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KO |
 09100 Metabolism
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09120 Genetic Information Processing
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 09130 Environmental Information Processing
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09131 Membrane transport
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09132 Signal transduction
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 02020 Two-component system
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04010 MAPK signaling pathway [PATH:hsa04010]
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04013 MAPK signaling pathway - fly
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04016 MAPK signaling pathway - plant
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04011 MAPK signaling pathway - yeast
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04012 ErbB signaling pathway [PATH:hsa04012]
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04014 Ras signaling pathway [PATH:hsa04014]
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04015 Rap1 signaling pathway [PATH:hsa04015]
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04310 Wnt signaling pathway [PATH:hsa04310]
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04330 Notch signaling pathway [PATH:hsa04330]
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04340 Hedgehog signaling pathway [PATH:hsa04340]
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04341 Hedgehog signaling pathway - fly
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04350 TGF-beta signaling pathway [PATH:hsa04350]
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04390 Hippo signaling pathway [PATH:hsa04390]
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04391 Hippo signaling pathway - fly
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04392 Hippo signaling pathway - multiple species [PATH:hsa04392]
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04370 VEGF signaling pathway [PATH:hsa04370]
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04371 Apelin signaling pathway [PATH:hsa04371]
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04630 JAK-STAT signaling pathway [PATH:hsa04630]
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04064 NF-kappa B signaling pathway [PATH:hsa04064]
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3932 LCK; LCK proto-oncogene, Src family tyrosine kinase
7535 ZAP70; zeta chain of T cell receptor associated protein kinase 70
27040 LAT; linker for activation of T cells
5335 PLCG1; phospholipase C gamma 1
5588 PRKCQ; protein kinase C theta
102723407 IGH; immunoglobulin heavy variable 4-38-2-like
6850 SYK; spleen associated tyrosine kinase
4067 LYN; LYN proto-oncogene, Src family tyrosine kinase
29760 BLNK; B cell linker
695 BTK; Bruton tyrosine kinase
5336 PLCG2; phospholipase C gamma 2
5579 PRKCB; protein kinase C beta
29775 CARD10; caspase recruitment domain family member 10
84433 CARD11; caspase recruitment domain family member 11
79092 CARD14; caspase recruitment domain family member 14
8915 BCL10; BCL10 immune signaling adaptor
10892 MALT1; MALT1 paracaspase
3553 IL1B; interleukin 1 beta
3554 IL1R1; interleukin 1 receptor type 1
4615 MYD88; MYD88 innate immune signal transduction adaptor
3654 IRAK1; interleukin 1 receptor associated kinase 1
51135 IRAK4; interleukin 1 receptor associated kinase 4
7189 TRAF6; TNF receptor associated factor 6
7124 TNF; tumor necrosis factor
7132 TNFRSF1A; TNF receptor superfamily member 1A
8737 RIPK1; receptor interacting serine/threonine kinase 1
8717 TRADD; TNFRSF1A associated via death domain
7186 TRAF2; TNF receptor associated factor 2
7188 TRAF5; TNF receptor associated factor 5
329 BIRC2; baculoviral IAP repeat containing 2
330 BIRC3; baculoviral IAP repeat containing 3
1896 EDA; ectodysplasin A
10913 EDAR; ectodysplasin A receptor
128178 EDARADD; EDAR associated via death domain
1540 CYLD; CYLD lysine 63 deubiquitinase
60401 EDA2R; ectodysplasin A2 receptor
23586 RIGI; RNA sensor RIG-I
7706 TRIM25; tripartite motif containing 25
3929 LBP; lipopolysaccharide binding protein
929 CD14; CD14 molecule
7099 TLR4; toll like receptor 4
23643 LY96; lymphocyte antigen 96
114609 TIRAP; TIR domain containing adaptor protein
353376 TICAM2; TIR domain containing adaptor molecule 2
