PCIDB

KNApSAcK Metabolite C00011324

Metabolite

KNApSAcK Entry

id C00011324
Name Zygosporin A / Cytochalasin D
CAS RN 22144-77-0
Standard InChI InChI=1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)/b13-9+,15-14+/t17?,18-,22+,23+,24+,25+,26-,29-,30-/m1/s1
Standard InChI (Main Layer) InChI=1S/C30H37NO6/c1-17-10-9-13-22-26(33)19(3)18(2)25-23(16-21-11-7-6-8-12-21)31-28(35)30(22,25)24(37-20(4)32)14-15-29(5,36)27(17)34/h6-9,11-15,17-18,22-26,33,36H,3,10,16H2,1-2,4-5H3,(H,31,35)

Cluster

Phytochemical cluster
KCF-S cluster No. 245

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL158762 CHEMBL260287 CHEMBL577455 CHEMBL1356553 CHEMBL1446029 CHEMBL1975837 CHEMBL2361294

KEGG

By LinkDB

CTD

By CAS RN D015638

Human Protein / Gene in interaction

15 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL1356553 CHEMBL1741321 (1)
1 / 0
P04637 Cellular tumor antigen p53 Transcription Factor CHEMBL1356553 CHEMBL1613992 (1)
7 / 44
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL1356553 CHEMBL1614027 (1) CHEMBL1741325 (1)
0 / 1
Q92830 Histone acetyltransferase KAT2A Enzyme CHEMBL1446029 CHEMBL1738606 (1)
0 / 0
P51843 Nuclear receptor subfamily 0 group B member 1 Nuclear hormone receptor subfamily 0 group B member 1 CHEMBL2361294 CHEMBL2354292 (1)
2 / 2
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL1356553 CHEMBL1613808 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL1356553 CHEMBL1741322 (1)
0 / 0
P16050 Arachidonate 15-lipoxygenase Enzyme CHEMBL1356553 CHEMBL1614240 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL1356553 CHEMBL1613777 (1) CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL1356553 CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL1741324 (1)
0 / 1
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1356553 CHEMBL1614250 (1)
4 / 3
O00255 Menin Unclassified protein CHEMBL1356553 CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL1356553 CHEMBL1614531 (1)
1 / 3
Q13951 Core-binding factor subunit beta Unclassified protein CHEMBL1446029 CHEMBL1613933 (1)
0 / 1
Q01196 Runt-related transcription factor 1 Unclassified protein CHEMBL1446029 CHEMBL1613933 (1)
1 / 6

CTD interaction (32)

compound gene gene name gene description interaction interaction type form reference
pmid
D015638 3577 CXCR1
C-C
C-C-CKR-1
CD128
CD181
CDw128a
CKR-1
CMKAR1
IL8R1
IL8RA
IL8RBA
chemokine (C-X-C motif) receptor 1 Cytochalasin D promotes the reaction [IL8 protein results in decreased expression of CXCR1 protein] decreases expression
/ increases reaction
protein 11145710
D015638 3579 CXCR2
CD182
CDw128b
CMKAR2
IL8R2
IL8RA
IL8RB
chemokine (C-X-C motif) receptor 2 Cytochalasin D promotes the reaction [IL8 protein results in decreased expression of CXCR2 protein] decreases expression
/ increases reaction
protein 11145710
D015638 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 Cytochalasin D inhibits the reaction [TNF protein affects the localization of ICAM1 protein] affects localization
/ decreases reaction
protein 15034928
D015638 3458 IFNG
IFG
IFI
interferon, gamma Cytochalasin D promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] affects cotreatment
/ increases expression
/ increases reaction
protein 12799187
D015638 3551 IKBKB
IKK-beta
IKK2
IKKB
NFKBIKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) Cytochalasin D results in decreased localization of [IKBKB protein binds to NFKBIA protein] affects binding
/ decreases localization
protein 17029595
D015638 3551 IKBKB
IKK-beta
IKK2
IKKB
NFKBIKB
inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10) Cytochalasin D results in increased phosphorylation of IKBKB protein increases phosphorylation
protein 17029595
D015638 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Silicon Dioxide] results in increased cleavage of and results in increased secretion of IL1B protein] affects cotreatment
/ decreases reaction
/ increases cleavage
/ increases secretion
protein 18604214
D015638 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Cytochalasin D inhibits the reaction [[Lipopolysaccharides co-treated with Uric Acid] results in increased cleavage of and results in increased secretion of IL1B protein] affects cotreatment
/ decreases reaction
/ increases cleavage
/ increases secretion
protein 18604214
D015638 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Cytochalasin D promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] affects cotreatment
/ increases expression
/ increases reaction
protein 12799187
D015638 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Cytochalasin D results in decreased chemical synthesis of IL6 protein decreases chemical synthesis
protein 16499908
D015638 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Cytochalasin D results in increased stability of IL6 mRNA increases stability
mRNA 16499908
D015638 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Cytochalasin D inhibits the reaction [Titanium results in increased secretion of IL8 protein] decreases reaction
/ increases secretion
protein 16392133
D015638 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Cytochalasin D promotes the reaction [IL8 protein results in decreased expression of CXCR1 protein] decreases expression
/ increases reaction
protein 11145710
D015638 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Cytochalasin D promotes the reaction [IL8 protein results in decreased expression of CXCR2 protein] decreases expression
/ increases reaction
protein 11145710
D015638 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Cytochalasin D results in increased stability of IL8 mRNA increases stability
mRNA 16499908
D015638 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) Cytochalasin D promotes the reaction [TNF results in increased expression of MMP9 mRNA] increases expression
/ increases reaction
mRNA 17560598
D015638 4776 NFATC4
NF-ATc4
NFAT3
nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4 Cytochalasin D results in decreased localization of NFATC4 protein decreases localization
protein 17044076
D015638 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Cytochalasin D results in decreased localization of [IKBKB protein binds to NFKBIA protein] affects binding
/ decreases localization
protein 17029595
D015638 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Cytochalasin D results in increased phosphorylation of NFKBIA protein increases phosphorylation
protein 17029595
D015638 4843 NOS2
HEP-NOS
INOS
NOS
NOS2A
nitric oxide synthase 2, inducible (EC:1.14.13.39) Cytochalasin D promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] affects cotreatment
/ increases expression
/ increases reaction
mRNA 12799187
D015638 3651 PDX1
GSF
IDX-1
IPF1
IUF1
MODY4
PDX-1
STF-1
pancreatic and duodenal homeobox 1 Cytochalasin D results in decreased uptake of PDX1 protein decreases uptake
protein 16405074
D015638 5327 PLAT
T-PA
TPA
plasminogen activator, tissue (EC:3.4.21.68) Cytochalasin D results in increased expression of PLAT increases expression
12371961
D015638 6247 RS1
RS
XLRS1
retinoschisin 1 Cytochalasin D results in decreased secretion of RS1 protein decreases secretion
protein 21738583
D015638 1317 SLC31A1
COPT1
CTR1
solute carrier family 31 (copper transporter), member 1 Cytochalasin D inhibits the reaction [Cisplatin results in increased degradation of SLC31A1 protein] decreases reaction
/ increases degradation
protein 17108132
D015638 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Cytochalasin D inhibits the reaction [TNF protein affects the localization of ICAM1 protein] affects localization
/ decreases reaction
protein 15034928
D015638 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Cytochalasin D inhibits the reaction [TNF protein affects the localization of VCAM1 protein] affects localization
/ decreases reaction
protein 15034928
D015638 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Cytochalasin D inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 15034928
D015638 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Cytochalasin D promotes the reaction [[IFNG protein co-treated with IL1B protein co-treated with TNF protein] results in increased expression of NOS2 mRNA] affects cotreatment
/ increases expression
/ increases reaction
protein 12799187
D015638 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Cytochalasin D promotes the reaction [TNF results in increased expression of MMP9 mRNA] increases expression
/ increases reaction
17560598
D015638 7295 TXN
TRDX
TRX
TRX1
thioredoxin Cytochalasin D inhibits the reaction [Cadmium Chloride affects the localization of TXN protein] affects localization
/ decreases reaction
protein 22961094
D015638 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 Cytochalasin D inhibits the reaction [TNF protein affects the localization of VCAM1 protein] affects localization
/ decreases reaction
protein 15034928
D015638 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 Cytochalasin D inhibits the reaction [TNF protein results in increased expression of VCAM1 protein] decreases reaction
/ increases expression
protein 15034928

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (19)

OMIM preferred title UniProt
#300018 46,xy sex reversal 2; srxy2 P51843
#300200 Adrenal hypoplasia, congenital; ahc P51843
#202300 Adrenocortical carcinoma, hereditary; adcc P04637
#614740 Basal cell carcinoma, susceptibility to, 7; bcc7 P04637
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#133239 Esophageal cancer P04637
#600274 Frontotemporal dementia; ftd P10636
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#151623 Li-fraumeni syndrome 1; lfs1 P04637
#211980 Lung cancer P04637
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#260500 Papilloma of choroid plexus; cpp P04637
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#601399 Platelet disorder, familial, with associated myeloid malignancy Q01196
#275355 Squamous cell carcinoma, head and neck; hnscc P04637
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636

KEGG DISEASE (52)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
P04637 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00004 Chronic myeloid leukemia (CML) P04637 (related)
Q01196 (related)
H00005 Chronic lymphocytic leukemia (CLL) P04637 (related)
H00006 Hairy-cell leukemia P04637 (related)
H00008 Burkitt lymphoma P04637 (related)
H00009 Adult T-cell leukemia P04637 (related)
H00010 Multiple myeloma P04637 (related)
H00013 Small cell lung cancer P04637 (related)
H00014 Non-small cell lung cancer P04637 (related)
H00015 Malignant pleural mesothelioma P04637 (related)
H00016 Oral cancer P04637 (related)
P04637 (marker)
H00017 Esophageal cancer P04637 (related)
P04637 (marker)
H00018 Gastric cancer P04637 (related)
H00019 Pancreatic cancer P04637 (related)
P04637 (marker)
H00020 Colorectal cancer P04637 (related)
P04637 (marker)
H00022 Bladder cancer P04637 (related)
H00025 Penile cancer P04637 (related)
P04637 (marker)
H00026 Endometrial Cancer P04637 (related)
H00027 Ovarian cancer P04637 (related)
H00028 Choriocarcinoma P04637 (related)
H00029 Vulvar cancer P04637 (related)
H00031 Breast cancer P04637 (related)
H00032 Thyroid cancer P04637 (related)
H00036 Osteosarcoma P04637 (related)
P08684 (marker)
H00038 Malignant melanoma P04637 (related)
H00039 Basal cell carcinoma P04637 (related)
H00040 Squamous cell carcinoma P04637 (related)
H00041 Kaposi's sarcoma P04637 (related)
H00042 Glioma P04637 (related)
P04637 (marker)
H00044 Cancer of the anal canal P04637 (related)
H00046 Cholangiocarcinoma P04637 (related)
H00047 Gallbladder cancer P04637 (related)
H00048 Hepatocellular carcinoma P04637 (related)
H00055 Laryngeal cancer P04637 (related)
P04637 (marker)
H00881 Li-Fraumeni syndrome P04637 (related)
H01007 Choroid plexus papilloma P04637 (related)
H00021 Renal cell carcinoma P04637 (marker)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00552 Glycerol kinase deficiency (GKD) P51843 (related)
H00607 46,XY disorders of sex development (Disorders of gonadal development) P51843 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q01196 (related)
Q01196 (marker)
Q03164 (related)
Q03164 (marker)
H00003 Acute myeloid leukemia (AML) Q01196 (related)
Q01196 (marker)
Q13951 (marker)
H00978 Thrombocytopenia (THC) Q01196 (related)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D009436 D015638 Neural Tube Defects marker/mechanism
3135633