+F Repair protein KO
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DNA Repair and Recombination Proteins - Thermoanaerobacterium thermosaccharolyticum M0795
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AEukaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D Thethe_00218 O-6-methylguanine DNA methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E Thethe_02221 3-methyladenine DNA glycosylase/8-oxoguanine DNA glycosylase K03660 OGG1; N-glycosylase/DNA lyase [EC:3.2.2.- 4.2.99.18]
E Thethe_02050 endonuclease III; DNA-(apurinic or apyrimidinic site) lyase K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
D Long Patch-BER factors
E DNA polymerase delta complex
E DNA polymerase epsilon complex
D Short Patch-BER factors
D Other BER factors
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E XPC-HR23B-CETN2 complex
E Cul4-DDB2 complex
E NER4 complex
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase II complex
E Cul4-CSA complex
E Other TCR factor
D TFIIH complex
E Thethe_00773 DNA helicase, Rad3 K10844 ERCC2; DNA excision repair protein ERCC-2 [EC:5.6.2.3]
D RPA (replication factor A)
D Other NER factors
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
D MutL homologs
D DNA polymerase delta complex
D RPA (replication factor A)
D RFC (replication factor C)
D Other MMR factors
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D MRN(MRX) complex
D BRCA1-core complex
D BRCA1-A complex
D BRCA1-B complex
D BRCA1-C complex
D BRCA complex
D RecA family proteins
D Rad52 family proteins
D Rad54 family proteins
D RecQ family DNA helicases
D Bloom's syndrome complex (BTR)
D RPA (replication factor A)
D Protein phosphatase 4
D AP-5 complex
D SMC5-SMC6 complex
D Other HR factors
C NHEJ (non-homologous end-joining)
D DNA-PK complex
D MRX complex
D DNA Ligase 4 complex
D X-family DNA polymerases
D Other NHEJ factors
C FA (Fanconi anemia) pathway
D FA core complex
D FA core complex binding factors
D Bloom's syndrome complex (BTR)
D FANCD2-I complex
D Downstream FA components
D Other FA pathway factors
C Other DSBR factors
D Protein phosphatase 6
D Ubiquitin ligases
D Others
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
C B-family DNA polymerases
C A-family DNA polymerase
C Rad6 epistasis group
C Other TLS factors
B Check point factors
C Rad9-Hus1-Rad1 complex
C HRAD17(Rad24)-RFC complex
C Rad17-Mec3-Ddc1 complex
C FPC (fork protection complex)
C Triple T complex
C BAG6-UBL4A-GET4 complex
C Other check point factors
B Other factors with a suspected DNA repair function
C DNA polymerases
C Nucleases
C Helicases
C PSO4 complex
C Modulation of nucleotide pools
D Thethe_02769 ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D Thethe_01365 deoxyuridine 5'-triphosphate nucleotidohydrolase Dut K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D Thethe_02827 dUTPase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
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AProkaryotic type
B SSBR (single strand breaks repair)
C Direct repair
D Thethe_00218 O-6-methylguanine DNA methyltransferase K00567 ogt; methylated-DNA-[protein]-cysteine S-methyltransferase [EC:2.1.1.63]
C BER (base exicision repair)
D DNA glycosylases
E Thethe_00069 uracil-DNA glycosylase, family 4 K21929 udg; uracil-DNA glycosylase [EC:3.2.2.27]
E Thethe_00074 3-methyladenine DNA glycosylase K01246 tag; DNA-3-methyladenine glycosylase I [EC:3.2.2.20]
E Thethe_02050 endonuclease III; DNA-(apurinic or apyrimidinic site) lyase K10773 NTHL1; endonuclease III [EC:3.2.2.- 4.2.99.18]
D AP endonucleases
E Thethe_00825 apurinic endonuclease APN1 K01151 nfo; deoxyribonuclease IV [EC:3.1.21.2]
D RecJ
E Thethe_01521 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
D DNA ligase
E Thethe_02168 DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D DNA polymerase I
C NER (nucleotide excision repair)
D GGR (global genome repair) factors
E Thethe_00624 excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A
E Thethe_00623 Excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
E Thethe_00628 Excinuclease ABC subunit C K03703 uvrC; excinuclease ABC subunit C
E Thethe_02540 DNA/RNA helicase, superfamily I K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E Thethe_00522 DNA/RNA helicase, superfamily I K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E Thethe_02169 ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E Thethe_02168 DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D TCR (transcription coupled repair) factors
