PCIDB

KNApSAcK Metabolite C00003663

Metabolite

KNApSAcK Entry

id C00003663
Name Oestrone
CAS RN 53-16-7
Standard InChI InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3/t14-,15-,16+,18+/m1/s1
Standard InChI (Main Layer) InChI=1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-16,19H,2,4,6-9H2,1H3

Cluster

Phytochemical cluster No. 53
KCF-S cluster No. 7711

Link

ChEMBL

By standard InChI CHEMBL1405
By standard InChI Main Layer CHEMBL756 CHEMBL32152 CHEMBL1405

KEGG

By LinkDB C00468

CTD

By CAS RN D004970

Species

Summary

Plant class

class name count
Liliopsida 1
rosids 1

Family

family name count
Arecaceae 1
Lythraceae 1

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Phoenix dactylifera 42345 Arecaceae Liliopsida Viridiplantae
Punica granatum 22663 Lythraceae rosids Viridiplantae

Human Protein / Gene in interaction

132 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1405 CHEMBL1741321 (1) CHEMBL1909136 (2)
1 / 0
P14061 Estradiol 17-beta-dehydrogenase 1 Enzyme CHEMBL1405 CHEMBL864128 (1) CHEMBL864130 (1)
CHEMBL914641 (1) CHEMBL914642 (1)
CHEMBL914643 (1) CHEMBL914644 (1)
CHEMBL914645 (1) CHEMBL914646 (1)
CHEMBL914647 (1) CHEMBL914648 (1)
CHEMBL929590 (1) CHEMBL929589 (1)
CHEMBL929591 (1) CHEMBL930592 (1)
CHEMBL930597 (1) CHEMBL1014266 (1)
CHEMBL1013420 (1) CHEMBL1013421 (1)
CHEMBL1102464 (1) CHEMBL1102466 (1)
CHEMBL2208692 (1)
0 / 0
P22310 UDP-glucuronosyltransferase 1-4 Enzyme CHEMBL1405 CHEMBL1908082 (1)
3 / 0
O75795 UDP-glucuronosyltransferase 2B17 Enzyme CHEMBL1405 CHEMBL1908091 (2)
1 / 0
Q9Y6L6 Solute carrier organic anion transporter family member 1B1 Electrochemical transporter CHEMBL1405 CHEMBL2077601 (1)
1 / 0
O94956 Solute carrier organic anion transporter family member 2B1 Unclassified protein CHEMBL1405 CHEMBL2077320 (1)
0 / 0
Q9HAW8 UDP-glucuronosyltransferase 1-10 Enzyme CHEMBL1405 CHEMBL1908087 (2)
0 / 0
P21728 D(1A) dopamine receptor Dopamine receptor CHEMBL1405 CHEMBL1909139 (2)
0 / 0
P35354 Prostaglandin G/H synthase 2 Oxidoreductase CHEMBL1405 CHEMBL1909131 (2)
0 / 3
Q12809 Potassium voltage-gated channel subfamily H member 2 KCNH, Kv10-12.x (Ether-a-go-go) CHEMBL1405 CHEMBL1909190 (2)
2 / 2
P08246 Neutrophil elastase S1A CHEMBL1405 CHEMBL1909195 (2)
2 / 1
P33765 Adenosine receptor A3 Adenosine receptor CHEMBL1405 CHEMBL1909215 (2)
0 / 0
Q16539 Mitogen-activated protein kinase 14 p38 CHEMBL1405 CHEMBL1909201 (2)
0 / 0
P49146 Neuropeptide Y receptor type 2 Neuropeptide Y receptor CHEMBL1405 CHEMBL1909176 (2)
0 / 0
P29466 Caspase-1 C14 CHEMBL1405 CHEMBL1909193 (2)
0 / 0
P17252 Protein kinase C alpha type Alpha CHEMBL1405 CHEMBL1909198 (2)
0 / 0
P27361 Mitogen-activated protein kinase 3 Erk CHEMBL1405 CHEMBL1909199 (2)
0 / 0
P14780 Matrix metalloproteinase-9 M10A CHEMBL1405 CHEMBL1909197 (2)
2 / 2
P02545 Prelamin-A/C Unclassified protein CHEMBL1405 CHEMBL1614310 (1) CHEMBL1614544 (1)
11 / 10
P00918 Carbonic anhydrase 2 Lyase CHEMBL1405 CHEMBL1909123 (2)
1 / 2
P07550 Beta-2 adrenergic receptor Adrenergic receptor CHEMBL1405 CHEMBL1909092 (2)
0 / 1
P21397 Amine oxidase [flavin-containing] A Oxidoreductase CHEMBL1405 CHEMBL1909169 (2)
1 / 1
P25021 Histamine H2 receptor Histamine receptor CHEMBL1405 CHEMBL1909157 (2)
0 / 0
P35367 Histamine H1 receptor Histamine receptor CHEMBL1405 CHEMBL1909156 (2)
0 / 0
Q01959 Sodium-dependent dopamine transporter Dopamine CHEMBL1405 CHEMBL1909143 (2)
1 / 0
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor CHEMBL1405 CHEMBL1909174 (2)
0 / 0
P18825 Alpha-2C adrenergic receptor Adrenergic receptor CHEMBL1405 CHEMBL1909090 (2)
0 / 0
P13945 Beta-3 adrenergic receptor Adrenergic receptor CHEMBL1405 CHEMBL1909093 (2)
0 / 0
P08842 Steryl-sulfatase Enzyme CHEMBL1405 CHEMBL1839049 (1)
1 / 1
P08183 Multidrug resistance protein 1 drug CHEMBL1405 CHEMBL2078577 (1)
1 / 0
P25024 C-X-C chemokine receptor type 1 CXC chemokine receptor CHEMBL1405 CHEMBL1909127 (2)
0 / 0
P06241 Tyrosine-protein kinase Fyn Src CHEMBL1405 CHEMBL1909204 (2)
0 / 0
Q08209 Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform Ser_Thr CHEMBL1405 CHEMBL1909202 (2)
0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1405 CHEMBL1741325 (1) CHEMBL1909135 (2)
0 / 1
P16662 UDP-glucuronosyltransferase 2B7 Enzyme CHEMBL1405 CHEMBL1908093 (1)
0 / 0
P07237 Protein disulfide-isomerase Enzyme CHEMBL756 CHEMBL2114826 (1)
0 / 0
P54132 Bloom syndrome protein Enzyme CHEMBL1405 CHEMBL1614522 (1) CHEMBL1614067 (1)
1 / 2
Q9HAW7 UDP-glucuronosyltransferase 1-7 Enzyme CHEMBL1405 CHEMBL1908084 (1)
0 / 0
P00533 Epidermal growth factor receptor TK tyrosine-protein kinase EGFR subfamily CHEMBL1405 CHEMBL1909203 (2)
1 / 11
P14416 D(2) dopamine receptor Dopamine receptor CHEMBL1405 CHEMBL1909140 (2)
2 / 0
P23219 Prostaglandin G/H synthase 1 Oxidoreductase CHEMBL1405 CHEMBL1909130 (2)
0 / 0
P37288 Vasopressin V1a receptor Vasopressin and oxytocin receptor CHEMBL1405 CHEMBL1909120 (2)
0 / 0
P41145 Kappa-type opioid receptor Opioid receptor CHEMBL1405 CHEMBL1909181 (2)
0 / 0
Q9Y271 Cysteinyl leukotriene receptor 1 Leukotriene receptor CHEMBL1405 CHEMBL1909164 (2)
0 / 0
P29274 Adenosine receptor A2a Adenosine receptor CHEMBL1405 CHEMBL1909214 (2)
0 / 0
Q06520 Bile salt sulfotransferase Enzyme CHEMBL1405 CHEMBL1743310 (1)
0 / 0
P25929 Neuropeptide Y receptor type 1 Neuropeptide Y receptor CHEMBL1405 CHEMBL1909175 (2)
0 / 0
P50052 Type-2 angiotensin II receptor Angiotensin receptor CHEMBL1405 CHEMBL1909096 (2)
1 / 1
P17948 Vascular endothelial growth factor receptor 1 Vegfr CHEMBL1405 CHEMBL1909118 (2)
0 / 0
P41968 Melanocortin receptor 3 Melanocortin receptor CHEMBL1405 CHEMBL1909166 (2)
1 / 0
P04278 Sex hormone-binding globulin Secreted protein CHEMBL1405 CHEMBL812631 (1) CHEMBL858260 (1)
CHEMBL809266 (1) CHEMBL809276 (1)
CHEMBL922711 (1)
0 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL1405 CHEMBL1909133 (2)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL1405 CHEMBL1614456 (2) CHEMBL1613803 (2)
0 / 0
O75496 Geminin Unclassified protein CHEMBL756 CHEMBL2114780 (1)
0 / 0
O60656 UDP-glucuronosyltransferase 1-9 Enzyme CHEMBL1405 CHEMBL1908086 (1)
0 / 0
P54855 UDP-glucuronosyltransferase 2B15 Enzyme CHEMBL1405 CHEMBL1908090 (1)
0 / 0
P04035 3-hydroxy-3-methylglutaryl-coenzyme A reductase Oxidoreductase CHEMBL1405 CHEMBL1909158 (2)
0 / 0
P08913 Alpha-2A adrenergic receptor Adrenergic receptor CHEMBL1405 CHEMBL1909088 (2)
0 / 0
P21917 D(4) dopamine receptor Dopamine receptor CHEMBL1405 CHEMBL1909142 (2)
0 / 0
P30988 Calcitonin receptor Calcitonin receptor CHEMBL1405 CHEMBL1909101 (2)
0 / 0
P35462 D(3) dopamine receptor Dopamine receptor CHEMBL1405 CHEMBL1909141 (2)
1 / 0
P41143 Delta-type opioid receptor Opioid receptor CHEMBL1405 CHEMBL1909180 (2)
0 / 0
Q92731 Estrogen receptor beta NR3A2 CHEMBL1405 CHEMBL679678 (1) CHEMBL673864 (1)
CHEMBL682160 (1) CHEMBL682162 (1)
CHEMBL682163 (1) CHEMBL682169 (1)
CHEMBL702879 (1) CHEMBL847349 (1)
CHEMBL860987 (1) CHEMBL860991 (1)
CHEMBL860992 (1) CHEMBL860995 (1)
CHEMBL860997 (1) CHEMBL1045064 (1)
CHEMBL1664695 (1) CHEMBL1909146 (2)
0 / 1
P41595 5-hydroxytryptamine receptor 2B Serotonin receptor CHEMBL1405 CHEMBL1909104 (2)
0 / 0
P25101 Endothelin-1 receptor Endothelin receptor CHEMBL1405 CHEMBL1909144 (2)
0 / 0
P30411 B2 bradykinin receptor Bradykinin receptor CHEMBL1405 CHEMBL1909100 (2)
0 / 0
P32245 Melanocortin receptor 4 Melanocortin receptor CHEMBL1405 CHEMBL1909167 (2)
1 / 0
P32238 Cholecystokinin receptor type A Cholecystokinin receptor CHEMBL1405 CHEMBL1909129 (2)
0 / 0
P08311 Cathepsin G S1A CHEMBL1405 CHEMBL1909194 (2)
0 / 0
Q99720 Sigma non-opioid intracellular receptor 1 Membrane receptor CHEMBL1405 CHEMBL1909110 (2)
1 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL756 CHEMBL2114788 (1)
0 / 0
P03956 Interstitial collagenase M10A CHEMBL1405 CHEMBL1909196 (2)
0 / 1
P32241 Vasoactive intestinal polypeptide receptor 1 Vasoactive intestinal peptide receptor CHEMBL1405 CHEMBL1909119 (2)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL1405 CHEMBL1794401 (1)
0 / 0
O75897 Sulfotransferase 1C4 Enzyme CHEMBL1405 CHEMBL1743308 (1)
0 / 0
P04150 Glucocorticoid receptor NR3C1 CHEMBL1405 CHEMBL1909150 (2)
0 / 1
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor CHEMBL1405 CHEMBL1909171 (2)
2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor CHEMBL1405 CHEMBL1909170 (2)
0 / 0
P21554 Cannabinoid receptor 1 Cannabinoid receptor CHEMBL1405 CHEMBL1909122 (2)
0 / 0
P31645 Sodium-dependent serotonin transporter Serotonin CHEMBL1405 CHEMBL1909109 (2)
2 / 0
P04626 Receptor tyrosine-protein kinase erbB-2 TK tyrosine-protein kinase EGFR subfamily CHEMBL1405 CHEMBL1909205 (2)
5 / 10
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor CHEMBL1405 CHEMBL1909172 (2)
1 / 0
P21452 Substance-K receptor Neurokinin receptor CHEMBL1405 CHEMBL1909114 (2)
0 / 0
P51679 C-C chemokine receptor type 4 CC chemokine receptor CHEMBL1405 CHEMBL1909125 (2)
0 / 0
P51681 C-C chemokine receptor type 5 CC chemokine receptor CHEMBL1405 CHEMBL1909126 (2)
3 / 0
P50406 5-hydroxytryptamine receptor 6 Serotonin receptor CHEMBL1405 CHEMBL1909108 (2)
0 / 0
