phytochemical cluster No. 8 (2 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• KCF-S cluster (2)
• Metabolite list (2)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	4

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Cumulative family count

class name	count
Rutaceae	4

KEGG BRITE br08003

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Categories (1)

br08003 Category	# of metabolite
Imidazole alkaloids	2

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metabolites link (2)

br08003 Category	KEGG ID	KNApSAcK ID
Imidazole alkaloids	C07474	C00002355
Imidazole alkaloids	C10610	C00002356

KCF-S cluster (2)

KCF-S ID	# of metabolite
No. 7873	1
No. 8181	1

Metabolite list (2)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	KCF-S cluster	figure
C00002355	Pilocarpine	CHEMBL550 CHEMBL91776 CHEMBL611494 CHEMBL1622903	D010862	28 / 30 / 56	9 / 74	No. 7873
C00002356	Pilosine	CHEMBL524663 CHEMBL1974385				No. 8181

Human Protein / Gene in interactions

28 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00002355	1 / 0
P04637	Cellular tumor antigen p53	Transcription Factor	C00002355	7 / 37
Q99700	Ataxin-2	Unclassified protein	C00002355	1 / 1
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00002355	2 / 0
Q13526	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1	Enzyme	C00002355	0 / 0
O15245	Solute carrier family 22 member 1	Drug uniporter	C00002355	0 / 0
O75604	Ubiquitin carboxyl-terminal hydrolase 2	Enzyme	C00002355	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00002355	11 / 10
P08912	Muscarinic acetylcholine receptor M5	Acetylcholine receptor	C00002355	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00002355	0 / 1
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00002355	0 / 0
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00002355	0 / 0
P25101	Endothelin-1 receptor	Endothelin receptor	C00002355	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00002355	0 / 0
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00002355	2 / 0
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00002355	0 / 0
P18054	Arachidonate 12-lipoxygenase, 12S-type	Enzyme	C00002355	2 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00002355	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00002355	0 / 0
P19838	Nuclear factor NF-kappa-B p105 subunit	Transcription Factor	C00002355	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00002355	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00002355	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00002355	0 / 1
Q96KQ7	Histone-lysine N-methyltransferase EHMT2	Enzyme	C00002355	0 / 0
O00255	Menin	Unclassified protein	C00002355	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00002355	1 / 2
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00002355	1 / 0
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00002355	0 / 0

9 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00002355
1128	CHRM1, HM1, M1, M1R	cholinergic receptor, muscarinic 1	C00002355
1129	CHRM2, HM2	cholinergic receptor, muscarinic 2	C00002355
1131	CHRM3, EGBRS, HM3	cholinergic receptor, muscarinic 3	C00002355
1132	CHRM4, HM4, M4R	cholinergic receptor, muscarinic 4	C00002355
1548	CYP2A6, CPA6, CYP2A, CYP2A3, CYPIIA6, P450C2A, P450PB	cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1)	C00002355
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00002355
5599	MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c	mitogen-activated protein kinase 8 (EC:2.7.11.24)	C00002355
5747	PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK	protein tyrosine kinase 2 (EC:2.7.10.2)	C00002355

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions