phytochemical cluster No. 53 (1 metabolites)
Plant Species
Cumulative plant class count
| class name | count |
|---|---|
| Liliopsida | 1 |
| rosids | 1 |
Cumulative family count
| class name | count |
|---|---|
| Arecaceae | 1 |
| Lythraceae | 1 |
KEGG BRITE br08003
Categories (1)
| br08003 Category | # of metabolite |
|---|---|
| Estrane | 1 |
metabolites link (1)
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|---|---|
| Estrane | C00468 | C00003663 |
KCF-S cluster (1)
| KCF-S ID | # of metabolite |
|---|---|
| No. 7711 | 1 |
Metabolite list (1)
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
KCF-S
cluster |
figure |
|---|---|---|---|---|---|---|---|
|
C00003663
|
Oestrone
|
CHEMBL756
CHEMBL32152 CHEMBL1405 |
D004970
|
132 / 76 / 56 | 51 / 14 | No. 7711 |
|
Human Protein / Gene in interactions
132 ChEMBL Protein in interactions
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | C00003663 | 1 / 0 |
| P14061 | Estradiol 17-beta-dehydrogenase 1 | Enzyme | C00003663 | 0 / 0 |
| P22310 | UDP-glucuronosyltransferase 1-4 | Enzyme | C00003663 | 3 / 0 |
| O75795 | UDP-glucuronosyltransferase 2B17 | Enzyme | C00003663 | 1 / 0 |
| Q9Y6L6 | Solute carrier organic anion transporter family member 1B1 | Electrochemical transporter | C00003663 | 1 / 0 |
| O94956 | Solute carrier organic anion transporter family member 2B1 | Unclassified protein | C00003663 | 0 / 0 |
| Q9HAW8 | UDP-glucuronosyltransferase 1-10 | Enzyme | C00003663 | 0 / 0 |
| P21728 | D(1A) dopamine receptor | Dopamine receptor | C00003663 | 0 / 0 |
| P35354 | Prostaglandin G/H synthase 2 | Oxidoreductase | C00003663 | 0 / 3 |
| Q12809 | Potassium voltage-gated channel subfamily H member 2 | KCNH, Kv10-12.x (Ether-a-go-go) | C00003663 | 2 / 2 |
| P08246 | Neutrophil elastase | S1A | C00003663 | 2 / 1 |
| P33765 | Adenosine receptor A3 | Adenosine receptor | C00003663 | 0 / 0 |
| Q16539 | Mitogen-activated protein kinase 14 | p38 | C00003663 | 0 / 0 |
| P49146 | Neuropeptide Y receptor type 2 | Neuropeptide Y receptor | C00003663 | 0 / 0 |
| P29466 | Caspase-1 | C14 | C00003663 | 0 / 0 |
| P17252 | Protein kinase C alpha type | Alpha | C00003663 | 0 / 0 |
| P27361 | Mitogen-activated protein kinase 3 | Erk | C00003663 | 0 / 0 |
| P14780 | Matrix metalloproteinase-9 | M10A | C00003663 | 2 / 2 |
| P02545 | Prelamin-A/C | Unclassified protein | C00003663 | 11 / 10 |
| P00918 | Carbonic anhydrase 2 | Lyase | C00003663 | 1 / 2 |
| P07550 | Beta-2 adrenergic receptor | Adrenergic receptor | C00003663 | 0 / 1 |
| P21397 | Amine oxidase [flavin-containing] A | Oxidoreductase | C00003663 | 1 / 1 |
| P25021 | Histamine H2 receptor | Histamine receptor | C00003663 | 0 / 0 |
| P35367 | Histamine H1 receptor | Histamine receptor | C00003663 | 0 / 0 |
| Q01959 | Sodium-dependent dopamine transporter | Dopamine | C00003663 | 1 / 0 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | C00003663 | 0 / 0 |
| P18825 | Alpha-2C adrenergic receptor | Adrenergic receptor | C00003663 | 0 / 0 |
| P13945 | Beta-3 adrenergic receptor | Adrenergic receptor | C00003663 | 0 / 0 |
| P08842 | Steryl-sulfatase | Enzyme | C00003663 | 1 / 1 |
| P08183 | Multidrug resistance protein 1 | drug | C00003663 | 1 / 0 |
