1. Oxidoreductases

 2. Transferases

 3. Hydrolases

   3.1  Acting on ester bonds

     3.1.1  Carboxylic-ester hydrolases

       3.1.1.1  carboxylesterase

       3.1.1.2  arylesterase

       3.1.1.3  triacylglycerol lipase

       3.1.1.4  phospholipase A2

       3.1.1.5  lysophospholipase

       3.1.1.6  acetylesterase

       3.1.1.7  acetylcholinesterase

       3.1.1.8  cholinesterase

       3.1.1.10  tropinesterase

       3.1.1.11  pectinesterase

       3.1.1.13  sterol esterase

       3.1.1.14  chlorophyllase

       3.1.1.15  L-arabinonolactonase

       3.1.1.17  gluconolactonase

       3.1.1.19  uronolactonase

       3.1.1.20  tannase

       3.1.1.22  hydroxybutyrate-dimer hydrolase

       3.1.1.23  acylglycerol lipase

       3.1.1.24  3-oxoadipate enol-lactonase

       3.1.1.25  1,4-lactonase

       3.1.1.26  galactolipase

       3.1.1.27  4-pyridoxolactonase

       3.1.1.28  acylcarnitine hydrolase

       3.1.1.29  peptidyl-tRNA hydrolase

       3.1.1.30  D-arabinonolactonase

       3.1.1.31  6-phosphogluconolactonase

       3.1.1.32  phospholipase A1

       3.1.1.33  6-acetylglucose deacetylase

       3.1.1.34  lipoprotein lipase

       3.1.1.35  dihydrocoumarin hydrolase

       3.1.1.36  limonin-D-ring-lactonase

       3.1.1.37  steroid-lactonase

       3.1.1.38  triacetate-lactonase

       3.1.1.39  actinomycin lactonase

       3.1.1.40  orsellinate-depside hydrolase

       3.1.1.41  cephalosporin-C deacetylase

       3.1.1.42  chlorogenate hydrolase

       3.1.1.43  alpha-amino-acid esterase

       3.1.1.44  4-methyloxaloacetate esterase

       3.1.1.45  carboxymethylenebutenolidase

       3.1.1.46  deoxylimonate A-ring-lactonase

       3.1.1.47  1-alkyl-2-acetylglycerophosphocholine esterase

       3.1.1.48  fusarinine-C ornithinesterase

       3.1.1.49  sinapine esterase

       3.1.1.50  wax-ester hydrolase

       3.1.1.51  phorbol-diester hydrolase

       3.1.1.52  phosphatidylinositol deacylase

       3.1.1.53  sialate O-acetylesterase

       3.1.1.54  acetoxybutynylbithiophene deacetylase

       3.1.1.55  acetylsalicylate deacetylase

       3.1.1.56  methylumbelliferyl-acetate deacetylase

       3.1.1.57  2-pyrone-4,6-dicarboxylate lactonase

       3.1.1.58  N-acetylgalactosaminoglycan deacetylase

       3.1.1.59  juvenile-hormone esterase

       3.1.1.60  bis(2-ethylhexyl)phthalate esterase

       3.1.1.61  protein-glutamate methylesterase

       3.1.1.63  11-cis-retinyl-palmitate hydrolase

       3.1.1.64  retinoid isomerohydrolase

       3.1.1.65  L-rhamnono-1,4-lactonase

       3.1.1.66  5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase

       3.1.1.67  fatty-acyl-ethyl-ester synthase

       3.1.1.68  xylono-1,4-lactonase

       3.1.1.70  cetraxate benzylesterase

       3.1.1.71  acetylalkylglycerol acetylhydrolase

       3.1.1.72  acetylxylan esterase

       3.1.1.73  feruloyl esterase

       3.1.1.74  cutinase

       3.1.1.75  poly(3-hydroxybutyrate) depolymerase

       3.1.1.76  poly(3-hydroxyoctanoate) depolymerase

       3.1.1.77  acyloxyacyl hydrolase

       3.1.1.78  polyneuridine-aldehyde esterase

       3.1.1.79  hormone-sensitive lipase

       3.1.1.80  acetylajmaline esterase

       3.1.1.81  quorum-quenching N-acyl-homoserine lactonase

       3.1.1.82  pheophorbidase

       3.1.1.83  monoterpene epsilon-lactone hydrolase

