+D GENES KO #

  KEGG Orthology (KO) - Streptococcus pyogenes MGAS10394 (serotype M6)

% ! A09100 Metabolism B B 09101 Carbohydrate metabolism C 00010 Glycolysis / Gluconeogenesis [PATH:spa00010] D M6_Spy1278 Glucokinase K25026 glk; glucokinase [EC:2.7.1.2] D M6_Spy0219 Glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9] D M6_Spy0976 Non-allosteric 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D M6_Spy1616 Fructose-bisphosphate aldolase K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13] D M6_Spy0530 Triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1] D M6_Spy0265 Glyceraldehyde 3-phosphate dehydrogenase K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] D M6_Spy1610 Phosphoglycerate kinase K00927 PGK; phosphoglycerate kinase [EC:2.7.2.3] D M6_Spy1190 Phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] D M6_Spy0577 Enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] D M6_Spy0975 Pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40] D M6_Spy0776 Pyruvate dehydrogenase E1 component alpha subunit K00161 PDHA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1] D M6_Spy0777 Pyruvate dehydrogenase E1 component beta subunit K00162 PDHB; pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1] D M6_Spy0778 Dihydrolipoamide acetyltransferase K00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12] D M6_Spy0779 Dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D M6_Spy0869 L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27] D M6_Spy0088 Alcohol dehydrogenase K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1] D M6_Spy0090 Alcohol dehydrogenase K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1] D M6_Spy0832 Zn-dependent alcohol dehydrogenases and related dehydrogenases K00001 E1.1.1.1; alcohol dehydrogenase [EC:1.1.1.1] D M6_Spy0927 phosphoglucomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D M6_Spy1093 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase K00131 gapN; glyceraldehyde-3-phosphate dehydrogenase (NADP+) [EC:1.2.1.9] D M6_Spy0500 6-phospho-beta-glucosidase K01223 E3.2.1.86B; 6-phospho-beta-glucosidase [EC:3.2.1.86] D M6_Spy1054 Beta-glucosidase K01223 E3.2.1.86B; 6-phospho-beta-glucosidase [EC:3.2.1.86] C 00020 Citrate cycle (TCA cycle) [PATH:spa00020] D M6_Spy0779 Dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D M6_Spy0776 Pyruvate dehydrogenase E1 component alpha subunit K00161 PDHA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1] D M6_Spy0777 Pyruvate dehydrogenase E1 component beta subunit K00162 PDHB; pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1] D M6_Spy0778 Dihydrolipoamide acetyltransferase K00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12] C 00030 Pentose phosphate pathway [PATH:spa00030] D M6_Spy0219 Glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9] D M6_Spy0256 Ribulose-phosphate 3-epimerase K01783 rpe; ribulose-phosphate 3-epimerase [EC:5.1.3.1] D M6_Spy1423 Transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1] D M6_Spy1669 Transaldolase K00616 TALDO1; transaldolase [EC:2.2.1.2] D M6_Spy1424 Transaldolase K00616 TALDO1; transaldolase [EC:2.2.1.2] D M6_Spy0712 Ribose 5-phosphate isomerase K01807 rpiA; ribose 5-phosphate isomerase A [EC:5.3.1.6] D M6_Spy1597 Deoxyribose-phosphate aldolase K01619 deoC; deoxyribose-phosphate aldolase [EC:4.1.2.4] D M6_Spy0713 Phosphopentomutase K01839 deoB; phosphopentomutase [EC:5.4.2.7] D M6_Spy0927 phosphoglucomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D M6_Spy0018 Ribose-phosphate pyrophosphokinase K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1] D M6_Spy0843 Ribose-phosphate pyrophosphokinase K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1] D M6_Spy0548 4-Hydroxy-2-oxoglutarate aldolase K01625 eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42] D M6_Spy1093 NADP-dependent glyceraldehyde-3-phosphate dehydrogenase K00131 gapN; glyceraldehyde-3-phosphate dehydrogenase (NADP+) [EC:1.2.1.9] D M6_Spy0547 2-dehydro-3-deoxygluconokinase K00874 kdgK; 2-dehydro-3-deoxygluconokinase [EC:2.7.1.45] D M6_Spy1616 Fructose-bisphosphate aldolase K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13] D M6_Spy0976 Non-allosteric 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] C 00040 Pentose and glucuronate interconversions [PATH:spa00040] D M6_Spy1870 UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D M6_Spy0483 UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D M6_Spy0224 UTP--glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D M6_Spy1871 UTP--glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D M6_Spy0197 3-keto-L-gulonate-6-phosphate decarboxylase K03078 ulaD; 3-dehydro-L-gulonate-6-phosphate decarboxylase [EC:4.1.1.85] D M6_Spy0198 L-xylulose 5-phosphate 3-epimerase K03079 ulaE; L-ribulose-5-phosphate 3-epimerase [EC:5.1.3.22] D M6_Spy0199 L-ribulose-5-phosphate 4-epimerase K03077 araD; L-ribulose-5-phosphate 4-epimerase [EC:5.1.3.4] D M6_Spy0256 Ribulose-phosphate 3-epimerase K01783 rpe; ribulose-phosphate 3-epimerase [EC:5.1.3.1] C 00051 Fructose and mannose metabolism [PATH:spa00051] D M6_Spy1529 Fructokinase K00847 E2.7.1.4; fructokinase [EC:2.7.1.4] D M6_Spy1528 Mannose-6-phosphate isomerase K01809 manA; mannose-6-phosphate isomerase [EC:5.3.1.8] D M6_Spy0976 Non-allosteric 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D M6_Spy0680 1-phosphofructokinase K00882 fruK; 1-phosphofructokinase [EC:2.7.1.56] D M6_Spy1616 Fructose-bisphosphate aldolase K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13] D M6_Spy0530 Triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1] D M6_Spy0681 PTS system, fructose-specific IIABC component K02770 fruA; fructose PTS system EIIBC or EIIC component [EC:2.7.1.202] D M6_Spy0800 PTS system, mannose/fructose family IIA component K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191] D M6_Spy1473 PTS system, mannose-specific IIAB component K02794 manX; mannose PTS system EIIAB component [EC:2.7.1.191] D M6_Spy1474 PTS system, mannose-specific IIC component K02795 manY; mannose PTS system EIIC component D M6_Spy0802 PTS system, mannose/fructose family IIC component K02795 manY; mannose PTS system EIIC component D M6_Spy1475 PTS system, mannose-specific IID component K02796 manZ; mannose PTS system EIID component D M6_Spy0803 PTS system, mannose/fructose family IID component K02796 manZ; mannose PTS system EIID component D M6_Spy0971 PTS system, mannitol-specific IIBC component K02800 mtlA; mannitol PTS system EIICBA or EIICB component [EC:2.7.1.197] C 00052 Galactose metabolism [PATH:spa00052] D M6_Spy0224 UTP--glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D M6_Spy1871 UTP--glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D M6_Spy0927 phosphoglucomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D M6_Spy1278 Glucokinase K25026 glk; glucokinase [EC:2.7.1.2] D M6_Spy1322 Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D M6_Spy1645 Tagatose-6-phosphate kinase K00917 lacC; tagatose 6-phosphate kinase [EC:2.7.1.144] D M6_Spy0976 Non-allosteric 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D M6_Spy1444 Tagatose-bisphosphate aldolase K01635 lacD; tagatose 1,6-diphosphate aldolase [EC:4.1.2.40] D M6_Spy1644 Tagatose-bisphosphate aldolase K01635 lacD; tagatose 1,6-diphosphate aldolase [EC:4.1.2.40] D M6_Spy1446 Galactose-6-phosphate isomerase lacB subunit K01819 E5.3.1.26; galactose-6-phosphate isomerase [EC:5.3.1.26] D M6_Spy1447 Galactose-6-phosphate isomerase lacA subunit K01819 E5.3.1.26; galactose-6-phosphate isomerase [EC:5.3.1.26] D M6_Spy1646 Galactose-6-phosphate isomerase lacB subunit K01819 E5.3.1.26; galactose-6-phosphate isomerase [EC:5.3.1.26] D M6_Spy1647 Galactose-6-phosphate isomerase lacA subunit K01819 E5.3.1.26; galactose-6-phosphate isomerase [EC:5.3.1.26] D M6_Spy1641 6-phospho-beta-galactosidase K01220 E3.2.1.85; 6-phospho-beta-galactosidase [EC:3.2.1.85] D M6_Spy1643 PTS system, lactose-specific IIA component K02786 lacF; lactose PTS system EIIA component [EC:2.7.1.207] D M6_Spy1642 PTS system, lactose-specific IIBC component K02788 lacE; lactose PTS system EIICB component [EC:2.7.1.207] D M6_Spy1532 Sucrose-6-phosphate hydrolase K01193 INV; beta-fructofuranosidase [EC:3.2.1.26] D M6_Spy0544 PTS system, N-acetylgalactosamine-specific IIA component K02744 agaF; N-acetylgalactosamine PTS system EIIA component [EC:2.7.1.-] D M6_Spy0542 PTS system, N-acetylgalactosamine-specific IIB component K02745 agaV; N-acetylgalactosamine PTS system EIIB component [EC:2.7.1.-] D M6_Spy0541 PTS system, N-acetylgalactosamine-specific IIC component K02746 agaW; N-acetylgalactosamine PTS system EIIC component D M6_Spy0540 PTS system, N-acetylgalactosamine-specific IID component K02747 agaE; N-acetylgalactosamine PTS system EIID component D M6_Spy0565 Galactosamine-6-phosphate deaminase (isomerizing) K02082 agaS; D-galactosamine 6-phosphate deaminase/isomerase [EC:3.5.99.-] C 00053 Ascorbate and aldarate metabolism [PATH:spa00053] D M6_Spy1870 UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D M6_Spy0483 UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D M6_Spy0196 PTS system, 3-keto-L-gulonate specific IIA component K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194] D M6_Spy1672 Transcription antiterminator, BglG family K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194] D M6_Spy0195 PTS system, 3-keto-L-gulonate specific IIB component K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194] D M6_Spy1671 PTS system IIB component K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194] D M6_Spy1670 Putative transport protein K03475 ulaA; ascorbate PTS system EIIC component D M6_Spy0194 PTS system, 3-keto-L-gulonate specific IIC component K03475 ulaA; ascorbate PTS system EIIC component D M6_Spy0202 Metal-dependent hydrolase K03476 ulaG; L-ascorbate 6-phosphate lactonase [EC:3.1.1.-] D M6_Spy0197 3-keto-L-gulonate-6-phosphate decarboxylase K03078 ulaD; 3-dehydro-L-gulonate-6-phosphate decarboxylase [EC:4.1.1.85] D M6_Spy0198 L-xylulose 5-phosphate 3-epimerase K03079 ulaE; L-ribulose-5-phosphate 3-epimerase [EC:5.1.3.22] D M6_Spy0199 L-ribulose-5-phosphate 4-epimerase K03077 araD; L-ribulose-5-phosphate 4-epimerase [EC:5.1.3.4] C 00500 Starch and sucrose metabolism [PATH:spa00500] D M6_Spy1531 PTS system, sucrose-specific IIABC component K02810 scrA; sucrose PTS system EIIBCA or EIIBC component [EC:2.7.1.211] D M6_Spy1532 Sucrose-6-phosphate hydrolase K01193 INV; beta-fructofuranosidase [EC:3.2.1.26] D M6_Spy0224 UTP--glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D M6_Spy1871 UTP--glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D M6_Spy1331 Beta-glucosidase K05350 bglB; beta-glucosidase [EC:3.2.1.21] D M6_Spy1050 PTS system, cellobiose-specific IIA component K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205] D M6_Spy1746 PTS system, cellobiose-specific IIA component K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205] D M6_Spy1051 PTS system, cellobiose-specific IIB component K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205] D M6_Spy1745 PTS system, cellobiose-specific IIB component K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205] D M6_Spy1048 PTS system, cellobiose-specific IIC component K02761 celB; cellobiose PTS system EIIC component D M6_Spy1744 PTS system, cellobiose-specific IIC component K02761 celB; cellobiose PTS system EIIC component D M6_Spy0500 6-phospho-beta-glucosidase K01223 E3.2.1.86B; 6-phospho-beta-glucosidase [EC:3.2.1.86] D M6_Spy1054 Beta-glucosidase K01223 E3.2.1.86B; 6-phospho-beta-glucosidase [EC:3.2.1.86] D M6_Spy1029 Glycogen phosphorylase K00688 PYG; glycogen phosphorylase [EC:2.4.1.1] D M6_Spy1030 4-alpha-glucanotransferase K00705 malQ; 4-alpha-glucanotransferase [EC:2.4.1.25] D M6_Spy1698 PTS system, glucose-specific IIABC component K20108 malT; maltose PTS system EIICB or EIICBA component [EC:2.7.1.208] D M6_Spy1697 Exodeoxyribonuclease III K06896 mapP; maltose 6'-phosphate phosphatase [EC:3.1.3.90] D M6_Spy1783 PTS system, trehalose-specific IIBC component K02819 treB; trehalose PTS system EIIBC or EIIBCA component [EC:2.7.1.201] D M6_Spy1782 Trehalose-6-phosphate hydrolase K01226 treC; trehalose-6-phosphate hydrolase [EC:3.2.1.93] D M6_Spy0927 phosphoglucomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D M6_Spy1278 Glucokinase K25026 glk; glucokinase [EC:2.7.1.2] D M6_Spy0219 Glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9] D M6_Spy1529 Fructokinase K00847 E2.7.1.4; fructokinase [EC:2.7.1.4] C 00520 Amino sugar and nucleotide sugar metabolism [PATH:spa00520] D M6_Spy1436 N-acetylglucosamine-6-phosphate deacetylase K01443 nagA; N-acetylglucosamine-6-phosphate deacetylase [EC:3.5.1.25] D M6_Spy1114 Glucosamine-6-phosphate isomerase K02564 nagB; glucosamine-6-phosphate deaminase [EC:3.5.99.6] D M6_Spy1529 Fructokinase K00847 E2.7.1.4; fructokinase [EC:2.7.1.4] D M6_Spy0972 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16] D M6_Spy0788 Phosphoglucosamine mutase K03431 glmM; phosphoglucosamine mutase [EC:5.4.2.10] D M6_Spy0386 Glucosamine-1-phosphate acetyltransferase K04042 glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157] D M6_Spy0601 UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] D M6_Spy1081 UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] D M6_Spy0823 UDP-N-acetylenolpyruvoylglucosamine reductase K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98] D M6_Spy0243 N-acetylmannosamine-6-phosphate 2-epimerase K01788 nanE; N-acylglucosamine-6-phosphate 2-epimerase [EC:5.1.3.9] D M6_Spy0249 N-acetylneuraminate lyase K01639 E4.1.3.3; N-acetylneuraminate lyase [EC:4.1.3.3] D M6_Spy1278 Glucokinase K25026 glk; glucokinase [EC:2.7.1.2] D M6_Spy0927 phosphoglucomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D M6_Spy0224 UTP--glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D M6_Spy1871 UTP--glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D M6_Spy1870 UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D M6_Spy0483 UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D M6_Spy0800 PTS system, mannose/fructose family IIA component K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191] D M6_Spy1473 PTS system, mannose-specific IIAB component K02794 manX; mannose PTS system EIIAB component [EC:2.7.1.191] D M6_Spy1474 PTS system, mannose-specific IIC component K02795 manY; mannose PTS system EIIC component D M6_Spy0802 PTS system, mannose/fructose family IIC component K02795 manY; mannose PTS system EIIC component D M6_Spy1475 PTS system, mannose-specific IID component K02796 manZ; mannose PTS system EIID component D M6_Spy0803 PTS system, mannose/fructose family IID component K02796 manZ; mannose PTS system EIID component D M6_Spy0219 Glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9] D M6_Spy1528 Mannose-6-phosphate isomerase K01809 manA; mannose-6-phosphate isomerase [EC:5.3.1.8] C 00620 Pyruvate metabolism [PATH:spa00620] D M6_Spy0776 Pyruvate dehydrogenase E1 component alpha subunit K00161 PDHA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1] D M6_Spy0777 Pyruvate dehydrogenase E1 component beta subunit K00162 PDHB; pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1] D M6_Spy0778 Dihydrolipoamide acetyltransferase K00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12] D M6_Spy0779 Dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D M6_Spy1581 Formate acetyltransferase K00656 E2.3.1.54; formate C-acetyltransferase [EC:2.3.1.54] D M6_Spy0088 Alcohol dehydrogenase K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1] D M6_Spy0090 Alcohol dehydrogenase K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1] D M6_Spy0832 Zn-dependent alcohol dehydrogenases and related dehydrogenases K00001 E1.1.1.1; alcohol dehydrogenase [EC:1.1.1.1] D M6_Spy0142 Acetate kinase K00925 ackA; acetate kinase [EC:2.7.2.1] D M6_Spy0848 Phosphate acetyltransferase K00625 pta; phosphate acetyltransferase [EC:2.3.1.8] D M6_Spy0975 Pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40] D M6_Spy1478 Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15] D M6_Spy1482 Biotin carboxyl carrier protein of acetyl-CoA carboxylase K02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein D M6_Spy1480 Biotin carboxylase K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14] D M6_Spy1479 Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta K01963 accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15] D M6_Spy0324 Acylphosphatase K01512 acyP; acylphosphatase [EC:3.6.1.7] D M6_Spy0869 L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27] D M6_Spy0448 Lactoylglutathione lyase K01759 GLO1; lactoylglutathione lyase [EC:4.4.1.5] D M6_Spy0554 Hydroxyacylglutathione hydrolase K01069 gloB; hydroxyacylglutathione hydrolase [EC:3.1.2.6] D M6_Spy0831 NAD-dependent malic enzyme K00027 ME2; malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38] D M6_Spy0883 Oxaloacetate decarboxylase alpha chain K01571 oadA; oxaloacetate decarboxylase (Na+ extruding) subunit alpha [EC:7.2.4.2] D M6_Spy0898 Oxaloacetate decarboxylase alpha chain K01571 oadA; oxaloacetate decarboxylase (Na+ extruding) subunit alpha [EC:7.2.4.2] D M6_Spy0886 Oxaloacetate decarboxylase beta chain K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1] D M6_Spy0892 Oxaloacetate decarboxylase beta chain K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1] D M6_Spy0884 Hypothetical membrane associated protein K01573 oadG; oxaloacetate decarboxylase (Na+ extruding) subunit gamma D M6_Spy0526 Phosphoenolpyruvate carboxylase K01595 ppc; phosphoenolpyruvate carboxylase [EC:4.1.1.31] D M6_Spy0166 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy1390 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy0466 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] C 00630 Glyoxylate and dicarboxylate metabolism [PATH:spa00630] D M6_Spy0166 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy1390 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy0466 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy1607 Glutamine synthetase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D M6_Spy0863 Serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1] D M6_Spy0779 Dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D M6_Spy1628 Glycerate kinase K00865 glxK; glycerate 2-kinase [EC:2.7.1.165] D M6_Spy0548 4-Hydroxy-2-oxoglutarate aldolase K01625 eda; 2-dehydro-3-deoxyphosphogluconate aldolase / (4S)-4-hydroxy-2-oxoglutarate aldolase [EC:4.1.2.14 4.1.3.42] C 00640 Propanoate metabolism [PATH:spa00640] D M6_Spy0142 Acetate kinase K00925 ackA; acetate kinase [EC:2.7.2.1] D M6_Spy0848 Phosphate acetyltransferase K00625 pta; phosphate acetyltransferase [EC:2.3.1.8] D M6_Spy0779 Dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D M6_Spy1581 Formate acetyltransferase K00656 E2.3.1.54; formate C-acetyltransferase [EC:2.3.1.54] D M6_Spy1478 Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15] D M6_Spy1482 Biotin carboxyl carrier protein of acetyl-CoA carboxylase K02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein D M6_Spy1480 Biotin carboxylase K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14] D M6_Spy1479 Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta K01963 accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15] D M6_Spy0869 L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27] D M6_Spy1741 Glycerol dehydrogenase K00005 gldA; glycerol dehydrogenase [EC:1.1.1.6] C 00650 Butanoate metabolism [PATH:spa00650] D M6_Spy0166 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy1390 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy0466 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy1391 Acetate CoA-transferase alpha subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] D M6_Spy0167 Acetate CoA-transferase alpha subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] D M6_Spy1392 Acetate CoA-transferase beta subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] D M6_Spy0168 Acetate CoA-transferase beta subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] D M6_Spy0088 Alcohol dehydrogenase K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1] D M6_Spy0886 Oxaloacetate decarboxylase beta chain K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1] D M6_Spy0892 Oxaloacetate decarboxylase beta chain K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1] D M6_Spy0885 Biotin carboxyl carrier protein of oxaloacetate decarboxylase K23351 gcdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma D M6_Spy0891 Biotin carboxyl carrier protein of oxaloacetate decarboxylase K23351 gcdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma D M6_Spy0807 Succinate-semialdehyde dehydrogenase [NADP+] K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20] D M6_Spy1581 Formate acetyltransferase K00656 E2.3.1.54; formate C-acetyltransferase [EC:2.3.1.54] D M6_Spy0704 Hydroxymethylglutaryl-CoA synthase K01641 HMGCS; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10] D M6_Spy1393 D-beta-hydroxybutyrate dehydrogenase K00019 BDH1; 3-hydroxybutyrate dehydrogenase [EC:1.1.1.30] D M6_Spy0833 Zn-dependent alcohol dehydrogenases and related dehydrogenases K18369 adh2; alcohol dehydrogenase [EC:1.1.1.-] D M6_Spy0555 (R,R)-butanediol dehydrogenase K03366 butA; meso-butanediol dehydrogenase / (S,S)-butanediol dehydrogenase / diacetyl reductase [EC:1.1.1.- 1.1.1.76 1.1.1.304] C 00660 C5-Branched dibasic acid metabolism C 00562 Inositol phosphate metabolism [PATH:spa00562] D M6_Spy0947 Myo-inositol-1(or 4)-monophosphatase K01092 E3.1.3.25; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25] D M6_Spy0384 NAD-dependent oxidoreductase K22230 iolU; scyllo-inositol 2-dehydrogenase (NADP+) [EC:1.1.1.-] D M6_Spy0530 Triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1] B B 09102 Energy metabolism C 00190 Oxidative phosphorylation [PATH:spa00190] D M6_Spy0596 ATP synthase alpha chain K02111 ATPF1A; F-type H+/Na+-transporting ATPase subunit alpha [EC:7.1.2.2 7.2.2.1] D M6_Spy0598 ATP synthase beta chain K02112 ATPF1B; F-type H+/Na+-transporting ATPase subunit beta [EC:7.1.2.2 7.2.2.1] D M6_Spy0597 ATP synthase gamma chain K02115 ATPF1G; F-type H+-transporting ATPase subunit gamma D M6_Spy0595 ATP synthase delta chain K02113 ATPF1D; F-type H+-transporting ATPase subunit delta D M6_Spy0599 ATP synthase epsilon chain K02114 ATPF1E; F-type H+-transporting ATPase subunit epsilon D M6_Spy0593 ATP synthase A chain K02108 ATPF0A; F-type H+-transporting ATPase subunit a D M6_Spy0594 ATP synthase B chain K02109 ATPF0B; F-type H+-transporting ATPase subunit b D M6_Spy0592 ATP synthase C chain K02110 ATPF0C; F-type H+-transporting ATPase subunit c D M6_Spy0178 V-type sodium ATP synthase subunit A K02117 ATPVA; V/A-type H+/Na+-transporting ATPase subunit A [EC:7.1.2.2 7.2.2.1] D M6_Spy0179 V-type sodium ATP synthase subunit B K02118 ATPVB; V/A-type H+/Na+-transporting ATPase subunit B D M6_Spy0176 V-type sodium ATP synthase subunit C K02119 ATPVC; V/A-type H+/Na+-transporting ATPase subunit C D M6_Spy0180 V-type sodium ATP synthase subunit D K02120 ATPVD; V/A-type H+/Na+-transporting ATPase subunit D D M6_Spy0175 V-type sodium ATP synthase subunit E K02121 ATPVE; V/A-type H+/Na+-transporting ATPase subunit E D M6_Spy0177 V-type sodium ATP synthase subunit F K02122 ATPVF; V/A-type H+/Na+-transporting ATPase subunit F D M6_Spy0172 Hypothetical protein K02107 ATPVG; V/A-type H+/Na+-transporting ATPase subunit G/H D M6_Spy0173 V-type sodium ATP synthase subunit I K02123 ATPVI; V/A-type H+/Na+-transporting ATPase subunit I D M6_Spy0174 V-type sodium ATP synthase subunit K K02124 ATPVK; V/A-type H+/Na+-transporting ATPase subunit K D M6_Spy0345 Manganese-dependent inorganic pyrophosphatase K15986 ppaC; manganese-dependent inorganic pyrophosphatase [EC:3.6.1.1] C 00195 Photosynthesis C 00196 Photosynthesis - antenna proteins C 00710 Carbon fixation in photosynthetic organisms C 00720 Carbon fixation pathways in prokaryotes C 00680 Methane metabolism [PATH:spa00680] D M6_Spy0863 Serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1] D M6_Spy0577 Enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] D M6_Spy0526 Phosphoenolpyruvate carboxylase K01595 ppc; phosphoenolpyruvate carboxylase [EC:4.1.1.31] D M6_Spy1616 Fructose-bisphosphate aldolase K01624 FBA; fructose-bisphosphate aldolase, class II [EC:4.1.2.13] D M6_Spy0976 Non-allosteric 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D M6_Spy0142 Acetate kinase K00925 ackA; acetate kinase [EC:2.7.2.1] D M6_Spy0848 Phosphate acetyltransferase K00625 pta; phosphate acetyltransferase [EC:2.3.1.8] D M6_Spy1190 Phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] D M6_Spy0477 Hypothetical protein K12234 cofE; coenzyme F420-0:L-glutamate ligase / coenzyme F420-1:gamma-L-glutamate ligase [EC:6.3.2.31 6.3.2.34] C 00910 Nitrogen metabolism [PATH:spa00910] D M6_Spy1607 Glutamine synthetase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D M6_Spy1291 Carbamate kinase K00926 arcC; carbamate kinase [EC:2.7.2.2] D M6_Spy0232 Carbonic anhydrase K01673 cynT; carbonic anhydrase [EC:4.2.1.1] C 00920 Sulfur metabolism [PATH:spa00920] D M6_Spy0567 Phosphoesterase, DHH family protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3] D M6_Spy1666 Serine acetyltransferase K00640 cysE; serine O-acetyltransferase [EC:2.3.1.30] D M6_Spy1375 Cysteine synthase K01738 cysK; cysteine synthase [EC:2.5.1.47] B B 09103 Lipid metabolism C 00061 Fatty acid biosynthesis [PATH:spa00061] D M6_Spy1478 Acetyl-coenzyme A carboxylase carboxyl transferase subunit alpha K01962 accA; acetyl-CoA carboxylase carboxyl transferase subunit alpha [EC:6.4.1.2 2.1.3.15] D M6_Spy1482 Biotin carboxyl carrier protein of acetyl-CoA carboxylase K02160 accB; acetyl-CoA carboxylase biotin carboxyl carrier protein D M6_Spy1480 Biotin carboxylase K01961 accC; acetyl-CoA carboxylase, biotin carboxylase subunit [EC:6.4.1.2 6.3.4.14] D M6_Spy1479 Acetyl-coenzyme A carboxylase carboxyl transferase subunit beta K01963 accD; acetyl-CoA carboxylase carboxyl transferase subunit beta [EC:6.4.1.2 2.1.3.15] D M6_Spy1487 Acyl carrier protein K02078 acpP; acyl carrier protein D M6_Spy0070 Acyl carrier protein K02078 acpP; acyl carrier protein D M6_Spy1485 Malonyl-CoA-[acyl-carrier-protein] transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39] D M6_Spy1488 3-oxoacyl-[acyl-carrier-protein] synthase III K00648 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180] D M6_Spy1483 3-oxoacyl-[acyl-carrier-protein] synthase K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179] D M6_Spy0383 Short chain dehydrogenase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D M6_Spy1484 3-oxoacyl-[acyl-carrier protein] reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D M6_Spy1481 (3R)-hydroxyacyl-[acyl carrier protein] dehydratase K02372 fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59] D M6_Spy1486 Enoyl-[acyl-carrier protein] reductase (NADH) K02371 fabK; enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9] D M6_Spy1490 Enoyl-CoA hydratase K18474 fabM; trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:5.3.3.14] D M6_Spy0467 Long-chain-fatty-acid--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3] C 00062 Fatty acid elongation C 00071 Fatty acid degradation [PATH:spa00071] D M6_Spy0166 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy1390 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy0466 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy0467 Long-chain-fatty-acid--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3] D M6_Spy0088 Alcohol dehydrogenase K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1] D M6_Spy0090 Alcohol dehydrogenase K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1] D M6_Spy0832 Zn-dependent alcohol dehydrogenases and related dehydrogenases K00001 E1.1.1.1; alcohol dehydrogenase [EC:1.1.1.1] C 00073 Cutin, suberine and wax biosynthesis C 00100 Steroid biosynthesis C 00120 Primary bile acid biosynthesis C 00121 Secondary bile acid biosynthesis C 00140 Steroid hormone biosynthesis C 00561 Glycerolipid metabolism [PATH:spa00561] D M6_Spy1628 Glycerate kinase K00865 glxK; glycerate 2-kinase [EC:2.7.1.165] D M6_Spy0461 Dihydroxyacetone kinase K05878 dhaK; phosphoenolpyruvate---glycerone phosphotransferase subunit DhaK [EC:2.7.1.121] D M6_Spy0462 Dihydroxyacetone kinase K05879 dhaL; phosphoenolpyruvate---glycerone phosphotransferase subunit DhaL [EC:2.7.1.121] D M6_Spy0463 Dihydroxyacetone kinase phosphotransfer protein K05881 dhaM; phosphoenolpyruvate---glycerone phosphotransferase subunit DhaM [EC:2.7.1.121] D M6_Spy1741 Glycerol dehydrogenase K00005 gldA; glycerol dehydrogenase [EC:1.1.1.6] D M6_Spy1429 Glycerol kinase K00864 glpK; glycerol kinase [EC:2.7.1.30] D M6_Spy0069 Fatty acid/phospholipid synthesis protein plsX K03621 plsX; phosphate acyltransferase [EC:2.3.1.274] D M6_Spy0727 Hypothetical membrane spanning protein K08591 plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275] D M6_Spy1177 1-acyl-sn-glycerol-3-phosphate acyltransferase K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51] D M6_Spy0591 Diacylglycerol kinase family K07029 dagK; diacylglycerol kinase (ATP) [EC:2.7.1.107] D M6_Spy0453 1,2-diacylglycerol 3-glucosyltransferase K19002 mgs; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337] D M6_Spy0452 Glycosyltransferase K13677 dgs; 1,2-diacylglycerol-3-alpha-glucose alpha-1,2-glucosyltransferase [EC:2.4.1.208] D M6_Spy0639 Phosphoglycerol transferase K19005 ltaS; lipoteichoic acid synthase [EC:2.7.8.20] C 00564 Glycerophospholipid metabolism [PATH:spa00564] D M6_Spy0225 Glycerol-3-phosphate dehydrogenase [NAD(P)+] K00057 gpsA; glycerol-3-phosphate dehydrogenase (NAD(P)+) [EC:1.1.1.94] D M6_Spy1428 Alpha-glycerophosphate oxidase K00105 E1.1.3.21; alpha-glycerophosphate oxidase [EC:1.1.3.21] D M6_Spy0727 Hypothetical membrane spanning protein K08591 plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275] D M6_Spy1177 1-acyl-sn-glycerol-3-phosphate acyltransferase K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51] D M6_Spy0591 Diacylglycerol kinase family K07029 dagK; diacylglycerol kinase (ATP) [EC:2.7.1.107] D M6_Spy0666 Glycerophosphoryl diester phosphodiesterase K01126 E3.1.4.46; glycerophosphoryl diester phosphodiesterase [EC:3.1.4.46] D M6_Spy1683 Phosphatidate cytidylyltransferase K00981 E2.7.7.41; phosphatidate cytidylyltransferase [EC:2.7.7.41] D M6_Spy1864 CDP-diacylglycerol--glycerol-3-phosphate 3-phosphatidyltransferase K00995 pgsA; CDP-diacylglycerol---glycerol-3-phosphate 3-phosphatidyltransferase [EC:2.7.8.5] D M6_Spy1572 Phosphatidylglycerophosphatase B K01096 pgpB; phosphatidylglycerophosphatase B [EC:3.1.3.27 3.6.1.75 3.1.3.4 3.6.1.27] D M6_Spy0915 Cardiolipin synthetase K06131 clsA_B; cardiolipin synthase A/B [EC:2.7.8.