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KO |
 09100 Metabolism
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 09120 Genetic Information Processing
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09121 Transcription
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09122 Translation
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03010 Ribosome [PATH:tle03010]
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00970 Aminoacyl-tRNA biosynthesis [PATH:tle00970]
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 Tlet_R0011 tRNA-Ala
Tlet_R0019 tRNA-Ala
Tlet_R0050 tRNA-Ala
Tlet_R0030 tRNA-Arg
Tlet_R0026 tRNA-Arg
Tlet_R0024 tRNA-Arg
Tlet_R0006 tRNA-Arg
Tlet_R0045 tRNA-Arg
Tlet_R0040 tRNA-Asn
Tlet_R0012 tRNA-Asp
Tlet_R0027 tRNA-Cys
Tlet_R0010 tRNA-Gln
Tlet_R0033 tRNA-Gln
Tlet_R0020 tRNA-Glu
Tlet_R0016 tRNA-Glu
Tlet_R0023 tRNA-Gly
Tlet_R0032 tRNA-Gly
Tlet_R0037 tRNA-Gly
Tlet_R0025 tRNA-His
Tlet_R0051 tRNA-Ile
Tlet_R0002 tRNA-Leu
Tlet_R0036 tRNA-Leu
Tlet_R0028 tRNA-Leu
Tlet_R0015 tRNA-Leu
Tlet_R0029 tRNA-Leu
Tlet_R0031 tRNA-Lys
Tlet_R0035 tRNA-Lys
Tlet_R0042 tRNA-Met
Tlet_R0039 tRNA-Met
Tlet_R0003 tRNA-Met
Tlet_R0021 tRNA-Phe
Tlet_R0034 tRNA-Pro
Tlet_R0017 tRNA-Pro
Tlet_R0014 tRNA-Pro
Tlet_R0044 tRNA-Ser
Tlet_R0047 tRNA-Ser
Tlet_R0004 tRNA-Ser
Tlet_R0041 tRNA-Ser
Tlet_R0007 tRNA-Thr
Tlet_R0046 tRNA-Thr
Tlet_R0038 tRNA-Thr
Tlet_R0009 tRNA-Trp
Tlet_R0008 tRNA-Tyr
Tlet_R0043 tRNA-Val
Tlet_R0022 tRNA-Val
Tlet_R0001 tRNA-Val
Tlet_0765 glutamyl-tRNA synthetase
Tlet_0411 Amidase
Tlet_0844 glutamyl-tRNA(Gln) amidotransferase, A subunit
Tlet_0843 glutamyl-tRNA(Gln) amidotransferase, B subunit
Tlet_0668 glutamyl-tRNA(Gln) amidotransferase, C subunit
Tlet_1796 alanyl-tRNA synthetase
Tlet_0558 Threonyl/alanyl tRNA synthetase SAD
Tlet_1647 aspartyl-tRNA synthetase
Tlet_0927 asparaginyl-tRNA synthetase
Tlet_0468 glycyl-tRNA synthetase, alpha subunit
Tlet_0467 glycyl-tRNA synthetase, beta subunit
Tlet_1988 threonyl-tRNA synthetase
Tlet_0230 seryl-tRNA synthetase
Tlet_0764 cysteinyl-tRNA synthetase
Tlet_0348 methionyl-tRNA synthetase
Tlet_0693 methionyl-tRNA formyltransferase
Tlet_1983 valyl-tRNA synthetase
Tlet_1847 leucyl-tRNA synthetase
Tlet_0382 isoleucyl-tRNA synthetase
Tlet_0518 lysyl-tRNA synthetase
Tlet_1734 arginyl-tRNA synthetase
Tlet_0246 prolyl-tRNA synthetase
Tlet_0761 histidyl-tRNA synthetase
Tlet_0057 phenylalanyl-tRNA synthetase, alpha subunit
Tlet_0056 phenylalanyl-tRNA synthetase, beta subunit
Tlet_1720 tyrosyl-tRNA synthetase
Tlet_1515 tryptophanyl-tRNA synthetase
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K14218 tRNA-Ala; tRNA Ala
K14218 tRNA-Ala; tRNA Ala
K14218 tRNA-Ala; tRNA Ala
K14219 tRNA-Arg; tRNA Arg
K14219 tRNA-Arg; tRNA Arg
K14219 tRNA-Arg; tRNA Arg
K14219 tRNA-Arg; tRNA Arg
K14219 tRNA-Arg; tRNA Arg
K14220 tRNA-Asn; tRNA Asn
K14221 tRNA-Asp; tRNA Asp
K14222 tRNA-Cys; tRNA Cys
K14223 tRNA-Gln; tRNA Gln
K14223 tRNA-Gln; tRNA Gln
K14224 tRNA-Glu; tRNA Glu
K14224 tRNA-Glu; tRNA Glu
K14225 tRNA-Gly; tRNA Gly
K14225 tRNA-Gly; tRNA Gly
K14225 tRNA-Gly; tRNA Gly
K14226 tRNA-His; tRNA His
K14227 tRNA-Ile; tRNA Ile
K14228 tRNA-Leu; tRNA Leu
K14228 tRNA-Leu; tRNA Leu
K14228 tRNA-Leu; tRNA Leu
K14228 tRNA-Leu; tRNA Leu
K14228 tRNA-Leu; tRNA Leu
K14229 tRNA-Lys; tRNA Lys
K14229 tRNA-Lys; tRNA Lys
K14230 tRNA-Met; tRNA Met
K14230 tRNA-Met; tRNA Met
K14230 tRNA-Met; tRNA Met
K14231 tRNA-Phe; tRNA Phe
K14232 tRNA-Pro; tRNA Pro
K14232 tRNA-Pro; tRNA Pro
K14232 tRNA-Pro; tRNA Pro