| P25024 | C-X-C chemokine receptor type 1 | CXC chemokine receptor | C00003663 | 0 / 0 |
| P06241 | Tyrosine-protein kinase Fyn | Src | C00003663 | 0 / 0 |
| Q08209 | Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform | Ser_Thr | C00003663 | 0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | C00003663 | 0 / 1 |
| P16662 | UDP-glucuronosyltransferase 2B7 | Enzyme | C00003663 | 0 / 0 |
| P07237 | Protein disulfide-isomerase | Enzyme | C00003663 | 0 / 0 |
| P54132 | Bloom syndrome protein | Enzyme | C00003663 | 1 / 2 |
| Q9HAW7 | UDP-glucuronosyltransferase 1-7 | Enzyme | C00003663 | 0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | C00003663 | 1 / 8 |
| P14416 | D(2) dopamine receptor | Dopamine receptor | C00003663 | 2 / 0 |
| P23219 | Prostaglandin G/H synthase 1 | Oxidoreductase | C00003663 | 0 / 0 |
| P37288 | Vasopressin V1a receptor | Vasopressin and oxytocin receptor | C00003663 | 0 / 0 |
| P41145 | Kappa-type opioid receptor | Opioid receptor | C00003663 | 0 / 0 |
| Q9Y271 | Cysteinyl leukotriene receptor 1 | Leukotriene receptor | C00003663 | 0 / 0 |
| P29274 | Adenosine receptor A2a | Adenosine receptor | C00003663 | 0 / 0 |
| Q06520 | Bile salt sulfotransferase | Enzyme | C00003663 | 0 / 0 |
| P25929 | Neuropeptide Y receptor type 1 | Neuropeptide Y receptor | C00003663 | 0 / 0 |
| P50052 | Type-2 angiotensin II receptor | Angiotensin receptor | C00003663 | 1 / 1 |
| P17948 | Vascular endothelial growth factor receptor 1 | Vegfr | C00003663 | 0 / 0 |
| P41968 | Melanocortin receptor 3 | Melanocortin receptor | C00003663 | 1 / 0 |
| P04278 | Sex hormone-binding globulin | Secreted protein | C00003663 | 0 / 0 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | C00003663 | 0 / 0 |
| Q16665 | Hypoxia-inducible factor 1-alpha | Transcription Factor | C00003663 | 0 / 0 |
| O75496 | Geminin | Unclassified protein | C00003663 | 0 / 0 |
| O60656 | UDP-glucuronosyltransferase 1-9 | Enzyme | C00003663 | 0 / 0 |
| P54855 | UDP-glucuronosyltransferase 2B15 | Enzyme | C00003663 | 0 / 0 |
| P04035 | 3-hydroxy-3-methylglutaryl-coenzyme A reductase | Oxidoreductase | C00003663 | 0 / 0 |
| P08913 | Alpha-2A adrenergic receptor | Adrenergic receptor | C00003663 | 0 / 0 |
| P21917 | D(4) dopamine receptor | Dopamine receptor | C00003663 | 0 / 0 |
| P30988 | Calcitonin receptor | Calcitonin receptor | C00003663 | 0 / 0 |
| P35462 | D(3) dopamine receptor | Dopamine receptor | C00003663 | 1 / 0 |
| P41143 | Delta-type opioid receptor | Opioid receptor | C00003663 | 0 / 0 |
| Q92731 | Estrogen receptor beta | NR3A2 | C00003663 | 0 / 1 |
| P41595 | 5-hydroxytryptamine receptor 2B | Serotonin receptor | C00003663 | 0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | C00003663 | 0 / 0 |
| P30411 | B2 bradykinin receptor | Bradykinin receptor | C00003663 | 0 / 0 |
| P32245 | Melanocortin receptor 4 | Melanocortin receptor | C00003663 | 1 / 0 |
| P32238 | Cholecystokinin receptor type A | Cholecystokinin receptor | C00003663 | 0 / 0 |
| P08311 | Cathepsin G | S1A | C00003663 | 0 / 0 |
| Q99720 | Sigma non-opioid intracellular receptor 1 | Membrane receptor | C00003663 | 1 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | C00003663 | 0 / 0 |
