KCF-S cluster No. 245 (24 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (24)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count

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Cumulative family count

class name	count
Xylariaceae	11
Valsaceae	10
Clavicipitaceae	3
Didymellaceae	2
Diaporthaceae	2
Amphisphaeriaceae	1
Coriolaceae	1
Magnaporthaceae	1

KEGG BRITE br08003

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Categories (0)

br08003 Category	# of metabolite

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metabolites link (0)

br08003 Category	KEGG ID	KNApSAcK ID

Metabolite list (24)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00011323	Cytochalasin C	CHEMBL156205	C031582
C00011324	Zygosporin A / Cytochalasin D	CHEMBL158762 CHEMBL260287 CHEMBL577455 CHEMBL1356553 CHEMBL1446029 CHEMBL1975837 CHEMBL2361294	D015638	15 / 19 / 52	19 / 1
C00011328	Zygosporin D / Deacetylzygosporin A / Desacetylcytochalasin D	CHEMBL481643
C00011332	Paspalin-P / Cytochalasin H / Kodocytochalasin 1	CHEMBL75141 CHEMBL1702179 CHEMBL2003636	C034891	6 / 1 / 4
C00011333	Cytochalasin U
C00011334	Paspalin P-2 / Cytochalasin J / Kodocytochalasin 2 / Deacetylcytochalasin H		C029235
C00011335	Epoxycytochalasin H	CHEMBL517645 CHEMBL1400532		5 / 6 / 2
C00011336	Epoxycytochalasin J / Epoxydeacetylcytochalasin H / Deacetylepoxycytochalasin H
C00011337	Engleromycin
C00011338	Pyrichalasin H
C00011339	Cytochalasin Npho	CHEMBL1362391		3 / 1 / 0
C00011340	Cytochalasin Opho
C00011347	Cytochalasin Ppho	CHEMBL1900301		2 / 0 / 0
C00011348	Cytochalasin Qpho
C00011349	Cytochalasin Rpho
C00011350	Cytochalasin S	CHEMBL1869180		1 / 0 / 0
C00011351	Cytochalasin Ohyp
C00011352	Cytochalasin Qhyp	CHEMBL299905
C00017263	L 696475
C00017264	L 696474 / 18-Deoxycytochalasin H	CHEMBL515324	C075543
C00017265	L 697318
C00024787	Cytochalasin Q	CHEMBL299905
C00027702	19,20-Epoxycytochalasin D
C00042920	RKS-1778	CHEMBL517485

Human Protein / Gene in interactions

26 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
O75496	Geminin	Unclassified protein	C00011332 C00011335 C00011339 C00011350	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00011332 C00011335 C00011339	0 / 0
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00011332 C00011335	0 / 0
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00011324	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00011324	0 / 1
Q92830	Histone acetyltransferase KAT2A	Enzyme	C00011324	0 / 0
P84022	Mothers against decapentaplegic homolog 3	Unclassified protein	C00011335	2 / 0
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00011324	1 / 0
P38398	Breast cancer type 1 susceptibility protein	Enzyme	C00011335	4 / 2
Q99700	Ataxin-2	Unclassified protein	C00011332	1 / 1
P83916	Chromobox protein homolog 1	Unclassified protein	C00011347	0 / 0
P51843	Nuclear receptor subfamily 0 group B member 1	Nuclear hormone receptor subfamily 0 group B member 1	C00011324	2 / 2
P28482	Mitogen-activated protein kinase 1	Erk	C00011324	0 / 0
P33765	Adenosine receptor A3	Adenosine receptor	C00011332	0 / 0
P16050	Arachidonate 15-lipoxygenase	Enzyme	C00011324	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00011324	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00011324	0 / 1
Q9UNA4	DNA polymerase iota	Enzyme	C00011347	0 / 0
P10636	Microtubule-associated protein tau	Unclassified protein	C00011324	4 / 3
P04637	Cellular tumor antigen p53	Transcription Factor	C00011324	7 / 37
O75874	Isocitrate dehydrogenase [NADP] cytoplasmic	Enzyme	C00011339	1 / 0
O00255	Menin	Unclassified protein	C00011324	2 / 5
Q03164	Histone-lysine N-methyltransferase 2A	Enzyme	C00011324	1 / 2
Q13951	Core-binding factor subunit beta	Unclassified protein	C00011324	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00011324	1 / 4
P01215	Glycoprotein hormones alpha chain	Unclassified protein	C00011332	0 / 3

19 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
3577	CXCR1, C-C, C-C-CKR-1, CD128, CD181, CDw128a, CKR-1, CMKAR1, IL8R1, IL8RA, IL8RBA	chemokine (C-X-C motif) receptor 1	C00011324
3579	CXCR2, CD182, CDw128b, CMKAR2, IL8R2, IL8RA, IL8RB	chemokine (C-X-C motif) receptor 2	C00011324
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00011324
3458	IFNG, IFG, IFI	interferon, gamma	C00011324
3551	IKBKB, IKK-beta, IKK2, IKKB, NFKBIKB	inhibitor of kappa light polypeptide gene enhancer in B-cells, kinase beta (EC:2.7.11.10)	C00011324
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00011324
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00011324
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00011324
4318	MMP9, CLG4B, GELB, MANDP2, MMP-9	matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35)	C00011324
4776	NFATC4, NF-ATc4, NFAT3	nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 4	C00011324
4792	NFKBIA, IKBA, MAD-3, NFKBI	nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha	C00011324
4843	NOS2, HEP-NOS, INOS, NOS, NOS2A	nitric oxide synthase 2, inducible (EC:1.14.13.39)	C00011324
3651	PDX1, GSF, IDX-1, IPF1, IUF1, MODY4, PDX-1, STF-1	pancreatic and duodenal homeobox 1	C00011324
5327	PLAT, T-PA, TPA	plasminogen activator, tissue (EC:3.4.21.68)	C00011324
6247	RS1, RS, XLRS1	retinoschisin 1	C00011324
1317	SLC31A1, COPT1, CTR1	solute carrier family 31 (copper transporter), member 1	C00011324
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00011324
7295	TXN, TRDX, TRX, TRX1	thioredoxin	C00011324
7412	VCAM1, CD106, INCAM-100	vascular cell adhesion molecule 1	C00011324

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions