Plant Species

Cumulative plant class count

class name count
rosids 4

Cumulative family count

class name count
Rutaceae 4

KEGG BRITE br08003 External link 512

Categories (1)

br08003 Category # of metabolite
Imidazole alkaloids 2

metabolites link (2)

br08003 Category KEGG ID KNApSAcK ID
Imidazole alkaloids C07474 C00002355
Imidazole alkaloids C10610 C00002356

KCF-S cluster (2)

KCF-S ID # of metabolite
No. 7873 1
No. 8181 1

Metabolite list (2)

KNApSAcK ID name ChEMBL link CTD link # of proteins in
ChEMBL interaction
/ related OMIM
/ related KEGG DISEASE
# of genes in
CTD interaction
/ related diseases
C00002355 External link 512 Pilocarpine
28 / 30 / 56 9 / 74 No. 7873
C00002356 External link 512 Pilosine
No. 8181

Human Protein / Gene in interactions

28 ChEMBL Protein in interactions

accession description class description KNApSAcK metabolite in interactions # of diseases
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 C00002355 1 / 0
P04637 Cellular tumor antigen p53 Transcription Factor C00002355 7 / 37
Q99700 Ataxin-2 Unclassified protein C00002355 1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein C00002355 2 / 0
Q13526 Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 Enzyme C00002355 0 / 0
O15245 Solute carrier family 22 member 1 Drug uniporter C00002355 0 / 0
O75604 Ubiquitin carboxyl-terminal hydrolase 2 Enzyme C00002355 0 / 0
P02545 Prelamin-A/C Unclassified protein C00002355 11 / 10
P08912 Muscarinic acetylcholine receptor M5 Acetylcholine receptor C00002355 0 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 C00002355 0 / 1
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 C00002355 0 / 0
Q92830 Histone acetyltransferase KAT2A Enzyme C00002355 0 / 0
P25101 Endothelin-1 receptor Endothelin receptor C00002355 0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein C00002355 0 / 0
P08172 Muscarinic acetylcholine receptor M2 Acetylcholine receptor C00002355 2 / 0
P11229 Muscarinic acetylcholine receptor M1 Acetylcholine receptor C00002355 0 / 0
P18054 Arachidonate 12-lipoxygenase, 12S-type Enzyme C00002355 2 / 0
P28482 Mitogen-activated protein kinase 1 Erk C00002355 0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 C00002355 0 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor C00002355 0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme C00002355 0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 C00002355 1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 C00002355 0 / 1
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme C00002355 0 / 0
O00255 Menin Unclassified protein C00002355 2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme C00002355 1 / 2
P20309 Muscarinic acetylcholine receptor M3 Acetylcholine receptor C00002355 1 / 0
P08173 Muscarinic acetylcholine receptor M4 Acetylcholine receptor C00002355 0 / 0

9 Gene in CTD interactions

gene gene name gene description KNApSAcK metabolite in interactions
836 CASP3, CPP32, CPP32B, SCA-1 caspase 3, apoptosis-related cysteine peptidase (EC: C00002355
1128 CHRM1, HM1, M1, M1R cholinergic receptor, muscarinic 1 C00002355
1129 CHRM2, HM2 cholinergic receptor, muscarinic 2 C00002355
1131 CHRM3, EGBRS, HM3 cholinergic receptor, muscarinic 3 C00002355
1132 CHRM4, HM4, M4R cholinergic receptor, muscarinic 4 C00002355
1548 CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB cytochrome P450, family 2, subfamily A, polypeptide 6 (EC: C00002355
3553 IL1B, IL-1, IL1-BETA, IL1F2 interleukin 1, beta C00002355
5599 MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c mitogen-activated protein kinase 8 (EC: C00002355
5747 PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK protein tyrosine kinase 2 (EC: C00002355

Related Diseases

Diseases related to proteins in ChEMBL interactions

OMIM (30)

OMIM preferred title UniProt
#100100 Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism P20309
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#103780 Alcohol dependence P08172
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#115200 Cardiomyopathy, dilated, 1a; cmd1a P02545
#212112 Cardiomyopathy, dilated, with hypergonadotropic hypogonadism P02545
#605588 Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 P02545
#114500 Colorectal cancer; crc P18054
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#181350 Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 P02545
#133239 Esophageal cancer P04637
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#610140 Heart-hand syndrome, slovenian type P02545
#176670 Hutchinson-gilford progeria syndrome; hgps P02545
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#151660 Lipodystrophy, familial partial, type 2; fpld2 P02545
#211980 Lung cancer P04637
#608516 Major depressive disorder; mdd P08172
#248370 Mandibuloacral dysplasia with type a lipodystrophy; mada P02545
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#613205 Muscular dystrophy, congenital, lmna-related P02545
#159001 Muscular dystrophy, limb-girdle, type 1b; lgmd1b P02545
#260500 Papilloma of choroid plexus; cpp P04637
#275210 Restrictive dermopathy, lethal P02545
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#275355 Squamous cell carcinoma, head and neck; hnscc P04637


