+F Repair protein KO
#
DNA Repair and Recombination Proteins - Saccharomyces cerevisiae (budding yeast)
%
!
AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D YDL200C MGT1; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D YOR386W PHR1; deoxyribodipyrimidine photo-lyase PHR1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E YML021C UNG1; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E YML060W OGG1; 8-oxoguanine glycosylase OGG1 K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E YAL015C NTG1; bifunctional N-glycosylase/AP lyase NTG1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
E YOL043C NTG2; bifunctional N-glycosylase/AP lyase NTG2 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E YKL114C APN1; DNA-(apurinic or apyrimidinic site) lyase APN1 K10771 APEX1; AP endonuclease 1 [EC:3.1.11.2]
E YBL019W APN2; DNA-(apurinic or apyrimidinic site) lyase APN2 K10772 APEX2; AP endonuclease 2 [EC:3.1.11.2]
D Long Patch-BER factors
E DNA polymerase delta complex
F YDL102W POL3; DNA-directed DNA polymerase delta POL3 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
F YJR006W POL31; DNA-directed DNA polymerase delta subunit POL31 K02328 POLD2; DNA polymerase delta subunit 2
F YJR043C POL32; DNA polymerase delta subunit POL32 K03504 POLD3; DNA polymerase delta subunit 3
E DNA polymerase epsilon complex
F YNL262W POL2; DNA polymerase epsilon catalytic subunit K02324 POLE; DNA polymerase epsilon subunit 1 [EC:2.7.7.7]
F YPR175W DPB2; DNA polymerase epsilon noncatalytic subunit K02325 POLE2; DNA polymerase epsilon subunit 2 [EC:2.7.7.7]
F YDR121W DPB4; DNA polymerase epsilon noncatalytic subunit K02326 POLE3; DNA polymerase epsilon subunit 3 [EC:2.7.7.7]
F YBR278W DPB3; DNA polymerase epsilon noncatalytic subunit K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
F YJL065C DLS1; Dls1p K03506 POLE4; DNA polymerase epsilon subunit 4 [EC:2.7.7.7]
E YBR088C POL30; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E YKL113C RAD27; multifunctional nuclease RAD27 K04799 FEN1; flap endonuclease-1 [EC:3.1.-.-]
E YDL164C CDC9; DNA ligase (ATP) CDC9 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
D Short Patch-BER factors
D Other BER factors
E YBR223C TDP1; tyrosyl-DNA phosphodiesterase 1 K10862 TDP1; tyrosyl-DNA phosphodiesterase 1 [EC:3.1.4.-]
E YOR258W HNT3; DNA 5'-adenosine monophosphate hydrolase K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
E YMR156C TPP1; polynucleotide 3'-phosphatase K08075 E3.1.3.32; polynucleotide 3'-phosphatase [EC:3.1.3.32]
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
F YER162C RAD4; Rad4p K10838 XPC; xeroderma pigmentosum group C-complementing protein
F YEL037C RAD23; Rad23p K10839 RAD23; UV excision repair protein RAD23
E Cul4-DDB2 complex
F YOL133W HRT1; SCF ubiquitin ligase complex subunit HRT1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
E NER4 complex
F YJR052W RAD7; UV-damaged DNA-binding protein RAD7 K15082 RAD7; DNA repair protein RAD7
F YBR114W RAD16; DNA repair protein RAD16 K15083 RAD16; DNA repair protein RAD16
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
F YDL140C RPO21; DNA-directed RNA polymerase II core subunit RPO21 K03006 RPB1; DNA-directed RNA polymerase II subunit RPB1 [EC:2.7.7.6]
