC:2.1.1.205]
D 4234 METTL1; methyltransferase 1, tRNA methylguanosine K03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]
D 55798 METTL2B; methyltransferase 2B, tRNA N3-cytidine K24974 METTL2; tRNA N(3)-methylcytidine methyltransferase METTL2 [EC:2.1.1.-]
D 339175 METTL2A; methyltransferase 2A, tRNA N3-cytidine K24974 METTL2; tRNA N(3)-methylcytidine methyltransferase METTL2 [EC:2.1.1.-]
D 131965 METTL6; methyltransferase 6, tRNA N3-cytidine K00599 METTL6; tRNA N(3)-methylcytidine methyltransferase METTL6 [EC:2.1.1.-]
D 91801 ALKBH8; alkB homolog 8, tRNA methyltransferase K10770 ALKBH8; alkylated DNA repair protein alkB homolog 8 [EC:1.14.11.- 2.1.1.229]
D 93587 TRMT10A; tRNA methyltransferase 10A K15445 TRMT10; tRNA (guanine9-N1)-methyltransferase [EC:2.1.1.221]
D 158234 TRMT10B; tRNA methyltransferase 10B K15445 TRMT10; tRNA (guanine9-N1)-methyltransferase [EC:2.1.1.221]
D 60487 TRMT11; tRNA methyltransferase 11 homolog K15430 TRM11; tRNA (guanine10-N2)-methyltransferase [EC:2.1.1.214]
D 54482 TRMT13; tRNA methyltransferase 13 homolog K15446 TRM13; tRNA:m4X modification enzyme [EC:2.1.1.225]
D 152992 TRMT44; tRNA methyltransferase 44 homolog K15447 TRM44; tRNASer (uridine44-2'-O)-methyltransferase [EC:2.1.1.211]
D 10785 WDR4; WD repeat domain 4 K15443 TRM82; tRNA (guanine-N(7)-)-methyltransferase subunit TRM82
D 51504 TRMT112; tRNA methyltransferase activator subunit 11-2 K15448 TRM112; multifunctional methyltransferase subunit TRM112
D 1787 TRDMT1; tRNA aspartic acid methyltransferase 1 K15336 TRDMT1; tRNA (cytosine38-C5)-methyltransferase [EC:2.1.1.204]
D 51531 TRMO; tRNA methyltransferase O K22900 TRMO; tRNA (adenine37-N6)-methyltransferase [EC:2.1.1.-]
D 55253 TYW1; tRNA-yW synthesizing protein 1 homolog K15449 TYW1; tRNA wybutosine-synthesizing protein 1 [EC:4.1.3.44]
D 441250 TYW1B; tRNA-yW synthesizing protein 1 homolog B K15449 TYW1; tRNA wybutosine-synthesizing protein 1 [EC:4.1.3.44]
D 55039 TRMT12; tRNA methyltransferase 12 homolog K07055 TRM12; tRNA wybutosine-synthesizing protein 2 [EC:2.5.1.114]
D 127253 TYW3; tRNA-yW synthesizing protein 3 homolog K15450 TYW3; tRNA wybutosine-synthesizing protein 3 [EC:2.1.1.282]
D 9836 LCMT2; leucine carboxyl methyltransferase 2 K15451 PPM2; tRNA wybutosine-synthesizing protein 4 [EC:2.1.1.290 2.3.1.231]
D 129450 TYW5; tRNA-yW synthesizing protein 5 K18066 TYW5; tRNA wybutosine-synthesizing protein 5 [EC:1.14.11.42]
D 144233 BCDIN3D; BCDIN3 domain containing RNA methyltransferase K25191 BCDIN3D; RNA 5'-monophosphate methyltransferase [EC:2.1.1.-]
C Psudouridine synthases
D 80324 PUS1; pseudouridine synthase 1 K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]
D 83480 PUS3; pseudouridine synthase 3 K01855 PUS3; tRNA pseudouridine38/39 synthase [EC:5.4.99.45]
D 142940 TRUB1; TruB pseudouridine synthase family member 1 K03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]
D 83448 PUS7L; pseudouridine synthase 7 like K06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]
D 54517 PUS7; pseudouridine synthase 7 K06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]
D 150962 PUS10; pseudouridine synthase 10 K07583 PUS10; tRNA pseudouridine synthase 10 [EC:5.4.99.25]
D 84881 RPUSD4; RNA pseudouridine synthase D4 K22538 RPUSD4; mitochondrial RNA pseudouridine synthase RPUSD4 [EC:5.4.99.-]
C Thiolation factors
D 55687 TRMU; tRNA mitochondrial 2-thiouridylase K21027 TRMU; tRNA-5-taurinomethyluridine 2-sulfurtransferase [EC:2.8.1.14]
D 90353 CTU1; cytosolic thiouridylase subunit 1 K14168 CTU1; cytoplasmic tRNA 2-thiolation protein 1 [EC:2.7.7.-]
D 348180 CTU2; cytosolic thiouridylase subunit 2 K14169 CTU2; cytoplasmic tRNA 2-thiolation protein 2
D 9054 NFS1; NFS1 cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
D 81605 URM1; ubiquitin related modifier 1 K12161 URM1; ubiquitin related modifier 1