P41597 C-C chemokine receptor type 2 CC chemokine receptor CHEMBL1405 CHEMBL1909124 (2)
1 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL1405 CHEMBL1909200 (2)
0 / 0
P08575 Receptor-type tyrosine-protein phosphatase C Enzyme CHEMBL1405 CHEMBL1909207 (2)
2 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1405 CHEMBL1741322 (1) CHEMBL1909132 (2)
0 / 0
Q99714 3-hydroxyacyl-CoA dehydrogenase type-2 Enzyme CHEMBL1405 CHEMBL1614227 (2)
3 / 3
Q9UNQ0 ATP-binding cassette sub-family G member 2 ATP binding cassette CHEMBL1405 CHEMBL1743177 (1) CHEMBL2077079 (1)
CHEMBL2077080 (1) CHEMBL2077540 (1)
CHEMBL2076473 (1) CHEMBL2075599 (1)
CHEMBL2075605 (1) CHEMBL2075606 (1)
CHEMBL2076243 (1) CHEMBL2076053 (1)
CHEMBL2078552 (1)
2 / 0
Q01453 Peripheral myelin protein 22 Unclassified protein CHEMBL1405 CHEMBL1614171 (1)
5 / 2
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL756 CHEMBL1405 CHEMBL1738588 (1) CHEMBL1738317 (1)
0 / 0
Q9BR01 Sulfotransferase 4A1 Enzyme CHEMBL1405 CHEMBL1743313 (1)
0 / 0
Q9HAW9 UDP-glucuronosyltransferase 1-8 Enzyme CHEMBL1405 CHEMBL1908085 (2)
0 / 0
Q9Y4X1 UDP-glucuronosyltransferase 2A1 Enzyme CHEMBL1405 CHEMBL1908088 (1)
0 / 0
P06133 UDP-glucuronosyltransferase 2B4 Enzyme CHEMBL1405 CHEMBL1908092 (3)
0 / 0
O76074 cGMP-specific 3',5'-cyclic phosphodiesterase PDE_5A CHEMBL1405 CHEMBL1909186 (2)
0 / 0
P03372 Estrogen receptor NR3A1 CHEMBL1405 CHEMBL679678 (1) CHEMBL676806 (1)
CHEMBL883442 (1) CHEMBL676811 (1)
CHEMBL676812 (1) CHEMBL676819 (1)
CHEMBL702879 (1) CHEMBL847349 (1)
CHEMBL860989 (1) CHEMBL860991 (1)
CHEMBL860997 (1) CHEMBL1045063 (1)
CHEMBL1102465 (1) CHEMBL1664694 (1)
CHEMBL1794364 (1) CHEMBL1909145 (2)
1 / 1
P08588 Beta-1 adrenergic receptor Adrenergic receptor CHEMBL1405 CHEMBL1909091 (2)
1 / 0
P22303 Acetylcholinesterase Hydrolase CHEMBL1405 CHEMBL1909212 (2)
1 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL1405 CHEMBL1909211 (2)
0 / 0
P28335 5-hydroxytryptamine receptor 2C Serotonin receptor CHEMBL1405 CHEMBL1909105 (2)
0 / 0
P35372 Mu-type opioid receptor Opioid receptor CHEMBL1405 CHEMBL1909182 (2)
0 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor CHEMBL1405 CHEMBL1909173 (2)
0 / 0
P25103 Substance-P receptor Neurokinin receptor CHEMBL1405 CHEMBL1909113 (2)
0 / 0
P25105 Platelet-activating factor receptor PAF receptor CHEMBL1405 CHEMBL1909187 (2)
0 / 0
P08185 Corticosteroid-binding globulin Secreted protein CHEMBL1405 CHEMBL665988 (1) CHEMBL665989 (1)
CHEMBL665992 (1) CHEMBL665994 (1)
CHEMBL665995 (1) CHEMBL840929 (1)
CHEMBL665996 (1) CHEMBL665997 (1)
1 / 1
P33032 Melanocortin receptor 5 Melanocortin receptor CHEMBL1405 CHEMBL1909168 (2)
0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL1405 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1405 CHEMBL1741323 (1) CHEMBL1909134 (2)
1 / 1
P37059 Estradiol 17-beta-dehydrogenase 2 Enzyme CHEMBL1405 CHEMBL864129 (1)
0 / 0
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1405 CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL1741324 (1) CHEMBL1909138 (2)
0 / 1
P05181 Cytochrome P450 2E1 Cytochrome P450 2E1 CHEMBL1405 CHEMBL1909137 (2)
0 / 0
Q9UNA4 DNA polymerase iota Enzyme CHEMBL1405 CHEMBL1794483 (1)
0 / 0
P22309 UDP-glucuronosyltransferase 1-1 Enzyme CHEMBL1405 CHEMBL1908080 (2)
5 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL32152 CHEMBL1614421 (1)
4 / 3
P19224 UDP-glucuronosyltransferase 1-6 Enzyme CHEMBL1405 CHEMBL1908083 (1)
0 / 0
Q53GQ0 Estradiol 17-beta-dehydrogenase 12 Enzyme CHEMBL1405 CHEMBL914651 (1) CHEMBL914652 (1)
0 / 0
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL1405 CHEMBL1737980 (1)
0 / 0
P10275 Androgen receptor NR3C4 CHEMBL1405 CHEMBL1794560 (1)
3 / 4
P23975 Sodium-dependent noradrenaline transporter Norepinephrine CHEMBL1405 CHEMBL1909094 (2)
1 / 1
P25100 Alpha-1D adrenergic receptor Adrenergic receptor CHEMBL1405 CHEMBL1909087 (2)
0 / 0
P30542 Adenosine receptor A1 Adenosine receptor CHEMBL1405 CHEMBL1909213 (2)
0 / 0
P18089 Alpha-2B adrenergic receptor Adrenergic receptor CHEMBL1405 CHEMBL1909089 (2)
0 / 0
P24557 Thromboxane-A synthase Cytochrome P450 5A1 CHEMBL1405 CHEMBL1909116 (2)
1 / 1
P06239 Tyrosine-protein kinase Lck Src CHEMBL1405 CHEMBL1909206 (2)
0 / 1
P25025 C-X-C chemokine receptor type 2 CXC chemokine receptor CHEMBL1405 CHEMBL1909128 (2)
0 / 0
P49888 Estrogen sulfotransferase Enzyme CHEMBL1405 CHEMBL1743309 (2)
0 / 0
P56937 3-keto-steroid reductase Enzyme CHEMBL1405 CHEMBL914649 (1) CHEMBL914650 (1)
CHEMBL1106724 (1) CHEMBL1106725 (1)
0 / 0
Q13148 TAR DNA-binding protein 43 Unclassified protein CHEMBL1405 CHEMBL2354287 (1)
1 / 1