F YOR151C RPB2; DNA-directed RNA polymerase II core subunit RPB2 K03010 RPB2; DNA-directed RNA polymerase II subunit RPB2 [EC:2.7.7.6]
F YIL021W RPB3; DNA-directed RNA polymerase II core subunit RPB3 K03011 RPB3; DNA-directed RNA polymerase II subunit RPB3
F YJL140W RPB4; DNA-directed RNA polymerase II subunit RPB4 K03012 RPB4; DNA-directed RNA polymerase II subunit RPB4
F YBR154C RPB5; DNA-directed RNA polymerase core subunit RPB5 K03013 RPABC1; DNA-directed RNA polymerases I, II, and III subunit RPABC1
F YPR187W RPO26; DNA-directed RNA polymerase core subunit RPO26 K03014 RPABC2; DNA-directed RNA polymerases I, II, and III subunit RPABC2
F YDR404C RPB7; DNA-directed RNA polymerase II subunit RPB7 K03015 RPB7; DNA-directed RNA polymerase II subunit RPB7
F YOR224C RPB8; DNA-directed RNA polymerase core subunit RPB8 K03016 RPABC3; DNA-directed RNA polymerases I, II, and III subunit RPABC3
F YGL070C RPB9; DNA-directed RNA polymerase II core subunit RPB9 K03017 RPB9; DNA-directed RNA polymerase II subunit RPB9
F YOR210W RPB10; DNA-directed RNA polymerase core subunit RPB10 K03007 RPABC5; DNA-directed RNA polymerases I, II, and III subunit RPABC5
F YOL005C RPB11; DNA-directed RNA polymerase II core subunit RPB11 K03008 RPB11; DNA-directed RNA polymerase II subunit RPB11
F YHR143W-A RPC10; DNA-directed RNA polymerase core subunit RPC10 K03009 RPABC4; DNA-directed RNA polymerases I, II, and III subunit RPABC4
E Cul4-CSA complex
F YOL133W HRT1; SCF ubiquitin ligase complex subunit HRT1 K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
F YDR030C RAD28; Rad28p K10570 ERCC8; DNA excision repair protein ERCC-8
E Other TCR factor
F YJR035W RAD26; DNA-dependent ATPase RAD26 K10841 ERCC6; DNA excision repair protein ERCC-6
F YKL160W ELF1; Elf1p K25829 ELOF1; transcription elongation factor 1
D TFIIH complex
E YIL143C SSL2; TFIIH/NER complex ATPase/helicase subunit SSL2 K10843 ERCC3; DNA excision repair protein ERCC-3 [EC:5.6.2.4]
E YER171W RAD3; TFIIH/NER complex ATP-dependent 5'-3' DNA helicase subunit RAD3 K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
E YDR311W TFB1; TFIIH/NER complex subunit TFB1 K03141 TFIIH1; transcription initiation factor TFIIH subunit 1
E YLR005W SSL1; TFIIH/NER complex subunit SSL1 K03142 TFIIH2; transcription initiation factor TFIIH subunit 2
E YPR056W TFB4; TFIIH/NER complex subunit TFB4 K03143 TFIIH3; transcription initiation factor TFIIH subunit 3
E YPL122C TFB2; TFIIH/NER complex subunit TFB2 K03144 TFIIH4; transcription initiation factor TFIIH subunit 4
E YDR079C-A TFB5; TFIIH complex subunit TFB5 K10845 TTDA; TFIIH basal transcription factor complex TTD-A subunit
E YDL108W KIN28; TFIIH complex serine/threonine-protein kinase subunit KIN28 K02202 CDK7; cyclin-dependent kinase 7 [EC:2.7.11.22 2.7.11.23]
E YPR025C CCL1; TFIIH complex kinase subunit CCL1 K06634 CCNH; cyclin H
E YDR460W TFB3; TFIIH/NER complex subunit TFB3 K10842 MNAT1; CDK-activating kinase assembly factor MAT1
D RPA (replication factor A)
E YAR007C RFA1; replication factor A subunit protein RFA1 K07466 RFA1; replication factor A1
E YNL312W RFA2; Rfa2p K10739 RFA2; replication factor A2
D Other NER factors
