KNApSAcK Metabolite C00002355
Metabolite
KNApSAcK Entry
| id | C00002355 |
|---|---|
| Name | Pilocarpine |
| CAS RN | 92-13-7 |
| Standard InChI | InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3/t8-,10-/m0/s1 |
| Standard InChI (Main Layer) | InChI=1S/C11H16N2O2/c1-3-10-8(6-15-11(10)14)4-9-5-12-7-13(9)2/h5,7-8,10H,3-4,6H2,1-2H3 |
Cluster
| Phytochemical cluster | No. 8 |
|---|---|
| KCF-S cluster | No. 7873 |
Link
ChEMBL
| By standard InChI | CHEMBL550 |
|---|---|
| By standard InChI Main Layer | CHEMBL550 CHEMBL91776 CHEMBL611494 CHEMBL1622903 |
KEGG
| By LinkDB | C07474 |
|---|
CTD
| By CAS RN | D010862 |
|---|
Species
Summary
List (3)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Pilocarpus jaborandi | 1331806 | Rutaceae | rosids | Viridiplantae |
| Pilocarpus microphyllus | 77016 | Rutaceae | rosids | Viridiplantae |
| Pilocarpus pennatifolius Lem. | 77017 | Rutaceae | rosids | Viridiplantae |
Human Protein / Gene in interaction
28 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P10635 | Cytochrome P450 2D6 | Cytochrome P450 2D6 | CHEMBL611494 |
CHEMBL1741321
(5)
|
1 / 0 |
| P04637 | Cellular tumor antigen p53 | Transcription Factor | CHEMBL611494 |
CHEMBL1613992
(1)
|
7 / 44 |
| Q99700 | Ataxin-2 | Unclassified protein | CHEMBL611494 |
CHEMBL2114784
(2)
|
1 / 1 |
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | CHEMBL611494 |
CHEMBL1794499
(3)
|
2 / 0 |
| Q13526 | Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1 | Enzyme | CHEMBL611494 |
CHEMBL1738600
(1)
|
0 / 0 |
| O15245 | Solute carrier family 22 member 1 | Drug uniporter | CHEMBL611494 |
CHEMBL993349
(1)
|
0 / 0 |
| O75604 | Ubiquitin carboxyl-terminal hydrolase 2 | Enzyme | CHEMBL611494 |
CHEMBL1614331
(1)
|
0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | CHEMBL611494 |
CHEMBL1614544
(1)
|
11 / 10 |
| P08912 | Muscarinic acetylcholine receptor M5 | Acetylcholine receptor | CHEMBL611494 |
CHEMBL749057
(1)
CHEMBL923037
(1)
|
0 / 0 |
| P11712 | Cytochrome P450 2C9 | Cytochrome P450 2C9 | CHEMBL91776 CHEMBL611494 |
CHEMBL1614027
(4)
CHEMBL1741325
(5)
|
0 / 1 |
| P11509 | Cytochrome P450 2A6 | Cytochrome P450 2A6 | CHEMBL611494 |
CHEMBL1743275
(1)
|
0 / 0 |
| Q92830 | Histone acetyltransferase KAT2A | Enzyme | CHEMBL611494 |
CHEMBL1738606
(1)
|
0 / 0 |
| P25101 | Endothelin-1 receptor | Endothelin receptor | CHEMBL611494 |
CHEMBL676596
(1)
|
0 / 0 |
| P83916 | Chromobox protein homolog 1 | Unclassified protein | CHEMBL611494 |
CHEMBL1738610
(1)
|
0 / 0 |
| P08172 | Muscarinic acetylcholine receptor M2 | Acetylcholine receptor | CHEMBL611494 |
CHEMBL749057
(1)
CHEMBL745634
(1)
CHEMBL745647 (1) CHEMBL847458 (1) CHEMBL923036 (1) |
2 / 0 |
| P11229 | Muscarinic acetylcholine receptor M1 | Acetylcholine receptor | CHEMBL611494 |
CHEMBL749057
(1)
CHEMBL748279
(1)
CHEMBL744060 (1) CHEMBL744061 (1) CHEMBL923035 (1) |
0 / 0 |
| P18054 | Arachidonate 12-lipoxygenase, 12S-type | Enzyme | CHEMBL611494 |
CHEMBL1614252
(1)
|
2 / 0 |
| P28482 | Mitogen-activated protein kinase 1 | Erk | CHEMBL611494 |
CHEMBL1613808
(1)
|
0 / 0 |
| P05177 | Cytochrome P450 1A2 | Cytochrome P450 1A2 | CHEMBL611494 |
CHEMBL1741322
(5)
|
0 / 0 |
| P19838 | Nuclear factor NF-kappa-B p105 subunit | Transcription Factor | CHEMBL611494 |
CHEMBL1614274
(2)
CHEMBL1613823
(2)
|
0 / 0 |
| P16050 | Arachidonate 15-lipoxygenase | Enzyme | CHEMBL611494 |
CHEMBL1614240
(1)
|
0 / 0 |
| P33261 | Cytochrome P450 2C19 | Cytochrome P450 2C19 | CHEMBL611494 |
CHEMBL1613777
(2)
CHEMBL1741323
(5)
|
1 / 1 |
| P08684 | Cytochrome P450 3A4 | Cytochrome P450 3A4 | CHEMBL611494 |
CHEMBL1614108
(5)
CHEMBL1613886