-] C 00565 Ether lipid metabolism C 00600 Sphingolipid metabolism D M6_Spy1322 Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] C 00590 Arachidonic acid metabolism C 00591 Linoleic acid metabolism C 00592 alpha-Linolenic acid metabolism C 01040 Biosynthesis of unsaturated fatty acids B B 09104 Nucleotide metabolism C 00230 Purine metabolism [PATH:spa00230] D M6_Spy0387 Phosphohydrolase (MutT/nudix family protein) K01515 nudF; ADP-ribose diphosphatase [EC:3.6.1.13 3.6.1.-] D M6_Spy0713 Phosphopentomutase K01839 deoB; phosphopentomutase [EC:5.4.2.7] D M6_Spy0927 phosphoglucomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D M6_Spy0018 Ribose-phosphate pyrophosphokinase K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1] D M6_Spy0843 Ribose-phosphate pyrophosphokinase K00948 PRPS; ribose-phosphate pyrophosphokinase [EC:2.7.6.1] D M6_Spy0073 Amidophosphoribosyltransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14] D M6_Spy0078 Phosphoribosylamine--glycine ligase K01945 purD; phosphoribosylamine---glycine ligase [EC:6.3.4.13] D M6_Spy0075 Phosphoribosylglycinamide formyltransferase K11175 purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2] D M6_Spy0072 Phosphoribosylformylglycinamidine synthase K01952 PFAS; phosphoribosylformylglycinamidine synthase [EC:6.3.5.3] D M6_Spy0074 Phosphoribosylformylglycinamidine cyclo-ligase K01933 purM; phosphoribosylformylglycinamidine cyclo-ligase [EC:6.3.3.1] D M6_Spy0080 Phosphoribosylaminoimidazole carboxylase NCAIR mutase subunit K01589 purK; 5-(carboxyamino)imidazole ribonucleotide synthase [EC:6.3.4.18] D M6_Spy0079 Phosphoribosylaminoimidazole carboxylase carboxyltransferase subunit K01588 purE; 5-(carboxyamino)imidazole ribonucleotide mutase [EC:5.4.99.18] D M6_Spy0071 Phosphoribosylaminoimidazole-succinocarboxamide synthase K01923 purC; phosphoribosylaminoimidazole-succinocarboxamide synthase [EC:6.3.2.6] D M6_Spy0082 Adenylosuccinate lyase K01756 purB; adenylosuccinate lyase [EC:4.3.2.2] D M6_Spy0076 phosphoribosylaminoimidazolecarboxamide formyltransferase K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10] D M6_Spy0754 Adenine phosphoribosyltransferase K00759 APRT; adenine phosphoribosyltransferase [EC:2.4.2.7] D M6_Spy0695 5'-nucleotidase K01081 E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5] D M6_Spy0715 Purine nucleoside phosphorylase K03783 punA; purine-nucleoside phosphorylase [EC:2.4.2.1] D M6_Spy0716 Purine nucleoside phosphorylase K03784 deoD; purine-nucleoside phosphorylase [EC:2.4.2.1] D M6_Spy0012 Hypoxanthine-guanine phosphoribosyltransferase K00760 hprT; hypoxanthine phosphoribosyltransferase [EC:2.4.2.8] D M6_Spy1875 Inosine-5'-monophosphate dehydrogenase K00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205] D M6_Spy0330 Xanthosine triphosphate pyrophosphatase K01519 rdgB; XTP/dITP diphosphohydrolase [EC:3.6.1.66] D M6_Spy0854 Xanthine phosphoribosyltransferase K03816 xpt; xanthine phosphoribosyltransferase [EC:2.4.2.22] D M6_Spy0908 GMP synthase [glutamine-hydrolyzing] K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2] D M6_Spy0853 GMP reductase K00364 guaC; GMP reductase [EC:1.7.1.7] D M6_Spy1387 Guanylate kinase K00942 gmk; guanylate kinase [EC:2.7.4.8] D M6_Spy1097 Ribonucleoside-diphosphate reductase alpha chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] D M6_Spy0374 Ribonucleoside-diphosphate reductase alpha chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] D M6_Spy1098 Ribonucleoside-diphosphate reductase beta chain K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] D M6_Spy0372 Ribonucleoside-diphosphate reductase beta chain K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] D M6_Spy1792 Anaerobic ribonucleoside-triphosphate reductase K21636 nrdD; ribonucleoside-triphosphate reductase (formate) [EC:1.1.98.6] D M6_Spy1694 GTP pyrophosphokinase K01139 spoT; GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2] D M6_Spy0845 GTP pyrophosphokinase K07816 E2.7.6.5; GTP pyrophosphokinase [EC:2.7.6.5] D M6_Spy0696 GTP pyrophosphokinase K07816 E2.7.6.5; GTP pyrophosphokinase [EC:2.7.6.5] D M6_Spy0183 Adenylosuccinate synthetase K01939 purA; adenylosuccinate synthase [EC:6.3.4.4] D M6_Spy0114 Adenylate kinase K00939 adk; adenylate kinase [EC:2.7.4.3] D M6_Spy1291 Carbamate kinase K00926 arcC; carbamate kinase [EC:2.7.2.2] C 00240 Pyrimidine metabolism [PATH:spa00240] D M6_Spy0662 Carbamoyl-phosphate synthase large chain K01955 carB; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5] D M6_Spy0660 Carbamoyl-phosphate synthase small chain K01956 carA; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5] D M6_Spy0659 Aspartate carbamoyltransferase K00609 pyrB; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2] D M6_Spy0726 Dihydroorotase K01465 URA4; dihydroorotase [EC:3.5.2.3] D M6_Spy1191 Dihydroorotate dehydrogenase K00226 pyrD; dihydroorotate dehydrogenase (fumarate) [EC:1.3.98.1] D M6_Spy0721 Orotate phosphoribosyltransferase K00762 pyrE; orotate phosphoribosyltransferase [EC:2.4.2.10] D M6_Spy0720 Orotidine 5'-phosphate decarboxylase K01591 pyrF; orotidine-5'-phosphate decarboxylase [EC:4.1.1.23] D M6_Spy0404 Uridylate kinase K09903 pyrH; uridylate kinase [EC:2.7.4.22] D M6_Spy1618 CTP synthase K01937 pyrG; CTP synthase [EC:6.3.4.2] D M6_Spy0635 Cytidylate kinase K00945 cmk; CMP/dCMP kinase [EC:2.7.4.25] D M6_Spy1090 Uridine kinase K00876 udk; uridine kinase [EC:2.7.1.48] D M6_Spy0695 5'-nucleotidase K01081 E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5] D M6_Spy1599 Uridine phosphorylase K00757 udp; uridine phosphorylase [EC:2.4.2.3] D M6_Spy0353 Uracil phosphoribosyltransferase K00761 upp; uracil phosphoribosyltransferase [EC:2.4.2.9] D M6_Spy0657 Uracil phosphoribosyltransferase K02825 pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9] D M6_Spy0932 Cytidine deaminase K01489 cdd; cytidine deaminase [EC:3.5.4.5] D M6_Spy1792 Anaerobic ribonucleoside-triphosphate reductase K21636 nrdD; ribonucleoside-triphosphate reductase (formate) [EC:1.1.98.6] D M6_Spy1097 Ribonucleoside-diphosphate reductase alpha chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] D M6_Spy0374 Ribonucleoside-diphosphate reductase alpha chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] D M6_Spy1098 Ribonucleoside-diphosphate reductase beta chain K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] D M6_Spy0372 Ribonucleoside-diphosphate reductase beta chain K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] D M6_Spy1537 ComE operon protein 2 K01493 comEB; dCMP deaminase [EC:3.5.4.12] D M6_Spy0356 Thymidylate kinase K00943 tmk; dTMP kinase [EC:2.7.4.9] D M6_Spy0230 Deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23] D M6_Spy0858 Thymidine kinase K00857 tdk; thymidine kinase [EC:2.7.1.21] D M6_Spy0705 Thymidylate synthase K00560 thyA; thymidylate synthase [EC:2.1.1.45] D M6_Spy0849 Short chain dehydrogenase K16066 ydfG; 3-hydroxy acid dehydrogenase / malonic semialdehyde reductase [EC:1.1.1.381 1.1.1.-] B B 09105 Amino acid metabolism C 00250 Alanine, aspartate and glutamate metabolism [PATH:spa00250] D M6_Spy1509 L-asparaginase K01424 E3.5.1.1; L-asparaginase [EC:3.5.1.1] D M6_Spy1290 Aspartate--ammonia ligase K01914 asnA; aspartate--ammonia ligase [EC:6.3.1.1] D M6_Spy0557 Aspartate aminotransferase K22457 E2.6.1.14; asparagine---oxo-acid transaminase [EC:2.6.1.14] D M6_Spy1506 Aspartate aminotransferase K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2] D M6_Spy0183 Adenylosuccinate synthetase K01939 purA; adenylosuccinate synthase [EC:6.3.4.4] D M6_Spy0082 Adenylosuccinate lyase K01756 purB; adenylosuccinate lyase [EC:4.3.2.2] D M6_Spy0659 Aspartate carbamoyltransferase K00609 pyrB; aspartate carbamoyltransferase catalytic subunit [EC:2.1.3.2] D M6_Spy0807 Succinate-semialdehyde dehydrogenase [NADP+] K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20] D M6_Spy1607 Glutamine synthetase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D M6_Spy0662 Carbamoyl-phosphate synthase large chain K01955 carB; carbamoyl-phosphate synthase large subunit [EC:6.3.5.5] D M6_Spy0660 Carbamoyl-phosphate synthase small chain K01956 carA; carbamoyl-phosphate synthase small subunit [EC:6.3.5.5] D M6_Spy0972 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16] D M6_Spy0073 Amidophosphoribosyltransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14] C 00260 Glycine, serine and threonine metabolism [PATH:spa00260] D M6_Spy0863 Serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1] D M6_Spy1628 Glycerate kinase K00865 glxK; glycerate 2-kinase [EC:2.7.1.165] D M6_Spy1190 Phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] D M6_Spy0849 Short chain dehydrogenase K16066 ydfG; 3-hydroxy acid dehydrogenase / malonic semialdehyde reductase [EC:1.1.1.381 1.1.1.-] D M6_Spy0779 Dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D M6_Spy1858 L-serine dehydratase beta subunit K01752 E4.3.1.17; L-serine dehydratase [EC:4.3.1.17] D M6_Spy1859 L-serine dehydratase alpha subunit K01752 E4.3.1.17; L-serine dehydratase [EC:4.3.1.17] C 00270 Cysteine and methionine metabolism [PATH:spa00270] D M6_Spy1666 Serine acetyltransferase K00640 cysE; serine O-acetyltransferase [EC:2.3.1.30] D M6_Spy1375 Cysteine synthase K01738 cysK; cysteine synthase [EC:2.5.1.47] D M6_Spy0192 Cystathionine beta-lyase K01760 metC; cysteine-S-conjugate beta-lyase [EC:4.4.1.13] D M6_Spy1082 S-adenosylmethionine synthetase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6] D M6_Spy1147 S-adenosylmethionine synthetase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6] D M6_Spy0479 S-adenosylmethionine synthetase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6] D M6_Spy0389 5'-methylthioadenosine nucleosidase K01243 mtnN; adenosylhomocysteine nucleosidase [EC:3.2.2.9] D M6_Spy1087 GAF domain-containing proteins K08968 msrC; L-methionine (R)-S-oxide reductase [EC:1.8.4.14] D M6_Spy1143 DNA-cytosine methyltransferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D M6_Spy1160 Type II restriction-modification system methylation subunit K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D M6_Spy1395 Autoinducer-2 production protein K07173 luxS; S-ribosylhomocysteine lyase [EC:4.4.1.21] D M6_Spy0730 Branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] D M6_Spy0869 L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27] D M6_Spy1858 L-serine dehydratase beta subunit K01752 E4.3.1.17; L-serine dehydratase [EC:4.3.1.17] D M6_Spy1859 L-serine dehydratase alpha subunit K01752 E4.3.1.17; L-serine dehydratase [EC:4.3.1.17] C 00280 Valine, leucine and isoleucine degradation [PATH:spa00280] D M6_Spy0730 Branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] D M6_Spy0779 Dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D M6_Spy0166 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy1390 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy0466 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy0704 Hydroxymethylglutaryl-CoA synthase K01641 HMGCS; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10] C 00290 Valine, leucine and isoleucine biosynthesis [PATH:spa00290] D M6_Spy0730 Branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] D M6_Spy1506 Aspartate aminotransferase K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2] C 00300 Lysine biosynthesis D M6_Spy1184 UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10] C 00310 Lysine degradation [PATH:spa00310] D M6_Spy0779 Dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D M6_Spy0166 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy1390 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy0466 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy0807 Succinate-semialdehyde dehydrogenase [NADP+] K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20] D M6_Spy1391 Acetate CoA-transferase alpha subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] D M6_Spy0167 Acetate CoA-transferase alpha subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] D M6_Spy1392 Acetate CoA-transferase beta subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] D M6_Spy0168 Acetate CoA-transferase beta subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] C 00220 Arginine biosynthesis [PATH:spa00220] D M6_Spy1294 Ornithine carbamoyltransferase K00611 OTC; ornithine carbamoyltransferase [EC:2.1.3.3] D M6_Spy1296 Arginine deiminase K01478 arcA; arginine deiminase [EC:3.5.3.6] D M6_Spy1607 Glutamine synthetase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D M6_Spy1291 Carbamate kinase K00926 arcC; carbamate kinase [EC:2.7.2.2] D M6_Spy1506 Aspartate aminotransferase K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2] C 00330 Arginine and proline metabolism [PATH:spa00330] D M6_Spy0722 Amidase family protein K01426 E3.5.1.4; amidase [EC:3.5.1.4] D M6_Spy1702 Amidase family protein K01426 E3.5.1.4; amidase [EC:3.5.1.4] D M6_Spy0144 Pyrroline-5-carboxylate reductase K00286 proC; pyrroline-5-carboxylate reductase [EC:1.5.1.2] D M6_Spy1419 Glutamate 5-kinase K00931 proB; glutamate 5-kinase [EC:2.7.2.11] D M6_Spy1418 Gamma-glutamyl phosphate reductase K00147 proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41] C 00340 Histidine metabolism [PATH:spa00340] D M6_Spy1774 Histidine ammonia-lyase K01745 hutH; histidine ammonia-lyase [EC:4.3.1.3] D M6_Spy1768 Urocanate hydratase K01712 hutU; urocanate hydratase [EC:4.2.1.49] D M6_Spy1767 Imidazolonepropionase K01468 hutI; imidazolonepropionase [EC:3.5.2.7] D M6_Spy1776 Formiminoglutamase K01479 hutG; formiminoglutamase [EC:3.5.3.8] D M6_Spy1769 glutamate formiminotransferase K00603 fctD; glutamate formiminotransferase / 5-formyltetrahydrofolate cyclo-ligase [EC:2.1.2.5 6.3.3.2] C 00350 Tyrosine metabolism [PATH:spa00350] D M6_Spy0088 Alcohol dehydrogenase K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1] D M6_Spy0090 Alcohol dehydrogenase K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1] D M6_Spy0832 Zn-dependent alcohol dehydrogenases and related dehydrogenases K00001 E1.1.1.1; alcohol dehydrogenase [EC:1.1.1.1] D M6_Spy0807 Succinate-semialdehyde dehydrogenase [NADP+] K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20] C 00360 Phenylalanine metabolism D M6_Spy0722 Amidase family protein K01426 E3.5.1.4; amidase [EC:3.5.1.4] D M6_Spy1702 Amidase family protein K01426 E3.5.1.4; amidase [EC:3.5.1.4] C 00380 Tryptophan metabolism [PATH:spa00380] D M6_Spy0779 Dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D M6_Spy0166 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy1390 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy0466 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy0722 Amidase family protein K01426 E3.5.1.4; amidase [EC:3.5.1.4] D M6_Spy1702 Amidase family protein K01426 E3.5.1.4; amidase [EC:3.5.1.4] C 00400 Phenylalanine, tyrosine and tryptophan biosynthesis [PATH:spa00400] D M6_Spy1315 Phospho-2-dehydro-3-deoxyheptonate aldolase K03856 AROA2; 3-deoxy-7-phosphoheptulonate synthase [EC:2.5.1.54] D M6_Spy1316 3-dehydroquinate synthase K01735 aroB; 3-dehydroquinate synthase [EC:4.2.3.4] D M6_Spy0641 3-dehydroquinate dehydratase K03785 aroD; 3-dehydroquinate dehydratase I [EC:4.2.1.10] D M6_Spy0475 Shikimate 5-dehydrogenase K00014 aroE; shikimate dehydrogenase [EC:1.1.1.25] D M6_Spy1072 Shikimate kinase K00891 aroK; shikimate kinase [EC:2.7.1.71] D M6_Spy1073 3-phosphoshikimate 1-carboxyvinyltransferase K00800 aroA; 3-phosphoshikimate 1-carboxyvinyltransferase [EC:2.5.1.19] D M6_Spy0642 Chorismate synthase K01736 aroC; chorismate synthase [EC:4.2.3.5] D M6_Spy1704 Anthranilate synthase component II K01658 trpG; anthranilate synthase component II [EC:4.1.3.27] D M6_Spy0569 Chorismate mutase K04516 AROA1; chorismate mutase [EC:5.4.99.5] B B 09106 Metabolism of other amino acids C 00410 beta-Alanine metabolism C 00430 Taurine and hypotaurine metabolism [PATH:spa00430] D M6_Spy0848 Phosphate acetyltransferase K00625 pta; phosphate acetyltransferase [EC:2.3.1.8] D M6_Spy0142 Acetate kinase K00925 ackA; acetate kinase [EC:2.7.2.1] C 00440 Phosphonate and phosphinate metabolism C 00450 Selenocompound metabolism [PATH:spa00450] D M6_Spy0192 Cystathionine beta-lyase K01760 metC; cysteine-S-conjugate beta-lyase [EC:4.4.1.13] D M6_Spy0275 Cysteine desulfhydrase K11717 sufS; cysteine desulfurase / selenocysteine lyase [EC:2.8.1.7 4.4.1.16] D M6_Spy1406 Thioredoxin reductase K00384 trxB; thioredoxin reductase (NADPH) [EC:1.8.1.9] D M6_Spy0370 Methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10] C 00460 Cyanoamino acid metabolism [PATH:spa00460] D M6_Spy1331 Beta-glucosidase K05350 bglB; beta-glucosidase [EC:3.2.1.21] D M6_Spy1509 L-asparaginase K01424 E3.5.1.1; L-asparaginase [EC:3.5.1.1] D M6_Spy1290 Aspartate--ammonia ligase K01914 asnA; aspartate--ammonia ligase [EC:6.3.1.1] D M6_Spy0863 Serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1] C 00470 D-Amino acid metabolism [PATH:spa00470] D M6_Spy1524 Alanine racemase K01775 alr; alanine racemase [EC:5.1.1.1] D M6_Spy1185 D-alanine--D-alanine ligase K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4] D M6_Spy1043 D-alanine-activating enzyme K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13] D M6_Spy1041 D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13] D M6_Spy0329 Glutamate racemase K01776 murI; glutamate racemase [EC:5.1.1.3] D M6_Spy1274 UDP-N-acetylmuramoylalanine--D-glutamate ligase K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9] C 00480 Glutathione metabolism [PATH:spa00480] D M6_Spy0938 Lysyl aminopeptidase K01256 pepN; aminopeptidase N [EC:3.4.11.2] D M6_Spy0745 Glutathione S-transferase K00799 GST; glutathione S-transferase [EC:2.5.1.18] D M6_Spy0644 Glutathione reductase K00383 GSR; glutathione reductase (NADPH) [EC:1.8.1.7] D M6_Spy0524 Glutathione peroxidase K00432 gpx; glutathione peroxidase [EC:1.11.1.9] B B 09107 Glycan biosynthesis and metabolism C 00510 N-Glycan biosynthesis C 00513 Various types of N-glycan biosynthesis C 00512 Mucin type O-glycan biosynthesis C 00515 Mannose type O-glycan biosynthesis C 00514 Other types of O-glycan biosynthesis C 00532 Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate C 00534 Glycosaminoglycan biosynthesis - heparan sulfate / heparin C 00533 Glycosaminoglycan biosynthesis - keratan sulfate C 00531 Glycosaminoglycan degradation C 00563 Glycosylphosphatidylinositol (GPI)-anchor biosynthesis C 00601 Glycosphingolipid biosynthesis - lacto and neolacto series C 00603 Glycosphingolipid biosynthesis - globo and isoglobo series C 00604 Glycosphingolipid biosynthesis - ganglio series C 00511 Other glycan degradation [PATH:spa00511] D M6_Spy1322 Beta-galactosidase K01190 lacZ; beta-galactosidase [EC:3.2.1.23] D M6_Spy1335 Alpha-mannosidase K01191 MAN2C1; alpha-mannosidase [EC:3.2.1.24] C 00540 Lipopolysaccharide biosynthesis C 00542 O-Antigen repeat unit biosynthesis [PATH:spa00542] D M6_Spy0272 Undecaprenyl-phosphate alpha-N-acetylglucosaminephosphotransferase K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] C 00541 O-Antigen nucleotide sugar biosynthesis [PATH:spa00541] D M6_Spy0224 UTP--glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D M6_Spy1871 UTP--glucose-1-phosphate uridylyltransferase K00963 UGP2; UTP--glucose-1-phosphate uridylyltransferase [EC:2.7.7.9] D M6_Spy1870 UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D M6_Spy0483 UDP-glucose 6-dehydrogenase K00012 UGDH; UDPglucose 6-dehydrogenase [EC:1.1.1.22] D M6_Spy0760 Glucose-1-phosphate thymidylyltransferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24] D M6_Spy0762 dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] D M6_Spy0761 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13] D M6_Spy0619 dTDP-4-dehydrorhamnose reductase K00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133] D M6_Spy1528 Mannose-6-phosphate isomerase K01809 manA; mannose-6-phosphate isomerase [EC:5.3.1.8] D M6_Spy0386 Glucosamine-1-phosphate acetyltransferase K04042 glmU; bifunctional UDP-N-acetylglucosamine pyrophosphorylase / glucosamine-1-phosphate N-acetyltransferase [EC:2.7.7.23 2.3.1.157] C 00550 Peptidoglycan biosynthesis [PATH:spa00550] D M6_Spy0601 UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] D M6_Spy1081 UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] D M6_Spy0823 UDP-N-acetylenolpyruvoylglucosamine reductase K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98] D M6_Spy0318 UDP-N-acetylmuramate--alanine ligase K01924 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8] D M6_Spy1274 UDP-N-acetylmuramoylalanine--D-glutamate ligase K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9] D M6_Spy1185 D-alanine--D-alanine ligase K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4] D M6_Spy1184 UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10] D M6_Spy0414 Diacylglycerol kinase K00887 dgkA; undecaprenol kinase [EC:2.7.1.66] D M6_Spy1684 Undecaprenyl pyrophosphate synthetase K00806 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31] D M6_Spy0270 Bacitracin resistance protein K06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27] D M6_Spy0340 Membrane-associated phospholipid phosphatase K19302 bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27] D M6_Spy1412 Phospho-N-acetylmuramoyl-pentapeptide-transferase K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13] D M6_Spy1273 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227] D M6_Spy1401 Multimodular transpeptidase-transglycosylase PBP 1A K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4] D M6_Spy1753 Multimodular transpeptidase-transglycosylase PBP 2A K12555 pbp2A; penicillin-binding protein 2A [EC:2.4.99.28 3.4.16.4] D M6_Spy0815 D-alanyl-D-alanine carboxypeptidase K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] D M6_Spy0279 D-alanyl-D-alanine carboxypeptidase K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] D M6_Spy1496 D-alanyl-D-alanine carboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14] D M6_Spy0351 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--lysine ligase K05362 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase [EC:6.3.2.7] D M6_Spy0785 UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase K23393 murT; lipid II isoglutaminyl synthase (glutamine-hydrolysing) [EC:6.3.5.13] D M6_Spy0784 Hypothetical membrane associated protein K07009 gatD; lipid II isoglutaminyl synthase (glutamine-hydrolysing) [EC:6.3.5.13] D M6_Spy0909 UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase K05363 murM; serine/alanine adding enzyme [EC:2.3.2.10] D M6_Spy0532 Factor essential for expression of methicillin resistance K05363 murM; serine/alanine adding enzyme [EC:2.3.2.10] D M6_Spy0531 Factor essential for expression of methicillin resistance K12554 murN; alanine adding enzyme [EC:2.3.2.-] D M6_Spy0130 Multimodular transpeptidase-transglycosylase K03693 pbp1b; penicillin-binding protein 1B D M6_Spy1413 Division specific D,D-transpeptidase K12556 pbp2X; penicillin-binding protein 2X C 00552 Teichoic acid biosynthesis [PATH:spa00552] D M6_Spy0270 Bacitracin resistance protein K06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27] D M6_Spy0340 Membrane-associated phospholipid phosphatase K19302 bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27] D M6_Spy0272 Undecaprenyl-phosphate alpha-N-acetylglucosaminephosphotransferase K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] D M6_Spy1043 D-alanine-activating enzyme K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13] D M6_Spy1041 D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13] D M6_Spy1042 DltB K03739 dltB; membrane protein involved in D-alanine export D M6_Spy1040 DltD precursor K03740 dltD; D-alanine transfer protein D M6_Spy1468 Transcriptional regulator, LytR family K01005 tagT_U_V; polyisoprenyl-teichoic acid--peptidoglycan teichoic acid transferase [EC:2.7.8.-] D M6_Spy1071 Transcriptional regulator, LytR family K01005 tagT_U_V; polyisoprenyl-teichoic acid--peptidoglycan teichoic acid transferase [EC:2.7.8.-] D M6_Spy0639 Phosphoglycerol transferase K19005 ltaS; lipoteichoic acid synthase [EC:2.7.8.20] D M6_Spy0453 1,2-diacylglycerol 3-glucosyltransferase K19002 mgs; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337] C 00571 Lipoarabinomannan (LAM) biosynthesis C 00572 Arabinogalactan biosynthesis - Mycobacterium C 00543 Exopolysaccharide biosynthesis [PATH:spa00543] D M6_Spy0272 Undecaprenyl-phosphate alpha-N-acetylglucosaminephosphotransferase K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] D M6_Spy1666 Serine acetyltransferase K00640 cysE; serine O-acetyltransferase [EC:2.3.1.30] B B 09108 Metabolism of cofactors and vitamins C 00730 Thiamine metabolism [PATH:spa00730] D M6_Spy0647 Cysteine desulfhydrase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D M6_Spy0842 Cysteine desulfhydrase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D M6_Spy0648 Thiamine biosynthesis protein K03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4] D M6_Spy0255 GTPase K06949 rsgA; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100] D M6_Spy0257 Thiamin pyrophosphokinase K00949 thiN; thiamine pyrophosphokinase [EC:2.7.6.2] D M6_Spy0114 Adenylate kinase K00939 adk; adenylate kinase [EC:2.7.4.3] C 00740 Riboflavin metabolism [PATH:spa00740] D M6_Spy1472 Hydrolase (HAD superfamily) K21064 ycsE; 5-amino-6-(5-phospho-D-ribitylamino)uracil phosphatase [EC:3.1.3.104] D M6_Spy0950 Riboflavin kinase K11753 ribF; riboflavin kinase / FMN adenylyltransferase [EC:2.7.1.26 2.7.7.2] D M6_Spy0834 Class B acid phosphatase K03788 aphA; acid phosphatase (class B) [EC:3.1.3.2] D M6_Spy0387 Phosphohydrolase (MutT/nudix family protein) K01515 nudF; ADP-ribose diphosphatase [EC:3.6.1.13 3.6.1.