1. Oxidoreductases

 2. Transferases

 3. Hydrolases

 4. Lyases

   4.1  Carbon-carbon lyases

   4.2  Carbon-oxygen lyases

     4.2.1  Hydro-lyases

       4.2.1.1  carbonic anhydrase

       4.2.1.2  fumarate hydratase

       4.2.1.3  aconitate hydratase

       4.2.1.5  arabinonate dehydratase

       4.2.1.6  galactonate dehydratase

       4.2.1.7  altronate dehydratase

       4.2.1.8  mannonate dehydratase

       4.2.1.9  dihydroxy-acid dehydratase

       4.2.1.10  3-dehydroquinate dehydratase

       4.2.1.11  phosphopyruvate hydratase

       4.2.1.12  phosphogluconate dehydratase

       4.2.1.17  enoyl-CoA hydratase

       4.2.1.18  methylglutaconyl-CoA hydratase

       4.2.1.19  imidazoleglycerol-phosphate dehydratase

       4.2.1.20  tryptophan synthase

       4.2.1.22  cystathionine beta-synthase

       4.2.1.24  porphobilinogen synthase

       4.2.1.25  L-arabinonate dehydratase

       4.2.1.27  acetylenecarboxylate hydratase

       4.2.1.28  propanediol dehydratase

       4.2.1.30  glycerol dehydratase

       4.2.1.31  maleate hydratase

       4.2.1.32  L(+)-tartrate dehydratase

       4.2.1.33  3-isopropylmalate dehydratase

       4.2.1.34  (S)-2-methylmalate dehydratase

       4.2.1.35  (R)-2-methylmalate dehydratase

       4.2.1.36  homoaconitate hydratase

       4.2.1.39  gluconate dehydratase

       4.2.1.40  glucarate dehydratase

       4.2.1.41  5-dehydro-4-deoxyglucarate dehydratase

       4.2.1.42  galactarate dehydratase

       4.2.1.43  2-dehydro-3-deoxy-L-arabinonate dehydratase

       4.2.1.44  myo-inosose-2 dehydratase

       4.2.1.45  CDP-glucose 4,6-dehydratase

       4.2.1.46  dTDP-glucose 4,6-dehydratase

       4.2.1.47  GDP-mannose 4,6-dehydratase

       4.2.1.48  D-glutamate cyclase

       4.2.1.49  urocanate hydratase

       4.2.1.50  pyrazolylalanine synthase

       4.2.1.51  prephenate dehydratase

       4.2.1.53  oleate hydratase

       4.2.1.54  lactoyl-CoA dehydratase

       4.2.1.55  3-hydroxybutyryl-CoA dehydratase

       4.2.1.56  itaconyl-CoA hydratase

       4.2.1.57  isohexenylglutaconyl-CoA hydratase

       4.2.1.59  3-hydroxyacyl-[acyl-carrier-protein] dehydratase

       4.2.1.62  5alpha-hydroxysteroid dehydratase

       4.2.1.65  3-cyanoalanine hydratase

       4.2.1.66  cyanide hydratase

       4.2.1.67  D-fuconate dehydratase

       4.2.1.68  L-fuconate dehydratase

       4.2.1.69  cyanamide hydratase

       4.2.1.70  pseudouridylate synthase

       4.2.1.73  protoaphin-aglucone dehydratase (cyclizing)

       4.2.1.74  medium-chain-enoyl-CoA hydratase

       4.2.1.75  uroporphyrinogen-III synthase

       4.2.1.76  UDP-glucose 4,6-dehydratase

       4.2.1.77  trans-L-3-hydroxyproline dehydratase

       4.2.1.79  2-methylcitrate dehydratase

       4.2.1.80  2-oxopent-4-enoate hydratase

       4.2.1.81  D(-)-tartrate dehydratase

       4.2.1.82  xylonate dehydratase

       4.2.1.83  4-oxalomesaconate hydratase

       4.2.1.84  nitrile hydratase

       4.2.1.85  dimethylmaleate hydratase

       4.2.1.87  octopamine dehydratase

       4.2.1.88  synephrine dehydratase

       4.2.1.90  L-rhamnonate dehydratase

       4.2.1.91  arogenate dehydratase

       4.2.1.92  hydroperoxide dehydratase

       4.2.1.93  ATP-dependent NAD(P)H-hydrate dehydratase

       4.2.1.94  scytalone dehydratase

       4.2.1.95  kievitone hydratase

       4.2.1.96  4a-hydroxytetrahydrobiopterin dehydratase

       4.2.1.97  phaseollidin hydratase

       4.2.1.98  16alpha-hydroxyprogesterone dehydratase

       4.2.1.99  2-methylisocitrate dehydratase

       4.2.1.100  cyclohexa-1,5-dienecarbonyl-CoA hydratase

       4.2.1.103  cyclohexyl-isocyanide hydratase

       4.2.1.104  cyanase

       4.2.1.105  2-hydroxyisoflavanone dehydratase

       4.2.1.106  bile-acid 7alpha-dehydratase

       4.2.1.107  3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase

       4.2.1.108  ectoine synthase

       4.2.1.109  methylthioribulose 1-phosphate dehydratase

       4.2.1.110  aldos-2-ulose dehydratase

       4.2.1.111  1,5-anhydro-D-fructose dehydratase

       4.2.1.112  acetylene hydratase

       4.2.1.113  o-succinylbenzoate synthase

       4.2.1.114  methanogen homoaconitase

       4.2.1.115  UDP-N-acetylglucosamine 4,6-dehydratase (configuration-inverting)

       4.2.1.116  3-hydroxypropionyl-CoA dehydratase

       4.2.1.117  2-methylcitrate dehydratase (2-methyl-trans-aconitate forming)

