+E Ubiquitin system KO
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Ubiquitin System - Trypanosoma brucei brucei
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AUbiquitins and ubiquitin-like proteins
B Ubiquitins
C Tb11.01.1680 polyubiquitin, putative K08770 UBC; ubiquitin C
C Tb927.7.3680 ubiquitin/ribosomal protein S27a, putative K02977 RP-S27Ae; ubiquitin-small subunit ribosomal protein S27Ae
C Tb10.70.2170 ubiquitin/ribosomal protein S27a, putative K02977 RP-S27Ae; ubiquitin-small subunit ribosomal protein S27Ae
B Ubiquitin-like proteins (UBLs)
C Tb927.4.2540 ubiquitin, putative K12158 NEDD8; ubiquitin-like protein Nedd8
C Tb927.6.2110 40S ribosomal protein S30, putative K02983 RP-S30e; small subunit ribosomal protein S30e
C Tb927.6.2100 40S ribosomal protein S30, putative K02983 RP-S30e; small subunit ribosomal protein S30e
C Tb927.7.5910 microtubule-associated protein 1A/1B, light chain 3, putative K08341 GABARAP; GABA(A) receptor-associated protein
C Tb927.7.5900 microtubule-associated protein 1A/1B, light chain 3, putative K08341 GABARAP; GABA(A) receptor-associated protein
C Tb927.7.3320 microtubule-associated protein 1A/1B, light chain 3, putative K08341 GABARAP; GABA(A) receptor-associated protein
C Tb927.4.1830 hypothetical protein, conserved K12161 URM1; ubiquitin related modifier 1
C Tb927.8.5380 hypothetical protein, conserved K12162 UFM1; ubiquitin-fold modifier 1
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AUbiquitin-activating enzymes (E1)
B Ubiquitin activating enzyme
C Tb927.8.2640 ubiquitin-activating enzyme E1, putative K03178 UBE1; ubiquitin-activating enzyme E1 [EC:6.2.1.45]
C Tb09.211.3610 ubiquitin-activating enzyme E1, putative K03178 UBE1; ubiquitin-activating enzyme E1 [EC:6.2.1.45]
B UBL-activating enzymes
C Tb11.02.5410 ubiquitin activating enzyme, putative K10684 UBLE1A; ubiquitin-like 1-activating enzyme E1 A [EC:6.2.1.45]
C Tb927.5.3430 ubiquitin-activating enzyme E1, putative K10685 UBLE1B; ubiquitin-like 1-activating enzyme E1 B [EC:6.2.1.45]
C Tb09.160.3210 ubiquitin-activating enzyme E1, putative K10686 UBA3; NEDD8-activating enzyme E1 [EC:6.2.1.64]
C Tb927.2.4020 ubiquitin activating enzyme, putative K04532 NAE1; NEDD8-activating enzyme E1 regulatory subunit
C Tb11.22.0008 molybdopterin synthase sulphurylase protein, putative K11996 MOCS3; adenylyltransferase and sulfurtransferase [EC:2.7.7.80 2.8.1.11]
C Tb09.160.4430 NAD/FAD dependent dehydrogenase, putative K12164 UBA5; ubiquitin-like modifier-activating enzyme 5
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AUbiquitin-conjugating enzymes (E2)
B Ubiquitin-conjugating enzymes
C Tb927.7.2540 ubiquitin-conjugating enzyme E2, putative K10574 UBE2B; ubiquitin-conjugating enzyme E2 B [EC:2.3.2.23]
C Tb927.8.6090 ubiquitin-conjugating enzyme E2, putative K06688 UBE2C; ubiquitin-conjugating enzyme E2 C [EC:2.3.2.23]
C Tb927.5.1000 ubiquitin-conjugating enzyme E2, putative K06689 UBE2D; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]
C Tb927.4.2710 ubiquitin-conjugating enzyme E2, putative K06689 UBE2D; ubiquitin-conjugating enzyme E2 D [EC:2.3.2.23]
C Tb11.01.5510 ubiquitin-conjugating enzyme E2, putative K10576 UBE2H; ubiquitin-conjugating enzyme E2 H [EC:2.3.2.23]
C Tb927.4.3460 ubiquitin-conjugating enzyme E2, putative K04554 UBE2J2; ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23]
C Tb927.4.3190 ubiquitin-conjugating enzyme E2, putative K04554 UBE2J2; ubiquitin-conjugating enzyme E2 J2 [EC:2.3.2.23]
