+C Two-component system KO
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Two-Component System - Klebsiella pneumoniae subsp. rhinoscleromatis SB3432
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AOmpR family
B PhoR-PhoB (phosphate starvation response)
C KPR_4383 phoR; highly similar to phosphate regulon sensor protein PhoR from Klebsiella pneumoniae (sp|P45608) K07636 phoR; two-component system, OmpR family, phosphate regulon sensor histidine kinase PhoR [EC:2.7.13.3]
C KPR_4384 phoB; highly similar to phosphate regulon transcriptional regulatory protein PhoB from Klebsiella pneumoniae (sp|P45605) K07657 phoB; two-component system, OmpR family, phosphate regulon response regulator PhoB
B SenX3-RegX3 (phosphate starvation response)
B PhoQ-PhoP (magnesium transport)
C KPR_2180 phoQ; highly similar to sensor protein PhoQ from Escherichia coli strain K12 (sp|P23837) K07637 phoQ; two-component system, OmpR family, sensor histidine kinase PhoQ [EC:2.7.13.3]
C KPR_2181 phoP; highly similar to virulence transcriptional regulatory protein PhoP from Salmonella typhimurium (sp|P14146) K07660 phoP; two-component system, OmpR family, response regulator PhoP
C KPR_1574 unnamed protein product; highly similar to putative response regulator receiver from Klebsiella pneumoniae NTUH-K2044 (tr|C4XB02) K07660 phoP; two-component system, OmpR family, response regulator PhoP
B EnvZ-OmpR (osmotic stress response)
C KPR_0694 envZ; highly similar to osmolarity sensor protein EnvZ from Salmonella typhimurium (sp|P08982) K07638 envZ; two-component system, OmpR family, osmolarity sensor histidine kinase EnvZ [EC:2.7.13.3]
C KPR_0693 ompR; highly similar to transcriptional regulatory protein OmpR from Escherichia coli strain UTI89 - UPEC (tr|Q1R5N0) K07659 ompR; two-component system, OmpR family, phosphate regulon response regulator OmpR
B RstB-RstA
C KPR_2824 rstB; highly similar to putative sensor protein from Escherichia coli strain UTI89 - UPEC (tr|Q1RBI9) K07639 rstB; two-component system, OmpR family, sensor histidine kinase RstB [EC:2.7.13.3]
C KPR_2822 rstA; highly similar to DNA-binding response regulator in two-component regulatory system with RstB from Escherichia coli O7:K1 strain IAI39 - ExPEC (tr|B7NUN1) K07661 rstA; two-component system, OmpR family, response regulator RstA
B CpxA-CpxR (envelope stress response)
C KPR_0178 cpxA; highly similar to putative sensor protein from Escherichia coli O6:K15:H31 strain 536 - UPEC (tr|Q0TAF2) K07640 cpxA; two-component system, OmpR family, sensor histidine kinase CpxA [EC:2.7.13.3]
C KPR_0179 cpxR; highly similar to putative transcriptional regulatory protein CpxR from Escherichia coli O6 (tr|Q8CXW4) K07662 cpxR; two-component system, OmpR family, response regulator CpxR
B CssS-CssR (secretion stress response)
B CreC-CreB (phosphate regulation)
C KPR_0932 unnamed protein product; highly similar to putative sensor protein from Escherichia coli O157:H7 (tr|C6UQ88) K07641 creC; two-component system, OmpR family, sensor histidine kinase CreC [EC:2.7.13.3]
C KPR_0931 creC; highly similar to DNA-binding response regulator in two-component regulatory system with CreC from Escherichia coli strain B - REL606 (tr|C6UM19) K07663 creB; two-component system, OmpR family, catabolic regulation response regulator CreB
B BaeS-BaeR (envelope stress response)
C KPR_1563 baeS; highly similar to putative signal transduction histidine-protein kinase BaeS from Escherichia coli B354 (tr|D6JBX8) K07642 baeS; two-component system, OmpR family, sensor histidine kinase BaeS [EC:2.7.13.3]
C KPR_1562 baeR; highly similar to transcriptional regulatory protein BaeR from Escherichia coli strain K12 (sp|P69228) K07664 baeR; two-component system, OmpR family, response regulator BaeR
B BasS-BasR (antimicrobial peptide resistance)
C KPR_3782 basS; similar to sensor protein from Escherichia coli O157:H7 (tr|Q8XDU5) K07643 basS; two-component system, OmpR family, sensor histidine kinase BasS [EC:2.7.13.3]
