+E Messenger RNA Biogenesis
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Messenger RNA Biogenesis
!
AEukaryotic type
B mRNA processing factors
C 5' end processing
D Capping factors
E K00565 RNMT; mRNA (guanine-N7-)-methyltransferase [EC:2.1.1.56]
E K13917 RNGTT; mRNA-capping enzyme [EC:2.7.7.50 3.6.1.74]
E K04563 CDC28, CDC2; cyclin-dependent kinase [EC:2.7.11.22]
E K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E K00987 CEG1; mRNA guanylyltransferase [EC:2.7.7.50]
E K01098 CET1; polynucleotide 5'-triphosphatase [EC:3.6.1.74]
E K14589 CMTR1, FTSJD2, MTR1; cap1 methyltransferase [EC:2.1.1.57]
E K14590 CMTR2, FTSJD1, AFT; cap2 methyltransferase [EC:2.1.1.296]
E K18776 MTR2, MT48; cap2 methyltransferase [EC:2.1.1.296]
E K18777 MTR3, MT57; cap3/cap4 methyltransferase [EC:2.1.1.-]
E K18708 FAM103A1; RNMT-activating mini protein
D Cap binding complex
E K12882 NCBP1, CBP80; nuclear cap-binding protein subunit 1
E K12883 NCBP2, CBP20; nuclear cap-binding protein subunit 2
C 3' end processing
D Pre-mRNA cleavage factor Im (CFIm)
E K14397 NUDT21, CPSF5, CFIM25; cleavage and polyadenylation specificity factor subunit 5
E K14398 CPSF6_7; cleavage and polyadenylation specificity factor subunit 6/7
D Pre-mRNA cleavage factor IIm (CFIIm)
E K14399 CLP1, HERB; polyribonucleotide 5'-hydroxyl-kinase [EC:2.7.1.78]
E K14400 PCF11; pre-mRNA cleavage complex 2 protein Pcf11
D Cleavage and polyadenylation specificity factor (CPSF) complex
E K14401 CPSF1, CFT1; cleavage and polyadenylation specificity factor subunit 1
E K14402 CPSF2, CFT2; cleavage and polyadenylation specificity factor subunit 2
E K14403 CPSF3, YSH1; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
E K14404 CPSF4, YTH1; cleavage and polyadenylation specificity factor subunit 4
E K14405 FIP1L1, FIP1; pre-mRNA 3'-end-processing factor FIP1
E K15541 MPE1; protein MPE1
E K15542 PFS2; polyadenylation factor subunit 2
E K14962 WDR82, SWD2, CPS35; COMPASS component SWD2
E K15543 REF2; RNA end formation protein 2
E K06269 PPP1C; serine/threonine-protein phosphatase PP1 catalytic subunit [EC:3.1.3.16]
E K15544 SSU72; RNA polymerase II subunit A C-terminal domain phosphatase SSU72 [EC:3.1.3.16]
D Cleavage stimulation factor (CSTF) complex
E K14406 CSTF1; cleavage stimulation factor subunit 1
E K14407 CSTF2, RNA15; cleavage stimulation factor subunit 2
E K14408 CSTF3, RNA14; cleavage stimulation factor subunit 3
E K06100 SYMPK; symplekin
D U7-dependent histone pre-mRNA processing factors
E K11086 SNRPB, SMB; small nuclear ribonucleoprotein B and B'
E K11088 SNRPD3, SMD3; small nuclear ribonucleoprotein D3
E K11097 SNRPE, SME; small nuclear ribonucleoprotein E
E K11098 SNRPF, SMF; small nuclear ribonucleoprotein F
E K11099 SNRPG, SMG; small nuclear ribonucleoprotein G
E K25591 LSM10; U7 snRNA-associated Sm-like protein LSm10
E K25592 LSM11; U7 snRNA-associated Sm-like protein LSm11
E K14402 CPSF2, CFT2; cleavage and polyadenylation specificity factor subunit 2
E K14403 CPSF3, YSH1; cleavage and polyadenylation specificity factor subunit 3 [EC:3.1.27.-]
E K14407 CSTF2, RNA15; cleavage stimulation factor subunit 2
E K06100 SYMPK; symplekin
E K18710 SLBP; histone RNA hairpin-binding protein
E K25593 CASP8AP2; CASP8-associated protein 2
D DRB sensitivity inducing factor (DSIF) complex
E K15171 SUPT4H1, SPT4; transcription elongation factor SPT4
E K15172 SUPT5H, SPT5; transcription elongation factor SPT5
D N6-methyltransferase complex
E K05925 METTL3; mRNA m6A methyltransferase catalytic subunit [EC:2.1.1.348]
E K23960 METTL14; mRNA m6A methyltransferase non-catalytic subunit
E K24174 METTL4; N(6)-adenine-specific DNA methyltransferase [EC:2.1.1.72]
E K11393 METTL16, METT10D; U6 snRNA m6A methyltransferase [EC:2.1.1.346]
E K22824 WTAP; pre-mRNA-splicing regulator WTAP
E K22910 VIRMA; protein virilizer