(5)
CHEMBL1741324 (5) |
0 / 1 |
| Q96KQ7 | Histone-lysine N-methyltransferase EHMT2 | Enzyme | CHEMBL611494 |
CHEMBL1738442
(2)
|
0 / 0 |
| O00255 | Menin | Unclassified protein | CHEMBL611494 |
CHEMBL1614531
(1)
|
2 / 5 |
| Q03164 | Histone-lysine N-methyltransferase 2A | Enzyme | CHEMBL611494 |
CHEMBL1614531
(1)
|
1 / 3 |
| P20309 | Muscarinic acetylcholine receptor M3 | Acetylcholine receptor | CHEMBL611494 |
CHEMBL749057
(1)
|
1 / 0 |
| P08173 | Muscarinic acetylcholine receptor M4 | Acetylcholine receptor | CHEMBL611494 |
CHEMBL749057
(1)
|
0 / 0 |
CTD interaction (28)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D010862 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein] |
decreases reaction
/ increases activity |
protein |
19927300
|
| D010862 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein] |
decreases reaction
/ increases activity |
protein |
19927300
|
| D010862 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein] |
decreases reaction
/ increases activity |
protein |
19927300
|
| D010862 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Pilocarpine results in increased activity of CASP3 protein |
increases activity
|
protein |
19927300
|
| D010862 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Verapamil inhibits the reaction [Pilocarpine results in increased activity of CASP3 protein] |
decreases reaction
/ increases activity |
protein |
19927300
|
| D010862 | 1128 |
CHRM1
HM1 M1 M1R |
cholinergic receptor, muscarinic 1 | brucine promotes the reaction [Pilocarpine binds to CHRM1 protein] |
affects binding
/ increases reaction |
protein |
9224827
|
| D010862 | 1128 |
CHRM1
HM1 M1 M1R |
cholinergic receptor, muscarinic 1 | CHRM1 protein binds to Pilocarpine |
affects binding
|
protein |
9224827
|
| D010862 | 1128 |
CHRM1
HM1 M1 M1R |
cholinergic receptor, muscarinic 1 | Pilocarpine results in increased activity of CHRM1 protein |
increases activity
|
protein |
11527950
|
| D010862 | 1128 |
CHRM1
HM1 M1 M1R |
cholinergic receptor, muscarinic 1 | [Pilocarpine results in increased activity of CHRM1 protein] which results in increased abundance of Calcium |
increases abundance
/ increases activity |
protein |
11527950
|
| D010862 | 1129 |
CHRM2
HM2 |
cholinergic receptor, muscarinic 2 | CHRM2 protein binds to Pilocarpine |
affects binding
|
protein |
9224827
|
| D010862 | 1129 |
CHRM2
HM2 |
cholinergic receptor, muscarinic 2 | eburnamonine promotes the reaction [Pilocarpine binds to CHRM2 protein] |
affects binding
/ increases reaction |
protein |
9224827
|
| D010862 | 1131 |
CHRM3
EGBRS HM3 |
cholinergic receptor, muscarinic 3 | brucine promotes the reaction [Pilocarpine binds to CHRM3 protein] |
affects binding
/ increases reaction |
protein |
9224827
|
| D010862 | 1131 |
CHRM3
EGBRS HM3 |
cholinergic receptor, muscarinic 3 | CHRM3 protein binds to Pilocarpine |
affects binding
|
protein |
9224827
|
| D010862 | 1132 |
CHRM4
HM4 M4R |
cholinergic receptor, muscarinic 4 | brucine promotes the reaction [Pilocarpine binds to CHRM4 protein] |
affects binding
/ increases reaction |
protein |
9224827
|
| D010862 | 1132 |
CHRM4
HM4 M4R |
cholinergic receptor, muscarinic 4 | CHRM4 protein binds to Pilocarpine |
affects binding
|
protein |
9224827
|
| D010862 | 1132 |
CHRM4
HM4 M4R |
cholinergic receptor, muscarinic 4 | eburnamonine promotes the reaction [Pilocarpine binds to CHRM4 protein] |
affects binding
/ increases reaction |
protein |
9224827
|
| D010862 | 1548 |
CYP2A6
CPA6 CYP2A CYP2A3 CYPIIA6 P450C2A P450PB |
cytochrome P450, family 2, subfamily A, polypeptide 6 (EC:1.14.14.1) | Pilocarpine results in decreased activity of CYP2A6 protein |