C KPR_3781 basR; highly aimilar to two-component response regulator from Escherichia coli O150:H5 strain SE15 (tr|D2NFN3) K07771 basR; two-component system, OmpR family, response regulator BasR
B CusS-CusR (copper tolerance)
C KPR_0805 unnamed protein product; highly similar to C-terminal region of sensor kinase CusS from Escherichia coli B354 (tr|D6J7P2) K07644 cusS; two-component system, OmpR family, heavy metal sensor histidine kinase CusS [EC:2.7.13.3]
C KPR_0803 unnamed protein product; highly similar to putative copper resistance two-component system response regulator from Klebsiella pneumoniae NTUH-K2044 (tr|C4X2P3) K07665 cusR; two-component system, OmpR family, copper resistance phosphate regulon response regulator CusR
B QseC-QseB (quorum sensing)
C KPR_4473 qseC; highly similar to sensor protein QseC from Salmonella typhi (sp|Q8Z3P2) K07645 qseC; two-component system, OmpR family, sensor histidine kinase QseC [EC:2.7.13.3]
C KPR_4472 qseB; highly similar to transcriptional regulatory protein QseB from Salmonella typhimurium (sp|P66795) K07666 qseB; two-component system, OmpR family, response regulator QseB
B KdpD-KdpE (potassium transport)
C KPR_3865 kdpD; highly similar to sensor protein KdpD from Escherichia coli O44:H18 strain 042 - EAEC (tr|D3GXE3) K07646 kdpD; two-component system, OmpR family, sensor histidine kinase KdpD [EC:2.7.13.3]
C KPR_3866 kdpE; highly simialr to kdp operon transcriptional regulatory protein KdpE from Escherichia coli strain K12 (sp|P21866) K07667 kdpE; two-component system, OmpR family, KDP operon response regulator KdpE
B TorS-TorR (TMAO respiration)
B ArcB-ArcA (anoxic redox control)
C KPR_4811 unnamed protein product; highly similar to putative sensor protein from Escherichia coli O55:H7 strain CB9615 - EPEC (tr|D3QST0) K07648 arcB; two-component system, OmpR family, aerobic respiration control sensor histidine kinase ArcB [EC:2.7.13.3]
C KPR_0934 arcA; highly similar to ArcA transcriptional dual regulator from Escherichia coli strain UTI89 - UPEC (tr|Q1R240) K07773 arcA; two-component system, OmpR family, aerobic respiration control protein ArcA
B TctE-TctD (tricarboxylic acid transport)
B ResE-ResD (aerobic and anaerobic respiration)
B VicK-VicR (cell wall metabolism)
B MprB-MprA (maintenance of persistent infection)
B MtrB-MtrA (osmotic stress response)
B PrrB-PrrA (intracellular multiplication)
B TrcS-TrcR
B NrsS-NrsR (nickel tolerance)
B ManS-ManR (manganese homeostasis)
B NblS-NblR (photosynthesis)
B SasA-RpaAB (circadian timing mediating)
B SaeS-SaeR (staphylococcal virulence regulation)
B BceS-BceR (bacitracin transport)
B BraS-BraR (bacitracin transport)
B GraS-GraR (cationic antimicrobial peptide transport)
B YxdK-YxdJ (antimicrobial peptide response)
B ChvG-ChvI (acidity sensing)
B CiaH-CiaR
B ParS-ParR (polymyxin-adaptive resistance)
B AdeS-AdeR
B VanS-VanR (VanB type vancomycin resistance)
B VanS-VanR (VanE type vancomycin resistance)
B VanS-VanR (actinomycete type vancomycin resistance)
B ArlS-ArlR (virulence regulation)
B Ihk-Irr (virulence regulation)
B PfeS-PfeR (enterobactin-dependent iron acquisition)
B NisK-NisR (lantibiotic biosynthesis)
B Unclassified
C KPR_2422 unnamed protein product; highly similar to putative two component transcriptional regulator, winged helix family from Pantoea sp. (tr|C8Q5E8) K02483 K02483; two-component system, OmpR family, response regulator
C KPR_3691 unnamed protein product; highly similar to putative response regulator from Escherichia coli ETEC H10407 (tr|D0Z6V00) K02483 K02483; two-component system, OmpR family, response regulator
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ANarL family
B NarX-NarL (nitrate respiration)
C KPR_3134 narX; highly similar to nitrate/nitrite sensor protein NarX from Escherichia coli (tr|C3TCT7) K07673 narX; two-component system, NarL family, nitrate/nitrite sensor histidine kinase NarX [EC:2.7.13.3]
