+E Ubiquitin system KO
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Ubiquitin System - Leishmania donovani
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AUbiquitins and ubiquitin-like proteins
B Ubiquitins
C LDBPK_311930 ubiquitin-fusion protein K02927 RP-L40e; ubiquitin-large subunit ribosomal protein L40e
C LDBPK_360660 ubiquitin/ribosomal protein S27a, putative K02977 RP-S27Ae; ubiquitin-small subunit ribosomal protein S27Ae
B Ubiquitin-like proteins (UBLs)
C LDBPK_341880 ubiquitin-like protein K12158 NEDD8; ubiquitin-like protein Nedd8
C LDBPK_300710 40S ribosomal protein S30, putative K02983 RP-S30e; small subunit ribosomal protein S30e
C LDBPK_300690 40S ribosomal protein S30, putative K02983 RP-S30e; small subunit ribosomal protein S30e
C LDBPK_191660 ATG8/AUT7/APG8/PAZ2, putative K08341 GABARAP; GABA(A) receptor-associated protein
C LDBPK_190840 ATG8/AUT7/APG8/PAZ2, putative K08341 GABARAP; GABA(A) receptor-associated protein
C LDBPK_342690 ubiquitin related modifier (urm1)-like protein K12161 URM1; ubiquitin related modifier 1
C LDBPK_161100 hypothetical protein K12162 UFM1; ubiquitin-fold modifier 1
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AUbiquitin-activating enzymes (E1)
B Ubiquitin activating enzyme
C LDBPK_353110 ubiquitin-activating enzyme E1, putative K03178 UBE1; ubiquitin-activating enzyme E1 [EC:6.2.1.45]
C LDBPK_230710 ubiquitin-activating enzyme E1, putative K03178 UBE1; ubiquitin-activating enzyme E1 [EC:6.2.1.45]
B UBL-activating enzymes
C LDBPK_280500 ubiquitin activating enzyme, putative K10684 UBLE1A; ubiquitin-like 1-activating enzyme E1 A [EC:6.2.1.45]
C LDBPK_080230 ubiquitin-activating enzyme-like protein K10685 UBLE1B; ubiquitin-like 1-activating enzyme E1 B [EC:6.2.1.45]
C LDBPK_271570 molybdopterin synthase sulphurylase-like protein, putative K11996 MOCS3; adenylyltransferase and sulfurtransferase [EC:2.7.7.80 2.8.1.11]
C LDBPK_151030 NAD/FAD dependent dehydrogenase, putative K12164 UBA5; ubiquitin-like modifier-activating enzyme 5
C LDBPK_070010 ubiquitin activating E1 enzyme, putative K08337 ATG7; ubiquitin-like modifier-activating enzyme ATG7
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AUbiquitin-conjugating enzymes (E2)
B Ubiquitin-conjugating enzymes
C LDBPK_220480 ubiquitin-conjugating enzyme-like protein K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
C LDBPK_242220 ubiquitin-conjugating enzyme E2, putative K06688 UBE2C; ubiquitin-conjugating enzyme E2 C [EC:2.3.2.23]
C LDBPK_351310 ubiquitin-conjugating enzyme E2, putative K06689 UBE2D; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]
C LDBPK_320730 ubiquitin carrier protein 4, putative K10576 UBE2H; ubiquitin-conjugating enzyme E2 H [EC:2.3.2.23]
C LDBPK_340950 ubiquitin-conjugating enzyme E2, putative K04554 UBE2J2; ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23]
C LDBPK_040680 ubiquitin-conjugating enzyme E2, putative K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C LDBPK_321010 ubiquitin-conjugating enzyme protein, putative K02207 UBE2R; ubiquitin-conjugating enzyme E2 R [EC:2.3.2.23]
C LDBPK_332910 ubiquitin-conjugating enzyme, putative K10583 UBE2S; ubiquitin-conjugating enzyme E2 S [EC:2.3.2.23]
C LDBPK_071000 ubiquitin-conjugating enzyme E2, putative K10689 PEX4; peroxin-4 [EC:2.3.2.23]
B UBL-conjugating enzymes
C LDBPK_020360 ubiquitin-conjugating enzyme E2, putative K10577 UBE2I; ubiquitin-conjugating enzyme E2 I
C LDBPK_241780 ubiquitin-conjugating enzyme E2, putative K10579 UBE2M; ubiquitin-conjugating enzyme E2 M [EC:2.3.2.34]
C LDBPK_330320 autophagocytosis protein, putative K08343 ATG3; ubiquitin-like-conjugating enzyme ATG3
C LDBPK_151270 hypothetical protein K12165 UFC1; ufm1-conjugating enzyme 1
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AUbiquitin ligases (E3)
B HECT type E3
C LDBPK_352500 hypothetical protein K10590 TRIP12; E3 ubiquitin-protein ligase TRIP12 [EC:2.3.2.26]
C LDBPK_321150 hypothetical protein K10590 TRIP12; E3 ubiquitin-protein ligase TRIP12 [EC:2.3.2.26]
C LDBPK_343790 hypothetical protein K03874 HECT; other hect domain ubiquitin protein ligase E3 [EC:2.3.2.26]
C LDBPK_364580 hypothetical protein K03874 HECT; other hect domain ubiquitin protein ligase E3 [EC:2.3.2.26]