-] C 00750 Vitamin B6 metabolism [PATH:spa00750] D M6_Spy0912 Pyridoxine kinase K00868 pdxK; pyridoxine kinase [EC:2.7.1.35] D M6_Spy1624 phosphomethylpyrimidine kinase K00868 pdxK; pyridoxine kinase [EC:2.7.1.35] C 00760 Nicotinate and nicotinamide metabolism [PATH:spa00760] D M6_Spy1061 Nicotinate-nucleotide pyrophosphorylase [carboxylating] K00767 nadC; nicotinate-nucleotide pyrophosphorylase (carboxylating) [EC:2.4.2.19] D M6_Spy1404 Nicotinate phosphoribosyltransferase K00763 pncB; nicotinate phosphoribosyltransferase [EC:6.3.4.21] D M6_Spy0715 Purine nucleoside phosphorylase K03783 punA; purine-nucleoside phosphorylase [EC:2.4.2.1] D M6_Spy0716 Purine nucleoside phosphorylase K03784 deoD; purine-nucleoside phosphorylase [EC:2.4.2.1] D M6_Spy0695 5'-nucleotidase K01081 E3.1.3.5; 5'-nucleotidase [EC:3.1.3.5] D M6_Spy0291 Nicotinate-nucleotide adenylyltransferase K00969 nadD; nicotinate-nucleotide adenylyltransferase [EC:2.7.7.18] D M6_Spy1403 NH(3)-dependent NAD(+) synthetase K01916 nadE; NAD+ synthase [EC:6.3.1.5] D M6_Spy0186 NAD glycohydrolase K18153 nga; NAD+ glycohydrolase [EC:3.2.2.5] D M6_Spy0846 ATP-NAD kinase K00858 ppnK; NAD+ kinase [EC:2.7.1.23] D M6_Spy0807 Succinate-semialdehyde dehydrogenase [NADP+] K00135 gabD; succinate-semialdehyde dehydrogenase / glutarate-semialdehyde dehydrogenase [EC:1.2.1.16 1.2.1.79 1.2.1.20] C 00770 Pantothenate and CoA biosynthesis [PATH:spa00770] D M6_Spy0678 2-dehydropantoate 2-reductase K00077 panE; 2-dehydropantoate 2-reductase [EC:1.1.1.169] D M6_Spy0934 Pantothenate kinase K00867 coaA; type I pantothenate kinase [EC:2.7.1.33] D M6_Spy0924 phosphopantothenate--cysteine ligase K21977 coaB; phosphopantothenate---cysteine ligase (CTP) [EC:6.3.2.5] D M6_Spy0925 phosphopantothenoylcysteine decarboxylase K01598 PPCDC; phosphopantothenoylcysteine decarboxylase [EC:4.1.1.36] D M6_Spy1288 Phosphopantetheine adenylyltransferase K00954 E2.7.7.3A; pantetheine-phosphate adenylyltransferase [EC:2.7.7.3] D M6_Spy0435 Dephospho-CoA kinase K00859 coaE; dephospho-CoA kinase [EC:2.7.1.24] D M6_Spy1525 Holo-[acyl-carrier protein] synthase K00997 acpS; holo-[acyl-carrier protein] synthase [EC:2.7.8.7] D M6_Spy0730 Branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] C 00780 Biotin metabolism [PATH:spa00780] D M6_Spy1483 3-oxoacyl-[acyl-carrier-protein] synthase K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179] D M6_Spy0383 Short chain dehydrogenase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D M6_Spy1484 3-oxoacyl-[acyl-carrier protein] reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D M6_Spy1481 (3R)-hydroxyacyl-[acyl carrier protein] dehydratase K02372 fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59] D M6_Spy1084 Biotin operon repressor K03524 birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15] C 00785 Lipoic acid metabolism [PATH:spa00785] D M6_Spy0917 Lipoate-protein ligase A K03800 lplA; lipoate---protein ligase [EC:6.3.1.20] D M6_Spy0783 Lipoate-protein ligase A K03800 lplA; lipoate---protein ligase [EC:6.3.1.20] D M6_Spy0779 Dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D M6_Spy0776 Pyruvate dehydrogenase E1 component alpha subunit K00161 PDHA; pyruvate dehydrogenase E1 component subunit alpha [EC:1.2.4.1] D M6_Spy0777 Pyruvate dehydrogenase E1 component beta subunit K00162 PDHB; pyruvate dehydrogenase E1 component subunit beta [EC:1.2.4.1] D M6_Spy0778 Dihydrolipoamide acetyltransferase K00627 DLAT; pyruvate dehydrogenase E2 component (dihydrolipoyllysine-residue acetyltransferase) [EC:2.3.1.12] C 00790 Folate biosynthesis [PATH:spa00790] D M6_Spy0819 GTP cyclohydrolase I K01495 GCH1; GTP cyclohydrolase IA [EC:3.5.4.16] D M6_Spy0821 Dihydroneopterin aldolase K01633 folB; 7,8-dihydroneopterin aldolase/epimerase/oxygenase [EC:4.1.2.25 5.1.99.8 1.13.11.81] D M6_Spy0822 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine pyrophosphokinase K00950 folK; 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine diphosphokinase [EC:2.7.6.3] D M6_Spy0820 Dihydropteroate synthase K00796 folP; dihydropteroate synthase [EC:2.5.1.15] D M6_Spy0706 Dihydrofolate reductase K00287 DHFR; dihydrofolate reductase [EC:1.5.1.3] D M6_Spy0645 folypolyglutamate synthase K11754 folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17] D M6_Spy0818 folypolyglutamate synhtase K11754 folC; dihydrofolate synthase / folylpolyglutamate synthase [EC:6.3.2.12 6.3.2.17] D M6_Spy1703 Para-aminobenzoate synthetase component I K03342 pabBC; para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase [EC:2.6.1.85 4.1.3.38] C 00670 One carbon pool by folate [PATH:spa00670] D M6_Spy0706 Dihydrofolate reductase K00287 DHFR; dihydrofolate reductase [EC:1.5.1.3] D M6_Spy0916 Formate--tetrahydrofolate ligase K01938 fhs; formate--tetrahydrofolate ligase [EC:6.3.4.3] D M6_Spy1771 Formate--tetrahydrofolate ligase K01938 fhs; formate--tetrahydrofolate ligase [EC:6.3.4.3] D M6_Spy1254 Methylenetetrahydrofolate dehydrogenase (NADP+) K01491 folD; methylenetetrahydrofolate dehydrogenase (NADP+) / methenyltetrahydrofolate cyclohydrolase [EC:1.5.1.5 3.5.4.9] D M6_Spy1770 formiminotetrahydrofolate cyclodeaminase K01500 fchA; methenyltetrahydrofolate cyclohydrolase [EC:3.5.4.9] D M6_Spy0863 Serine hydroxymethyltransferase K00600 glyA; glycine hydroxymethyltransferase [EC:2.1.2.1] D M6_Spy0075 Phosphoribosylglycinamide formyltransferase K11175 purN; phosphoribosylglycinamide formyltransferase 1 [EC:2.1.2.2] D M6_Spy0076 phosphoribosylaminoimidazolecarboxamide formyltransferase K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10] D M6_Spy1769 glutamate formiminotransferase K00603 fctD; glutamate formiminotransferase / 5-formyltetrahydrofolate cyclo-ligase [EC:2.1.2.5 6.3.3.2] D M6_Spy1384 Methionyl-tRNA formyltransferase K00604 MTFMT; methionyl-tRNA formyltransferase [EC:2.1.2.9] D M6_Spy0705 Thymidylate synthase K00560 thyA; thymidylate synthase [EC:2.1.1.45] C 00830 Retinol metabolism C 00860 Porphyrin metabolism C 00130 Ubiquinone and other terpenoid-quinone biosynthesis B B 09109 Metabolism of terpenoids and polyketides C 00900 Terpenoid backbone biosynthesis [PATH:spa00900] D M6_Spy0166 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy1390 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy0466 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy0704 Hydroxymethylglutaryl-CoA synthase K01641 HMGCS; hydroxymethylglutaryl-CoA synthase [EC:2.3.3.10] D M6_Spy0703 3-hydroxy-3-methylglutaryl-coenzyme A reductase K00054 mvaA; hydroxymethylglutaryl-CoA reductase [EC:1.1.1.88] D M6_Spy0699 Mevalonate kinase K00869 MVK; mevalonate kinase [EC:2.7.1.36] D M6_Spy0701 Phosphomevalonate kinase K00938 E2.7.4.2; phosphomevalonate kinase [EC:2.7.4.2] D M6_Spy0700 Diphosphomevalonate decarboxylase K01597 MVD; diphosphomevalonate decarboxylase [EC:4.1.1.33] D M6_Spy0702 Isopentenyl-diphosphate delta-isomerase K01823 idi; isopentenyl-diphosphate Delta-isomerase [EC:5.3.3.2] D M6_Spy1251 Dimethylallyltransferase K13789 GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29] D M6_Spy1684 Undecaprenyl pyrophosphate synthetase K00806 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31] C 00902 Monoterpenoid biosynthesis C 00909 Sesquiterpenoid and triterpenoid biosynthesis C 00904 Diterpenoid biosynthesis C 00906 Carotenoid biosynthesis C 00905 Brassinosteroid biosynthesis C 00981 Insect hormone biosynthesis C 00908 Zeatin biosynthesis C 00903 Limonene degradation C 00907 Pinene, camphor and geraniol degradation C 01052 Type I polyketide structures C 00522 Biosynthesis of 12-, 14- and 16-membered macrolides C 01051 Biosynthesis of ansamycins D M6_Spy1423 Transketolase K00615 E2.2.1.1; transketolase [EC:2.2.1.1] C 01059 Biosynthesis of enediyne antibiotics C 01056 Biosynthesis of type II polyketide backbone C 01057 Biosynthesis of type II polyketide products C 00253 Tetracycline biosynthesis C 00523 Polyketide sugar unit biosynthesis [PATH:spa00523] D M6_Spy0760 Glucose-1-phosphate thymidylyltransferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24] D M6_Spy0762 dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] D M6_Spy0761 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13] D M6_Spy0619 dTDP-4-dehydrorhamnose reductase K00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133] C 01054 Nonribosomal peptide structures C 01053 Biosynthesis of siderophore group nonribosomal peptides C 01055 Biosynthesis of vancomycin group antibiotics D M6_Spy0762 dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] B B 09110 Biosynthesis of other secondary metabolites C 00940 Phenylpropanoid biosynthesis C 00945 Stilbenoid, diarylheptanoid and gingerol biosynthesis C 00941 Flavonoid biosynthesis C 00944 Flavone and flavonol biosynthesis C 00942 Anthocyanin biosynthesis C 00943 Isoflavonoid biosynthesis C 00946 Degradation of flavonoids [PATH:spa00946] D M6_Spy1331 Beta-glucosidase K05350 bglB; beta-glucosidase [EC:3.2.1.21] C 00901 Indole alkaloid biosynthesis C 00403 Indole diterpene alkaloid biosynthesis C 00950 Isoquinoline alkaloid biosynthesis C 00960 Tropane, piperidine and pyridine alkaloid biosynthesis C 00996 Biosynthesis of various alkaloids C 00232 Caffeine metabolism C 00965 Betalain biosynthesis C 00966 Glucosinolate biosynthesis C 00402 Benzoxazinoid biosynthesis C 00311 Penicillin and cephalosporin biosynthesis C 00332 Carbapenem biosynthesis [PATH:spa00332] D M6_Spy1419 Glutamate 5-kinase K00931 proB; glutamate 5-kinase [EC:2.7.2.11] D M6_Spy1418 Gamma-glutamyl phosphate reductase K00147 proA; glutamate-5-semialdehyde dehydrogenase [EC:1.2.1.41] C 00261 Monobactam biosynthesis C 00331 Clavulanic acid biosynthesis C 00521 Streptomycin biosynthesis [PATH:spa00521] D M6_Spy1278 Glucokinase K25026 glk; glucokinase [EC:2.7.1.2] D M6_Spy0927 phosphoglucomutase K01835 pgm; phosphoglucomutase [EC:5.4.2.2] D M6_Spy0947 Myo-inositol-1(or 4)-monophosphatase K01092 E3.1.3.25; myo-inositol-1(or 4)-monophosphatase [EC:3.1.3.25] D M6_Spy0760 Glucose-1-phosphate thymidylyltransferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24] D M6_Spy0762 dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] D M6_Spy0761 dTDP-4-dehydrorhamnose 3,5-epimerase K01790 rfbC; dTDP-4-dehydrorhamnose 3,5-epimerase [EC:5.1.3.13] D M6_Spy0619 dTDP-4-dehydrorhamnose reductase K00067 rfbD; dTDP-4-dehydrorhamnose reductase [EC:1.1.1.133] C 00524 Neomycin, kanamycin and gentamicin biosynthesis D M6_Spy1278 Glucokinase K25026 glk; glucokinase [EC:2.7.1.2] C 00525 Acarbose and validamycin biosynthesis [PATH:spa00525] D M6_Spy0760 Glucose-1-phosphate thymidylyltransferase K00973 rfbA; glucose-1-phosphate thymidylyltransferase [EC:2.7.7.24] D M6_Spy0762 dTDP-glucose 4,6-dehydratase K01710 rfbB; dTDP-glucose 4,6-dehydratase [EC:4.2.1.46] C 00401 Novobiocin biosynthesis C 00404 Staurosporine biosynthesis C 00405 Phenazine biosynthesis D M6_Spy1704 Anthranilate synthase component II K01658 trpG; anthranilate synthase component II [EC:4.1.3.27] C 00333 Prodigiosin biosynthesis D M6_Spy1485 Malonyl-CoA-[acyl-carrier-protein] transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39] D M6_Spy0383 Short chain dehydrogenase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D M6_Spy1484 3-oxoacyl-[acyl-carrier protein] reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] C 00254 Aflatoxin biosynthesis C 00998 Biosynthesis of various antibiotics D M6_Spy1487 Acyl carrier protein K02078 acpP; acyl carrier protein D M6_Spy0070 Acyl carrier protein K02078 acpP; acyl carrier protein C 00999 Biosynthesis of various plant secondary metabolites [PATH:spa00999] D M6_Spy1082 S-adenosylmethionine synthetase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6] D M6_Spy1147 S-adenosylmethionine synthetase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6] D M6_Spy0479 S-adenosylmethionine synthetase K00789 metK; S-adenosylmethionine synthetase [EC:2.5.1.6] D M6_Spy0475 Shikimate 5-dehydrogenase K00014 aroE; shikimate dehydrogenase [EC:1.1.1.25] D M6_Spy1331 Beta-glucosidase K05350 bglB; beta-glucosidase [EC:3.2.1.21] C 00997 Biosynthesis of various other secondary metabolites B B 09111 Xenobiotics biodegradation and metabolism C 00362 Benzoate degradation [PATH:spa00362] D M6_Spy1786 Glyoxalase family protein K07104 catE; catechol 2,3-dioxygenase [EC:1.13.11.2] D M6_Spy0857 4-oxalocrotonate tautomerase K01821 praC; 4-oxalocrotonate tautomerase [EC:5.3.2.6] D M6_Spy0886 Oxaloacetate decarboxylase beta chain K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1] D M6_Spy0892 Oxaloacetate decarboxylase beta chain K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1] D M6_Spy0885 Biotin carboxyl carrier protein of oxaloacetate decarboxylase K23351 gcdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma D M6_Spy0891 Biotin carboxyl carrier protein of oxaloacetate decarboxylase K23351 gcdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma D M6_Spy0166 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy1390 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy0466 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] C 00627 Aminobenzoate degradation [PATH:spa00627] D M6_Spy0722 Amidase family protein K01426 E3.5.1.4; amidase [EC:3.5.1.4] D M6_Spy1702 Amidase family protein K01426 E3.5.1.4; amidase [EC:3.5.1.4] D M6_Spy0324 Acylphosphatase K01512 acyP; acylphosphatase [EC:3.6.1.7] D M6_Spy1391 Acetate CoA-transferase alpha subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] D M6_Spy0167 Acetate CoA-transferase alpha subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] D M6_Spy1392 Acetate CoA-transferase beta subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] D M6_Spy0168 Acetate CoA-transferase beta subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] C 00364 Fluorobenzoate degradation C 00625 Chloroalkane and chloroalkene degradation [PATH:spa00625] D M6_Spy0090 Alcohol dehydrogenase K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1] D M6_Spy0832 Zn-dependent alcohol dehydrogenases and related dehydrogenases K00001 E1.1.1.1; alcohol dehydrogenase [EC:1.1.1.1] D M6_Spy0088 Alcohol dehydrogenase K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1] C 00361 Chlorocyclohexane and chlorobenzene degradation D M6_Spy1786 Glyoxalase family protein K07104 catE; catechol 2,3-dioxygenase [EC:1.13.11.2] C 00623 Toluene degradation C 00622 Xylene degradation [PATH:spa00622] D M6_Spy1786 Glyoxalase family protein K07104 catE; catechol 2,3-dioxygenase [EC:1.13.11.2] D M6_Spy0857 4-oxalocrotonate tautomerase K01821 praC; 4-oxalocrotonate tautomerase [EC:5.3.2.6] C 00633 Nitrotoluene degradation C 00642 Ethylbenzene degradation C 00643 Styrene degradation [PATH:spa00643] D M6_Spy0722 Amidase family protein K01426 E3.5.1.4; amidase [EC:3.5.1.4] D M6_Spy1702 Amidase family protein K01426 E3.5.1.4; amidase [EC:3.5.1.4] D M6_Spy1786 Glyoxalase family protein K07104 catE; catechol 2,3-dioxygenase [EC:1.13.11.2] C 00791 Atrazine degradation C 00930 Caprolactam degradation C 00363 Bisphenol degradation C 00621 Dioxin degradation D M6_Spy0857 4-oxalocrotonate tautomerase K01821 praC; 4-oxalocrotonate tautomerase [EC:5.3.2.6] C 00626 Naphthalene degradation [PATH:spa00626] D M6_Spy0090 Alcohol dehydrogenase K13953 adhP; alcohol dehydrogenase, propanol-preferring [EC:1.1.1.1] D M6_Spy0832 Zn-dependent alcohol dehydrogenases and related dehydrogenases K00001 E1.1.1.1; alcohol dehydrogenase [EC:1.1.1.1] D M6_Spy0088 Alcohol dehydrogenase K04072 adhE; acetaldehyde dehydrogenase / alcohol dehydrogenase [EC:1.2.1.10 1.1.1.1] C 00624 Polycyclic aromatic hydrocarbon degradation C 00365 Furfural degradation C 00984 Steroid degradation C 00980 Metabolism of xenobiotics by cytochrome P450 C 00982 Drug metabolism - cytochrome P450 C 00983 Drug metabolism - other enzymes B B 09112 Not included in regular maps C 09113 Global maps only # A09120 Genetic Information Processing B B 09121 Transcription C 03020 RNA polymerase [PATH:spa03020] D M6_Spy0131 DNA-directed RNA polymerase beta chain K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6] D M6_Spy0132 DNA-directed RNA polymerase beta' chain K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6] D M6_Spy0119 DNA-directed RNA polymerase alpha chain K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6] D M6_Spy1386 DNA-directed RNA polymerase omega chain K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6] D M6_Spy1619 DNA-directed RNA polymerase delta chain K03048 rpoE; DNA-directed RNA polymerase subunit delta C 03022 Basal transcription factors C 03040 Spliceosome B B 09122 Translation C 03010 Ribosome [PATH:spa03010] D M6_Spy0732 SSU ribosomal protein S1P K02945 RP-S1; small subunit ribosomal protein S1 D M6_Spy1779 SSU ribosomal protein S2P K02967 RP-S2; small subunit ribosomal protein S2 D M6_Spy0099 SSU ribosomal protein S3P K02982 RP-S3; small subunit ribosomal protein S3 D M6_Spy1851 SSU ribosomal protein S4P K02986 RP-S4; small subunit ribosomal protein S4 D M6_Spy0110 SSU ribosomal protein S5P K02988 RP-S5; small subunit ribosomal protein S5 D M6_Spy1567 SSU ribosomal protein S6P K02990 RP-S6; small subunit ribosomal protein S6 D M6_Spy0263 SSU ribosomal protein S7P K02992 RP-S7; small subunit ribosomal protein S7 D M6_Spy0107 SSU ribosomal protein S8P K02994 RP-S8; small subunit ribosomal protein S8 D M6_Spy1654 SSU ribosomal protein S9P K02996 RP-S9; small subunit ribosomal protein S9 D M6_Spy0092 SSU ribosomal protein S10P K02946 RP-S10; small subunit ribosomal protein S10 D M6_Spy0118 SSU ribosomal protein S11P K02948 RP-S11; small subunit ribosomal protein S11 D M6_Spy0262 SSU ribosomal protein S12P K02950 RP-S12; small subunit ribosomal protein S12 D M6_Spy0117 SSU ribosomal protein S13P K02952 RP-S13; small subunit ribosomal protein S13 D M6_Spy0106 SSU ribosomal protein S14P K02954 RP-S14; small subunit ribosomal protein S14 D M6_Spy1601 SSU ribosomal protein S14P K02954 RP-S14; small subunit ribosomal protein S14 D M6_Spy1674 SSU ribosomal protein S15P K02956 RP-S15; small subunit ribosomal protein S15 D M6_Spy0667 SSU ribosomal protein S16P K02959 RP-S16; small subunit ribosomal protein S16 D M6_Spy0102 SSU ribosomal protein S17P K02961 RP-S17; small subunit ribosomal protein S17 D M6_Spy1565 SSU ribosomal protein S18P K02963 RP-S18; small subunit ribosomal protein S18 D M6_Spy0097 SSU ribosomal protein S19P K02965 RP-S19; small subunit ribosomal protein S19 D M6_Spy0935 SSU ribosomal protein S20P K02968 RP-S20; small subunit ribosomal protein S20 D M6_Spy0614 SSU ribosomal protein S21P K02970 RP-S21; small subunit ribosomal protein S21 D M6_Spy0402 LSU ribosomal protein L1P K02863 RP-L1; large subunit ribosomal protein L1 D M6_Spy0096 LSU ribosomal protein L2P K02886 RP-L2; large subunit ribosomal protein L2 D M6_Spy0093 LSU ribosomal protein L3P K02906 RP-L3; large subunit ribosomal protein L3 D M6_Spy0094 LSU ribosomal protein L1E K02926 RP-L4; large subunit ribosomal protein L4 D M6_Spy0105 LSU ribosomal protein L5P K02931 RP-L5; large subunit ribosomal protein L5 D M6_Spy0108 LSU ribosomal protein L6P K02933 RP-L6; large subunit ribosomal protein L6 D M6_Spy0814 LSU ribosomal protein L12P (L7/L12) K02935 RP-L7; large subunit ribosomal protein L7/L12 D M6_Spy1854 LSU ribosomal protein L9P K02939 RP-L9; large subunit ribosomal protein L9 D M6_Spy0813 LSU ribosomal protein L10P K02864 RP-L10; large subunit ribosomal protein L10 D M6_Spy0401 LSU ribosomal protein L11P K02867 RP-L11; large subunit ribosomal protein L11 D M6_Spy1655 LSU ribosomal protein L13P K02871 RP-L13; large subunit ribosomal protein L13 D M6_Spy0103 LSU ribosomal protein L14P K02874 RP-L14; large subunit ribosomal protein L14 D M6_Spy0112 LSU ribosomal protein L15P K02876 RP-L15; large subunit ribosomal protein L15 D M6_Spy0100 LSU ribosomal protein L16P K02878 RP-L16; large subunit ribosomal protein L16 D M6_Spy0120 LSU ribosomal protein L17P K02879 RP-L17; large subunit ribosomal protein L17 D M6_Spy0109 LSU ribosomal protein L18P K02881 RP-L18; large subunit ribosomal protein L18 D M6_Spy0571 LSU ribosomal protein L19P K02884 RP-L19; large subunit ribosomal protein L19 D M6_Spy0638 LSU ribosomal protein L20P K02887 RP-L20; large subunit ribosomal protein L20 D M6_Spy0651 LSU ribosomal protein L21P K02888 RP-L21; large subunit ribosomal protein L21 D M6_Spy0098 LSU ribosomal protein L22P K02890 RP-L22; large subunit ribosomal protein L22 D M6_Spy0095 LSU ribosomal protein L23P K02892 RP-L23; large subunit ribosomal protein L23 D M6_Spy0104 LSU ribosomal protein L24P K02895 RP-L24; large subunit ribosomal protein L24 D M6_Spy0653 LSU ribosomal protein L27P K02899 RP-L27; large subunit ribosomal protein L27 D M6_Spy1615 LSU ribosomal protein L28P K02902 RP-L28; large subunit ribosomal protein L28 D M6_Spy0101 LSU ribosomal protein L29P K02904 RP-L29; large subunit ribosomal protein L29 D M6_Spy0111 LSU ribosomal protein L30P K02907 RP-L30; large subunit ribosomal protein L30 D M6_Spy0566 LSU ribosomal protein L31P K02909 RP-L31; large subunit ribosomal protein L31 D M6_Spy1834 LSU ribosomal protein L32P K02911 RP-L32; large subunit ribosomal protein L32 D M6_Spy0439 LSU ribosomal protein L33P K02913 RP-L33; large subunit ribosomal protein L33 D M6_Spy1752 LSU ribosomal protein L33P K02913 RP-L33; large subunit ribosomal protein L33 D M6_Spy1835 LSU ribosomal protein L33P K02913 RP-L33; large subunit ribosomal protein L33 D M6_Spy0242 LSU ribosomal protein L34P K02914 RP-L34; large subunit ribosomal protein L34 D M6_Spy0637 LSU ribosomal protein L35P K02916 RP-L35; large subunit ribosomal protein L35 D M6_Spy0116 LSU ribosomal protein L36P K02919 RP-L36; large subunit ribosomal protein L36 D M6_Spys1887 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D M6_Spys1900 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D M6_Spys1921 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D M6_Spys1937 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D M6_Spys1958 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D M6_Spys1966 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D M6_Spys1889 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D M6_Spys1902 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D M6_Spys1923 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D M6_Spys1939 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D M6_Spys1956 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D M6_Spys1964 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D M6_Spys1890 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D M6_Spys1903 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D M6_Spys1924 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D M6_Spys1940 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D M6_Spys1955 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D M6_Spys1963 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA C 00970 Aminoacyl-tRNA biosynthesis [PATH:spa00970] D M6_Spys1888 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D M6_Spys1965 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D M6_Spys1938 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D M6_Spys1901 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D M6_Spys1957 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D M6_Spys1922 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D M6_Spys1946 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D M6_Spys1971 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D M6_Spys1943 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D M6_Spys1898 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D M6_Spys1911 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D M6_Spys1961 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D M6_Spys1942 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D M6_Spys1969 tRNA-Asn K14220 tRNA-Asn; tRNA Asn D M6_Spys1941 tRNA-Asn K14220 tRNA-Asn; tRNA Asn D M6_Spys1962 tRNA-Asn K14220 tRNA-Asn; tRNA Asn D M6_Spys1892 tRNA-Asp K14221 tRNA-Asp; tRNA Asp D M6_Spys1953 tRNA-Asp K14221 tRNA-Asp; tRNA Asp D M6_Spys1905 tRNA-Asp K14221 tRNA-Asp; tRNA Asp D M6_Spys1968 tRNA-Cys K14222 tRNA-Cys; tRNA Cys D M6_Spys1945 tRNA-Gln K14223 tRNA-Gln; tRNA Gln D M6_Spys1935 tRNA-Gln K14223 tRNA-Gln; tRNA Gln D M6_Spys1928 tRNA-Glu K14224 tRNA-Glu; tRNA Glu D M6_Spys1948 tRNA-Glu K14224 tRNA-Glu; tRNA Glu D M6_Spys1970 tRNA-Glu K14224 tRNA-Glu; tRNA Glu D M6_Spys1918 tRNA-Gly K14225 tRNA-Gly; tRNA Gly D M6_Spys1926 tRNA-Gly K14225 tRNA-Gly; tRNA Gly D M6_Spys1896 tRNA-Gly K14225 tRNA-Gly; tRNA Gly D M6_Spys1909 tRNA-Gly K14225 tRNA-Gly; tRNA Gly D M6_Spys1934 tRNA-His K14226 tRNA-His; tRNA His D M6_Spys1919 tRNA-Ile K14227 tRNA-Ile; tRNA Ile D M6_Spys1927 tRNA-Ile K14227 tRNA-Ile; tRNA Ile D M6_Spys1949 tRNA-Ile K14227 tRNA-Ile; tRNA Ile D M6_Spys1897 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D M6_Spys1910 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D M6_Spys1936 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D M6_Spys1894 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D M6_Spys1907 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D M6_Spys1951 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D M6_Spys1960 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D M6_Spys1893 tRNA-Lys K14229 tRNA-Lys; tRNA Lys D M6_Spys1952 tRNA-Lys K14229 tRNA-Lys; tRNA Lys D M6_Spys1906 tRNA-Lys K14229 tRNA-Lys; tRNA Lys D M6_Spys1967 tRNA-Lys K14229 tRNA-Lys; tRNA Lys D M6_Spys1913 tRNA-Met K14230 tRNA-Met; tRNA Met D M6_Spys1914 tRNA-Met K14230 tRNA-Met; tRNA Met D M6_Spys1916 tRNA-Met K14230 tRNA-Met; tRNA Met D M6_Spys1930 tRNA-Met K14230 tRNA-Met; tRNA Met D M6_Spys1917 tRNA-Phe K14231 tRNA-Phe; tRNA Phe D M6_Spys1931 tRNA-Phe K14231 tRNA-Phe; tRNA Phe D M6_Spys1899 tRNA-Pro K14232 tRNA-Pro; tRNA Pro D M6_Spys1912 tRNA-Pro K14232 tRNA-Pro; tRNA Pro D M6_Spys1915 pseudogene K14233 tRNA-Ser; tRNA Ser D M6_Spys1929 pseudogene K14233 tRNA-Ser; tRNA Ser D M6_Spys1959 tRNA-Ser K14233 tRNA-Ser; tRNA Ser D M6_Spys1920 tRNA-Ser K14233 tRNA-Ser; tRNA Ser D M6_Spys1947 tRNA-Thr K14234 tRNA-Thr; tRNA Thr D M6_Spys1895 tRNA-Thr K14234 tRNA-Thr; tRNA Thr D M6_Spys1908 tRNA-Thr K14234 tRNA-Thr; tRNA Thr D M6_Spys1950 tRNA-Thr K14234 tRNA-Thr; tRNA Thr D M6_Spys1933 tRNA-Trp K14235 tRNA-Trp; tRNA Trp D M6_Spys1932 tRNA-Tyr K14236 tRNA-Tyr; tRNA Tyr D M6_Spys1944 tRNA-Tyr K14236 tRNA-Tyr; tRNA Tyr D M6_Spys1891 tRNA-Val K14237 tRNA-Val; tRNA Val D M6_Spys1925 tRNA-Val K14237 tRNA-Val; tRNA Val D M6_Spys1904 tRNA-Val K14237 tRNA-Val; tRNA Val D M6_Spys1954 tRNA-Val K14237 tRNA-Val; tRNA Val D M6_Spy0234 Glutamyl-tRNA synthetase K09698 gltX; nondiscriminating glutamyl-tRNA synthetase [EC:6.1.1.24] D M6_Spy1501 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit A K02433 gatA; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7] D M6_Spy1500 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B K02434 gatB; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7] D M6_Spy1502 Glutamyl-tRNA(Gln) amidotransferase subunit C K02435 gatC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7] D M6_Spy1107 Alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7] D M6_Spy1832 Aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12] D M6_Spy0558 Asparaginyl-tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22] D M6_Spy1433 Glycyl-tRNA synthetase alpha chain K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14] D M6_Spy1432 Glycyl-tRNA synthetase beta chain K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14] D M6_Spy0454 Threonyl-tRNA synthetase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3] D M6_Spy1477 Seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11] D M6_Spy1663 Cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16] D M6_Spy0370 Methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10] D M6_Spy1384 Methionyl-tRNA formyltransferase K00604 MTFMT; methionyl-tRNA formyltransferase [EC:2.1.2.9] D M6_Spy1310 Valyl-tRNA synthetase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9] D M6_Spy0193 Leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4] D M6_Spy1264 Isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5] D M6_Spy0516 Lysyl-tRNA synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6] D M6_Spy1827 Arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19] D M6_Spy1681 Prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15] D M6_Spy1833 Histidyl-tRNA synthetase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21] D M6_Spy0604 Phenylalanyl-tRNA synthetase alpha chain K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20] D M6_Spy0605 Phenylalanyl-tRNA synthetase beta chain K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20] D M6_Spy0129 Tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1] D M6_Spy1876 Tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2] C 03013 Nucleocytoplasmic transport C 03015 mRNA surveillance pathway C 03008 Ribosome biogenesis in eukaryotes B B 09123 Folding, sorting and degradation C 03060 Protein export [PATH:spa03060] D M6_Spy0113 Protein translocase subunit secY K03076 secY; preprotein translocase subunit SecY D M6_Spy1751 Protein translocase subunit secE K03073 secE; preprotein translocase subunit SecE D M6_Spy0440 Protein translocase subunit secG K03075 secG; preprotein translocase subunit SecG D M6_Spy1685 Protein translocase subunit K03210 yajC; preprotein translocase subunit YajC D M6_Spy0239 60 kDa inner membrane protein YIDC K03217 yidC; YidC/Oxa1 family membrane protein insertase D M6_Spy0323 60 kDa inner membrane protein K03217 yidC; YidC/Oxa1 family membrane protein insertase D M6_Spy1526 SecA K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8] D M6_Spy0904 signal recognition particle subunit FFH K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4] D M6_Spy0496 Cell division protein ftsY K03110 ftsY; fused signal recognition particle receptor D M6_Spy1577 Signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89] D M6_Spy0974 Signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89] D M6_Spy0655 Lipoprotein signal peptidase K03101 lspA; signal peptidase II [EC:3.4.23.36] C 04141 Protein processing in endoplasmic reticulum C 04130 SNARE interactions in vesicular transport C 04120 Ubiquitin mediated proteolysis C 04122 Sulfur relay system [PATH:spa04122] D M6_Spy0647 Cysteine desulfhydrase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D M6_Spy0842 Cysteine desulfhydrase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D M6_Spy1857 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase K00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13] D M6_Spy0648 Thiamine biosynthesis protein K03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4] C 03050 Proteasome C 03018 RNA degradation [PATH:spa03018] D M6_Spy0577 Enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] D M6_Spy1668 Polyribonucleotide nucleotidyltransferase K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8] D M6_Spy0441 Exoribonuclease II K12573 rnr; ribonuclease R [EC:3.1.13.1] D M6_Spy1180 ATP-dependent RNA helicase K05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7] D M6_Spy1388 Hydrolase (HAD superfamily) K18682 rny; ribonucrease Y [EC:3.1.-.-] D M6_Spy1606 Zn-dependent hydrolase K12574 rnj; ribonuclease J [EC:3.1.-.-] D M6_Spy0772 Zn-dependent hydrolase K12574 rnj; ribonuclease J [EC:3.1.-.