+C Lipid biosynthesis protein KO
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Lipid Biosynthesis Proteins - Mycobacterium tuberculosis BT1
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AFatty acid synthase
B Animal type
B Yeast type
B Bacteria type
C HKBT1_2665 fas; fatty-acid synthase K11533 fas; fatty acid synthase, bacteria type [EC:2.3.1.-]
B Component type
C HKBT1_0681 fabD2; malonyl CoA-acyl carrier protein transacylase FabD2 K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]
C HKBT1_2367 fabD; malonyl CoA acyl carrier protein transacylase FabD K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39]
C HKBT1_0259 fabG4; 3-oxoacyl-[acyl-carrier protein] reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
C HKBT1_3760 short chain dehydrogenase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
C HKBT1_1434 fabG2; 3-oxoacyl-[acyl-carrier protein] reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100]
C HKBT1_1707 tesB1; acyl-CoA thioesterase II K10805 tesB; acyl-CoA thioesterase II [EC:3.1.2.-]
C HKBT1_2748 tesB2; acyl-CoA thioesterase II K10805 tesB; acyl-CoA thioesterase II [EC:3.1.2.-]
C HKBT1_0557 fabH; 3-oxoacyl-(acyl carrier protein) synthase III K11608 mtfabH; mycobacterial beta-ketoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.301]
C HKBT1_2369 3-oxoacyl-(acyl carrier protein) synthase II K11609 kasA; meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase I [EC:2.3.1.293]
C HKBT1_2370 kasB; 3-oxoacyl-[acyl-carrier protein] synthase 2 K27070 kasB; meromycolic acid 3-oxoacyl-(acyl carrier protein) synthase II [EC:2.3.1.294]
C HKBT1_1580 fabG1; 3-oxoacyl-[acyl-carrier protein] reductase K11610 mabA; beta-ketoacyl ACP reductase [EC:1.1.1.100]
C HKBT1_0667 hypothetical protein K27071 hadA; meromycolic acid (3R)-3-hydroxyacyl-[acyl carrier protein] dehydratase HadA [EC:4.2.1.-]
C HKBT1_0668 hadB; (3R)-hydroxyacyl-ACP dehydratase subunit HadB K27072 hadB; meromycolic acid (3R)-3-hydroxyacyl-[acyl carrier protein] dehydratase HadB [EC:4.2.1.-]
C HKBT1_0669 hypothetical protein K27073 hadC; meromycolic acid (3R)-3-hydroxyacyl-[acyl carrier protein] dehydratase HadC [EC:4.2.1.-]
C HKBT1_0526 hypothetical protein K27074 hadD; meromycolic acid (3R)-3-hydroxyacyl-[acyl carrier protein] dehydratase HadD [EC:4.2.1.-]
C HKBT1_1581 inhA; NADH-dependent enoyl-[acyl-carrier-protein] reductase K11611 inhA; meromycolic acid enoyl-[acyl-carrier-protein] reductase [EC:1.3.1.118]
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ADesaturase
B First
C HKBT1_0866 desA1; acyl-[acyl-carrier protein] desaturase K03921 FAB2; acyl-[acyl-carrier-protein] desaturase [EC:1.14.19.2 1.14.19.11 1.14.19.26]
C HKBT1_1159 desA2; acyl-[acyl-carrier protein] desaturase K03922 desA2; acyl-[acyl-carrier-protein] desaturase [EC:1.14.19.2]
C HKBT1_3406 putative linoleoyl-CoA desaturase K22769 desA3; NADPH-dependent stearoyl-CoA 9-desaturase [EC:1.14.19.-]
B Omega
B Front-end
B Sphingolipid
B Other
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AElongase
B LCFA
B PUFA
B Unclassified
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APolyketide synthase
B Modular PKS
C HKBT1_3086 mas; multifunctional mycocerosic acid synthase membrane-associated Mas K11628 mas; mycocerosic acid synthase [EC:2.3.1.111]
C HKBT1_3093 pks1; putative polyketide synthase Pks1 K12430 pks1_15; 4-hydroxyphenylalkanoate synthase [EC:2.3.1.261]
C HKBT1_4038 pks2; polyketide synthase Pks2 K12431 pks2; phthioceranic/hydroxyphthioceranic acid synthase [EC:2.3.1.287]
C HKBT1_2163 pks12; polyketide synthase Pks12 K12436 pks12; mycoketide-CoA synthase [EC:2.3.1.295]
C HKBT1_4012 pks13; polyketide synthase Pks13 K12437 pks13; polyketide synthase 13
C HKBT1_3077 ppsA; phenolpthiocerol synthesis type-I polyketide synthase PpsA K12440 ppsA; phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase A [EC:2.3.1.292]
C HKBT1_3078 ppsB; phenolpthiocerol synthesis type-I polyketide synthase PpsB K12441 ppsB; phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase B [EC:2.3.1.292]
C HKBT1_3079 ppsC; phenolpthiocerol synthesis type-I polyketide synthase PpsC K12442 ppsC; phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase C [EC:2.3.1.292]