148022 TICAM1; TIR domain containing adaptor molecule 1
959 CD40LG; CD40 ligand
958 CD40; CD40 molecule
7187 TRAF3; TNF receptor associated factor 3
8600 TNFSF11; TNF superfamily member 11
8792 TNFRSF11A; TNF receptor superfamily member 11a
4049 LTA; lymphotoxin alpha
4050 LTB; lymphotoxin beta
8740 TNFSF14; TNF superfamily member 14
4055 LTBR; lymphotoxin beta receptor
9020 MAP3K14; mitogen-activated protein kinase kinase kinase 14
6885 MAP3K7; mitogen-activated protein kinase kinase kinase 7
10454 TAB1; TGF-beta activated kinase 1 (MAP3K7) binding protein 1
23118 TAB2; TGF-beta activated kinase 1 (MAP3K7) binding protein 2
257397 TAB3; TGF-beta activated kinase 1 (MAP3K7) binding protein 3
10673 TNFSF13B; TNF superfamily member 13b
115650 TNFRSF13C; TNF receptor superfamily member 13C
8517 IKBKG; inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
1147 CHUK; component of inhibitor of nuclear factor kappa B kinase complex
3551 IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
142 PARP1; poly(ADP-ribose) polymerase 1
51588 PIAS4; protein inhibitor of activated STAT 4
7329 UBE2I; ubiquitin conjugating enzyme E2 I
472 ATM; ATM serine/threonine kinase
55367 PIDD1; p53-induced death domain protein 1
23085 ERC1; ELKS/RAB6-interacting/CAST family member 1
4792 NFKBIA; NFKB inhibitor alpha
4790 NFKB1; nuclear factor kappa B subunit 1
5970 RELA; RELA proto-oncogene, NF-kB subunit
10848 PPP1R13L; protein phosphatase 1 regulatory subunit 13 like
8837 CFLAR; CASP8 and FADD like apoptosis regulator
331 XIAP; X-linked inhibitor of apoptosis
598 BCL2L1; BCL2 like 1
596 BCL2; BCL2 apoptosis regulator
1647 GADD45A; growth arrest and DNA damage inducible alpha
4616 GADD45B; growth arrest and DNA damage inducible beta
10912 GADD45G; growth arrest and DNA damage inducible gamma
7185 TRAF1; TNF receptor associated factor 1
597 BCL2A1; BCL2 related protein A1
4791 NFKB2; nuclear factor kappa B subunit 2
3576 CXCL8; C-X-C motif chemokine ligand 8
7128 TNFAIP3; TNF alpha induced protein 3
5743 PTGS2; prostaglandin-endoperoxide synthase 2
6351 CCL4; C-C motif chemokine ligand 4
9560 CCL4L2; C-C motif chemokine ligand 4 like 2
388372 CCL4L1; C-C motif chemokine ligand 4 like 1
2919 CXCL1; C-X-C motif chemokine ligand 1
2920 CXCL2; C-X-C motif chemokine ligand 2
2921 CXCL3; C-X-C motif chemokine ligand 3
7412 VCAM1; vascular cell adhesion molecule 1
5328 PLAU; plasminogen activator, urokinase
1457 CSNK2A1; casein kinase 2 alpha 1
1459 CSNK2A2; casein kinase 2 alpha 2
283106 CSNK2A3; casein kinase 2 alpha 3
1460 CSNK2B; casein kinase 2 beta
5971 RELB; RELB proto-oncogene, NF-kB subunit
6357 CCL13; C-C motif chemokine ligand 13
6363 CCL19; C-C motif chemokine ligand 19
6366 CCL21; C-C motif chemokine ligand 21
6387 CXCL12; C-X-C motif chemokine ligand 12
3383 ICAM1; intercellular adhesion molecule 1
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K05856 LCK; lymphocyte cell-specific protein tyrosine kinase [EC:2.7.10.2]
K07360 ZAP70; tyrosine-protein kinase ZAP-70 [EC:2.7.10.2]
K07362 LAT; linker for activation of T cells family member 1
K01116 PLCG1; phosphatidylinositol phospholipase C, gamma-1 [EC:3.1.4.11]
K18052 PRKCQ; novel protein kinase C theta type [EC:2.7.11.13]
K06856 IGH; immunoglobulin heavy chain
K05855 SYK; spleen tyrosine kinase [EC:2.7.10.2]
K05854 LYN; tyrosine-protein kinase Lyn [EC:2.7.10.2]
K07371 BLNK; B-cell linker protein
K07370 BTK; Bruton agammaglobulinemia tyrosine kinase [EC:2.7.10.2]
K05859 PLCG2; phosphatidylinositol phospholipase C, gamma-2 [EC:3.1.4.11]
K19662 PRKCB; classical protein kinase C beta type [EC:2.7.11.13]
K20912 CARD10; caspase recruitment domain-containing protein 10
K07367 CARD11; caspase recruitment domain-containing protein 11
K20913 CARD14; caspase recruitment domain-containing protein 14
K07368 BCL10; B-cell CLL/lymphoma 10
K07369 MALT1; mucosa-associated lymphoid tissue lymphoma translocation protein 1 [EC:3.4.22.-]
K04519 IL1B; interleukin 1 beta
K04386 IL1R1; interleukin 1 receptor type I
K04729 MYD88; myeloid differentiation primary response protein MyD88
K04730 IRAK1; interleukin-1 receptor-associated kinase 1 [EC:2.7.11.1]
K04733 IRAK4; interleukin-1 receptor-associated kinase 4 [EC:2.7.11.1]
K03175 TRAF6; TNF receptor-associated factor 6 [EC:2.3.2.27]
K03156 TNF; tumor necrosis factor superfamily, member 2
K03158 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A