KEGG name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00264 Charcot-Marie-Tooth disease (CMT) P02545 (related)
H00294 Dilated cardiomyopathy (DCM) P02545 (related)
H00420 Familial partial lipodystrophy (FPL) P02545 (related)
H00563 Emery-Dreifuss muscular dystrophy P02545 (related)
H00590 Congenital muscular dystrophies (CMD/MDC) P02545 (related)
H00593 Limb-girdle muscular dystrophy (LGMD) P02545 (related)
H00601 Hutchinson-Gilford progeria syndrome P02545 (related)
H00663 Restrictive dermopathy P02545 (related)
H00665 Mandibuloacral dysplasia P02545 (related)
H01216 Left ventricular noncompaction (LVNC) P02545 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)

Diseases related to CTD interactions

74 disease in interactions with metabolites

D000138 Acidosis C00002355
D001145 Arrhythmias, Cardiac C00002355
D054537 Atrioventricular Block C00002355
D001308 Auditory Perceptual Disorders C00002355
D001480 Basal Ganglia Diseases C00002355
D001764 Blepharospasm C00002355
D001919 Bradycardia C00002355
D001925 Brain Damage, Chronic C00002355
D001929 Brain Edema C00002355
D001930 Brain Injuries C00002355
D002545 Brain Ischemia C00002355
D006332 Cardiomegaly C00002355
D002375 Catalepsy C00002355
D002544 Cerebral Infarction C00002355
D019970 Cocaine-Related Disorders C00002355
D003072 Cognition Disorders C00002355
D003221 Confusion C00002355
D003229 Conjunctival Diseases C00002355
D003693 Delirium C00002355
D003704 Dementia C00002355
D003711 Demyelinating Diseases C00002355
D004195 Disease Models, Animal C00002355
D004244 Dizziness C00002355
D004828 Epilepsies, Partial C00002355
D004827 Epilepsy C00002355
D004832 Epilepsy, Absence C00002355
D004833 Epilepsy, Temporal Lobe C00002355
D004830 Epilepsy, Tonic-Clonic C00002355
D017889 Exfoliation Syndrome C00002355
D005221 Fatigue C00002355
D005334 Fever C00002355
D005901 Glaucoma C00002355
D015812 Glaucoma, Angle-Closure C00002355
D005902 Glaucoma, Open-Angle C00002355
D005911 Gliosis C00002355
D006212 Hallucinations C00002355
D006261 Headache C00002355
D006940 Hyperemia C00002355
D006948 Hyperkinesis C00002355
D006973 Hypertension C00002355
D007022 Hypotension C00002355
D007035 Hypothermia C00002355
D007249 Inflammation C00002355
D007859 Learning Disorders C00002355
D053609 Lethargy C00002355
D008569 Memory Disorders C00002355
D001523 Mental Disorders C00002355
D015877 Miosis C00002355
D028361 Mitochondrial Diseases C00002355
D009069 Movement Disorders C00002355
D015878 Mydriasis C00002355
D009207 Myoclonus C00002355
D009325 Nausea C00002355
D009336 Necrosis C00002355
D009389 Neovascularization, Pathologic C00002355
D009410 Nerve Degeneration C00002355
D009421 Nervous System Malformations C00002355
D019954 Neurobehavioral Manifestations C00002355
D019636 Neurodegenerative Diseases C00002355
D020258 Neurotoxicity Syndromes C00002355
D009798 Ocular Hypertension C00002355
D015814 Ocular Hypotension C00002355
D010146 Pain C00002355
D010554 Personality Disorders C00002355
D011605 Psychoses, Substance-Induced C00002355
D012598 Sclerosis C00002355
D012640 Seizures C00002355
D012798 Sialorrhea C00002355
D012859 Sjogren's Syndrome C00002355
D013226 Status Epilepticus C00002355
D014202 Tremor C00002355
D014549 Urinary Incontinence C00002355
D014786 Vision Disorders C00002355
D014987 Xerostomia C00002355