C KPR_3135 narL; highly similar to transcriptional regulator NarL from Escherichia coli FVEC1412 (tr|D6IP94) K07684 narL; two-component system, NarL family, nitrate/nitrite response regulator NarL
B NarQ-NarP (nitrate respiration)
B UhpB-UhpA (hexose phosphates uptake)
C KPR_0035 uhpB; highly similar to sensor protein UhpB from Salmonella typhimurium (sp|P27668) K07675 uhpB; two-component system, NarL family, sensor histidine kinase UhpB [EC:2.7.13.3]
C KPR_0034 uhpA; highly similar to transcriptional regulatory protein UhpA from Escherichia coli B171 (tr|B3WMN9) K07686 uhpA; two-component system, NarL family, uhpT operon response regulator UhpA
B FusK-FusR (virulence regulation)
B RcsC-RcsD-RcsB (capsule synthesis)
C KPR_2074 rcsC; highly similar to sensor protein from Escherichia coli O44:H18 strain 042 - EAEC (tr|D3H0Q8) K07677 rcsC; two-component system, NarL family, capsular synthesis sensor histidine kinase RcsC [EC:2.7.13.3]
C KPR_2076 rcsD; highly similar to phosphotransfer intermediate protein RcsD in two-component regulatory system with RcsBC from Escherichia coli O103:H2 strain 12009 - EHEC (tr|C8U6F5) K07676 rcsD; two-component system, NarL family, sensor histidine kinase RcsD [EC:2.7.13.3]
C KPR_2075 rcsB; highly similar to capsular synthesis regulator component B from Salmonella typhimurium (sp|P58663) K07687 rcsB; two-component system, NarL family, captular synthesis response regulator RcsB
B BarA-UvrY (central carbon metabolism)
C KPR_4137 barA; highly similar to putative sensor protein from Escherichia coli strain B - REL606 (tr|C6UCR0) K07678 barA; two-component system, NarL family, sensor histidine kinase BarA [EC:2.7.13.3]
B ComP-ComA (competence)
B EvgS-EvgA (acid and drug tolerance)
C KPR_4684 evgS; similar to sensor protein EvgS from Escherichia coli strain K12 (sp|P30855) K07679 evgS; two-component system, NarL family, sensor histidine kinase EvgS [EC:2.7.13.3]
C KPR_4683 evgA; highly similar to EvgA protein from Escherichia coli strain B - BL21 (tr|C5W791) K07690 evgA; two-component system, NarL family, response regulator EvgA
B DegS-DegU (multicellular behavior control)
B DesK-DesR (membrane lipid fluidity regulation)
B VraS-VraR (cell-wall peptidoglycan synthesis)
B LiaS-LiaR (cell wall stress response)
B DevS-DevR (redox response)
B NreB-NreC (dissimilatory nitrate/nitrite reduction)
B YdfH-YdfI
B SalK-SalR
B PprA–PprB (biofilm formation)
B Unclassified
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ASpo family
B KinABCDE-Spo0FA (sporulation control)
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ACitB family
B CitA-CitB (citrate fermentation)
C KPR_0978 unnamed protein product; weakly similar to sensor histidine kinase CitA from Klebsiella pneumoniae (sp|P52687) and highly similar to signal transduction histidine kinase regulating citrate-malate metabolism from Enterobacter cloacae subsp. cloacae (tr|D6DXT2) K07700 dpiB; two-component system, CitB family, cit operon sensor histidine kinase CitA [EC:2.7.13.3]
C KPR_0977 citB; highly similar to putative two-component system, response regulator CitB from Enterobacter cloacae subsp. cloacae (tr|D5CA32) K07702 dpiA; two-component system, CitB family, response regulator CitB
B CitS-CitT (magnesium-citrate transport)
B DcuS-DcuR (C4-dicarboxylate metabolism)
C KPR_2758 dcuS; similar to sensory histidine kinase DcuS in two-component regulatory system with DcuR, regulator of anaerobic fumarate respiration from Escherichia coli O111:H-strain 11128 - EHEC (tr|C8ULX3) K07701 dcuS; two-component system, CitB family, sensor histidine kinase DcuS [EC:2.7.13.3]
C KPR_2759 dcuR; similar to putative two-component response regulator from Escherichia coli O44:H18 strain 042 - EAEC (tr|D3GU02) K07703 dcuR; two-component system, CitB family, response regulator DcuR
B DctS-DctR (C4-dicarboxylate transport)
B MalK-MalR (malate transport)
B Unclassified
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ALytTR family
B LysS-LysR
B AlgZ-AlgR (alginate production)
B NatK-NatR (sodium extrusion)
B AgrC-AgrA (exoprotein synthesis)
B AgrC2-AgrA2 (virulence regulation)
B ComD-ComE (competence)
B Unclassified
C KPR_1535 unnamed protein product; highly similar to middle region of putative signal transduction histidine kinase, LytS from Enterobacter cloacae (tr|E3GC44) K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C KPR_1968 ypdA; highly similar to inner membrane protein YpdA from Escherichia coli strain K12 (sp|P0AA93) K02478 K02478; two-component system, LytTR family, sensor kinase [EC:2.7.13.3]
C KPR_1537 yehT; highly similar to uncharacterized response regulatory protein YehT from Shigella flexneri (sp|P59640) K02477 K02477; two-component system, LytTR family, response regulator
C KPR_1967 ypdB; highly similar to putative response regulator in two-component system with YpdA from Escherichia coli O45:K1 strain S88 - ExPEC (tr|B7MH41) K02477 K02477; two-component system, LytTR family, response regulator
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ANtrC family
B GlnL-GlnG (nitrogen regulation)
C KPR_0137 ntrB; highly similar to nitrogen regulation protein NtrB from Klebsiella oxytoca (sp|P06218) K07708 glnL; two-component system, NtrC family, nitrogen regulation sensor histidine kinase GlnL [EC:2.7.13.3]
C KPR_0136 ntrC; highly similar to nitrogen assimilation regulatory protein from Klebsiella pneumoniae (sp|P03029) K07712 glnG; two-component system, NtrC family, nitrogen regulation response regulator GlnG
B NtrY-NtrX (nitrogen regulation)
B HydH-HydG (metal tolerance)
C KPR_0322 unnamed protein product; highly similar to N-terminal region of sensor protein ZraS from Klebsiella oxytoca (sp|Q9APE0) K07709 zraS; two-component system, NtrC family, sensor histidine kinase HydH [EC:2.7.13.3]
C KPR_0324 zraR; highly similar to transcriptional regulatory protein ZraR from Klebsiella oxytoca (sp|Q9APD9) K07713 zraR; two-component system, NtrC family, response regulator HydG
B AtoS-AtoC (cPHB biosynthesis)
B PilS-PilR (type 4 fimbriae synthesis)
B GlrK-GlrR (amino sugar metabolism)
C KPR_1392 unnamed protein product; highly similar to sensor protein from Escherichia coli O111:H-(tr|B3Y152) K07711 glrK; two-component system, NtrC family, sensor histidine kinase GlrK [EC:2.7.13.3]
C KPR_1394 yfhA; highly similar to uncharacterized protein YfhA from Escherichia coli strain K12 (sp|P0AFU4) K07715 glrR; two-component system, NtrC family, response regulator GlrR
B PgtB-PgtA (phosphoglycerate transport)
B DctB-DctD (C4-dicarboxylate transport)
B KinB-AlgB (alginate production)
B HupT-HupR (hydrogenase synthesis regulation)
B Unclassified
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ACheA family
B CheA-CheYBV (chemotaxis)
B ChpA-ChpB/PilGH (chemosensory)
B PixL-PixGH (positive phototaxis)
B WspE-WspRF (chemosensory)
B Cph1-Rcp1 (light response)
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ACell cycle family
B PleC-PleD (cell fate control)
B CckA-CtrA/CpdR (cell cycle control)
B Hk1-Rrp1 (glycerol uptake and utilization)
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ALux family
B LuxQN/CqsS-LuxU-LuxO (quorum sensing)
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ALuxR family
B DctS-DctR (C4-dicarboxylate transport)
B TtrS-TtrR (tetrathionate respiration)
B FixL-FixJ (nitrogen fixation)
B SsrA-SsrB
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AOther families
B FlrB-FlrC (polar flagellar synthesis)
B AauS-AauR (acidic amino acids utilization)
B SLN1-YPD1-SSK1/SKN7 (osmosensing)
B RpfC-RpfG (cell-to-cell signaling)
B GlnK-GlnL (glutamine utilization)
B HspS-HspR (hexose phosphates uptake)
B YesM-YesN
B CikA
B RegB-RegA (redox response)
B FitF-FitH (insecticidal toxin regulation)
B PhcS-PhcRQ
B SagS-HptB-HsbR (swarming activity and biofilm formation)
B PdtaS-PdtaR
B NasS-NasT
B Unclassified
C KPR_3122 rpoS; highly similar to response regulator of RpoS from Escherichia coli O111:H-strain 11128 - EHEC (tr|C8UNZ0) K02485 rssB; two-component system, response regulator
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: December 14, 2023