PCIDB

KNApSAcK Metabolite C00001195

Metabolite

KNApSAcK Entry

id C00001195
Name Mevalonic acid
CAS RN 150-97-0
Standard InChI InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)/t6-/m1/s1
Standard InChI (Main Layer) InChI=1S/C6H12O4/c1-6(10,2-3-7)4-5(8)9/h7,10H,2-4H2,1H3,(H,8,9)

Cluster

Phytochemical cluster
KCF-S cluster No. 6424

Link

ChEMBL

By standard InChI CHEMBL1794734
By standard InChI Main Layer CHEMBL1794734

KEGG

By LinkDB C00418

CTD

By CAS RN D008798

Species

Summary

Plant class

class name count
rosids 1

Family

family name count
Brassicaceae 1

List (1)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Arabidopsis thaliana 3702 Brassicaceae rosids Viridiplantae

Human Protein / Gene in interaction

CTD interaction (160)

compound gene gene name gene description interaction interaction type form reference
pmid
D008798 27113 BBC3
JFY-1
JFY1
PUMA
BCL2 binding component 3 Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of BBC3 protein] decreases reaction
/ increases expression
protein 20045437
D008798 596 BCL2
Bcl-2
PPP1R50
B-cell CLL/lymphoma 2 Mevalonic Acid inhibits the reaction [Lovastatin results in decreased expression of BCL2 protein] decreases expression
/ decreases reaction
protein 12094262
D008798 650 BMP2
BDA2
BMP2A
bone morphogenetic protein 2 Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of BMP2 mRNA] decreases reaction
/ increases expression
mRNA 10814523
D008798 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Mevalonic Acid inhibits the reaction [atorvastatin results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 16470222
D008798 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Mevalonic Acid inhibits the reaction [cerivastatin results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 16470222
D008798 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of CASP3 protein] decreases reaction
/ increases activity
protein 16470222
17428261
20427495
D008798 836 CASP3
CPP32
CPP32B
SCA-1
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of CASP3 protein] decreases reaction
/ increases expression
protein 15949312
D008798 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Mevalonic Acid inhibits the reaction [Simvastatin results in increased activity of CASP7 protein] decreases reaction
/ increases activity
protein 20427495
D008798 840 CASP7
CASP-7
CMH-1
ICE-LAP3
LICE2
MCH3
caspase 7, apoptosis-related cysteine peptidase (EC:3.4.22.60) Mevalonic Acid inhibits the reaction [Simvastatin results in increased cleavage of CASP7 protein] decreases reaction
/ increases cleavage
protein 20045437
D008798 842 CASP9
APAF-3
APAF3
ICE-LAP6
MCH6
PPP1R56
caspase 9, apoptosis-related cysteine peptidase (EC:3.4.22.62) Mevalonic Acid inhibits the reaction [Simvastatin results in increased cleavage of CASP9 protein] decreases reaction
/ increases cleavage
protein 20045437
D008798 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Mevalonic Acid inhibits the reaction [atorvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]] decreases reaction
/ increases expression
mRNA 12117737
D008798 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Mevalonic Acid inhibits the reaction [atorvastatin results in decreased expression of CCL2 mRNA] decreases expression
/ decreases reaction
mRNA 12117737
D008798 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]] decreases reaction
/ increases expression
mRNA 12117737
D008798 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]] decreases reaction
/ increases expression
mRNA 16321392
D008798 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]] decreases reaction
/ increases expression
mRNA 12117737
16321392
D008798 6347 CCL2
GDCF-2
HC11
HSMCR30
MCAF
MCP-1
MCP1
SCYA2
SMC-CF
chemokine (C-C motif) ligand 2 Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CCL2 mRNA] decreases expression
/ decreases reaction
mRNA 12117737
D008798 6348 CCL3
G0S19-1
LD78ALPHA
MIP-1-alpha
MIP1A
SCYA3
chemokine (C-C motif) ligand 3 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL3 mRNA]] decreases reaction
/ increases expression
mRNA 16321392
D008798 6351 CCL4
ACT2
AT744.1
G-26
HC21
LAG-1
LAG1
MIP-1-beta