K02861 RIPK1; receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]
K03171 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
K03173 TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
K09849 TRAF5; TNF receptor-associated factor 5
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K05480 EDA; ectodysplasin-A
K05162 EDAR; tumor necrosis factor receptor superfamily member EDAR
K23324 EDARADD; ectodysplasin-A receptor-associated adapter protein
K08601 CYLD; ubiquitin carboxyl-terminal hydrolase CYLD [EC:3.4.19.12]
K05163 EDA2R; tumor necrosis factor receptor superfamily member 27
K12646 RIGI; ATP-dependent RNA helicase DDX58 [EC:5.6.2.6]
K10652 TRIM25; tripartite motif-containing protein 25 [EC:2.3.2.27]
K05399 LBP; lipopolysaccharide-binding protein
K04391 CD14; monocyte differentiation antigen CD14
K10160 TLR4; toll-like receptor 4
K05400 LY96; lymphocyte antigen 96
K05403 TIRAP; toll-interleukin 1 receptor (TIR) domain-containing adaptor protein
K05409 TIRP; TRIF-related adaptor molecule
K05842 TRIF; toll-like receptor adapter molecule 1
K03161 TNFSF5; tumor necrosis factor ligand superfamily member 5
K03160 TNFRSF5; tumor necrosis factor receptor superfamily member 5
K03174 TRAF3; TNF receptor-associated factor 3
K05473 TNFSF11; tumor necrosis factor ligand superfamily member 11
K05147 TNFRSF11A; tumor necrosis factor receptor superfamily member 11A
K05468 LTA; lymphotoxin alpha (TNF superfamily, member 1)
K03157 LTB; lymphotoxin beta (TNF superfamily, member 3)
K05477 TNFSF14; tumor necrosis factor ligand superfamily member 14
K03159 TNFRSF3; lymphotoxin beta receptor TNFR superfamily member 3
K04466 MAP3K14; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
K04427 MAP3K7; mitogen-activated protein kinase kinase kinase 7 [EC:2.7.11.25]
K04403 MAP3K7IP1; TAK1-binding protein 1
K04404 MAP3K7IP2; TAK1-binding protein 2
K12793 MAP3K7IP3; TAK1-binding protein 3
K05476 TNFSF13B; tumor necrosis factor ligand superfamily member 13B
K05151 TNFRSF13C; tumor necrosis factor receptor superfamily member 13C
K07210 IKBKG; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04467 IKBKA; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
K16065 PIAS4; E3 SUMO-protein ligase PIAS4 [EC:2.3.2.27]
K10577 UBE2I; ubiquitin-conjugating enzyme E2 I
K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
K10130 LRDD; leucine-rich repeats and death domain-containing protein
K16072 ERC1; ELKS/RAB6-interacting/CAST family member 1
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K27356 PPP1R13L; RelA-associated inhibitor
K04724 CFLAR; CASP8 and FADD-like apoptosis regulator
K04725 XIAP; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
K04570 BCL2L1; Bcl-2-like 1 (apoptosis regulator Bcl-X)
K02161 BCL2; apoptosis regulator Bcl-2
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K03172 TRAF1; TNF receptor-associated factor 1
K02162 BCL2A1; hematopoietic Bcl-2-related protein A1
K04469 NFKB2; nuclear factor of kappa light polypeptide gene enhancer in B-cells 2
K10030 IL8; interleukin 8
K11859 TNFAIP3; tumor necrosis factor, alpha-induced protein 3 [EC:3.4.19.12]
K11987 PTGS2; prostaglandin-endoperoxide synthase 2 [EC:1.14.99.1]
K12964 CCL4; C-C motif chemokine 4
K12964 CCL4; C-C motif chemokine 4
K12964 CCL4; C-C motif chemokine 4
K05505 CXCL1_2_3; C-X-C motif chemokine 1/2/3
K05505 CXCL1_2_3; C-X-C motif chemokine 1/2/3
K05505 CXCL1_2_3; C-X-C motif chemokine 1/2/3
K06527 VCAM1; vascular cell adhesion molecule 1
K01348 PLAU; urokinase plasminogen activator [EC:3.4.21.73]
K03097 CSNK2A; casein kinase II subunit alpha [EC:2.7.11.1]
K03097 CSNK2A; casein kinase II subunit alpha [EC:2.7.11.1]
K03097 CSNK2A; casein kinase II subunit alpha [EC:2.7.11.1]
K03115 CSNK2B; casein kinase II subunit beta
K09253 RELB; transcription factor RelB
K16595 CCL13; C-C motif chemokine 13
K05512 CCL19; C-C motif chemokine 19
K16062 CCL21; C-C motif chemokine 21
K10031 CXCL12; C-X-C motif chemokine 12
K06490 ICAM1; intercellular adhesion molecule 1
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04668 TNF signaling pathway [PATH:hsa04668]
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04066 HIF-1 signaling pathway [PATH:hsa04066]
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04068 FoxO signaling pathway [PATH:hsa04068]
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04020 Calcium signaling pathway [PATH:hsa04020]