CTD interaction (98)

compound gene gene name gene description interaction interaction type form reference
pmid
D004970 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) ABCB1 protein results in increased export of Estrone increases export
protein 15290871
D004970 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Elacridar inhibits the reaction [ABCB1 protein results in increased export of Estrone] decreases reaction
/ increases export
protein 15290871
D004970 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Estrone results in decreased expression of ABCB1 protein decreases expression
protein 16925584
D004970 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Estrone results in increased expression of ABCB1 mRNA increases expression
mRNA 15290871
D004970 5243 ABCB1
ABC20
CD243
CLCS
GP170
MDR1
P-GP
PGY1
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) Estrone results in increased expression of ABCB1 protein increases expression
protein 15290871
D004970 9429 ABCG2
ABC15
ABCP
BCRP
BCRP1
BMDP
CD338
CDw338
EST157481
GOUT1
MRX
MXR
MXR1
UAQTL1
ATP-binding cassette, sub-family G (WHITE), member 2 Estrone results in increased expression of ABCG2 mRNA increases expression
mRNA 16849015
D004970 8644 AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) AKR1C3 protein results in increased metabolism of Estrone increases metabolic processing
protein 19010312
D004970 8644 AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) [AKR1C3 protein results in increased metabolism of Estrone] which results in increased chemical synthesis of Estradiol increases chemical synthesis
/ increases metabolic processing
protein 19010312
D004970 8644 AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) AKR1C3 protein results in increased reduction of Estrone increases reduction
protein 20036328
D004970 8644 AKR1C3
DD3
DDX
HA1753
HAKRB
HAKRe
HSD17B5
PGFS
hluPGFS
aldo-keto reductase family 1, member C3 (EC:1.3.1.20 1.1.1.188 1.1.1.239 1.1.1.64 1.1.1.112 1.1.1.357) [AKR1C3 protein results in increased reduction of Estrone] which results in increased chemical synthesis of Estradiol increases chemical synthesis
/ increases reduction
protein 20036328
D004970 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) Estrone results in increased phosphorylation of AKT1 protein increases phosphorylation
protein 21767602
D004970 207 AKT1
AKT
CWS6
PKB
PKB-ALPHA
PRKBA
RAC
RAC-ALPHA
v-akt murine thymoma viral oncogene homolog 1 (EC:2.7.11.1) wortmannin inhibits the reaction [Estrone results in increased phosphorylation of AKT1 protein] decreases reaction
/ increases phosphorylation
protein 21767602
D004970 250 ALPP
ALP
PALP
PLAP
PLAP-1
alkaline phosphatase, placental (EC:3.1.3.1) ALPP protein results in increased chemical synthesis of Estrone increases chemical synthesis
protein 1495895
D004970 367 AR
AIS
DHTR
HUMARA
HYSP1
KD
NR3C4
SBMA
SMAX1
TFM
androgen receptor Estrone binds to and results in increased activity of AR protein affects binding
/ increases activity
protein 12676605
D004970 396 ARHGDIA
GDIA1
NPHS8
RHOGDI
RHOGDI-1
Rho GDP dissociation inhibitor (GDI) alpha Estrone results in decreased expression of ARHGDIA mRNA decreases expression
mRNA 15159206
D004970 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Estrone results in increased activity of CASP3 protein increases activity
protein 22700542
D004970 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Palmitic Acid promotes the reaction [Estrone results in increased activity of CASP3 protein] increases activity
/ increases reaction
protein 22700542
D004970 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Estrone results in increased activity of CASP7 protein increases activity
protein 22700542
D004970 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Palmitic Acid promotes the reaction [Estrone results in increased activity of CASP7 protein] increases activity
/ increases reaction
protein 22700542
D004970 1312 COMT
catechol-O-methyltransferase (EC:2.1.1.6) COMT protein results in increased methylation of Estrone metabolite increases methylation
protein 22285433
D004970 1586 CYP17A1
CPT7
CYP17
P450C17
S17AH
cytochrome P450, family 17, subfamily A, polypeptide 1 (EC:1.14.99.9 4.1.2.30) CYP17A1 protein affects the abundance of Estrone affects abundance
protein 21427057
D004970 1588 CYP19A1
ARO
ARO1
CPV1
CYAR
CYP19
CYPXIX
P-450AROM
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) CYP19A1 protein affects the chemical synthesis of Estrone affects chemical synthesis
protein 16030167
D004970 1588 CYP19A1
ARO
ARO1
CPV1
CYAR
CYP19
CYPXIX
P-450AROM
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) CYP19A1 protein results in increased chemical synthesis of Estrone increases chemical synthesis
protein 16054388
D004970 1588 CYP19A1
ARO
ARO1
CPV1
CYAR
CYP19
CYPXIX
P-450AROM
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) Estrone analog binds to and results in decreased activity of CYP19A1 protein affects binding
/ decreases activity
protein 16039845
D004970 1588 CYP19A1
ARO
ARO1
CPV1
CYAR
CYP19
CYPXIX
P-450AROM
cytochrome P450, family 19, subfamily A, polypeptide 1 (EC:1.14.14.1) TNF protein promotes the reaction [CYP19A1 protein affects the chemical synthesis of Estrone] affects chemical synthesis
/ increases reaction
protein 16030167
D004970 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) CYP1A1 protein polymorphism results in increased hydroxylation of Estrone increases hydroxylation
protein 15805301
D004970 1544 CYP1A2
CP12
P3-450
P450(PA)
cytochrome P450, family 1, subfamily A, polypeptide 2 (EC:1.14.14.1) CYP1A2 protein promotes the reaction [Estrone binds to Deoxyguanosine] affects binding
/ increases reaction
protein 21907773
D004970 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) CYP1B1 protein polymorphism affects the hydroxylation of Estrone affects hydroxylation
protein 16207128
D004970 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) CYP1B1 protein results in increased hydroxylation of Estrone increases hydroxylation
protein 15763594
D004970 1545 CYP1B1
CP1B
CYPIB1
GLC3A
P4501B1
cytochrome P450, family 1, subfamily B, polypeptide 1 (EC:1.14.14.1) Estrone binds to and results in decreased activity of CYP1B1 protein affects binding
/ decreases activity
protein 19563207
D004970 1576 CYP3A4
CP33
CP34
CYP3A
CYP3A3
CYPIIIA3
CYPIIIA4
HLP
NF-25
P450C3
P450PCN1
cytochrome P450, family 3, subfamily A, polypeptide 4 (EC:1.14.13.67 1.14.13.97 1.14.13.32 1.14.13.157) CYP3A4 protein promotes the reaction [Estrone binds to Deoxyguanosine] affects binding
/ increases reaction
protein 21907773
D004970 1551 CYP3A7
CP37
CYPIIIA7
P450-HFLA
cytochrome P450, family 3, subfamily A, polypeptide 7 (EC:1.14.14.1) CYP3A7 promoter polymorphism affects the abundance of Estrone affects abundance
promoter 15985487
D004970 1551 CYP3A7
CP37
CYPIIIA7
P450-HFLA