MIP1B
MIP1B1
SCYA2
SCYA4
chemokine (C-C motif) ligand 4 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL4 mRNA]] decreases reaction
/ increases expression
mRNA 16321392
D008798 6351 CCL4
ACT2
AT744.1
G-26
HC21
LAG-1
LAG1
MIP-1-beta
MIP1B
MIP1B1
SCYA2
SCYA4
chemokine (C-C motif) ligand 4 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL4 mRNA]] decreases reaction
/ increases expression
mRNA 16321392
D008798 1230 CCR1
CD191
CKR-1
CKR1
CMKBR1
HM145
MIP1aR
SCYAR1
chemokine (C-C motif) receptor 1 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]] decreases reaction
/ increases expression
mRNA 16321392
D008798 729230 CCR2
CC-CKR-2
CCR-2
CCR2A
CCR2B
CD192
CKR2
CKR2A
CKR2B
CMKBR2
MCP-1-R
chemokine (C-C motif) receptor 2 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]] decreases reaction
/ increases expression
mRNA 16321392
D008798 1233 CCR4
CC-CKR-4
CD194
CKR4
CMKBR4
ChemR13
HGCN:14099
K5-5
chemokine (C-C motif) receptor 4 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCR4 mRNA]] decreases reaction
/ increases expression
mRNA 16321392
D008798 1234 CCR5
CC-CKR-5
CCCKR5
CCR-5
CD195
CKR-5
CKR5
CMKBR5
IDDM22
chemokine (C-C motif) receptor 5 (gene/pseudogene) Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]] decreases reaction
/ increases expression
mRNA 16321392
D008798 959 CD40LG
CD154
CD40L
HIGM1
IGM
IMD3
T-BAM
TNFSF5
TRAP
gp39
hCD40L
CD40 ligand Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CD40LG results in increased expression of VCAM1 mRNA]] decreases reaction
/ increases expression
18269829
D008798 960 CD44
CDW44
CSPG8
ECMR-III
HCELL
HUTCH-I
IN
LHR
MC56
MDU2
MDU3
MIC4
Pgp1
CD44 molecule (Indian blood group) Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of CD44 protein] decreases expression
/ decreases reaction
protein 21199873
D008798 1063 CENPF
CENF
PRO1779
hcp-1
centromere protein F, 350/400kDa Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of CENPF protein] decreases reaction
/ increases expression
protein 12467231
D008798 1063 CENPF
CENF
PRO1779
hcp-1
centromere protein F, 350/400kDa Mevalonic Acid inhibits the reaction [Paclitaxel results in increased expression of CENPF protein] decreases reaction
/ increases expression
protein 12467231
D008798 1277 COL1A1
OI4
collagen, type I, alpha 1 Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of COL1A1 mRNA] decreases expression
/ decreases reaction
mRNA 16575855
D008798 1401 CRP
PTX1
C-reactive protein, pentraxin-related Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]] decreases reaction
/ increases expression
18023360
D008798 1401 CRP
PTX1
C-reactive protein, pentraxin-related Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]] decreases reaction
/ increases secretion
18023360
D008798 1906 EDN1
ET1
HDLCQ7
PPET1
endothelin 1 Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 mRNA] decreases expression
/ decreases reaction
mRNA 18390205
D008798 1906 EDN1
ET1
HDLCQ7
PPET1
endothelin 1 Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of EDN1 protein] decreases expression
/ decreases reaction
protein 18390205
D008798 2152 F3
CD142
TF
TFA
coagulation factor III (thromboplastin, tissue factor) Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of F3] decreases expression
/ decreases reaction
12753293
D008798 3122 HLA-DRA
HLA-DRA1
MLRW
major histocompatibility complex, class II, DR alpha Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA protein]] decreases reaction
/ increases expression
protein 11219190
D008798 3156 HMGCR
LDLCQ3
3-hydroxy-3-methylglutaryl-CoA reductase (EC:1.1.1.34) [25-hydroxycholesterol co-treated with Mevalonic Acid] results in increased ubiquitination of HMGCR protein affects cotreatment
/ increases ubiquitination
protein 21944868
D008798 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of ICAM1 mRNA]] decreases reaction
/ increases expression
mRNA 20863785
D008798 3383 ICAM1
BB2
CD54
P3.58
intercellular adhesion molecule 1 Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]] decreases reaction
/ increases expression
/ increases reaction
protein 10946302
D008798 3458 IFNG
IFG
IFI
interferon, gamma Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL2 mRNA]] decreases reaction