E K13190 RBM15; RNA-binding protein 15
E K22909 ZC3H13; zinc finger CCCH domain-containing protein 13
E K15685 CBLL1; E3 ubiquitin-protein ligase Hakai [EC:2.3.2.27]
D Poly(A) addition factors
E K14376 PAP; poly(A) polymerase [EC:2.7.7.19]
E K14079 PAPD4, GLD2; poly(A) RNA polymerase GLD2 [EC:2.7.7.19]
E K18709 TUT1; speckle targeted PIP5K1A-regulated poly(A) polymerase [EC:2.7.7.19 2.7.7.52]
D Negative regulators of mRNA 3' end processing
E K10683 BARD1; BRCA1-associated RING domain protein 1
E K13192 RBM26; RNA-binding protein 26
E K19469 FTO; mRNA N6-methyladenine demethylase [EC:1.14.11.53]
E K10767 ALKBH5; mRNA N6-methyladenine demethylase [EC:1.14.11.53]
E K23600 TARDBP, TDP43; TAR DNA-binding protein 43
C Other processing factors
D K18711 DHX40; ATP-dependent RNA helicase DHX40 [EC:5.6.2.6]
D K13102 KIN; DNA/RNA-binding protein KIN17
D K24975 METTL8; mRNA N(3)-methylcytidine methyltransferase METTL8 [EC:2.1.1.-]
D K23040 METTL22; methyltransferase-like protein 22 [EC:2.1.1.-]
D K23033 TENT5A_B, FAM46A_B; terminal nucleotidyltransferase 5A/B [EC:2.7.7.-]
D K23034 TENT5C, FAM46C; terminal nucleotidyltransferase 5C [EC:2.7.7.19]
D K23035 TENT5D, FAM46D; terminal nucleotidyltransferase 5D [EC:2.7.7.19]
D K23038 ZC3H14; zinc finger CCCH domain-containing protein 14
D K27103 SRRT, ARS2; serrate RNA effector molecule
D K23039 NAB2; nuclear polyadenylated RNA-binding protein NAB2
B mRNA surveillance and transport factors
C Transport factors
D EJC complex
E K12876 RBM8A, Y14; RNA-binding protein 8A
E K12877 MAGOH; protein mago nashi
E K12881 THOC4, ALY; THO complex subunit 4
E K12812 DDX39B, UAP56, SUB2; ATP-dependent RNA helicase UAP56/SUB2 [EC:5.6.2.7]
E K13025 EIF4A3, FAL1; ATP-dependent RNA helicase [EC:5.6.2.7]
E K25178 CCDC174; coiled-coil domain-containing protein 174
E K14323 CASC3, MLN51; protein CASC3
E K14324 SAP18; histone deacetylase complex subunit SAP18
E K13114 PNN; pinin
E K12875 ACIN1, ACINUS; apoptotic chromatin condensation inducer in the nucleus
E K14325 RNPS1; RNA-binding protein with serine-rich domain 1
E K13171 SRRM1, SRM160; serine/arginine repetitive matrix protein 1
D TREX complex
E K12878 THOC1; THO complex subunit 1
E K12879 THOC2; THO complex subunit 2
E K12880 THOC3; THO complex subunit 3
E K12881 THOC4, ALY; THO complex subunit 4
E K13174 THOC5; THO complex subunit 5
E K13175 THOC6; THO complex subunit 6
E K13176 THOC7; THO complex subunit 7
E K18712 HPR1; THO complex subunit HPR1
E K18713 THP2; THO complex subunit THP2
E K18714 MFT1; THO complex subunit MFT1
D TREX-2 complex
E K23801 PCID2, THP1; nuclear mRNA export protein PCID2/THP1
E K10881 SHFM1, DSS1, RPN15; 26 proteasome complex subunit DSS1
E K11368 ENY2, DC6, SUS1; enhancer of yellow 2 transcription factor
E K10840 CETN2; centrin-2
E K16466 CETN3, CDC31; centrin-3
E K24317 MCM3AP; germinal-center associated nuclear protein [EC:2.3.1.48]
E K23719 SAC3; nuclear mRNA export protein SAC3
D Nuclear pore complex
E K09291 TPR, MLP1, MLP2; nucleoprotein TPR
E K14298 RAE1, GLE2; mRNA export factor
E K14004 SEC13; protein transport protein SEC13
E K14302 NUP37; nuclear pore complex protein Nup37
E K14304 NUP85; nuclear pore complex protein Nup85
E K14305 NUP43; nuclear pore complex protein Nup43
E K14295 NUP50, NPAP60; nuclear pore complex protein Nup50
E K14308 NUP54, NUP57; nuclear pore complex protein Nup54
E K14306 NUP62, NSP1; nuclear pore complex protein Nup62
E K14318 NUP88; nuclear pore complex protein Nup88
E K14309 NUP93, NIC96; nuclear pore complex protein Nup93
E K14297 NUP98, ADAR2, NUP116; nuclear pore complex protein Nup98-Nup96
E K14301 NUP107, NUP84; nuclear pore complex protein Nup107
E K14300 NUP133; nuclear pore complex protein Nup133
E K14311 NUP188; nuclear pore complex protein Nup188
E K14296 NUP153; nuclear pore complex protein Nup153