cytochrome P450, family 3, subfamily A, polypeptide 7 (EC:1.14.14.1) CYP3A7 protein results in increased hydroxylation of Estrone increases hydroxylation
protein 15985487
D004970 1960 EGR3
EGR-3
PILOT
early growth response 3 Estrone results in increased expression of EGR3 mRNA increases expression
mRNA 15159206
D004970 2026 ENO2
NSE
enolase 2 (gamma, neuronal) (EC:4.2.1.11) Estrone results in decreased expression of ENO2 mRNA decreases expression
mRNA 15159206
D004970 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Estrone binds to and results in increased activity of ESR1 protein affects binding
/ increases activity
protein 12676605
D004970 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Estrone binds to ESR1 protein affects binding
protein 11162928
11518614
12598185
19233257
19913605
D004970 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Estrone inhibits the reaction [16 alpha-iodoestradiol binds to ESR1 protein] affects binding
/ decreases reaction
protein 9048584
D004970 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Estrone inhibits the reaction [ESR1 results in increased susceptibility to Cisplatin] decreases reaction
/ increases response to substance
21767602
D004970 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Estrone inhibits the reaction [Estradiol binds to ESR1 protein] affects binding
/ decreases reaction
protein 12127041
D004970 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Estrone promotes the reaction [ESR1 protein alternative form binds to ESR1 protein alternative form] affects binding
/ increases reaction
protein 19233257
D004970 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Estrone promotes the reaction [ESR1 protein binds to ESR1 protein] affects binding
/ increases reaction
protein 18026938
D004970 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 Estrone results in increased activity of ESR1 protein increases activity
protein 11331656
22562034
D004970 2099 ESR1
ER
ESR
ESRA
ESTRR
Era
NR3A1
estrogen receptor 1 fulvestrant inhibits the reaction [Estrone results in increased activity of ESR1 protein] decreases reaction
/ increases activity
protein 22562034
D004970 2100 ESR2
ER-BETA
ESR-BETA
ESRB
ESTRB
Erb
NR3A2
estrogen receptor 2 (ER beta) Estrone binds to ESR2 protein affects binding
protein 11518614
19913605
D004970 3292 HSD17B1
EDH17B2
EDHB17
HSD17
SDR28C1
hydroxysteroid (17-beta) dehydrogenase 1 (EC:1.1.1.62) coumarin analog inhibits the reaction [[HSD17B1 protein co-treated with NADP] results in increased reduction of Estrone] affects cotreatment
/ decreases reaction
/ increases reduction
protein 21232530
D004970 3292 HSD17B1
EDH17B2
EDHB17
HSD17
SDR28C1
hydroxysteroid (17-beta) dehydrogenase 1 (EC:1.1.1.62) HSD17B1 protein affects the metabolism of Estrone affects metabolic processing
protein 16054388
D004970 3292 HSD17B1
EDH17B2
EDHB17
HSD17
SDR28C1
hydroxysteroid (17-beta) dehydrogenase 1 (EC:1.1.1.62) [HSD17B1 protein co-treated with NADP] results in increased reduction of Estrone affects cotreatment
/ increases reduction
protein 21232530
D004970 3292 HSD17B1
EDH17B2
EDHB17
HSD17
SDR28C1
hydroxysteroid (17-beta) dehydrogenase 1 (EC:1.1.1.62) HSD17B1 protein results in increased chemical synthesis of Estrone increases chemical synthesis
protein 16054388
D004970 51144 HSD17B12
KAR
SDR12C1
hydroxysteroid (17-beta) dehydrogenase 12 (EC:1.1.1.62) HSD17B12 protein results in increased metabolism of Estrone increases metabolic processing
protein 16166196
D004970 3294 HSD17B2
EDH17B2
HSD17
SDR9C2
hydroxysteroid (17-beta) dehydrogenase 2 (EC:1.1.1.62 1.1.1.239) HSD17B2 protein affects the metabolism of Estrone affects metabolic processing
protein 16054388
D004970 3294 HSD17B2
EDH17B2
HSD17
SDR9C2
hydroxysteroid (17-beta) dehydrogenase 2 (EC:1.1.1.62 1.1.1.239) HSD17B2 protein results in increased chemical synthesis of Estrone increases chemical synthesis
protein 16054388
D004970 3295 HSD17B4
DBP
MFE-2
MPF-2
PRLTS1
SDR8C1
hydroxysteroid (17-beta) dehydrogenase 4 (EC:4.2.1.107 4.2.1.119 1.1.1.n12) HSD17B4 protein affects the metabolism of Estrone affects metabolic processing
protein 16054388
D004970 3295 HSD17B4
DBP
MFE-2
MPF-2
PRLTS1
SDR8C1
hydroxysteroid (17-beta) dehydrogenase 4 (EC:4.2.1.107 4.2.1.119 1.1.1.n12) HSD17B4 protein results in increased chemical synthesis of Estrone increases chemical synthesis
protein 16054388
D004970 51478 HSD17B7
PRAP
SDR37C1
hydroxysteroid (17-beta) dehydrogenase 7 (EC:1.1.1.62 1.1.1.270) HSD17B7 protein affects the metabolism of Estrone affects metabolic processing
protein 16054388
D004970 51478 HSD17B7
PRAP
SDR37C1
hydroxysteroid (17-beta) dehydrogenase 7 (EC:1.1.1.62 1.1.1.270) HSD17B7 protein results in increased chemical synthesis of Estrone increases chemical synthesis
protein 16054388
D004970 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estrone results in increased phosphorylation of MAPK1 protein] decreases reaction
/ increases phosphorylation
protein 21767602
D004970 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Estrone results in increased phosphorylation of MAPK1 protein increases phosphorylation
protein 21767602
D004970 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) 2-(2-amino-3-methoxyphenyl)-4H-1-benzopyran-4-one inhibits the reaction [Estrone results in increased phosphorylation of MAPK3 protein] decreases reaction
/ increases phosphorylation
protein 21767602
D004970 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Estrone results in increased phosphorylation of MAPK3 protein increases phosphorylation
protein 21767602
D004970 8202 NCOA3
ACTR
AIB-1
AIB1
CAGH16
CTG26
KAT13B
RAC3
SRC-3
SRC3
TNRC14
TNRC16
TRAM-1
bHLHe42
pCIP
nuclear receptor coactivator 3 (EC:2.3.1.48) Estrone results in increased expression of NCOA3 mRNA increases expression
mRNA 21767602
D004970 8202 NCOA3
ACTR
AIB-1
AIB1
CAGH16
CTG26
KAT13B
RAC3
SRC-3
SRC3
TNRC14
TNRC16
TRAM-1
bHLHe42
pCIP
nuclear receptor coactivator 3 (EC:2.3.1.48) Estrone results in increased expression of NCOA3 protein increases expression
protein 21767602
D004970 5154 PDGFA
PDGF-A
PDGF1
platelet-derived growth factor alpha polypeptide Estrone results in decreased expression of PDGFA mRNA decreases expression
mRNA 10731640
D004970 5174 PDZK1
CAP70
CLAMP
NHERF-3
NHERF3
PDZD1
PDZ domain containing 1 Estrone results in increased expression of PDZK1 mRNA increases expression
mRNA 15159206
D004970 5241 PGR
NR3C3
PR
progesterone receptor Estrone results in decreased expression of PGR mRNA alternative form decreases expression
mRNA 15806153
D004970 5241 PGR
NR3C3
PR
progesterone receptor Estrone results in decreased expression of PGR protein alternative form decreases expression
protein 15806153
D004970 5241 PGR
NR3C3
PR
progesterone receptor fulvestrant inhibits the reaction [Estrone results in decreased expression of PGR protein alternative form] decreases expression