/ increases expression
16321392
D008798 3458 IFNG
IFG
IFI
interferon, gamma Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL3 mRNA]] decreases reaction
/ increases expression
16321392
D008798 3458 IFNG
IFG
IFI
interferon, gamma Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCL4 mRNA]] decreases reaction
/ increases expression
16321392
D008798 3458 IFNG
IFG
IFI
interferon, gamma Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR1 mRNA]] decreases reaction
/ increases expression
16321392
D008798 3458 IFNG
IFG
IFI
interferon, gamma Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR2 mRNA]] decreases reaction
/ increases expression
16321392
D008798 3458 IFNG
IFG
IFI
interferon, gamma Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of CCR5 mRNA]] decreases reaction
/ increases expression
16321392
D008798 3458 IFNG
IFG
IFI
interferon, gamma Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of HLA-DRA protein]] decreases reaction
/ increases expression
11219190
D008798 3458 IFNG
IFG
IFI
interferon, gamma Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 mRNA]] decreases reaction
/ increases expression
19589242
D008798 3458 IFNG
IFG
IFI
interferon, gamma Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 protein]] decreases reaction
/ increases expression
19589242
D008798 3458 IFNG
IFG
IFI
interferon, gamma Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 mRNA]] decreases reaction
/ increases expression
19589242
D008798 3458 IFNG
IFG
IFI
interferon, gamma Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 protein]] decreases reaction
/ increases expression
19589242
D008798 3605 IL17A
CTLA8
IL-17
IL-17A
IL17
interleukin 17A Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IL17A mRNA] decreases expression
/ decreases reaction
mRNA 18453621
D008798 3552 IL1A
IL-1A
IL1
IL1-ALPHA
IL1F1
interleukin 1, alpha Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]] affects cotreatment
/ decreases reaction
/ increases secretion
15728660
D008798 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]] decreases reaction
/ increases secretion
protein 17075836
D008798 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of ICAM1 protein]] decreases reaction
/ increases expression
/ increases reaction
protein 10946302
D008798 3553 IL1B
IL-1
IL1-BETA
IL1F2
interleukin 1, beta Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] decreases reaction
/ increases expression
/ increases reaction
protein 10946302
D008798 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Mevalonic Acid inhibits the reaction [atorvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]] decreases reaction
/ increases expression
mRNA 12117737
D008798 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Mevalonic Acid inhibits the reaction [atorvastatin results in decreased expression of IL6 mRNA] decreases expression
/ decreases reaction
mRNA 12117737
D008798 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]] decreases reaction
/ increases expression
mRNA 12117737
D008798 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA mRNA]] decreases reaction
/ increases expression
16424782
D008798 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA protein]] decreases reaction
/ increases expression
16424782
D008798 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]] decreases reaction
/ increases expression
mRNA 12117737
16511915
D008798 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]] decreases reaction
/ increases secretion
protein 17075836
D008798 3569 IL6
BSF2
HGF
HSF
IFNB2
IL-6
interleukin 6 (interferon, beta 2) Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IL6 mRNA] decreases expression
/ decreases reaction
mRNA 12117737
D008798 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Mevalonic Acid inhibits the reaction [atorvastatin inhibits the reaction [TNF results in increased expression of IL8 mRNA]] decreases reaction
/ increases expression
mRNA 12117737
D008798 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Mevalonic Acid inhibits the reaction [atorvastatin results in decreased expression of IL8 mRNA] decreases expression