E YMR201C RAD14; DNA repair protein RAD14 K10847 XPA; DNA-repair protein complementing XP-A cells
E YML095C RAD10; DNA repair protein RAD10 K10849 ERCC1; DNA excision repair protein ERCC-1
E YPL022W RAD1; ssDNA endodeoxyribonuclease RAD1 K10848 ERCC4; DNA excision repair protein ERCC-4 [EC:3.1.-.-]
E YGR258C RAD2; ssDNA endodeoxyribonuclease RAD2 K10846 ERCC5; DNA excision repair protein ERCC-5
E YDL164C CDC9; DNA ligase (ATP) CDC9 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E YIL128W MET18; Met18p K15075 MET18; DNA repair/transcription protein MET18/MMS19
E YGR003W CUL3; cullin CUL3 K03869 CUL3; cullin 3
E YPL046C ELC1; elongin C K03872 ELOC; elongin-C
E YNL230C ELA1; elongin A K15077 ELA1; elongin-A
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E YOL090W MSH2; mismatch repair ATPase MSH2 K08735 MSH2; DNA mismatch repair protein MSH2
E YCR092C MSH3; mismatch repair protein MSH3 K08736 MSH3; DNA mismatch repair protein MSH3
E YDR097C MSH6; mismatch repair ATPase MSH6 K08737 MSH6; DNA mismatch repair protein MSH6
D MutL homologs
E YLR035C MLH2; mismatch repair protein MLH2 K10864 PMS1; DNA mismatch repair protein PMS1
E YMR167W MLH1; mismatch repair ATPase MLH1 K08734 MLH1; DNA mismatch repair protein MLH1
E YNL082W PMS1; ATP-binding mismatch repair protein K10858 PMS2; DNA mismatch repair protein PMS2
E YPL164C MLH3; mismatch repair protein MLH3 K08739 MLH3; DNA mismatch repair protein MLH3
D DNA polymerase delta complex
E YDL102W POL3; DNA-directed DNA polymerase delta POL3 K02327 POLD1; DNA polymerase delta subunit 1 [EC:2.7.7.7]
E YJR006W POL31; DNA-directed DNA polymerase delta subunit POL31 K02328 POLD2; DNA polymerase delta subunit 2
E YJR043C POL32; DNA polymerase delta subunit POL32 K03504 POLD3; DNA polymerase delta subunit 3
D RPA (replication factor A)
E YAR007C RFA1; replication factor A subunit protein RFA1 K07466 RFA1; replication factor A1
E YNL312W RFA2; Rfa2p K10739 RFA2; replication factor A2
D RFC (replication factor C)
E YOR217W RFC1; replication factor C subunit 1 K10754 RFC1; replication factor C subunit 1
E YJR068W RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
E YOL094C RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
E YNL290W RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
E YBR087W RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
D Other MMR factors
E YBR088C POL30; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
E YOR033C EXO1; Rad2 family nuclease EXO1 K10746 EXO1; exonuclease 1 [EC:3.1.-.-]
E YDL164C CDC9; DNA ligase (ATP) CDC9 K10747 LIG1; DNA ligase 1 [EC:6.5.1.1 6.5.1.6 6.5.1.7]
E YDL156W CMR1; Cmr1p K24755 WDR76; WD repeat-containing protein 76
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
E YMR224C MRE11; MRX complex nuclease subunit K10865 MRE11; double-strand break repair protein MRE11
E YNL250W RAD50; MRX complex DNA-binding subunit K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E YDR369C XRS2; Xrs2p K10868 XRS2; DNA repair protein XRS2
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
E YMR224C MRE11; MRX complex nuclease subunit K10865 MRE11; double-strand break repair protein MRE11
E YNL250W RAD50; MRX complex DNA-binding subunit K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
D BRCA complex