| P03956 | Interstitial collagenase | M10A | C00003663 | 0 / 1 |
| P32241 | Vasoactive intestinal polypeptide receptor 1 | Vasoactive intestinal peptide receptor | C00003663 | 0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | C00003663 | 0 / 0 |
| O75897 | Sulfotransferase 1C4 | Enzyme | C00003663 | 0 / 0 |
| P04150 | Glucocorticoid receptor | NR3C1 | C00003663 | 0 / 1 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | C00003663 | 2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | C00003663 | 0 / 0 |
| P21554 | Cannabinoid receptor 1 | Cannabinoid receptor | C00003663 | 0 / 0 |
| P31645 | Sodium-dependent serotonin transporter | Serotonin | C00003663 | 2 / 0 |
| P04626 | Receptor tyrosine-protein kinase erbB-2 | TK tyrosine-protein kinase EGFR subfamily | C00003663 | 5 / 9 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | C00003663 | 1 / 0 |
| P21452 | Substance-K receptor | Neurokinin receptor | C00003663 | 0 / 0 |
| P51679 | C-C chemokine receptor type 4 | CC chemokine receptor | C00003663 | 0 / 0 |
| P51681 | C-C chemokine receptor type 5 | CC chemokine receptor | C00003663 | 3 / 0 |
| P50406 | 5-hydroxytryptamine receptor 6 | Serotonin receptor | C00003663 | 0 / 0 |
| P41597 | C-C chemokine receptor type 2 | CC chemokine receptor | C00003663 | 1 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | C00003663 | 0 / 0 |
| P08575 | Receptor-type tyrosine-protein phosphatase C | Enzyme | C00003663 | 2 / 1 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | C00003663 | 0 / 0 |
| Q99714 | 3-hydroxyacyl-CoA dehydrogenase type-2 | Enzyme | C00003663 | 3 / 3 |
| Q9UNQ0 | ATP-binding cassette sub-family G member 2 | ATP binding cassette | C00003663 | 2 / 0 |
| Q01453 | Peripheral myelin protein 22 | Unclassified protein | C00003663 | 5 / 2 |
| Q96QE3 | ATPase family AAA domain-containing protein 5 | Unclassified protein | C00003663 | 0 / 0 |
| Q9BR01 | Sulfotransferase 4A1 | Enzyme | C00003663 | 0 / 0 |
| Q9HAW9 | UDP-glucuronosyltransferase 1-8 | Enzyme | C00003663 | 0 / 0 |
| Q9Y4X1 | UDP-glucuronosyltransferase 2A1 | Enzyme | C00003663 | 0 / 0 |
| P06133 | UDP-glucuronosyltransferase 2B4 | Enzyme | C00003663 | 0 / 0 |
| O76074 | cGMP-specific 3',5'-cyclic phosphodiesterase | PDE_5A | C00003663 | 0 / 0 |
| P03372 | Estrogen receptor | NR3A1 | C00003663 | 1 / 1 |
| P08588 | Beta-1 adrenergic receptor | Adrenergic receptor | C00003663 | 1 / 0 |
| P22303 | Acetylcholinesterase | Hydrolase | C00003663 | 1 / 0 |
| P28223 | 5-hydroxytryptamine receptor 2A | Serotonin receptor | C00003663 | 0 / 0 |
| P28335 | 5-hydroxytryptamine receptor 2C | Serotonin receptor | C00003663 | 0 / 0 |
| P35372 | Mu-type opioid receptor | Opioid receptor | C00003663 | 0 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | C00003663 | 0 / 0 |
| P25103 | Substance-P receptor | Neurokinin receptor | C00003663 | 0 / 0 |
| P25105 | Platelet-activating factor receptor | PAF receptor | C00003663 | 0 / 0 |
| P08185 | Corticosteroid-binding globulin | Secreted protein | C00003663 | 1 / 1 |
| P33032 | Melanocortin receptor 5 | Melanocortin receptor | C00003663 | 0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | C00003663 | 0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | C00003663 | 1 / 1 |