C HKBT1_3080 ppsD; phenolpthiocerol synthesis type-I polyketide synthase PpsD K12443 ppsD; phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase D [EC:2.3.1.292]
C HKBT1_3081 ppsE; phenolpthiocerol synthesis type-I polyketide synthase PpsD K12444 ppsE; phthiocerol/phenolphthiocerol synthesis type-I polyketide synthase E [EC:2.3.1.292]
B Component type
C HKBT1_2512 mbtC; polyketide synthetase MbtC K04790 mbtC; mycobactin polyketide synthetase MbtC
C HKBT1_2511 mbtD; putative polyketide synthase MbtD K04791 mbtD; mycobactin polyketide synthetase MbtD
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AAcyl-CoA synthetase
B Short/medium chain acyl-CoA synthetase
C HKBT1_3870 acs; acetyl-CoA synthetase K01895 ACSS1_2; acetyl-CoA synthetase [EC:6.2.1.1]
B Long/very long chain acyl-CoA synthetase
C HKBT1_2306 fadD15; long-chain-fatty-acid--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3]
C HKBT1_1773 acyl-CoA synthetase K03822 K03822; putative long chain acyl-CoA synthase [EC:6.2.1.-]
C HKBT1_0105 fadD10; fatty-acid-CoA ligase K12422 fadD10; long chain fatty acid CoA ligase FadD10 [EC:6.2.1.-]
C HKBT1_4039 fadD23; acyl-CoA synthetase K12425 fadD23; long-chain fatty acid adenylase/transferase FadD23 [EC:6.2.1.57]
C HKBT1_3076 fadD26; acyl-CoA synthetase K12426 fadD26; long-chain fatty acid adenylase/transferase FadD26 [EC:6.2.1.59]
C HKBT1_3087 fadD28; acyl-CoA synthetase K12427 fadD28; long-chain fatty acid adenylyltransferase FadD28 [EC:6.2.1.49]
C HKBT1_3096 fadD29; acyl-CoA synthetase K21059 fadD29; 4-hydroxyphenylalkanoate adenylyltransferase [EC:6.2.1.51]
C HKBT1_1269 fadD36; acyl-CoA synthetase K12429 fadD36; fatty acid CoA ligase FadD36
B Unknown
C HKBT1_2732 fadD9; fatty-acid-CoA ligase FadD9 K12421 fadD9; fatty acid CoA ligase FadD9
C HKBT1_1261 fadD21; acyl-CoA synthetase K12423 fadD21; fatty acid CoA ligase FadD21
C HKBT1_3094 fadD22; acyl-CoA synthetase K12424 fadD22; 4-hydroxybenzoate adenylyltransferase [EC:6.2.1.50]
C HKBT1_4013 fadD32; acyl-CoA synthetase K12428 fadD32; fatty acid CoA ligase FadD32
C HKBT1_1065 pks16; polyketide synthase Pks16 K00666 K00666; fatty-acyl-CoA synthase [EC:6.2.1.-]
C HKBT1_0575 fadD8; fatty-acid-CoA ligase FadD8 K00666 K00666; fatty-acyl-CoA synthase [EC:6.2.1.-]
C HKBT1_0181 fadD5; fatty-acid-CoA ligase K00666 K00666; fatty-acyl-CoA synthase [EC:6.2.1.-]
C HKBT1_1845 fadD1; acyl-CoA synthetase K00666 K00666; fatty-acyl-CoA synthase [EC:6.2.1.-]
C HKBT1_3708 fadD17; acyl-CoA synthetase K00666 K00666; fatty-acyl-CoA synthase [EC:6.2.1.-]
C HKBT1_2645 fadD35; AMP-binding domain protein K00666 K00666; fatty-acyl-CoA synthase [EC:6.2.1.-]
C HKBT1_2019 fadD31; acyl-CoA synthetase K00666 K00666; fatty-acyl-CoA synthase [EC:6.2.1.-]
C HKBT1_1282 fadD6; acyl-CoA synthetase K00666 K00666; fatty-acyl-CoA synthase [EC:6.2.1.-]
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APhospholipid acyltransferase
B GPAT
C HKBT1_2619 plsB2; glycerol-3-phosphate acyltransferase K00631 plsB; glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15]
C HKBT1_1652 glycerol-3-phosphate acyltransferase K00631 plsB; glycerol-3-phosphate O-acyltransferase [EC:2.3.1.15]
B LPAAT/LPLAT
C HKBT1_2301 1-acylglycerol-3-phosphate O-acyltransferase K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51]
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AOthers
B Multifunctional type
C HKBT1_1257 pks3; polyketide beta-ketoacyl synthase Pks3 K12432 pks3_4; mycolipanoate synthase [EC:2.3.1.252]
C HKBT1_1628 pks5; putative polyketide synthase pks5 K12433 pks5; polyketide synthase 5
C HKBT1_1751 pks7; putative polyketide synthase Pks7 K12434 pks7; polyketide synthase 7
C HKBT1_1752 pks8; putative polyketide synthase Pks8 K12435 pks8; polyketide synthase 8
C HKBT1_1753 pks17; putative polyketide synthase Pks17 K12439 pks17; polyketide synthase 17
B Component type
C HKBT1_3099 hypothetical protein K12445 K12445; trans enoyl reductase [EC:1.3.1.-]
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#[ COMPOUND | BRITE | KEGG2 | KEGG ]
#Last updated: November 27, 2023
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Desaturase/elongase family classification based on Hashimoto et al. (2008)