K14233 tRNA-Ser; tRNA Ser
K14233 tRNA-Ser; tRNA Ser
K14233 tRNA-Ser; tRNA Ser
K14233 tRNA-Ser; tRNA Ser
K14234 tRNA-Thr; tRNA Thr
K14234 tRNA-Thr; tRNA Thr
K14234 tRNA-Thr; tRNA Thr
K14235 tRNA-Trp; tRNA Trp
K14236 tRNA-Tyr; tRNA Tyr
K14237 tRNA-Val; tRNA Val
K14237 tRNA-Val; tRNA Val
K14237 tRNA-Val; tRNA Val
K09698 gltX; nondiscriminating glutamyl-tRNA synthetase [EC:6.1.1.24]
K02433 gatA; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]
K02433 gatA; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit A [EC:6.3.5.6 6.3.5.7]
K02434 gatB; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit B [EC:6.3.5.6 6.3.5.7]
K02435 gatC; aspartyl-tRNA(Asn)/glutamyl-tRNA(Gln) amidotransferase subunit C [EC:6.3.5.6 6.3.5.7]
K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]
K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]
K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
K00604 MTFMT; methionyl-tRNA formyltransferase [EC:2.1.2.9]
K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
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03013 Nucleocytoplasmic transport
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03015 mRNA surveillance pathway
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03008 Ribosome biogenesis in eukaryotes
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09123 Folding, sorting and degradation
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09124 Replication and repair
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09126 Chromosome
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09125 Information processing in viruses
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09130 Environmental Information Processing
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09140 Cellular Processes
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09150 Organismal Systems
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09160 Human Diseases
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09180 Brite Hierarchies
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09181 Protein families: metabolism
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01000 Enzymes [BR:tle01000]
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01001 Protein kinases [BR:tle01001]
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01009 Protein phosphatases and associated proteins [BR:tle01009]
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01002 Peptidases and inhibitors [BR:tle01002]
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01003 Glycosyltransferases [BR:tle01003]
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01005 Lipopolysaccharide biosynthesis proteins [BR:tle01005]
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01011 Peptidoglycan biosynthesis and degradation proteins [BR:tle01011]
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01004 Lipid biosynthesis proteins [BR:tle01004]
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01008 Polyketide biosynthesis proteins [BR:tle01008]
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01006 Prenyltransferases [BR:tle01006]
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01007 Amino acid related enzymes [BR:tle01007]
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Tlet_0765 glutamyl-tRNA synthetase
Tlet_1720 tyrosyl-tRNA synthetase
Tlet_1515 tryptophanyl-tRNA synthetase
Tlet_0764 cysteinyl-tRNA synthetase
Tlet_1734 arginyl-tRNA synthetase
Tlet_0348 methionyl-tRNA synthetase