D 27304 MOCS3; molybdenum cofactor synthesis 3 K11996 MOCS3; adenylyltransferase and sulfurtransferase [EC:2.7.7.80 2.8.1.11]
C KEOPS/EKC complex
D 112858 TP53RK; TP53 regulating kinase K08851 TP53RK; TP53 regulating kinase and related kinases [EC:2.7.11.1]
D 64172 OSGEPL1; O-sialoglycoprotein endopeptidase like 1 K01409 OSGEP; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]
D 55644 OSGEP; O-sialoglycoprotein endopeptidase K01409 OSGEP; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]
D 51002 TPRKB; TP53RK binding protein K15901 TPRKB; EKC/KEOPS complex subunit TPRKB/CGI121
D 8270 LAGE3; L antigen family member 3 K15902 LAGE3; EKC/KEOPS complex subunit LAGE3/PCC1
D 84520 GON7; GON7 subunit of KEOPS complex K15903 GON7; EKC/KEOPS complex subunit GON7
C Elongator complex
D 8518 ELP1; elongator acetyltransferase complex subunit 1 K11373 ELP1; elongator complex protein 1
D 55250 ELP2; elongator acetyltransferase complex subunit 2 K11374 ELP2; elongator complex protein 2
D 55140 ELP3; elongator acetyltransferase complex subunit 3 K07739 ELP3; elongator complex protein 3 (tRNA carboxymethyluridine synthase) [EC:2.3.1.311]
D 26610 ELP4; elongator acetyltransferase complex subunit 4 K11375 ELP4; elongator complex protein 4
D 23587 ELP5; elongator acetyltransferase complex subunit 5 K11376 ELP5; elongator complex protein 5
D 54859 ELP6; elongator acetyltransferase complex subunit 6 K11377 ELP6; elongator complex protein 6
C Elongator related proteins
D 285381 DPH3; diphthamide biosynthesis 3 K15455 DPH3; diphthamide biosynthesis protein 3
D 112970 KTI12; KTI12 chromatin associated homolog K15456 KTI12; protein KTI12
C Other tRNA modification factors
D 79693 YRDC; yrdC N6-threonylcarbamoyltransferase domain containing K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
D 54802 TRIT1; tRNA isopentenyltransferase 1 K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]
D 84705 GTPBP3; GTP binding protein 3, mitochondrial K03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]
D 25821 MTO1; mitochondrial tRNA translation optimization 1 K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme
D 81890 QTRT1; queuine tRNA-ribosyltransferase catalytic subunit 1 K00777 QTRT1; queuine tRNA-ribosyltransferase catalytic subunit [EC:2.4.2.64]
D 79691 QTRT2; queuine tRNA-ribosyltransferase accessory subunit 2 K15407 QTRT2; queuine tRNA-ribosyltransferase accessory subunit
D 22928 SEPHS2; selenophosphate synthetase 2 K01008 selD; selenide, water dikinase [EC:2.7.9.3]
D 22929 SEPHS1; selenophosphate synthetase 1 K01008 selD; selenide, water dikinase [EC:2.7.9.3]
D 55623 THUMPD1; THUMP domain containing 1 K06963 TAN1; tRNA acetyltransferase TAN1
D 54974 THG1L; tRNA-histidine guanylyltransferase 1 like K10761 THG1; tRNA(His) guanylyltransferase [EC:2.7.7.79]
D 11101 ATE1; arginyltransferase 1 K00685 ATE1; arginyl-tRNA---protein transferase [EC:2.3.2.8]
D 55152 DALRD3; DALR anticodon binding domain containing 3 K24973 DALRD3; DALR anticodon-binding domain-containing protein 3
B tRNA degradation factors
C TRAMP complex
D 11044 TENT4A; terminal nucleotidyltransferase 4A K03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5/7 [EC:2.7.7.19]
D 64282 TENT4B; terminal nucleotidyltransferase 4B K03514 PAPD5_7; non-canonical poly(A) RNA polymerase PAPD5/7 [EC:2.7.7.19]
D 84186 ZCCHC7; zinc finger CCHC-type containing 7 K12597 AIR1_2; protein AIR1/2
D 23517 MTREX; Mtr4 exosome RNA helicase K12598 MTR4; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6]
C Rapid tRNA decay (RTD) pathway factors
D 54464 XRN1; 5'-3' exoribonuclease 1 K12618 XRN1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]
D 22803 XRN2; 5'-3' exoribonuclease 2 K12619 XRN2; 5'-3' exoribonuclease 2 [EC:3.1.13.-]
D 10380 BPNT1; 3'(2'), 5'-bisphosphate nucleotidase 1 K01082 cysQ; 3'(2'), 5'-bisphosphate nucleotidase [EC:3.1.3.7]