E K14312 NUP155, NUP170, NUP157; nuclear pore complex protein Nup155
E K14303 NUP160, NUP120; nuclear pore complex protein Nup160
E K14313 NUP35, NUP53; nuclear pore complex protein Nup53
E K14310 NUP205, NUP192; nuclear pore complex protein Nup205
E K14314 NUP210, GP210; nuclear pore complex protein Nup210
E K14317 NUP214, CAN; nuclear pore complex protein Nup214
E K14316 POM121, NUP121; nuclear pore complex protein Nup121
E K14307 NUPL1, NUP49; nucleoporin p58/p45
E K14321 NUPL2, NUP42, CG1; nucleoporin-like protein 2
E K14315 NDC1, TMEM48; nucleoporin NDC1
E K14299 SEH1; nucleoporin SEH1
E K12172 RANBP2, NUP358; E3 SUMO-protein ligase RanBP2 [EC:2.3.2.-]
E K03345 SENP2, AXAM2; sentrin-specific protease 2 (axin associating molecule) [EC:3.4.22.68]
E K14320 AAAS; aladin
E K18715 NUP159; nucleoporin NUP159
E K18716 NUP42, RIP1; nucleoporin NUP42
E K18717 ASM4, NUP59; nucleoporin ASM4
E K18718 NUP60; nucleoporin NUP60
E K18719 NUP82; nucleoporin NUP82
E K18720 NUP145; nucleoporin NUP145
E K18721 NUP1; nucleoporin NUP1
E K18722 NUP2; nucleoporin NUP2
E K16466 CETN3, CDC31; centrin-3
E K18723 GLE1; nucleoporin GLE1
E K14284 NXF, TAP, MEX67; nuclear RNA export factor
E K14285 NXT1_2, P15; NTF2-related export protein 1/2
E K26564 NPAP1; nuclear pore-associated protein 1
E K14543 MTR2; mRNA transport regulator MTR2
E K18724 POM34; nucleoporin POM34
E K18725 POM152; nucleoporin POM152
E K14017 SNL1; HSP70 co-chaperone SNL1
D Ran-mediated transport factors
E K07936 RAN; GTP-binding nuclear protein Ran
E K18646 ANP32A_C_D; acidic leucine-rich nuclear phosphoprotein 32 family member A/C/D
E K18647 ANP32B; acidic leucine-rich nuclear phosphoprotein 32 family member B
E K05475 TNFSF13, APRIL, CD256; tumor necrosis factor ligand superfamily member 13
E K13088 ELAVL1, HUR; ELAV-like protein 1
E K13208 ELAVL2_3_4; ELAV like protein 2/3/4
E K18726 FAF2, UBXD8; FAS-associated factor 2
E K13525 VCP, CDC48; transitional endoplasmic reticulum ATPase
E K21806 VCPKMT, METTL21D; protein N-lysine methyltransferase METTL21D [EC:2.1.1.-]
E K18727 TNPO2, IPO3, KPNB2B; transportin-2
E K14290 XPO1, CRM1; exportin-1
E K18460 XPO7, EXP7; exportin-7
E K24115 RANBP17; Ran-binding protein 17
E K14319 RANGAP1; Ran GTPase-activating protein 1
E K14651 TAF15, NPL3; transcription initiation factor TFIID subunit 15
D eIF4F and regulatory proteins
E K03259 EIF4E; translation initiation factor 4E
E K03257 EIF4A; translation initiation factor 4A
E K03260 EIF4G; translation initiation factor 4G
E K03258 EIF4B; translation initiation factor 4B
E K24086 EIF4H; translation initiation factor 4H
E K07205 EIF4EBP1; eukaryotic translation initiation factor 4E binding protein 1
E K18644 EIF4EBP2; eukaryotic translation initiation factor 4E binding protein 2
E K18645 EIF4EBP3; eukaryotic translation initiation factor 4E binding protein 3
E K18728 EIF4ENIF1; eukaryotic translation initiation factor 4E transporter
E K18729 ANGEL; protein angel
E K15516 FMR; fragile X mental retardation protein
E K05749 CYFIP; cytoplasmic FMR1 interacting protein
E K13133 GEMIN5; gem associated protein 5
E K14283 TACC3, maskin; transforming acidic coiled-coil-containing protein 3
E K02602 CPEB, ORB; cytoplasmic polyadenylation element-binding protein
E K11594 DDX3X, bel; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]
E K18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein
E K13126 PABPC; polyadenylate-binding protein
E K14322 PAIP1; polyadenylate-binding protein-interacting protein 1
E K27470 PAIP2; polyadenylate-binding protein-interacting protein 2
E K12599 SKI2, SKIV2L; antiviral helicase SKI2 [EC:5.6.2.6]
E K18664 SLH1; antiviral helicase SLH1 [EC:5.6.2.6]
E K23041 DEAF1; deformed epidermal autoregulatory factor 1
E K07575 MCTS, TMA20; malignant T-cell-amplified sequence