-] D M6_Spy0976 Non-allosteric 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D M6_Spy1492 DnaK K04043 dnaK; molecular chaperone DnaK D M6_Spy1760 60 kDa chaperonin GROEL K04077 groEL; chaperonin GroEL [EC:5.6.1.7] B B 09124 Replication and repair C 03030 DNA replication [PATH:spa03030] D M6_Spy1594 DNA polymerase III, epsilon chain K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D M6_Spy0977 DNA polymerase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] D M6_Spy1680 DNA polymerase III alpha subunit K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7] D M6_Spy1086 DNA polymerase III subunit gamma/tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] D M6_Spy0357 DNA polymerase III, delta' subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7] D M6_Spy1121 DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] D M6_Spy0002 DNA polymerase III beta chain K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] D M6_Spy1853 Replicative DNA helicase K02314 dnaB; replicative DNA helicase [EC:5.6.2.3] D M6_Spy0616 DNA primase K02316 dnaG; DNA primase [EC:2.7.7.101] D M6_Spy1566 Phage single-strand DNA binding protein K03111 ssb; single-strand DNA-binding protein D M6_Spy0151 Single-strand DNA binding protein K03111 ssb; single-strand DNA-binding protein D M6_Spy0879 Ribonuclease HII K03470 rnhB; ribonuclease HII [EC:3.1.26.4] D M6_Spy1576 Ribonuclease HIII K03471 rnhC; ribonuclease HIII [EC:3.1.26.4] D M6_Spy0205 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7] D M6_Spy0590 NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] C 03410 Base excision repair [PATH:spa03410] D M6_Spy0756 Endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] D M6_Spy0725 Uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27] D M6_Spy1569 A/G-specific adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] D M6_Spy0434 Formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18] D M6_Spy1800 DNA-3-methyladenine glycosylase K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20] D M6_Spy0365 Exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2] D M6_Spy0205 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7] D M6_Spy0753 RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] D M6_Spy0590 NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] C 03420 Nucleotide excision repair [PATH:spa03420] D M6_Spy0006 Transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4] D M6_Spy1539 Excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A D M6_Spy1044 Excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B D M6_Spy0808 Excinuclease ABC subunit C K03703 uvrC; excinuclease ABC subunit C D M6_Spy0966 DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4] D M6_Spy0205 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7] D M6_Spy0590 NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] C 03430 Mismatch repair [PATH:spa03430] D M6_Spy1825 MutS K03555 mutS; DNA mismatch repair protein MutS D M6_Spy1573 MutS K07456 mutS2; DNA mismatch repair protein MutS2 D M6_Spy1803 MutL K03572 mutL; DNA mismatch repair protein MutL D M6_Spy0966 DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4] D M6_Spy1253 Exodeoxyribonuclease VII large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6] D M6_Spy1252 Exodeoxyribonuclease VII small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6] D M6_Spy0753 RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] D M6_Spy1566 Phage single-strand DNA binding protein K03111 ssb; single-strand DNA-binding protein D M6_Spy0151 Single-strand DNA binding protein K03111 ssb; single-strand DNA-binding protein D M6_Spy0977 DNA polymerase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] D M6_Spy1680 DNA polymerase III alpha subunit K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7] D M6_Spy0002 DNA polymerase III beta chain K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] D M6_Spy1086 DNA polymerase III subunit gamma/tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] D M6_Spy1121 DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] D M6_Spy0357 DNA polymerase III, delta' subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7] D M6_Spy1594 DNA polymerase III, epsilon chain K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D M6_Spy0590 NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] C 03440 Homologous recombination [PATH:spa03440] D M6_Spy0753 RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] D M6_Spy1566 Phage single-strand DNA binding protein K03111 ssb; single-strand DNA-binding protein D M6_Spy0151 Single-strand DNA binding protein K03111 ssb; single-strand DNA-binding protein D M6_Spy1873 RecF K03629 recF; DNA replication and repair protein RecF D M6_Spy0019 RecO K03584 recO; DNA repair protein RecO (recombination protein O) D M6_Spy1186 RecR K06187 recR; recombination protein RecR D M6_Spy1798 RecA K03553 recA; recombination protein RecA D M6_Spy0205 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7] D M6_Spy1801 Holliday junction DNA helicase K03550 ruvA; holliday junction DNA helicase RuvA D M6_Spy0084 Holliday junction DNA helicase K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4] D M6_Spy1512 ATP-dependent DNA helicase K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4] D M6_Spy1578 Exodeoxyribonuclease V alpha chain K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5] D M6_Spy0977 DNA polymerase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] D M6_Spy1680 DNA polymerase III alpha subunit K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7] D M6_Spy0002 DNA polymerase III beta chain K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] D M6_Spy1086 DNA polymerase III subunit gamma/tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] D M6_Spy1121 DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] D M6_Spy0357 DNA polymerase III, delta' subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7] D M6_Spy1594 DNA polymerase III, epsilon chain K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D M6_Spy1385 Primosomal protein N' K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4] C 03450 Non-homologous end-joining C 03460 Fanconi anemia pathway B B 09126 Chromosome C 03082 ATP-dependent chromatin remodeling C 03083 Polycomb repressive complex B B 09125 Information processing in viruses C 03230 Viral genome structure C 03240 Viral replication C 03250 Viral life cycle - HIV-1 [PATH:spa03250] D M6_Spy0395 Peptidyl-prolyl cis-trans isomerase K03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8] C 03260 Virion - Human immunodeficiency virus C 03271 Virion - Rotavirus C 03262 Virion - Coronavirus C 03261 Virion - Influenza virus C 03263 Virion - Enterovirus C 03264 Virion - Flavivirus C 03265 Virion - Ebolavirus and Lyssavirus C 03266 Virion - Herpesvirus C 03268 Virion - Orthopoxvirus C 03267 Virion - Adenovirus C 03259 Virion - Bacteriophages T4 and T7 C 03258 Virion - Bacteriophage lambda # A09130 Environmental Information Processing B B 09131 Membrane transport C 02010 ABC transporters [PATH:spa02010] D M6_Spy0806 Iron(III)-binding protein K02012 afuA; iron(III) transport system substrate-binding protein D M6_Spy0827 Spermidine/putrescine-binding protein K11069 potD; spermidine/putrescine transport system substrate-binding protein D M6_Spy0826 PotC K11070 potC; spermidine/putrescine transport system permease protein D M6_Spy0825 PotB K11071 potB; spermidine/putrescine transport system permease protein D M6_Spy0824 PotA K11072 potA; spermidine/putrescine transport system ATP-binding protein [EC:7.6.2.11] D M6_Spy0204 Glycine betaine-binding protein K02001 proW; glycine betaine/proline transport system permease protein D M6_Spy0203 Glycine betaine transport ATP-binding protein K02000 proV; glycine betaine/proline transport system ATP-binding protein [EC:7.6.2.9] D M6_Spy0852 Glycine betaine transport system permease protein K05845 opuC; osmoprotectant transport system substrate-binding protein D M6_Spy0851 Glycine betaine transport ATP-binding protein K05847 opuA; osmoprotectant transport system ATP-binding protein [EC:7.6.2.9] D M6_Spy1690 Multiple sugar transport ATP-binding protein K10112 msmX; multiple sugar transport system ATP-binding protein [EC:7.5.2.-] D M6_Spy1032 Maltose/maltodextrin-binding protein K15770 cycB; arabinogalactan oligomer / maltooligosaccharide transport system substrate-binding protein D M6_Spy1033 MalF K15771 ganP; arabinogalactan oligomer / maltooligosaccharide transport system permease protein D M6_Spy1034 MalG K15772 ganQ; arabinogalactan oligomer / maltooligosaccharide transport system permease protein D M6_Spy1326 Sugar-binding protein K17318 lplA; putative aldouronate transport system substrate-binding protein D M6_Spy1328 Sugar transport system permease protein K17319 lplB; putative aldouronate transport system permease protein D M6_Spy1327 Sugar transport system permease protein K17320 lplC; putative aldouronate transport system permease protein D M6_Spy0931 Nucleoside-binding protein K07335 bmpA; basic membrane protein A and related proteins D M6_Spy0184 Nucleoside-binding protein K07335 bmpA; basic membrane protein A and related proteins D M6_Spy0929 Nucleoside transport system permease protein K23535 nupB; general nucleoside transport system permease protein D M6_Spy0928 Nucleoside transport system permease protein K23536 nupC; general nucleoside transport system permease protein D M6_Spy0930 Nucleoside transport ATP-binding protein K23537 nupA; general nucleoside transport system ATP-binding protein D M6_Spy0945 Phosphate-binding protein K02040 pstS; phosphate transport system substrate-binding protein D M6_Spy0944 Phosphate transport system permease protein pstC K02037 pstC; phosphate transport system permease protein D M6_Spy0943 Phosphate transport system permease protein pstA K02038 pstA; phosphate transport system permease protein D M6_Spy0941 Phosphate transport ATP-binding protein pstB K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1] D M6_Spy0942 Phosphate transport ATP-binding protein pstB K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1] D M6_Spy1045 Glutamine-binding protein K10036 glnH; glutamine transport system substrate-binding protein D M6_Spy1046 Glutamine transport ATP-binding protein K10038 glnQ; glutamine transport system ATP-binding protein [EC:7.4.2.1] D M6_Spy0723 Cystine-binding protein K02424 tcyA; L-cystine transport system substrate-binding protein D M6_Spy0298 ABC transporter substrate-binding protein K02424 tcyA; L-cystine transport system substrate-binding protein D M6_Spy0724 Cystine transport system permease protein K10009 tcyB; L-cystine transport system permease protein D M6_Spy1409 Amino acid ABC transporter permease protein K10009 tcyB; L-cystine transport system permease protein D M6_Spy1408 Amino acid transport ATP-binding protein K10010 tcyC; L-cystine transport system ATP-binding protein [EC:7.4.2.1] D M6_Spy0613 Arginine-binding protein K23059 artP; arginine/lysine/histidine transporter system substrate-binding protein D M6_Spy1259 Arginine transport system permease protein K17077 artQ; arginine/lysine/histidine transport system permease protein D M6_Spy1258 Amino acid transport ATP-binding protein K23060 artR; arginine/lysine/histidine transport system ATP-binding protein [EC:7.4.2.1] D M6_Spy0268 ABC transporter amino acid-binding protein K17073 lysX1; putative lysine transport system substrate-binding protein D M6_Spy0267 Amino acid transport ATP-binding protein K17076 lysY; putative lysine transport system ATP-binding protein D M6_Spy0299 ABC transporter substrate-binding protein K02073 metQ; D-methionine transport system substrate-binding protein D M6_Spy0301 ABC transporter permease protein K02072 metI; D-methionine transport system permease protein D M6_Spy0300 ABC transporter ATP-binding protein K02071 metN; D-methionine transport system ATP-binding protein D M6_Spy0280 OppA K15580 oppA; oligopeptide transport system substrate-binding protein D M6_Spy0281 OppB K15581 oppB; oligopeptide transport system permease protein D M6_Spy0282 OppC K15582 oppC; oligopeptide transport system permease protein D M6_Spy0283 OppD K15583 oppD; oligopeptide transport system ATP-binding protein D M6_Spy0284 OppF K10823 oppF; oligopeptide transport system ATP-binding protein D M6_Spy0563 High-affinity zinc uptake system protein znuA precursor K09815 znuA; zinc transport system substrate-binding protein D M6_Spy1717 laminin binding protein K09815 znuA; zinc transport system substrate-binding protein D M6_Spy0127 High-affinity zinc uptake system membrane protein K09816 znuB; zinc transport system permease protein D M6_Spy0126 High-affinity zinc uptake system ATP-binding protein K09817 znuC; zinc transport system ATP-binding protein [EC:7.2.2.20] D M6_Spy0392 Manganese-binding protein K11704 mtsA; iron/zinc/manganese/copper transport system substrate-binding protein D M6_Spy0394 Manganese transport system membrane protein K11705 mtsC; iron/zinc/manganese/copper transport system permease protein D M6_Spy0393 Manganese transport system ATP-binding protein K11706 mtsB; iron/zinc/manganese/copper transport system ATP-binding protein D M6_Spy0212 BioY K03523 bioY; biotin transport system substrate-specific component D M6_Spy1861 Cobalt transport protein cbiQ K16785 ecfT; energy-coupling factor transport system permease protein D M6_Spy1515 Cobalt transport protein K16785 ecfT; energy-coupling factor transport system permease protein D M6_Spy1863 Cobalt transport ATP-binding protein cbiO K16786 ecfA1; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-] D M6_Spy1862 Cobalt transport ATP-binding protein cbiO K16787 ecfA2; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-] D M6_Spy0553 Cell division protein FtsX K09811 ftsX; cell division transport system permease protein D M6_Spy0552 Cell division ATP-binding protein K09812 ftsE; cell division transport system ATP-binding protein D M6_Spy0227 Multidrug resistance ABC transporter ATP-binding and permease protein K18891 patA; ATP-binding cassette, subfamily B, multidrug efflux pump D M6_Spy0228 Multidrug resistance ABC transporter ATP-binding and permease protein K18892 patB; ATP-binding cassette, subfamily B, multidrug efflux pump D M6_Spy0866 Multidrug resistance ABC transporter ATP-binding and permease protein K18887 efrA; ATP-binding cassette, subfamily B, multidrug efflux pump D M6_Spy0867 Multidrug resistance ABC transporter ATP-binding and permease protein K18888 efrB; ATP-binding cassette, subfamily B, multidrug efflux pump D M6_Spy1165 Macrolide-specific ABC-type efflux carrier K18231 msr; macrolide transport system ATP-binding/permease protein C 02060 Phosphotransferase system (PTS) [PATH:spa02060] D M6_Spy1094 Phosphoenolpyruvate-protein phosphotransferase K08483 ptsI; phosphoenolpyruvate-protein phosphotransferase (PTS system enzyme I) [EC:2.7.3.9] D M6_Spy1095 Phosphocarrier protein HPr K02784 ptsH; phosphocarrier protein HPr D M6_Spy1698 PTS system, glucose-specific IIABC component K20108 malT; maltose PTS system EIICB or EIICBA component [EC:2.7.1.208] D M6_Spy1531 PTS system, sucrose-specific IIABC component K02810 scrA; sucrose PTS system EIIBCA or EIIBC component [EC:2.7.1.211] D M6_Spy0499 PTS system, beta-glucoside-specific IIABC component K02757 bglF; beta-glucoside PTS system EIICBA component [EC:2.7.1.-] D M6_Spy1783 PTS system, trehalose-specific IIBC component K02819 treB; trehalose PTS system EIIBC or EIIBCA component [EC:2.7.1.201] D M6_Spy0971 PTS system, mannitol-specific IIBC component K02800 mtlA; mannitol PTS system EIICBA or EIICB component [EC:2.7.1.197] D M6_Spy1643 PTS system, lactose-specific IIA component K02786 lacF; lactose PTS system EIIA component [EC:2.7.1.207] D M6_Spy1642 PTS system, lactose-specific IIBC component K02788 lacE; lactose PTS system EIICB component [EC:2.7.1.207] D M6_Spy1050 PTS system, cellobiose-specific IIA component K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205] D M6_Spy1746 PTS system, cellobiose-specific IIA component K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205] D M6_Spy1051 PTS system, cellobiose-specific IIB component K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205] D M6_Spy1745 PTS system, cellobiose-specific IIB component K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205] D M6_Spy1048 PTS system, cellobiose-specific IIC component K02761 celB; cellobiose PTS system EIIC component D M6_Spy1744 PTS system, cellobiose-specific IIC component K02761 celB; cellobiose PTS system EIIC component D M6_Spy0800 PTS system, mannose/fructose family IIA component K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191] D M6_Spy1473 PTS system, mannose-specific IIAB component K02794 manX; mannose PTS system EIIAB component [EC:2.7.1.191] D M6_Spy1474 PTS system, mannose-specific IIC component K02795 manY; mannose PTS system EIIC component D M6_Spy0802 PTS system, mannose/fructose family IIC component K02795 manY; mannose PTS system EIIC component D M6_Spy1475 PTS system, mannose-specific IID component K02796 manZ; mannose PTS system EIID component D M6_Spy0803 PTS system, mannose/fructose family IID component K02796 manZ; mannose PTS system EIID component D M6_Spy0801 PTS system, mannose/fructose family IIB component K19507 gfrB; fructoselysine/glucoselysine PTS system EIIB component [EC:2.7.1.-] D M6_Spy0544 PTS system, N-acetylgalactosamine-specific IIA component K02744 agaF; N-acetylgalactosamine PTS system EIIA component [EC:2.7.1.-] D M6_Spy0542 PTS system, N-acetylgalactosamine-specific IIB component K02745 agaV; N-acetylgalactosamine PTS system EIIB component [EC:2.7.1.-] D M6_Spy0541 PTS system, N-acetylgalactosamine-specific IIC component K02746 agaW; N-acetylgalactosamine PTS system EIIC component D M6_Spy0540 PTS system, N-acetylgalactosamine-specific IID component K02747 agaE; N-acetylgalactosamine PTS system EIID component D M6_Spy1450 PTS system, galactose-specific IIA component K20112 gatA; galactose PTS system EIIA component [EC:2.7.1.204] D M6_Spy1449 PTS system, galactose-specific IIB component K20113 gatB; galactose PTS system EIIB component [EC:2.7.1.204] D M6_Spy1448 PTS system, galactose-specific IIC component K20114 gatC; galactose PTS system EIIC component D M6_Spy0196 PTS system, 3-keto-L-gulonate specific IIA component K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194] D M6_Spy1672 Transcription antiterminator, BglG family K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194] D M6_Spy0195 PTS system, 3-keto-L-gulonate specific IIB component K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194] D M6_Spy1671 PTS system IIB component K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194] D M6_Spy1670 Putative transport protein K03475 ulaA; ascorbate PTS system EIIC component D M6_Spy0194 PTS system, 3-keto-L-gulonate specific IIC component K03475 ulaA; ascorbate PTS system EIIC component D M6_Spy0681 PTS system, fructose-specific IIABC component K02770 fruA; fructose PTS system EIIBC or EIIC component [EC:2.7.1.202] D M6_Spy0680 1-phosphofructokinase K00882 fruK; 1-phosphofructokinase [EC:2.7.1.56] C 03070 Bacterial secretion system [PATH:spa03070] D M6_Spy1751 Protein translocase subunit secE K03073 secE; preprotein translocase subunit SecE D M6_Spy0440 Protein translocase subunit secG K03075 secG; preprotein translocase subunit SecG D M6_Spy0113 Protein translocase subunit secY K03076 secY; preprotein translocase subunit SecY D M6_Spy1685 Protein translocase subunit K03210 yajC; preprotein translocase subunit YajC D M6_Spy0239 60 kDa inner membrane protein YIDC K03217 yidC; YidC/Oxa1 family membrane protein insertase D M6_Spy0323 60 kDa inner membrane protein K03217 yidC; YidC/Oxa1 family membrane protein insertase D M6_Spy1526 SecA K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8] D M6_Spy0496 Cell division protein ftsY K03110 ftsY; fused signal recognition particle receptor D M6_Spy0904 signal recognition particle subunit FFH K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4] B B 09132 Signal transduction C 02020 Two-component system [PATH:spa02020] D M6_Spy0945 Phosphate-binding protein K02040 pstS; phosphate transport system substrate-binding protein D M6_Spy1885 Protease Do K04771 degP; serine protease Do [EC:3.4.21.107] D M6_Spy0470 VicK K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3] D M6_Spy0469 VicR K07668 vicR; two-component system, OmpR family, response regulator VicR D M6_Spy0001 chromosomal replication initiator protein K02313 dnaA; chromosomal replication initiator protein D M6_Spy1043 D-alanine-activating enzyme K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13] D M6_Spy1042 DltB K03739 dltB; membrane protein involved in D-alanine export D M6_Spy1041 D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13] D M6_Spy1040 DltD precursor K03740 dltD; D-alanine transfer protein D M6_Spy0936 CiaH K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3] D M6_Spy0937 CiaR K14983 ciaR; two-component system, OmpR family, response regulator CiaR D M6_Spy1496 D-alanyl-D-alanine carboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14] D M6_Spy0311 Transmembrane histidine kinase CsrS K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3] D M6_Spy0310 Response regulator CsrR K18941 arlR; two-component system, OmpR family, response regulator ArlR D M6_Spy1724 Two component system histidine kinase K18986 ihk; two-component system, OmpR family, sensor kinase Ihk [EC:2.7.13.3] D M6_Spy1725 Two-component response regulator K18987 irr; two-component system, OmpR family, response regulator Irr D M6_Spy0899 [Citrate [pro-3S]-lyase] ligase K01910 citC; [citrate (pro-3S)-lyase] ligase [EC:6.2.1.22] D M6_Spy0894 Citrate lyase acyl carrier protein K01646 citD; citrate lyase subunit gamma (acyl carrier protein) D M6_Spy0895 Citrate lyase beta chain K01644 citE; citrate lyase subunit beta / citryl-CoA lyase [EC:4.1.3.34] D M6_Spy0896 Citrate lyase alpha chain K01643 citF; citrate lyase subunit alpha / citrate CoA-transferase [EC:2.8.3.10] D M6_Spy0897 Apo-citrate lyase phosphoribosyl-dephospho-CoA transferase K05964 citX; holo-ACP synthase [EC:2.7.7.61] D M6_Spy0887 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A synthase K05966 citG; triphosphoribosyl-dephospho-CoA synthase [EC:2.4.2.52] D M6_Spy0831 NAD-dependent malic enzyme K00027 ME2; malate dehydrogenase (oxaloacetate-decarboxylating) [EC:1.1.1.38] D M6_Spy0830 Malate-sodium symport K11616 maeN; malate:Na+ symporter D M6_Spy1336 Sensory transduction protein kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D M6_Spy0235 FasB K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D M6_Spy0236 FasC K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D M6_Spy0237 FasA K07707 agrA; two-component system, LytTR family, response regulator AgrA D M6_Spy0287 Competence-specific sigma factor K12296 comX1_2; competence protein ComX D M6_Spy1626 Competence-specific sigma factor K12296 comX1_2; competence protein ComX D M6_Spy0010 Beta-lactamase K01467 ampC; beta-lactamase class C [EC:3.5.2.6] D M6_Spy1379 Two-component sensor protein yvqE K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3] D M6_Spy1378 Two-component response regulator yvqC K11618 liaR; two-component system, NarL family, response regulator LiaR D M6_Spy1635 Sensory transduction protein kinase K14988 salK; two-component system, NarL family, secretion system sensor histidine kinase SalK D M6_Spy1634 Transcriptional regulatory protein K14989 salR; two-component system, NarL family, secretion system response regulator SalR D M6_Spy1607 Glutamine synthetase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D M6_Spy1391 Acetate CoA-transferase alpha subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] D M6_Spy0167 Acetate CoA-transferase alpha subunit K01034 atoD; acetate CoA/acetoacetate CoA-transferase alpha subunit [EC:2.8.3.8 2.8.3.9] D M6_Spy1392 Acetate CoA-transferase beta subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] D M6_Spy0168 Acetate CoA-transferase beta subunit K01035 atoA; acetate CoA/acetoacetate CoA-transferase beta subunit [EC:2.8.3.8 2.8.3.9] D M6_Spy0163 Short-chain fatty acids transporter K02106 atoE; short-chain fatty acids transporter D M6_Spy0166 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy1390 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy0466 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy1324 Two-component sensor kinase yesM K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3] D M6_Spy1301 Two-component sensor kinase YesM K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3] D M6_Spy1323 Two-component response regulator yesN K07720 yesN; two-component system, response regulator YesN D M6_Spy0805 Two-component response regulator YesN K07720 yesN; two-component system, response regulator YesN D M6_Spy1302 Two-component response regulator YesN K07720 yesN; two-component system, response regulator YesN D M6_Spy0085 Protein tyrosine phosphatase K25307 wzb; low molecular weight protein-tyrosine phosphatase [EC:3.1.3.48] C 04010 MAPK signaling pathway C 04013 MAPK signaling pathway - fly C 04016 MAPK signaling pathway - plant C 04011 MAPK signaling pathway - yeast C 04012 ErbB signaling pathway C 04014 Ras signaling pathway C 04015 Rap1 signaling pathway C 04310 Wnt signaling pathway C 04330 Notch signaling pathway C 04340 Hedgehog signaling pathway C 04341 Hedgehog signaling pathway - fly C 04350 TGF-beta signaling pathway C 04390 Hippo signaling pathway C 04391 Hippo signaling pathway - fly C 04392 Hippo signaling pathway - multiple species C 04370 VEGF signaling pathway C 04371 Apelin signaling pathway C 04630 JAK-STAT signaling pathway C 04064 NF-kappa B signaling pathway C 04668 TNF signaling pathway C 04066 HIF-1 signaling pathway C 04068 FoxO signaling pathway C 04020 Calcium signaling pathway C 04070 Phosphatidylinositol signaling system C 04072 Phospholipase D signaling pathway C 04071 Sphingolipid signaling pathway C 04024 cAMP signaling pathway C 04022 cGMP-PKG signaling pathway C 04151 PI3K-Akt signaling pathway C 04152 AMPK signaling pathway C 04150 mTOR signaling pathway C 04075 Plant hormone signal transduction B B 09133 Signaling molecules and interaction C 04080 Neuroactive ligand-receptor interaction C 04060 Cytokine-cytokine receptor interaction C 04061 Viral protein interaction with cytokine and cytokine receptor C 04512 ECM-receptor interaction C 04514 Cell adhesion molecules # A09140 Cellular Processes B B 09141 Transport and catabolism C 04144 Endocytosis C 04145 Phagosome C 04142 Lysosome C 04146 Peroxisome C 04140 Autophagy - animal C 04138 Autophagy - yeast C 04136 Autophagy - other C 04137 Mitophagy - animal C 04139 Mitophagy - yeast C 04148 Efferocytosis B B 09143 Cell growth and death C 04110 Cell cycle C 04111 Cell cycle - yeast C 04112 Cell cycle - Caulobacter C 04113 Meiosis - yeast C 04114 Oocyte meiosis C 04210 Apoptosis C 04214 Apoptosis - fly C 04215 Apoptosis - multiple species C 04216 Ferroptosis C 04217 Necroptosis C 04115 p53 signaling pathway C 04218 Cellular senescence B B 09144 Cellular community - eukaryotes C 04510 Focal adhesion C 04520 Adherens junction C 04530 Tight junction C 04540 Gap junction C 04550 Signaling pathways regulating pluripotency of stem cells B B 09145 Cellular community - prokaryotes C 02024 Quorum sensing [PATH:spa02024] D M6_Spy1395 Autoinducer-2 production protein K07173 luxS; S-ribosylhomocysteine lyase [EC:4.4.1.21] D M6_Spy1704 Anthranilate synthase component II K01658 trpG; anthranilate synthase component II [EC:4.1.3.27] D M6_Spy0467 Long-chain-fatty-acid--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3] D M6_Spy1336 Sensory transduction protein kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D M6_Spy0235 FasB K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D M6_Spy0236 FasC K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D M6_Spy0237 FasA K07707 agrA; two-component system, LytTR family, response regulator AgrA D M6_Spy0188 Streptolysin O K11031 slo; thiol-activated cytolysin D M6_Spy0936 CiaH K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3] D M6_Spy0937 CiaR K14983 ciaR; two-component system, OmpR family, response regulator CiaR D M6_Spy0280 OppA K15580 oppA; oligopeptide transport system substrate-binding protein D M6_Spy0281 OppB K15581 oppB; oligopeptide transport system permease protein D M6_Spy0282 OppC K15582 oppC; oligopeptide transport system permease protein D M6_Spy0283 OppD K15583 oppD; oligopeptide transport system ATP-binding protein D M6_Spy0284 OppF K10823 oppF; oligopeptide transport system ATP-binding protein D M6_Spy0083 Transcriptional regulator K20342 comR; HTH-type transcriptional regulator, regulator for ComX D M6_Spy0287 Competence-specific sigma factor K12296 comX1_2; competence protein ComX D M6_Spy1626 Competence-specific sigma factor K12296 comX1_2; competence protein ComX D M6_Spy0433 Transcriptional regulator K20373 rgg2; HTH-type transcriptional regulator, SHP2-responsive activator D M6_Spy0474 Transcriptional regulator K20374 rgg3; HTH-type transcriptional regulator, SHP3-responsive repressor D M6_Spy1710 Dipeptide-binding protein K02035 ABC.PE.S; peptide/nickel transport system substrate-binding protein D M6_Spy1711 Dipeptide transport system permease protein dppB K02033 ABC.PE.P; peptide/nickel transport system permease protein D M6_Spy1712 Dipeptide transport system permease protein dppC K02034 ABC.PE.P1; peptide/nickel transport system permease protein D M6_Spy1713 Dipeptide transport ATP-binding protein dppD K02031 ddpD; peptide/nickel transport system ATP-binding protein D M6_Spy1714 Dipeptide transport ATP-binding protein dppF K02032 ddpF; peptide/nickel transport system ATP-binding protein D M6_Spy1738 Transcriptional regulator K20375 ropB; HTH-type transcriptional regulator, pheromone-responsive regulator D M6_Spy1735 Streptopain precursor K01364 speB; streptopain [EC:3.4.22.10] D M6_Spy1444 Tagatose-bisphosphate aldolase K01635 lacD; tagatose 1,6-diphosphate aldolase [EC:4.1.2.40] D M6_Spy1644 Tagatose-bisphosphate aldolase K01635 lacD; tagatose 1,6-diphosphate aldolase [EC:4.1.2.40] D M6_Spy0239 60 kDa inner membrane protein YIDC K03217 yidC; YidC/Oxa1 family membrane protein insertase D M6_Spy0323 60 kDa inner membrane protein K03217 yidC; YidC/Oxa1 family membrane protein insertase D M6_Spy1751 Protein translocase subunit secE K03073 secE; preprotein translocase subunit SecE D M6_Spy0440 Protein translocase subunit secG K03075 secG; preprotein translocase subunit SecG D M6_Spy0113 Protein translocase subunit secY K03076 secY; preprotein translocase subunit SecY D M6_Spy1685 Protein translocase subunit K03210 yajC; preprotein translocase subunit YajC D M6_Spy1526 SecA K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8] D M6_Spy0496 Cell division protein ftsY K03110 ftsY; fused signal recognition particle receptor D M6_Spy0904 signal recognition particle subunit FFH K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4] C 05111 Biofilm formation - Vibrio cholerae C 02025 Biofilm formation - Pseudomonas aeruginosa C 02026 Biofilm formation - Escherichia coli B B 09142 Cell motility C 02030 Bacterial chemotaxis C 02040 Flagellar assembly [PATH:spa02040] D M6_Spy0723 Cystine-binding protein K02424 tcyA; L-cystine transport system substrate-binding protein D M6_Spy0298 ABC transporter substrate-binding protein K02424 tcyA; L-cystine transport system substrate-binding protein D M6_Spy0617 RNA polymerase sigma factor rpoD K03086 rpoD; RNA polymerase primary sigma