C Tb09.211.0050 ubiquitin-conjugating enzyme E2, putative K10580 UBE2N; ubiquitin-conjugating enzyme E2 N [EC:2.3.2.23]
C Tb11.01.5790 ubiquitin-conjugating enzyme E2, putative K02207 UBE2R; ubiquitin-conjugating enzyme E2 R [EC:2.3.2.23]
C Tb927.2.3720 ubiquitin-conjugating enzyme, putative K10583 UBE2S; ubiquitin-conjugating enzyme E2 S [EC:2.3.2.23]
C Tb927.8.920 ubiquitin-conjugating enzyme E2, putative K10689 PEX4; peroxin-4 [EC:2.3.2.23]
B UBL-conjugating enzymes
C Tb927.2.2460 ubiquitin-conjugating enzyme E2, putative K10577 UBE2I; ubiquitin-conjugating enzyme E2 I
C Tb927.8.6510 ubiquitin-conjugating enzyme E2, putative K10579 UBE2M; ubiquitin-conjugating enzyme E2 M [EC:2.3.2.34]
C Tb927.2.1890 autophagocytosis associated protein, putative K08343 ATG3; ubiquitin-like-conjugating enzyme ATG3
C Tb09.160.4150 hypothetical protein, conserved K12165 UFC1; ufm1-conjugating enzyme 1
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AUbiquitin ligases (E3)
B HECT type E3
C Tb11.01.5930 hypothetical protein, conserved K10590 TRIP12; E3 ubiquitin-protein ligase TRIP12 [EC:2.3.2.26]
C Tb09.211.4210 ubiquitin-protein ligase, putative K10590 TRIP12; E3 ubiquitin-protein ligase TRIP12 [EC:2.3.2.26]
C Tb927.8.1590 ubiquitin-protein ligase, putative K10592 HUWE1; E3 ubiquitin-protein ligase HUWE1 [EC:2.3.2.26]
C Tb10.6k15.0560 ubiquitin-protein ligase, putative K03874 HECT; other hect domain ubiquitin protein ligase E3 [EC:2.3.2.26]
C Tb927.4.770 ubiquitin-protein ligase, putative K03874 HECT; other hect domain ubiquitin protein ligase E3 [EC:2.3.2.26]
C HECT type E3 associated proteins
B U-box type E3
C Tb927.2.5240 hypothetical protein, conserved K10599 PRPF19; pre-mRNA-processing factor 19 [EC:2.3.2.27]
B Single Ring-finger type E3
C BRE1 proteins
C CBL proteins
C SINA (Seven in absentia) proteins
C Ligand of Numb proteins
C March proteins
C MDM2/MDM4 proteins
C NFX1 proteins
D Tb927.7.2050 hypothetical protein, conserved K12236 NFX1; transcriptional repressor NF-X1
C Pellino proteins
C Peripheral membrane proteins
D Tb927.3.2410 peroxisome assembly protein, putative K13346 PEX10; peroxin-10
D Tb10.61.0440 peroxisome assembly protein, putative K13345 PEX12; peroxin-12
D Tb927.3.2340 peroxin-2 K06664 PEX2; peroxin-2
C RBR proteins
C TRAF proteins
C TRIM/RBCC proteins
C UBR box proteins
C ATL proteins
C Other single Ring-finger type E3
D Tb11.02.2670 hypothetical protein, conserved K22377 LTN1; E3 ubiquitin-protein ligase listerin [EC:2.3.2.27]
D Tb927.5.4280 hypothetical protein, conserved K15708 RNF180; E3 ubiquitin-protein ligase RNF180 [EC:2.3.2.27]
D Tb09.160.3780 hypothetical protein, conserved K10601 SYVN1; E3 ubiquitin-protein ligase synoviolin [EC:2.3.2.27]
D Tb927.6.2710 hypothetical protein, conserved K22381 ZNF598; E3 ubiquitin-protein ligase ZNF598 [EC:2.3.2.27]
D Tb927.5.2920 hypothetical protein, conserved K15716 ZSWIM2; E3 ubiquitin-protein ligase ZSWIM2 [EC:2.3.2.27]
B Atypical E3
B UBL E3 ligases
C Tb10.70.6035 hypothetical protein, conserved K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
C Tb11.02.2150 hypothetical protein, conserved K25662 RNF212; E3 SUMO-protein ligase RNF212 [EC:2.3.2.-]
C Tb10.6k15.2450 hypothetical protein, conserved K22755 UFL1; E3 UFM1-protein ligase 1 [EC:2.3.2.-]
B Multi subunit Ring-finger type E3
C SCF complex
D Ring finger protein
E Tb10.70.6035 hypothetical protein, conserved K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adaptor protein