/ decreases reaction
mRNA 12117737
D008798 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of IL8 mRNA]] decreases reaction
/ increases expression
mRNA 12117737
D008798 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL8 mRNA]] decreases reaction
/ increases expression
mRNA 12117737
16511915
D008798 3576 IL8
CXCL8
GCP-1
GCP1
LECT
LUCT
LYNAP
MDNCF
MONAP
NAF
NAP-1
NAP1
interleukin 8 Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of IL8 mRNA] decreases expression
/ decreases reaction
mRNA 12117737
D008798 10365 KLF2
LKLF
Kruppel-like factor 2 Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of KLF2 mRNA] decreases reaction
/ increases expression
mRNA 20493886
D008798 5594 MAPK1
ERK
ERK2
ERT1
MAPK2
P42MAPK
PRKM1
PRKM2
p38
p40
p41
p41mapk
mitogen-activated protein kinase 1 (EC:2.7.11.24) Mevalonic Acid inhibits the reaction [atorvastatin results in decreased phosphorylation of MAPK1 protein] decreases phosphorylation
/ decreases reaction
protein 16470222
D008798 5595 MAPK3
ERK-1
ERK1
ERT2
HS44KDAP
HUMKER1A
P44ERK1
P44MAPK
PRKM3
p44-ERK1
p44-MAPK
mitogen-activated protein kinase 3 (EC:2.7.11.24) Mevalonic Acid inhibits the reaction [atorvastatin results in decreased phosphorylation of MAPK3 protein] decreases phosphorylation
/ decreases reaction
protein 16470222
D008798 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Lipopolysaccharides results in increased secretion of MMP1 protein]] decreases reaction
/ increases secretion
protein 18625914
D008798 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of MMP1 mRNA] decreases expression
/ decreases reaction
mRNA 17303772
D008798 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of MMP1 protein] decreases expression
/ decreases reaction
protein 17303772
D008798 4312 MMP1
CLG
CLGN
matrix metallopeptidase 1 (interstitial collagenase) (EC:3.4.24.7) Mevalonic Acid inhibits the reaction [Simvastatin results in decreased secretion of MMP1 protein] decreases reaction
/ decreases secretion
protein 17303772
D008798 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]] affects cotreatment
/ decreases reaction
/ increases secretion
protein 15728660
D008798 4318 MMP9
CLG4B
GELB
MANDP2
MMP-9
matrix metallopeptidase 9 (gelatinase B, 92kDa gelatinase, 92kDa type IV collagenase) (EC:3.4.24.35) Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Tetradecanoylphorbol Acetate results in increased secretion of MMP9 protein]] decreases reaction
/ increases secretion
protein 15728660
D008798 4586 MUC5AC
MUC5
TBM
leB
mucin 5AC, oligomeric mucus/gel-forming Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [Acrolein results in increased expression of MUC5AC protein]] decreases reaction
/ increases expression
protein 20359552
D008798 4790 NFKB1
EBP-1
KBF1
NF-kB1
NF-kappa-B
NF-kappaB
NFKB-p105
NFKB-p50
NFkappaB
p105
p50
nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]] affects binding
/ decreases reaction
/ increases activity
protein 17277159
D008798 4792 NFKBIA
IKBA
MAD-3
NFKBI
nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]] decreases reaction
/ increases degradation
protein 17075836
D008798 4846 NOS3
ECNOS
eNOS
nitric oxide synthase 3 (endothelial cell) (EC:1.14.13.39) Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of NOS3 mRNA] decreases reaction
/ increases expression
mRNA 20493886
D008798 8013 NR4A3
CHN
CSMF
MINOR
NOR1
TEC
nuclear receptor subfamily 4, group A, member 3 Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of NR4A3 mRNA] decreases expression
/ decreases reaction
mRNA 16005304
D008798 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]] decreases reaction
/ increases cleavage
/ increases reaction
protein 21910007
D008798 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) Mevalonic Acid inhibits the reaction [Simvastatin results in increased cleavage of PARP1 protein] decreases reaction
/ increases cleavage
protein 20045437
D008798 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) Mevalonic Acid inhibits the reaction [TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]] decreases reaction
/ increases cleavage
/ increases reaction
protein 21910007
D008798 5155 PDGFB
IBGC5
PDGF-2
PDGF2