E K24272 DENR, TMA22; density-regulated protein
D APOBEC1-ACF complex
E K16932 APOBEC1; C->U-editing enzyme APOBEC1 [EC:3.5.4.36]
E K24978 A1CF; APOBEC1 complementation factor
D Other transport factors
E K14294 WIBG, PYM; partner of Y14 and mago
E K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3
E K14411 MSI; RNA-binding protein Musashi
E K14416 HBS1; elongation factor 1 alpha-like protein
E K06965 PELO, DOM34, pelA; protein pelota
E K14396 PABPN1, PABP2; polyadenylate-binding protein 2
E K18731 GFD1; mRNA transport factor GFD1
E K18655 DDX19, DBP5; ATP-dependent RNA helicase DDX19/DBP5 [EC:5.6.2.7]
E K18656 DDX25, GRTH; ATP-dependent RNA helicase DDX25 [EC:5.6.2.7]
E K12867 SYF1, XAB2; pre-mRNA-splicing factor SYF1
E K18732 SARNP, CIP29, THO1; SAP domain-containing ribonucleoprotein
E K11493 RCC1; regulator of chromosome condensation
E K18733 LARP6; la-related protein 6
E K21772 PURA; transcriptional activator protein Pur-alpha
E K21799 PURB; transcriptional activator protein Pur-beta
E K22414 POLDIP3; polymerase delta-interacting protein 3
E K22415 ZC3H11; zinc finger CCCH domain-containing protein 11
E K23802 LENG8, THP3; SAC3 family protein LENG8/THP3
E K24823 PATL2; protein PAT1 homolog 2
E K23799 YRA2; RNA annealing protein YRA2
C Surveillance factors
D Surveillance complex
E K03265 ETF1, ERF1; peptide chain release factor subunit 1
E K03267 ERF3, GSPT; peptide chain release factor subunit 3
E K14326 UPF1, RENT1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]
E K14327 UPF2, RENT2; regulator of nonsense transcripts 2
E K14328 UPF3, RENT3; regulator of nonsense transcripts 3
D Protein phosphatase 2A
E K04382 PPP2C; serine/threonine-protein phosphatase 2A catalytic subunit [EC:3.1.3.16]
E K03456 PPP2R1; serine/threonine-protein phosphatase 2A regulatory subunit A
E K04354 PPP2R2; serine/threonine-protein phosphatase 2A regulatory subunit B
E K11583 PPP2R3; serine/threonine-protein phosphatase 2A regulatory subunit B''
E K11584 PPP2R5; serine/threonine-protein phosphatase 2A regulatory subunit B'
D Other surveillance factors
E K08873 SMG1; serine/threonine-protein kinase SMG1 [EC:2.7.11.1]
E K11125 SMG5, EST1B; protein SMG5
E K11124 SMG6, EST1A; protein SMG6 [EC:3.1.-.-]
E K14409 SMG7, EST1C; protein SMG7
E K18734 SMG8; protein SMG8
E K18735 SMG9; protein SMG9
E K18730 GIGYF; PERQ amino acid-rich with GYF domain-containing protein
E K19539 SECISBP2, SBP2; selenocysteine insertion sequence-binding protein 2
E K20101 DHX34; ATP-dependent RNA helicase DHX34 [EC:5.6.2.6]
E K24887 GTPBP1; GTP-binding protein 1
C Factors involved in mRNA localization
D Cargo complex
E K18736 SHE2; SWI5-dependent HO expression protein 2
E K18737 SHE3; SWI5-dependent HO expression protein 3
E K14844 PUF6; pumilio homology domain family member 6
E K18738 HEK; heterogeneous nuclear rnp K-like protein
E K10357 MYO5; myosin V
E K18658 ASH1; transcriptional regulatory protein ASH1
E K18739 BICD; protein bicaudal D
E K18740 EXD1, EGL; exonuclease 3'-5' domain-containing protein 1
D Factors that have mRNA localization signals
E K05692 ACTB_G1; actin beta/gamma 1
E K17269 MBP; myelin basic protein
E K07606 VIM; vimentin
E K14739 MT1_2; metallothionein 1/2
E K04377 MYC; Myc proto-oncogene protein
E K18659 BCD; homeotic protein bicoid
E K05495 GDF1; growth differentiation factor 1
E K10180 TBX6; T-box protein 6
E K18741 NANOS1, NOS1; protein nanos 1
E K18742 OSK; maternal effect protein oskar
E K02524 K10; DNA binding protein (fs(1)K10, female sterile(1)K10)
E K02447 GRK; protein gruken
E K09090 HESN; hairy and enhancer of split, invertebrate
D Trans-acting binding proteins
E K12965 ZBP1, DAI; Z-DNA binding protein 1
E K13210 FUBP; far upstream element-binding protein
E K03231 EEF1A; elongation factor 1-alpha
E K03233 EEF1G; elongation factor 1-gamma