E YER095W RAD51; recombinase RAD51 K04482 RAD51; DNA repair protein RAD51
D RecA family proteins
E YER095W RAD51; recombinase RAD51 K04482 RAD51; DNA repair protein RAD51
E YDR076W RAD55; putative DNA-dependent ATPase RAD55 K10957 RAD55; DNA repair protein RAD55
E YDR004W RAD57; putative DNA-dependent ATPase RAD57 K10958 RAD57; DNA repair protein RAD57
D Rad52 family proteins
E YML032C RAD52; recombinase RAD52 K10873 RAD52; DNA repair and recombination protein RAD52
E YDL059C RAD59; Rad59p K10959 RAD59; DNA repair protein RAD59
D Rad54 family proteins
E YGL163C RAD54; DNA-dependent ATPase RAD54 K10875 RAD54L; DNA repair and recombination protein RAD54 and RAD54-like protein [EC:5.6.2.-]
E YBR073W RDH54; DNA-dependent ATPase RDH54 K10877 RAD54B; DNA repair and recombination protein RAD54B [EC:5.6.2.-]
D RecQ family DNA helicases
E YMR190C SGS1; ATP-dependent DNA helicase SGS1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
D Bloom's syndrome complex (BTR)
E YMR190C SGS1; ATP-dependent DNA helicase SGS1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E YLR234W TOP3; DNA topoisomerase 3 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E YPL024W RMI1; Rmi1p K15364 NCE4; RecQ-mediated genome instability protein 1
D RPA (replication factor A)
E YAR007C RFA1; replication factor A subunit protein RFA1 K07466 RFA1; replication factor A1
E YNL312W RFA2; Rfa2p K10739 RFA2; replication factor A2
D Protein phosphatase 4
E YDR075W PPH3; phosphoprotein phosphatase PP4 catalytic subunit PPH3 K15423 PPP4C; serine/threonine-protein phosphatase 4 catalytic subunit [EC:3.1.3.16]
E YNL201C PSY2; Psy2p K17491 SMEK; protein phosphatase 4 regulatory subunit 3
D AP-5 complex
D SMC5-SMC6 complex
E YOL034W SMC5; DNA repair ATPase SMC5 K22803 SMC5; structural maintenance of chromosomes protein 5
E YLR383W SMC6; DNA repair protein SMC6 K22804 SMC6; structural maintenance of chromosomes protein 6
E YLR007W NSE1; Smc5-Smc6 complex subunit NSE1 K22817 NSMCE1; non-structural maintenance of chromosomes element 1 [EC:2.3.2.27]
E YEL019C MMS21; SUMO ligase MMS21 K22756 NSMCE2; E3 SUMO-protein ligase NSE2 [EC:2.3.2.-]
E YDR288W NSE3; Smc5-Smc6 complex subunit NSE3 K22823 NSMCE3; non-structural maintenance of chromosomes element 3
E YDL105W NSE4; Smc5-Smc6 complex subunit NSE4 K22825 NSMCE4; non-structural maintenance of chromosomes element 4
D Other HR factors
E YBR098W MMS4; Mms4p K10882 EME1; crossover junction endonuclease EME1 [EC:3.1.22.-]
E YDR386W MUS81; Mus81p K08991 MUS81; crossover junction endonuclease MUS81 [EC:3.1.22.-]
E YDR363W-A SEM1; proteasome regulatory particle lid subunit SEM1 K10881 SHFM1; 26 proteasome complex subunit DSS1
E YHR079C-A SAE3; Sae3p K10991 SWI5; DNA repair protein Swi5/Sae3
E YPL121C MEI5; Mei5p K10992 SFR1; Swi5-dependent recombination DNA repair protein 1
E YBR228W SLX1; endonuclease K15078 SLX1; structure-specific endonuclease subunit SLX1 [EC:3.6.1.-]
E YLR135W SLX4; Slx4p K15079 SLX4; structure-specific endonuclease subunit SLX4
E YER041W YEN1; crossover junction endodeoxyribonuclease K15338 GEN1; holliday junction resolvase GEN1/YEN1 [EC:3.1.-.-]
E YPR023C EAF3; Eaf3p K11339 MORF4L1; mortality factor 4-like protein 1
E YER047C SAP1; putative AAA family ATPase SAP1 K22766 FIGNL1; fidgetin-like protein 1 [EC:5.6.2.-]
E YHR134W WSS1; metalloendopeptidase WSS1 K22685 WSS1; DNA-dependent metalloprotease WSS1 [EC:3.4.24.-]
E YIR002C MPH1; 3'-5' DNA helicase K14635 MPH1; ATP-dependent DNA helicase MPH1 [EC:5.6.2.4]
E YAL027W SAW1; DNA-binding protein SAW1 K15080 SAW1; single-strand annealing weakened protein 1
E YJL047C RTT101; cullin RTT101 K26124 RTT101; cullin 8
E YLR320W MMS22; Mms22p K26122 MMS22; E3 ubiquitin-protein ligase substrate receptor MMS22
E YPR164W MMS1; Mms1p K26123 MMS1; E3 ubiquitin-protein ligase linker protein MMS1
C NHEJ (non-homologous end-joining)
D DNA-PK complex
E YMR284W YKU70; ATP-dependent DNA helicase YKU70 K10884 XRCC6; ATP-dependent DNA helicase 2 subunit 1
E YMR106C YKU80; ATP-dependent DNA helicase YKU80 K10885 XRCC5; ATP-dependent DNA helicase 2 subunit 2
D MRX complex
E YMR224C MRE11; MRX complex nuclease subunit K10865 MRE11; double-strand break repair protein MRE11
E YNL250W RAD50; MRX complex DNA-binding subunit K10866 RAD50; DNA repair protein RAD50 [EC:3.6.-.-]
E YDR369C XRS2; Xrs2p K10868 XRS2; DNA repair protein XRS2
D DNA Ligase 4 complex
E YOR005C DNL4; DNA ligase (ATP) DNL4 K10777 LIG4; DNA ligase 4 [EC:6.5.1.1]
E YGL090W LIF1; Lif1p K10982 LIF1; ligase-interacting factor 1
E YLR265C NEJ1; Nej1p K10983 NEJ1; non-homologous end-joining protein 1
D X-family DNA polymerases
E YCR014C POL4; DNA-directed DNA polymerase IV K10981 POL4; DNA polymerase IV [EC:2.7.7.7]
D Other NHEJ factors
E YOR258W HNT3; DNA 5'-adenosine monophosphate hydrolase K10863 APTX; aprataxin [EC:3.6.1.70 3.6.1.71 3.6.1.72]
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
E YOL086W-A MHF1; Mhf1p K11511 APITD1; centromere protein S
D Bloom's syndrome complex (BTR)
E YMR190C SGS1; ATP-dependent DNA helicase SGS1 K10901 BLM; bloom syndrome protein [EC:5.6.2.4]
E YLR234W TOP3; DNA topoisomerase 3 K03165 TOP3; DNA topoisomerase III [EC:5.6.2.1]
E YPL024W RMI1; Rmi1p K15364 NCE4; RecQ-mediated genome instability protein 1
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
E YER095W RAD51; recombinase RAD51 K04482 RAD51; DNA repair protein RAD51
E YGR099W TEL2; Tel2p K11137 TELO2; telomere length regulation protein
E YOL087C DUF1; Duf1p K15361 WDR48; WD repeat-containing protein 48
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
E YNL187W SWT21; Swt21p K23314 WRAP53; telomerase Cajal body protein 1
E YDL156W CMR1; Cmr1p K24755 WDR76; WD repeat-containing protein 76
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D YDR419W RAD30; DNA-directed DNA polymerase eta K03509 POLH; DNA polymerase eta [EC:2.7.7.7]
D YOR346W REV1; deoxycytidyl transferase K03515 REV1; DNA repair protein REV1 [EC:2.7.7.-]
C B-family DNA polymerases
D YPL167C REV3; DNA-directed DNA polymerase K02350 REV3L; DNA polymerase zeta [EC:2.7.7.7]
D YIL139C REV7; Rev7p K03508 POLZ2; DNA polymerase zeta [EC:2.7.7.7]
C A-family DNA polymerase
C Rad6 epistasis group
D YGL058W RAD6; E2 ubiquitin-conjugating protein RAD6 K10573 UBE2A; ubiquitin-conjugating enzyme E2 A [EC:2.3.2.23]
D YCR066W RAD18; E3 ubiquitin-protein ligase RAD18 K10627 RAD18; E3 ubiquitin-protein ligase RAD18 [EC:2.3.2.27]