       4.2.1.118  3-dehydroshikimate dehydratase

       4.2.1.119  enoyl-CoA hydratase 2

       4.2.1.120  4-hydroxybutanoyl-CoA dehydratase

       4.2.1.121  colneleate synthase

       4.2.1.122  tryptophan synthase (indole-salvaging)

       4.2.1.123  tetrahymanol synthase

       4.2.1.124  arabidiol synthase

       4.2.1.125  dammarenediol II synthase

       4.2.1.126  N-acetylmuramic acid 6-phosphate etherase

       4.2.1.127  linalool dehydratase

       4.2.1.128  lupan-3beta,20-diol synthase

       4.2.1.129  squalene---hopanol cyclase

       4.2.1.130  D-lactate dehydratase

       4.2.1.131  carotenoid 1,2-hydratase

       4.2.1.132  2-hydroxyhexa-2,4-dienoate hydratase

       4.2.1.133  copal-8-ol diphosphate hydratase

       4.2.1.134  very-long-chain (3R)-3-hydroxyacyl-CoA dehydratase

       4.2.1.135  UDP-N-acetylglucosamine 4,6-dehydratase (configuration-retaining)

       4.2.1.136  ADP-dependent NAD(P)H-hydrate dehydratase

       4.2.1.137  sporulenol synthase

       4.2.1.138  (+)-caryolan-1-ol synthase

       4.2.1.139  pterocarpan synthase

       4.2.1.140  gluconate/galactonate dehydratase

       4.2.1.141  2-dehydro-3-deoxy-D-arabinonate dehydratase

       4.2.1.142  5'-oxoaverantin cyclase

       4.2.1.143  versicolorin B synthase

       4.2.1.144  3-amino-5-hydroxybenzoate synthase

       4.2.1.145  capreomycidine synthase

       4.2.1.146  L-galactonate dehydratase

       4.2.1.147  5,6,7,8-tetrahydromethanopterin hydro-lyase

       4.2.1.148  2-methylfumaryl-CoA hydratase

       4.2.1.149  crotonobetainyl-CoA hydratase

       4.2.1.150  short-chain-enoyl-CoA hydratase

       4.2.1.151  chorismate dehydratase

       4.2.1.152  hydroperoxy icosatetraenoate dehydratase

       4.2.1.153  3-methylfumaryl-CoA hydratase

       4.2.1.154  tetracenomycin F2 cyclase

       4.2.1.155  (methylthio)acryloyl-CoA hydratase

       4.2.1.156  L-talarate dehydratase

       4.2.1.157  (R)-2-hydroxyisocaproyl-CoA dehydratase

       4.2.1.158  galactarate dehydratase (D-threo-forming)

       4.2.1.159  dTDP-4-dehydro-6-deoxy-alpha-D-glucopyranose 2,3-dehydratase

       4.2.1.160  2,5-diamino-6-(5-phospho-D-ribosylamino)pyrimidin-4(3H)-one isomerase/dehydratase