C LDBPK_364590 hypothetical protein K03874 HECT; other hect domain ubiquitin protein ligase E3 [EC:2.3.2.26]
C HECT type E3 associated proteins
B U-box type E3
C LDBPK_272430 hypothetical protein K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
B Single Ring-finger type E3
C BRE1 proteins
C CBL proteins
C SINA (Seven in absentia) proteins
C Ligand of Numb proteins
C March proteins
C MDM2/MDM4 proteins
C NFX1 proteins
D LDBPK_220007 transcription factor-like protein K12236 NFX1; transcriptional repressor NF-X1
C Pellino proteins
C Peripheral membrane proteins
D LDBPK_252400 hypothetical protein K13346 PEX10; peroxin-10
D LDBPK_191240 peroxisome assembly protein, putative K13345 PEX12; peroxin-12
D LDBPK_252330 glycosome import protein K06664 PEX2; peroxin-2
C RBR proteins
C TRAF proteins
C TRIM/RBCC proteins
C UBR box proteins
C ATL proteins
C Other single Ring-finger type E3
D LDBPK_240290 hypothetical protein K22377 LTN1; E3 ubiquitin-protein ligase listerin [EC:2.3.2.27]
D LDBPK_281410 hypothetical protein K15708 RNF180; E3 ubiquitin-protein ligase RNF180 [EC:2.3.2.27]
D LDBPK_151460 hypothetical protein K10601 SYVN1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27]
D LDBPK_301290 hypothetical protein K22381 ZNF598; E3 ubiquitin-protein ligase ZNF598 [EC:2.3.2.27]
B Atypical E3
B UBL E3 ligases
C LDBPK_210040 ring-box protein 1, putative K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
C LDBPK_241680 ring-box protein, putative K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
C LDBPK_130230 hypothetical protein K25662 RNF212; E3 SUMO-protein ligase RNF212 [EC:2.3.2.-]
C LDBPK_367120 hypothetical protein K22755 UFL1; E3 UFM1-protein ligase 1 [EC:2.3.2.-]
C LDBPK_344100 hypothetical protein K17822 DCUN1D1_2; DCN1-like protein 1/2
B Multi subunit Ring-finger type E3
C SCF complex
D Ring finger protein
E LDBPK_210040 ring-box protein 1, putative K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
E LDBPK_241680 ring-box protein, putative K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adaptor protein
E LDBPK_111200 S-phase kinase-associated protein, putative K03094 SKP1; S-phase kinase-associated protein 1
D Target recognizing subunit (F-box)
C Cul2 complex
D Ring finger protein
E LDBPK_210040 ring-box protein 1, putative K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
E LDBPK_241680 ring-box protein, putative K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adoptor protein
D Target recognizing subunit
C Cul3 complex
D Ring finger protein
E LDBPK_210040 ring-box protein 1, putative K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
E LDBPK_241680 ring-box protein, putative K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adoptor and target recognizing subunit (BTB)
C Cul4 complex
D Ring finger protein
E LDBPK_210040 ring-box protein 1, putative K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
E LDBPK_241680 ring-box protein, putative K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adoptor protein
D Target recognizing subunit (DCAF)
E LDBPK_331880 hypothetical protein K11789 DCAF1; DDB1- and CUL4-associated factor 1 [EC:2.7.11.1]
E LDBPK_355240 hypothetical protein K11805 DCAF7; DDB1- and CUL4-associated factor 7
E LDBPK_353920 hypothetical protein K11806 DCAF13; DDB1- and CUL4-associated factor 13
C Cul5 complex
D Ring finger protein
D Cullin
D Adoptor protein
D Target recognizing subunit
C Cul7 complex
D Ring finger protein
E LDBPK_210040 ring-box protein 1, putative K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
E LDBPK_241680 ring-box protein, putative K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adaptor protein
E LDBPK_111200 S-phase kinase-associated protein, putative K03094 SKP1; S-phase kinase-associated protein 1
D Target recognizing subunit
C Cul8 complex
D Ring finger protein
E LDBPK_210040 ring-box protein 1, putative K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
E LDBPK_241680 ring-box protein, putative K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adaptor protein
D Target recognizing subunit
C Cul9 complex
D Ring finger protein
E LDBPK_210040 ring-box protein 1, putative K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