E K13158 HNRNPA2B1; heterogeneous nuclear ribonucleoprotein A2/B1
E K16220 HAX1; HCLS1-associated protein X-1
E K15044 AGFG1; Arf-GAP domain and FG repeats-containing protein 1
E K17597 STAU; double-stranded RNA-binding protein Staufen
E K13197 IGF2BP3; insulin-like growth factor 2 mRNA-binding protein 3
E K13218 PTBP1, PTB; polypyrimidine tract-binding protein 1
E K03102 SQD; squid
E K02602 CPEB, ORB; cytoplasmic polyadenylation element-binding protein
D Other mRNA localization factors
E K15516 FMR; fragile X mental retardation protein
E K05749 CYFIP; cytoplasmic FMR1 interacting protein
E K13162 PCBP2; poly(rC)-binding protein 2
E K21444 PCBP3_4; poly(rC)-binding protein 3/4
E K18743 CAPRIN1, GPIAP1; caprin-1
E K18744 CAPRIN2, EEG1; caprin-2
E K02177 BRU; bruno
E K18745 EXU; maternal protein exuperantia
E K09276 YBX1, NSEP1; Y-box-binding protein 1
E K18746 CUP; protein cup
E K18747 SXL; protein sex-lethal
E K18748 SSD1; protein SSD1
C mRNA cycle factors
D Common to processing body (P body) and stress granule
E K12618 XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]
E K11593 ELF2C, AGO; eukaryotic translation initiation factor 2C
E K03259 EIF4E; translation initiation factor 4E
E K14326 UPF1, RENT1; regulator of nonsense transcripts 1 [EC:5.6.2.5 5.6.2.3]
E K11594 DDX3X, bel; ATP-dependent RNA helicase DDX3X [EC:5.6.2.7]
E K17642 DDX3Y; ATP-dependent RNA helicase DDX3Y [EC:5.6.2.7]
E K12614 DDX6, RCK, DHH1; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7]
E K15686 MEX3, RKHD; RNA-binding protein MEX3 [EC:2.3.2.27]
E K08290 FASTK; Fas-activated serine/threonine kinase [EC:2.7.11.8]
E K18749 LSM14, RAP55, SCD6; protein LSM14
E K12889 PCBP1; poly(rC)-binding protein 1
E K13162 PCBP2; poly(rC)-binding protein 2
E K09276 YBX1, NSEP1; Y-box-binding protein 1
E K16682 AJUBA, LIMD1, WTIP; LIM domain-containing protein
E K16932 APOBEC1; C->U-editing enzyme APOBEC1 [EC:3.5.4.36]
E K18750 APOBEC3; C->U-editing enzyme APOBEC3 [EC:3.5.4.-]
E K18422 MOV10; helicase MOV-10 [EC:5.6.2.5]
E K18751 PNRC2; proline-rich nuclear receptor coactivator 2
E K18752 TNPO1, IPO2, KPNB2; transportin-1
E K08873 SMG1; serine/threonine-protein kinase SMG1 [EC:2.7.11.1]
E K11125 SMG5, EST1B; protein SMG5
E K11124 SMG6, EST1A; protein SMG6 [EC:3.1.-.-]
E K14409 SMG7, EST1C; protein SMG7
E K15308 TTP; tristetraprolin
E K18753 ZFP36L; butyrate response factor
E K18754 LIN28; protein lin-28
E K04533 HD; huntingtin
E K18755 IPO8, RANBP8; importin-8
E K18756 BICC1, BICC; protein bicaudal C
E K12741 HNRNPA1_3; heterogeneous nuclear ribonucleoprotein A1/A3
E K04345 PKA; protein kinase A [EC:2.7.11.11]
E K18757 LARP1; la-related protein 1
E K23625 ATXN2_2L; ataxin 2/2L
D P-body specific factors
E K12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]
E K12610 DCP1A; mRNA-decapping enzyme 1A [EC:3.-.-.-]
E K12611 DCP1B; mRNA-decapping enzyme 1B [EC:3.-.-.-]
E K12612 DCP1; mRNA-decapping enzyme subunit 1
E K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1
E K12621 LSM2; U6 snRNA-associated Sm-like protein LSm2
E K12622 LSM3; U6 snRNA-associated Sm-like protein LSm3
E K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4
E K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5
E K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6
E K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7
E K12627 LSM8; U6 snRNA-associated Sm-like protein LSm8
E K10407 KLC; kinesin light chain
E K10357 MYO5; myosin V
E K07374 TUBA; tubulin alpha
E K02602 CPEB, ORB; cytoplasmic polyadenylation element-binding protein
E K13133 GEMIN5; gem associated protein 5
E K14283 TACC3, maskin; transforming acidic coiled-coil-containing protein 3
E K18412 TNRC6, GW182; trinucleotide repeat-containing gene 6 protein
E K12604 CNOT1, NOT1; CCR4-NOT transcription complex subunit 1
