+E Replication protein KO
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DNA Replication Proteins - Lates calcarifer (barramundi perch)
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AEukaryotic type
B DNA Replication Initiation Factors
C pre-RC (pre-replication complex)
D 108883334 origin recognition complex subunit 1 K02603 ORC1; origin recognition complex subunit 1
D 108892219 LOW QUALITY PROTEIN: origin recognition complex subunit 1-like K02603 ORC1; origin recognition complex subunit 1
D 108883899 origin recognition complex subunit 2 K02604 ORC2; origin recognition complex subunit 2
D 108875030 LOW QUALITY PROTEIN: origin recognition complex subunit 3 K02605 ORC3; origin recognition complex subunit 3
D 108873089 origin recognition complex subunit 4 K02606 ORC4; origin recognition complex subunit 4
D 108886204 origin recognition complex subunit 5 isoform X1 K02607 ORC5; origin recognition complex subunit 5
D 108894850 DNA replication factor Cdt1 K10727 CDT1; chromatin licensing and DNA replication factor 1
D 108882499 cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 108891856 LOW QUALITY PROTEIN: cell division control protein 6 homolog K02213 CDC6; cell division control protein 6
D 108901495 DNA replication licensing factor MCM2 K02540 MCM2; DNA replication licensing factor MCM2 [EC:5.6.2.3]
D 108895828 DNA replication licensing factor MCM3 K02541 MCM3; DNA replication licensing factor MCM3 [EC:5.6.2.3]
D 108883375 DNA replication licensing factor MCM4 K02212 MCM4; DNA replication licensing factor MCM4 [EC:5.6.2.3]
D 108898656 DNA replication licensing factor MCM5 K02209 MCM5; DNA replication licensing factor MCM5 [EC:5.6.2.3]
D 108883887 DNA replication licensing factor MCM6 K02542 MCM6; DNA replication licensing factor MCM6 [EC:5.6.2.3]
D 108895074 DNA replication licensing factor MCM7 isoform X1 K02210 MCM7; DNA replication licensing factor MCM7 [EC:5.6.2.3]
C CDK (cyclin dependent kinase)
D 108893870 cyclin-A1 isoform X3 K06627 CCNA; cyclin-A
D 108901509 cyclin-A2 K06627 CCNA; cyclin-A
D 108894340 G1/S-specific cyclin-E1 K06626 CCNE; G1/S-specific cyclin-E1
D 108884668 ccne2; G1/S-specific cyclin-E2 K06626 CCNE; G1/S-specific cyclin-E1
D 108899042 G1/S-specific cyclin-E2 K06626 CCNE; G1/S-specific cyclin-E1
D 108898963 LOW QUALITY PROTEIN: cyclin-dependent kinase 2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
D 108886434 cyclin-dependent kinase 2 K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
C DDK (Dbf-4 dependent kinase)
D 108883712 cell division cycle 7-related protein kinase isoform X1 K02214 CDC7; cell division control protein 7 [EC:2.7.11.1]
D 108889581 protein DBF4 homolog A K06629 DBF4; protein DBF4
D 108898738 dbf4b; uncharacterized protein dbf4b K06629 DBF4; protein DBF4
C GINS complex
D 108873851 DNA replication complex GINS protein PSF1 K10732 GINS1; GINS complex subunit 1
D 108877756 DNA replication complex GINS protein PSF2 K10733 GINS2; GINS complex subunit 2
D 108902340 DNA replication complex GINS protein PSF3 K10734 GINS3; GINS complex subunit 3
D 108878711 DNA replication complex GINS protein SLD5 K10735 GINS4; GINS complex subunit 4
C Other initiation factors
D 108900032 LOW QUALITY PROTEIN: DNA topoisomerase 2-binding protein 1 K10728 TOPBP1; topoisomerase (DNA) II binding protein 1
D 108879470 LOW QUALITY PROTEIN: ATP-dependent DNA helicase Q4 K10730 RECQL4; ATP-dependent DNA helicase Q4 [EC:5.6.2.4]
D 108881759 cell division control protein 45 homolog K06628 CDC45; cell division control protein 45
D 108872942 LOW QUALITY PROTEIN: DNA helicase MCM8 K10737 MCM8; DNA helicase MCM8 [EC:5.6.2.4]
D 108899342 DNA helicase MCM9 K10738 MCM9; DNA helicase MCM9 [EC:5.6.2.4]