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04070 Phosphatidylinositol signaling system [PATH:hsa04070]
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04072 Phospholipase D signaling pathway [PATH:hsa04072]
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04071 Sphingolipid signaling pathway [PATH:hsa04071]
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04024 cAMP signaling pathway [PATH:hsa04024]
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04022 cGMP-PKG signaling pathway [PATH:hsa04022]
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04151 PI3K-Akt signaling pathway [PATH:hsa04151]
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04152 AMPK signaling pathway [PATH:hsa04152]
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04150 mTOR signaling pathway [PATH:hsa04150]
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04075 Plant hormone signal transduction
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09133 Signaling molecules and interaction
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09140 Cellular Processes
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09141 Transport and catabolism
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09143 Cell growth and death
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04110 Cell cycle [PATH:hsa04110]
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04111 Cell cycle - yeast
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04112 Cell cycle - Caulobacter
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04113 Meiosis - yeast
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04114 Oocyte meiosis [PATH:hsa04114]
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04210 Apoptosis [PATH:hsa04210]
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8743 TNFSF10; TNF superfamily member 10
8797 TNFRSF10A; TNF receptor superfamily member 10a
8795 TNFRSF10B; TNF receptor superfamily member 10b
356 FASLG; Fas ligand
355 FAS; Fas cell surface death receptor
8772 FADD; Fas associated via death domain
7124 TNF; tumor necrosis factor
7132 TNFRSF1A; TNF receptor superfamily member 1A
8717 TRADD; TNFRSF1A associated via death domain
8837 CFLAR; CASP8 and FADD like apoptosis regulator
841 CASP8; caspase 8
843 CASP10; caspase 10
839 CASP6; caspase 6
836 CASP3; caspase 3
840 CASP7; caspase 7
637 BID; BH3 interacting domain death agonist
581 BAX; BCL2 associated X, apoptosis regulator
578 BAK1; BCL2 antagonist/killer 1
56616 DIABLO; diablo IAP-binding mitochondrial protein
5414 SEPTIN4; septin 4
27429 HTRA2; HtrA serine peptidase 2
54205 CYCS; cytochrome c, somatic
317 APAF1; apoptotic peptidase activating factor 1
842 CASP9; caspase 9
5551 PRF1; perforin 1
3002 GZMB; granzyme B
10376 TUBA1B; tubulin alpha 1b
7277 TUBA4A; tubulin alpha 4a
7278 TUBA3C; tubulin alpha 3c
7846 TUBA1A; tubulin alpha 1a
84790 TUBA1C; tubulin alpha 1c
51807 TUBA8; tubulin alpha 8
112714 TUBA3E; tubulin alpha 3e
113457 TUBA3D; tubulin alpha 3d
79861 TUBAL3; tubulin alpha like 3
4170 MCL1; MCL1 apoptosis regulator, BCL2 family member
71 ACTG1; actin gamma 1
60 ACTB; actin beta
6709 SPTAN1; spectrin alpha, non-erythrocytic 1
4000 LMNA; lamin A/C
4001 LMNB1; lamin B1
84823 LMNB2; lamin B2
142 PARP1; poly(ADP-ribose) polymerase 1
10038 PARP2; poly(ADP-ribose) polymerase 2
10039 PARP3; poly(ADP-ribose) polymerase family member 3
143 PARP4; poly(ADP-ribose) polymerase family member 4
1676 DFFA; DNA fragmentation factor subunit alpha
1677 DFFB; DNA fragmentation factor subunit beta
2021 ENDOG; endonuclease G
9131 AIFM1; apoptosis inducing factor mitochondria associated 1
2081 ERN1; endoplasmic reticulum to nucleus signaling 1
7186 TRAF2; TNF receptor associated factor 2
3708 ITPR1; inositol 1,4,5-trisphosphate receptor type 1
3709 ITPR2; inositol 1,4,5-trisphosphate receptor type 2
3710 ITPR3; inositol 1,4,5-trisphosphate receptor type 3
823 CAPN1; calpain 1
824 CAPN2; calpain 2
100506742 CASP12; caspase 12 (gene/pseudogene)
9451 EIF2AK3; eukaryotic translation initiation factor 2 alpha kinase 3
1965 EIF2S1; eukaryotic translation initiation factor 2 subunit alpha
468 ATF4; activating transcription factor 4
1649 DDIT3; DNA damage inducible transcript 3
1508 CTSB; cathepsin B
1075 CTSC; cathepsin C
1509 CTSD; cathepsin D
8722 CTSF; cathepsin F
1512 CTSH; cathepsin H
1513 CTSK; cathepsin K
1514 CTSL; cathepsin L
1519 CTSO; cathepsin O