E K12605 CNOT2, NOT2; CCR4-NOT transcription complex subunit 2
E K12580 CNOT3, NOT3; CCR4-NOT transcription complex subunit 3
E K10643 CNOT4, NOT4, MOT2; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
E K12603 CNOT6, CCR4; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]
E K12581 CNOT7_8, CAF1, POP2; CCR4-NOT transcription complex subunit 7/8
E K26671 GARRE1; granule associated Rac and RHOG effector protein 1
E K18758 DIS3L2; DIS3-like exonuclease 2 [EC:3.1.13.-]
E K12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]
E K12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3
E K14443 TOB; protein Tob/BTG
E K18728 EIF4ENIF1; eukaryotic translation initiation factor 4E transporter
E K12617 PATL1, PAT1; DNA topoisomerase 2-associated protein PAT1
E K18759 EDC1_2; enhancer of mRNA-decapping protein 1/2
E K12615 EDC3; enhancer of mRNA-decapping protein 3
E K12616 EDC4; enhancer of mRNA-decapping protein 4
E K18760 NANOS2, NOS2; protein nanos 2
E K18761 NANOS3, NOS3; protein nanos 3
E K14327 UPF2, RENT2; regulator of nonsense transcripts 2
E K14328 UPF3, RENT3; regulator of nonsense transcripts 3
E K10651 TRIM21, SSA1; tripartite motif-containing protein 21 [EC:2.3.2.27]
E K12035 TRIM71; tripartite motif-containing protein 71 [EC:2.3.2.27]
E K03015 RPB7, POLR2G; DNA-directed RNA polymerase II subunit RPB7
E K16195 EIF2AK2; eukaryotic translation initiation factor 2-alpha kinase 2 [EC:2.7.11.1]
E K18762 ZAR1; zygote arrest protein 1
E K20102 YTHDF; YTH domain-containing family protein
D Stress granule specific factors
E K13201 TIA1, TIAL1; nucleolysin TIA-1/TIAR
E K13126 PABPC; polyadenylate-binding protein
E K17597 STAU; double-stranded RNA-binding protein Staufen
E K15516 FMR; fragile X mental retardation protein
E K12965 ZBP1, DAI; Z-DNA binding protein 1
E K13088 ELAVL1, HUR; ELAV-like protein 1
E K17265 G3BP1; Ras GTPase-activating protein-binding protein 1 [EC:5.6.2.5 5.6.2.3]
E K24983 G3BP2; Ras GTPase-activating protein-binding protein 2
E K15026 EIF2A; translation initiation factor 2A
E K03253 EIF3B; translation initiation factor 3 subunit B
E K03257 EIF4A; translation initiation factor 4A
E K13025 EIF4A3, FAL1; ATP-dependent RNA helicase [EC:5.6.2.7]
E K03258 EIF4B; translation initiation factor 4B
E K03260 EIF4G; translation initiation factor 4G
E K04373 RPS6KA; ribosomal protein S6 kinase alpha-1/2/3/6 [EC:2.7.11.1]
E K14753 RACK1; guanine nucleotide-binding protein subunit beta-2-like 1 protein
E K03173 TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
E K14284 NXF, TAP, MEX67; nuclear RNA export factor
E K11407 HDAC6; histone deacetylase 6 [EC:3.5.1.98]
E K18404 TDRD3; tudor domain-containing protein 3
E K18763 LARP4; la-related protein 4
B mRNA degradation factors
C 5'-3' decay
D Decapping complex
E K12610 DCP1A; mRNA-decapping enzyme 1A [EC:3.-.-.-]
E K12611 DCP1B; mRNA-decapping enzyme 1B [EC:3.-.-.-]
E K12612 DCP1; mRNA-decapping enzyme subunit 1
E K12613 DCP2; mRNA-decapping enzyme subunit 2 [EC:3.6.1.62]
E K12614 DDX6, RCK, DHH1; ATP-dependent RNA helicase DDX6/DHH1 [EC:5.6.2.7]
E K18759 EDC1_2; enhancer of mRNA-decapping protein 1/2
E K12615 EDC3; enhancer of mRNA-decapping protein 3
E K12616 EDC4; enhancer of mRNA-decapping protein 4
E K12617 PATL1, PAT1; DNA topoisomerase 2-associated protein PAT1
D Lsm complex
E K12620 LSM1; U6 snRNA-associated Sm-like protein LSm1
E K12621 LSM2; U6 snRNA-associated Sm-like protein LSm2
E K12622 LSM3; U6 snRNA-associated Sm-like protein LSm3
E K12623 LSM4; U6 snRNA-associated Sm-like protein LSm4
E K12624 LSM5; U6 snRNA-associated Sm-like protein LSm5
E K12625 LSM6; U6 snRNA-associated Sm-like protein LSm6
E K12626 LSM7; U6 snRNA-associated Sm-like protein LSm7
E K12627 LSM8; U6 snRNA-associated Sm-like protein LSm8
D 5' exonucleases