| P37059 | Estradiol 17-beta-dehydrogenase 2 | Enzyme | C00003663 | 0 / 0 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | C00003663 | 0 / 1 |
| P05181 | Cytochrome P450 2E1 | Cytochrome P450 2E1 | C00003663 | 0 / 0 |
| Q9UNA4 | DNA polymerase iota | Enzyme | C00003663 | 0 / 0 |
| P22309 | UDP-glucuronosyltransferase 1-1 | Enzyme | C00003663 | 5 / 1 |
| P10636 | Microtubule-associated protein tau | Unclassified protein | C00003663 | 4 / 3 |
| P19224 | UDP-glucuronosyltransferase 1-6 | Enzyme | C00003663 | 0 / 0 |
| Q53GQ0 | Estradiol 17-beta-dehydrogenase 12 | Enzyme | C00003663 | 0 / 0 |
| Q16236 | Nuclear factor erythroid 2-related factor 2 | Unclassified protein | C00003663 | 0 / 0 |
| P10275 | Androgen receptor | NR3C4 | C00003663 | 3 / 4 |
| P23975 | Sodium-dependent noradrenaline transporter | Norepinephrine | C00003663 | 1 / 1 |
| P25100 | Alpha-1D adrenergic receptor | Adrenergic receptor | C00003663 | 0 / 0 |
| P30542 | Adenosine receptor A1 | Adenosine receptor | C00003663 | 0 / 0 |
| P18089 | Alpha-2B adrenergic receptor | Adrenergic receptor | C00003663 | 0 / 0 |
| P24557 | Thromboxane-A synthase | Cytochrome P450 5A1 | C00003663 | 1 / 1 |
| P06239 | Tyrosine-protein kinase Lck | Src | C00003663 | 0 / 1 |
| P25025 | C-X-C chemokine receptor type 2 | CXC chemokine receptor | C00003663 | 0 / 0 |
| P49888 | Estrogen sulfotransferase | Enzyme | C00003663 | 0 / 0 |
| P56937 | 3-keto-steroid reductase | Enzyme | C00003663 | 0 / 0 |
| Q13148 | TAR DNA-binding protein 43 | Unclassified protein | C00003663 | 1 / 1 |
51 Gene in CTD interactions
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 5243 | ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1 | ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) |
C00003663
|
| 9429 | ABCG2, ABC15, ABCP, BCRP, BCRP1, BMDP, CD338, CDw338, EST157481, GOUT1, MRX, MXR, MXR1, UAQTL1 | ATP-binding cassette, sub-family G (WHITE), member 2 |
C00003663
|
| 8644 | AKR1C3, DD3, DDX, HA1753, HAKRB, HAKRe, HSD17B5, PGFS, hluPGFS | aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) |
C00003663
|
| 207 | AKT1, AKT, CWS6, PKB, PKB-ALPHA, PRKBA, RAC, RAC-ALPHA | v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) |
C00003663
|
| 250 | ALPP, ALP, PALP, PLAP, PLAP-1 | alkaline phosphatase, placental (EC:3.1.3.1) |
C00003663
|
| 367 | AR, AIS, DHTR, HUMARA, HYSP1, KD, NR3C4, SBMA, SMAX1, TFM | androgen receptor |
C00003663
|
| 396 | ARHGDIA, GDIA1, NPHS8, RHOGDI, RHOGDI-1 | Rho GDP dissociation inhibitor (GDI) alpha |
C00003663
|
| 836 | CASP3, CPP32, CPP32B, SCA-1 | caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) |
C00003663
|
| 840 | CASP7, CASP-7, CMH-1, ICE-LAP3, LICE2, MCH3 | caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) |
C00003663
|
| 1312 | COMT | catechol-O-methyltransferase (EC:2.1.1.6) |
C00003663
|
| 1586 | CYP17A1, CPT7, CYP17, P450C17, S17AH | cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) |
C00003663
|
| 1588 | CYP19A1, ARO, ARO1, CPV1, CYAR, CYP19, CYPXIX, P-450AROM | cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00003663
|