1520 CTSS; cathepsin S
1515 CTSV; cathepsin V
1521 CTSW; cathepsin W
1522 CTSZ; cathepsin Z
329 BIRC2; baculoviral IAP repeat containing 2
330 BIRC3; baculoviral IAP repeat containing 3
331 XIAP; X-linked inhibitor of apoptosis
332 BIRC5; baculoviral IAP repeat containing 5
10018 BCL2L11; BCL2 like 11
598 BCL2L1; BCL2 like 1
596 BCL2; BCL2 apoptosis regulator
1616 DAXX; death domain associated protein
8737 RIPK1; receptor interacting serine/threonine kinase 1
153090 DAB2IP; DAB2 interacting protein
4217 MAP3K5; mitogen-activated protein kinase kinase kinase 5
5599 MAPK8; mitogen-activated protein kinase 8
5602 MAPK10; mitogen-activated protein kinase 10
5601 MAPK9; mitogen-activated protein kinase 9
572 BAD; BCL2 associated agonist of cell death
3725 JUN; Jun proto-oncogene, AP-1 transcription factor subunit
2353 FOS; Fos proto-oncogene, AP-1 transcription factor subunit
7157 TP53; tumor protein p53
8739 HRK; harakiri, BCL2 interacting protein
9020 MAP3K14; mitogen-activated protein kinase kinase kinase 14
1147 CHUK; component of inhibitor of nuclear factor kappa B kinase complex
3551 IKBKB; inhibitor of nuclear factor kappa B kinase subunit beta
8517 IKBKG; inhibitor of nuclear factor kappa B kinase regulatory subunit gamma
4792 NFKBIA; NFKB inhibitor alpha
4790 NFKB1; nuclear factor kappa B subunit 1
5970 RELA; RELA proto-oncogene, NF-kB subunit
5783 PTPN13; protein tyrosine phosphatase non-receptor type 13
1647 GADD45A; growth arrest and DNA damage inducible alpha
4616 GADD45B; growth arrest and DNA damage inducible beta
10912 GADD45G; growth arrest and DNA damage inducible gamma
7185 TRAF1; TNF receptor associated factor 1
597 BCL2A1; BCL2 related protein A1
472 ATM; ATM serine/threonine kinase
55367 PIDD1; p53-induced death domain protein 1
63970 TP53AIP1; tumor protein p53 regulated apoptosis inducing protein 1
27113 BBC3; BCL2 binding component 3
5366 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
835 CASP2; caspase 2
4803 NGF; nerve growth factor
4914 NTRK1; neurotrophic receptor tyrosine kinase 1
3562 IL3; interleukin 3
3563 IL3RA; interleukin 3 receptor subunit alpha
1439 CSF2RB; colony stimulating factor 2 receptor subunit beta
5290 PIK3CA; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha
5293 PIK3CD; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit delta
5291 PIK3CB; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta
5295 PIK3R1; phosphoinositide-3-kinase regulatory subunit 1
5296 PIK3R2; phosphoinositide-3-kinase regulatory subunit 2
8503 PIK3R3; phosphoinositide-3-kinase regulatory subunit 3
5170 PDPK1; 3-phosphoinositide dependent protein kinase 1
207 AKT1; AKT serine/threonine kinase 1
208 AKT2; AKT serine/threonine kinase 2
10000 AKT3; AKT serine/threonine kinase 3
3265 HRAS; HRas proto-oncogene, GTPase
3845 KRAS; KRAS proto-oncogene, GTPase
4893 NRAS; NRAS proto-oncogene, GTPase
5894 RAF1; Raf-1 proto-oncogene, serine/threonine kinase
5604 MAP2K1; mitogen-activated protein kinase kinase 1
5605 MAP2K2; mitogen-activated protein kinase kinase 2
5594 MAPK1; mitogen-activated protein kinase 1
5595 MAPK3; mitogen-activated protein kinase 3
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K04721 TNFSF10; tumor necrosis factor ligand superfamily member 10
K04722 TNFRSF10A_B; tumor necrosis factor receptor superfamily member 10A/B
K04722 TNFRSF10A_B; tumor necrosis factor receptor superfamily member 10A/B
K04389 TNFSF6; tumor necrosis factor ligand superfamily member 6
K04390 TNFRSF6; tumor necrosis factor receptor superfamily member 6
K02373 FADD; FAS-associated death domain protein
K03156 TNF; tumor necrosis factor superfamily, member 2
K03158 TNFRSF1A; tumor necrosis factor receptor superfamily member 1A
K03171 TRADD; tumor necrosis factor receptor type 1-associated DEATH domain protein
K04724 CFLAR; CASP8 and FADD-like apoptosis regulator
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K04400 CASP10; caspase 10 [EC:3.4.22.63]
K04396 CASP6; caspase 6 [EC:3.4.22.59]
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K04397 CASP7; caspase 7 [EC:3.4.22.60]
K04726 BID; BH3 interacting domain death agonist
K02159 BAX; apoptosis regulator BAX
K14021 BAK; Bcl-2 homologous antagonist/killer
K10522 DIABLO; diablo
K16943 SEPT4; septin 4
K08669 HTRA2; HtrA serine peptidase 2 [EC:3.4.21.108]
K08738 CYC; cytochrome c
K02084 APAF1; apoptotic protease-activating factor