SIS
SSV
c-sis
platelet-derived growth factor beta polypeptide Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [[IL1A co-treated with PDGFB] results in increased secretion of MMP9 protein]] affects cotreatment
/ decreases reaction
/ increases secretion
15728660
D008798 5155 PDGFB
IBGC5
PDGF-2
PDGF2
SIS
SSV
c-sis
platelet-derived growth factor beta polypeptide Mevalonic Acid inhibits the reaction [Simvastatin results in decreased activity of PDGFB protein] decreases activity
/ decreases reaction
protein 8231022
D008798 5327 PLAT
T-PA
TPA
plasminogen activator, tissue (EC:3.4.21.68) Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PLAT] decreases reaction
/ increases expression
12753293
D008798 5327 PLAT
T-PA
TPA
plasminogen activator, tissue (EC:3.4.21.68) Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PLAT mRNA] decreases reaction
/ increases expression
mRNA 12371961
D008798 5444 PON1
ESA
MVCD5
PON
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) Mevalonic Acid inhibits the reaction [pitavastatin results in increased expression of PON1 mRNA] decreases reaction
/ increases expression
mRNA 15690306
D008798 5444 PON1
ESA
MVCD5
PON
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]] affects binding
/ decreases reaction
/ increases reaction
promoter 14500290
D008798 5444 PON1
ESA
MVCD5
PON
paraoxonase 1 (EC:3.1.1.2 3.1.8.1 3.1.1.81) Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of PON1 mRNA] decreases reaction
/ increases expression
mRNA 14500290
D008798 5465 PPARA
NR1C1
PPAR
PPARalpha
hPPAR
peroxisome proliferator-activated receptor alpha Mevalonic Acid inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] affects binding
/ decreases reaction
/ increases activity
/ increases reaction
protein 11779144
D008798 5743 PTGS2
COX-2
COX2
GRIPGHS
PGG/HS
PGHS-2
PHS-2
hCox-2
prostaglandin-endoperoxide synthase 2 (prostaglandin G/H synthase and cyclooxygenase) (EC:1.14.99.1) Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [sphingosine 1-phosphate results in increased expression of PTGS2 mRNA]] decreases reaction
/ increases expression
/ increases reaction
mRNA 18612546
D008798 5879 RAC1
Rac-1
TC-25
p21-Rac1
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) Mevalonic Acid inhibits the reaction [Lovastatin affects the localization of RAC1 protein] affects localization
/ decreases reaction
protein 12933658
D008798 5906 RAP1A
KREV-1
KREV1
RAP1
SMGP21
RAP1A, member of RAS oncogene family Mevalonic Acid affects the reaction [Menthol analog results in increased expression of RAP1A protein] affects reaction
/ increases expression
protein 12671036
D008798 5906 RAP1A
KREV-1
KREV1
RAP1
SMGP21
RAP1A, member of RAS oncogene family Mevalonic Acid affects the reaction [Menthol results in increased expression of RAP1A protein] affects reaction
/ increases expression
protein 12671036
D008798 5906 RAP1A
KREV-1
KREV1
RAP1
SMGP21
RAP1A, member of RAS oncogene family Mevalonic Acid affects the reaction [myrtenol results in increased expression of RAP1A protein] affects reaction
/ increases expression
protein 12671036
D008798 5906 RAP1A
KREV-1
KREV1
RAP1
SMGP21
RAP1A, member of RAS oncogene family Mevalonic Acid affects the reaction [perilla alcohol results in increased expression of RAP1A protein] affects reaction
/ increases expression
protein 12671036
D008798 5906 RAP1A
KREV-1
KREV1
RAP1
SMGP21
RAP1A, member of RAS oncogene family Mevalonic Acid affects the reaction [perillaldehyde results in increased expression of RAP1A protein] affects reaction
/ increases expression
protein 12671036
D008798 5970 RELA
NFKB3
p65
v-rel avian reticuloendotheliosis viral oncogene homolog A Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]] affects binding
/ decreases reaction
/ increases activity
protein 17277159
D008798 56729 RETN
ADSF
FIZZ3
RETN1
RSTN
XCP1
resistin Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased expression of RETN mRNA]] decreases reaction
/ increases expression
mRNA 18023360
D008798 56729 RETN
ADSF
FIZZ3
RETN1
RSTN
XCP1
resistin Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CRP results in increased secretion of RETN protein]] decreases reaction
/ increases secretion