Tlet_0382 isoleucyl-tRNA synthetase
Tlet_1983 valyl-tRNA synthetase
Tlet_1847 leucyl-tRNA synthetase
Tlet_0518 lysyl-tRNA synthetase
Tlet_1647 aspartyl-tRNA synthetase
Tlet_0927 asparaginyl-tRNA synthetase
Tlet_0761 histidyl-tRNA synthetase
Tlet_0468 glycyl-tRNA synthetase, alpha subunit
Tlet_0467 glycyl-tRNA synthetase, beta subunit
Tlet_0230 seryl-tRNA synthetase
Tlet_0246 prolyl-tRNA synthetase
Tlet_1988 threonyl-tRNA synthetase
Tlet_1796 alanyl-tRNA synthetase
Tlet_0558 Threonyl/alanyl tRNA synthetase SAD
Tlet_0057 phenylalanyl-tRNA synthetase, alpha subunit
Tlet_0056 phenylalanyl-tRNA synthetase, beta subunit
Tlet_0297 aminotransferase class I and II
Tlet_0495 aminotransferase class I and II
Tlet_1241 aminotransferase class I and II
Tlet_2009 Glycine C-acetyltransferase
Tlet_1859 aminotransferase class I and II
Tlet_0944 ornithine aminotransferase
Tlet_0368 acetylornithine and succinylornithine aminotransferase
Tlet_1058 aminotransferase class IV
Tlet_1087 DegT/DnrJ/EryC1/StrS aminotransferase
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K09698 gltX; nondiscriminating glutamyl-tRNA synthetase [EC:6.1.1.24]
K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]
K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]
K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
K00812 aspB; aspartate aminotransferase [EC:2.6.1.1]
K00812 aspB; aspartate aminotransferase [EC:2.6.1.1]
K00817 hisC; histidinol-phosphate aminotransferase [EC:2.6.1.9]
K00639 kbl; glycine C-acetyltransferase [EC:2.3.1.29]
K14155 patB; cysteine-S-conjugate beta-lyase [EC:4.4.1.13]
K00819 rocD; ornithine--oxo-acid transaminase [EC:2.6.1.13]
K00821 argD; acetylornithine/N-succinyldiaminopimelate aminotransferase [EC:2.6.1.11 2.6.1.17]
K00826 E2.6.1.42; branched-chain amino acid aminotransferase [EC:2.6.1.42]
K13010 per; perosamine synthetase [EC:2.6.1.102]
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00199 Cytochrome P450
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00194 Photosynthesis proteins [BR:tle00194]
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09182 Protein families: genetic information processing
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03000 Transcription factors [BR:tle03000]
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03021 Transcription machinery [BR:tle03021]
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03019 Messenger RNA biogenesis [BR:tle03019]
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03041 Spliceosome
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03011 Ribosome [BR:tle03011]
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03009 Ribosome biogenesis [BR:tle03009]
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03016 Transfer RNA biogenesis [BR:tle03016]
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Tlet_1093 beta-lactamase domain protein
Tlet_1600 beta-lactamase domain protein
Tlet_1714 CBS domain containing protein
Tlet_0926 protein of unknown function UPF0027
Tlet_0346 conserved hypothetical protein
Tlet_0246 prolyl-tRNA synthetase
Tlet_0382 isoleucyl-tRNA synthetase
Tlet_1847 leucyl-tRNA synthetase
Tlet_0348 methionyl-tRNA synthetase
Tlet_1734 arginyl-tRNA synthetase
Tlet_0518 lysyl-tRNA synthetase
Tlet_1647 aspartyl-tRNA synthetase
Tlet_1796 alanyl-tRNA synthetase
Tlet_0558 Threonyl/alanyl tRNA synthetase SAD
Tlet_0927 asparaginyl-tRNA synthetase
Tlet_1988 threonyl-tRNA synthetase
Tlet_0230 seryl-tRNA synthetase
Tlet_0764 cysteinyl-tRNA synthetase