D YLR032W RAD5; DNA helicase RAD5 K15505 RAD5; DNA repair protein RAD5 [EC:5.6.2.-]
D YGL087C MMS2; E2 ubiquitin-conjugating protein MMS2 K10704 UBE2V; ubiquitin-conjugating enzyme E2 variant
D YDR092W UBC13; E2 ubiquitin-conjugating protein UBC13 K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Other TLS factors
D YBR088C POL30; proliferating cell nuclear antigen K04802 PCNA; proliferating cell nuclear antigen
B Check point factors
C Rad9-Hus1-Rad1 complex
D YOR368W RAD17; Rad17p K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
C HRAD17(Rad24)-RFC complex
D YER173W RAD24; Rad24p K06662 HRAD17; cell cycle checkpoint protein
D YJR068W RFC2; replication factor C subunit 2 K10755 RFC2_4; replication factor C subunit 2/4
D YOL094C RFC4; replication factor C subunit 4 K10755 RFC2_4; replication factor C subunit 2/4
D YNL290W RFC3; replication factor C subunit 3 K10756 RFC3_5; replication factor C subunit 3/5
D YBR087W RFC5; replication factor C subunit 5 K10756 RFC3_5; replication factor C subunit 3/5
C Rad17-Mec3-Ddc1 complex
D YOR368W RAD17; Rad17p K02830 HRAD1; cell cycle checkpoint protein [EC:3.1.11.2]
D YLR288C MEC3; Mec3p K02544 MEC3; G2-specific checkpoint protein
D YPL194W DDC1; Ddc1p K06663 DDC1; DNA damage checkpoint protein
C FPC (fork protection complex)
D YNL273W TOF1; Tof1p K10997 TIMELESS; replication fork protection complex subunit TIMELESS/Tof1/Swi1
D YMR048W CSM3; Csm3p K10998 TIPIN; replication fork protection complex subunit TIPIN/Csm3/Swi3
D YCL061C MRC1; chromatin-modulating protein MRC1 K11272 MRC1; mediator of replication checkpoint protein 1
C Triple T complex
D YGR099W TEL2; Tel2p K11137 TELO2; telomere length regulation protein
D YKL033W TTI1; Tti1p K20403 TTI1; TELO2-interacting protein 1
C BAG6-UBL4A-GET4 complex
D YOL111C MDY2; Mdy2p K23388 UBL4; ubiquitin-like protein 4
D YOR164C GET4; Get4p K23387 GET4; golgi to ER traffic protein 4
C Other check point factors
D YBL088C TEL1; DNA-binding protein kinase TEL1 K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
D YBR274W CHK1; serine/threonine protein kinase CHK1 K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
D YDL101C DUN1; serine/threonine protein kinase DUN1 K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
D YMR036C MIH1; putative tyrosine protein phosphatase MIH1 K02555 MIH1; M-phase inducer tyrosine phosphatase [EC:3.1.3.48]
D YER177W BMH1; 14-3-3 family protein BMH1 K06630 YWHAE; 14-3-3 protein epsilon
D YDR099W BMH2; 14-3-3 family protein BMH2 K06630 YWHAE; 14-3-3 protein epsilon
D YPL153C RAD53; serine/threonine/tyrosine protein kinase RAD53 K02831 RAD53; ser/thr/tyr protein kinase RAD53 [EC:2.7.11.-]
D YDR217C RAD9; chromatin-binding protein RAD9 K06661 RAD9; DNA repair protein RAD9
D YBR136W MEC1; protein kinase MEC1 K02543 MEC1; cell cycle checkpoint protein MEC1
D YBR158W AMN1; Amn1p K15081 AMN1; antagonist of mitotic exit network protein 1
D YJL187C SWE1; tyrosine protein kinase SWE1 K03114 SWE1; mitosis inhibitor protein kinase SWE1 [EC:2.7.11.1]
D YOR372C NDD1; Ndd1p K24663 NDD1; nuclear division defective protein 1
D YNL068C FKH2; forkhead family transcription factor FKH2 K24664 FKH; forkhead protein FKH
D YIL131C FKH1; forkhead family transcription factor FKH1 K24664 FKH; forkhead protein FKH