protein 18023360
D008798 387 RHOA
ARH12
ARHA
RHO12
RHOH12
ras homolog family member A Mevalonic Acid affects the reaction [2-methyl-5-(1-methylethenyl)cyclohexanol results in increased expression of RHOA protein] affects reaction
/ increases expression
protein 12671036
D008798 387 RHOA
ARH12
ARHA
RHO12
RHOH12
ras homolog family member A Mevalonic Acid affects the reaction [carvone results in increased expression of RHOA protein] affects reaction
/ increases expression
protein 12671036
D008798 387 RHOA
ARH12
ARHA
RHO12
RHOH12
ras homolog family member A Mevalonic Acid affects the reaction [Menthol analog results in increased expression of RHOA protein] affects reaction
/ increases expression
protein 12671036
D008798 387 RHOA
ARH12
ARHA
RHO12
RHOH12
ras homolog family member A Mevalonic Acid affects the reaction [myrtenol results in increased expression of RHOA protein] affects reaction
/ increases expression
protein 12671036
D008798 387 RHOA
ARH12
ARHA
RHO12
RHOH12
ras homolog family member A Mevalonic Acid affects the reaction [perilla alcohol results in increased expression of RHOA protein] affects reaction
/ increases expression
protein 12671036
D008798 387 RHOA
ARH12
ARHA
RHO12
RHOH12
ras homolog family member A Mevalonic Acid affects the reaction [perillaldehyde results in increased expression of RHOA protein] affects reaction
/ increases expression
protein 12671036
D008798 387 RHOA
ARH12
ARHA
RHO12
RHOH12
ras homolog family member A Mevalonic Acid affects the reaction [perillic acid results in increased expression of RHOA protein] affects reaction
/ increases expression
protein 12671036
D008798 387 RHOA
ARH12
ARHA
RHO12
RHOH12
ras homolog family member A Mevalonic Acid inhibits the reaction [atorvastatin results in decreased activity of RHOA protein] decreases activity
/ decreases reaction
protein 16470222
D008798 387 RHOA
ARH12
ARHA
RHO12
RHOH12
ras homolog family member A Mevalonic Acid inhibits the reaction [atorvastatin results in increased localization of RHOA protein] decreases reaction
/ increases localization
protein 16470222
D008798 387 RHOA
ARH12
ARHA
RHO12
RHOH12
ras homolog family member A Mevalonic Acid inhibits the reaction [Lovastatin affects the localization of RHOA protein] affects localization
/ decreases reaction
protein 12933658
D008798 387 RHOA
ARH12
ARHA
RHO12
RHOH12
ras homolog family member A Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]] decreases reaction
/ increases activity
protein 17075836
D008798 387 RHOA
ARH12
ARHA
RHO12
RHOH12
ras homolog family member A Mevalonic Acid inhibits the reaction [Simvastatin results in decreased activity of RHOA protein] decreases activity
/ decreases reaction
protein 16470222
D008798 387 RHOA
ARH12
ARHA
RHO12
RHOH12
ras homolog family member A Mevalonic Acid inhibits the reaction [Simvastatin results in increased localization of RHOA protein] decreases reaction
/ increases localization
protein 16005304
16470222
D008798 388 RHOB
ARH6
ARHB
MST081
MSTP081
RHOH6
ras homolog family member B Mevalonic Acid affects the reaction [2-methyl-5-(1-methylethenyl)cyclohexanol results in increased expression of RHOB protein] affects reaction
/ increases expression
protein 12671036
D008798 388 RHOB
ARH6
ARHB
MST081
MSTP081
RHOH6
ras homolog family member B Mevalonic Acid affects the reaction [carveol results in increased expression of RHOB protein] affects reaction
/ increases expression
protein 12671036
D008798 388 RHOB
ARH6
ARHB
MST081
MSTP081
RHOH6
ras homolog family member B Mevalonic Acid affects the reaction [carvone results in increased expression of RHOB protein] affects reaction
/ increases expression
protein 12671036
D008798 388 RHOB
ARH6
ARHB
MST081
MSTP081
RHOH6
ras homolog family member B Mevalonic Acid affects the reaction [Menthol analog results in increased expression of RHOB protein] affects reaction
/ increases expression
protein 12671036
D008798 388 RHOB
ARH6
ARHB
MST081
MSTP081
RHOH6
ras homolog family member B Mevalonic Acid affects the reaction [Menthol results in increased expression of RHOB protein] affects reaction
/ increases expression
protein 12671036
D008798 388 RHOB
ARH6
ARHB
MST081
MSTP081