factor C 04814 Motor proteins C 04820 Cytoskeleton in muscle cells D M6_Spy0577 Enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] C 04810 Regulation of actin cytoskeleton # A09150 Organismal Systems B B 09151 Immune system C 04640 Hematopoietic cell lineage C 04610 Complement and coagulation cascades C 04611 Platelet activation C 04613 Neutrophil extracellular trap formation C 04620 Toll-like receptor signaling pathway C 04624 Toll and Imd signaling pathway C 04621 NOD-like receptor signaling pathway C 04622 RIG-I-like receptor signaling pathway C 04623 Cytosolic DNA-sensing pathway C 04625 C-type lectin receptor signaling pathway C 04650 Natural killer cell mediated cytotoxicity C 04612 Antigen processing and presentation C 04660 T cell receptor signaling pathway C 04658 Th1 and Th2 cell differentiation C 04659 Th17 cell differentiation C 04657 IL-17 signaling pathway C 04662 B cell receptor signaling pathway C 04664 Fc epsilon RI signaling pathway C 04666 Fc gamma R-mediated phagocytosis C 04670 Leukocyte transendothelial migration C 04672 Intestinal immune network for IgA production C 04062 Chemokine signaling pathway B B 09152 Endocrine system C 04911 Insulin secretion C 04910 Insulin signaling pathway C 04922 Glucagon signaling pathway C 04923 Regulation of lipolysis in adipocytes C 04920 Adipocytokine signaling pathway C 03320 PPAR signaling pathway C 04929 GnRH secretion C 04912 GnRH signaling pathway C 04913 Ovarian steroidogenesis C 04915 Estrogen signaling pathway C 04914 Progesterone-mediated oocyte maturation C 04917 Prolactin signaling pathway C 04921 Oxytocin signaling pathway C 04926 Relaxin signaling pathway C 04935 Growth hormone synthesis, secretion and action C 04918 Thyroid hormone synthesis C 04919 Thyroid hormone signaling pathway C 04928 Parathyroid hormone synthesis, secretion and action C 04916 Melanogenesis C 04924 Renin secretion C 04614 Renin-angiotensin system C 04925 Aldosterone synthesis and secretion C 04927 Cortisol synthesis and secretion B B 09153 Circulatory system C 04260 Cardiac muscle contraction C 04261 Adrenergic signaling in cardiomyocytes C 04270 Vascular smooth muscle contraction B B 09154 Digestive system C 04970 Salivary secretion C 04971 Gastric acid secretion C 04972 Pancreatic secretion C 04976 Bile secretion C 04973 Carbohydrate digestion and absorption C 04974 Protein digestion and absorption C 04975 Fat digestion and absorption C 04979 Cholesterol metabolism C 04977 Vitamin digestion and absorption C 04980 Cobalamin transport and metabolism C 04978 Mineral absorption B B 09155 Excretory system C 04962 Vasopressin-regulated water reabsorption C 04960 Aldosterone-regulated sodium reabsorption C 04961 Endocrine and other factor-regulated calcium reabsorption C 04964 Proximal tubule bicarbonate reclamation C 04966 Collecting duct acid secretion B B 09156 Nervous system C 04724 Glutamatergic synapse C 04727 GABAergic synapse C 04725 Cholinergic synapse C 04728 Dopaminergic synapse C 04726 Serotonergic synapse C 04720 Long-term potentiation C 04730 Long-term depression C 04723 Retrograde endocannabinoid signaling C 04721 Synaptic vesicle cycle C 04722 Neurotrophin signaling pathway B B 09157 Sensory system C 04744 Phototransduction C 04745 Phototransduction - fly C 04740 Olfactory transduction C 04742 Taste transduction C 04750 Inflammatory mediator regulation of TRP channels B B 09158 Development and regeneration C 04320 Dorso-ventral axis formation C 04360 Axon guidance C 04361 Axon regeneration C 04380 Osteoclast differentiation B B 09149 Aging C 04211 Longevity regulating pathway C 04212 Longevity regulating pathway - worm C 04213 Longevity regulating pathway - multiple species B B 09159 Environmental adaptation C 04710 Circadian rhythm C 04713 Circadian entrainment C 04711 Circadian rhythm - fly C 04712 Circadian rhythm - plant C 04714 Thermogenesis C 04626 Plant-pathogen interaction # A09160 Human Diseases B B 09161 Cancer: overview C 05200 Pathways in cancer C 05202 Transcriptional misregulation in cancer C 05206 MicroRNAs in cancer C 05205 Proteoglycans in cancer C 05204 Chemical carcinogenesis - DNA adducts C 05207 Chemical carcinogenesis - receptor activation C 05208 Chemical carcinogenesis - reactive oxygen species C 05203 Viral carcinogenesis C 05230 Central carbon metabolism in cancer C 05231 Choline metabolism in cancer C 05235 PD-L1 expression and PD-1 checkpoint pathway in cancer B B 09162 Cancer: specific types C 05210 Colorectal cancer C 05212 Pancreatic cancer C 05225 Hepatocellular carcinoma C 05226 Gastric cancer C 05214 Glioma C 05216 Thyroid cancer C 05221 Acute myeloid leukemia C 05220 Chronic myeloid leukemia C 05217 Basal cell carcinoma C 05218 Melanoma C 05211 Renal cell carcinoma C 05219 Bladder cancer C 05215 Prostate cancer C 05213 Endometrial cancer C 05224 Breast cancer C 05222 Small cell lung cancer C 05223 Non-small cell lung cancer B B 09172 Infectious disease: viral C 05166 Human T-cell leukemia virus 1 infection C 05170 Human immunodeficiency virus 1 infection C 05161 Hepatitis B C 05160 Hepatitis C C 05171 Coronavirus disease - COVID-19 C 05164 Influenza A C 05162 Measles C 05168 Herpes simplex virus 1 infection C 05163 Human cytomegalovirus infection C 05167 Kaposi sarcoma-associated herpesvirus infection C 05169 Epstein-Barr virus infection C 05165 Human papillomavirus infection B B 09171 Infectious disease: bacterial C 05110 Vibrio cholerae infection C 05120 Epithelial cell signaling in Helicobacter pylori infection C 05130 Pathogenic Escherichia coli infection C 05132 Salmonella infection C 05131 Shigellosis C 05135 Yersinia infection C 05133 Pertussis C 05134 Legionellosis C 05150 Staphylococcus aureus infection C 05152 Tuberculosis C 05100 Bacterial invasion of epithelial cells D M6_Spy0157 Fibronectin-binding protein K13734 sfb1; fibronectin-binding protein 1 B B 09174 Infectious disease: parasitic C 05146 Amoebiasis C 05144 Malaria C 05145 Toxoplasmosis C 05140 Leishmaniasis C 05142 Chagas disease C 05143 African trypanosomiasis B B 09163 Immune disease C 05310 Asthma C 05322 Systemic lupus erythematosus C 05323 Rheumatoid arthritis C 05320 Autoimmune thyroid disease C 05321 Inflammatory bowel disease C 05330 Allograft rejection C 05332 Graft-versus-host disease C 05340 Primary immunodeficiency B B 09164 Neurodegenerative disease C 05010 Alzheimer disease C 05012 Parkinson disease C 05014 Amyotrophic lateral sclerosis C 05016 Huntington disease C 05017 Spinocerebellar ataxia C 05020 Prion disease C 05022 Pathways of neurodegeneration - multiple diseases B B 09165 Substance dependence C 05030 Cocaine addiction C 05031 Amphetamine addiction C 05032 Morphine addiction C 05033 Nicotine addiction C 05034 Alcoholism B B 09166 Cardiovascular disease C 05417 Lipid and atherosclerosis C 05418 Fluid shear stress and atherosclerosis C 05410 Hypertrophic cardiomyopathy C 05412 Arrhythmogenic right ventricular cardiomyopathy C 05414 Dilated cardiomyopathy C 05415 Diabetic cardiomyopathy C 05416 Viral myocarditis B B 09167 Endocrine and metabolic disease C 04930 Type II diabetes mellitus C 04940 Type I diabetes mellitus C 04950 Maturity onset diabetes of the young C 04936 Alcoholic liver disease C 04932 Non-alcoholic fatty liver disease C 04931 Insulin resistance C 04933 AGE-RAGE signaling pathway in diabetic complications C 04934 Cushing syndrome B B 09175 Drug resistance: antimicrobial C 01501 beta-Lactam resistance [PATH:spa01501] D M6_Spy0010 Beta-lactamase K01467 ampC; beta-lactamase class C [EC:3.5.2.6] D M6_Spy0280 OppA K15580 oppA; oligopeptide transport system substrate-binding protein D M6_Spy0281 OppB K15581 oppB; oligopeptide transport system permease protein D M6_Spy0282 OppC K15582 oppC; oligopeptide transport system permease protein D M6_Spy0283 OppD K15583 oppD; oligopeptide transport system ATP-binding protein D M6_Spy0284 OppF K10823 oppF; oligopeptide transport system ATP-binding protein D M6_Spy1401 Multimodular transpeptidase-transglycosylase PBP 1A K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4] D M6_Spy0130 Multimodular transpeptidase-transglycosylase K03693 pbp1b; penicillin-binding protein 1B D M6_Spy1753 Multimodular transpeptidase-transglycosylase PBP 2A K12555 pbp2A; penicillin-binding protein 2A [EC:2.4.99.28 3.4.16.4] D M6_Spy1413 Division specific D,D-transpeptidase K12556 pbp2X; penicillin-binding protein 2X C 01502 Vancomycin resistance [PATH:spa01502] D M6_Spy1185 D-alanine--D-alanine ligase K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4] D M6_Spy1524 Alanine racemase K01775 alr; alanine racemase [EC:5.1.1.1] D M6_Spy1184 UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase K01929 murF; UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase [EC:6.3.2.10] D M6_Spy1412 Phospho-N-acetylmuramoyl-pentapeptide-transferase K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13] D M6_Spy1273 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227] D M6_Spy1496 D-alanyl-D-alanine carboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14] C 01503 Cationic antimicrobial peptide (CAMP) resistance [PATH:spa01503] D M6_Spy1885 Protease Do K04771 degP; serine protease Do [EC:3.4.21.107] D M6_Spy0395 Peptidyl-prolyl cis-trans isomerase K03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8] D M6_Spy1043 D-alanine-activating enzyme K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13] D M6_Spy1042 DltB K03739 dltB; membrane protein involved in D-alanine export D M6_Spy1041 D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13] D M6_Spy1040 DltD precursor K03740 dltD; D-alanine transfer protein D M6_Spy1735 Streptopain precursor K01364 speB; streptopain [EC:3.4.22.10] B B 09176 Drug resistance: antineoplastic C 01521 EGFR tyrosine kinase inhibitor resistance C 01524 Platinum drug resistance C 01523 Antifolate resistance C 01522 Endocrine resistance # A09180 Brite Hierarchies B B 09181 Protein families: metabolism C 01000 Enzymes [BR:spa01000] C 01001 Protein kinases [BR:spa01001] D M6_Spy1381 Serine/threonine protein kinase K12132 prkC; eukaryotic-like serine/threonine-protein kinase [EC:2.7.11.1] D M6_Spy0470 VicK K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3] D M6_Spy0936 CiaH K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3] D M6_Spy0311 Transmembrane histidine kinase CsrS K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3] D M6_Spy1724 Two component system histidine kinase K18986 ihk; two-component system, OmpR family, sensor kinase Ihk [EC:2.7.13.3] D M6_Spy1379 Two-component sensor protein yvqE K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3] D M6_Spy1635 Sensory transduction protein kinase K14988 salK; two-component system, NarL family, secretion system sensor histidine kinase SalK D M6_Spy0829 DpiB K02476 K02476; two-component system, CitB family, sensor kinase [EC:2.7.13.3] D M6_Spy1336 Sensory transduction protein kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D M6_Spy0235 FasB K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D M6_Spy0236 FasC K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D M6_Spy1324 Two-component sensor kinase yesM K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3] D M6_Spy1301 Two-component sensor kinase YesM K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3] C 01009 Protein phosphatases and associated proteins [BR:spa01009] D M6_Spy0976 Non-allosteric 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D M6_Spy1382 Protein phosphatase 2C K20074 prpC; PPM family protein phosphatase [EC:3.1.3.16] C 01002 Peptidases and inhibitors [BR:spa01002] D M6_Spy0655 Lipoprotein signal peptidase K03101 lspA; signal peptidase II [EC:3.4.23.36] D M6_Spy1402 Aminopeptidase C K01372 BLMH; bleomycin hydrolase [EC:3.4.22.40] D M6_Spy1735 Streptopain precursor K01364 speB; streptopain [EC:3.4.22.10] D M6_Spy0444 Pyrrolidone-carboxylate peptidase K01304 pcp; pyroglutamyl-peptidase [EC:3.4.19.3] D M6_Spy0908 GMP synthase [glutamine-hydrolyzing] K01951 guaA; GMP synthase (glutamine-hydrolysing) [EC:6.3.5.2] D M6_Spy0839 Glutamine amidotransferase, class I K07010 K07010; putative glutamine amidotransferase D M6_Spy0017 Secreted protein K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-] D M6_Spy0073 Amidophosphoribosyltransferase K00764 purF; amidophosphoribosyltransferase [EC:2.4.2.14] D M6_Spy0972 Glucosamine--fructose-6-phosphate aminotransferase [isomerizing] K00820 glmS; glutamine---fructose-6-phosphate transaminase (isomerizing) [EC:2.6.1.16] D M6_Spy0161 Sortase K07284 srtA; sortase A [EC:3.4.22.70] D M6_Spy0871 Sortase K07284 srtA; sortase A [EC:3.4.22.70] D M6_Spy0562 Dipeptidase K08659 pepDA; dipeptidase [EC:3.4.-.-] D M6_Spy1104 CAAX amino terminal protease family K07052 K07052; CAAX protease family protein D M6_Spy0582 SagE K07052 K07052; CAAX protease family protein D M6_Spy0938 Lysyl aminopeptidase K01256 pepN; aminopeptidase N [EC:3.4.11.2] D M6_Spy1111 Oligoendopeptidase F K08602 pepF; oligoendopeptidase F [EC:3.4.24.-] D M6_Spy1781 Neutral endopeptidase K07386 pepO; putative endopeptidase [EC:3.4.24.-] D M6_Spy1496 D-alanyl-D-alanine carboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14] D M6_Spy0810 Xaa-His dipeptidase K01274 pepV; beta-Ala-Xaa dipeptidase [EC:3.4.13.-] D M6_Spy0631 Peptidase T K01258 pepT; tripeptide aminopeptidase [EC:3.4.11.4] D M6_Spy1075 Methionine aminopeptidase K01265 map; methionyl aminopeptidase [EC:3.4.11.18] D M6_Spy0450 Xaa-Pro dipeptidase K01271 pepQ; Xaa-Pro dipeptidase [EC:3.4.13.9] D M6_Spy1538 Xaa-Pro dipeptidase K01262 pepP; Xaa-Pro aminopeptidase [EC:3.4.11.9] D M6_Spy0013 Cell division protein ftsH K03798 ftsH; cell division protease FtsH [EC:3.4.24.-] D M6_Spy0145 Glutamyl aminopeptidase K01261 pepA; glutamyl aminopeptidase [EC:3.4.11.7] D M6_Spy0308 HtpX K03799 htpX; heat shock protein HtpX [EC:3.4.24.-] D M6_Spy1682 Pheromone-processing membrane metalloprotease K11749 rseP; regulator of sigma E protease [EC:3.4.24.-] D M6_Spy1885 Protease Do K04771 degP; serine protease Do [EC:3.4.21.107] D M6_Spy0367 Lactocepin K01361 E3.4.21.96; lactocepin [EC:3.4.21.96] D M6_Spy1718 C5A peptidase precursor K08652 C5AP; C5a peptidase [EC:3.4.21.110] D M6_Spy0815 D-alanyl-D-alanine carboxypeptidase K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] D M6_Spy0279 D-alanyl-D-alanine carboxypeptidase K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] D M6_Spy1139 ATP-dependent Clp protease proteolytic subunit K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] D M6_Spy0354 ATP-dependent Clp protease proteolytic subunit K01358 clpP; ATP-dependent Clp protease, protease subunit [EC:3.4.21.92] D M6_Spy1588 Xaa-Pro dipeptidyl-peptidase K01281 pepX; X-Pro dipeptidyl-peptidase [EC:3.4.14.11] D M6_Spy1287 ATP-dependent protease La K07177 K07177; Lon-like protease D M6_Spy0903 Phage transcriptional repressor K01356 lexA; repressor LexA [EC:3.4.21.88] D M6_Spy1024 Phage transcriptional repressor K01356 lexA; repressor LexA [EC:3.4.21.88] D M6_Spy1577 Signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89] D M6_Spy0974 Signal peptidase I K03100 lepB; signal peptidase I [EC:3.4.21.89] D M6_Spy0513 Peptidase family U32 K08303 prtC; U32 family peptidase [EC:3.4.-.-] C 01003 Glycosyltransferases [BR:spa01003] D M6_Spy0453 1,2-diacylglycerol 3-glucosyltransferase K19002 mgs; 1,2-diacylglycerol 3-alpha-glucosyltransferase [EC:2.4.1.337] D M6_Spy1869 Hyaluronan synthase K00752 hasA; hyaluronan synthase [EC:2.4.1.212] D M6_Spy0452 Glycosyltransferase K13677 dgs; 1,2-diacylglycerol-3-alpha-glucose alpha-1,2-glucosyltransferase [EC:2.4.1.208] D M6_Spy1401 Multimodular transpeptidase-transglycosylase PBP 1A K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4] D M6_Spy0130 Multimodular transpeptidase-transglycosylase K03693 pbp1b; penicillin-binding protein 1B D M6_Spy1753 Multimodular transpeptidase-transglycosylase PBP 2A K12555 pbp2A; penicillin-binding protein 2A [EC:2.4.99.28 3.4.16.4] D M6_Spy0272 Undecaprenyl-phosphate alpha-N-acetylglucosaminephosphotransferase K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] C 01005 Lipopolysaccharide biosynthesis proteins [BR:spa01005] D M6_Spy0620 alpha-D-GlcNAc alpha-1,2-L-rhamnosyltransferase K12996 rgpA; rhamnosyltransferase [EC:2.4.1.-] D M6_Spy0621 alpha-L-Rha alpha-1,3-L-rhamnosyltransferase K12997 rgpB; rhamnosyltransferase [EC:2.4.1.-] D M6_Spy0624 Glycosyltransferase K12998 rgpE; glucosyltransferase [EC:2.4.1.-] D M6_Spy0625 alpha-L-Rha alpha-1,2-L-rhamnosyltransferase K07272 rgpF; rhamnosyltransferase [EC:2.4.1.-] D M6_Spy0272 Undecaprenyl-phosphate alpha-N-acetylglucosaminephosphotransferase K02851 wecA; UDP-GlcNAc:undecaprenyl-phosphate/decaprenyl-phosphate GlcNAc-1-phosphate transferase [EC:2.7.8.33 2.7.8.35] D M6_Spy0447 Bactoprenol glucosyl transferase K12999 rgpI; glucosyltransferase [EC:2.4.1.-] C 01011 Peptidoglycan biosynthesis and degradation proteins [BR:spa01011] D M6_Spy0601 UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] D M6_Spy1081 UDP-N-acetylglucosamine 1-carboxyvinyltransferase K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] D M6_Spy0823 UDP-N-acetylenolpyruvoylglucosamine reductase K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98] D M6_Spy0318 UDP-N-acetylmuramate--alanine ligase K01924 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8] D M6_Spy1274 UDP-N-acetylmuramoylalanine--D-glutamate ligase K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9] D M6_Spy0351 UDP-N-acetylmuramoyl-L-alanyl-D-glutamate--lysine ligase K05362 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase [EC:6.3.2.7] D M6_Spy1185 D-alanine--D-alanine ligase K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4] D M6_Spy0909 UDP-N-acetylmuramoylpentapeptide-lysine N(6)-alanyltransferase K05363 murM; serine/alanine adding enzyme [EC:2.3.2.10] D M6_Spy0532 Factor essential for expression of methicillin resistance K05363 murM; serine/alanine adding enzyme [EC:2.3.2.10] D M6_Spy0531 Factor essential for expression of methicillin resistance K12554 murN; alanine adding enzyme [EC:2.3.2.-] D M6_Spy1524 Alanine racemase K01775 alr; alanine racemase [EC:5.1.1.1] D M6_Spy0329 Glutamate racemase K01776 murI; glutamate racemase [EC:5.1.1.3] D M6_Spy1412 Phospho-N-acetylmuramoyl-pentapeptide-transferase K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13] D M6_Spy1273 UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227] D M6_Spy0270 Bacitracin resistance protein K06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27] D M6_Spy0340 Membrane-associated phospholipid phosphatase K19302 bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27] D M6_Spy1401 Multimodular transpeptidase-transglycosylase PBP 1A K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4] D M6_Spy0130 Multimodular transpeptidase-transglycosylase K03693 pbp1b; penicillin-binding protein 1B D M6_Spy1753 Multimodular transpeptidase-transglycosylase PBP 2A K12555 pbp2A; penicillin-binding protein 2A [EC:2.4.99.28 3.4.16.4] D M6_Spy1413 Division specific D,D-transpeptidase K12556 pbp2X; penicillin-binding protein 2X D M6_Spy0815 D-alanyl-D-alanine carboxypeptidase K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] D M6_Spy0279 D-alanyl-D-alanine carboxypeptidase K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] D M6_Spy1496 D-alanyl-D-alanine carboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14] D M6_Spy0017 Secreted protein K21471 cwlO; peptidoglycan DL-endopeptidase CwlO [EC:3.4.-.-] D M6_Spy0161 Sortase K07284 srtA; sortase A [EC:3.4.22.70] D M6_Spy0871 Sortase K07284 srtA; sortase A [EC:3.4.22.70] D M6_Spy0320 Aminodeoxychorismate lyase family K07082 mltG; peptidoglycan lytic transglycosylase G [EC:4.2.2.29] C 01004 Lipid biosynthesis proteins [BR:spa01004] D M6_Spy1485 Malonyl-CoA-[acyl-carrier-protein] transacylase K00645 fabD; [acyl-carrier-protein] S-malonyltransferase [EC:2.3.1.39] D M6_Spy1488 3-oxoacyl-[acyl-carrier-protein] synthase III K00648 fabH; 3-oxoacyl-[acyl-carrier-protein] synthase III [EC:2.3.1.180] D M6_Spy1483 3-oxoacyl-[acyl-carrier-protein] synthase K09458 fabF; 3-oxoacyl-[acyl-carrier-protein] synthase II [EC:2.3.1.179] D M6_Spy0383 Short chain dehydrogenase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D M6_Spy1484 3-oxoacyl-[acyl-carrier protein] reductase K00059 fabG; 3-oxoacyl-[acyl-carrier protein] reductase [EC:1.1.1.100] D M6_Spy1481 (3R)-hydroxyacyl-[acyl carrier protein] dehydratase K02372 fabZ; 3-hydroxyacyl-[acyl-carrier-protein] dehydratase [EC:4.2.1.59] D M6_Spy1486 Enoyl-[acyl-carrier protein] reductase (NADH) K02371 fabK; enoyl-[acyl-carrier protein] reductase II [EC:1.3.1.9] D M6_Spy1490 Enoyl-CoA hydratase K18474 fabM; trans-2-decenoyl-[acyl-carrier protein] isomerase [EC:5.3.3.14] D M6_Spy0467 Long-chain-fatty-acid--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3] D M6_Spy0069 Fatty acid/phospholipid synthesis protein plsX K03621 plsX; phosphate acyltransferase [EC:2.3.1.274] D M6_Spy0727 Hypothetical membrane spanning protein K08591 plsY; acyl phosphate:glycerol-3-phosphate acyltransferase [EC:2.3.1.275] D M6_Spy1177 1-acyl-sn-glycerol-3-phosphate acyltransferase K00655 plsC; 1-acyl-sn-glycerol-3-phosphate acyltransferase [EC:2.3.1.51] C 01008 Polyketide biosynthesis proteins C 01006 Prenyltransferases [BR:spa01006] D M6_Spy1251 Dimethylallyltransferase K13789 GGPS; geranylgeranyl diphosphate synthase, type II [EC:2.5.1.1 2.5.1.10 2.5.1.29] D M6_Spy1684 Undecaprenyl pyrophosphate synthetase K00806 uppS; undecaprenyl diphosphate synthase [EC:2.5.1.31] D M6_Spy0748 tRNA delta(2)-isopentenylpyrophosphate transferase K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75] C 01007 Amino acid related enzymes [BR:spa01007] D M6_Spy0234 Glutamyl-tRNA synthetase K09698 gltX; nondiscriminating glutamyl-tRNA synthetase [EC:6.1.1.24] D M6_Spy0129 Tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1] D M6_Spy1876 Tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2] D M6_Spy1663 Cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16] D M6_Spy1827 Arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19] D M6_Spy0370 Methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10] D M6_Spy1264 Isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5] D M6_Spy1310 Valyl-tRNA synthetase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9] D M6_Spy0193 Leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4] D M6_Spy0516 Lysyl-tRNA synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6] D M6_Spy1832 Aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12] D M6_Spy0558 Asparaginyl-tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22] D M6_Spy1833 Histidyl-tRNA synthetase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21] D M6_Spy1433 Glycyl-tRNA synthetase alpha chain K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14] D M6_Spy1432 Glycyl-tRNA synthetase beta chain K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14] D M6_Spy1477 Seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11] D M6_Spy1681 Prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15] D M6_Spy0454 Threonyl-tRNA synthetase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3] D M6_Spy1107 Alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7] D M6_Spy0604 Phenylalanyl-tRNA synthetase alpha chain K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20] D M6_Spy0605 Phenylalanyl-tRNA synthetase beta chain K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20] D M6_Spy1506 Aspartate aminotransferase K14260 alaA; alanine-synthesizing transaminase [EC:2.6.1.66 2.6.1.2] D M6_Spy0730 Branched-chain amino acid aminotransferase K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42] D M6_Spy1703 Para-aminobenzoate synthetase component I K03342 pabBC; para-aminobenzoate synthetase / 4-amino-4-deoxychorismate lyase [EC:2.6.1.85 4.1.3.38] C 00199 Cytochrome P450 C 00194 Photosynthesis proteins [BR:spa00194] D M6_Spy0599 ATP synthase epsilon chain K02114 ATPF1E; F-type H+-transporting ATPase subunit epsilon D M6_Spy0598 ATP synthase beta chain K02112 ATPF1B; F-type H+/Na+-transporting ATPase subunit beta [EC:7.1.2.2 7.2.2.1] D M6_Spy0597 ATP synthase gamma chain K02115 ATPF1G; F-type H+-transporting ATPase subunit gamma D M6_Spy0596 ATP synthase alpha chain K02111 ATPF1A; F-type H+/Na+-transporting ATPase subunit alpha [EC:7.1.2.2 7.2.2.1] D M6_Spy0595 ATP synthase delta chain K02113 ATPF1D; F-type H+-transporting ATPase subunit delta D M6_Spy0594 ATP synthase B chain K02109 ATPF0B; F-type H+-transporting ATPase subunit b D M6_Spy0592 ATP synthase C chain K02110 ATPF0C; F-type H+-transporting ATPase subunit c D M6_Spy0593 ATP synthase A chain K02108 ATPF0A; F-type H+-transporting ATPase subunit a B B 09182 Protein families: genetic information processing C 03000 Transcription factors [BR:spa03000] D M6_Spy1143 DNA-cytosine methyltransferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D M6_Spy1160 Type II restriction-modification system methylation subunit K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D M6_Spy1451 Lactose phosphotransferase system repressor K02530 lacR; DeoR family transcriptional regulator, lactose phosphotransferase system repressor D M6_Spy1648 Lactose phosphotransferase system repressor K02530 lacR; DeoR family transcriptional regulator, lactose phosphotransferase system repressor D M6_Spy0679 Fructose repressor K03436 fruR2; DeoR family transcriptional regulator, fructose operon transcriptional repressor D M6_Spy1285 Ribose operon repressor K02529 galR; LacI family transcriptional regulator, galactose operon repressor D M6_Spy1031 Transcriptional regulator, LacI family K02529 galR; LacI family transcriptional regulator, galactose operon repressor D M6_Spy0451 Catabolite control protein A K02529 galR; LacI family transcriptional regulator, galactose operon repressor D M6_Spy0538 Transcriptional regulator, LacI family K02525 kdgR; LacI family transcriptional regulator, kdg operon repressor D M6_Spy1533 Sucrose operon repressor K03484 scrR; LacI family transcriptional regulator, sucrose operon repressor D M6_Spy1333 Transcriptional regulator, GntR family K02103 araR; GntR family transcriptional regulator, arabinose operon transcriptional repressor D M6_Spy1784 Trehalose operon transcriptional repressor K03486 treR2; GntR family transcriptional regulator, trehalose operon transcriptional repressor D M6_Spy0906 Transcriptional regulator, GntR family K24967 nagR; GntR family transcriptional regulator, N-acetylglucosamine utilization regulator D M6_Spy0564 Transcriptional regulator, GntR family K24967 nagR; GntR family transcriptional regulator, N-acetylglucosamine utilization regulator D M6_Spy1608 Transcriptional regulator, MerR family K03713 glnR; MerR family transcriptional regulator, glutamine synthetase repressor D M6_Spy0207 Ferric uptake regulation protein K09825 perR; Fur family transcriptional regulator, peroxide stress response regulator D M6_Spy1297 Transcription regulator, crp family K21828 arcR; CRP/FNR family transcriptional regulator, arginine deiminase pathway regulator D M6_Spy1837 Cadmium efflux system accessory protein K21903 cadC; ArsR family transcriptional regulator, lead/cadmium/zinc/bismuth-responsive transcriptional repressor D M6_Spy1846 Transcriptional regulator, PadR family K10947 K10947; PadR family transcriptional regulator D M6_Spy0391 Iron-dependent repressor K03709 troR; DtxR family transcriptional regulator, Mn-dependent transcriptional regulator D M6_Spy1084 Biotin operon repressor K03524 birA; BirA family transcriptional regulator, biotin operon repressor / biotin---[acetyl-CoA-carboxylase] ligase [EC:6.3.4.15] D M6_Spy0083 Transcriptional regulator K20342 comR; HTH-type transcriptional regulator, regulator for ComX D M6_Spy0433 Transcriptional regulator K20373 rgg2; HTH-type transcriptional regulator, SHP2-responsive activator D M6_Spy0474 Transcriptional regulator K20374 rgg3; HTH-type transcriptional regulator, SHP3-responsive repressor D M6_Spy1738 Transcriptional regulator K20375 ropB; HTH-type transcriptional regulator, pheromone-responsive regulator D M6_Spy0260 Pur operon repressor K09685 purR; HTH-type transcriptional regulator, purine operon repressor D M6_Spy0840 Redox-sensitive transcriptional regulator K01926 rex; redox-sensing transcriptional repressor D M6_Spy1505 Transcription pleiotropic repressor K03706 codY; transcriptional pleiotropic repressor D M6_Spy1807 HTH DNA-binding protein K07727 K07727; putative transcriptional regulator D M6_Spy1806 Transcriptional regulator, Cro/CI family K07727 K07727; putative transcriptional regulator D M6_Spy1106 Transcriptional regulator, Cro/CI family K07729 K07729; putative transcriptional regulator D M6_Spy1656 Transcriptional regulator, Cro/CI family K07729 K07729; putative transcriptional regulator D M6_Spy0498 Transcription antiterminator, BglG family K03488 licT; beta-glucoside operon transcriptional antiterminator D M6_Spy0201 Transcription antiterminator, BglG family K03493 bglG1; transcriptional antiterminator D M6_Spy1052 Transcription antiterminator, BglG family K03491 licR; probable licABCH operon transcriptional regulator D M6_Spy1886 Chromosome partitioning protein K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein D M6_Spy1298 Arginine repressor, argR K03402 argR; transcriptional regulator of arginine metabolism D M6_Spy1826 ArgR K03402 argR; transcriptional regulator of arginine metabolism D M6_Spy1249 Arginine repressor K03402 argR; transcriptional regulator of arginine metabolism D M6_Spy1494 Heat-inducible transcription repressor K03705 hrcA; heat-inducible transcriptional repressor D M6_Spy1763 CtsR K03708 ctsR; transcriptional regulator of stress and heat shock response D M6_Spy0657 Uracil phosphoribosyltransferase K02825 pyrR; pyrimidine operon attenuation protein / uracil phosphoribosyltransferase [EC:2.4.2.9] D M6_Spy0312 Putative regulatory protein K07738 nrdR; transcriptional repressor NrdR D M6_Spy0287 Competence-specific sigma factor K12296 comX1_2; competence protein ComX D M6_Spy1626 Competence-specific sigma factor K12296 comX1_2; competence protein ComX C 03021 Transcription machinery [BR:spa03021] D M6_Spy0119 DNA-directed RNA polymerase alpha chain K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6] D M6_Spy0131 DNA-directed RNA polymerase beta chain K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6] D M6_Spy0132 DNA-directed RNA polymerase beta' chain K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6] D M6_Spy1619 DNA-directed RNA polymerase delta chain K03048 rpoE; DNA-directed RNA polymerase subunit delta D M6_Spy1386 DNA-directed RNA polymerase omega chain K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6] D M6_Spy0617 RNA polymerase sigma factor rpoD K03086 rpoD; RNA polymerase primary sigma factor D M6_Spy1460 N utilization substance protein A K02600 nusA; transcription termination/antitermination protein NusA D M6_Spy1534 N utilization substance protein B K03625 nusB; transcription antitermination protein NusB D M6_Spy0185 Transcription antitermination protein K02601 nusG; transcription termination/antitermination protein NusG D M6_Spy0321 Transcription elongation factor K03624 greA; transcription elongation factor GreA C 03019 Messenger RNA biogenesis [BR:spa03019] D M6_Spy0472 Ribonuclease III K03685 rnc; ribonuclease III [EC:3.1.26.3] D M6_Spy1606 Zn-dependent hydrolase K12574 rnj; ribonuclease J [EC:3.1.