E LDBPK_241680 ring-box protein, putative K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
C APC/C
D Ring finger protein
E LDBPK_160650 hypothetical protein K03358 APC11; anaphase-promoting complex subunit 11
E LDBPK_354570 anaphase promoting complex subunit protein, putative K03358 APC11; anaphase-promoting complex subunit 11
D Cullin
E LDBPK_353800 hypothetical protein K03349 APC2; anaphase-promoting complex subunit 2
D Target recognizing subunit
D Other subunits
E LDBPK_301990 cyclosome subunit-like protein K03348 APC1; anaphase-promoting complex subunit 1
E LDBPK_300740 CDC16, putative K03353 APC6; anaphase-promoting complex subunit 6
E LDBPK_120560 hypothetical protein K03355 APC8; anaphase-promoting complex subunit 8
E LDBPK_040380 anaphase promoting complex, subunit 10-like protein K03357 APC10; anaphase-promoting complex subunit 10
C BRCC complex
D LDBPK_262450 metallopeptidase, putative K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D LDBPK_280580 RAD51 protein, putative K04482 RAD51; DNA repair protein RAD51
C KPC complex
C LUBAC complex
C CTLH complex
C ERAD complex
C LMBR1L-GP78-UBAC2 complex
C SLX5-SLX8 complex
C Multi subunit type E3 associated proteins
D LDBPK_270320 hypothetical protein K17263 CAND1; cullin-associated NEDD8-dissociated protein 1
D LDBPK_030320 hypothetical protein K23344 DDRGK1; DDRGK domain-containing protein 1
D LDBPK_252300 hypothetical protein K26163 PACRG; parkin coregulated gene protein
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ADeubiquitinating enzyme (DUB)
B Ubiquitin-specific proteases (UBPs)
C UCH
D LDBPK_250190 ubiquitin carboxyl-terminal hydrolase, putative K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
D LDBPK_240420 ubiquitin carboxyl-terminal hydrolase, putative K05610 UCHL5; ubiquitin carboxyl-terminal hydrolase L5 [EC:3.4.19.12]
C UBP/USP
D LDBPK_271170 ubiquitin hydrolase, putative K11833 USP2; ubiquitin carboxyl-terminal hydrolase 2 [EC:3.4.19.12]
D LDBPK_323060 ubiquitin hydrolase, putative K11835 USP4_11; ubiquitin carboxyl-terminal hydrolase 4/11 [EC:3.4.19.12]
D LDBPK_292410 ubiquitin hydrolase, putative K11836 USP5_13; ubiquitin carboxyl-terminal hydrolase 5/13 [EC:3.4.19.12]
D LDBPK_343890 ubiquitin hydrolase, putative K11838 USP7; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]
D LDBPK_351730 ubiquitin hydrolase, putative K11838 USP7; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]
D LDBPK_321310 ubiquitin hydrolase, putative K11841 USP10; ubiquitin carboxyl-terminal hydrolase 10 [EC:3.4.19.12]
D LDBPK_210460 ubiquitin hydrolase, putative K11842 USP12_46; ubiquitin carboxyl-terminal hydrolase 12/46 [EC:3.4.19.12]
D LDBPK_310150 ubiquitin hydrolase, putative K11843 USP14; ubiquitin carboxyl-terminal hydrolase 14 [EC:3.4.19.12]
D LDBPK_090390 ubiqitin hydrolase, putative K11848 USP20_33; ubiquitin carboxyl-terminal hydrolase 20/33 [EC:3.4.19.12]
D LDBPK_120170 ubiquitin hydrolase, putative K11854 USP35_38; ubiquitin carboxyl-terminal hydrolase 35/38 [EC:3.4.19.12]
D LDBPK_240630 ubiquitin hydrolase, putative K11855 USP36_42; ubiquitin carboxyl-terminal hydrolase 36/42 [EC:3.4.19.12]
D LDBPK_160730 ubiquitin hydrolase, putative K11858 USP48; ubiquitin carboxyl-terminal hydrolase 48 [EC:3.4.19.12]
C OTU
D LDBPK_171520 otubain, putative K09602 OTUB1; ubiquitin thioesterase protein OTUB1 [EC:3.4.19.12]
C MJD
C MINDY
D LDBPK_352060 hypothetical protein K22647 MINDY3_4; ubiquitin carboxyl-terminal hydrolase MINDY-3/4 [EC:3.4.19.12]
C JAMM
D LDBPK_262450 metallopeptidase, putative K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D LDBPK_340670 proteasome regulatory non-ATP-ase subunit 11, putative K03030 PSMD14; 26S proteasome regulatory subunit N11
C PPPDE
C ZUFSP
C BRISC complex
D LDBPK_262450 metallopeptidase, putative K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
B UBL-specific proteases (ULPs)
C LDBPK_250190 ubiquitin carboxyl-terminal hydrolase, putative K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
C COP9 signalosome (CSN) complex
D LDBPK_252310 hypothetical protein K12176 COPS2; COP9 signalosome complex subunit 2
D LDBPK_160850 metallopeptidase, putative K09613 COPS5; COP9 signalosome complex subunit 5 [EC:3.4.-.-]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: April 5, 2024