E K12618 XRN1, SEP1, KEM1; 5'-3' exoribonuclease 1 [EC:3.1.13.-]
E K12619 XRN2, RAT1; 5'-3' exoribonuclease 2 [EC:3.1.13.-]
E K20553 XRN4; 5'-3' exoribonuclease 4 [EC:3.1.13.-]
E K16855 NUDT16; U8 snoRNA-decapping enzyme [EC:3.6.1.62 3.6.1.64]
D Other 5'-3' decay factors
E K12584 DCPS, DCS; m7GpppX diphosphatase [EC:3.6.1.59]
E K25168 HELZ; helicase with zinc finger domain [EC:5.6.2.-]
C 3'-5' decay
D Core exosome factors
E K07573 CSL4, EXOSC1; exosome complex component CSL4
E K03679 RRP4, EXOSC2; exosome complex component RRP4
E K03681 RRP40, EXOSC3; exosome complex component RRP40
E K11600 RRP41, EXOSC4, SKI6; exosome complex component RRP41
E K12590 RRP46, EXOSC5; exosome complex component RRP46
E K12587 MTR3, EXOSC6; exosome complex component MTR3
E K12589 RRP42, EXOSC7; exosome complex component RRP42
E K12586 RRP43, EXOSC8, OIP2; exosome complex component RRP43
E K03678 RRP45, EXOSC9; exosome complex component RRP45
D Exosome cofactors
E K12585 DIS3, RRP44; exosome complex exonuclease DIS3/RRP44 [EC:3.1.13.-]
E K18681 DIS3L; DIS3-like exonuclease 1 [EC:3.1.13.-]
E K12591 RRP6, EXOSC10; exosome complex exonuclease RRP6 [EC:3.1.13.-]
E K12592 C1D, LRP1; exosome complex protein LRP1
E K12593 MPHOSPH6, MPP6; M-phase phosphoprotein 6, animal type
E K12594 MPP6; M-phase phosphoprotein 6, fungi type
E K12595 SKI7; superkiller protein 7
E K20103 DDX60; ATP-dependent RNA helicase DDX60 [EC:5.6.2.7]
D TRAMP complex
E K03514 PAPD5_7, TRF4; non-canonical poly(A) RNA polymerase PAPD5/7 [EC:2.7.7.19]
E K12597 AIR1_2; protein AIR1/2
E K12598 MTR4, SKIV2L2; ATP-dependent RNA helicase DOB1 [EC:5.6.2.6]
E K12596 TRF5; poly(A) RNA polymerase
D Ski complex
E K12599 SKI2, SKIV2L; antiviral helicase SKI2 [EC:5.6.2.6]
E K12600 SKI3, TTC37; superkiller protein 3
E K12601 SKI8; superkiller protein 8
E K12602 WDR61, REC14, SKI8; WD repeat-containing protein 61
D Ccr4-NOT complex
E K12603 CNOT6, CCR4; CCR4-NOT transcription complex subunit 6 [EC:3.1.13.4]
E K12604 CNOT1, NOT1; CCR4-NOT transcription complex subunit 1
E K12605 CNOT2, NOT2; CCR4-NOT transcription complex subunit 2
E K12580 CNOT3, NOT3; CCR4-NOT transcription complex subunit 3
E K10643 CNOT4, NOT4, MOT2; CCR4-NOT transcription complex subunit 4 [EC:2.3.2.27]
E K12581 CNOT7_8, CAF1, POP2; CCR4-NOT transcription complex subunit 7/8
E K12606 RCD1, CNOT9, CAF40; CCR4-NOT transcription complex subunit 9
E K12607 CNOT10; CCR4-NOT transcription complex subunit 10
E K12608 CAF16; CCR4-NOT complex subunit CAF16
E K12609 CAF120; CCR4-NOT transcriptional complex subunit CAF120
D Pan complex
E K12571 PAN2; PAB-dependent poly(A)-specific ribonuclease subunit 2 [EC:3.1.13.4]
E K12572 PAN3; PAB-dependent poly(A)-specific ribonuclease subunit 3
D Other 3'-5' decay factors
E K01148 PARN, PNLDC1; poly(A)-specific ribonuclease [EC:3.1.13.4]
E K14442 DHX36, RHAU; ATP-dependent RNA helicase DHX36 [EC:5.6.2.6]
E K14443 TOB; protein Tob/BTG
E K05427 CSF2, GMCSF; granulocyte-macrophage colony-stimulating factor
E K18764 NOCT, CCRN4L; nocturnin [EC:3.1.3.108]
E K18416 THEX1, ERI1; 3'-5' exoribonuclease 1 [EC:3.1.-.-]
E K18417 ERI2; ERI1 exoribonuclease 2 [EC:3.1.-.-]
E K12584 DCPS, DCS; m7GpppX diphosphatase [EC:3.6.1.59]
E K19612 PDE12; 2',5'-phosphodiesterase [EC:3.1.13.4 3.1.4.-]
E K22416 IREB2; iron-responsive element-binding protein 2
E K25168 HELZ; helicase with zinc finger domain [EC:5.6.2.-]
E K25165 HELZ2; 3'-5' exoribonuclease HELZ2 [EC:3.1.13.1 5.6.2.6]
E K26109 NRDE2; nuclear exosome regulator NRDE2
E K27396 SMG; protein Smaug
E K27498 FOCAD; focadhesin
E K27407 VTS1; RNA-binding protein VTS1
C Other degradation factors
D RNases
E K01168 RNASE1_2; pancreatic ribonuclease [EC:4.6.1.18]
E K10787 RNASE3, ECP; eosinophil cationic protein [EC:3.1.27.-]
E K16632 RNASE4; ribonuclease 4 [EC:3.1.27.-]
E K01172 RNASE6_7_8; ribonuclease 6/7/8 [EC:3.1.27.-]