-.-] D M6_Spy0772 Zn-dependent hydrolase K12574 rnj; ribonuclease J [EC:3.1.-.-] D M6_Spy1388 Hydrolase (HAD superfamily) K18682 rny; ribonucrease Y [EC:3.1.-.-] D M6_Spy0441 Exoribonuclease II K12573 rnr; ribonuclease R [EC:3.1.13.1] D M6_Spy0259 CMP-binding factor K03698 cbf; 3'-5' exoribonuclease [EC:3.1.-.-] D M6_Spy1180 ATP-dependent RNA helicase K05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7] D M6_Spy1411 ATP-dependent RNA helicase K18692 cshB; ATP-dependent RNA helicase CshB [EC:5.6.2.7] D M6_Spy0577 Enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] D M6_Spy1668 Polyribonucleotide nucleotidyltransferase K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8] D M6_Spy0976 Non-allosteric 6-phosphofructokinase K00850 pfkA; 6-phosphofructokinase 1 [EC:2.7.1.11] D M6_Spy1492 DnaK K04043 dnaK; molecular chaperone DnaK D M6_Spy1760 60 kDa chaperonin GROEL K04077 groEL; chaperonin GroEL [EC:5.6.1.7] D M6_Spy0559 ATP-binding protein K06958 rapZ; RNase adapter protein RapZ C 03041 Spliceosome C 03011 Ribosome [BR:spa03011] D M6_Spy0732 SSU ribosomal protein S1P K02945 RP-S1; small subunit ribosomal protein S1 D M6_Spy1779 SSU ribosomal protein S2P K02967 RP-S2; small subunit ribosomal protein S2 D M6_Spy0099 SSU ribosomal protein S3P K02982 RP-S3; small subunit ribosomal protein S3 D M6_Spy1851 SSU ribosomal protein S4P K02986 RP-S4; small subunit ribosomal protein S4 D M6_Spy0110 SSU ribosomal protein S5P K02988 RP-S5; small subunit ribosomal protein S5 D M6_Spy1567 SSU ribosomal protein S6P K02990 RP-S6; small subunit ribosomal protein S6 D M6_Spy0263 SSU ribosomal protein S7P K02992 RP-S7; small subunit ribosomal protein S7 D M6_Spy0107 SSU ribosomal protein S8P K02994 RP-S8; small subunit ribosomal protein S8 D M6_Spy1654 SSU ribosomal protein S9P K02996 RP-S9; small subunit ribosomal protein S9 D M6_Spy0092 SSU ribosomal protein S10P K02946 RP-S10; small subunit ribosomal protein S10 D M6_Spy0118 SSU ribosomal protein S11P K02948 RP-S11; small subunit ribosomal protein S11 D M6_Spy0262 SSU ribosomal protein S12P K02950 RP-S12; small subunit ribosomal protein S12 D M6_Spy0117 SSU ribosomal protein S13P K02952 RP-S13; small subunit ribosomal protein S13 D M6_Spy0106 SSU ribosomal protein S14P K02954 RP-S14; small subunit ribosomal protein S14 D M6_Spy1601 SSU ribosomal protein S14P K02954 RP-S14; small subunit ribosomal protein S14 D M6_Spy1674 SSU ribosomal protein S15P K02956 RP-S15; small subunit ribosomal protein S15 D M6_Spy0667 SSU ribosomal protein S16P K02959 RP-S16; small subunit ribosomal protein S16 D M6_Spy0102 SSU ribosomal protein S17P K02961 RP-S17; small subunit ribosomal protein S17 D M6_Spy1565 SSU ribosomal protein S18P K02963 RP-S18; small subunit ribosomal protein S18 D M6_Spy0097 SSU ribosomal protein S19P K02965 RP-S19; small subunit ribosomal protein S19 D M6_Spy0935 SSU ribosomal protein S20P K02968 RP-S20; small subunit ribosomal protein S20 D M6_Spy0614 SSU ribosomal protein S21P K02970 RP-S21; small subunit ribosomal protein S21 D M6_Spy0402 LSU ribosomal protein L1P K02863 RP-L1; large subunit ribosomal protein L1 D M6_Spy0096 LSU ribosomal protein L2P K02886 RP-L2; large subunit ribosomal protein L2 D M6_Spy0093 LSU ribosomal protein L3P K02906 RP-L3; large subunit ribosomal protein L3 D M6_Spy0094 LSU ribosomal protein L1E K02926 RP-L4; large subunit ribosomal protein L4 D M6_Spy0105 LSU ribosomal protein L5P K02931 RP-L5; large subunit ribosomal protein L5 D M6_Spy0108 LSU ribosomal protein L6P K02933 RP-L6; large subunit ribosomal protein L6 D M6_Spy1854 LSU ribosomal protein L9P K02939 RP-L9; large subunit ribosomal protein L9 D M6_Spy0813 LSU ribosomal protein L10P K02864 RP-L10; large subunit ribosomal protein L10 D M6_Spy0401 LSU ribosomal protein L11P K02867 RP-L11; large subunit ribosomal protein L11 D M6_Spy0814 LSU ribosomal protein L12P (L7/L12) K02935 RP-L7; large subunit ribosomal protein L7/L12 D M6_Spy1655 LSU ribosomal protein L13P K02871 RP-L13; large subunit ribosomal protein L13 D M6_Spy0103 LSU ribosomal protein L14P K02874 RP-L14; large subunit ribosomal protein L14 D M6_Spy0112 LSU ribosomal protein L15P K02876 RP-L15; large subunit ribosomal protein L15 D M6_Spy0100 LSU ribosomal protein L16P K02878 RP-L16; large subunit ribosomal protein L16 D M6_Spy0120 LSU ribosomal protein L17P K02879 RP-L17; large subunit ribosomal protein L17 D M6_Spy0109 LSU ribosomal protein L18P K02881 RP-L18; large subunit ribosomal protein L18 D M6_Spy0571 LSU ribosomal protein L19P K02884 RP-L19; large subunit ribosomal protein L19 D M6_Spy0638 LSU ribosomal protein L20P K02887 RP-L20; large subunit ribosomal protein L20 D M6_Spy0651 LSU ribosomal protein L21P K02888 RP-L21; large subunit ribosomal protein L21 D M6_Spy0098 LSU ribosomal protein L22P K02890 RP-L22; large subunit ribosomal protein L22 D M6_Spy0095 LSU ribosomal protein L23P K02892 RP-L23; large subunit ribosomal protein L23 D M6_Spy0104 LSU ribosomal protein L24P K02895 RP-L24; large subunit ribosomal protein L24 D M6_Spy0653 LSU ribosomal protein L27P K02899 RP-L27; large subunit ribosomal protein L27 D M6_Spy1615 LSU ribosomal protein L28P K02902 RP-L28; large subunit ribosomal protein L28 D M6_Spy0101 LSU ribosomal protein L29P K02904 RP-L29; large subunit ribosomal protein L29 D M6_Spy0111 LSU ribosomal protein L30P K02907 RP-L30; large subunit ribosomal protein L30 D M6_Spy0566 LSU ribosomal protein L31P K02909 RP-L31; large subunit ribosomal protein L31 D M6_Spy1834 LSU ribosomal protein L32P K02911 RP-L32; large subunit ribosomal protein L32 D M6_Spy0439 LSU ribosomal protein L33P K02913 RP-L33; large subunit ribosomal protein L33 D M6_Spy1752 LSU ribosomal protein L33P K02913 RP-L33; large subunit ribosomal protein L33 D M6_Spy1835 LSU ribosomal protein L33P K02913 RP-L33; large subunit ribosomal protein L33 D M6_Spy0242 LSU ribosomal protein L34P K02914 RP-L34; large subunit ribosomal protein L34 D M6_Spy0637 LSU ribosomal protein L35P K02916 RP-L35; large subunit ribosomal protein L35 D M6_Spy0116 LSU ribosomal protein L36P K02919 RP-L36; large subunit ribosomal protein L36 D M6_Spys1890 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D M6_Spys1903 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D M6_Spys1924 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D M6_Spys1940 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D M6_Spys1955 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D M6_Spys1963 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D M6_Spys1887 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D M6_Spys1900 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D M6_Spys1921 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D M6_Spys1937 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D M6_Spys1958 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D M6_Spys1966 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D M6_Spys1889 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D M6_Spys1902 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D M6_Spys1923 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D M6_Spys1939 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D M6_Spys1956 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D M6_Spys1964 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA C 03009 Ribosome biogenesis [BR:spa03009] D M6_Spy0472 Ribonuclease III K03685 rnc; ribonuclease III [EC:3.1.26.3] D M6_Spy0415 GTP-binding protein era K03595 era; GTPase D M6_Spy1057 CgtA K03979 obgE; GTPase [EC:3.6.5.-] D M6_Spy1460 N utilization substance protein A K02600 nusA; transcription termination/antitermination protein NusA D M6_Spy1534 N utilization substance protein B K03625 nusB; transcription antitermination protein NusB D M6_Spy0185 Transcription antitermination protein K02601 nusG; transcription termination/antitermination protein NusG D M6_Spy1113 Ribosomal small subunit pseudouridine synthase A K06183 rsuA; 16S rRNA pseudouridine516 synthase [EC:5.4.99.19] D M6_Spy1064 Ribosomal small subunit pseudouridine synthase A K06183 rsuA; 16S rRNA pseudouridine516 synthase [EC:5.4.99.19] D M6_Spy0254 Dimethyladenosine transferase K02528 ksgA; 16S rRNA (adenine1518-N6/adenine1519-N6)-dimethyltransferase [EC:2.1.1.182] D M6_Spy1383 16S rRNA m(5)C 967 methyltransferase K03500 rsmB; 16S rRNA (cytosine967-C5)-methyltransferase [EC:2.1.1.176] D M6_Spy0933 16S rRNA m(2)G 1207 methyltransferase K00564 rsmC; 16S rRNA (guanine1207-N2)-methyltransferase [EC:2.1.1.172] D M6_Spy1289 Methyltransferase K08316 rsmD; 16S rRNA (guanine966-N2)-methyltransferase [EC:2.1.1.171] D M6_Spy1699 Hypothetical cytosolic protein K09761 rsmE; 16S rRNA (uracil1498-N3)-methyltransferase [EC:2.1.1.193] D M6_Spy0306 Methyltransferase K03501 gidB; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170] D M6_Spy1415 S-adenosyl-methyltransferase K03438 mraW; 16S rRNA (cytosine1402-N4)-methyltransferase [EC:2.1.1.199] D M6_Spy0361 corrin/porphyrin methyltransferase K07056 rsmI; 16S rRNA (cytidine1402-2'-O)-methyltransferase [EC:2.1.1.198] D M6_Spy1250 Hemolysin K06442 tlyA; 23S rRNA (cytidine1920-2'-O)/16S rRNA (cytidine1409-2'-O)-methyltransferase [EC:2.1.1.226 2.1.1.227] D M6_Spy1660 23S rRNA Gm2251 methyltransferase K03218 rlmB; 23S rRNA (guanosine2251-2'-O)-methyltransferase [EC:2.1.1.185] D M6_Spy1884 Hypothetical cytosolic protein K00783 rlmH; 23S rRNA (pseudouridine1915-N3)-methyltransferase [EC:2.1.1.177] D M6_Spy0640 Methyltransferase K06969 rlmI; 23S rRNA (cytosine1962-C5)-methyltransferase [EC:2.1.1.191] D M6_Spy1282 Florfenicol resistance protein K06941 rlmN; 23S rRNA (adenine2503-C2)-methyltransferase [EC:2.1.1.192] D M6_Spy1070 23S rRNA m(5)U 1939 methyltransferase K03215 rumA; 23S rRNA (uracil1939-C5)-methyltransferase [EC:2.1.1.190] D M6_Spy0336 Ribosomal large subunit pseudouridine synthase B K06178 rluB; 23S rRNA pseudouridine2605 synthase [EC:5.4.99.22] D M6_Spy0656 Ribosomal large subunit pseudouridine synthase D K06180 rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23] D M6_Spy1756 Ribosomal large subunit pseudouridine synthase D K06180 rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23] D M6_Spy0847 Ribosomal large subunit pseudouridine synthase D K06180 rluD; 23S rRNA pseudouridine1911/1915/1917 synthase [EC:5.4.99.23] D M6_Spy1603 Ribosomal-protein-alanine acetyltransferase K03789 rimI; [ribosomal protein S18]-alanine N-acetyltransferase [EC:2.3.1.266] D M6_Spy0674 16S rRNA processing protein K02860 rimM; 16S rRNA processing protein RimM D M6_Spy1700 Ribosomal protein L11 methyltransferase K02687 prmA; ribosomal protein L11 methyltransferase [EC:2.1.1.-] D M6_Spy1795 Endonuclease involved in recombination K07447 ruvX; putative pre-16S rRNA nuclease [EC:3.1.-.-] D M6_Spy1662 Hypothetical Protein K11145 mrnC; mini-ribonuclease III [EC:3.1.26.-] D M6_Spy1180 ATP-dependent RNA helicase K05592 deaD; ATP-dependent RNA helicase DeaD [EC:5.6.2.7] D M6_Spy1411 ATP-dependent RNA helicase K18692 cshB; ATP-dependent RNA helicase CshB [EC:5.6.2.7] D M6_Spy0255 GTPase K06949 rsgA; ribosome biogenesis GTPase / thiamine phosphate phosphatase [EC:3.6.1.- 3.1.3.100] D M6_Spy0315 GTP-binding protein K03977 engA; GTPase D M6_Spy0878 GTP-binding protein K14540 rbgA; ribosome biogenesis GTPase A D M6_Spy0749 HflX K03665 hflX; GTPase D M6_Spy0289 GTP-binding protein K06948 yqeH; 30S ribosome assembly GTPase D M6_Spy0861 Sua5 K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87] D M6_Spy1694 GTP pyrophosphokinase K01139 spoT; GTP diphosphokinase / guanosine-3',5'-bis(diphosphate) 3'-diphosphatase [EC:2.7.6.5 3.1.7.2] D M6_Spy1456 Ribosome-binding factor A K02834 rbfA; ribosome-binding factor A D M6_Spy1461 Hypothetical cytosolic protein K09748 rimP; ribosome maturation factor RimP D M6_Spy1872 Hypothetical cytosolic protein K14761 rlbA; ribosome-associated protein D M6_Spy0293 iojap protein family K09710 ybeB; ribosome-associated protein D M6_Spy0413 Hypothetical Metal-Binding Protein K07042 ybeY; probable rRNA maturation factor D M6_Spy0290 Hypothetical RNA binding protein K07574 yhbY; RNA-binding protein D M6_Spy1371 Ribosome-associated factor Y K05808 hpf; ribosome hibernation promoting factor D M6_Spy0004 GTP-binding protein K06942 ychF; ribosome-binding ATPase D M6_Spy0309 Hypothetical cytosolic protein K07040 yceD; DUF177 domain-containing protein C 03016 Transfer RNA biogenesis [BR:spa03016] D M6_Spy0751 Metal-dependent hydrolase K00784 rnz; ribonuclease Z [EC:3.1.26.11] D M6_Spy0691 poly(A) polymerase K00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-] D M6_Spy1681 Prolyl-tRNA synthetase K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15] D M6_Spy1264 Isoleucyl-tRNA synthetase K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5] D M6_Spy0193 Leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4] D M6_Spy0370 Methionyl-tRNA synthetase K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10] D M6_Spy1827 Arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19] D M6_Spy0516 Lysyl-tRNA synthetase K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6] D M6_Spy1832 Aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12] D M6_Spy1107 Alanyl-tRNA synthetase K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7] D M6_Spy0558 Asparaginyl-tRNA synthetase K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22] D M6_Spy0454 Threonyl-tRNA synthetase K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3] D M6_Spy1477 Seryl-tRNA synthetase K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11] D M6_Spy1663 Cysteinyl-tRNA synthetase K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16] D M6_Spy1310 Valyl-tRNA synthetase K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9] D M6_Spy1833 Histidyl-tRNA synthetase K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21] D M6_Spy0604 Phenylalanyl-tRNA synthetase alpha chain K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20] D M6_Spy0605 Phenylalanyl-tRNA synthetase beta chain K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20] D M6_Spy0129 Tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1] D M6_Spy1876 Tryptophanyl-tRNA synthetase K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2] D M6_Spy1693 D-tyrosyl-tRNA(Tyr) deacylase K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96] D M6_Spy1466 Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-] D M6_Spy1462 tRNA (m(7)G46) methyltransferase K03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33] D M6_Spy1625 tRNA pseudouridine synthase A K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12] D M6_Spy0951 tRNA pseudouridine synthase B K03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25] D M6_Spy0647 Cysteine desulfhydrase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D M6_Spy0842 Cysteine desulfhydrase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D M6_Spy0861 Sua5 K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87] D M6_Spy0748 tRNA delta(2)-isopentenylpyrophosphate transferase K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75] D M6_Spy0811 tRNA (5-carboxymethylaminomethyl-2-thiouridylate) synthase K03650 mnmE; tRNA modification GTPase [EC:3.6.-.-] D M6_Spy1856 Putative tRNA (5-carboxymethylaminomethyl-2-thiouridylate) synthase subunit GidA K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme D M6_Spy0238 Ribonuclease P protein component K03536 rnpA; ribonuclease P protein component [EC:3.1.26.5] D M6_Spy1433 Glycyl-tRNA synthetase alpha chain K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14] D M6_Spy1432 Glycyl-tRNA synthetase beta chain K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14] D M6_Spy0234 Glutamyl-tRNA synthetase K09698 gltX; nondiscriminating glutamyl-tRNA synthetase [EC:6.1.1.24] D M6_Spy0519 Transcriptional regulator K03976 ybaK; Cys-tRNA(Pro)/Cys-tRNA(Cys) deacylase [EC:3.1.1.-] D M6_Spy0214 tRNA-specific adenosine deaminase K11991 tadA; tRNA(adenine34) deaminase [EC:3.5.4.33] D M6_Spy0153 tRNA-dihydrouridine synthase K05540 dusB; tRNA-dihydrouridine synthase B [EC:1.-.-.-] D M6_Spy0882 Glucose inhibited division protein A K04094 trmFO; methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74] D M6_Spy0675 tRNA (Guanine-N(1)-)-methyltransferase K00554 trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228] D M6_Spy0757 Hypothetical cytosolic protein K06967 trmK; tRNA (adenine22-N1)-methyltransferase [EC:2.1.1.217] D M6_Spy0338 23S rRNA methyltransferase K03216 trmL; tRNA (cytidine/uridine-2'-O-)-methyltransferase [EC:2.1.1.207] D M6_Spy0325 23S rRNA methyltransferase K03437 spoU; RNA methyltransferase, TrmH family D M6_Spy1857 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase K00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13] D M6_Spy1115 S-adenosylmethionine:tRNA ribosyltransferase-isomerase K07568 queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17] D M6_Spy0550 iron-sulfur cluster-binding protein K18979 queG; epoxyqueuosine reductase [EC:1.17.99.6] D M6_Spy0229 Hypothetical cytosolic protein K09765 queH; epoxyqueuosine reductase [EC:1.17.99.6] D M6_Spy0210 Queuine tRNA-ribosyltransferase K00773 tgt; queuine tRNA-ribosyltransferase [EC:2.4.2.29] D M6_Spy0648 Thiamine biosynthesis protein K03151 thiI; tRNA uracil 4-sulfurtransferase [EC:2.8.1.4] D M6_Spy0011 tRNA(Ile)-lysidine synthetase K04075 tilS; tRNA(Ile)-lysidine synthase [EC:6.3.4.19] D M6_Spy1604 Glycoprotease protein family K14742 tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB D M6_Spy1602 O-sialoglycoprotein endopeptidase K25706 tsaD; tRNA N6-adenosine threonylcarbamoyltransferase [EC:2.3.1.234] D M6_Spy1470 ATP/GTP hydrolase K06925 tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE D M6_Spy0295 Hypothetical cytosolic protein K27343 tmcAL; tRNA(Met) cytidine acetate ligase [EC:6.3.4.-] D M6_Spy0441 Exoribonuclease II K12573 rnr; ribonuclease R [EC:3.1.13.1] D M6_Spy1668 Polyribonucleotide nucleotidyltransferase K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8] C 03012 Translation factors [BR:spa03012] D M6_Spy1457 Translation Initiation Factor 2 K02519 infB; translation initiation factor IF-2 D M6_Spy0636 Translation Initiation Factor 3 K02520 infC; translation initiation factor IF-3 D M6_Spy0775 ABC transporter ATP-binding protein K06158 ABCF3; ATP-binding cassette, subfamily F, member 3 D M6_Spy1780 Protein Translation Elongation Factor Ts K02357 tsf; elongation factor Ts D M6_Spy0529 Protein Translation Elongation Factor Tu K02358 tuf; elongation factor Tu D M6_Spy0264 Translation Elongation Factor G K02355 fusA; elongation factor G D M6_Spy0859 Bacterial Peptide Chain Release Factor 1 K02835 prfA; peptide chain release factor 1 D M6_Spy0405 Ribosome Recycling Factor K02838 frr; ribosome recycling factor D M6_Spy0860 Peptide release factor-glutamine N5-methyltransferase K02493 hemK; release factor glutamine methyltransferase [EC:2.1.1.297] D M6_Spy0005 Peptidyl-tRNA hydrolase K01056 PTH1; peptidyl-tRNA hydrolase, PTH1 family [EC:3.1.1.29] D M6_Spy0115 Translation Initiation Factor 1 K02518 infA; translation initiation factor IF-1 D M6_Spy1536 Translation Elongation Factor P K02356 efp; elongation factor P D M6_Spy0551 Bacterial Peptide Chain Release Factor 2 K02836 prfB; peptide chain release factor 2 D M6_Spy1182 Bacterial Peptide Chain Release Factor 3 K02837 prfC; peptide chain release factor 3 C 03110 Chaperones and folding catalysts [BR:spa03110] D M6_Spy1762 ClpC K03696 clpC; ATP-dependent Clp protease ATP-binding subunit ClpC D M6_Spy1261 ATP-dependent clp protease ATP-binding subunit K03697 clpE; ATP-dependent Clp protease ATP-binding subunit ClpE D M6_Spy0711 ATP-dependent protease ATP-binding subunit K04086 clpL; ATP-dependent Clp protease ATP-binding subunit ClpL D M6_Spy0708 ATP-dependent clp protease ATP-binding subunit K03544 clpX; ATP-dependent Clp protease ATP-binding subunit ClpX D M6_Spy1492 DnaK K04043 dnaK; molecular chaperone DnaK D M6_Spy1760 60 kDa chaperonin GROEL K04077 groEL; chaperonin GroEL [EC:5.6.1.7] D M6_Spy1491 DnaJ K03686 dnaJ; molecular chaperone DnaJ D M6_Spy0154 33 kDa chaperonin K04083 hslO; molecular chaperone Hsp33 D M6_Spy1493 GrpE K03687 GRPE; molecular chaperone GrpE D M6_Spy1761 10 kDa chaperonin GROES K04078 groES; chaperonin GroES D M6_Spy1885 Protease Do K04771 degP; serine protease Do [EC:3.4.21.107] D M6_Spy0013 Cell division protein ftsH K03798 ftsH; cell division protease FtsH [EC:3.4.24.-] D M6_Spy0593 ATP synthase A chain K02108 ATPF0A; F-type H+-transporting ATPase subunit a D M6_Spy0367 Lactocepin K01361 E3.4.21.96; lactocepin [EC:3.4.21.96] D M6_Spy1718 C5A peptidase precursor K08652 C5AP; C5a peptidase [EC:3.4.21.110] D M6_Spy0395 Peptidyl-prolyl cis-trans isomerase K03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8] D M6_Spy1377 Peptidyl-prolyl cis-trans isomerase K03768 PPIB; peptidyl-prolyl cis-trans isomerase B (cyclophilin B) [EC:5.2.1.8] D M6_Spy1108 Peptidyl-prolyl cis-trans isomerase K07533 prsA; foldase protein PrsA [EC:5.2.1.8] D M6_Spy1732 Peptidyl-prolyl cis-trans isomerase K07533 prsA; foldase protein PrsA [EC:5.2.1.8] D M6_Spy1571 Thioredoxin K03671 TXN; thioredoxin C 04131 Membrane trafficking [BR:spa04131] D M6_Spy1335 Alpha-mannosidase K01191 MAN2C1; alpha-mannosidase [EC:3.2.1.24] D M6_Spy0265 Glyceraldehyde 3-phosphate dehydrogenase K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] D M6_Spy1190 Phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] D M6_Spy0975 Pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40] C 04121 Ubiquitin system C 03051 Proteasome C 03032 DNA replication proteins [BR:spa03032] D M6_Spy1143 DNA-cytosine methyltransferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D M6_Spy1160 Type II restriction-modification system methylation subunit K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D M6_Spy1243 DNA-binding protein HU K03530 hupB; DNA-binding protein HU-beta D M6_Spy0001 chromosomal replication initiator protein K02313 dnaA; chromosomal replication initiator protein D M6_Spy1853 Replicative DNA helicase K02314 dnaB; replicative DNA helicase [EC:5.6.2.3] D M6_Spy0616 DNA primase K02316 dnaG; DNA primase [EC:2.7.7.101] D M6_Spy0313 Replicative DNA helicase K03346 dnaB; replication initiation and membrane attachment protein D M6_Spy0314 Primosomal protein K11144 dnaI; primosomal protein DnaI D M6_Spy1566 Phage single-strand DNA binding protein K03111 ssb; single-strand DNA-binding protein D M6_Spy0151 Single-strand DNA binding protein K03111 ssb; single-strand DNA-binding protein D M6_Spy0977 DNA polymerase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] D M6_Spy1680 DNA polymerase III alpha subunit K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7] D M6_Spy0002 DNA polymerase III beta chain K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] D M6_Spy1121 DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] D M6_Spy0357 DNA polymerase III, delta' subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7] D M6_Spy1594 DNA polymerase III, epsilon chain K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D M6_Spy1086 DNA polymerase III subunit gamma/tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] D M6_Spy0879 Ribonuclease HII K03470 rnhB; ribonuclease HII [EC:3.1.26.4] D M6_Spy1576 Ribonuclease HIII K03471 rnhC; ribonuclease HIII [EC:3.1.26.4] D M6_Spy0205 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7] D M6_Spy0590 NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] D M6_Spy0870 DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2] D M6_Spy0573 DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2] D M6_Spy0729 Topoisomerase IV subunit A K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2] D M6_Spy0728 Topoisomerase IV subunit B K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2] D M6_Spy0881 DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1] C 03036 Chromosome and associated proteins [BR:spa03036] D M6_Spy1143 DNA-cytosine methyltransferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D M6_Spy1160 Type II restriction-modification system methylation subunit K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D M6_Spy0472 Ribonuclease III K03685 rnc; ribonuclease III [EC:3.1.26.3] D M6_Spy1243 DNA-binding protein HU K03530 hupB; DNA-binding protein HU-beta D M6_Spy0001 chromosomal replication initiator protein K02313 dnaA; chromosomal replication initiator protein D M6_Spy1280 Non-specific DNA-binding protein K04047 dps; starvation-inducible DNA-binding protein D M6_Spy0473 Chromosome partition protein smc K03529 smc; chromosome segregation protein D M6_Spy0334 ScpA K05896 scpA; segregation and condensation protein A D M6_Spy0335 ScpB K06024 scpB; segregation and condensation protein B D M6_Spy1271 Cell division protein ftsA K03590 ftsA; cell division protein FtsA D M6_Spy0008 DivIC K13052 divIC; cell division protein DivIC D M6_Spy0552 Cell division ATP-binding protein K09812 ftsE; cell division transport system ATP-binding protein D M6_Spy0396 FtsK K03466 ftsK; DNA segregation ATPase FtsK/SpoIIIE, S-DNA-T family D M6_Spy1414 FtsL K03586 ftsL; cell division protein FtsL D M6_Spy1272 Cell division protein ftsQ K03589 ftsQ; cell division protein FtsQ D M6_Spy0527 Cell division protein ftsW K03588 ftsW; cell division protein FtsW D M6_Spy0553 Cell division protein FtsX K09811 ftsX; cell division transport system permease protein D M6_Spy1270 Cell division protein ftsZ K03531 ftsZ; cell division protein FtsZ D M6_Spy0574 Septation ring formation regulator K06286 ezrA; septation ring formation regulator D M6_Spy1265 Cell division initiation protein K04074 divIVA; cell division initiation protein D M6_Spy1268 Hypothetical cytosolic protein K09772 sepF; cell division inhibitor SepF D M6_Spy1886 Chromosome partitioning protein K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein D M6_Spy0729 Topoisomerase IV subunit A K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2] D M6_Spy0728 Topoisomerase IV subunit B K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2] D M6_Spy1856 Putative tRNA (5-carboxymethylaminomethyl-2-thiouridylate) synthase subunit GidA K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme D M6_Spy0306 Methyltransferase K03501 gidB; 16S rRNA (guanine527-N7)-methyltransferase [EC:2.1.1.170] D M6_Spy0882 Glucose inhibited division protein A K04094 trmFO; methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74] D M6_Spy0709 YihA K03978 engB; GTP-binding protein D M6_Spy0561 Hypothetical cytosolic protein K09762 whiA; cell division protein WhiA C 03400 DNA repair and recombination proteins [BR:spa03400] D M6_Spy1257 Deoxyribodipyrimidine photolyase K01669 phr; deoxyribodipyrimidine photo-lyase [EC:4.1.99.3] D M6_Spy0725 Uracil-DNA glycosylase K03648 UNG; uracil-DNA glycosylase [EC:3.2.2.27] D M6_Spy1569 A/G-specific adenine DNA glycosylase K03575 mutY; A/G-specific adenine glycosylase [EC:3.2.2.31] D M6_Spy0756 Endonuclease III K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18] D M6_Spy0763 MutT K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] D M6_Spy1262 MutT K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55] D M6_Spy0230 Deoxyuridine 5'-triphosphate nucleotidohydrolase K01520 dut; dUTP diphosphatase [EC:3.6.1.23] D M6_Spy1800 DNA-3-methyladenine glycosylase K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20] D M6_Spy0434 Formamidopyrimidine-DNA glycosylase K10563 mutM; formamidopyrimidine-DNA glycosylase [EC:3.2.2.23 4.2.99.18] D M6_Spy0365 Exodeoxyribonuclease III K01142 E3.1.11.2; exodeoxyribonuclease III [EC:3.1.11.2] D M6_Spy0753 RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-] D M6_Spy0590 NAD-dependent DNA ligase K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2] D M6_Spy0205 DNA polymerase I K02335 polA; DNA polymerase I [EC:2.7.7.7] D M6_Spy1539 Excinuclease ABC subunit A K03701 uvrA; excinuclease ABC subunit A D M6_Spy1044 Excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B D M6_Spy0808 Excinuclease ABC subunit C K03703 uvrC; excinuclease ABC subunit C D M6_Spy0966 DNA helicase II K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4] D M6_Spy0131 DNA-directed RNA polymerase beta chain K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6] D M6_Spy0132 DNA-directed RNA polymerase beta' chain K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6] D M6_Spy0119 DNA-directed RNA polymerase alpha chain K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6] D M6_Spy1619 DNA-directed RNA polymerase delta chain K03048 rpoE; DNA-directed RNA polymerase subunit delta D M6_Spy1386 DNA-directed RNA polymerase omega chain K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6] D M6_Spy0006 Transcription-repair coupling factor K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4] D M6_Spy1825 MutS K03555 mutS; DNA mismatch repair protein MutS D M6_Spy1573 MutS K07456 mutS2; DNA mismatch repair protein MutS2 D M6_Spy1803 MutL K03572 mutL; DNA mismatch repair protein MutL D M6_Spy1253 Exodeoxyribonuclease VII large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6] D M6_Spy1252 Exodeoxyribonuclease VII small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6] D M6_Spy0977 DNA polymerase III alpha subunit K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7] D M6_Spy1680 DNA polymerase III alpha subunit K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7] D M6_Spy0002 DNA polymerase III beta chain K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7] D M6_Spy1121 DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7] D M6_Spy0357 DNA polymerase III, delta' subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7] D M6_Spy1594 DNA polymerase III, epsilon chain K02342 dnaQ; DNA polymerase III subunit epsilon [EC:2.7.7.7] D M6_Spy1086 DNA polymerase III subunit gamma/tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7] D M6_Spy1566 Phage single-strand DNA binding protein K03111 ssb; single-strand DNA-binding protein D M6_Spy0151 Single-strand DNA binding protein K03111 ssb; single-strand DNA-binding protein D M6_Spy1578 Exodeoxyribonuclease V alpha chain K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5] D M6_Spy1798 RecA K03553 recA; recombination protein RecA D M6_Spy1801 Holliday junction DNA helicase K03550 ruvA; holliday junction DNA helicase RuvA D M6_Spy0084 Holliday junction DNA helicase K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4] D M6_Spy1385 Primosomal protein N' K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4] D M6_Spy0231 RadA K04485 radA; DNA repair protein RadA/Sms D M6_Spy1873 RecF K03629 recF; DNA replication and repair protein RecF D M6_Spy1512 ATP-dependent DNA helicase K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4] D M6_Spy0019 RecO K03584 recO; DNA repair protein RecO (recombination protein O) D M6_Spy1186 RecR K06187 recR; recombination protein RecR D M6_Spy1248 RecN K03631 recN; DNA repair protein RecN (Recombination protein N) D M6_Spy1400 Recombination protein recU K03700 recU; recombination protein U D M6_Spy0612 ATP-dependent nuclease subunit A K16898 addA; ATP-dependent helicase/nuclease subunit A [EC:5.6.2.4 3.1.