       4.2.1.161  bisanhydrobacterioruberin hydratase

       4.2.1.162  6-deoxy-6-sulfo-D-gluconate dehydratase

       4.2.1.163  2-oxo-hept-4-ene-1,7-dioate hydratase

       4.2.1.164  dTDP-4-dehydro-2,6-dideoxy-D-glucose 3-dehydratase

       4.2.1.165  chlorophyllide a 31-hydratase

       4.2.1.166  phosphinomethylmalate isomerase

       4.2.1.167  (R)-2-hydroxyglutaryl-CoA dehydratase

       4.2.1.168  GDP-4-dehydro-6-deoxy-alpha-D-mannose 3-dehydratase

       4.2.1.169  3-vinyl bacteriochlorophyllide d 31-hydratase

       4.2.1.170  2-(omega-methylthio)alkylmalate dehydratase

       4.2.1.171  cis-L-3-hydroxyproline dehydratase

       4.2.1.172  trans-4-hydroxy-L-proline dehydratase

       4.2.1.173  ent-8alpha-hydroxylabd-13-en-15-yl diphosphate synthase

       4.2.1.174  peregrinol diphosphate synthase

       4.2.1.175  (R)-3-(aryl)lactoyl-CoA dehydratase

       4.2.1.176  L-lyxonate dehydratase

       4.2.1.177  (2S)-3-sulfopropanediol dehydratase

       4.2.1.178  difructose-dianhydride-III synthase

       4.2.1.179  difructose-anhydride-I synthase

       4.2.1.180  (E)-benzylidenesuccinyl-CoA hydratase

       4.2.1.181  3-carboxymethyl-3-hydroxy-acyl-[acp] dehydratase

       4.2.1.182  phosphomevalonate dehydratase

       4.2.1.183  etheroleic acid synthase

     4.2.2  Acting on polysaccharides

     4.2.3  Acting on phosphates

     4.2.99  Other carbon-oxygen lyases

   4.3  Carbon-nitrogen lyases

   4.4  Carbon-sulfur lyases

   4.5  Carbon-halide lyases

   4.6  Phosphorus-oxygen lyases

   4.7  carbon-phosphorus lyases

   4.8  Nitrogen-oxygen lyases

   4.98  ATP-independent chelatases

   4.99  Other lyases

 5. Isomerases

   5.1  Racemases and epimerases

   5.2  cis-trans-Isomerases

   5.3  Intramolecular oxidoreductases

   5.4  Intramolecular transferases

     5.4.1  Transferring acyl groups

     5.4.2  Phosphotransferases (phosphomutases)

     5.4.3  Transferring amino groups

     5.4.4  Transferring hydroxy groups

     5.4.99  Transferring other groups

       5.4.99.1  methylaspartate mutase

       5.4.99.2  methylmalonyl-CoA mutase

       5.4.99.3  2-acetolactate mutase

       5.4.99.4  2-methyleneglutarate mutase

       5.4.99.5  chorismate mutase

       5.4.99.7  lanosterol synthase

       5.4.99.8  cycloartenol synthase

       5.4.99.9  UDP-galactopyranose mutase

       5.4.99.11  isomaltulose synthase

       5.4.99.12  tRNA pseudouridine38-40 synthase

       5.4.99.13  isobutyryl-CoA mutase

       5.4.99.14  4-carboxymethyl-4-methylbutenolide mutase

       5.4.99.15  (1->4)-alpha-D-glucan 1-alpha-D-glucosylmutase

       5.4.99.16  maltose alpha-D-glucosyltransferase

       5.4.99.17  squalene---hopene cyclase

       5.4.99.18  5-(carboxyamino)imidazole ribonucleotide mutase

       5.4.99.19  16S rRNA pseudouridine516 synthase

       5.4.99.20  23S rRNA pseudouridine2457 synthase

       5.4.99.21  23S rRNA pseudouridine2604 synthase

       5.4.99.22  23S rRNA pseudouridine2605 synthase

       5.4.99.23  23S rRNA pseudouridine1911/1915/1917 synthase

       5.4.99.24  23S rRNA pseudouridine955/2504/2580 synthase

       5.4.99.25  tRNA pseudouridine55 synthase

       5.4.99.26  tRNA pseudouridine65 synthase

       5.4.99.27  tRNA pseudouridine13 synthase

       5.4.99.28  tRNA pseudouridine32 synthase

       5.4.99.29  23S rRNA pseudouridine746 synthase

       5.4.99.30  UDP-arabinopyranose mutase

       5.4.99.31  thalianol synthase

       5.4.99.32  protostadienol synthase

       5.4.99.33  cucurbitadienol synthase

       5.4.99.34  germanicol synthase

       5.4.99.35  taraxerol synthase

       5.4.99.36  isomultiflorenol synthase

       5.4.99.37  dammaradiene synthase

       5.4.99.38  camelliol C synthase

       5.4.99.39  beta-amyrin synthase

       5.4.99.40  alpha-amyrin synthase

       5.4.99.41  lupeol synthase

       5.4.99.42  tRNA pseudouridine31 synthase

       5.4.99.43  21S rRNA pseudouridine2819 synthase

       5.4.99.44  mitochondrial tRNA pseudouridine27/28 synthase

       5.4.99.45  tRNA pseudouridine38/39 synthase

       5.4.99.46  shionone synthase

       5.4.99.47  parkeol synthase

       5.4.99.48  achilleol B synthase

       5.4.99.49  glutinol synthase

       5.4.99.50  friedelin synthase

       5.4.99.51  baccharis oxide synthase

       5.4.99.52  alpha-seco-amyrin synthase

       5.4.99.53  marneral synthase

       5.4.99.54  beta-seco-amyrin synthase

       5.4.99.55  delta-amyrin synthase

       5.4.99.56  tirucalladienol synthase

       5.4.99.57  baruol synthase

       5.4.99.58  methylornithine synthase

       5.4.99.59  dTDP-fucopyranose mutase

       5.4.99.60  cobalt-precorrin-8 methylmutase

       5.4.99.61  precorrin-8X methylmutase

       5.4.99.62  D-ribose pyranase

       5.4.99.63  ethylmalonyl-CoA mutase

       5.4.99.64  2-hydroxyisobutanoyl-CoA mutase

       5.4.99.65  pre-alpha-onocerin synthase

       5.4.99.66  alpha-onocerin synthase

       5.4.99.67  4-amino-4-deoxychorismate mutase

   5.5  Intramolecular lyases

   5.6  Isomerases altering macromolecular conformation

   5.99  Other isomerases

 6. Ligases

 7. Translocases