1. Oxidoreductases

 2. Transferases

 3. Hydrolases

   3.1  Acting on ester bonds

     3.1.1  Carboxylic-ester hydrolases

       3.1.1.1  carboxylesterase

       3.1.1.2  arylesterase

       3.1.1.3  triacylglycerol lipase

       3.1.1.4  phospholipase A2

       3.1.1.5  lysophospholipase

       3.1.1.6  acetylesterase

       3.1.1.7  acetylcholinesterase

       3.1.1.8  cholinesterase

       3.1.1.10  tropinesterase

       3.1.1.11  pectinesterase

       3.1.1.13  sterol esterase

       3.1.1.14  chlorophyllase

       3.1.1.15  L-arabinonolactonase

       3.1.1.17  gluconolactonase

       3.1.1.19  uronolactonase

       3.1.1.20  tannase

       3.1.1.22  hydroxybutyrate-dimer hydrolase

       3.1.1.23  acylglycerol lipase

       3.1.1.24  3-oxoadipate enol-lactonase

       3.1.1.25  1,4-lactonase

       3.1.1.26  galactolipase

       3.1.1.27  4-pyridoxolactonase

       3.1.1.28  acylcarnitine hydrolase

       3.1.1.29  peptidyl-tRNA hydrolase

       3.1.1.30  D-arabinonolactonase

       3.1.1.31  6-phosphogluconolactonase

       3.1.1.32  phospholipase A1

       3.1.1.33  6-acetylglucose deacetylase

       3.1.1.34  lipoprotein lipase

       3.1.1.35  dihydrocoumarin hydrolase

       3.1.1.36  limonin-D-ring-lactonase

       3.1.1.37  steroid-lactonase

       3.1.1.38  triacetate-lactonase

       3.1.1.39  actinomycin lactonase

       3.1.1.40  orsellinate-depside hydrolase

       3.1.1.41  cephalosporin-C deacetylase

       3.1.1.42  chlorogenate hydrolase

       3.1.1.43  alpha-amino-acid esterase

       3.1.1.44  4-methyloxaloacetate esterase

       3.1.1.45  carboxymethylenebutenolidase

       3.1.1.46  deoxylimonate A-ring-lactonase

       3.1.1.47  1-alkyl-2-acetylglycerophosphocholine esterase

       3.1.1.48  fusarinine-C ornithinesterase

       3.1.1.49  sinapine esterase

       3.1.1.50  wax-ester hydrolase

       3.1.1.51  phorbol-diester hydrolase

       3.1.1.52  phosphatidylinositol deacylase

       3.1.1.53  sialate O-acetylesterase

       3.1.1.54  acetoxybutynylbithiophene deacetylase

       3.1.1.55  acetylsalicylate deacetylase

       3.1.1.56  methylumbelliferyl-acetate deacetylase

       3.1.1.57  2-pyrone-4,6-dicarboxylate lactonase

       3.1.1.58  N-acetylgalactosaminoglycan deacetylase

       3.1.1.59  juvenile-hormone esterase

       3.1.1.60  bis(2-ethylhexyl)phthalate esterase

       3.1.1.61  protein-glutamate methylesterase

       3.1.1.63  11-cis-retinyl-palmitate hydrolase

       3.1.1.64  retinoid isomerohydrolase

       3.1.1.65  L-rhamnono-1,4-lactonase

       3.1.1.66  5-(3,4-diacetoxybut-1-ynyl)-2,2'-bithiophene deacetylase

       3.1.1.67  fatty-acyl-ethyl-ester synthase

       3.1.1.68  xylono-1,4-lactonase

       3.1.1.70  cetraxate benzylesterase

       3.1.1.71  acetylalkylglycerol acetylhydrolase

       3.1.1.72  acetylxylan esterase

       3.1.1.73  feruloyl esterase

       3.1.1.74  cutinase

       3.1.1.75  poly(3-hydroxybutyrate) depolymerase

       3.1.1.76  poly(3-hydroxyoctanoate) depolymerase

       3.1.1.77  acyloxyacyl hydrolase

       3.1.1.78  polyneuridine-aldehyde esterase

       3.1.1.79  hormone-sensitive lipase

       3.1.1.80  acetylajmaline esterase

       3.1.1.81  quorum-quenching N-acyl-homoserine lactonase

       3.1.1.82  pheophorbidase

       3.1.1.83  monoterpene epsilon-lactone hydrolase

       3.1.1.84  cocaine esterase

       3.1.1.85  pimelyl-[acyl-carrier protein] methyl ester esterase

       3.1.1.86  rhamnogalacturonan acetylesterase

       3.1.1.87  fumonisin B1 esterase

       3.1.1.88  pyrethroid hydrolase

       3.1.1.89  protein phosphatase methylesterase-1

       3.1.1.90  all-trans-retinyl ester 13-cis isomerohydrolase

       3.1.1.91  2-oxo-3-(5-oxofuran-2-ylidene)propanoate lactonase

       3.1.1.92  4-sulfomuconolactone hydrolase

       3.1.1.93  mycophenolic acid acyl-glucuronide esterase

       3.1.1.94  versiconal hemiacetal acetate esterase

       3.1.1.95  aclacinomycin methylesterase

       3.1.1.96  D-aminoacyl-tRNA deacylase

       3.1.1.97  methylated diphthine methylhydrolase

       3.1.1.98  [Wnt protein] O-palmitoleoyl-L-serine hydrolase

       3.1.1.99  6-deoxy-6-sulfogluconolactonase

       3.1.1.100  chlorophyllide a hydrolase

       3.1.1.101  poly(ethylene terephthalate) hydrolase

       3.1.1.102  mono(ethylene terephthalate) hydrolase

       3.1.1.103  teichoic acid D-alanine hydrolase

       3.1.1.104  5-phospho-D-xylono-1,4-lactonase

       3.1.1.105  3-O-acetylpapaveroxine carboxylesterase

       3.1.1.106  O-acetyl-ADP-ribose deacetylase

       3.1.1.107  apo-salmochelin esterase

       3.1.1.108  iron(III)-enterobactin esterase

       3.1.1.109  iron(III)-salmochelin esterase

       3.1.1.110  xylono-1,5-lactonase

       3.1.1.111  phosphatidylserine sn-1 acylhydrolase

       3.1.1.112  isoamyl acetate esterase

       3.1.1.113  ethyl acetate hydrolase

       3.1.1.114  methyl acetate hydrolase

       3.1.1.115  D-apionolactonase

       3.1.1.116  sn-1-specific diacylglycerol lipase

       3.1.1.117  (4-O-methyl)-D-glucuronate---lignin esterase

       3.1.1.118  phospholipid sn-1 acylhydrolase

       3.1.1.120  L-fucono-1,5-lactonase

       3.1.1.121  ergosteryl-3beta-O-L-aspartate hydrolase

       3.1.1.122  carbendazim hydrolysing esterase

     3.1.2  Thioester hydrolases

     3.1.3  Phosphoric-monoester hydrolases

     3.1.4  Phosphoric-diester hydrolases

     3.1.5  Triphosphoric-monoester hydrolases

     3.1.6  Sulfuric-ester hydrolases

     3.1.7  Diphosphoric-monoester hydrolases

     3.1.8  Phosphoric-triester hydrolases

     3.1.11  Exodeoxyribonucleases producing 5'-phosphomonoesters

     3.1.12  Exodeoxyribonucleases producing 3'-phosphomonoesters

     3.1.13  Exoribonucleases producing 5'-phosphomonoesters

     3.1.14  Exoribonucleases producing 3'-phosphomonoesters

     3.1.15  Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters

     3.1.16  Exonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters

     3.1.21  Endodeoxyribonucleases producing 5'-phosphomonoesters

     3.1.22  Endodeoxyribonucleases producing 3'-phosphomonoesters

     3.1.25  Site-specific endodeoxyribonucleases that are specific for altered bases

     3.1.26  Endoribonucleases producing 5'-phosphomonoesters

     3.1.27  Endoribonucleases producing 3'-phosphomonoesters

     3.1.30  Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 5'-phosphomonoesters

     3.1.31  Endoribonucleases that are active with either ribo- or deoxyribonucleic acids and produce 3'-phosphomonoesters

   3.2  Glycosylases

   3.3  Acting on ether bonds

   3.4  Acting on peptide bonds (peptidases)

   3.5  Acting on carbon-nitrogen bonds, other than peptide bonds

   3.6  Acting on acid anhydrides

   3.7  Acting on carbon-carbon bonds

   3.8  Acting on halide bonds

   3.9  Acting on phosphorus-nitrogen bonds

   3.10  Acting on sulfur-nitrogen bonds

   3.11  Acting on carbon-phosphorus bonds

   3.12  Acting on sulfur-sulfur bonds

   3.13  Acting on carbon-sulfur bonds

 4. Lyases

 5. Isomerases

 6. Ligases

 7. Translocases