decreases activity
|
protein |
12464242
|
| D010862 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | phenylmethylpyrazolone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of IL1B mRNA] |
affects cotreatment
/ decreases reaction / increases expression |
mRNA |
19951488
|
| D010862 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | phenylmethylpyrazolone inhibits the reaction [[Pilocarpine co-treated with Lithium] results in increased expression of IL1B protein] |
affects cotreatment
/ decreases reaction / increases expression |
protein |
19951488
|
| D010862 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | [Pilocarpine co-treated with Lithium] results in increased expression of IL1B mRNA |
affects cotreatment
/ increases expression |
mRNA |
19951488
|
| D010862 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | [Pilocarpine co-treated with Lithium] results in increased expression of IL1B protein |
affects cotreatment
/ increases expression |
protein |
19951488
|
| D010862 | 5599 |
MAPK8
JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c |
mitogen-activated protein kinase 8 (EC:2.7.11.24) | 1,2-bis(2-aminophenoxy)ethane N,N,N',N'-tetraacetic acid acetoxymethyl ester inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein] |
decreases reaction
/ increases activity |
protein |
19927300
|
| D010862 | 5599 |
MAPK8
JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c |
mitogen-activated protein kinase 8 (EC:2.7.11.24) | 1,2-bis(2-aminophenoxy)ethane-N,N,N',N'-tetraacetic acid inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein] |
decreases reaction
/ increases activity |
protein |
19927300
|
| D010862 | 5599 |
MAPK8
JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c |
mitogen-activated protein kinase 8 (EC:2.7.11.24) | 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein] |
decreases reaction
/ increases activity |
protein |
19927300
|
| D010862 | 5599 |
MAPK8
JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c |
mitogen-activated protein kinase 8 (EC:2.7.11.24) | Pilocarpine results in increased activity of MAPK8 protein |
increases activity
|
protein |
19927300
|
| D010862 | 5599 |
MAPK8
JNK JNK-46 JNK1 JNK1A2 JNK21B1/2 PRKM8 SAPK1 SAPK1c |
mitogen-activated protein kinase 8 (EC:2.7.11.24) | W 7 inhibits the reaction [Pilocarpine results in increased activity of MAPK8 protein] |
decreases reaction
/ increases activity |
protein |
19927300
|
| D010862 | 5747 |
PTK2
FADK FAK FAK1 FRNK PPP1R71 p125FAK pp125FAK |
protein tyrosine kinase 2 (EC:2.7.10.2) | [Pilocarpine co-treated with wortmannin] results in increased phosphorylation of PTK2 protein |
affects cotreatment
/ increases phosphorylation |
protein |
10537051
|
| D010862 | 5747 |
PTK2
FADK FAK FAK1 FRNK PPP1R71 p125FAK pp125FAK |
protein tyrosine kinase 2 (EC:2.7.10.2) | Pilocarpine results in increased phosphorylation of PTK2 protein |
increases phosphorylation
|
protein |
10537051
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (30)
| OMIM | preferred title | UniProt |
|---|---|---|
| #100100 | Abdominal muscles, absence of, with urinary tract abnormality and cryptorchidism |
P20309
|
| #202300 | Adrenocortical carcinoma, hereditary; adcc |
P04637
|
| #103780 | Alcohol dependence |
P08172
|
| #614740 | Basal cell carcinoma, susceptibility to, 7; bcc7 |
P04637
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #114500 | Colorectal cancer; crc |
P18054
|
| #609535 | Drug metabolism, poor, cyp2c19-related |
P33261
|
| #608902 | Drug metabolism, poor, cyp2d6-related |
P10635
