KEGG BRITE br08003 External link 512


Categories (1)

br08003 Category # of metabolite
Amines 5

metabolites link (5)

br08003 Category KEGG ID KNApSAcK ID
Amines C00179 C00001400
Amines C00436 C00001404
Amines C08303 C00001410
Amines C08307 C00001415
Amines C08308 C00001416

KCF-S cluster (4)

KCF-S ID # of metabolite
No. 4654 2
No. 6012 1
No. 7764 1
No. 7327 1

Metabolite list (5)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
KCF-S
cluster
figure
C00001416 External link 512 N-Carbamoylputrescine
C024563
No. 4654
C00001415 External link 512 Agmatine
CHEMBL58343
D000376
11 / 2 / 3 0 / 9 No. 4654
C00001410 External link 512 Galegine
CHEMBL111469
C074315
No. 6012
C00001400 External link 512 Hordatine B
No. 7327
C00001404 External link 512 Hordatine A
CHEMBL567589
CHEMBL566278
CHEMBL585895
CHEMBL568182
No. 7764

Human Protein / Gene in interactions

11 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00001400 1 / 0
O15244 Solute carrier family 22 member 2 Drug uniporter C00001400 0 / 0
O15245 Solute carrier family 22 member 1 Drug uniporter C00001400 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00001400 0 / 1
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00001400 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00001400 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00001400 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00001400 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00001400 0 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00001400 0 / 0
O75751 Solute carrier family 22 member 3 Unclassified protein C00001400 0 / 0

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (2)

OMIM preferred title UniProt
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635

KEGG DISEASE (3)

KEGG name UniProt
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)

Diseases related to CTD interactions

9 disease in interactions with metabolites

MESH or OMIM name KNApSAcK
metabolite
D001919 Bradycardia C00001400
D006930 Hyperalgesia C00001400
D006973 Hypertension C00001400
D007022 Hypotension C00001400
D009021 Morphine Dependence C00001400
D009293 Opioid-Related Disorders C00001400
D010146 Pain C00001400
D013375 Substance Withdrawal Syndrome C00001400
D013610 Tachycardia C00001400