-.-] D M6_Spy0611 ATP-dependent nuclease subunit B K16899 addB; ATP-dependent helicase/nuclease subunit B [EC:5.6.2.4 3.1.-.-] D M6_Spy0437 ATPase K06915 herA; DNA double-strand break repair helicase HerA and related ATPase D M6_Spy0870 DNA gyrase subunit A K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2] D M6_Spy0573 DNA gyrase subunit B K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2] D M6_Spy0881 DNA topoisomerase I K03168 topA; DNA topoisomerase I [EC:5.6.2.1] D M6_Spy1243 DNA-binding protein HU K03530 hupB; DNA-binding protein HU-beta D M6_Spy1236 RecT protein K07455 recT; recombination protein RecT D M6_Spy1580 DNA polymerase IV K02346 dinB; DNA polymerase IV [EC:2.7.7.7] D M6_Spy1162 ImpB/MucB/SamB family protein K03502 umuC; DNA polymerase V D M6_Spy0903 Phage transcriptional repressor K01356 lexA; repressor LexA [EC:3.4.21.88] D M6_Spy1024 Phage transcriptional repressor K01356 lexA; repressor LexA [EC:3.4.21.88] D M6_Spy0556 ATP-dependent helicase, DinG family K03722 dinG; ATP-dependent DNA helicase DinG [EC:5.6.2.3] D M6_Spy1097 Ribonucleoside-diphosphate reductase alpha chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] D M6_Spy0374 Ribonucleoside-diphosphate reductase alpha chain K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1] D M6_Spy1098 Ribonucleoside-diphosphate reductase beta chain K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] D M6_Spy0372 Ribonucleoside-diphosphate reductase beta chain K00526 E1.17.4.1B; ribonucleoside-diphosphate reductase beta chain [EC:1.17.4.1] D M6_Spy0567 Phosphoesterase, DHH family protein K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3] C 03029 Mitochondrial biogenesis [BR:spa03029] D M6_Spy1457 Translation Initiation Factor 2 K02519 infB; translation initiation factor IF-2 D M6_Spy0636 Translation Initiation Factor 3 K02520 infC; translation initiation factor IF-3 D M6_Spy1780 Protein Translation Elongation Factor Ts K02357 tsf; elongation factor Ts D M6_Spy0529 Protein Translation Elongation Factor Tu K02358 tuf; elongation factor Tu D M6_Spy0264 Translation Elongation Factor G K02355 fusA; elongation factor G D M6_Spy0415 GTP-binding protein era K03595 era; GTPase D M6_Spy0129 Tyrosyl-tRNA synthetase K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1] D M6_Spy0193 Leucyl-tRNA synthetase K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4] D M6_Spy1832 Aspartyl-tRNA synthetase K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12] D M6_Spy1827 Arginyl-tRNA synthetase K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19] D M6_Spy1501 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit A K02433 gatA; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7] D M6_Spy1500 Aspartyl/glutamyl-tRNA(Asn/Gln) amidotransferase subunit B K02434 gatB; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7] D M6_Spy1502 Glutamyl-tRNA(Gln) amidotransferase subunit C K02435 gatC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7] D M6_Spy1566 Phage single-strand DNA binding protein K03111 ssb; single-strand DNA-binding protein D M6_Spy0151 Single-strand DNA binding protein K03111 ssb; single-strand DNA-binding protein D M6_Spy1492 DnaK K04043 dnaK; molecular chaperone DnaK D M6_Spy1493 GrpE K03687 GRPE; molecular chaperone GrpE D M6_Spy1760 60 kDa chaperonin GROEL K04077 groEL; chaperonin GroEL [EC:5.6.1.7] D M6_Spy1761 10 kDa chaperonin GROES K04078 groES; chaperonin GroES D M6_Spy1491 DnaJ K03686 dnaJ; molecular chaperone DnaJ D M6_Spy0647 Cysteine desulfhydrase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D M6_Spy0842 Cysteine desulfhydrase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D M6_Spy0239 60 kDa inner membrane protein YIDC K03217 yidC; YidC/Oxa1 family membrane protein insertase D M6_Spy0323 60 kDa inner membrane protein K03217 yidC; YidC/Oxa1 family membrane protein insertase B B 09183 Protein families: signaling and cellular processes C 02000 Transporters [BR:spa02000] D M6_Spy0227 Multidrug resistance ABC transporter ATP-binding and permease protein K18891 patA; ATP-binding cassette, subfamily B, multidrug efflux pump D M6_Spy0228 Multidrug resistance ABC transporter ATP-binding and permease protein K18892 patB; ATP-binding cassette, subfamily B, multidrug efflux pump D M6_Spy0866 Multidrug resistance ABC transporter ATP-binding and permease protein K18887 efrA; ATP-binding cassette, subfamily B, multidrug efflux pump D M6_Spy0867 Multidrug resistance ABC transporter ATP-binding and permease protein K18888 efrB; ATP-binding cassette, subfamily B, multidrug efflux pump D M6_Spy1638 Lantibiotic transport ATP-binding protein K06147 ABCB-BAC; ATP-binding cassette, subfamily B, bacterial D M6_Spy1517 ABC transporter ATP-binding protein K06148 ABCC-BAC; ATP-binding cassette, subfamily C, bacterial D M6_Spy1518 ABC transporter ATP-binding protein K06148 ABCC-BAC; ATP-binding cassette, subfamily C, bacterial D M6_Spy1165 Macrolide-specific ABC-type efflux carrier K18231 msr; macrolide transport system ATP-binding/permease protein D M6_Spy0692 ABC transporter ATP-binding protein K15738 uup; ABC transport system ATP-binding/permease protein D M6_Spy0806 Iron(III)-binding protein K02012 afuA; iron(III) transport system substrate-binding protein D M6_Spy0827 Spermidine/putrescine-binding protein K11069 potD; spermidine/putrescine transport system substrate-binding protein D M6_Spy0826 PotC K11070 potC; spermidine/putrescine transport system permease protein D M6_Spy0825 PotB K11071 potB; spermidine/putrescine transport system permease protein D M6_Spy0824 PotA K11072 potA; spermidine/putrescine transport system ATP-binding protein [EC:7.6.2.11] D M6_Spy0204 Glycine betaine-binding protein K02001 proW; glycine betaine/proline transport system permease protein D M6_Spy0203 Glycine betaine transport ATP-binding protein K02000 proV; glycine betaine/proline transport system ATP-binding protein [EC:7.6.2.9] D M6_Spy0852 Glycine betaine transport system permease protein K05845 opuC; osmoprotectant transport system substrate-binding protein D M6_Spy0851 Glycine betaine transport ATP-binding protein K05847 opuA; osmoprotectant transport system ATP-binding protein [EC:7.6.2.9] D M6_Spy1690 Multiple sugar transport ATP-binding protein K10112 msmX; multiple sugar transport system ATP-binding protein [EC:7.5.2.-] D M6_Spy1032 Maltose/maltodextrin-binding protein K15770 cycB; arabinogalactan oligomer / maltooligosaccharide transport system substrate-binding protein D M6_Spy1033 MalF K15771 ganP; arabinogalactan oligomer / maltooligosaccharide transport system permease protein D M6_Spy1034 MalG K15772 ganQ; arabinogalactan oligomer / maltooligosaccharide transport system permease protein D M6_Spy1326 Sugar-binding protein K17318 lplA; putative aldouronate transport system substrate-binding protein D M6_Spy1328 Sugar transport system permease protein K17319 lplB; putative aldouronate transport system permease protein D M6_Spy1327 Sugar transport system permease protein K17320 lplC; putative aldouronate transport system permease protein D M6_Spy0931 Nucleoside-binding protein K07335 bmpA; basic membrane protein A and related proteins D M6_Spy0184 Nucleoside-binding protein K07335 bmpA; basic membrane protein A and related proteins D M6_Spy0929 Nucleoside transport system permease protein K23535 nupB; general nucleoside transport system permease protein D M6_Spy0928 Nucleoside transport system permease protein K23536 nupC; general nucleoside transport system permease protein D M6_Spy0930 Nucleoside transport ATP-binding protein K23537 nupA; general nucleoside transport system ATP-binding protein D M6_Spy0244 N-acetylneuraminate-binding protein K02027 ABC.MS.S; multiple sugar transport system substrate-binding protein D M6_Spy0246 N-acetylneuraminate transport system permease protein K02025 ABC.MS.P; multiple sugar transport system permease protein D M6_Spy0247 N-acetylneuraminate transport system permease protein K02026 ABC.MS.P1; multiple sugar transport system permease protein D M6_Spy0945 Phosphate-binding protein K02040 pstS; phosphate transport system substrate-binding protein D M6_Spy0944 Phosphate transport system permease protein pstC K02037 pstC; phosphate transport system permease protein D M6_Spy0943 Phosphate transport system permease protein pstA K02038 pstA; phosphate transport system permease protein D M6_Spy0941 Phosphate transport ATP-binding protein pstB K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1] D M6_Spy0942 Phosphate transport ATP-binding protein pstB K02036 pstB; phosphate transport system ATP-binding protein [EC:7.3.2.1] D M6_Spy1045 Glutamine-binding protein K10036 glnH; glutamine transport system substrate-binding protein D M6_Spy1046 Glutamine transport ATP-binding protein K10038 glnQ; glutamine transport system ATP-binding protein [EC:7.4.2.1] D M6_Spy0723 Cystine-binding protein K02424 tcyA; L-cystine transport system substrate-binding protein D M6_Spy0298 ABC transporter substrate-binding protein K02424 tcyA; L-cystine transport system substrate-binding protein D M6_Spy0724 Cystine transport system permease protein K10009 tcyB; L-cystine transport system permease protein D M6_Spy1409 Amino acid ABC transporter permease protein K10009 tcyB; L-cystine transport system permease protein D M6_Spy1408 Amino acid transport ATP-binding protein K10010 tcyC; L-cystine transport system ATP-binding protein [EC:7.4.2.1] D M6_Spy0613 Arginine-binding protein K23059 artP; arginine/lysine/histidine transporter system substrate-binding protein D M6_Spy1259 Arginine transport system permease protein K17077 artQ; arginine/lysine/histidine transport system permease protein D M6_Spy1258 Amino acid transport ATP-binding protein K23060 artR; arginine/lysine/histidine transport system ATP-binding protein [EC:7.4.2.1] D M6_Spy0299 ABC transporter substrate-binding protein K02073 metQ; D-methionine transport system substrate-binding protein D M6_Spy0301 ABC transporter permease protein K02072 metI; D-methionine transport system permease protein D M6_Spy0300 ABC transporter ATP-binding protein K02071 metN; D-methionine transport system ATP-binding protein D M6_Spy0768 ABC transporter substrate-binding protein K01989 K01989; putative tryptophan/tyrosine transport system substrate-binding protein D M6_Spy0770 ABC transporter permease protein K05832 K05832; putative tryptophan/tyrosine transport system permease protein D M6_Spy0771 ABC transporter ATP-binding protein K05833 K05833; putative tryptophan/tyrosine transport system ATP-binding protein D M6_Spy0268 ABC transporter amino acid-binding protein K17073 lysX1; putative lysine transport system substrate-binding protein D M6_Spy0267 Amino acid transport ATP-binding protein K17076 lysY; putative lysine transport system ATP-binding protein D M6_Spy0280 OppA K15580 oppA; oligopeptide transport system substrate-binding protein D M6_Spy0281 OppB K15581 oppB; oligopeptide transport system permease protein D M6_Spy0282 OppC K15582 oppC; oligopeptide transport system permease protein D M6_Spy0283 OppD K15583 oppD; oligopeptide transport system ATP-binding protein D M6_Spy0284 OppF K10823 oppF; oligopeptide transport system ATP-binding protein D M6_Spy1710 Dipeptide-binding protein K02035 ABC.PE.S; peptide/nickel transport system substrate-binding protein D M6_Spy1711 Dipeptide transport system permease protein dppB K02033 ABC.PE.P; peptide/nickel transport system permease protein D M6_Spy1712 Dipeptide transport system permease protein dppC K02034 ABC.PE.P1; peptide/nickel transport system permease protein D M6_Spy1713 Dipeptide transport ATP-binding protein dppD K02031 ddpD; peptide/nickel transport system ATP-binding protein D M6_Spy1714 Dipeptide transport ATP-binding protein dppF K02032 ddpF; peptide/nickel transport system ATP-binding protein D M6_Spy0349 Ferrichrome-binding protein K25308 fhuD; ferric hydroxamate/heme transport system substrate-binding protein D M6_Spy0348 FhuB K25288 fhuB; ferric hydroxamate/heme transport system permease protein D M6_Spy0347 FhuG K25289 fhuG; ferric hydroxamate/heme transport system permease protein D M6_Spy0350 FhuC K25290 fhuA; ferric hydroxamate/heme transport system ATP-binding protein [EC:7.2.2.16] D M6_Spy1521 Hypothetical protein K25113 htsA; heme transport system substrate-binding protein D M6_Spy1520 Ferrichrome transport system permease protein K25114 htsB; heme transport system permease protein D M6_Spy1519 Ferrichrome transport ATP-binding protein K25115 htsC; heme transport system ATP-binding protein [EC:7.6.2.5] D M6_Spy1522 Putative Fe3+-siderophore transport protein K25120 shr; heme sequestration protein D M6_Spy0563 High-affinity zinc uptake system protein znuA precursor K09815 znuA; zinc transport system substrate-binding protein D M6_Spy1717 laminin binding protein K09815 znuA; zinc transport system substrate-binding protein D M6_Spy0127 High-affinity zinc uptake system membrane protein K09816 znuB; zinc transport system permease protein D M6_Spy0126 High-affinity zinc uptake system ATP-binding protein K09817 znuC; zinc transport system ATP-binding protein [EC:7.2.2.20] D M6_Spy0392 Manganese-binding protein K11704 mtsA; iron/zinc/manganese/copper transport system substrate-binding protein D M6_Spy0394 Manganese transport system membrane protein K11705 mtsC; iron/zinc/manganese/copper transport system permease protein D M6_Spy0393 Manganese transport system ATP-binding protein K11706 mtsB; iron/zinc/manganese/copper transport system ATP-binding protein D M6_Spy0212 BioY K03523 bioY; biotin transport system substrate-specific component D M6_Spy1516 membrane-bound protein K16926 htsT; energy-coupling factor transport system substrate-specific component D M6_Spy0522 Integral membrane protein K16927 cbrT; energy-coupling factor transport system substrate-specific component D M6_Spy1861 Cobalt transport protein cbiQ K16785 ecfT; energy-coupling factor transport system permease protein D M6_Spy1515 Cobalt transport protein K16785 ecfT; energy-coupling factor transport system permease protein D M6_Spy1863 Cobalt transport ATP-binding protein cbiO K16786 ecfA1; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-] D M6_Spy1862 Cobalt transport ATP-binding protein cbiO K16787 ecfA2; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-] D M6_Spy1514 Cobalt transport ATP-binding protein K01552 ecfA; energy-coupling factor transport system ATP-binding protein [EC:7.-.-.-] D M6_Spy0586 SagI K25142 lnrN; linearmycin/streptolysin S transport system permease protein D M6_Spy0585 SagH K25143 lnrM; linearmycin/streptolysin S transport system permease protein D M6_Spy0584 SagG K25144 lnrL; linearmycin/streptolysin S transport system ATP-binding protein D M6_Spy0665 ABC transporter permease protein K24948 yknZ; antimicrobial peptide resistance transport system permease protein D M6_Spy1726 ABC transporter permease protein K24948 yknZ; antimicrobial peptide resistance transport system permease protein D M6_Spy1727 ABC transporter ATP-binding protein K24949 yknY; antimicrobial peptide resistance transport system ATP-binding protein [EC:7.6.2.-] D M6_Spy0664 ABC transporter ATP-binding protein K24949 yknY; antimicrobial peptide resistance transport system ATP-binding protein [EC:7.6.2.-] D M6_Spy0553 Cell division protein FtsX K09811 ftsX; cell division transport system permease protein D M6_Spy0552 Cell division ATP-binding protein K09812 ftsE; cell division transport system ATP-binding protein D M6_Spy0457 ABC transporter permease protein K25154 evrC; viologen exporter family transport system permease protein D M6_Spy0456 Daunorubicin resistance transmembrane protein K25155 evrB; viologen exporter family transport system permease protein D M6_Spy0455 Daunorubicin resistance ATP-binding protein K25156 evrA; viologen exporter family transport system ATP-binding protein D M6_Spy1464 EcsB K25157 ecsB; ABC-2 type transport system permease protein D M6_Spy1465 EcsA K25158 ecsA; ABC-2 type transport system ATP-binding protein D M6_Spy1420 ABC transporter permease protein K01992 ABC-2.P; ABC-2 type transport system permease protein D M6_Spy1510 ABC transporter permease protein K01992 ABC-2.P; ABC-2 type transport system permease protein D M6_Spy0622 Polysaccharide export ABC transporter permease protein K01992 ABC-2.P; ABC-2 type transport system permease protein D M6_Spy1421 ABC transporter ATP-binding protein K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein D M6_Spy0623 Polysaccharide export ATP-binding protein K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein D M6_Spy0979 ABC transporter ATP-binding protein K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein D M6_Spy1511 ABC transporter ATP-binding protein K01990 ABC-2.A; ABC-2 type transport system ATP-binding protein D M6_Spy0608 ABC transporter permease protein K02004 ABC.CD.P; putative ABC transport system permease protein D M6_Spy1636 ABC transporter permease protein K02004 ABC.CD.P; putative ABC transport system permease protein D M6_Spy0955 ABC transporter permease protein K02004 ABC.CD.P; putative ABC transport system permease protein D M6_Spy0609 ABC transporter ATP-binding protein K02003 ABC.CD.A; putative ABC transport system ATP-binding protein D M6_Spy1637 ABC transporter ATP-binding protein K02003 ABC.CD.A; putative ABC transport system ATP-binding protein D M6_Spy0956 ABC transporter ATP-binding protein K02003 ABC.CD.A; putative ABC transport system ATP-binding protein D M6_Spy0273 ABC transporter ATP-binding protein K09013 sufC; Fe-S cluster assembly ATP-binding protein D M6_Spy0091 Na+ driven multidrug efflux pump K26937 dinF; MATE family, multidrug efflux pump D M6_Spy1110 Oxalate/formate antiporter K08177 oxlT; MFS transporter, OFA family, oxalate/formate antiporter D M6_Spy0385 Phosphoglycerate transporter protein K02445 glpT; MFS transporter, OPA family, glycerol-3-phosphate transporter D M6_Spy0438 Multidrug resistance protein B K08161 mdtG; MFS transporter, DHA1 family, multidrug resistance protein D M6_Spy1802 Multidrug resistance protein B K08152 lmrP; MFS transporter, DHA1 family, multidrug resistance protein B D M6_Spy0497 Multidrug resistance protein B K18926 lmrB; MFS transporter, DHA2 family, lincomycin resistance protein D M6_Spy1166 Macrolide-efflux protein K08217 mef; MFS transporter, DHA3 family, macrolide efflux protein D M6_Spy1094 Phosphoenolpyruvate-protein phosphotransferase K08483 ptsI; phosphoenolpyruvate-protein phosphotransferase (PTS system enzyme I) [EC:2.7.3.9] D M6_Spy1095 Phosphocarrier protein HPr K02784 ptsH; phosphocarrier protein HPr D M6_Spy1698 PTS system, glucose-specific IIABC component K20108 malT; maltose PTS system EIICB or EIICBA component [EC:2.7.1.208] D M6_Spy1531 PTS system, sucrose-specific IIABC component K02810 scrA; sucrose PTS system EIIBCA or EIIBC component [EC:2.7.1.211] D M6_Spy0499 PTS system, beta-glucoside-specific IIABC component K02757 bglF; beta-glucoside PTS system EIICBA component [EC:2.7.1.-] D M6_Spy1783 PTS system, trehalose-specific IIBC component K02819 treB; trehalose PTS system EIIBC or EIIBCA component [EC:2.7.1.201] D M6_Spy0681 PTS system, fructose-specific IIABC component K02770 fruA; fructose PTS system EIIBC or EIIC component [EC:2.7.1.202] D M6_Spy0971 PTS system, mannitol-specific IIBC component K02800 mtlA; mannitol PTS system EIICBA or EIICB component [EC:2.7.1.197] D M6_Spy1643 PTS system, lactose-specific IIA component K02786 lacF; lactose PTS system EIIA component [EC:2.7.1.207] D M6_Spy1642 PTS system, lactose-specific IIBC component K02788 lacE; lactose PTS system EIICB component [EC:2.7.1.207] D M6_Spy1050 PTS system, cellobiose-specific IIA component K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205] D M6_Spy1746 PTS system, cellobiose-specific IIA component K02759 celC; cellobiose PTS system EIIA component [EC:2.7.1.196 2.7.1.205] D M6_Spy1051 PTS system, cellobiose-specific IIB component K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205] D M6_Spy1745 PTS system, cellobiose-specific IIB component K02760 celA; cellobiose PTS system EIIB component [EC:2.7.1.196 2.7.1.205] D M6_Spy1048 PTS system, cellobiose-specific IIC component K02761 celB; cellobiose PTS system EIIC component D M6_Spy1744 PTS system, cellobiose-specific IIC component K02761 celB; cellobiose PTS system EIIC component D M6_Spy1450 PTS system, galactose-specific IIA component K20112 gatA; galactose PTS system EIIA component [EC:2.7.1.204] D M6_Spy1449 PTS system, galactose-specific IIB component K20113 gatB; galactose PTS system EIIB component [EC:2.7.1.204] D M6_Spy1448 PTS system, galactose-specific IIC component K20114 gatC; galactose PTS system EIIC component D M6_Spy1473 PTS system, mannose-specific IIAB component K02794 manX; mannose PTS system EIIAB component [EC:2.7.1.191] D M6_Spy0800 PTS system, mannose/fructose family IIA component K02793 manXa; mannose PTS system EIIA component [EC:2.7.1.191] D M6_Spy1474 PTS system, mannose-specific IIC component K02795 manY; mannose PTS system EIIC component D M6_Spy0802 PTS system, mannose/fructose family IIC component K02795 manY; mannose PTS system EIIC component D M6_Spy1475 PTS system, mannose-specific IID component K02796 manZ; mannose PTS system EIID component D M6_Spy0803 PTS system, mannose/fructose family IID component K02796 manZ; mannose PTS system EIID component D M6_Spy0801 PTS system, mannose/fructose family IIB component K19507 gfrB; fructoselysine/glucoselysine PTS system EIIB component [EC:2.7.1.-] D M6_Spy0544 PTS system, N-acetylgalactosamine-specific IIA component K02744 agaF; N-acetylgalactosamine PTS system EIIA component [EC:2.7.1.-] D M6_Spy0542 PTS system, N-acetylgalactosamine-specific IIB component K02745 agaV; N-acetylgalactosamine PTS system EIIB component [EC:2.7.1.-] D M6_Spy0541 PTS system, N-acetylgalactosamine-specific IIC component K02746 agaW; N-acetylgalactosamine PTS system EIIC component D M6_Spy0540 PTS system, N-acetylgalactosamine-specific IID component K02747 agaE; N-acetylgalactosamine PTS system EIID component D M6_Spy0196 PTS system, 3-keto-L-gulonate specific IIA component K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194] D M6_Spy1672 Transcription antiterminator, BglG family K02821 ulaC; ascorbate PTS system EIIA or EIIAB component [EC:2.7.1.194] D M6_Spy0195 PTS system, 3-keto-L-gulonate specific IIB component K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194] D M6_Spy1671 PTS system IIB component K02822 ulaB; ascorbate PTS system EIIB component [EC:2.7.1.194] D M6_Spy1670 Putative transport protein K03475 ulaA; ascorbate PTS system EIIC component D M6_Spy0194 PTS system, 3-keto-L-gulonate specific IIC component K03475 ulaA; ascorbate PTS system EIIC component D M6_Spy0463 Dihydroxyacetone kinase phosphotransfer protein K05881 dhaM; phosphoenolpyruvate---glycerone phosphotransferase subunit DhaM [EC:2.7.1.121] D M6_Spy1427 Glycerol uptake facilitator protein K02440 glpF; glycerol uptake facilitator D M6_Spy1585 Aquaporin K02440 glpF; glycerol uptake facilitator D M6_Spy0464 Glycerol uptake facilitator protein K02440 glpF; glycerol uptake facilitator D M6_Spy0745 Glutathione S-transferase K00799 GST; glutathione S-transferase [EC:2.5.1.18] D M6_Spy1187 Formate transporter K21993 fdhC; formate transporter D M6_Spy0615 Large-conductance mechanosensitive channel K03282 mscL; large conductance mechanosensitive channel D M6_Spy1621 Mechanosensitive ion channel K22044 ybiO; moderate conductance mechanosensitive channel D M6_Spy1563 Magnesium and cobalt transport protein corA K03284 corA; magnesium transporter D M6_Spy0343 Magnesium and cobalt efflux protein K03699 tlyC; magnesium and cobalt exporter, CNNM family D M6_Spy0056 unknown phage protein K21449 ata; trimeric autotransporter adhesin D M6_Spy0672 Cobalt-zinc-cadmium resistance protein K16264 czcD; cobalt-zinc-cadmium efflux system protein D M6_Spy1874 Glucose uptake protein homolog K05340 glcU; glucose uptake protein D M6_Spy0303 Serine/threonine sodium symporter K07862 sstT; serine/threonine transporter D M6_Spy0305 KtrB K03498 trkH; trk/ktr system potassium uptake protein D M6_Spy0304 KtrA K03499 trkA; trk/ktr system potassium uptake protein D M6_Spy0658 Uracil permease K02824 uraA; uracil permease D M6_Spy0855 Xanthine permease K16169 pbuX; xanthine permease D M6_Spy1471 Guanine-hypoxanthine permease K06901 pbuG; adenine/guanine/hypoxanthine permease D M6_Spy0835 Chloride channel protein K03281 clcA; chloride channel protein, CIC family D M6_Spy1099 Chloride channel protein K03281 clcA; chloride channel protein, CIC family D M6_Spy0570 Chloride channel protein K03281 clcA; chloride channel protein, CIC family D M6_Spy1437 Sodium-dependent phosphate transporter K03324 yjbB; phosphate:Na+ symporter D M6_Spy1179 Kup system potassium uptake protein K03549 kup; KUP system potassium uptake protein D M6_Spy0339 Riboflavin transporter K23675 fmnP; riboflavin transporter D M6_Spy0520 Thiamine transporter K16789 thiT; thiamine transporter D M6_Spy1188 Hypothetical protein K16788 niaX; niacin transporter D M6_Spy0527 Cell division protein ftsW K03588 ftsW; cell division protein FtsW D M6_Spy0886 Oxaloacetate decarboxylase beta chain K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1] D M6_Spy0892 Oxaloacetate decarboxylase beta chain K20509 madB; carboxybiotin decarboxylase [EC:7.2.4.1] D M6_Spy0883 Oxaloacetate decarboxylase alpha chain K01571 oadA; oxaloacetate decarboxylase (Na+ extruding) subunit alpha [EC:7.2.4.2] D M6_Spy0898 Oxaloacetate decarboxylase alpha chain K01571 oadA; oxaloacetate decarboxylase (Na+ extruding) subunit alpha [EC:7.2.4.2] D M6_Spy0884 Hypothetical membrane associated protein K01573 oadG; oxaloacetate decarboxylase (Na+ extruding) subunit gamma D M6_Spy0885 Biotin carboxyl carrier protein of oxaloacetate decarboxylase K23351 gcdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma D M6_Spy0891 Biotin carboxyl carrier protein of oxaloacetate decarboxylase K23351 gcdC; glutaconyl-CoA/methylmalonyl-CoA decarboxylase subunit gamma D M6_Spy1305 Cytochrome c-type biogenesis protein K06196 ccdA; cytochrome c-type biogenesis protein D M6_Spy1728 periplasmic component of efflux system K24950 yknX; membrane fusion protein, antimicrobial resistance system D M6_Spy0663 periplasmic component of efflux system K24950 yknX; membrane fusion protein, antimicrobial resistance system D M6_Spy1055 Nicotinamide mononucleotide transporter K03811 pnuC; nicotinamide mononucleotide transporter C 02044 Secretion system [BR:spa02044] D M6_Spy1267 Integral membrane protein K02221 yggT; YggT family protein D M6_Spy1175 COME operon protein 1 K02237 comEA; competence protein ComEA D M6_Spy1537 ComE operon protein 2 K01493 comEB; dCMP deaminase [EC:3.5.4.12] D M6_Spy1122 ComE operon protein 3 K02238 comEC; competence protein ComEC D M6_Spy1174 COME operon protein 3 K02238 comEC; competence protein ComEC D M6_Spy1373 ComF operon protein 1 K02240 comFA; competence protein ComFA D M6_Spy1372 ComF operon protein 3 K02242 comFC; competence protein ComFC D M6_Spy0134 ComG operon protein 1 K02243 comGA; competence protein ComGA D M6_Spy0135 ComG operon protein 2 K02244 comGB; competence protein ComGB D M6_Spy0136 ComG operon protein 3 K02245 comGC; competence protein ComGC D M6_Spy0137 ComG operon protein 4 K02246 comGD; competence protein ComGD D M6_Spy0139 ComG operon protein 6 K02248 comGF; competence protein ComGF D M6_Spy1281 Prepilin peptidase family K02236 comC; leader peptidase (prepilin peptidase) / N-methyltransferase [EC:3.4.23.43 2.1.1.