/ decreases reaction
protein 15806153
D004970 6286 S100P
MIG9
S100 calcium binding protein P Estrone results in increased expression of S100P mRNA increases expression
mRNA 15159206
D004970 8991 SELENBP1
LPSB
SBP56
SP56
hSBP
selenium binding protein 1 Estrone results in decreased expression of SELENBP1 mRNA decreases expression
mRNA 15159206
D004970 6558 SLC12A2
BSC
BSC2
NKCC1
solute carrier family 12 (sodium/potassium/chloride transporter), member 2 Estrone results in decreased expression of SLC12A2 mRNA decreases expression
mRNA 15159206
D004970 23657 SLC7A11
CCBR1
xCT
solute carrier family 7 (anionic amino acid transporter light chain, xc- system), member 11 Estrone results in increased expression of SLC7A11 mRNA increases expression
mRNA 15159206
D004970 412 STS
ARSC
ARSC1
ASC
ES
SSDD
XLI
steroid sulfatase (microsomal), isozyme S (EC:3.1.6.2) STS protein results in increased chemical synthesis of Estrone increases chemical synthesis
protein 16054388
D004970 6818 SULT1A3
HAST
HAST3
M-PST
ST1A3/ST1A4
ST1A5
STM
TL-PST
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) Estrone affects the sulfation of SULT1A3 protein affects sulfation
protein 11358677
D004970 6818 SULT1A3
HAST
HAST3
M-PST
ST1A3/ST1A4
ST1A5
STM
TL-PST
sulfotransferase family, cytosolic, 1A, phenol-preferring, member 3 (EC:2.8.2.1) [Estrone co-treated with SULT1A3 protein] results in decreased sulfation of Ethinyl Estradiol affects cotreatment
/ decreases sulfation
protein 15483196
D004970 6783 SULT1E1
EST
EST-1
ST1E1
STE
sulfotransferase family 1E, estrogen-preferring, member 1 (EC:2.8.2.4) Estrone affects the sulfation of SULT1E1 protein affects sulfation
protein 11358677
D004970 6783 SULT1E1
EST
EST-1
ST1E1
STE
sulfotransferase family 1E, estrogen-preferring, member 1 (EC:2.8.2.4) [Estrone co-treated with SULT1E1 protein] results in decreased sulfation of Ethinyl Estradiol affects cotreatment
/ decreases sulfation
protein 15483196
D004970 6783 SULT1E1
EST
EST-1
ST1E1
STE
sulfotransferase family 1E, estrogen-preferring, member 1 (EC:2.8.2.4) Estrone results in decreased activity of SULT1E1 protein decreases activity
protein 16914110
D004970 6783 SULT1E1
EST
EST-1
ST1E1
STE
sulfotransferase family 1E, estrogen-preferring, member 1 (EC:2.8.2.4) SULT1E1 protein results in increased sulfation of Estrone increases sulfation
protein 8185618
D004970 25830 SULT4A1
BR-STL-1
BRSTL1
DJ388M5.3
NST
SULTX3
hBR-STL-1
sulfotransferase family 4A, member 1 (EC:2.8.2.-) SULT4A1 protein results in increased metabolism of Estrone increases metabolic processing
protein 12039030
D004970 7031 TFF1
BCEI
D21S21
HP1.A
HPS2
pNR-2
pS2
trefoil factor 1 Estrone results in increased expression of TFF1 mRNA increases expression
mRNA 22562034
D004970 7031 TFF1
BCEI
D21S21
HP1.A
HPS2
pNR-2
pS2
trefoil factor 1 fulvestrant inhibits the reaction [Estrone results in increased expression of TFF1 mRNA] decreases reaction
/ increases expression
mRNA 22562034
D004970 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor TNF protein promotes the reaction [CYP19A1 protein affects the chemical synthesis of Estrone] affects chemical synthesis
/ increases reaction
protein 16030167
D004970 54658 UGT1A1
BILIQTL1
GNT1
HUG-BR1
UDPGT
UDPGT_1-1
UGT1
UGT1A
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) UGT1A1 protein results in increased glucuronidation of Estrone increases glucuronidation
protein 15117964
15472229
D004970 54658 UGT1A1
BILIQTL1
GNT1
HUG-BR1
UDPGT
UDPGT_1-1
UGT1
UGT1A
UDP glucuronosyltransferase 1 family, polypeptide A1 (EC:2.4.1.17) UGT1A1 protein results in increased glucuronidation of Estrone analog increases glucuronidation
protein 15472229
D004970 54575 UGT1A10
UDPGT
UGT-1J
UGT1-10
UGT1.10
UGT1J
UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) UGT1A10 protein results in increased glucuronidation of Estrone increases glucuronidation
protein 15117964
15472229
D004970 54575 UGT1A10
UDPGT
UGT-1J
UGT1-10
UGT1.10
UGT1J
UDP glucuronosyltransferase 1 family, polypeptide A10 (EC:2.4.1.17) UGT1A10 protein results in increased glucuronidation of Estrone analog increases glucuronidation
protein 15472229
D004970 54659 UGT1A3
UDPGT
UDPGT_1-3
UGT-1C
UGT1-03
UGT1.3
UGT1C
UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) UGT1A3 protein results in increased glucuronidation of Estrone increases glucuronidation
protein 15117964
15472229
D004970 54659 UGT1A3
UDPGT
UDPGT_1-3
UGT-1C
UGT1-03
UGT1.3
UGT1C
UDP glucuronosyltransferase 1 family, polypeptide A3 (EC:2.4.1.17) UGT1A3 protein results in increased glucuronidation of Estrone analog increases glucuronidation
protein 15472229
D004970 54577 UGT1A7
UDPGT
UDPGT_1-7
UGT-1G
UGT1-07
UGT1.7
UGT1G
UDP glucuronosyltransferase 1 family, polypeptide A7 (EC:2.4.1.17) UGT1A7 protein results in increased glucuronidation of Estrone increases glucuronidation
protein 15117964
D004970 54576 UGT1A8
UDPGT
UDPGT_1-8
UGT-1H
UGT1-08
UGT1.8
UGT1A8S
UGT1H
UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) UGT1A8 protein results in increased glucuronidation of Estrone increases glucuronidation
protein 15117964
15472229
D004970 54576 UGT1A8
UDPGT
UDPGT_1-8
UGT-1H
UGT1-08
UGT1.8
UGT1A8S
UGT1H
UDP glucuronosyltransferase 1 family, polypeptide A8 (EC:2.4.1.17) UGT1A8 protein results in increased glucuronidation of Estrone analog increases glucuronidation
protein 15472229
D004970 54600 UGT1A9
HLUGP4
LUGP4
UDPGT
UDPGT_1-9
UGT-1I
UGT1-09
UGT1-9
UGT1.9
UGT1AI
UGT1I
UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) UGT1A9 protein results in increased glucuronidation of Estrone increases glucuronidation
protein 15472229
D004970 54600 UGT1A9
HLUGP4
LUGP4
UDPGT
UDPGT_1-9
UGT-1I
UGT1-09
UGT1-9
UGT1.9
UGT1AI
UGT1I
UDP glucuronosyltransferase 1 family, polypeptide A9 (EC:2.4.1.17) UGT1A9 protein results in increased glucuronidation of Estrone analog increases glucuronidation
protein 15472229
D004970 7364 UGT2B7
UDPGT_2B9
UDPGT2B7
UDPGTH2
UGT2B9
UDP glucuronosyltransferase 2 family, polypeptide B7 (EC:2.4.1.17) UGT2B7 protein results in increased glucuronidation of Estrone increases glucuronidation
protein 15472229
D004970 7364 UGT2B7
UDPGT_2B9
UDPGT2B7
UDPGTH2
UGT2B9
UDP glucuronosyltransferase 2 family, polypeptide B7 (EC:2.4.1.17) UGT2B7 protein results in increased glucuronidation of Estrone analog increases glucuronidation
protein 15472229
D004970 7453 WARS
GAMMA-2
IFI53
IFP53
tryptophanyl-tRNA synthetase (EC:6.1.1.2) Estrone results in increased expression of WARS mRNA increases expression
mRNA 15159206
D004970 331 XIAP
API3
BIRC4
IAP-3
ILP1
MIHA
XLP2
hIAP-3
hIAP3
X-linked inhibitor of apoptosis Estrone results in increased expression of XIAP mRNA increases expression
mRNA 21767602
D004970 331 XIAP
API3
BIRC4
IAP-3
ILP1
MIHA
XLP2
hIAP-3
hIAP3
X-linked inhibitor of apoptosis Estrone results in increased expression of XIAP protein increases expression
protein 21767602