| 1543 | CYP1A1, AHH, AHRR, CP11, CYP1, P1-450, P450-C, P450DX | cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) |
C00003663
|
| 1544 | CYP1A2, CP12, P3-450, P450(PA) | cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) |
C00003663
|
| 1545 | CYP1B1, CP1B, CYPIB1, GLC3A, P4501B1 | cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) |
C00003663
|
| 1576 | CYP3A4, CP33, CP34, CYP3A, CYP3A3, CYPIIIA3, CYPIIIA4, HLP, NF-25, P450C3, P450PCN1 | cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) |
C00003663
|
| 1551 | CYP3A7, CP37, CYPIIIA7, P450-HFLA | cytochrome P450, family 3, subfamily A, polypeptide 7 (EC:1.14.14.1) |
C00003663
|
| 1960 | EGR3, EGR-3, PILOT | early growth response 3 |
C00003663
|
| 2026 | ENO2, NSE | enolase 2 (gamma, neuronal) (EC:4.2.1.11) |
C00003663
|
| 2099 | ESR1, ER, ESR, ESRA, ESTRR, Era, NR3A1 | estrogen receptor 1 |
C00003663
|
| 2100 | ESR2, ER-BETA, ESR-BETA, ESRB, ESTRB, Erb, NR3A2 | estrogen receptor 2 (ER beta) |
C00003663
|
| 3292 | HSD17B1, EDH17B2, EDHB17, HSD17, SDR28C1 | hydroxysteroid (17-beta) dehydrogenase 1 (EC:1.1.1.62) |
C00003663
|
| 51144 | HSD17B12, KAR, SDR12C1 | hydroxysteroid (17-beta) dehydrogenase 12 (EC:1.1.1.62) |
C00003663
|
| 3294 | HSD17B2, EDH17B2, HSD17, SDR9C2 | hydroxysteroid (17-beta) dehydrogenase 2 (EC:1.1.1.62 1.1.1.239) |
C00003663
|
| 3295 | HSD17B4, DBP, MFE-2, MPF-2, PRLTS1, SDR8C1 | hydroxysteroid (17-beta) dehydrogenase 4 (EC:4.2.1.107 4.2.1.119 1.1.1.n12) |
C00003663
|
| 51478 | HSD17B7, PRAP, SDR37C1 | hydroxysteroid (17-beta) dehydrogenase 7 (EC:1.1.1.62 1.1.1.270) |
C00003663
|
| 5594 | MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk | mitogen-activated protein kinase 1 (EC:2.7.11.24) |
C00003663
|
| 5595 | MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK | mitogen-activated protein kinase 3 (EC:2.7.11.24) |
C00003663
|
| 8202 | NCOA3, ACTR, AIB-1, AIB1, CAGH16, CTG26, KAT13B, RAC3, SRC-3, SRC3, TNRC14, TNRC16, TRAM-1, bHLHe42, pCIP | nuclear receptor coactivator 3 (EC:2.3.1.48) |
C00003663
|
| 5154 | PDGFA, PDGF-A, PDGF1 | platelet-derived growth factor alpha polypeptide |
C00003663
|
| 5174 | PDZK1, CAP70, CLAMP, NHERF-3, NHERF3, PDZD1 | PDZ domain containing 1 |
C00003663
|
| 5241 | PGR, NR3C3, PR | progesterone receptor |
C00003663
|
| 6286 | S100P, MIG9 | S100 calcium binding protein P |
C00003663
|
| 8991 | SELENBP1, LPSB, SBP56, SP56, hSBP | selenium binding protein 1 |
C00003663
|
| 6558 | SLC12A2, BSC, BSC2, NKCC1 | solute carrier family 12 (sodium/potassium/chloride transporter), member 2 |
C00003663
|
| 23657 | SLC7A11, CCBR1, xCT | solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 |
C00003663
|
| 412 | STS, ARSC, ARSC1, ASC, ES, SSDD, XLI | steroid sulfatase (microsomal), isozyme S (EC:3.1.6.2) |
C00003663
|
| 6818 | SULT1A3, HAST, HAST3, M-PST, ST1A3/ST1A4, ST1A5, STM, TL-PST | sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) |
C00003663
|
| 6783 | SULT1E1, EST, EST-1, ST1E1, STE | sulfotransferase family 1E, estrogen-preferring, member 1 (EC:2.8.2.4) |
C00003663
|
| 25830 | SULT4A1, BR-STL-1, BRSTL1, DJ388M5.3, NST, SULTX3, hBR-STL-1 | sulfotransferase family 4A, member 1 (EC:2.8.2.-) |
C00003663
|