       3.1.1.84  cocaine esterase

       3.1.1.85  pimelyl-[acyl-carrier protein] methyl ester esterase

       3.1.1.86  rhamnogalacturonan acetylesterase

       3.1.1.87  fumonisin B1 esterase

       3.1.1.88  pyrethroid hydrolase

       3.1.1.89  protein phosphatase methylesterase-1

       3.1.1.90  all-trans-retinyl ester 13-cis isomerohydrolase

       3.1.1.91  2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase

       3.1.1.92  4-sulfomuconolactone hydrolase

       3.1.1.93  mycophenolic acid acyl-glucuronide esterase

       3.1.1.94  versiconal hemiacetal acetate esterase

       3.1.1.95  aclacinomycin methylesterase

       3.1.1.96  D-aminoacyl-tRNA deacylase

       3.1.1.97  methylated diphthine methylhydrolase

       3.1.1.98  [Wnt protein] O-palmitoleoyl-L-serine hydrolase

       3.1.1.99  6-deoxy-6-sulfogluconolactonase

       3.1.1.100  chlorophyllide a hydrolase

       3.1.1.101  poly(ethylene terephthalate) hydrolase

       3.1.1.102  mono(ethylene terephthalate) hydrolase

       3.1.1.103  teichoic acid D-alanine hydrolase

       3.1.1.104  5-phospho-D-xylono-1,4-lactonase

       3.1.1.105  3-O-acetylpapaveroxine carboxylesterase

       3.1.1.106  O-acetyl-ADP-ribose deacetylase

       3.1.1.107  apo-salmochelin esterase

       3.1.1.108  iron(III)-enterobactin esterase

       3.1.1.109  iron(III)-salmochelin esterase

       3.1.1.110  xylono-1,5-lactonase

       3.1.1.111  phosphatidylserine sn-1 acylhydrolase

       3.1.1.112  isoamyl acetate esterase

       3.1.1.113  ethyl acetate hydrolase

       3.1.1.114  methyl acetate hydrolase

       3.1.1.115  D-apionolactonase

       3.1.1.116  sn-1-specific diacylglycerol lipase

       3.1.1.117  (4-O-methyl)-D-glucuronate---lignin esterase

       3.1.1.118  phospholipid sn-1 acylhydrolase

       3.1.1.120  L-fucono-1,5-lactonase

       3.1.1.121  ergosteryl-3beta-O-L-aspartate hydrolase

       3.1.1.122  carbendazim hydrolysing esterase

     3.1.2  Thioester hydrolases

     3.1.3  Phosphoric-monoester hydrolases

     3.1.4  Phosphoric-diester hydrolases

     3.1.5  Triphosphoric-monoester hydrolases

     3.1.6  Sulfuric-ester hydrolases

     3.1.7  Diphosphoric-monoester hydrolases

     3.1.8  Phosphoric-triester hydrolases

     3.1.11  Exodeoxyribonucleases producing 5'-phosphomonoesters

     3.1.12  Exodeoxyribonucleases producing 3'-phosphomonoesters

     3.1.13  Exoribonucleases producing 5'-phosphomonoesters

     3.1.14  Exoribonucleases producing 3'-phosphomonoesters

     3.1.15  Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters

     3.1.16  Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters

     3.1.21  Endodeoxyribonucleases producing 5'-phosphomonoesters

     3.1.22  Endodeoxyribonucleases producing 3'-phosphomonoesters

     3.1.25  Site-specific endodeoxyribonucleases that are specific for altered bases

     3.1.26  Endoribonucleases producing 5'-phosphomonoesters

     3.1.27  Endoribonucleases producing 3'-phosphomonoesters

     3.1.30  Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters

     3.1.31  Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters

   3.2  Glycosylases

   3.3  Acting on ether bonds

   3.4  Acting on peptide bonds (peptidases)

   3.5  Acting on carbon-nitrogen bonds, other than peptide bonds

     3.5.1  In linear amides

       3.5.1.1  asparaginase

       3.5.1.2  glutaminase