E DNA-directed RNA polymerase complex (RNAP)
F Thethe_00374 DNA-directed RNA polymerase subunit beta K03043 rpoB; DNA-directed RNA polymerase subunit beta [EC:2.7.7.6]
F Thethe_00375 DNA-directed RNA polymerase subunit beta' K03046 rpoC; DNA-directed RNA polymerase subunit beta' [EC:2.7.7.6]
F Thethe_00412 DNA-directed RNA polymerase, alpha subunit K03040 rpoA; DNA-directed RNA polymerase subunit alpha [EC:2.7.7.6]
F Thethe_01496 DNA-directed RNA polymerase subunit omega K03060 rpoZ; DNA-directed RNA polymerase subunit omega [EC:2.7.7.6]
E TRCF (transcription-repair coupling factor)
F Thethe_00183 transcription-repair coupling factor Mfd K03723 mfd; transcription-repair coupling factor (superfamily II helicase) [EC:5.6.2.4]
C MMR (mismatch excision repair)
D Mismatch and loop recognition factors
E Thethe_01333 DNA mismatch repair protein MutS K03555 mutS; DNA mismatch repair protein MutS
E Thethe_01809 MutS2 family protein K07456 mutS2; DNA mismatch repair protein MutS2
D Molecular matchmaker
E Thethe_01334 DNA mismatch repair protein MutL K03572 mutL; DNA mismatch repair protein MutL
D Strand discrimination factor
D DNA exonucleases
E Thethe_01275 Exodeoxyribonuclease VII large subunit K03601 xseA; exodeoxyribonuclease VII large subunit [EC:3.1.11.6]
E Thethe_01276 Exodeoxyribonuclease VII small subunit K03602 xseB; exodeoxyribonuclease VII small subunit [EC:3.1.11.6]
D DNA polymerase III holoenzyme
E Thethe_00746 DNA-directed DNA polymerase III PolC K02337 dnaE; DNA polymerase III subunit alpha [EC:2.7.7.7]
E Thethe_01379 DNA polymerase III, alpha chain K03763 polC; DNA polymerase III subunit alpha, Gram-positive type [EC:2.7.7.7]
E Thethe_00002 DNA polymerase III, beta subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E Thethe_02847 DNA polymerase sliding clamp subunit K02338 dnaN; DNA polymerase III subunit beta [EC:2.7.7.7]
E Thethe_01124 DNA polymerase III, delta subunit K02340 holA; DNA polymerase III subunit delta [EC:2.7.7.7]
E Thethe_00081 DNA polymerase III, delta'' subunit K02341 holB; DNA polymerase III subunit delta' [EC:2.7.7.7]
E Thethe_00042 DNA polymerase III, subunit gamma/tau K02343 dnaX; DNA polymerase III subunit gamma/tau [EC:2.7.7.7]
D DNA ligase
E Thethe_02168 DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
D Other MMR factors
E Thethe_02540 DNA/RNA helicase, superfamily I K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E Thethe_00522 DNA/RNA helicase, superfamily I K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E Thethe_02169 ATP-dependent DNA helicase PcrA K03657 uvrD; ATP-dependent DNA helicase UvrD/PcrA [EC:5.6.2.4]
E Thethe_02845 single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
E Thethe_02754 single stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
B DSBR (double strand breaks repair)
C HR (homologous recombination)
D RecBC pathway proteins
E Thethe_02274 helicase, putative, RecD/TraA family K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E Thethe_02902 ATP-dependent exoDNAse (exonuclease V), alpha subunit/helicase superfamily I member K03581 recD; exodeoxyribonuclease V alpha subunit [EC:3.1.11.5]
E Thethe_01356 protein RecA K03553 recA; recombination protein RecA
E Thethe_01536 Holliday junction DNA helicase subunit RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E Thethe_01535 Holliday junction DNA helicase subunit RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E Thethe_01537 Holliday junction endonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
E Thethe_01494 replication restart DNA helicase PriA K04066 priA; primosomal protein N' (replication factor Y) (superfamily II helicase) [EC:5.6.2.4]
E Thethe_01350 ATPase involved in DNA repair K03546 sbcC; DNA repair protein SbcC/Rad50
E Thethe_01351 Exodeoxyribonuclease I subunit D K03547 sbcD; DNA repair protein SbcD/Mre11
D RecFOR pathway proteins
E Thethe_01356 protein RecA K03553 recA; recombination protein RecA
E Thethe_00350 DNA repair protein RadA K04485 radA; DNA repair protein RadA/Sms
E Thethe_00004 DNA replication and repair protein RecF K03629 recF; DNA replication and repair protein RecF
E Thethe_01477 ATP-dependent DNA helicase RecG K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E Thethe_00923 putative transcriptional regulator with HTH domain K03655 recG; ATP-dependent DNA helicase RecG [EC:5.6.2.4]
E Thethe_01521 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
E Thethe_01153 DNA replication and repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
E Thethe_00044 DNA replication and repair protein RecR K06187 recR; recombination protein RecR
E Thethe_01283 DNA replication and repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
E Thethe_01536 Holliday junction DNA helicase subunit RuvA K03550 ruvA; holliday junction DNA helicase RuvA
E Thethe_01535 Holliday junction DNA helicase subunit RuvB K03551 ruvB; holliday junction DNA helicase RuvB [EC:5.6.2.4]
E Thethe_01537 Holliday junction endonuclease RuvC K01159 ruvC; crossover junction endodeoxyribonuclease RuvC [EC:3.1.21.10]
D AddAB pathway proteins
D Other HR factor
E Thethe_02656 CRISPR-associated endonuclease Cas1 K15342 cas1; CRISP-associated protein Cas1
D Archaeal homologous recombinant proteins
E Thethe_01350 ATPase involved in DNA repair K03546 sbcC; DNA repair protein SbcC/Rad50
E Thethe_01351 Exodeoxyribonuclease I subunit D K03547 sbcD; DNA repair protein SbcD/Mre11
C NHEJ (non-homologous end-joining)
D Two-component NHEJ DNA repair complex
E Thethe_00684 Ku protein K10979 ku; DNA end-binding protein Ku
E Thethe_00683 ATP dependent DNA ligase-like protein,ATP dependent DNA ligase family protein K01971 ligD; bifunctional non-homologous end joining protein LigD [EC:6.5.1.1]
D SHIIR (short-homology-independent illegitimate recombination)
E Facilitator
F Thethe_00009 DNA gyrase, A subunit K02469 gyrA; DNA gyrase subunit A [EC:5.6.2.2]
F Thethe_00008 DNA gyrase, B subunit K02470 gyrB; DNA gyrase subunit B [EC:5.6.2.2]
F Thethe_01427 DNA topoisomerase I, bacterial K03168 topA; DNA topoisomerase I [EC:5.6.2.1]
E Supressor
F Thethe_00256 bacterial nucleoid DNA-binding protein K03530 hupB; DNA-binding protein HU-beta
F Thethe_02837 bacterial nucleoid DNA-binding protein K03530 hupB; DNA-binding protein HU-beta
D SHDIR (short-homology-dependent illegitimate recombination)
E RecET pathway
F Thethe_01521 single-stranded-DNA-specific exonuclease RecJ K07462 recJ; single-stranded-DNA-specific exonuclease [EC:3.1.-.-]
F Thethe_01153 DNA replication and repair protein RecO K03584 recO; DNA repair protein RecO (recombination protein O)
F Thethe_00044 DNA replication and repair protein RecR K06187 recR; recombination protein RecR
F Thethe_02168 DNA ligase, NAD-dependent K01972 E6.5.1.2; DNA ligase (NAD+) [EC:6.5.1.2]
E Facilitator
E Supressor
F Thethe_00624 excinuclease ABC, A subunit K03701 uvrA; excinuclease ABC subunit A
F Thethe_00623 Excinuclease ABC subunit B K03702 uvrB; excinuclease ABC subunit B
B TLS (translesion DNA synthesis) factors
C Y-family DNA polymerases
D Thethe_02500 nucleotidyltransferase/DNA polymerase involved in DNA repair K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
D Thethe_00489 nucleotidyltransferase/DNA polymerase involved in DNA repair K02346 dinB; DNA polymerase IV [EC:2.7.7.7]
C Other SOS response factors
D Thethe_01356 protein RecA K03553 recA; recombination protein RecA
D Thethe_01340 SOS regulatory protein LexA K01356 lexA; repressor LexA [EC:3.4.21.88]
D Thethe_01675 SOS response transcriptional repressor, RecA-mediated autopeptidase K01356 lexA; repressor LexA [EC:3.4.21.88]
D Thethe_01283 DNA replication and repair protein RecN K03631 recN; DNA repair protein RecN (Recombination protein N)
D Thethe_02845 single-stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D Thethe_02754 single stranded DNA-binding protein K03111 ssb; single-strand DNA-binding protein
D Thethe_01355 hypothetical protein K03565 recX; regulatory protein
B Other factors with a suspected DNA repair function
C DNA polymerase
D Thethe_00704 DNA polymerase IV (family X) K02347 polX; DNA polymerase (family X)
C DNA helicases
C Modulation of nucleotide pools
D Thethe_02769 ADP-ribose pyrophosphatase K03574 mutT; 8-oxo-dGTP diphosphatase [EC:3.6.1.55]
D Thethe_01365 deoxyuridine 5'-triphosphate nucleotidohydrolase Dut K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D Thethe_02827 dUTPase K01520 dut; dUTP diphosphatase [EC:3.6.1.23]
D Thethe_00339 ribonucleoside-diphosphate reductase class II K00525 E1.17.4.1A; ribonucleoside-diphosphate reductase alpha chain [EC:1.17.4.1]
C Others
D Thethe_01372 exopolyphosphatase-like enzyme K06881 nrnA; bifunctional oligoribonuclease and PAP phosphatase NrnA [EC:3.1.3.7 3.1.13.3]
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#[ BRITE | KEGG2 | KEGG ]
#Last updated: March 29, 2024