| 7031 | TFF1, BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2 | trefoil factor 1 |
C00003663
|
| 7124 | TNF, DIF, TNF-alpha, TNFA, TNFSF2 | tumor necrosis factor |
C00003663
|
| 54658 | UGT1A1, BILIQTL1, GNT1, HUG-BR1, UDPGT, UDPGT_1-1, UGT1, UGT1A | UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) |
C00003663
|
| 54575 | UGT1A10, UDPGT, UGT-1J, UGT1-10, UGT1.10, UGT1J | UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) |
C00003663
|
| 54659 | UGT1A3, UDPGT, UDPGT_1-3, UGT-1C, UGT1-03, UGT1.3, UGT1C | UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) |
C00003663
|
| 54577 | UGT1A7, UDPGT, UDPGT_1-7, UGT-1G, UGT1-07, UGT1.7, UGT1G | UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) |
C00003663
|
| 54576 | UGT1A8, UDPGT, UDPGT_1-8, UGT-1H, UGT1-08, UGT1.8, UGT1A8S, UGT1H | UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) |
C00003663
|
| 54600 | UGT1A9, HLUGP4, LUGP4, UDPGT, UDPGT_1-9, UGT-1I, UGT1-09, UGT1-9, UGT1.9, UGT1AI, UGT1I | UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) |
C00003663
|
| 7364 | UGT2B7, UDPGT_2B9, UDPGT2B7, UDPGTH2, UGT2B9 | UDP glucuronosyltransferase 2 family, polypeptide B7 (EC:2.4.1.17) |
C00003663
|
| 7453 | WARS, GAMMA-2, IFI53, IFP53 | tryptophanyl-tRNA synthetase (EC:6.1.1.2) |
C00003663
|
| 331 | XIAP, API3, BIRC4, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3 | X-linked inhibitor of apoptosis |
C00003663
|
Related Diseases
Diseases related to proteins in ChEMBL interactions
OMIM (76)
| OMIM | preferred title | UniProt |
|---|---|---|
| #300438 | 17-beta-hydroxysteroid dehydrogenase x deficiency |
Q99714
|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #103780 | Alcohol dependence |
P08172
P14416 P31645 |
| #612069 | Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 |
Q13148
|
| #614373 | Amyotrophic lateral sclerosis 16, juvenile; als16 |
Q99720
|
| #300068 | Androgen insensitivity syndrome; ais |
P10275
|
| #312300 | Androgen insensitivity, partial; pais |
P10275
|
| #601816 | Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 |
P22309
|
| #614490 | Blood group, junior system; jr |
Q9UNQ0
|
| #210900 | Bloom syndrome; blm |
P54132
|
| #602025 | Body mass index quantitative trait locus 9; bmiq9 |
P41968
|
| #612560 | Bone mineral density quantitative trait locus 12; bmnd12 |
O75795
|
| #300615 | Brunner syndrome |
P21397
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #118300 | Charcot-marie-tooth disease and deafness |
Q01453
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #118220 | Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a |
Q01453
|
| #611489 | Corticosteroid-binding globulin deficiency |
P08185
|
| #218800 | Crigler-najjar syndrome, type i |
P22309
P22310 |
| #606785 | Crigler-najjar syndrome, type ii |
P22309
P22310 |
| #162800 | Cyclic neutropenia |
P08246
|
| #612522 | Diabetes mellitus, insulin-dependent, 22; iddm22 |
P51681
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #615363 | Estrogen resistance; estrr |
P03372
|
| #600274 | Frontotemporal dementia; ftd |
P10636
|
| #613659 | Gastric cancer |
P04626
|
| #137215 | Gastric cancer, hereditary diffuse; hdgc |
P04626
|
| #231095 | Ghosal hematodiaphyseal dysplasia; ghdd |
P24557
|