D 108874302 protein MCM10 homolog isoform X1 K10736 MCM10; minichromosome maintenance protein 10
D 108893494 serine protease FAM111A K24274 FAM111A; protein FAM111A
D 108902349 serine protease FAM111A K24274 FAM111A; protein FAM111A
D 108891606 cyclin-dependent kinase 2-interacting protein K26052 CINP; cyclin-dependent kinase 2-interacting protein
D 108889415 mdm2-binding protein isoform X1 K26116 MTBP; Mdm2-binding protein
D 108889289 LOW QUALITY PROTEIN: treslin K26117 TICRR; Treslin
B DNA Replication Elongation Factors
C DNA polymerase alpha / primase complex
D 108902051 LOW QUALITY PROTEIN: DNA polymerase alpha catalytic subunit K02320 POLA1; DNA polymerase alpha subunit A [EC:2.7.7.7]
D 108899096 DNA polymerase alpha subunit B K02321 POLA2; DNA polymerase alpha subunit B
D 108900240 DNA primase small subunit K02684 PRI1; DNA primase small subunit [EC:2.7.7.102]
D 108892390 LOW QUALITY PROTEIN: DNA primase large subunit K02685 PRI2; DNA primase large subunit
C DNA polymerase epsilon complex
D 108878119 DNA polymerase epsilon catalytic subunit A K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
D 108874849 LOW QUALITY PROTEIN: DNA polymerase epsilon subunit 2 K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
D 108894290 DNA polymerase epsilon subunit 3 K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
D 108881386 DNA polymerase epsilon subunit 4 K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
C DNA polymerase delta complex
D 108881005 LOW QUALITY PROTEIN: DNA polymerase delta catalytic subunit K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
D 108878227 DNA polymerase delta subunit 2 K02328 POLD2; DNA polymerase delta subunit 2
D 108884349 DNA polymerase delta subunit 3 isoform X1 K03504 POLD3; DNA polymerase delta subunit 3
D 108888449 DNA polymerase delta subunit 4 K03505 POLD4; DNA polymerase delta subunit 4
C DNA polymerase gamma complex (mitochondrial)
D 108875308 LOW QUALITY PROTEIN: DNA polymerase subunit gamma-1 K02332 POLG; DNA polymerase gamma 1 [EC:2.7.7.7]
D 108875956 LOW QUALITY PROTEIN: DNA polymerase subunit gamma-2, mitochondrial K02333 POLG2; DNA polymerase gamma 2
C RPA (replication protein A)
D 108893926 replication protein A 70 kDa DNA-binding subunit isoform X1 K07466 RFA1; replication factor A1
D 108875967 rpa1; replication protein A 70 kDa DNA-binding subunit K07466 RFA1; replication factor A1
D 108898696 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D 108900292 replication protein A 32 kDa subunit K10739 RFA2; replication factor A2
D 108896197 replication protein A 14 kDa subunit K10740 RPA3; replication factor A3
C RFC (replication factor C)
D 108896614 replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
D 108883146 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 108896976 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 108902774 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 108893286 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C RNase H
D 108872452 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D 108875931 LOW QUALITY PROTEIN: ribonuclease H2 subunit A K10743 RNASEH2A; ribonuclease H2 subunit A [EC:3.1.26.4]
D 108901304 ribonuclease H2 subunit B isoform X1 K10744 RNASEH2B; ribonuclease H2 subunit B
D 108872566 ribonuclease H2 subunit C K10745 RNASEH2C; ribonuclease H2 subunit C
C Other elongation factors
D 108881922 proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
D 108876918 DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
D 108899945 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 108883728 zgc:110269; probable flap endonuclease 1 homolog K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