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K07818 PRF1; perforin 1
K01353 GZMB; granzyme B [EC:3.4.21.79]
K07374 TUBA; tubulin alpha
K07374 TUBA; tubulin alpha
K07374 TUBA; tubulin alpha
K07374 TUBA; tubulin alpha
K07374 TUBA; tubulin alpha
K07374 TUBA; tubulin alpha
K07374 TUBA; tubulin alpha
K07374 TUBA; tubulin alpha
K07374 TUBA; tubulin alpha
K02539 MCL1; myeloid leukemia cell differntiation protein MCL-1
K05692 ACTB_G1; actin beta/gamma 1
K05692 ACTB_G1; actin beta/gamma 1
K06114 SPTAN; spectrin alpha, non-erythrocytic (fodrin)
K12641 LMNA; lamin A/C
K07611 LMNB; lamin B
K07611 LMNB; lamin B
K24070 PARP1; poly [ADP-ribose] polymerase 1 [EC:2.4.2.30]
K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
K10798 PARP2_3_4; poly [ADP-ribose] polymerase 2/3/4 [EC:2.4.2.30]
K02310 DFFA; DNA fragmentation factor, 45 kD, alpha subunit
K02311 DFFB; DNA fragmentation factor, 40 kD, beta subunit [EC:3.-.-.-]
K01173 ENDOG; endonuclease G, mitochondrial
K04727 AIFM1; apoptosis-inducing factor 1 [EC:1.-.-.-]
K08852 ERN1; serine/threonine-protein kinase/endoribonuclease IRE1 [EC:2.7.11.1 3.1.26.-]
K03173 TRAF2; TNF receptor-associated factor 2 [EC:2.3.2.27]
K04958 ITPR1; inositol 1,4,5-triphosphate receptor type 1
K04959 ITPR2; inositol 1,4,5-triphosphate receptor type 2
K04960 ITPR3; inositol 1,4,5-triphosphate receptor type 3
K01367 CAPN1; calpain-1 [EC:3.4.22.52]
K03853 CAPN2; calpain-2 [EC:3.4.22.53]
K04741 CASP12; caspase 12 [EC:3.4.22.-]
K08860 EIF2AK3; eukaryotic translation initiation factor 2-alpha kinase 3 [EC:2.7.11.1]
K03237 EIF2S1; translation initiation factor 2 subunit 1
K04374 ATF4; cyclic AMP-dependent transcription factor ATF-4
K04452 DDIT3; DNA damage-inducible transcript 3
K01363 CTSB; cathepsin B [EC:3.4.22.1]
K01275 CTSC; cathepsin C [EC:3.4.14.1]
K01379 CTSD; cathepsin D [EC:3.4.23.5]
K01373 CTSF; cathepsin F [EC:3.4.22.41]
K01366 CTSH; cathepsin H [EC:3.4.22.16]
K01371 CTSK; cathepsin K [EC:3.4.22.38]
K01365 CTSL; cathepsin L [EC:3.4.22.15]
K01374 CTSO; cathepsin O [EC:3.4.22.42]
K01368 CTSS; cathepsin S [EC:3.4.22.27]
K01375 CTSL2; cathepsin V [EC:3.4.22.43]
K08569 CTSW; cathepsin W [EC:3.4.22.-]
K08568 CTSZ; cathepsin X [EC:3.4.18.1]
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K16060 BIRC2_3; baculoviral IAP repeat-containing protein 2/3
K04725 XIAP; E3 ubiquitin-protein ligase XIAP [EC:2.3.2.27]
K08731 BIRC5; baculoviral IAP repeat-containing protein 5
K16341 BCL2L11; Bcl-2-like protein 11
K04570 BCL2L1; Bcl-2-like 1 (apoptosis regulator Bcl-X)
K02161 BCL2; apoptosis regulator Bcl-2
K02308 DAXX; death-associated protein 6
K02861 RIPK1; receptor-interacting serine/threonine-protein kinase 1 [EC:2.7.11.1]
K19901 DAB2IP; disabled homolog 2-interacting protein
K04426 MAP3K5; mitogen-activated protein kinase kinase kinase 5 [EC:2.7.11.25]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K04440 JNK; mitogen-activated protein kinase 8/9/10 (c-Jun N-terminal kinase) [EC:2.7.11.24]
K02158 BAD; Bcl-2-antagonist of cell death
K04448 JUN; transcription factor AP-1
K04379 FOS; proto-oncogene protein c-fos
K04451 TP53; tumor protein p53
K02512 HRK; activator of apoptosis harakiri
K04466 MAP3K14; mitogen-activated protein kinase kinase kinase 14 [EC:2.7.11.25]
K04467 IKBKA; inhibitor of nuclear factor kappa-B kinase subunit alpha [EC:2.7.11.10]
K07209 IKBKB; inhibitor of nuclear factor kappa-B kinase subunit beta [EC:2.7.11.10]
K07210 IKBKG; inhibitor of nuclear factor kappa-B kinase subunit gamma
K04734 NFKBIA; NF-kappa-B inhibitor alpha
K02580 NFKB1; nuclear factor NF-kappa-B p105 subunit
K04735 RELA; transcription factor p65
K02374 PTPN13; tyrosine-protein phosphatase non-receptor type 13
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K03172 TRAF1; TNF receptor-associated factor 1
K02162 BCL2A1; hematopoietic Bcl-2-related protein A1
K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
K10130 LRDD; leucine-rich repeats and death domain-containing protein
K13773 TP53AIP1; p53-regulated apoptosis-inducing protein 1
K10132 BBC3; Bcl-2-binding component 3
K10131 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
K02186 CASP2; caspase 2 [EC:3.4.22.55]
K02582 NGFB; nerve growth factor, beta
K03176 NTRK1; neurotrophic tyrosine kinase receptor type 1 [EC:2.7.10.1]
K04736 IL3; interleukin 3
K04737 IL3RA; interleukin 3 receptor alpha
K04738 CSF2RB; cytokine receptor common subunit beta