C Other tRNA degradation factors
D 283 ANG; angiogenin K16631 ANG; angiogenin [EC:3.1.27.-]
D 146857 SLFN13; schlafen family member 13 K24459 SLFN13; schlafen family member 13 [EC:3.1.-.-]
D 24138 IFIT5; interferon induced protein with tetratricopeptide repeats 5 K24850 IFIT5; interferon-induced protein with tetratricopeptide repeats 5
#
AProkaryotic type
B 5'processing factors
C Ribonucrease P
B 3'processing and CCA adding factors
C 3'processing factors
D 60528 ELAC2; elaC ribonuclease Z 2 K00784 rnz; ribonuclease Z [EC:3.1.26.11]
D 55520 ELAC1; elaC ribonuclease Z 1 K00784 rnz; ribonuclease Z [EC:3.1.26.11]
D 8635 RNASET2; ribonuclease T2 K01166 RNASET2; ribonuclease T2 [EC:4.6.1.19]
C CCA adding factors
D 51095 TRNT1; tRNA nucleotidyl transferase 1 K00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]
B tRNA spricing factors
C tRNA splicing endonucleases
C tRNA splicing ligases
D 51493 RTCB; RNA 2',3'-cyclic phosphate and 5'-OH ligase K14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
C Other tRNA splicing factors
B tRNA transport factors
C tRNA export factors
B Aminoacyl-tRNA synthetases (AARSs)
C Multi-aminoacyl-tRNA synthetase complex (MSC)
D 51520 LARS1; leucyl-tRNA synthetase 1 K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D 23395 LARS2; leucyl-tRNA synthetase 2, mitochondrial K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
D 25973 PARS2; prolyl-tRNA synthetase 2, mitochondrial K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
C Other AARSs
D 8565 YARS1; tyrosyl-tRNA synthetase 1 K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D 51067 YARS2; tyrosyl-tRNA synthetase 2 K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
D 10352 WARS2; tryptophanyl tRNA synthetase 2, mitochondrial K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D 7453 WARS1; tryptophanyl-tRNA synthetase 1 K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
D 80222 TARS2; threonyl-tRNA synthetase 2, mitochondrial K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D 6897 TARS1; threonyl-tRNA synthetase 1 K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D 123283 TARS3; threonyl-tRNA synthetase 3 K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
D 3376 IARS1; isoleucyl-tRNA synthetase 1 K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D 55699 IARS2; isoleucyl-tRNA synthetase 2, mitochondrial K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
D 3735 KARS1; lysyl-tRNA synthetase 1 K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
D 57505 AARS2; alanyl-tRNA synthetase 2, mitochondrial K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D 16 AARS1; alanyl-tRNA synthetase 1 K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
D 57176 VARS2; valyl-tRNA synthetase 2, mitochondrial K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D 7407 VARS1; valyl-tRNA synthetase 1 K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
D 4141 MARS1; methionyl-tRNA synthetase 1 K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D 92935 MARS2; methionyl-tRNA synthetase 2, mitochondrial K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
D 54938 SARS2; seryl-tRNA synthetase 2, mitochondrial K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D 6301 SARS1; seryl-tRNA synthetase 1 K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
D 55157 DARS2; aspartyl-tRNA synthetase 2, mitochondrial K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
D 833 CARS1; cysteinyl-tRNA synthetase 1 K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D 79587 CARS2; cysteinyl-tRNA synthetase 2, mitochondrial K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
D 124454 EARS2; glutamyl-tRNA synthetase 2, mitochondrial K01885 EARS; glutamyl-tRNA synthetase [EC:6.1.1.17]
D 5859 QARS1; glutaminyl-tRNA synthetase 1 K01886 QARS; glutaminyl-tRNA synthetase [EC:6.1.1.18]