RHOH6
ras homolog family member B Mevalonic Acid affects the reaction [myrtenol results in increased expression of RHOB protein] affects reaction
/ increases expression
protein 12671036
D008798 388 RHOB
ARH6
ARHB
MST081
MSTP081
RHOH6
ras homolog family member B Mevalonic Acid affects the reaction [perilla alcohol results in increased expression of RHOB protein] affects reaction
/ increases expression
protein 12671036
D008798 388 RHOB
ARH6
ARHB
MST081
MSTP081
RHOH6
ras homolog family member B Mevalonic Acid affects the reaction [perillaldehyde results in increased expression of RHOB protein] affects reaction
/ increases expression
protein 12671036
D008798 388 RHOB
ARH6
ARHB
MST081
MSTP081
RHOH6
ras homolog family member B Mevalonic Acid affects the reaction [perillic acid results in increased expression of RHOB protein] affects reaction
/ increases expression
protein 12671036
D008798 6097 RORC
NR1F3
RORG
RZR-GAMMA
RZRG
TOR
RAR-related orphan receptor C Mevalonic Acid inhibits the reaction [Simvastatin results in decreased expression of RORC mRNA] decreases expression
/ decreases reaction
mRNA 18453621
D008798 6256 RXRA
NR2B1
retinoid X receptor, alpha Mevalonic Acid inhibits the reaction [cerivastatin promotes the reaction [Bezafibrate results in increased activity of [PPARA protein binds to RXRA protein]]] affects binding
/ decreases reaction
/ increases activity
/ increases reaction
protein 11779144
D008798 6401 SELE
CD62E
ELAM
ELAM1
ESEL
LECAM2
selectin E Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [IL1B protein results in increased expression of SELE protein]] decreases reaction
/ increases expression
/ increases reaction
protein 10946302
D008798 6721 SREBF2
SREBP-2
SREBP2
bHLHd2
sterol regulatory element binding transcription factor 2 Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [SREBF2 protein binds to PON1 promoter]] affects binding
/ decreases reaction
/ increases reaction
protein 14500290
D008798 6772 STAT1
CANDF7
ISGF-3
STAT91
signal transducer and activator of transcription 1, 91kDa Mevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of STAT1 protein] decreases phosphorylation
/ decreases reaction
protein 18453621
D008798 6774 STAT3
APRF
HIES
signal transducer and activator of transcription 3 (acute-phase response factor) Mevalonic Acid inhibits the reaction [Simvastatin results in decreased phosphorylation of STAT3 protein] decreases phosphorylation
/ decreases reaction
protein 18453621
D008798 7054 TH
DYT14
DYT5b
TYH
tyrosine hydroxylase (EC:1.14.16.2) Mevalonic Acid inhibits the reaction [Lovastatin results in increased expression of TH protein] decreases reaction
/ increases expression
protein 20694854
D008798 7056 THBD
AHUS6
BDCA3
CD141
THPH12
THRM
TM
thrombomodulin Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of THBD mRNA] decreases reaction
/ increases expression
mRNA 20493886
D008798 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Mevalonic Acid inhibits the reaction [atorvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]] decreases reaction
/ increases expression
12117737
D008798 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Mevalonic Acid inhibits the reaction [atorvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]] decreases reaction
/ increases expression
12117737
D008798 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Mevalonic Acid inhibits the reaction [atorvastatin inhibits the reaction [TNF results in increased expression of IL8 mRNA]] decreases reaction
/ increases expression
12117737
D008798 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]] decreases reaction
/ increases expression
12117737
D008798 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]] decreases reaction
/ increases expression
12117737
D008798 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Mevalonic Acid inhibits the reaction [cerivastatin inhibits the reaction [TNF results in increased expression of IL8 mRNA]] decreases reaction
/ increases expression
12117737
D008798 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF protein results in increased activity of [NFKB1 protein binds to RELA protein]]] affects binding