E Tb11.02.3990 S-phase kinase-associated protein, putative K03094 SKP1; S-phase kinase-associated protein 1
D Target recognizing subunit (F-box)
C Cul2 complex
D Ring finger protein
E Tb10.70.6035 hypothetical protein, conserved K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adoptor protein
E Tb11.02.5330 hypothetical protein, conserved K03872 ELOC; elongin-C
D Target recognizing subunit
E Tb927.6.510 GPEET2 procyclin precursor K03871 VHL; von Hippel-Lindau disease tumor supressor
C Cul3 complex
D Ring finger protein
E Tb10.70.6035 hypothetical protein, conserved K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adoptor and target recognizing subunit (BTB)
C Cul4 complex
D Ring finger protein
E Tb10.70.6035 hypothetical protein, conserved K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adoptor protein
D Target recognizing subunit (DCAF)
E Tb11.02.0690 hypothetical protein, conserved K11789 DCAF1; DDB1- and CUL4-associated factor 1 [EC:2.7.11.1]
E Tb09.211.0770 hypothetical protein, conserved K11805 DCAF7; DDB1- and CUL4-associated factor 7
E Tb09.211.2550 hypothetical protein, conserved K11806 DCAF13; DDB1- and CUL4-associated factor 13
C Cul5 complex
D Ring finger protein
D Cullin
D Adoptor protein
E Tb11.02.5330 hypothetical protein, conserved K03872 ELOC; elongin-C
D Target recognizing subunit
C Cul7 complex
D Ring finger protein
E Tb10.70.6035 hypothetical protein, conserved K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adaptor protein
E Tb11.02.3990 S-phase kinase-associated protein, putative K03094 SKP1; S-phase kinase-associated protein 1
D Target recognizing subunit
C Cul8 complex
D Ring finger protein
E Tb10.70.6035 hypothetical protein, conserved K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
D Adaptor protein
D Target recognizing subunit
C Cul9 complex
D Ring finger protein
E Tb10.70.6035 hypothetical protein, conserved K03868 RBX1; E3 ubiquitin-protein ligase RBX1 [EC:2.3.2.32]
D Cullin
C APC/C
D Ring finger protein
E Tb09.211.1655 hypothetical protein, conserved K03358 APC11; anaphase-promoting complex subunit 11
D Cullin
E Tb09.211.2660 hypothetical protein, conserved K03349 APC2; anaphase-promoting complex subunit 2
D Target recognizing subunit
D Other subunits
E Tb927.6.3280 cyclosome subunit 1, putative K03348 APC1; anaphase-promoting complex subunit 1
E Tb927.6.2150 cell division cycle protein 16, putative K03353 APC6; anaphase-promoting complex subunit 6
E TB927.1.3910 hypothetical protein, conserved K03355 APC8; anaphase-promoting complex subunit 8
E Tb10.61.0630 anaphase promoting complex subunit 10-like protein K03357 APC10; anaphase-promoting complex subunit 10
C BRCC complex
D Tb09.160.0580 Mov34/MPN/PAD-1 metallopeptidase, putative K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D Tb11.01.0360 RAD51 protein K04482 RAD51; DNA repair protein RAD51
C KPC complex
C LUBAC complex
C CTLH complex
C ERAD complex
C LMBR1L-GP78-UBAC2 complex
C SLX5-SLX8 complex
C Multi subunit type E3 associated proteins
D Tb11.03.0210 hypothetical protein, conserved K17263 CAND1; cullin-associated NEDD8-dissociated protein 1
D Tb10.70.4110 hypothetical protein, conserved K23344 DDRGK1; DDRGK domain-containing protein 1
D Tb927.3.2310 hypothetical protein, conserved K26163 PACRG; parkin coregulated gene protein
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ADeubiquitinating enzyme (DUB)
B Ubiquitin-specific proteases (UBPs)
C UCH
D Tb11.03.0890 ubiquitin carboxyl-terminal hydrolase, putative K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
D Tb11.02.2800 ubiquitin carboxyl-terminal hydrolase, putative K05610 UCHL5; ubiquitin carboxyl-terminal hydrolase L5 [EC:3.4.19.12]
C UBP/USP
D Tb09.211.4270 ubiquitin carboxyl-terminal hydrolase, putative K11833 USP2; ubiquitin carboxyl-terminal hydrolase 2 [EC:3.4.19.12]
D Tb11.46.0014 ubiquitin carboxyl-terminal hydrolase, putative K11833 USP2; ubiquitin carboxyl-terminal hydrolase 2 [EC:3.4.19.12]
D Tb11.01.7760 ubiquitin carboxyl-terminal hydrolase, putative K11835 USP4_11; ubiquitin carboxyl-terminal hydrolase 4/11 [EC:3.4.19.12]
D Tb927.3.4840 ubiquitin hydrolase, putative K11836 USP5_13; ubiquitin carboxyl-terminal hydrolase 5/13 [EC:3.4.19.12]
D Tb09.211.4910 ubiquitin carboxyl-terminal hydrolase, putative K11838 USP7; ubiquitin carboxyl-terminal hydrolase 7 [EC:3.4.19.12]
D Tb11.01.6080 ubiquitin carboxyl-terminal hydrolase, putative K11841 USP10; ubiquitin carboxyl-terminal hydrolase 10 [EC:3.4.19.12]
D Tb10.70.5540 ubiquitin carboxyl-terminal hydrolase, putative K11842 USP12_46; ubiquitin carboxyl-terminal hydrolase 12/46 [EC:3.4.19.12]
D Tb927.4.3790 ubiquitin carboxyl-terminal hydrolase, putative K11843 USP14; ubiquitin carboxyl-terminal hydrolase 14 [EC:3.4.19.12]
D Tb11.01.4060 ubiquitin carboxyl-terminal hydrolase, putative K11848 USP20_33; ubiquitin carboxyl-terminal hydrolase 20/33 [EC:3.4.19.12]
D Tb927.6.2690 ubiquitin carboxyl-terminal hydrolase, putative K11851 USP30; ubiquitin carboxyl-terminal hydrolase 30 [EC:3.4.19.12]
D Tb927.6.1110 ubiquitin carboxyl-terminal hydrolase, putative K11854 USP35_38; ubiquitin carboxyl-terminal hydrolase 35/38 [EC:3.4.19.12]
D Tb11.02.2940 ubiquitin carboxyl-terminal hydrolase, putative K11855 USP36_42; ubiquitin carboxyl-terminal hydrolase 36/42 [EC:3.4.19.12]
D Tb927.8.5620 ubiquitin carboxyl-terminal hydrolase, putative K11858 USP48; ubiquitin carboxyl-terminal hydrolase 48 [EC:3.4.19.12]
C OTU
D Tb927.5.2700 otubain, putative K09602 OTUB1; ubiquitin thioesterase protein OTUB1 [EC:3.4.19.12]
C MJD
C MINDY
D Tb927.6.4380 hypothetical protein, conserved K01309 MINDY1_2; ubiquitin carboxyl-terminal hydrolase MINDY-1/2 [EC:3.4.19.12]
D Tb09.244.2580 hypothetical protein, conserved K22647 MINDY3_4; ubiquitin carboxyl-terminal hydrolase MINDY-3/4 [EC:3.4.19.12]
C JAMM
D Tb09.160.0580 Mov34/MPN/PAD-1 metallopeptidase, putative K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
D Tb10.70.4510 proteasome regulatory non-ATPase subunit 11 K03030 PSMD14; 26S proteasome regulatory subunit N11
D Tb10.70.4570 proteasome regulatory non-ATPase subunit 11 K03030 PSMD14; 26S proteasome regulatory subunit N11
C PPPDE
C ZUFSP
C BRISC complex
D Tb09.160.0580 Mov34/MPN/PAD-1 metallopeptidase, putative K11864 BRCC3; BRCA1/BRCA2-containing complex subunit 3 [EC:3.4.19.-]
B UBL-specific proteases (ULPs)
C Tb11.03.0890 ubiquitin carboxyl-terminal hydrolase, putative K05609 UCHL3; ubiquitin carboxyl-terminal hydrolase L3 [EC:3.4.19.12]
C COP9 signalosome (CSN) complex
D Tb927.3.2320 COP9 signalosome complex subunit 2, putative K12176 COPS2; COP9 signalosome complex subunit 2
D Tb10.6k15.2770 COP9 signalosome complex subunit, putative K12178 COPS4; COP9 signalosome complex subunit 4
D Tb927.8.5530 Mov34/MPN/PAD-1 metallopeptidase, putative K09613 COPS5; COP9 signalosome complex subunit 5 [EC:3.4.-.-]
D Tb11.03.0710 hypothetical protein, conserved K12180 COPS7; COP9 signalosome complex subunit 7
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: April 5, 2024