-] D M6_Spy1526 SecA K03070 secA; preprotein translocase subunit SecA [EC:7.4.2.8] D M6_Spy1751 Protein translocase subunit secE K03073 secE; preprotein translocase subunit SecE D M6_Spy0440 Protein translocase subunit secG K03075 secG; preprotein translocase subunit SecG D M6_Spy0113 Protein translocase subunit secY K03076 secY; preprotein translocase subunit SecY D M6_Spy0904 signal recognition particle subunit FFH K03106 SRP54; signal recognition particle subunit SRP54 [EC:3.6.5.4] D M6_Spy0496 Cell division protein ftsY K03110 ftsY; fused signal recognition particle receptor D M6_Spy1685 Protein translocase subunit K03210 yajC; preprotein translocase subunit YajC D M6_Spy0239 60 kDa inner membrane protein YIDC K03217 yidC; YidC/Oxa1 family membrane protein insertase D M6_Spy0323 60 kDa inner membrane protein K03217 yidC; YidC/Oxa1 family membrane protein insertase C 02042 Bacterial toxins [BR:spa02042] D M6_Spy0376 C3 family ADP-ribosyltransferase K11044 spyA; C3 family ADP-ribosyltransferase [EC:2.4.2.-] D M6_Spy0746 putative exfoliative toxin K11041 eta; exfoliative toxin A/B D M6_Spy0188 Streptolysin O K11031 slo; thiol-activated cytolysin D M6_Spy0343 Magnesium and cobalt efflux protein K03699 tlyC; magnesium and cobalt exporter, CNNM family D M6_Spy0578 Streptolysin S precursor K11046 sagA; streptolysin S associated protein D M6_Spy0876 Conserved membrane protein K11068 hlyIII; hemolysin III D M6_Spy0741 SpeA variant K11040 se; staphylococcal enterotoxin D M6_Spy1709 SmeZ K11040 se; staphylococcal enterotoxin D M6_Spy0217 Enterotoxin K11040 se; staphylococcal enterotoxin D M6_Spy1196 SpeC K11040 se; staphylococcal enterotoxin D M6_Spy0985 SpeC variant K11040 se; staphylococcal enterotoxin D M6_Spy1550 Hyaluronoglucosaminidase K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] D M6_Spy1332 Hyaluronoglucosaminidase K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] C 02022 Two-component system [BR:spa02022] D M6_Spy0470 VicK K07652 vicK; two-component system, OmpR family, sensor histidine kinase VicK [EC:2.7.13.3] D M6_Spy0469 VicR K07668 vicR; two-component system, OmpR family, response regulator VicR D M6_Spy0936 CiaH K14982 ciaH; two-component system, OmpR family, sensor histidine kinase CiaH [EC:2.7.13.3] D M6_Spy0937 CiaR K14983 ciaR; two-component system, OmpR family, response regulator CiaR D M6_Spy0311 Transmembrane histidine kinase CsrS K18940 arlS; two-component system, OmpR family, sensor histidine kinase ArlS [EC:2.7.13.3] D M6_Spy0310 Response regulator CsrR K18941 arlR; two-component system, OmpR family, response regulator ArlR D M6_Spy1724 Two component system histidine kinase K18986 ihk; two-component system, OmpR family, sensor kinase Ihk [EC:2.7.13.3] D M6_Spy1725 Two-component response regulator K18987 irr; two-component system, OmpR family, response regulator Irr D M6_Spy1379 Two-component sensor protein yvqE K11617 liaS; two-component system, NarL family, sensor histidine kinase LiaS [EC:2.7.13.3] D M6_Spy1378 Two-component response regulator yvqC K11618 liaR; two-component system, NarL family, response regulator LiaR D M6_Spy1635 Sensory transduction protein kinase K14988 salK; two-component system, NarL family, secretion system sensor histidine kinase SalK D M6_Spy1634 Transcriptional regulatory protein K14989 salR; two-component system, NarL family, secretion system response regulator SalR D M6_Spy0829 DpiB K02476 K02476; two-component system, CitB family, sensor kinase [EC:2.7.13.3] D M6_Spy0828 DpiA K02475 K02475; two-component system, CitB family, response regulator D M6_Spy1336 Sensory transduction protein kinase K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D M6_Spy0235 FasB K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D M6_Spy0236 FasC K07706 agrC; two-component system, LytTR family, sensor histidine kinase AgrC [EC:2.7.13.3] D M6_Spy0237 FasA K07707 agrA; two-component system, LytTR family, response regulator AgrA D M6_Spy1324 Two-component sensor kinase yesM K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3] D M6_Spy1301 Two-component sensor kinase YesM K07718 yesM; two-component system, sensor histidine kinase YesM [EC:2.7.13.3] D M6_Spy1323 Two-component response regulator yesN K07720 yesN; two-component system, response regulator YesN D M6_Spy0805 Two-component response regulator YesN K07720 yesN; two-component system, response regulator YesN D M6_Spy1302 Two-component response regulator YesN K07720 yesN; two-component system, response regulator YesN C 02035 Bacterial motility proteins [BR:spa02035] D M6_Spy0723 Cystine-binding protein K02424 tcyA; L-cystine transport system substrate-binding protein D M6_Spy0298 ABC transporter substrate-binding protein K02424 tcyA; L-cystine transport system substrate-binding protein C 03037 Cilium and associated proteins [BR:spa03037] D M6_Spy1173 LPXTG anchored putative adhesin K16473 IFT20; intraflagellar transport protein 20 C 04812 Cytoskeleton proteins [BR:spa04812] D M6_Spy1270 Cell division protein ftsZ K03531 ftsZ; cell division protein FtsZ D M6_Spy1271 Cell division protein ftsA K03590 ftsA; cell division protein FtsA D M6_Spy1886 Chromosome partitioning protein K03497 parB; ParB family transcriptional regulator, chromosome partitioning protein C 04147 Exosome [BR:spa04147] D M6_Spy0577 Enolase K01689 ENO1_2_3; enolase 1/2/3 [EC:4.2.1.11] D M6_Spy0265 Glyceraldehyde 3-phosphate dehydrogenase K00134 GAPDH; glyceraldehyde 3-phosphate dehydrogenase (phosphorylating) [EC:1.2.1.12] D M6_Spy1610 Phosphoglycerate kinase K00927 PGK; phosphoglycerate kinase [EC:2.7.2.3] D M6_Spy0975 Pyruvate kinase K00873 PK; pyruvate kinase [EC:2.7.1.40] D M6_Spy0395 Peptidyl-prolyl cis-trans isomerase K03767 PPIA; peptidyl-prolyl cis-trans isomerase A (cyclophilin A) [EC:5.2.1.8] D M6_Spy1760 60 kDa chaperonin GROEL K04077 groEL; chaperonin GroEL [EC:5.6.1.7] D M6_Spy1492 DnaK K04043 dnaK; molecular chaperone DnaK D M6_Spy0219 Glucose-6-phosphate isomerase K01810 GPI; glucose-6-phosphate isomerase [EC:5.3.1.9] D M6_Spy1875 Inosine-5'-monophosphate dehydrogenase K00088 IMPDH; IMP dehydrogenase [EC:1.1.1.205] D M6_Spy0529 Protein Translation Elongation Factor Tu K02358 tuf; elongation factor Tu D M6_Spy1466 Bis(5'-nucleosyl)-tetraphosphatase (asymmetrical) K02503 HINT1_2; histidine triad (HIT) family protein [EC:3.9.1.-] D M6_Spy0869 L-lactate dehydrogenase K00016 LDH; L-lactate dehydrogenase [EC:1.1.1.27] D M6_Spy0467 Long-chain-fatty-acid--CoA ligase K01897 ACSL; long-chain acyl-CoA synthetase [EC:6.2.1.3] D M6_Spy0166 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy1390 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy0466 Acetyl-CoA acetyltransferase K00626 ACAT; acetyl-CoA C-acetyltransferase [EC:2.3.1.9] D M6_Spy0114 Adenylate kinase K00939 adk; adenylate kinase [EC:2.7.4.3] D M6_Spy0754 Adenine phosphoribosyltransferase K00759 APRT; adenine phosphoribosyltransferase [EC:2.4.2.7] D M6_Spy1429 Glycerol kinase K00864 glpK; glycerol kinase [EC:2.7.1.30] D M6_Spy1607 Glutamine synthetase K01915 glnA; glutamine synthetase [EC:6.3.1.2] D M6_Spy0076 phosphoribosylaminoimidazolecarboxamide formyltransferase K00602 purH; phosphoribosylaminoimidazolecarboxamide formyltransferase / IMP cyclohydrolase [EC:2.1.2.3 3.5.4.10] D M6_Spy0779 Dihydrolipoamide dehydrogenase K00382 DLD; dihydrolipoyl dehydrogenase [EC:1.8.1.4] D M6_Spy0530 Triosephosphate isomerase K01803 TPI; triosephosphate isomerase (TIM) [EC:5.3.1.1] D M6_Spy1190 Phosphoglycerate mutase K01834 PGAM; 2,3-bisphosphoglycerate-dependent phosphoglycerate mutase [EC:5.4.2.11] C 02048 Prokaryotic defense system [BR:spa02048] D M6_Spy1629 Type I restriction-modification system restriction subunit K01153 hsdR; type I restriction enzyme, R subunit [EC:3.1.21.3] D M6_Spy1630 Type I restriction-modification system specificity subunit K01154 hsdS; type I restriction enzyme, S subunit [EC:3.1.21.3] D M6_Spy1631 Type I restriction-modification system methylation subunit K03427 hsdM; type I restriction enzyme M protein [EC:2.1.1.72] D M6_Spy0141 Adenine-specific methyltransferase K00571 E2.1.1.72; site-specific DNA-methyltransferase (adenine-specific) [EC:2.1.1.72] D M6_Spy1143 DNA-cytosine methyltransferase K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D M6_Spy1160 Type II restriction-modification system methylation subunit K00558 DNMT1; DNA (cytosine-5)-methyltransferase 1 [EC:2.1.1.37] D M6_Spy1146 Phage endonuclease K07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-] D M6_Spy1013 Phage endonuclease K07451 mcrA; 5-methylcytosine-specific restriction enzyme A [EC:3.1.21.-] D M6_Spy0488 Plasmid stabilization system antitoxin protein K07473 dinJ; DNA-damage-inducible protein J D M6_Spy0490 Plasmid stabilization system toxin protein K19092 parE1_3_4; toxin ParE1/3/4 D M6_Spy1270 Cell division protein ftsZ K03531 ftsZ; cell division protein FtsZ D M6_Spy0729 Topoisomerase IV subunit A K02621 parC; topoisomerase IV subunit A [EC:5.6.2.2] D M6_Spy0728 Topoisomerase IV subunit B K02622 parE; topoisomerase IV subunit B [EC:5.6.2.2] D M6_Spy0066 unknown phage protein K19167 abiQ; protein AbiQ D M6_Spy0647 Cysteine desulfhydrase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] D M6_Spy0842 Cysteine desulfhydrase K04487 iscS; cysteine desulfurase [EC:2.8.1.7] C 04030 G protein-coupled receptors C 04050 Cytokine receptors C 04054 Pattern recognition receptors C 03310 Nuclear receptors C 04040 Ion channels [BR:spa04040] C 04031 GTP-binding proteins C 04052 Cytokines and neuropeptides C 04515 Cell adhesion molecules C 04090 CD molecules [BR:spa04090] C 01504 Antimicrobial resistance genes [BR:spa01504] D M6_Spy1165 Macrolide-specific ABC-type efflux carrier K18231 msr; macrolide transport system ATP-binding/permease protein D M6_Spy1166 Macrolide-efflux protein K08217 mef; MFS transporter, DHA3 family, macrolide efflux protein D M6_Spy1496 D-alanyl-D-alanine carboxypeptidase K07260 vanY; zinc D-Ala-D-Ala carboxypeptidase [EC:3.4.17.14] D M6_Spy1043 D-alanine-activating enzyme K03367 dltA; D-alanine--poly(phosphoribitol) ligase subunit 1 [EC:6.1.1.13] D M6_Spy1042 DltB K03739 dltB; membrane protein involved in D-alanine export D M6_Spy1041 D-alanyl carrier protein K14188 dltC; D-alanine--poly(phosphoribitol) ligase subunit 2 [EC:6.1.1.13] D M6_Spy1040 DltD precursor K03740 dltD; D-alanine transfer protein C 00535 Proteoglycans C 00536 Glycosaminoglycan binding proteins [BR:spa00536] D M6_Spy1550 Hyaluronoglucosaminidase K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] D M6_Spy1332 Hyaluronoglucosaminidase K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] C 00537 Glycosylphosphatidylinositol (GPI)-anchored proteins [BR:spa00537] D M6_Spy1550 Hyaluronoglucosaminidase K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] D M6_Spy1332 Hyaluronoglucosaminidase K01197 hya; hyaluronoglucosaminidase [EC:3.2.1.35] D M6_Spy0186 NAD glycohydrolase K18153 nga; NAD+ glycohydrolase [EC:3.2.2.5] C 04091 Lectins C 04990 Domain-containing proteins not elsewhere classified B B 09185 Viral protein families C 03200 Viral proteins C 03210 Viral fusion proteins B B 09184 RNA family C 03100 Non-coding RNAs [BR:spa03100] D M6_Spys1888 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D M6_Spys1965 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D M6_Spys1938 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D M6_Spys1901 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D M6_Spys1957 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D M6_Spys1922 tRNA-Ala K14218 tRNA-Ala; tRNA Ala D M6_Spys1946 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D M6_Spys1971 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D M6_Spys1943 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D M6_Spys1898 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D M6_Spys1911 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D M6_Spys1961 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D M6_Spys1942 tRNA-Arg K14219 tRNA-Arg; tRNA Arg D M6_Spys1969 tRNA-Asn K14220 tRNA-Asn; tRNA Asn D M6_Spys1941 tRNA-Asn K14220 tRNA-Asn; tRNA Asn D M6_Spys1962 tRNA-Asn K14220 tRNA-Asn; tRNA Asn D M6_Spys1892 tRNA-Asp K14221 tRNA-Asp; tRNA Asp D M6_Spys1953 tRNA-Asp K14221 tRNA-Asp; tRNA Asp D M6_Spys1905 tRNA-Asp K14221 tRNA-Asp; tRNA Asp D M6_Spys1968 tRNA-Cys K14222 tRNA-Cys; tRNA Cys D M6_Spys1945 tRNA-Gln K14223 tRNA-Gln; tRNA Gln D M6_Spys1935 tRNA-Gln K14223 tRNA-Gln; tRNA Gln D M6_Spys1928 tRNA-Glu K14224 tRNA-Glu; tRNA Glu D M6_Spys1948 tRNA-Glu K14224 tRNA-Glu; tRNA Glu D M6_Spys1970 tRNA-Glu K14224 tRNA-Glu; tRNA Glu D M6_Spys1918 tRNA-Gly K14225 tRNA-Gly; tRNA Gly D M6_Spys1926 tRNA-Gly K14225 tRNA-Gly; tRNA Gly D M6_Spys1896 tRNA-Gly K14225 tRNA-Gly; tRNA Gly D M6_Spys1909 tRNA-Gly K14225 tRNA-Gly; tRNA Gly D M6_Spys1934 tRNA-His K14226 tRNA-His; tRNA His D M6_Spys1919 tRNA-Ile K14227 tRNA-Ile; tRNA Ile D M6_Spys1927 tRNA-Ile K14227 tRNA-Ile; tRNA Ile D M6_Spys1949 tRNA-Ile K14227 tRNA-Ile; tRNA Ile D M6_Spys1897 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D M6_Spys1910 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D M6_Spys1936 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D M6_Spys1894 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D M6_Spys1907 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D M6_Spys1951 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D M6_Spys1960 tRNA-Leu K14228 tRNA-Leu; tRNA Leu D M6_Spys1893 tRNA-Lys K14229 tRNA-Lys; tRNA Lys D M6_Spys1952 tRNA-Lys K14229 tRNA-Lys; tRNA Lys D M6_Spys1906 tRNA-Lys K14229 tRNA-Lys; tRNA Lys D M6_Spys1967 tRNA-Lys K14229 tRNA-Lys; tRNA Lys D M6_Spys1913 tRNA-Met K14230 tRNA-Met; tRNA Met D M6_Spys1914 tRNA-Met K14230 tRNA-Met; tRNA Met D M6_Spys1916 tRNA-Met K14230 tRNA-Met; tRNA Met D M6_Spys1930 tRNA-Met K14230 tRNA-Met; tRNA Met D M6_Spys1917 tRNA-Phe K14231 tRNA-Phe; tRNA Phe D M6_Spys1931 tRNA-Phe K14231 tRNA-Phe; tRNA Phe D M6_Spys1899 tRNA-Pro K14232 tRNA-Pro; tRNA Pro D M6_Spys1912 tRNA-Pro K14232 tRNA-Pro; tRNA Pro D M6_Spys1915 pseudogene K14233 tRNA-Ser; tRNA Ser D M6_Spys1929 pseudogene K14233 tRNA-Ser; tRNA Ser D M6_Spys1959 tRNA-Ser K14233 tRNA-Ser; tRNA Ser D M6_Spys1920 tRNA-Ser K14233 tRNA-Ser; tRNA Ser D M6_Spys1947 tRNA-Thr K14234 tRNA-Thr; tRNA Thr D M6_Spys1895 tRNA-Thr K14234 tRNA-Thr; tRNA Thr D M6_Spys1908 tRNA-Thr K14234 tRNA-Thr; tRNA Thr D M6_Spys1950 tRNA-Thr K14234 tRNA-Thr; tRNA Thr D M6_Spys1933 tRNA-Trp K14235 tRNA-Trp; tRNA Trp D M6_Spys1932 tRNA-Tyr K14236 tRNA-Tyr; tRNA Tyr D M6_Spys1944 tRNA-Tyr K14236 tRNA-Tyr; tRNA Tyr D M6_Spys1891 tRNA-Val K14237 tRNA-Val; tRNA Val D M6_Spys1925 tRNA-Val K14237 tRNA-Val; tRNA Val D M6_Spys1904 tRNA-Val K14237 tRNA-Val; tRNA Val D M6_Spys1954 tRNA-Val K14237 tRNA-Val; tRNA Val D M6_Spys1887 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D M6_Spys1900 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D M6_Spys1921 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D M6_Spys1937 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D M6_Spys1958 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D M6_Spys1966 16S ribosomal RNA K01977 16SrRNA; 16S ribosomal RNA D M6_Spys1889 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D M6_Spys1902 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D M6_Spys1923 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D M6_Spys1939 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D M6_Spys1956 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D M6_Spys1964 23S ribosomal RNA K01980 23SrRNA; 23S ribosomal RNA D M6_Spys1890 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D M6_Spys1903 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D M6_Spys1924 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D M6_Spys1940 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D M6_Spys1955 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA D M6_Spys1963 5S ribosomal RNA K01985 5SrRNA; 5S ribosomal RNA # A09190 Not Included in Pathway or Brite B B 09191 Unclassified: metabolism C 99980 Enzymes with EC numbers D M6_Spy0545 Gluconate 5-dehydrogenase K00046 idnO; gluconate 5-dehydrogenase [EC:1.1.1.69] D M6_Spy0366 L-lactate oxidase K10530 lctO; L-lactate oxidase [EC:1.1.3.2] D M6_Spy1766 Peroxiredoxin reductase (NAD(P)H) K03387 ahpF; NADH-dependent peroxiredoxin subunit F [EC:1.8.1.-] D M6_Spy0407 Peptide methionine sulfoxide reductase K07304 msrA; peptide-methionine (S)-S-oxide reductase [EC:1.8.4.11] D M6_Spy1303 Peptide methionine sulfoxide reductase K12267 msrAB; peptide methionine sulfoxide reductase msrA/msrB [EC:1.8.4.11 1.8.4.12] D M6_Spy0798 Peptide methionine sulfoxide reductase K07305 msrB; peptide-methionine (R)-S-oxide reductase [EC:1.8.4.12] D M6_Spy1765 Peroxiredoxin K24119 ahpC; NADH-dependent peroxiredoxin subunit C [EC:1.11.1.26] D M6_Spy0676 Thioredoxin reductase K21567 fnr; ferredoxin/flavodoxin---NADP+ reductase [EC:1.18.1.2 1.19.1.1] D M6_Spy0714 Arsenate reductase family protein K00537 arsC; arsenate reductase (glutaredoxin) [EC:1.20.4.1] D M6_Spy1788 Anaerobic ribonucleoside-triphosphate reductase activating protein K04068 nrdG; anaerobic ribonucleoside-triphosphate reductase activating protein [EC:1.97.1.4] D M6_Spy1749 Pyruvate formate-lyase activating enzyme K04069 pflA; pyruvate formate lyase activating enzyme [EC:1.97.1.4] D M6_Spy0344 Pyruvate formate-lyase activating enzyme K04069 pflA; pyruvate formate lyase activating enzyme [EC:1.97.1.4] D M6_Spy1397 Methyltransferase K07444 ypsC; putative N6-adenine-specific DNA methylase [EC:2.1.1.-] D M6_Spy0443 Glutaminyl-peptide cyclotransferase K22757 QCT; glutaminyl-peptide cyclotransferase [EC:2.3.2.5] D M6_Spy0481 Glycosyltransferase K21349 ggs; glucosylglycerate synthase [EC:2.4.1.268] D M6_Spy0508 Prolipoprotein diacylglyceryl transferase K13292 lgt; phosphatidylglycerol---prolipoprotein diacylglyceryl transferase [EC:2.5.1.145] D M6_Spy0856 Iron-sulfur cluster assembly/repair protein K03734 apbE; FAD:protein FMN transferase [EC:2.7.1.180] D M6_Spy1613 Predicted kinase related to hydroxyacetone kinase K07030 fakA; fatty acid kinase [EC:2.7.2.18] D M6_Spy1155 phage-related DNA polymerase K02334 dpo; DNA polymerase bacteriophage-type [EC:2.7.7.7] D M6_Spy0034 phage-related DNA polymerase K02334 dpo; DNA polymerase bacteriophage-type [EC:2.7.7.7] D M6_Spy0786 Hypothetical membrane spanning protein K18672 dacA; diadenylate cyclase [EC:2.7.7.85] D M6_Spy0507 HPR(SER) kinase K06023 hprK; HPr kinase/phosphorylase [EC:2.7.11.- 2.7.4.-] D M6_Spy0773 Acetyl esterase K03930 estA; putative tributyrin esterase [EC:3.1.1.-] D M6_Spy0288 Putative lipase K07015 yqeG; putative phosphatase [EC:3.1.3.-] D M6_Spy1855 Phosphoesterase, DHH family protein K22927 gdpP; cyclic-di-AMP phosphodiesterase [EC:3.1.4.59] D M6_Spy0252 Sec-independent protein translocase protein K03424 tatD; TatD DNase family protein [EC:3.1.21.-] D M6_Spy0253 Ribonuclease M5 K05985 rnmV; ribonuclease M5 [EC:3.1.26.8] D M6_Spy1689 Glucan 1,6-alpha-glucosidase K01215 dexB; glucan 1,6-alpha-glucosidase [EC:3.2.1.70] D M6_Spy0543 Unsaturated glucuronyl hydrolase K18581 ugl; unsaturated chondroitin disaccharide hydrolase [EC:3.2.1.180] D M6_Spy0278 D-alanyl-D-alanine carboxypeptidase K01286 E3.4.16.4; D-alanyl-D-alanine carboxypeptidase [EC:3.4.16.4] D M6_Spy1692 Streptokinase K14745 ska; streptokinase A [EC:3.4.-.-] D M6_Spy1677 Peptide deformylase K01462 PDF; peptide deformylase [EC:3.5.1.88] D M6_Spy0694 Peptide deformylase K01462 PDF; peptide deformylase [EC:3.5.1.88] D M6_Spy1092 Polysaccharide deacetylase family protein K22278 pgdA; peptidoglycan-N-acetylglucosamine deacetylase [EC:3.5.1.104] D M6_Spy0170 Translation initiation inhibitor K09022 ridA; 2-iminobutanoate/2-iminopropanoate deaminase [EC:3.5.99.10] D M6_Spy0410 Myosin-crossreactive antigen K10254 ohyA; oleate hydratase [EC:4.2.1.53] D M6_Spy0782 Hyaluronate lyase precursor K01727 hysA; hyaluronate lyase [EC:4.2.2.1] D M6_Spy0537 Calcium-transporting ATPase K01537 ATP2C; P-type Ca2+ transporter type 2C [EC:7.2.2.10] D M6_Spy1193 Lead, cadmium, zinc and mercury transporting ATPase K01534 zntA; Zn2+/Cd2+-exporting ATPase [EC:7.2.2.12 7.2.2.21] C 99981 Carbohydrate metabolism C 99982 Energy metabolism D M6_Spy0633 Ferredoxin K05337 fer; ferredoxin D M6_Spy0276 IscU K04488 iscU; nitrogen fixation protein NifU and related proteins C 99983 Lipid metabolism D M6_Spy0690 DegV family protein K25232 fakB; fatty acid kinase fatty acid binding subunit D M6_Spy1246 DegV family protein K25232 fakB; fatty acid kinase fatty acid binding subunit C 99984 Nucleotide metabolism D M6_Spy0373 NrdI K03647 nrdI; protein involved in ribonucleotide reduction D M6_Spy1696 NrdI K03647 nrdI; protein involved in ribonucleotide reduction D M6_Spy0603 DNA-entry nuclease K15051 endA; DNA-entry nuclease D M6_Spy0067 Sdn K15051 endA; DNA-entry nuclease D M6_Spy1739 Streptodornase K15051 endA; DNA-entry nuclease D M6_Spy1541 Streptodornase K15051 endA; DNA-entry nuclease D M6_Spy1195 MF2 K15051 endA; DNA-entry nuclease D M6_Spy1339 Sda K15051 endA; DNA-entry nuclease C 99985 Amino acid metabolism D M6_Spy0872 Lactoylglutathione lyase K08234 yaeR; glyoxylase I family protein D M6_Spy1269 Pyridoxal-5'-phosphate family protein K06997 yggS; PLP dependent protein C 99986 Glycan metabolism C 99987 Cofactor metabolism C 99988 Secondary metabolism C 99999 Others B B 09192 Unclassified: genetic information processing C 99973 Transcription D M6_Spy1764 Cold shock protein K03704 cspA; cold shock protein D M6_Spy0949 Arsenate reductase family protein K16509 spxA; regulatory protein spx D M6_Spy1797 Arsenate reductase family protein K16509 spxA; regulatory protein spx D M6_Spy0504 transcription accessory protein K06959 tex; protein Tex C 99974 Translation D M6_Spy1376 S1-type RNA-binding domain K07570 GSP13; general stress protein 13 C 99975 Protein processing D M6_Spy1620 Trigger factor, ppiase K03545 tig; trigger factor D M6_Spy0442 SsrA-binding protein K03664 smpB; SsrA-binding protein D M6_Spy1096 Glutaredoxin K06191 nrdH; glutaredoxin-like protein NrdH D M6_Spy0271 Negative regulator of genetic competence K16511 mecA1_2; adapter protein MecA 1/2 C 99976 Replication and repair D M6_Spy0838 DNA repair protein radC K03630 radC; DNA repair protein RadC D M6_Spy0258 RmuC family protein K09760 rmuC; DNA recombination protein RmuC D M6_Spy1178 Hypothetical protein with endo/excinuclease domain K07461 K07461; putative endonuclease D M6_Spy0880 Smf protein K04096 smf; DNA processing protein D M6_Spy0755 DNA replication protein K02086 dnaD; DNA replication protein D M6_Spy1241 DNA replication protein dnaD K02086 dnaD; DNA replication protein D M6_Spy0041 Phage Terminase Small Subunit K07474 xtmA; phage terminase small subunit D M6_Spy0042 Terminase large subunit K06909 xtmB; phage terminase large subunit D M6_Spy1561 Terminase large subunit K06909 xtmB; phage terminase large subunit D M6_Spy1705 ATPase, AAA family K07478 ycaJ; putative ATPase D M6_Spy1817 Virulence-associated protein E K06919 K06919; putative DNA primase/helicase D M6_Spy0035 virulence-associated protein E K06919 K06919; putative DNA primase/helicase D M6_Spy1151 Phage DNA polymerase K06919 K06919; putative DNA primase/helicase D M6_Spy0014 Transposase K07482 K07482; transposase, IS30 family D M6_Spy0812 Transposase K07482 K07482; transposase, IS30 family D M6_Spy1037 Transposase K07482 K07482; transposase, IS30 family D M6_Spy1078 Transposase K07482 K07482; transposase, IS30 family D M6_Spy1527 Transposase K07482 K07482; transposase, IS30 family D M6_Spy0147 Transposase K07482 K07482; transposase, IS30 family D M6_Spy0403 Transposase K07482 K07482; transposase, IS30 family D M6_Spy0650 Transposase K07482 K07482; transposase, IS30 family D M6_Spy1868 Transposase K07482 K07482; transposase, IS30 family D M6_Spy1881 Transposase K07482 K07482; transposase, IS30 family D M6_Spy1882 Transposase K07482 K07482; transposase, IS30 family D M6_Spy1778 Transposase K07482 K07482; transposase, IS30 family D M6_Spy1059 Transposase K07483 K07483; transposase D M6_Spy1100 Transposase K07483 K07483; transposase D M6_Spy0733 Transposase K07483 K07483; transposase D M6_Spy1060 Transposase K07497 K07497; putative transposase D M6_Spy0734 Transposase K07497 K07497; putative transposase C 99979 Viral proteins C 99998 Others D M6_Spy1591 Hypothetical cytosolic protein K09747 ebfC; nucleoid-associated protein EbfC B B 09193 Unclassified: signaling and cellular processes C 99977 Transport D M6_Spy1405 Amino acid permease K03293 TC.AAT; amino acid transporter, AAT family D M6_Spy0015 Amino acid permease K03294 TC.APA; basic amino acid/polyamine antiporter, APA family D M6_Spy0889 Mg2+/citrate complex secondary transporter K03300 TC.CITMHS; citrate-Mg2+:H+ or citrate-Ca2+:H+ symporter, CitMHS family D M6_Spy0967 Na(+)-linked D-alanine glycine permease K03310 TC.AGCS; alanine or glycine:cation symporter, AGCS family D M6_Spy0302 Branched-chain amino acid transport system carrier protein K03311 TC.LIVCS; branched-chain amino acid:cation transporter, LIVCS family D M6_Spy1598 Nucleoside permease nupC K03317 TC.CNT; concentrative nucleoside transporter, CNT family C 99978 Cell growth D M6_Spy1396 Hypothetical protein K20073 mapZ; mid-cell-anchored protein Z D M6_Spy0240 Jag K06346 jag; spoIIIJ-associated protein D M6_Spy1124 Site-specific recombinase K06400 spoIVCA; site-specific DNA recombinase D M6_Spy1125 Site-specific recombinase K06400 spoIVCA; site-specific DNA recombinase D M6_Spy1168 Site-specific recombinase K06400 spoIVCA; site-specific DNA recombinase C 99993 Cell motility C 99995 Signaling proteins D M6_Spy1276 TypA K06207 typA; GTP-binding protein D M6_Spy0411 PhoH K06217 phoH; phosphate starvation-inducible protein PhoH and related proteins C 99992 Structural proteins D M6_Spy0521 N-acetylmuramoyl-L-alanine amidase K07273 acm; lysozyme C 99994 Others D M6_Spy0940 Phosphate transport system protein K02039 phoU; phosphate transport system protein D M6_Spy0363 Copper homeostasis protein K06201 cutC; copper homeostasis protein B B 09194 Poorly characterized C 99996 General function prediction only D M6_Spy1790 Mvi K03810 mviM; virulence factor D M6_Spy1112 Putative competence protein/transcription factor K06198 coiA; competence protein CoiA D M6_Spy0150 tRNA binding domain protein K06878 K06878; tRNA-binding protein D M6_Spy0517 Hydrolase (HAD superfamily) K07025 K07025; putative hydrolase of the HAD superfamily D M6_Spy0277 ABC transporter-associated protein K09014 sufB; Fe-S cluster assembly protein SufB D M6_Spy0274 ABC transporter-associated protein K09015 sufD; Fe-S cluster assembly protein SufD D M6_Spy1074 Ribonuclease BN K07058 K07058; membrane protein D M6_Spy0743 Rhodanese-related sulfurtransferases K07146 K07146; UPF0176 protein D M6_Spy0307 LemA K03744 lemA; LemA protein D M6_Spy0505 Zinc metalloprotease K03095 sprL; SprT-like protein D M6_Spy1849 Phage infection protein K01421 yhgE; putative membrane protein D M6_Spy1843 Integral membrane protein K08974 K08974; putative membrane protein D M6_Spy0501 Hypothetical membrane spanning protein K08986 ycgQ; putative membrane protein C 99997 Function unknown D M6_Spy0536 dGTP triphosphohydrolase K06885 K06885; uncharacterized protein D M6_Spy1617 Alpha/beta hydrolase K06889 K06889; uncharacterized protein D M6_Spy0327 Integral membrane protein K06890 K06890; uncharacterized protein D M6_Spy0206 CoA binding protein K06929 K06929; uncharacterized protein D M6_Spy0326 Hydrolase (HAD superfamily) K06950 K06950; uncharacterized protein D M6_Spy0668 RNA binding protein K06960 K06960; uncharacterized protein D M6_Spy1659 Hypothetical cytosolic protein K06962 K06962; uncharacterized protein D M6_Spy0588 Endonuclease/Exonuclease/phosphatase family protein K07004 K07004; uncharacterized protein D M6_Spy0671 Hypothetical cytosolic protein K07006 K07006; uncharacterized protein D M6_Spy0677 Hypothetical membrane spanning protein K07035 K07035; uncharacterized protein D M6_Spy0610 Neutral zinc metallopeptidase family K07054 K07054; uncharacterized protein D M6_Spy0502 Hypothetical membrane spanning protein K07089 K07089; uncharacterized protein D M6_Spy0331 putative phosphoesterase K07095 K07095; uncharacterized protein D M6_Spy1189 Transcriptional regulator, biotin repressor family K07105 K07105; uncharacterized protein D M6_Spy0752 Short chain dehydrogenase K07124 K07124; uncharacterized protein D M6_Spy0341 Fe-S oxidoreductase K07139 K07139; uncharacterized protein D M6_Spy0337 Hypothetical cytosolic protein K08998 K08998; uncharacterized protein D M6_Spy1334 Hypothetical protein K09704 K09704; uncharacterized protein D M6_Spy0905 Signal recognition particle associated protein K09787 K09787; uncharacterized protein D M6_Spy0406 S1 RNA binding domain K00243 K00243; uncharacterized protein D M6_Spy1787 YaaA K09861 K09861; uncharacterized protein D M6_Spy1053 outer surface protein K09963 K09963; uncharacterized protein D M6_Spy0328 Hypothetical exported protein K09976 K09976; uncharacterized protein D M6_Spy1204 Phage endopeptidase K01163 K01163; uncharacterized protein D M6_Spy0652 hypothetical ribosome-associated protein K07584 ysxB; uncharacterized protein D M6_Spy1367 Hypothetical cytosolic protein K07586 ygaC; uncharacterized protein D M6_Spy1459 Hypothetical cytosolic protein K07742 ylxR; uncharacterized protein ! #
#[ KO | BRITE | KEGG2 | KEGG ]
#Last updated: May 12, 2024