E K16633 RNASE11; ribonuclease 11 [EC:3.1.27.-]
E K18668 ZC3H12, MCPIP; ribonuclease ZC3H12 [EC:3.1.-.-]
E K23175 RNU2; ribonuclease U2 [EC:4.6.1.20]
#
AProkaryotic type
B Bacterial mRNA degradation factors
C RNA degradosome components
D Ribonucreases
E K08300 rne; ribonuclease E [EC:3.1.26.12]
E K08301 rng, cafA; ribonuclease G [EC:3.1.26.-]
E K03685 rnc, DROSHA, RNT1; ribonuclease III [EC:3.1.26.3]
E K12574 rnj; ribonuclease J [EC:3.1.-.-]
E K18682 rny; ribonucrease Y [EC:3.1.-.-]
E K12573 rnr, vacB; ribonuclease R [EC:3.1.13.1]
E K01167 rnaSA; ribonuclease T1 [EC:4.6.1.24]
E K13288 orn, REX2, REXO2; oligoribonuclease [EC:3.1.-.-]
E K03698 cbf, cbf1; 3'-5' exoribonuclease [EC:3.1.-.-]
D Helicases
E K03732 rhlB; ATP-dependent RNA helicase RhlB [EC:5.6.2.7]
E K11927 rhlE; ATP-dependent RNA helicase RhlE [EC:5.6.2.7]
E K05592 deaD, cshA; ATP-dependent RNA helicase DeaD [EC:5.6.2.7]
E K18692 cshB; ATP-dependent RNA helicase CshB [EC:5.6.2.7]
E K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
D Other RNA degradosome components
E K01689 ENO1_2_3, eno; enolase 1/2/3 [EC:4.2.1.11]
E K00962 pnp, PNPT1; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]
E K03628 rho; transcription termination factor Rho
E K00850 pfkA, PFK; 6-phosphofructokinase 1 [EC:2.7.1.11]
C Other RNA degradation factors
D Chaperones
E K04043 dnaK, HSPA9; molecular chaperone DnaK
E K04077 groEL, HSPD1; chaperonin GroEL [EC:5.6.1.7]
E K03666 hfq; host factor-I protein
D Others
E K00937 ppk1; polyphosphate kinase [EC:2.7.4.1]
E K22468 ppk2; polyphosphate kinase [EC:2.7.4.34]
E K00970 pcnB; poly(A) polymerase [EC:2.7.7.19]
E K08311 nudH; putative (di)nucleoside polyphosphate hydrolase [EC:3.6.1.-]
E K03563 csrA; carbon storage regulator
E K18765 csrD; RNase E specificity factor CsrD
E K02553 rraA, menG; regulator of ribonuclease activity A
E K09893 rraB; regulator of ribonuclease activity B
E K06958 rapZ; RNase adapter protein RapZ
E K03727 helY; ATP-dependent RNA helicase HelY [EC:5.6.2.6]
E K03578 hrpA; ATP-dependent RNA helicase HrpA [EC:5.6.2.6]
E K03579 hrpB; ATP-dependent RNA helicase HrpB [EC:5.6.2.6]
D Bacterial Small RNA Regulators
E K18502 dsrA; small regulatory RNA DsrA
E K18503 chiX, sroB; small regulatory RNA ChiX
E K18504 arcZ; small regulatory RNA ArcZ
E K15841 glmY; small regulatory RNA GlmY
E K18505 glmZ; small regulatory RNA GlmZ
E K18506 sgrS; small regulatory RNA SgrS
E K18507 ryhB; small regulatory RNA RyhB
E K18508 rybB; small regulatory RNA RybB
E K18509 rydC; small regulatory RNA RydC
E K18510 fnrS; small regulatory RNA FnrS
E K18511 micA; small regulatory RNA MicA
E K18512 micC; small regulatory RNA MicC
E K18513 micF; small regulatory RNA MicF
E K18514 mgrR; small regulatory RNA MgrR
E K18515 csrB; small regulatory RNA CsrB
E K18516 csrC; small regulatory RNA CsrC
E K18517 dicF; small regulatory RNA DicF
E K18518 rprA; small regulatory RNA RprA
E K18519 rseX; small regulatory RNA RseX
E K18520 cyaR, ryeE; small regulatory RNA CyaR
E K18521 gcvB; small regulatory RNA GcvB
E K18522 omrA, rygA; small regulatory RNA OmrA
E K18523 omrB, rygB; small regulatory RNA OmrB
E K18525 gadY; small regulatory RNA GadY
E K18526 istR; sRNA antisense regulator of TisB protein
E K18527 spf; small regulatory RNA Spot 42
E K18528 oxyS; small regulatory RNA OxyS
B Archeal mRNA degradation factors
C Exosome components
D Core exosome
E K03679 RRP4, EXOSC2; exosome complex component RRP4
E K07573 CSL4, EXOSC1; exosome complex component CSL4
D Cofactors
E K11600 RRP41, EXOSC4, SKI6; exosome complex component RRP41
E K12589 RRP42, EXOSC7; exosome complex component RRP42
D Others
E K03725 K03725; putative ATP-dependent RNA helicase [EC:5.6.2.-]
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#
#[ BRITE | KEGG2 | KEGG ]
#Last updated: April 25, 2024