PCIDB

KNApSAcK Metabolite C00011359

Metabolite

KNApSAcK Entry

id C00011359
Name Aspochalasin C
CAS RN 72401-79-7
Standard InChI InChI=1S/C24H35NO4/c1-13(2)10-18-22-16(5)15(4)12-17-11-14(3)6-7-19(26)20(27)8-9-21(28)24(17,22)23(29)25-18/h8-9,11-13,16-20,22,26-27H,6-7,10H2,1-5H3,(H,25,29)/b9-8+,14-11+/t16-,17+,18+,19+,20+,22+,24-/m1/s1
Standard InChI (Main Layer) InChI=1S/C24H35NO4/c1-13(2)10-18-22-16(5)15(4)12-17-11-14(3)6-7-19(26)20(27)8-9-21(28)24(17,22)23(29)25-18/h8-9,11-13,16-20,22,26-27H,6-7,10H2,1-5H3,(H,25,29)

Cluster

Phytochemical cluster
KCF-S cluster No. 593

Link

ChEMBL

By standard InChI CHEMBL519431
By standard InChI Main Layer CHEMBL519431 CHEMBL479328 CHEMBL1981103

KEGG

By LinkDB

CTD

By CAS RN

Human Protein / Gene in interaction

27 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P17861 X-box-binding protein 1 Unclassified protein CHEMBL1981103 CHEMBL1738682 (1)
1 / 0
Q99700 Ataxin-2 Unclassified protein CHEMBL1981103 CHEMBL2114784 (1)
1 / 1
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL1981103 CHEMBL1794499 (1)
2 / 0
Q9HC97 G-protein coupled receptor 35 Kynurenic acid receptor CHEMBL1981103 CHEMBL1613835 (1)
0 / 0
P11473 Vitamin D3 receptor NR1I1 CHEMBL1981103 CHEMBL1794311 (1) CHEMBL1963865 (1)
CHEMBL1963915 (1) CHEMBL1963934 (1)
CHEMBL1963947 (1)
2 / 3
O95977 Sphingosine 1-phosphate receptor 4 EDG receptor CHEMBL1981103 CHEMBL1614498 (1)
0 / 0
P21453 Sphingosine 1-phosphate receptor 1 EDG receptor CHEMBL1981103 CHEMBL1614525 (1)
0 / 0
P42858 Huntingtin Unclassified protein CHEMBL1981103 CHEMBL1613918 (1)
1 / 1
P84022 Mothers against decapentaplegic homolog 3 Unclassified protein CHEMBL1981103 CHEMBL1794584 (1)
2 / 0
O75496 Geminin Unclassified protein CHEMBL1981103 CHEMBL2114843 (1) CHEMBL2114780 (1)
0 / 0
P51151 Ras-related protein Rab-9A Unclassified protein CHEMBL1981103 CHEMBL1613838 (1)
0 / 0
P38398 Breast cancer type 1 susceptibility protein Enzyme CHEMBL1981103 CHEMBL2114807 (1)
4 / 2
Q9Y2T6 G-protein coupled receptor 55 Lysophosphatidylinositol receptor CHEMBL1981103 CHEMBL1737910 (1)
0 / 0
P43220 Glucagon-like peptide 1 receptor Glucagon-like peptide receptor CHEMBL1981103 CHEMBL2114788 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL1981103 CHEMBL1794401 (1)
0 / 0
Q9HC16 DNA dC->dU-editing enzyme APOBEC-3G Enzyme CHEMBL1981103 CHEMBL1963863 (1)
0 / 0
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL1981103 CHEMBL1614521 (1)
0 / 0
O15118 Niemann-Pick C1 protein Unclassified protein CHEMBL1981103 CHEMBL1614342 (1)
1 / 1
O75030 Microphthalmia-associated transcription factor Unclassified protein CHEMBL1981103 CHEMBL1738549 (1) CHEMBL1738553 (1)
CHEMBL1738671 (1) CHEMBL1737866 (1)
CHEMBL1738318 (1)
4 / 5
Q96QE3 ATPase family AAA domain-containing protein 5 Unclassified protein CHEMBL1981103 CHEMBL1738588 (1)
0 / 0
Q6W5P4 Neuropeptide S receptor Neuropeptide receptor CHEMBL1981103 CHEMBL1614052 (1)
1 / 0
P10636 Microtubule-associated protein tau Unclassified protein CHEMBL1981103 CHEMBL1614421 (1)
4 / 3
Q16236 Nuclear factor erythroid 2-related factor 2 Unclassified protein CHEMBL1981103 CHEMBL1738184 (1) CHEMBL2114908 (1)
0 / 0
Q9GZV3 High affinity choline transporter 1 Choline Na-symporter CHEMBL1981103 CHEMBL1794362 (1) CHEMBL1794546 (1)
1 / 0
O75874 Isocitrate dehydrogenase [NADP] cytoplasmic Enzyme CHEMBL1981103 CHEMBL2354311 (1)
1 / 0
O00255 Menin Unclassified protein CHEMBL1981103 CHEMBL1614257 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL1981103 CHEMBL1614257 (1)
1 / 3

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (28)

OMIM preferred title UniProt
#103470 Albinism, ocular, with sensorineural deafness O75030
#608584 Asthma-related traits, susceptibility to, 2 Q6W5P4
#114480 Breast cancer P38398
#604370 Breast-ovarian cancer, familial, susceptibility to, 1; brovca1 P38398
#114500 Colorectal cancer; crc P84022
#600274 Frontotemporal dementia; ftd P10636
#137800 Glioma susceptibility 1; glm1 O75874
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#143100 Huntington disease; hd P42858
#145000 Hyperparathyroidism 1; hrpt1 O00255
#613795 Loeys-dietz syndrome, type 3; lds3 P84022
#612371 Major affective disorder 7; mafd7 P17861
#614456 Melanoma, cutaneous malignant, susceptibility to, 8; cmm8 O75030
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#607948 Mycobacterium tuberculosis, susceptibility to P11473
#158580 Neuronopathy, distal hereditary motor, type viia; hmn7a Q9GZV3
#257220 Niemann-pick disease, type c1; npc1 O15118
#167000 Ovarian cancer P38398
#614320 Pancreatic cancer, susceptibility to, 4; pnca4 P38398
#260540 Parkinson-dementia syndrome P10636
#172700 Pick disease of brain P10636
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#183090 Spinocerebellar ataxia 2; sca2 Q99700
#601104 Supranuclear palsy, progressive, 1; psnp1 P10636
#103500 Tietz syndrome O75030
#277440 Vitamin d-dependent rickets, type 2a; vddr2a P11473
#193510 Waardenburg syndrome, type 2a; ws2a O75030

KEGG DISEASE (22)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00136 Niemann-Pick disease type C (NPC) O15118 (related)
H00038 Malignant melanoma O75030 (related)
O75030 (marker)
H00169 Ocular albinism O75030 (related)
H00759 Waardenburg syndrome (WS) O75030 (related)
H01187 Tietz syndrome O75030 (related)
H00058 Amyotrophic lateral sclerosis (ALS) P10636 (related)
H00077 Progressive supranuclear palsy (PSP) P10636 (related)
H00078 Frontotemporal lobar degeneration (FTLD) P10636 (related)
H00342 Tuberculosis P11473 (related)
H00784 Localized autosomal recessive hypotrichosis P11473 (related)
H01143 Vitamin D-dependent rickets P11473 (related)
H00027 Ovarian cancer P38398 (related)
H00031 Breast cancer P38398 (related)
H00059 Huntington's disease (HD) P42858 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q99700 (related)