| #143500 | Gilbert syndrome |
P22309
P22310 |
| #137800 | Glioma susceptibility 1; glm1 |
P04626
|
| #139393 | Guillain-barre syndrome, familial; gbs |
Q01453
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #609423 | Human immunodeficiency virus type 1, susceptibility to |
P41597
P51681 |
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #237450 | Hyperbilirubinemia, rotor type; hblrr |
Q9Y6L6
|
| #237900 | Hyperbilirubinemia, transient familial neonatal; hblrtfn |
P22309
|
| #145900 | Hypertrophic neuropathy of dejerine-sottas |
Q01453
|
| #308100 | Ichthyosis, x-linked; xli |
P08842
|
| #612244 | Inflammatory bowel disease 13; ibd13 |
P08183
|
| #603932 | Intervertebral disc disease; idd |
P14780
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #613688 | Long qt syndrome 2; lqt2 |
Q12809
|
| #211980 | Lung cancer |
P00533
P04626 |
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #300705 | Mental retardation, x-linked 17; mrx17 |
Q99714
|
| %300852 | Mental retardation, x-linked 88; mrx88 |
P50052
|
| #300220 | Mental retardation, x-linked, syndromic 10; mrxs10 |
Q99714
|
| #613073 | Metaphyseal anadysplasia 2; mandp2 |
P14780
|
| #126200 | Multiple sclerosis, susceptibility to; ms |
P08575
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #159900 | Myoclonic dystonia |
P14416
|
| #162500 | Neuropathy, hereditary, with liability to pressure palsies; hnpp |
Q01453
|
| #202700 | Neutropenia, severe congenital, 1, autosomal dominant; scn1 |
P08246
|
| #601665 | Obesity |
P32245
|
| #164230 | Obsessive-compulsive disorder; ocd |
P31645
|
| #604715 | Orthostatic intolerance |
P23975
|
| #259730 | Osteopetrosis, autosomal recessive 3; optb3 |
P00918
|
| #167000 | Ovarian cancer |
P04626
|
| #260540 | Parkinson-dementia syndrome |
P10636
|
| #613135 | Parkinsonism-dystonia, infantile; pkdys |
Q01959
|
| #172700 | Pick disease of brain |
P10636
|
| #607276 | Resting heart rate, variation in |
P08588
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #608971 | Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive |
P08575
|
| #609620 | Short qt syndrome 1; sqt1 |
Q12809
|
| #313200 | Spinal and bulbar muscular atrophy, x-linked 1; smax1 |
P10275
|
| #601104 | Supranuclear palsy, progressive, 1; psnp1 |
P10636
|
| #190300 | Tremor, hereditary essential, 1; etm1 |
P35462
|
| #138900 | Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 |
Q9UNQ0
|
| #610379 | West nile virus, susceptibility to |
P51681
|
| #112100 | Yt blood group antigen |
P22303
|
KEGG DISEASE (56)
| KEGG | name | UniProt |
|---|---|---|
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
P35354 (related) |
| H00018 | Gastric cancer |
P00533
(related)
P04626 (related) |
| H00022 | Bladder cancer |
P00533
(related)
P04626 (related) |
| H00028 | Choriocarcinoma |
P00533
(related)
P03956 (related) P04626 (related) |
| H00030 | Cervical cancer |
P00533
(related)
P04626 (related) |
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00055 | Laryngeal cancer |
P00533
(related)
P00533 (marker) |
| H00241 | Combined proximal and distal renal tubular acidosis (RTA type 3) |
P00918
(related)
|
| H00436 | Osteopetrosis |
P00918
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
Q01453 (related) |
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00026 | Endometrial Cancer |
P03372
(marker)
P04626 (related) Q92731 (marker) |
| H00599 | 46,XX disorders of sex development (Disorders related to androgen excess) |
P04150
(related)
|
| H00019 | Pancreatic cancer |
P04626
(related)
|
| H00027 | Ovarian cancer |
P04626
(related)
|
| H00031 | Breast cancer |
P04626
(related)
P04626 (marker) |
| H00046 | Cholangiocarcinoma |
P04626
(related)
P35354 (related) |
| H00093 | Combined immunodeficiencies (CIDs) |
P06239
(related)
|
| H00079 | Asthma |
P07550
(related)
|
| H01163 | Corticosteroid-binding globulin (CBG) deficiency |
P08185
(related)
|
| H00100 | Neutropenic disorders |
P08246
(related)
|
| H00091 | T-B+Severe combined immunodeficiencies (SCIDs) |
P08575
(related)
|
| H00036 | Osteosarcoma |
P08684
(marker)
|
| H00134 | X-linked ichthyosis (XLI) |
P08842
(related)
|
| H00024 | Prostate cancer |
P10275
(related)
|
| H00062 | Spinal and bulbar muscular atrophy (SBMA) |
P10275
(related)
|
| H00608 | 46,XY disorders of sex development (Disorders in androgen synthesis or action) |
P10275
(related)
|
| H00609 | 46,XY disorders of sex development (Other) |
P10275
(related)
|
| H00058 | Amyotrophic lateral sclerosis (ALS) |
P10636
(related)
Q13148 (related) |
| H00077 | Progressive supranuclear palsy (PSP) |
P10636
(related)
|
| H00078 | Frontotemporal lobar degeneration (FTLD) |
P10636
(related)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H00025 | Penile cancer |
P14780
(related)
P35354 (related) |
| H00479 | Metaphyseal dysplasias |
P14780
(related)
|
| H00548 | Brunner syndrome |
P21397
(related)
|
| H00208 | Hyperbilirubinemia |
P22309
(related)
|
| H01031 | Orthostatic intolerance (OI) |
P23975
(related)
|
| H00490 | Diaphyseal dysplasia with anemia (Ghosal) |
P24557
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00480 | Non-syndromic X-linked mental retardation |
P50052
(related)
Q99714 (related) |
| H00094 | DNA repair defects |
P54132
(related)
|
| H00296 | Defects in RecQ helicases |
P54132
(related)
|
| H01296 | Hereditary neuropathy with liability to pressure palsies (HNPP) |
Q01453
(related)
|
| H00720 | Long QT syndrome |
Q12809
(related)
|
| H00725 | Short QT syndrome |
Q12809
(related)
|
| H00658 | Syndromic X-linked mental retardation |
Q99714
(related)
|
| H00925 | 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency |
Q99714
(related)
|
Diseases related to CTD interactions
14 disease in interactions with metabolites
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D000230 | Adenocarcinoma |
C00003663
|
| D000782 | Aneuploidy |
C00003663
|
| D002471 | Cell Transformation, Neoplastic |
C00003663
|
| D019457 | Chromosome Breakage |
C00003663
|
| D006177 | Gynecomastia |
C00003663
|
| D006943 | Hyperglycemia |
C00003663
|
| D006946 | Hyperinsulinism |
C00003663
|
| D007006 | Hypogonadism |
C00003663
|
| D007680 | Kidney Neoplasms |
C00003663
|
| D010182 | Pancreatic Diseases |
C00003663
|
| D010911 | Pituitary Neoplasms |
C00003663
|
| D015175 | Prolactinoma |
C00003663
|
| D011471 | Prostatic Neoplasms |
C00003663
|
| D014625 | Vaginal Neoplasms |
C00003663
|