D 57038 RARS2; arginyl-tRNA synthetase 2, mitochondrial K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D 5917 RARS1; arginyl-tRNA synthetase 1 K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
D 2193 FARSA; phenylalanyl-tRNA synthetase subunit alpha K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D 10667 FARS2; phenylalanyl-tRNA synthetase 2, mitochondrial K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
D 10056 FARSB; phenylalanyl-tRNA synthetase subunit beta K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
D 3035 HARS1; histidyl-tRNA synthetase 1 K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D 23438 HARS2; histidyl-tRNA synthetase 2, mitochondrial K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
D 79731 NARS2; asparaginyl-tRNA synthetase 2, mitochondrial K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
D 4677 NARS1; asparaginyl-tRNA synthetase 1 K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
C Trans-editing factors
D 92675 DTD1; D-aminoacyl-tRNA deacylase 1 K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D 112487 DTD2; D-aminoacyl-tRNA deacylase 2 K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
D 80755 AARSD1; alanyl-tRNA synthetase domain containing 1 K07050 AARSD1; misacylated tRNA(Ala) deacylase [EC:3.1.1.-]
D 100885850 PTGES3L-AARSD1; PTGES3L-AARSD1 readthrough K07050 AARSD1; misacylated tRNA(Ala) deacylase [EC:3.1.1.-]
B tRNA modification factors
C Deaminases
C Dihydorouridine synthases
C Methylthiotransferases
C Methyltransferases
D 4234 METTL1; methyltransferase 1, tRNA methylguanosine K03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]
D 84705 GTPBP3; GTP binding protein 3, mitochondrial K03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]
D 51531 TRMO; tRNA methyltransferase O K22900 TRMO; tRNA (adenine37-N6)-methyltransferase [EC:2.1.1.-]
C Psudouridine synthases
D 80324 PUS1; pseudouridine synthase 1 K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]
D 142940 TRUB1; TruB pseudouridine synthase family member 1 K03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]
D 83448 PUS7L; pseudouridine synthase 7 like K06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]
D 54517 PUS7; pseudouridine synthase 7 K06176 truD; tRNA pseudouridine13 synthase [EC:5.4.99.27]
C Thiolation factors
D 9054 NFS1; NFS1 cysteine desulfurase K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
C KEOPS/EKC complex
D 112858 TP53RK; TP53 regulating kinase K08851 TP53RK; TP53 regulating kinase and related kinases [EC:2.7.11.1]
D 64172 OSGEPL1; O-sialoglycoprotein endopeptidase like 1 K01409 OSGEP; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]
D 55644 OSGEP; O-sialoglycoprotein endopeptidase K01409 OSGEP; N6-L-threonylcarbamoyladenine synthase [EC:2.3.1.234]
C Other tRNA modification factors
D 25821 MTO1; mitochondrial tRNA translation optimization 1 K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme
D 54802 TRIT1; tRNA isopentenyltransferase 1 K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]
D 5805 PTS; 6-pyruvoyltetrahydropterin synthase K01737 queD; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]
D 22928 SEPHS2; selenophosphate synthetase 2 K01008 selD; selenide, water dikinase [EC:2.7.9.3]
D 22929 SEPHS1; selenophosphate synthetase 1 K01008 selD; selenide, water dikinase [EC:2.7.9.3]
D 79693 YRDC; yrdC N6-threonylcarbamoyltransferase domain containing K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
B tRNA degradation factors
C 87178 PNPT1; polyribonucleotide nucleotidyltransferase 1 K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]
C 3669 ISG20; interferon stimulated exonuclease gene 20 K12579 ISG20; interferon-stimulated gene 20 kDa protein [EC:3.1.13.1]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: February 29, 2024