+F Repair protein KO
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DNA Repair and Recombination Proteins - Methylotuvimicrobium alcaliphilum
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D MEALZ_0760 Methylated-DNA/protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D MEALZ_0376 phr; deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E MEALZ_2632 Uracil-DNA glycosylase superfamily K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E MEALZ_3964 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E MEALZ_0419 nth; Endonuclease III (DNA-(apurinic or apyrimidinic site) lyase) K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D MEALZ_0462 Mutator MutT protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D MEALZ_2782 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D MEALZ_1119 conserved protein of unknown function K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D MEALZ_0131 dut; Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (dUTP pyrophosphatase) K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D MEALZ_0760 Methylated-DNA/protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D MEALZ_0376 phr; deoxyribodipyrimidine photo-lyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E MEALZ_2632 Uracil-DNA glycosylase superfamily K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E MEALZ_3311 Putative phage SPO1 DNA polymerase-related protein, uracil-DNA glycosylase family K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E MEALZ_3475 conserved protein of unknown function K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E MEALZ_3474 Uracil-DNA glycosylase superfamily (fragment) K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E MEALZ_3964 mutY; A/G-specific adenine glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31]
E MEALZ_1344 tag; DNA-3-methyladenine glycosylase I (3-methyladenine-DNA glycosylase I) (TAG I) (DNA-3-methyladenine glycosidase I) K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E MEALZ_1612 mutM; Formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18]
E MEALZ_0419 nth; Endonuclease III (DNA-(apurinic or apyrimidinic site) lyase) K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E MEALZ_2631 exoA; Exodeoxyribonuclease K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2]
D RecJ
E MEALZ_1563 recJ; Single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E MEALZ_1634 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
E MEALZ_0386 polA; DNA polymerase I (POL I) K02335 polA; DNA polymerase I [EC:2.7.7.7]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E MEALZ_1480 uvrA; UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A) K03701 uvrA; excinuclease ABC subunit A
E MEALZ_0889 uvrB; UvrABC system protein B (Protein uvrB) (Excinuclease ABC subunit B) K03702 uvrB; excinuclease ABC subunit B
E MEALZ_3473 uvrC; UvrABC system protein C (Protein uvrC) (Excinuclease ABC subunit C) K03703 uvrC; excinuclease ABC subunit C
E MEALZ_2290 uvrD; DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E MEALZ_0386 polA; DNA polymerase I (POL I) K02335 polA; DNA polymerase I [EC:2.7.7.7]
E MEALZ_1634 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F MEALZ_3360 rpoB; DNA-directed RNA polymerase subunit beta (RNAP subunit beta) (Transcriptase subunit beta) (RNA polymerase subunit beta) K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F MEALZ_3359 rpoC; DNA-directed RNA polymerase subunit beta' (RNAP subunit beta') (Transcriptase subunit beta') (RNA polymerase subunit beta') K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F MEALZ_3328 rpoA; RNA polymerase, alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F MEALZ_3550 rpoZ; DNA-directed RNA polymerase subunit omega K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F MEALZ_2217 mfd; Transcription-repair-coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E MEALZ_1132 mutS; DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
E MEALZ_2036 DNA mismatch repair protein MutS domain protein K03555 mutS; DNA mismatch repair protein MutS
D Molecular matchmaker
