PCIDB

KNApSAcK Metabolite C00001379

Metabolite

KNApSAcK Entry

id C00001379
Name L-Methionine
CAS RN 63-68-3
Standard InChI InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
Standard InChI (Main Layer) InChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)

Cluster

Phytochemical cluster
KCF-S cluster No. 3595

Link

ChEMBL

By standard InChI CHEMBL42336
By standard InChI Main Layer CHEMBL274119 CHEMBL42336 CHEMBL1234268 CHEMBL1770614 CHEMBL2106977

KEGG

By LinkDB C00073

CTD

By CAS RN D008715

Species

Summary

Plant class

class name count
rosids 1

Family

family name count
Brassicaceae 1
Enterobacteriaceae 1

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Arabidopsis thaliana 3702 Brassicaceae rosids Viridiplantae
Escherichia coli 562 Enterobacteriaceae Bacteria

Human Protein / Gene in interaction

2 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL1234268 CHEMBL1794499 (1)
2 / 0
P49327 Fatty acid synthase Transferase CHEMBL42336 CHEMBL682484 (1)
0 / 0

CTD interaction (25)

compound gene gene name gene description interaction interaction type form reference
pmid
D008715 383 ARG1
arginase 1 (EC:3.5.3.1) Methionine inhibits the reaction [Benzo(a)pyrene results in increased expression of ARG1 protein] decreases reaction
/ increases expression
protein 22138271
D008715 396 ARHGDIA
GDIA1
NPHS8
RHOGDI
RHOGDI-1
Rho GDP dissociation inhibitor (GDI) alpha Methionine inhibits the reaction [Benzo(a)pyrene results in increased expression of ARHGDIA protein] decreases reaction
/ increases expression
protein 22138271
D008715 635 BHMT
BHMT1
betaine--homocysteine S-methyltransferase (EC:2.1.1.5) Methionine inhibits the reaction [BHMT protein results in increased metabolism of Vitamin U] decreases reaction
/ increases metabolic processing
protein 18230605
D008715 23743 BHMT2
betaine--homocysteine S-methyltransferase 2 (EC:2.1.1.10) Methionine inhibits the reaction [BHMT2 protein results in increased metabolism of Vitamin U] decreases reaction
/ increases metabolic processing
protein 18230605
D008715 883 CCBL1
GTK
KAT1
KATI
cysteine conjugate-beta lyase, cytoplasmic (EC:2.6.1.64 2.6.1.7 4.4.1.13) CCBL1 protein results in increased amination of Methionine increases amination
protein 22093698
D008715 1329 COX5B
COXVB
cytochrome c oxidase subunit Vb (EC:1.9.3.1) [Methionine deficiency co-treated with Homocysteine] affects the expression of COX5B protein affects cotreatment
/ affects expression
protein 17116298
D008715 1398 CRK
CRKII
p38
v-crk avian sarcoma virus CT10 oncogene homolog [Methionine deficiency co-treated with Homocysteine] affects the expression of CRK protein affects cotreatment
/ affects expression
protein 17116298
D008715 1508 CTSB
APPS
CPSB
cathepsin B (EC:3.4.22.1) Methionine inhibits the reaction [Benzo(a)pyrene results in increased expression of CTSB protein] decreases reaction
/ increases expression
protein 22138271
D008715 54512 EXOSC4
RRP41
RRP41A
Rrp41p
SKI6
Ski6p
hRrp41p
p12A
exosome component 4 [Methionine deficiency co-treated with Homocysteine] affects the expression of EXOSC4 protein affects cotreatment
/ affects expression
protein 17116298
D008715 2739 GLO1
GLOD1
GLYI
glyoxalase I (EC:4.4.1.5) Methionine inhibits the reaction [Benzo(a)pyrene results in decreased expression of GLO1 protein] decreases expression
/ decreases reaction
protein 22138271
D008715 2947 GSTM3
GST5
GSTB
GSTM3-3
GTM3
glutathione S-transferase mu 3 (brain) (EC:2.5.1.18) [Methionine deficiency co-treated with Homocysteine] affects the expression of GSTM3 protein affects cotreatment
/ affects expression
protein 17116298
D008715 2947 GSTM3
GST5
GSTB
GSTM3-3
GTM3
glutathione S-transferase mu 3 (brain) (EC:2.5.1.18) Methionine inhibits the reaction [Benzo(a)pyrene results in decreased expression of GSTM3 protein] decreases expression