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (76)

OMIM preferred title UniProt
#300438 17-beta-hydroxysteroid dehydrogenase x deficiency Q99714
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#103780 Alcohol dependence P08172
P14416
P31645
#612069 Amyotrophic lateral sclerosis 10, with or without frontotemporal dementia; als10 Q13148
#614373 Amyotrophic lateral sclerosis 16, juvenile; als16 Q99720
#300068 Androgen insensitivity syndrome; ais P10275
#312300 Androgen insensitivity, partial; pais P10275
#601816 Bilirubin, serum level of, quantitative trait locus 1; biliqtl1 P22309
#614490 Blood group, junior system; jr Q9UNQ0
#210900 Bloom syndrome; blm P54132
#602025 Body mass index quantitative trait locus 9; bmiq9 P41968
#612560 Bone mineral density quantitative trait locus 12; bmnd12 O75795
#300615 Brunner syndrome P21397
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#118300 Charcot-marie-tooth disease and deafness Q01453
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#118220 Charcot-marie-tooth disease, demyelinating, type 1a; cmt1a Q01453
#611489 Corticosteroid-binding globulin deficiency P08185
#218800 Crigler-najjar syndrome, type i P22309
P22310
#606785 Crigler-najjar syndrome, type ii P22309
P22310
#162800 Cyclic neutropenia P08246
#612522 Diabetes mellitus, insulin-dependent, 22; iddm22 P51681
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#615363 Estrogen resistance; estrr P03372
#600274 Frontotemporal dementia; ftd P10636
#613659 Gastric cancer P04626
#137215 Gastric cancer, hereditary diffuse; hdgc P04626
#231095 Ghosal hematodiaphyseal dysplasia; ghdd P24557
#143500 Gilbert syndrome P22309
P22310
#137800 Glioma susceptibility 1; glm1 P04626
#139393 Guillain-barre syndrome, familial; gbs Q01453
#610140 Heart-hand syndrome, slovenian type P02545
#609423 Human immunodeficiency virus type 1, susceptibility to P41597
P51681
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#237450 Hyperbilirubinemia, rotor type; hblrr Q9Y6L6
#237900 Hyperbilirubinemia, transient familial neonatal; hblrtfn P22309
#145900 Hypertrophic neuropathy of dejerine-sottas Q01453
#308100 Ichthyosis, x-linked; xli P08842
#612244 Inflammatory bowel disease 13; ibd13 P08183
#603932 Intervertebral disc disease; idd P14780
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#613688 Long qt syndrome 2; lqt2 Q12809
#211980 Lung cancer P00533
P04626
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#300705 Mental retardation, x-linked 17; mrx17 Q99714
%300852 Mental retardation, x-linked 88; mrx88 P50052
#300220 Mental retardation, x-linked, syndromic 10; mrxs10 Q99714
#613073 Metaphyseal anadysplasia 2; mandp2 P14780
#126200 Multiple sclerosis, susceptibility to; ms P08575
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#159900 Myoclonic dystonia P14416
#162500 Neuropathy, hereditary, with liability to pressure palsies; hnpp Q01453
#202700 Neutropenia, severe congenital, 1, autosomal dominant; scn1 P08246
#601665 Obesity P32245
#164230 Obsessive-compulsive disorder; ocd P31645
#604715 Orthostatic intolerance P23975
#259730 Osteopetrosis, autosomal recessive 3; optb3 P00918
#167000 Ovarian cancer P04626
#260540 Parkinson-dementia syndrome P10636
#613135 Parkinsonism-dystonia, infantile; pkdys Q01959
#172700 Pick disease of brain P10636
#607276 Resting heart rate, variation in P08588
#275210 Restrictive dermopathy, lethal P02545
#608971 Severe combined immunodeficiency, autosomal recessive, t cell-negative, b cell-positive, nk cell-positive P08575
#609620 Short qt syndrome 1; sqt1 Q12809
#313200 Spinal and bulbar muscular atrophy, x-linked 1; smax1 P10275
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#190300 Tremor, hereditary essential, 1; etm1 P35462
#138900 Uric acid concentration, serum, quantitative trait locus 1; uaqtl1 Q9UNQ0
#610379 West nile virus, susceptibility to P51681
#112100 Yt blood group antigen P22303