D 108884804 LOW QUALITY PROTEIN: exonuclease 1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
D 108900642 DNA annealing helicase and endonuclease ZRANB3 K25861 ZRANB3; DNA annealing helicase and endonuclease ZRANB3 [EC:5.6.2.- 3.1.-.-]
D 108884325 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D 108875802 LOW QUALITY PROTEIN: ATPase family AAA domain-containing protein 5b K26118 ATAD5; ATPase family AAA domain-containing protein 5
D 108880399 LOW QUALITY PROTEIN: ATPase family AAA domain-containing protein 5 K26118 ATAD5; ATPase family AAA domain-containing protein 5
B DNA Replication Termination Factors
C DNA methylation enzymes
D 108902999 DNA (cytosine-5)-methyltransferase 1 K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37]
D 108888898 LOW QUALITY PROTEIN: DNA (cytosine-5)-methyltransferase 3A-like K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
D 108902000 dnmt3ab; DNA (cytosine-5)-methyltransferase 3A isoform X1 K17398 DNMT3A; DNA (cytosine-5)-methyltransferase 3A [EC:2.1.1.37]
D 108873305 LOW QUALITY PROTEIN: uncharacterized protein LOC108873305 K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
D 108873297 dnmt3bb.1; DNA (cytosine-5)-methyltransferase 3B isoform X1 K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
D 108890497 dnmt3ba; DNA (cytosine-5-)-methyltransferase 3 beta, duplicate a isoform X1 K17399 DNMT3B; DNA (cytosine-5)-methyltransferase 3B [EC:2.1.1.37]
C Prevention of re-replication factors
D 108898113 geminin K10749 GMNN; geminin
D 108881274 multicilin K26119 MCIDAS; multicilin
D 108889030 G2/mitotic-specific cyclin-B1 isoform X1 K05868 CCNB1; G2/mitotic-specific cyclin-B1
D 108894316 LOW QUALITY PROTEIN: G2/mitotic-specific cyclin-B2-like K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 108894246 G2/mitotic-specific cyclin-B2 isoform X1 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 108898800 ccnp; cyclin N-terminal domain-containing protein 2 K21770 CCNB2; G2/mitotic-specific cyclin-B2
D 108902096 G2/mitotic-specific cyclin-B3 K21771 CCNB3; G2/mitotic-specific cyclin-B3
D 108895329 cyclin-dependent kinase 1 isoform X1 K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
C Telomere proteins
D Shelterin complex
E 108903090 LOW QUALITY PROTEIN: protection of telomeres protein 1 K11109 POT1; protection of telomeres protein 1
E 108881813 LOW QUALITY PROTEIN: telomeric repeat-binding factor 1 K11110 TERF1; telomeric repeat-binding factor 1
E 108876977 terfa; telomeric repeat binding factor a K11111 TERF2; telomeric repeat-binding factor 2
E 108903037 tinf2; TERF1-interacting nuclear factor 2 K11112 TINF2; TERF1-interacting nuclear factor 2
E 108890092 telomeric repeat-binding factor 2-interacting protein 1 K11113 TERF2IP; telomeric repeat-binding factor 2-interacting protein 1
E 108902242 acd; adrenocortical dysplasia protein homolog K11114 ACD; adrenocortical dysplasia protein
D TERB1-TERB2-MAJIN complex
E 108875118 telomere repeats-binding bouquet formation protein 1 K25749 TERB1; telomere repeats-binding bouquet formation protein 1
E 108889653 telomere repeats-binding bouquet formation protein 2 K25750 TERB2; telomere repeats-binding bouquet formation protein 2
E 108888775 uncharacterized protein LOC108888775 isoform X1 K25751 MAJIN; membrane-anchored junction protein
D CST complex (animals)
E 108882199 LOW QUALITY PROTEIN: CST complex subunit CTC1-like K23311 CTC1; CST complex subunit CTC1
E 108882333 CST complex subunit CTC1 isoform X2 K23311 CTC1; CST complex subunit CTC1
E 108884511 CST complex subunit STN1 K23312 STN1; CST complex subunit STN1
E 108875871 CST complex subunit TEN1 K23313 TEN1; CST complex subunit TEN1
D CST complex (yeast)
D RIF proteins
D SIR proteins
C Telomerase complex (animals)
D 108893430 telomerase-binding protein EST1A K11124 SMG6; protein SMG6 [EC:3.1.-.-]
D 108899466 nonsense-mediated mRNA decay factor SMG5 K11125 SMG5; protein SMG5
D 108900386 telomerase reverse transcriptase isoform X1 K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D 108884289 telomerase protein component 1 K11127 TEP1; telomerase protein component 1
D Dyskerin complex
E 108885169 H/ACA ribonucleoprotein complex subunit 1 K11128 GAR1; H/ACA ribonucleoprotein complex subunit 1
E 108884078 H/ACA ribonucleoprotein complex subunit 2-like protein isoform X1 K11129 NHP2; H/ACA ribonucleoprotein complex subunit 2
E 108890750 H/ACA ribonucleoprotein complex subunit 3 K11130 NOP10; H/ACA ribonucleoprotein complex subunit 3
E 108891603 H/ACA ribonucleoprotein complex subunit DKC1 isoform X1 K11131 DKC1; H/ACA ribonucleoprotein complex subunit 4 [EC:5.4.99.-]
C Telomerase complex (fungi)
D 108900386 telomerase reverse transcriptase isoform X1 K11126 TERT; telomerase reverse transcriptase [EC:2.7.7.49]
D Sm core complex
E 108890716 small nuclear ribonucleoprotein-associated proteins B and B' isoform X1 K11086 SNRPB; small nuclear ribonucleoprotein B and B'
E 108898170 small nuclear ribonucleoprotein Sm D1 K11087 SNRPD1; small nuclear ribonucleoprotein D1
E 108879417 small nuclear ribonucleoprotein Sm D2 K11096 SNRPD2; small nuclear ribonucleoprotein D2
E 108879194 snrpd3l; small nuclear ribonucleoprotein D3 polypeptide, like K11088 SNRPD3; small nuclear ribonucleoprotein D3
E 108877526 small nuclear ribonucleoprotein E K11097 SNRPE; small nuclear ribonucleoprotein E
E 108897575 small nuclear ribonucleoprotein F K11098 SNRPF; small nuclear ribonucleoprotein F
E 108885161 snrpg; small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
E 108887621 small nuclear ribonucleoprotein G K11099 SNRPG; small nuclear ribonucleoprotein G
C ELG1-RFC complex
D 108883146 replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D 108896976 replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D 108902774 replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D 108893286 replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
C MRN complex
D 108895263 mre11a; LOW QUALITY PROTEIN: double-strand break repair protein MRE11 K10865 MRE11; double-strand break repair protein MRE11
D 108893689 DNA repair protein RAD50 K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D 108889580 nibrin K10867 NBN; nibrin
C Other termination factors
D 108873779 LOW QUALITY PROTEIN: serine-protein kinase ATM K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D 108875432 recQ-like DNA helicase BLM isoform X1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D 108898307 LOW QUALITY PROTEIN: DNA-dependent protein kinase catalytic subunit K06642 PRKDC; DNA-dependent protein kinase catalytic subunit [EC:2.7.11.1]
D 108889141 DNA repair endonuclease XPF K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
D 108895621 poly [ADP-ribose] polymerase 1 K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
D 108872815 protein mono-ADP-ribosyltransferase PARP4 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 108886443 parp3; protein mono-ADP-ribosyltransferase PARP3 isoform X1 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 108884291 poly [ADP-ribose] polymerase 2 K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
D 108878510 poly [ADP-ribose] polymerase tankyrase-1 isoform X1 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 108886055 tnksa; poly [ADP-ribose] polymerase tankyrase-2 K10799 TNKS; tankyrase [EC:2.4.2.30]
D 108876819 LOW QUALITY PROTEIN: poly [ADP-ribose] polymerase tankyrase-2-like K10799 TNKS; tankyrase [EC:2.4.2.30]
D 108895574 LOW QUALITY PROTEIN: PIN2/TERF1-interacting telomerase inhibitor 1 K11135 PINX1; Pin2-interacting protein X1
D 108900463 regulator of telomere elongation helicase 1 isoform X3 K11136 RTEL1; regulator of telomere elongation helicase 1 [EC:5.6.2.3]
D 108886784 telomere length regulation protein TEL2 homolog K11137 TELO2; telomere length regulation protein
D 108898629 trir; telomerase RNA component interacting RNase K01149 TRIR; telomerase RNA component interacting RNase [EC:3.1.13.-]
D 108888102 LOW QUALITY PROTEIN: telomere-associated protein RIF1-like K11138 RIF1; telomere-associated protein RIF1
D 108902469 LOW QUALITY PROTEIN: telomere-associated protein RIF1 K11138 RIF1; telomere-associated protein RIF1
D 108883693 ATP-dependent DNA helicase PIF1 K15255 PIF1; ATP-dependent DNA helicase PIF1 [EC:5.6.2.3]
D 108878736 transcriptional activator protein Pur-alpha K21772 PURA; transcriptional activator protein Pur-alpha
D 108893437 puraa; purine-rich element binding protein Aa K21772 PURA; transcriptional activator protein Pur-alpha
D 108877694 purine-rich element-binding protein gamma K21800 PURG; purine-rich element-binding protein gamma
D 108902168 telomerase Cajal body protein 1 K23314 WRAP53; telomerase Cajal body protein 1
D 108882302 replication stress response regulator SDE2 isoform X1 K25059 SDE2; replication stress response regulator SDE2
D 108902115 rtf2; replication termination factor 2 K25186 RTF2; replication termination factor 2
B DNA Topoisomerases
C 108885596 LOW QUALITY PROTEIN: DNA topoisomerase I, like K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 108877950 top1b; DNA topoisomerase 1 K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 108901910 zgc:173742; DNA topoisomerase I, mitochondrial K03163 TOP1; DNA topoisomerase I [EC:5.6.2.1]
C 108900254 DNA topoisomerase 2-beta isoform X1 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 108875718 DNA topoisomerase 2-alpha isoform X2 K03164 TOP2; DNA topoisomerase II [EC:5.6.2.2]
C 108877670 LOW QUALITY PROTEIN: DNA topoisomerase 3-alpha K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
C 108878668 DNA topoisomerase 3-beta-1 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
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AProkaryotic type
B DNA Replication Initiation Factors
C Initiation factors (bacterial)
D 108897587 single-stranded DNA-binding protein, mitochondrial K03111 ssb; single-strand DNA-binding protein
C Initiation factors (archaeal)
B DNA Replication Elongation Factors
C Elongation factors (bacterial)
D DNA polymerase III holoenzyme
D RNase H
E 108872452 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D Other elongation factors
C Elongation factors (archaeal)
D B-family DNA polymerases
D D-family DNA polymerases
D RNase H
E 108872452 ribonuclease H1 K03469 rnhA; ribonuclease HI [EC:3.1.26.4]
D RFC (replication factor C)
D Other elongation factors
E 108876918 DNA replication ATP-dependent helicase/nuclease DNA2 K10742 DNA2; DNA replication ATP-dependent helicase/nuclease Dna2 [EC:5.6.2.3 3.1.-.-]
E 108899945 flap endonuclease 1 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 108883728 zgc:110269; probable flap endonuclease 1 homolog K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E 108884325 DNA ligase 1 isoform X1 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
B DNA Replication Termination Factors
C Terminus site-binding protein
C DNA methylation enzymes
C Prevention of re-replication factors
B DNA Topoisomerases
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: November 2, 2022