/ decreases reaction
protein 22138271
D008715 9446 GSTO1
GSTO_1-1
GSTTLp28
P28
SPG-R
glutathione S-transferase omega 1 (EC:2.5.1.18 1.8.5.1 1.20.4.2) Methionine inhibits the reaction [Benzo(a)pyrene results in decreased expression of GSTO1 protein] decreases expression
/ decreases reaction
protein 22138271
D008715 3176 HNMT
HMT
HNMT-S1
HNMT-S2
histamine N-methyltransferase (EC:2.1.1.8) Methionine inhibits the reaction [Benzo(a)pyrene results in increased expression of HNMT protein] decreases reaction
/ increases expression
protein 22138271
D008715 5599 MAPK8
JNK
JNK-46
JNK1
JNK1A2
JNK21B1/2
PRKM8
SAPK1
SAPK1c
mitogen-activated protein kinase 8 (EC:2.7.11.24) Methionine deficiency results in increased activity of MAPK8 protein increases activity
protein 11880182
D008715 9588 PRDX6
1-Cys
AOP2
NSGPx
PRX
aiPLA2
p29
peroxiredoxin 6 (EC:1.11.1.9 1.11.1.15) [Methionine deficiency co-treated with Homocysteine] affects the expression of PRDX6 protein affects cotreatment
/ affects expression
protein 17116298
D008715 81876 RAB1B
RAB1B, member RAS oncogene family [Methionine deficiency co-treated with Homocysteine] affects the expression of RAB1B protein affects cotreatment
/ affects expression
protein 17116298
D008715 9367 RAB9A
RAB9
RAB9A, member RAS oncogene family [Methionine deficiency co-treated with Homocysteine] affects the expression of RAB9A protein affects cotreatment
/ affects expression
protein 17116298
D008715 6519 SLC3A1
ATR1
CSNU1
D2H
NBAT
RBAT
solute carrier family 3 (amino acid transporter heavy chain), member 1 SLC3A1 protein results in increased uptake of Methionine increases uptake
protein 18845132
D008715 6648 SOD2
IPOB
MNSOD
MVCD6
superoxide dismutase 2, mitochondrial (EC:1.15.1.1) Methionine inhibits the reaction [Benzo(a)pyrene results in decreased expression of SOD2 protein] decreases expression
/ decreases reaction
protein 22138271
D008715 6723 SRM
PAPT
SPDSY
SPS1
SRML1
spermidine synthase (EC:2.5.1.16) Methionine inhibits the reaction [Benzo(a)pyrene results in increased expression of SRM protein] decreases reaction
/ increases expression
protein 22138271
D008715 6748 SSR4
TRAPD
signal sequence receptor, delta [Methionine deficiency co-treated with Homocysteine] affects the expression of SSR4 protein affects cotreatment
/ affects expression
protein 17116298
D008715 7411 VBP1
PFD3
PFDN3
VBP-1
von Hippel-Lindau binding protein 1 [Methionine deficiency co-treated with Homocysteine] affects the expression of VBP1 protein affects cotreatment
/ affects expression
protein 17116298
D008715 51699 VPS29
DC15
PEP11
vacuolar protein sorting 29 homolog (S. cerevisiae) (EC:3.1.3.3) [Methionine deficiency co-treated with Homocysteine] affects the expression of VPS29 protein affects cotreatment
/ affects expression
protein 17116298
D008715 7450 VWF
F8VWF
VWD
von Willebrand factor Methionine results in increased degradation of VWF protein increases degradation
protein 15870546

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (2)

OMIM preferred title UniProt
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798

Diseases related to CTD interactions

34 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D001321 D008715 Autistic Disorder marker/mechanism
16917939
19056591
19267885
D006528 D008715 Carcinoma, Hepatocellular therapeutic
2387015
D006332 D008715 Cardiomegaly marker/mechanism
18520950
D002659 D008715 Child Development Disorders, Pervasive marker/mechanism
19267885
D019970 D008715 Cocaine-Related Disorders therapeutic
22438930
D003128 D008715 COMA marker/mechanism
6516898
D003711 D008715 Demyelinating Diseases therapeutic
7527320
D004195 D008715 Disease Models, