+C	Peptidoglycan biosynthesis and degradation proteins	KO
#<h2><a href="/kegg/brite.html"><img src="/Fig/bget/kegg3.gif" align="middle" border=0></a>&nbsp; Peptidoglycan Biosynthesis and Degradation Proteins - Staphylococcus aureus 04-02981 (MRSA)</h2>
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A<b>Precursor biosynthesis</b>
B  Transferase/Dehydrogenase
C    SA2981_2040 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase	K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] 
C    SA2981_2064 murZ; UDP-N-acetylglucosamine 1-carboxyvinyltransferase	K00790 murA; UDP-N-acetylglucosamine 1-carboxyvinyltransferase [EC:2.5.1.7] 
C    SA2981_0716 UDP-N-acetylenolpyruvoylglucosamine reductase	K00075 murB; UDP-N-acetylmuramate dehydrogenase [EC:1.3.1.98] 
B  Amino acid ligase
C    SA2981_1698 murC; UDP-N-acetylmuramate--alanine ligase	K01924 murC; UDP-N-acetylmuramate--alanine ligase [EC:6.3.2.8] 
C    SA2981_1141 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase	K01925 murD; UDP-N-acetylmuramoylalanine--D-glutamate ligase [EC:6.3.2.9] 
C    SA2981_0972 murE; UDP-N-acetylmuramoylalanyl-D-glutamate--2,6-diaminopimelate ligase	K05362 murE; UDP-N-acetylmuramoyl-L-alanyl-D-glutamate-L-lysine ligase [EC:6.3.2.7] 
C    SA2981_2024 ddlA; D-alanine--D-alanine ligase	K01921 ddl; D-alanine-D-alanine ligase [EC:6.3.2.4] 
C    SA2981_2200 fmhB; FmhB protein of FemAB family involved in peptidoglycan interpeptide biosynthesis	K11693 femX; peptidoglycan pentaglycine glycine transferase (the first glycine) [EC:2.3.2.16] 
C    SA2981_1328 femA; FemA, factor essential for methicillin resistance / Glycine interpeptide bridge formation	K11694 femA; peptidoglycan pentaglycine glycine transferase (the second and third glycine) [EC:2.3.2.17] 
C    SA2981_1329 femB; FemB, factor involved in methicillin resistance / Glycine interpeptide bridge formation	K11695 femB; peptidoglycan pentaglycine glycine transferase (the fourth and fifth glycine) [EC:2.3.2.18] 
B  Racemase
C    SA2981_2011 alr; Alanine racemase	K01775 alr; alanine racemase [EC:5.1.1.1] 
C    SA2981_1353 Diaminopimelate epimerase	K01775 alr; alanine racemase [EC:5.1.1.1] 
C    SA2981_1106 murI; Glutamate racemase	K01776 murI; glutamate racemase [EC:5.1.1.3] 
B  Carboxypeptidase
B  Glycosyltransferase
C    SA2981_1140 mraY; Phospho-N-acetylmuramoyl-pentapeptide-transferase	K01000 mraY; phospho-N-acetylmuramoyl-pentapeptide-transferase [EC:2.7.8.13] 
C    SA2981_1372 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase	K02563 murG; UDP-N-acetylglucosamine--N-acetylmuramyl-(pentapeptide) pyrophosphoryl-undecaprenol N-acetylglucosamine transferase [EC:2.4.1.227] 
B  Diphosphatase
C    SA2981_0660 bacitracin resistance protein: Undecaprenyl-diphosphatase	K06153 bacA; undecaprenyl-diphosphatase [EC:3.6.1.27] 
C    SA2981_1371 type 2 phosphatidic acid phosphatase family protein	K19302 bcrC; undecaprenyl-diphosphatase [EC:3.6.1.27] 
B  Flippase
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A<b>Peptidoglycan biosynthesis and degradation</b>
B  Glycosyltransferase/DD-Transpeptidase (Class A PBP)
C    SA2981_1406 pbp1; Multimodular transpeptidase-transglycosylase / Penicillin-binding protein 1A/1B (PBP1)	K05366 mrcA; penicillin-binding protein 1A [EC:2.4.99.28 3.4.16.4] 
B  DD-Transpeptidase (Class B PBP)
C    SA2981_0039 mecA; Penicillin-binding protein PBP2a, methicillin resistance determinant MecA, transpeptidase	K02545 mecA; penicillin-binding protein 2 prime [EC:3.4.16.4] 
C    SA2981_1139 ftsI; Cell division protein FtsI (Peptidoglycan synthetase)	K12552 pbpA; penicillin-binding protein 1 [EC:3.4.-.-] 
C    SA2981_1510 ftsI; Cell division protein FtsI [Peptidoglycan synthetase] / Transpeptidase, Penicillin binding protein transpeptidase domain, Penicillin-binding protein 3	K12553 pbp3; penicillin-binding protein 3 [EC:3.4.-.-] 
B  DD-Carboxypeptidase/DD-Endopeptidase (Low molecular weight PBP)
C    SA2981_0618 D-alanyl-D-alanine carboxypeptidase / Penicillin binding protein PBP4	K07258 dacC; serine-type D-Ala-D-Ala carboxypeptidase (penicillin-binding protein 5/6) [EC:3.4.16.4] 
B  Glycosyltransferase
C    SA2981_1688 sgtA; Multimodular transpeptidase-transglycosylase	K12551 sgtA; monofunctional glycosyltransferase [EC:2.4.99.28] 
C    SA2981_1830 Monofunctional biosynthetic peptidoglycan transglycosylase	K04478 sgtB; monofunctional glycosyltransferase [EC:2.4.99.28] 
B  Transpeptidase
B  Carboxypeptidase
B  Endopeptidase
C    SA2981_0213 M23/M37 peptidase domain protein	K21472 lytH; peptidoglycan LD-endopeptidase LytH [EC:3.4.-.-] 
C    SA2981_0276 lytM; Glycyl-glycine endopeptidase lytM precursor	K08259 lytM; lysostaphin [EC:3.4.24.75] 
B  Sortase
C    SA2981_2464 srtA; LPXTG specific sortase A	K07284 srtA; sortase A [EC:3.4.22.70] 
C    SA2981_1091 srtB; NPQTN specific sortase B	K08600 srtB; sortase B [EC:3.4.22.71] 
B  Lytic transglycosylase
B  Amidase
C    SA2981_1590 lytH; LytH protein involved in methicillin resistance / N-acetylmuramoyl-L-alanine amidase domain protein	K01448 amiABC; N-acetylmuramoyl-L-alanine amidase [EC:3.5.1.28] 
B  Structural protein
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#Last updated: January 30, 2024