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #133239 | Esophageal cancer |
P04637
P18054 |
| #605130 | Hairy elbows, short stature, facial dysmorphism, and developmental delay |
Q03164
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #145000 | Hyperparathyroidism 1; hrpt1 |
O00255
|
| #151623 | Li-fraumeni syndrome 1; lfs1 |
P04637
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #211980 | Lung cancer |
P04637
|
| #608516 | Major depressive disorder; mdd |
P08172
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #131100 | Multiple endocrine neoplasia, type i; men1 |
O00255
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #260500 | Papilloma of choroid plexus; cpp |
P04637
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| #183090 | Spinocerebellar ataxia 2; sca2 |
Q99700
|
| #275355 | Squamous cell carcinoma, head and neck; hnscc |
P04637
|
KEGG DISEASE (56)
| KEGG | disease name | UniProt |
|---|---|---|
| H00033 | Adrenal carcinoma |
O00255
(related)
P04637 (related) |
| H00034 | Carcinoid |
O00255
(related)
|
| H00045 | Malignant islet cell carcinoma |
O00255
(related)
|
| H00246 | Primary hyperparathyroidism |
O00255
(related)
|
| H01102 | Pituitary adenomas |
O00255
(related)
|
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
|
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00004 | Chronic myeloid leukemia (CML) |
P04637
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04637
(related)
|
| H00006 | Hairy-cell leukemia |
P04637
(related)
|
| H00008 | Burkitt lymphoma |
P04637
(related)
|
| H00009 | Adult T-cell leukemia |
P04637
(related)
|
| H00010 | Multiple myeloma |
P04637
(related)
|
| H00013 | Small cell lung cancer |
P04637
(related)
|
| H00014 | Non-small cell lung cancer |
P04637
(related)
|
| H00015 | Malignant pleural mesothelioma |
P04637
(related)
|
| H00016 | Oral cancer |
P04637
(related)
P04637 (marker) |
| H00017 | Esophageal cancer |
P04637
(related)
P04637 (marker) |
| H00018 | Gastric cancer |
P04637
(related)
|
| H00019 | Pancreatic cancer |
P04637
(related)
P04637 (marker) |
| H00020 | Colorectal cancer |
P04637
(related)
P04637 (marker) |
| H00022 | Bladder cancer |
P04637
(related)
|
| H00025 | Penile cancer |
P04637
(related)
P04637 (marker) |
| H00026 | Endometrial Cancer |
P04637
(related)
|
| H00027 | Ovarian cancer |
P04637
(related)
|
| H00028 | Choriocarcinoma |
P04637
(related)
|
| H00029 | Vulvar cancer |
P04637
(related)
|
| H00031 | Breast cancer |
P04637
(related)
|
| H00032 | Thyroid cancer |
P04637
(related)
|
| H00036 | Osteosarcoma |
P04637
(related)
P08684 (marker) |
| H00038 | Malignant melanoma |
P04637
(related)
|
| H00039 | Basal cell carcinoma |
P04637
(related)
|
| H00040 | Squamous cell carcinoma |
P04637
(related)
|
| H00041 | Kaposi's sarcoma |
P04637
(related)
|
| H00042 | Glioma |
P04637
(related)
P04637 (marker) |
| H00044 | Cancer of the anal canal |
P04637
(related)
|
| H00046 | Cholangiocarcinoma |
P04637
(related)
|
| H00047 | Gallbladder cancer |
P04637
(related)
|
| H00048 | Hepatocellular carcinoma |
P04637
(related)
|
| H00055 | Laryngeal cancer |
P04637
(related)
P04637 (marker) |
| H00881 | Li-Fraumeni syndrome |
P04637
(related)
|
| H01007 | Choroid plexus papilloma |
P04637
(related)
|
| H00021 | Renal cell carcinoma |
P04637
(marker)
|
| H01205 | Coumarin resistance |
P11712
(related)
|
| H01171 | Poor drug metabolism (PM) |
P33261
(related)
|
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
Q03164
(related)
Q03164 (marker) |
| H00002 | Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) |
Q03164
(related)
|
| H00063 | Spinocerebellar ataxia (SCA) |
Q99700
(related)
|