KEGG DISEASE (56)

KEGG disease name UniProt
H00016 Oral cancer P00533 (related)
P00533 (marker)
H00017 Esophageal cancer P00533 (related)
P35354 (related)
H00018 Gastric cancer P00533 (related)
P04626 (related)
H00022 Bladder cancer P00533 (related)
P04626 (related)
H00028 Choriocarcinoma P00533 (related)
P03956 (related)
P04626 (related)
H00030 Cervical cancer P00533 (related)
P04626 (related)
H00042 Glioma P00533 (related)
P00533 (marker)
H00055 Laryngeal cancer P00533 (related)
P00533 (marker)
H00241 Combined proximal and distal renal tubular acidosis (RTA type 3) P00918 (related)
H00436 Osteopetrosis P00918 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
Q01453 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00026 Endometrial Cancer P03372 (marker)
P04626 (related)
Q92731 (marker)
H00599 46,XX disorders of sex development (Disorders related to androgen excess) P04150 (related)
H00019 Pancreatic cancer P04626 (related)
H00027 Ovarian cancer P04626 (related)
H00031 Breast cancer P04626 (related)
P04626 (marker)
H00046 Cholangiocarcinoma P04626 (related)
P35354 (related)
H00093 Combined immunodeficiencies (CIDs) P06239 (related)
H00079 Asthma P07550 (related)
H01163 Corticosteroid-binding globulin (CBG) deficiency P08185 (related)
H00100 Neutropenic disorders P08246 (related)
H00091 T-B+Severe combined immunodeficiencies (SCIDs) P08575 (related)
H00036 Osteosarcoma P08684 (marker)
H00134 X-linked ichthyosis (XLI) P08842 (related)
H00024 Prostate cancer P10275 (related)
H00062 Spinal and bulbar muscular atrophy (SBMA) P10275 (related)
H00608 46,XY disorders of sex development (Disorders in androgen synthesis or action) P10275 (related)
H00609 46,XY disorders of sex development (Other) P10275 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
Q13148 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H00025 Penile cancer P14780 (related)
P35354 (related)
H00479 Metaphyseal dysplasias P14780 (related)
H00548 Brunner syndrome P21397 (related)
H00208 Hyperbilirubinemia P22309 (related)
H01031 Orthostatic intolerance (OI) P23975 (related)
H00490 Diaphyseal dysplasia with anemia (Ghosal) P24557 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00480 Non-syndromic X-linked mental retardation P50052 (related)
Q99714 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H01296 Hereditary neuropathy with liability to pressure palsies (HNPP) Q01453 (related)
H00720 Long QT syndrome Q12809 (related)
H00725 Short QT syndrome Q12809 (related)
H00658 Syndromic X-linked mental retardation Q99714 (related)
H00925 2-Methyl-3-hydroxybutyryl-CoA dehydrogenase (MHBD) deficiency Q99714 (related)

Diseases related to CTD interactions

14 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D000230 D004970 Adenocarcinoma marker/mechanism
858144
5556578
D000782 D004970 Aneuploidy marker/mechanism
10728588
D002471 D004970 Cell Transformation, Neoplastic marker/mechanism
10728588
D019457 D004970 Chromosome Breakage marker/mechanism
10728588
D006177 D004970 Gynecomastia marker/mechanism
15483104
D006943 D004970 Hyperglycemia therapeutic
3519326
D006946 D004970 Hyperinsulinism therapeutic
3519326
D007006 D004970 Hypogonadism marker/mechanism
15483104
D007680 D004970 Kidney Neoplasms marker/mechanism
15610895
D010182 D004970 Pancreatic Diseases therapeutic
3519326
D010911 D004970 Pituitary Neoplasms marker/mechanism
6540183
D015175 D004970 Prolactinoma marker/mechanism
1657658
D011471 D004970 Prostatic Neoplasms marker/mechanism
858144
D014625 D004970 Vaginal Neoplasms marker/mechanism
5556578