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K00922 PIK3CA_B_D; phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit alpha/beta/delta [EC:2.7.1.153]
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K02649 PIK3R1_2_3; phosphoinositide-3-kinase regulatory subunit alpha/beta/delta
K06276 PDPK1; 3-phosphoinositide dependent protein kinase-1 [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K04456 AKT; RAC serine/threonine-protein kinase [EC:2.7.11.1]
K02833 HRAS; GTPase HRas
K07827 KRAS; GTPase KRas
K07828 NRAS; GTPase NRas
K04366 RAF1; RAF proto-oncogene serine/threonine-protein kinase [EC:2.7.11.1]
K04368 MAP2K1; mitogen-activated protein kinase kinase 1 [EC:2.7.12.2]
K04369 MAP2K2; mitogen-activated protein kinase kinase 2 [EC:2.7.12.2]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
K04371 ERK; mitogen-activated protein kinase 1/3 [EC:2.7.11.24]
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04214 Apoptosis - fly
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04215 Apoptosis - multiple species [PATH:hsa04215]
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04216 Ferroptosis [PATH:hsa04216]
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04217 Necroptosis [PATH:hsa04217]
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04115 p53 signaling pathway [PATH:hsa04115]
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472 ATM; ATM serine/threonine kinase
11200 CHEK2; checkpoint kinase 2
545 ATR; ATR serine/threonine kinase
1111 CHEK1; checkpoint kinase 1
92344 GORAB; golgin, RAB6 interacting
1029 CDKN2A; cyclin dependent kinase inhibitor 2A
4193 MDM2; MDM2 proto-oncogene
4194 MDM4; MDM4 regulator of p53
7157 TP53; tumor protein p53
10848 PPP1R13L; protein phosphatase 1 regulatory subunit 13 like
1026 CDKN1A; cyclin dependent kinase inhibitor 1A
595 CCND1; cyclin D1
894 CCND2; cyclin D2
896 CCND3; cyclin D3
1019 CDK4; cyclin dependent kinase 4
1021 CDK6; cyclin dependent kinase 6
898 CCNE1; cyclin E1
9134 CCNE2; cyclin E2
1017 CDK2; cyclin dependent kinase 2
2810 SFN; stratifin
56475 RPRM; reprimo, TP53 dependent G2 arrest mediator homolog
891 CCNB1; cyclin B1
9133 CCNB2; cyclin B2
983 CDK1; cyclin dependent kinase 1
1647 GADD45A; growth arrest and DNA damage inducible alpha
4616 GADD45B; growth arrest and DNA damage inducible beta
10912 GADD45G; growth arrest and DNA damage inducible gamma
51512 GTSE1; G2 and S-phase expressed 1
25946 ZNF385A; zinc finger protein 385A
355 FAS; Fas cell surface death receptor
55367 PIDD1; p53-induced death domain protein 1
8797 TNFRSF10A; TNF receptor superfamily member 10a
8795 TNFRSF10B; TNF receptor superfamily member 10b
841 CASP8; caspase 8
637 BID; BH3 interacting domain death agonist
581 BAX; BCL2 associated X, apoptosis regulator
5366 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
27113 BBC3; BCL2 binding component 3
63970 TP53AIP1; tumor protein p53 regulated apoptosis inducing protein 1
10572 SIVA1; SIVA1 apoptosis inducing factor
598 BCL2L1; BCL2 like 1
596 BCL2; BCL2 apoptosis regulator
9540 TP53I3; tumor protein p53 inducible protein 3
9538 EI24; EI24 autophagy associated transmembrane protein
51246 SHISA5; shisa family member 5
64065 PERP; p53 apoptosis effector related to PMP22
64393 ZMAT3; zinc finger matrin-type 3
6477 SIAH1; siah E3 ubiquitin protein ligase 1
54205 CYCS; cytochrome c, somatic
317 APAF1; apoptotic peptidase activating factor 1
842 CASP9; caspase 9
836 CASP3; caspase 3
84883 AIFM2; apoptosis inducing factor mitochondria associated 2
3486 IGFBP3; insulin like growth factor binding protein 3
3479 IGF1; insulin like growth factor 1
5054 SERPINE1; serpin family E member 1
575 ADGRB1; adhesion G protein-coupled receptor B1
3732 CD82; CD82 molecule
7057 THBS1; thrombospondin 1
5268 SERPINB5; serpin family B member 5
1643 DDB2; damage specific DNA binding protein 2
50484 RRM2B; ribonucleotide reductase regulatory TP53 inducible subunit M2B
6241 RRM2; ribonucleotide reductase regulatory subunit M2
27244 SESN1; sestrin 1
143686 SESN3; sestrin 3
83667 SESN2; sestrin 2
5728 PTEN; phosphatase and tensin homolog
7249 TSC2; TSC complex subunit 2
55240 STEAP3; STEAP3 metalloreductase
64326 COP1; COP1 E3 ubiquitin ligase
25898 RCHY1; ring finger and CHY zinc finger domain containing 1
900 CCNG1; cyclin G1
901 CCNG2; cyclin G2
8493 PPM1D; protein phosphatase, Mg2+/Mn2+ dependent 1D