       3.5.1.3  omega-amidase

       3.5.1.4  amidase

       3.5.1.5  urease

       3.5.1.6  beta-ureidopropionase

       3.5.1.7  ureidosuccinase

       3.5.1.8  formylaspartate deformylase

       3.5.1.9  arylformamidase

       3.5.1.10  formyltetrahydrofolate deformylase

       3.5.1.11  penicillin amidase

       3.5.1.12  biotinidase

       3.5.1.13  aryl-acylamidase

       3.5.1.14  N-acyl-aliphatic-L-amino acid amidohydrolase

       3.5.1.15  aspartoacylase

       3.5.1.16  acetylornithine deacetylase

       3.5.1.17  acyl-lysine deacylase

       3.5.1.18  succinyl-diaminopimelate desuccinylase

       3.5.1.19  nicotinamidase

       3.5.1.20  citrullinase

       3.5.1.21  N-acetyl-beta-alanine deacetylase

       3.5.1.22  pantothenase

       3.5.1.23  ceramidase

       3.5.1.24  choloylglycine hydrolase

       3.5.1.25  N-acetylglucosamine-6-phosphate deacetylase

       3.5.1.26  N4-(beta-N-acetylglucosaminyl)-L-asparaginase

       3.5.1.28  N-acetylmuramoyl-L-alanine amidase

       3.5.1.29  2-(acetamidomethylene)succinate hydrolase

       3.5.1.30  5-aminopentanamidase

       3.5.1.31  formylmethionine deformylase

       3.5.1.32  hippurate hydrolase

       3.5.1.33  N-acetylglucosamine deacetylase

       3.5.1.35  D-glutaminase

       3.5.1.36  N-methyl-2-oxoglutaramate hydrolase

       3.5.1.38  glutamin-(asparagin-)ase

       3.5.1.39  alkylamidase

       3.5.1.40  acylagmatine amidase

       3.5.1.41  chitin deacetylase

       3.5.1.42  nicotinamide-nucleotide amidase

       3.5.1.43  peptidyl-glutaminase

       3.5.1.44  protein-glutamine glutaminase

       3.5.1.46  6-aminohexanoate-oligomer exohydrolase

       3.5.1.47  N-acetyldiaminopimelate deacetylase

       3.5.1.48  acetylspermidine deacetylase

       3.5.1.49  formamidase

       3.5.1.50  pentanamidase

       3.5.1.51  4-acetamidobutyryl-CoA deacetylase

       3.5.1.52  peptide-N4-(N-acetyl-beta-glucosaminyl)asparagine amidase

       3.5.1.53  N-carbamoylputrescine amidase

       3.5.1.54  allophanate hydrolase

       3.5.1.55  long-chain-fatty-acyl-glutamate deacylase

       3.5.1.56  N,N-dimethylformamidase

       3.5.1.57  tryptophanamidase

       3.5.1.58  N-benzyloxycarbonylglycine hydrolase

       3.5.1.59  N-carbamoylsarcosine amidase

       3.5.1.60  N-(long-chain-acyl)ethanolamine deacylase

       3.5.1.62  acetylputrescine deacetylase

       3.5.1.63  4-acetamidobutyrate deacetylase

       3.5.1.64  Nalpha-benzyloxycarbonylleucine hydrolase

       3.5.1.65  theanine hydrolase

       3.5.1.66  2-(hydroxymethyl)-3-(acetamidomethylene)succinate hydrolase

       3.5.1.67  4-methyleneglutaminase

       3.5.1.68  N-formylglutamate deformylase

       3.5.1.69  glycosphingolipid deacylase

       3.5.1.70  aculeacin-A deacylase

       3.5.1.71  N-feruloylglycine deacylase

       3.5.1.72  D-benzoylarginine-4-nitroanilide amidase

       3.5.1.73  carnitinamidase

       3.5.1.74  chenodeoxycholoyltaurine hydrolase

       3.5.1.75  urethanase

       3.5.1.76  arylalkyl acylamidase

       3.5.1.77  N-carbamoyl-D-amino-acid hydrolase

       3.5.1.78  glutathionylspermidine amidase

       3.5.1.79  phthalyl amidase

       3.5.1.81  N-acyl-D-amino-acid deacylase

       3.5.1.82  N-acyl-D-glutamate deacylase

       3.5.1.83  N-acyl-D-aspartate deacylase

       3.5.1.84  biuret amidohydrolase

       3.5.1.85  (S)-N-acetyl-1-phenylethylamine hydrolase

       3.5.1.86  mandelamide amidase

       3.5.1.87  N-carbamoyl-L-amino-acid hydrolase

       3.5.1.88  peptide deformylase

       3.5.1.89  N-acetylglucosaminylphosphatidylinositol deacetylase

       3.5.1.90  adenosylcobinamide hydrolase

       3.5.1.91  N-substituted formamide deformylase

       3.5.1.92  pantetheine hydrolase

       3.5.1.93  glutaryl-7-aminocephalosporanic-acid acylase

       3.5.1.94  gamma-glutamyl-gamma-aminobutyrate hydrolase

       3.5.1.95  N-malonylurea hydrolase

       3.5.1.96  succinylglutamate desuccinylase

       3.5.1.97  acyl-homoserine-lactone acylase

       3.5.1.98  histone deacetylase

       3.5.1.99  fatty acid amide hydrolase

       3.5.1.100  (R)-amidase

       3.5.1.101  L-proline amide hydrolase

       3.5.1.102  2-amino-5-formylamino-6-ribosylaminopyrimidin-4(3H)-one 5'-monophosphate deformylase

       3.5.1.103  N-acetyl-1-D-myo-inositol-2-amino-2-deoxy-alpha-D-glucopyranoside deacetylase

       3.5.1.104  peptidoglycan-N-acetylglucosamine deacetylase

       3.5.1.105  chitin disaccharide deacetylase

       3.5.1.106  N-formylmaleamate deformylase

       3.5.1.107  maleamate amidohydrolase

       3.5.1.108  UDP-3-O-acyl-N-acetylglucosamine deacetylase

       3.5.1.109  sphingomyelin deacylase

       3.5.1.110  ureidoacrylate amidohydrolase

       3.5.1.111  2-oxoglutaramate amidase

       3.5.1.112  2'-N-acetylparomamine deacetylase

       3.5.1.113  2'''-acetyl-6'''-hydroxyneomycin C deacetylase

       3.5.1.114  N-acyl-aromatic-L-amino acid amidohydrolase

       3.5.1.115  mycothiol S-conjugate amidase

       3.5.1.116  ureidoglycolate amidohydrolase

       3.5.1.117  6-aminohexanoate-oligomer endohydrolase

       3.5.1.118  gamma-glutamyl hercynylcysteine S-oxide hydrolase

       3.5.1.119  Pup amidohydrolase

       3.5.1.121  protein N-terminal asparagine amidohydrolase

       3.5.1.122  protein N-terminal glutamine amidohydrolase

       3.5.1.123  gamma-glutamylanilide hydrolase

       3.5.1.124  protein deglycase

       3.5.1.125  N2-acetyl-L-2,4-diaminobutanoate deacetylase

       3.5.1.126  oxamate amidohydrolase

       3.5.1.127  jasmonoyl-L-amino acid hydrolase

       3.5.1.128  deaminated glutathione amidase

       3.5.1.129  N5-(cytidine 5'-diphosphoramidyl)-L-glutamine hydrolase

       3.5.1.130  [amino group carrier protein]-lysine hydrolase

       3.5.1.131  1-carboxybiuret hydrolase

       3.5.1.132  [amino group carrier protein]-ornithine hydrolase

       3.5.1.133  Nalpha-acyl-L-glutamine aminoacylase

       3.5.1.134  (indol-3-yl)acetyl-L-aspartate hydrolase

       3.5.1.135  N4-acetylcytidine amidohydrolase

       3.5.1.136  N,N'-diacetylchitobiose non-reducing end deacetylase

       3.5.1.137  N-methylcarbamate hydrolase

       3.5.1.138  lipoamidase

     3.5.2  In cyclic amides

     3.5.3  In linear amidines

     3.5.4  In cyclic amidines

     3.5.5  In nitriles

     3.5.99  In other compounds

   3.6  Acting on acid anhydrides

   3.7  Acting on carbon-carbon bonds

   3.8  Acting on halide bonds

   3.9  Acting on phosphorus-nitrogen bonds

   3.10  Acting on sulfur-nitrogen bonds

   3.11  Acting on carbon-phosphorus bonds

   3.12  Acting on sulfur-sulfur bonds

   3.13  Acting on carbon-sulfur bonds

 4. Lyases

 5. Isomerases

 6. Ligases

 7. Translocases