/ decreases reaction
/ increases activity
protein 17277159
D008798 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased activity of RHOA protein]] decreases reaction
/ increases activity
17075836
D008798 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased degradation of NFKBIA protein]] decreases reaction
/ increases degradation
17075836
D008798 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL2 mRNA]] decreases reaction
/ increases expression
12117737
16321392
D008798 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCL4 mRNA]] decreases reaction
/ increases expression
16321392
D008798 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of CCR4 mRNA]] decreases reaction
/ increases expression
16321392
D008798 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of ICAM1 mRNA]] decreases reaction
/ increases expression
20863785
D008798 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL6 mRNA]] decreases reaction
/ increases expression
12117737
16511915
D008798 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of IL8 mRNA]] decreases reaction
/ increases expression
12117737
16511915
D008798 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of VCAM1 mRNA]] decreases reaction
/ increases expression
20863785
D008798 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL1B protein]] decreases reaction
/ increases secretion
17075836
D008798 7124 TNF
DIF
TNF-alpha
TNFA
TNFSF2
tumor necrosis factor Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased secretion of IL6 protein]] decreases reaction
/ increases secretion
17075836
D008798 7293 TNFRSF4
ACT35
CD134
OX40
TXGP1L
tumor necrosis factor receptor superfamily, member 4 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 mRNA]] decreases reaction
/ increases expression
mRNA 19589242
D008798 7293 TNFRSF4
ACT35
CD134
OX40
TXGP1L
tumor necrosis factor receptor superfamily, member 4 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFRSF4 protein]] decreases reaction
/ increases expression
protein 19589242
D008798 8743 TNFSF10
APO2L
Apo-2L
CD253
TL2
TRAIL
tumor necrosis factor (ligand) superfamily, member 10 Mevalonic Acid inhibits the reaction [Simvastatin promotes the reaction [TNFSF10 protein results in increased cleavage of PARP1 protein]] decreases reaction
/ increases cleavage
/ increases reaction
protein 21910007
D008798 8743 TNFSF10
APO2L
Apo-2L
CD253
TL2
TRAIL
tumor necrosis factor (ligand) superfamily, member 10 Mevalonic Acid inhibits the reaction [TNFSF10 protein promotes the reaction [Simvastatin results in increased cleavage of PARP1 protein]] decreases reaction
/ increases cleavage
/ increases reaction
protein 21910007
D008798 7292 TNFSF4
CD134L
CD252
GP34
OX-40L
OX4OL
TXGP1
tumor necrosis factor (ligand) superfamily, member 4 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 mRNA]] decreases reaction
/ increases expression
mRNA 19589242
D008798 7292 TNFSF4
CD134L
CD252
GP34
OX-40L
OX4OL
TXGP1
tumor necrosis factor (ligand) superfamily, member 4 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IFNG results in increased expression of TNFSF4 protein]] decreases reaction
/ increases expression
protein 19589242
D008798 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [CD40LG results in increased expression of VCAM1 mRNA]] decreases reaction
/ increases expression
mRNA 18269829
D008798 7412 VCAM1
CD106
INCAM-100
vascular cell adhesion molecule 1 Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [TNF results in increased expression of VCAM1 mRNA]] decreases reaction
/ increases expression
mRNA 20863785
D008798 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA mRNA]] decreases reaction
/ increases expression
mRNA 16424782
D008798 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Mevalonic Acid inhibits the reaction [Simvastatin inhibits the reaction [IL6 results in increased expression of VEGFA protein]] decreases reaction
/ increases expression
protein 16424782
D008798 7422 VEGFA
MVCD1
VEGF
VPF
vascular endothelial growth factor A Mevalonic Acid inhibits the reaction [Simvastatin results in increased expression of VEGFA mRNA] decreases reaction
/ increases expression
mRNA 18356691