E MEALZ_1568 mutL; DNA mismatch repair protein MutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E MEALZ_2224 sbcB; Exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E MEALZ_0395 xseA; Exodeoxyribonuclease 7 large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E MEALZ_3089 xseB; Exodeoxyribonuclease 7 small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E MEALZ_3120 dnaE; DNA polymerase III subunit alpha K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E MEALZ_0002 dnaN; DNA polymerase III subunit beta K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E MEALZ_0676 DNA polymerase III chi subunit HolC K02339 holC; DNA polymerase III subunit chi [EC:2.7.7.7]
E MEALZ_3403 holA; DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E MEALZ_2021 DNA polymerase III, delta prime subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E MEALZ_3032 dnaQ; DNA polymerase III subunit epsilon K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E MEALZ_p0082 ycg4D; Ycg4D K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7]
E MEALZ_2406 dnaX; DNA polymerase III subunit tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E MEALZ_1634 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E MEALZ_2290 uvrD; DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E MEALZ_1914 ssb; Single-stranded DNA-binding protein (SSB) (Helix-destabilizing protein) K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E MEALZ_3620 Exodeoxyribonuclease V, beta subunit K03582 recB; exodeoxyribonuclease V beta subunit [EC:3.1.11.5]
E MEALZ_3818 Exodeoxyribonuclease V, gamma subunit K03583 recC; exodeoxyribonuclease V gamma subunit [EC:3.1.11.5]
E MEALZ_3618 recD; Exodeoxyribonuclease V alpha chain K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E MEALZ_2847 recA; Protein RecA (Recombinase A) K03553 recA; recombination protein RecA
E MEALZ_1035 ruvA; Holliday junction DNA helicase ruvA K03550 ruvA; holliday junction DNA helicase RuvA
E MEALZ_1036 ruvB; Holliday junction DNA helicase ruvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E MEALZ_1034 ruvC; Crossover junction endodeoxyribonuclease ruvC (Holliday junction nuclease ruvC) (Holliday juction resolvase ruvC) K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E MEALZ_0141 priA; Primosomal protein N' K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E MEALZ_2224 sbcB; Exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
E MEALZ_2829 SMC domain protein K03546 sbcC; DNA repair protein SbcC/Rad50
E MEALZ_2749 putative exonuclease SbcC K03546 sbcC; DNA repair protein SbcC/Rad50
E MEALZ_2750 putative exonuclease SbcD K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E MEALZ_2847 recA; Protein RecA (Recombinase A) K03553 recA; recombination protein RecA
E MEALZ_3111 radA; DNA repair protein RadA (DNA repair protein Sms) K04485 radA; DNA repair protein RadA/Sms
E MEALZ_0003 recF; DNA replication and repair protein recF K03629 recF; DNA replication and repair protein RecF
E MEALZ_3553 recG; ATP-dependent DNA helicase recG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E MEALZ_1563 recJ; Single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E MEALZ_0570 recO; DNA repair protein recO K03584 recO; DNA repair protein RecO (recombination protein O)
E MEALZ_2404 recR; Recombination protein RecR K06187 recR; recombination protein RecR
E MEALZ_1875 recN; DNA repair protein RecN (Recombination protein N) K03631 recN; DNA repair protein RecN (Recombination protein N)
E MEALZ_1225 rdgC; Recombination-associated protein rdgC K03554 rdgC; recombination associated protein RdgC
E MEALZ_1035 ruvA; Holliday junction DNA helicase ruvA K03550 ruvA; holliday junction DNA helicase RuvA
E MEALZ_1036 ruvB; Holliday junction DNA helicase ruvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E MEALZ_1034 ruvC; Crossover junction endodeoxyribonuclease ruvC (Holliday junction nuclease ruvC) (Holliday juction resolvase ruvC) K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
E MEALZ_1351 CRISPR-associated protein Cas1 K15342 cas1; CRISP-associated protein Cas1
E MEALZ_2157 CRISPR-associated protein Cas1 K15342 cas1; CRISP-associated protein Cas1
E MEALZ_3706 conserved protein of unknown function K15342 cas1; CRISP-associated protein Cas1
D Archaeal homologous recombinant proteins
E MEALZ_2829 SMC domain protein K03546 sbcC; DNA repair protein SbcC/Rad50
E MEALZ_2749 putative exonuclease SbcC K03546 sbcC; DNA repair protein SbcC/Rad50
E MEALZ_2750 putative exonuclease SbcD K03547 sbcD; DNA repair protein SbcD/Mre11
E MEALZ_0278 putative ATPase K06915 herA; DNA double-strand break repair helicase HerA and related ATPase
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F MEALZ_2500 gyrA; DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F MEALZ_0004 gyrB; DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F MEALZ_3423 topA; DNA topoisomerase 1 K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F MEALZ_3046 hupB; DNA-binding protein HU-beta (NS1) (HU-1) K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F MEALZ_1563 recJ; Single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F MEALZ_0570 recO; DNA repair protein recO K03584 recO; DNA repair protein RecO (recombination protein O)
F MEALZ_2404 recR; Recombination protein RecR K06187 recR; recombination protein RecR
F MEALZ_1634 ligA; DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
F MEALZ_2304 fis; DNA-binding protein fis K03557 fis; Fis family transcriptional regulator, factor for inversion stimulation protein
F MEALZ_0901 ihfA; integration host factor, alpha subunit K04764 ihfA; integration host factor subunit alpha
F MEALZ_2492 ihfB; Integration host factor subunit beta (IHF-beta) K05788 ihfB; integration host factor subunit beta
E Supressor
F MEALZ_2224 sbcB; Exodeoxyribonuclease I K01141 sbcB; exodeoxyribonuclease I [EC:3.1.11.1]
F MEALZ_0606 conserved protein of unknown function K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F MEALZ_2784 recQ; ATP-dependent DNA helicase RecQ K03654 recQ; ATP-dependent DNA helicase RecQ [EC:5.6.2.4]
F MEALZ_1480 uvrA; UvrABC system protein A (UvrA protein) (Excinuclease ABC subunit A) K03701 uvrA; excinuclease ABC subunit A
F MEALZ_0889 uvrB; UvrABC system protein B (Protein uvrB) (Excinuclease ABC subunit B) K03702 uvrB; excinuclease ABC subunit B
F MEALZ_1583 Histone family protein nucleoid-structuring protein H-NS K03746 hns; DNA-binding protein H-NS
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D MEALZ_1229 dinB; DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D MEALZ_1071 umuC; component of DNA polymerase V, subunit C K03502 umuC; DNA polymerase V
D MEALZ_1072 umuD; component of DNA polymerase V, subunit D K03503 umuD; DNA polymerase V [EC:3.4.21.-]
D MEALZ_1077 umuD; component of DNA polymerase V, subunit D K03503 umuD; DNA polymerase V [EC:3.4.21.-]
D MEALZ_p0076 umuD; Protein umuD K03503 umuD; DNA polymerase V [EC:3.4.21.-]
C Other SOS response factors
D MEALZ_2847 recA; Protein RecA (Recombinase A) K03553 recA; recombination protein RecA
D MEALZ_1078 lexA; LexA repressor K01356 lexA; repressor LexA [EC:3.4.21.88]
D MEALZ_3562 Transcriptional repressor, LexA family K01356 lexA; repressor LexA [EC:3.4.21.88]
D MEALZ_1875 recN; DNA repair protein RecN (Recombination protein N) K03631 recN; DNA repair protein RecN (Recombination protein N)
D MEALZ_1914 ssb; Single-stranded DNA-binding protein (SSB) (Helix-destabilizing protein) K03111 ssb; single-strand DNA-binding protein
D MEALZ_2846 Regulatory protein RecX K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
D MEALZ_3658 rep; ATP-dependent DNA helicase rep K03656 rep; ATP-dependent DNA helicase Rep [EC:5.6.2.4]
D MEALZ_0208 Helicase IV K03658 helD; DNA helicase IV [EC:5.6.2.4]
D MEALZ_p0079 Helicase IV K03658 helD; DNA helicase IV [EC:5.6.2.4]
D MEALZ_3199 putative ATP-dependent helicase HI_0387 K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3]
D MEALZ_0367 DEAD/H associated domain protein K03724 lhr; ATP-dependent helicase Lhr and Lhr-like helicase [EC:5.6.2.6 5.6.2.4]
C Modulation of nucleotide pools
D MEALZ_0462 Mutator MutT protein K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D MEALZ_2782 NUDIX hydrolase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D MEALZ_1119 conserved protein of unknown function K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D MEALZ_0131 dut; Deoxyuridine 5'-triphosphate nucleotidohydrolase (dUTPase) (dUTP pyrophosphatase) K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D MEALZ_0302 Ribonucleoside-diphosphate reductase, adenosylcobalamin-dependent (modular protein) K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024