7161 TP73; tumor protein p73
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K04728 ATM; serine-protein kinase ATM [EC:2.7.11.1]
K06641 CHEK2; serine/threonine-protein kinase CHEK2 [EC:2.7.11.1]
K06640 ATR; serine/threonine-protein kinase ATR [EC:2.7.11.1]
K02216 CHEK1; serine/threonine-protein kinase CHEK1 [EC:2.7.11.1]
K19748 GORAB; RAB6-interacting golgin
K06621 CDKN2A; cyclin-dependent kinase inhibitor 2A
K06643 MDM2; E3 ubiquitin-protein ligase Mdm2 [EC:2.3.2.27]
K10127 MDM4; protein Mdm4
K04451 TP53; tumor protein p53
K27356 PPP1R13L; RelA-associated inhibitor
K06625 CDKN1A; cyclin-dependent kinase inhibitor 1A
K04503 CCND1; G1/S-specific cyclin-D1
K10151 CCND2; G1/S-specific cyclin-D2
K10152 CCND3; G1/S-specific cyclin-D3
K02089 CDK4; cyclin-dependent kinase 4 [EC:2.7.11.22]
K02091 CDK6; cyclin-dependent kinase 6 [EC:2.7.11.22]
K06626 CCNE; G1/S-specific cyclin-E1
K06626 CCNE; G1/S-specific cyclin-E1
K02206 CDK2; cyclin-dependent kinase 2 [EC:2.7.11.22]
K06644 SFN; stratifin
K10128 RPRM; reprimo, TP53-dependent G2 arrest mediator candidate
K05868 CCNB1; G2/mitotic-specific cyclin-B1
K21770 CCNB2; G2/mitotic-specific cyclin-B2
K02087 CDK1; cyclin-dependent kinase 1 [EC:2.7.11.22 2.7.11.23]
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K04402 GADD45; growth arrest and DNA-damage-inducible protein
K10129 GTSE1; G-2 and S-phase expressed protein 1
K26543 ZNF385A; zinc finger protein 385A
K04390 TNFRSF6; tumor necrosis factor receptor superfamily member 6
K10130 LRDD; leucine-rich repeats and death domain-containing protein
K04722 TNFRSF10A_B; tumor necrosis factor receptor superfamily member 10A/B
K04722 TNFRSF10A_B; tumor necrosis factor receptor superfamily member 10A/B
K04398 CASP8; caspase 8 [EC:3.4.22.61]
K04726 BID; BH3 interacting domain death agonist
K02159 BAX; apoptosis regulator BAX
K10131 PMAIP1; phorbol-12-myristate-13-acetate-induced protein 1
K10132 BBC3; Bcl-2-binding component 3
K13773 TP53AIP1; p53-regulated apoptosis-inducing protein 1
K22744 SIVA1; apoptosis regulatory protein Siva
K04570 BCL2L1; Bcl-2-like 1 (apoptosis regulator Bcl-X)
K02161 BCL2; apoptosis regulator Bcl-2
K10133 TP53I3; tumor protein p53-inducible protein 3 [EC:1.-.-.-]
K10134 EI24; etoposide-induced 2.4 mRNA
K10135 SCOTIN; scotin
K10136 PERP; TP53 apoptosis effector
K10137 ZMAT3; zinc finger, matrin type 3
K04506 SIAH1; E3 ubiquitin-protein ligase SIAH1 [EC:2.3.2.27]
K08738 CYC; cytochrome c
K02084 APAF1; apoptotic protease-activating factor
K04399 CASP9; caspase 9 [EC:3.4.22.62]
K02187 CASP3; caspase 3 [EC:3.4.22.56]
K22745 AIFM2; apoptosis-inducing factor 2
K10138 IGFBP3; insulin-like growth factor-binding protein 3
K05459 IGF1; insulin-like growth factor 1
K03982 SERPINE1; plasminogen activator inhibitor 1
K04596 ADGRB1; adhesion G protein-coupled receptor B1
K06509 KAI1; CD82 antigen
K16857 THBS1; thrombospondin 1
K10139 SERPINB5; serpin B5
K10140 DDB2; DNA damage-binding protein 2
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
K10808 RRM2; ribonucleoside-diphosphate reductase subunit M2 [EC:1.17.4.1]
K10141 SESN1_3; sestrin 1/3
K10141 SESN1_3; sestrin 1/3
K20394 SESN2; sestrin 2
K01110 PTEN; phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN [EC:3.1.3.16 3.1.3.48 3.1.3.67]
K07207 TSC2; tuberous sclerosis 2
K10142 STEAP3; metalloreductase STEAP3 [EC:1.16.1.-]
K10143 RFWD2; E3 ubiquitin-protein ligase RFWD2 [EC:2.3.2.27]
K10144 RCHY1; RING finger and CHY zinc finger domain-containing protein 1 [EC:2.3.2.27]
K10145 CCNG1; cyclin G1
K10146 CCNG2; cyclin G2
K10147 PPM1D; protein phosphatase 1D [EC:3.1.3.16]
K10148 TP73; tumor protein p73
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04218 Cellular senescence [PATH:hsa04218]
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09144 Cellular community - eukaryotes
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09145 Cellular community - prokaryotes
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09142 Cell motility
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09150 Organismal Systems
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09160 Human Diseases
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09180 Brite Hierarchies
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09190 Not Included in Pathway or Brite
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KEGG Orthology (KO) - Homo sapiens (human)