Tlet_1983 valyl-tRNA synthetase
Tlet_0761 histidyl-tRNA synthetase
Tlet_0057 phenylalanyl-tRNA synthetase, alpha subunit
Tlet_0056 phenylalanyl-tRNA synthetase, beta subunit
Tlet_1720 tyrosyl-tRNA synthetase
Tlet_1515 tryptophanyl-tRNA synthetase
Tlet_0688 D-tyrosyl-tRNA(Tyr) deacylase
Tlet_0513 tRNA (adenine-N(1)-)-methyltransferase
Tlet_0003 tRNA (guanine-N(7)-)-methyltransferase
Tlet_0694 tRNA pseudouridine synthase A
Tlet_1379 tRNA pseudouridine synthase B
Tlet_0716 aminotransferase class V
Tlet_0718 aminotransferase class V
Tlet_1383 Sua5/YciO/YrdC/YwlC family protein
Tlet_0781 tRNA delta(2)-isopentenylpyrophosphate transferase
Tlet_1410 tRNA modification GTPase TrmE
Tlet_0690 glucose inhibited division protein A
Tlet_0793 ribonuclease P protein component
Tlet_R0013 RNA component of RNaseP
Tlet_2041 2'-5' RNA ligase
Tlet_0468 glycyl-tRNA synthetase, alpha subunit
Tlet_0467 glycyl-tRNA synthetase, beta subunit
Tlet_0765 glutamyl-tRNA synthetase
Tlet_1323 CMP/dCMP deaminase zinc-binding
Tlet_0397 dihydrouridine synthase DuS
Tlet_1393 RNA modification enzyme, MiaB family
Tlet_1059 MiaB-like tRNA modifying enzyme
Tlet_0684 gid protein
Tlet_0125 tRNA (guanine-N1)-methyltransferase
Tlet_0294 methyltransferase small
Tlet_0846 tRNA (5-methylaminomethyl-2-thiouridylate)-methyltransferase
Tlet_0417 thiamine biosynthesis protein
Tlet_0661 S-adenosylmethionine--tRNA-ribosyltransferase-isomerase
Tlet_1639 6-pyruvoyl tetrahydropterin synthase and hypothetical protein
Tlet_0687 protein of unknown function DUF208
Tlet_0446 queuine tRNA-ribosyltransferase
Tlet_1536 tRNA(Ile)-lysidine synthetase
Tlet_1484 peptidase M22 glycoprotease
Tlet_0547 putative metalloendopeptidase, glycoprotease family
Tlet_1740 protein of unknown function UPF0079
Tlet_0567 protein of unknown function DUF795
Tlet_0744 ribonuclease R
Tlet_1402 Polyribonucleotide nucleotidyltransferase
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K00784 rnz; ribonuclease Z [EC:3.1.26.11]
K00784 rnz; ribonuclease Z [EC:3.1.26.11]
K00974 cca; tRNA nucleotidyltransferase (CCA-adding enzyme) [EC:2.7.7.72 3.1.3.- 3.1.4.-]
K14415 RTCB; tRNA-splicing ligase RtcB (3'-phosphate/5'-hydroxy nucleic acid ligase) [EC:6.5.1.8]
K24956 ZBTB8OS; protein archease
K01881 PARS; prolyl-tRNA synthetase [EC:6.1.1.15]
K01870 IARS; isoleucyl-tRNA synthetase [EC:6.1.1.5]
K01869 LARS; leucyl-tRNA synthetase [EC:6.1.1.4]
K01874 MARS; methionyl-tRNA synthetase [EC:6.1.1.10]
K01887 RARS; arginyl-tRNA synthetase [EC:6.1.1.19]
K04567 KARS; lysyl-tRNA synthetase, class II [EC:6.1.1.6]
K01876 DARS2; aspartyl-tRNA synthetase [EC:6.1.1.12]
K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
K01872 AARS; alanyl-tRNA synthetase [EC:6.1.1.7]
K01893 NARS; asparaginyl-tRNA synthetase [EC:6.1.1.22]
K01868 TARS; threonyl-tRNA synthetase [EC:6.1.1.3]
K01875 SARS; seryl-tRNA synthetase [EC:6.1.1.11]
K01883 CARS; cysteinyl-tRNA synthetase [EC:6.1.1.16]
K01873 VARS; valyl-tRNA synthetase [EC:6.1.1.9]
K01892 HARS; histidyl-tRNA synthetase [EC:6.1.1.21]
K01889 FARSA; phenylalanyl-tRNA synthetase alpha chain [EC:6.1.1.20]
K01890 FARSB; phenylalanyl-tRNA synthetase beta chain [EC:6.1.1.20]
K01866 YARS; tyrosyl-tRNA synthetase [EC:6.1.1.1]
K01867 WARS; tryptophanyl-tRNA synthetase [EC:6.1.1.2]
K07560 dtd; D-aminoacyl-tRNA deacylase [EC:3.1.1.96]
K07442 TRM61; tRNA (adenine57-N1/adenine58-N1)-methyltransferase catalytic subunit [EC:2.1.1.219 2.1.1.220]
K03439 trmB; tRNA (guanine-N7-)-methyltransferase [EC:2.1.1.33]
K06173 truA; tRNA pseudouridine38-40 synthase [EC:5.4.99.12]
K03177 truB; tRNA pseudouridine55 synthase [EC:5.4.99.25]
K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
K04487 iscS; cysteine desulfurase [EC:2.8.1.7]
K07566 tsaC; L-threonylcarbamoyladenylate synthase [EC:2.7.7.87]
K00791 miaA; tRNA dimethylallyltransferase [EC:2.5.1.75]
K03650 mnmE; tRNA modification GTPase [EC:3.6.-.-]
K03495 gidA; tRNA uridine 5-carboxymethylaminomethyl modification enzyme
K03536 rnpA; ribonuclease P protein component [EC:3.1.26.5]
K01978 rnpB; M1 RNA
K01975 thpR; RNA 2',3'-cyclic 3'-phosphodiesterase [EC:3.1.4.58]
K01878 glyQ; glycyl-tRNA synthetase alpha chain [EC:6.1.1.14]
K01879 glyS; glycyl-tRNA synthetase beta chain [EC:6.1.1.14]
K09698 gltX; nondiscriminating glutamyl-tRNA synthetase [EC:6.1.1.24]
K11991 tadA; tRNA(adenine34) deaminase [EC:3.5.4.33]
K05540 dusB; tRNA-dihydrouridine synthase B [EC:1.-.-.-]
K06168 miaB; tRNA-2-methylthio-N6-dimethylallyladenosine synthase [EC:2.8.4.3]
K18707 mtaB; threonylcarbamoyladenosine tRNA methylthiotransferase MtaB [EC:2.8.4.5]
K04094 trmFO; methylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase [EC:2.1.1.74]
K00554 trmD; tRNA (guanine37-N1)-methyltransferase [EC:2.1.1.228]
K15460 yfiC; tRNA1Val (adenine37-N6)-methyltransferase [EC:2.1.1.223]
K00566 mnmA; tRNA-uridine 2-sulfurtransferase [EC:2.8.1.13]
K21947 ttuA; tRNA-5-methyluridine54 2-sulfurtransferase [EC:2.8.1.15]
K07568 queA; S-adenosylmethionine:tRNA ribosyltransferase-isomerase [EC:2.4.99.17]
K01737 queD; 6-pyruvoyltetrahydropterin/6-carboxytetrahydropterin synthase [EC:4.2.3.12 4.1.2.50]
K09765 queH; epoxyqueuosine reductase [EC:1.17.99.6]
K00773 tgt; queuine tRNA-ribosyltransferase [EC:2.4.2.29]
K04075 tilS; tRNA(Ile)-lysidine synthase [EC:6.3.4.19]
K14742 tsaB; tRNA threonylcarbamoyladenosine biosynthesis protein TsaB
K25706 tsaD; tRNA N6-adenosine threonylcarbamoyltransferase [EC:2.3.1.234]
K06925 tsaE; tRNA threonylcarbamoyladenosine biosynthesis protein TsaE
K27343 tmcAL; tRNA(Met) cytidine acetate ligase [EC:6.3.4.-]
K12573 rnr; ribonuclease R [EC:3.1.13.1]
K00962 pnp; polyribonucleotide nucleotidyltransferase [EC:2.7.7.8]
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03012 Translation factors [BR:tle03012]
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03110 Chaperones and folding catalysts [BR:tle03110]
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04131 Membrane trafficking [BR:tle04131]
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04121 Ubiquitin system
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03051 Proteasome
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03032 DNA replication proteins [BR:tle03032]
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03036 Chromosome and associated proteins [BR:tle03036]
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03400 DNA repair and recombination proteins [BR:tle03400]
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03029 Mitochondrial biogenesis [BR:tle03029]
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09183 Protein families: signaling and cellular processes
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09185 Viral protein families
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09184 RNA family
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09190 Not Included in Pathway or Brite
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KEGG Orthology (KO) - Pseudothermotoga lettingae