D YPR173C VPS4; AAA family ATPase VPS4 K12196 VPS4; vacuolar protein-sorting-associated protein 4
B Other factors with a suspected DNA repair function
C DNA polymerases
D YEL055C POL5; DNA-directed DNA polymerase K02331 POL5; DNA polymerase phi [EC:2.7.7.7]
C Nucleases
D YMR137C PSO2; DNA cross-link repair protein PSO2 K15340 DCLRE1A; DNA cross-link repair 1A protein
D YBR163W EXO5; Exo5p K17815 EXO5; exonuclease V [EC:3.1.-.-]
C Helicases
C PSO4 complex
D YLL036C PRP19; E3 ubiquitin-protein ligase PRP19 K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
D YMR213W CEF1; Cef1p K12860 CDC5L; pre-mRNA-splicing factor CDC5/CEF1
D YPL151C PRP46; mRNA splicing protein PRP46 K12862 PLRG1; pleiotropic regulator 1
C Modulation of nucleotide pools
D YBR252W DUT1; bifunctional dITP/dUTP diphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D YIL066C RNR3; ribonucleotide-diphosphate reductase subunit RNR3 K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D YER070W RNR1; ribonucleotide-diphosphate reductase subunit RNR1 K10807 RRM1; ribonucleoside-diphosphate reductase subunit M1 [EC:1.17.4.1]
D YJL026W RNR2; ribonucleotide-diphosphate reductase subunit RNR2 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
D YGR180C RNR4; ribonucleotide-diphosphate reductase subunit RNR4 K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
#
AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D YDL200C MGT1; methylated-DNA--protein-cysteine methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
D YOR386W PHR1; deoxyribodipyrimidine photo-lyase PHR1 K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3]
C BER (base exicision repair)
D DNA glycosylases
E YML021C UNG1; uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27]
E YER142C MAG1; DNA-3-methyladenine glycosylase II K01247 alkA; DNA-3-methyladenine glycosylase II [EC:3.2.2.21]
E YAL015C NTG1; bifunctional N-glycosylase/AP lyase NTG1 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
E YOL043C NTG2; bifunctional N-glycosylase/AP lyase NTG2 K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D RecJ
D DNA ligase
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E YJL092W SRS2; DNA helicase SRS2 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
E TRCF (transcription-repair coupling factor)
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D Molecular matchmaker
D Strand discrimination factor
D DNA exonucleases
D DNA polymerase III holoenzyme
D DNA ligase
D Other MMR factors
E YJL092W SRS2; DNA helicase SRS2 K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
D RecFOR pathway proteins
D AddAB pathway proteins
D Other HR factor
D Archaeal homologous recombinant proteins
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
E Supressor
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
E Facilitator
E Supressor
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C Other SOS response factors
B Other factors with a suspected DNA repair function
C DNA polymerase
C DNA helicases
C Modulation of nucleotide pools
D YBR252W DUT1; bifunctional dITP/dUTP diphosphatase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
C Others
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024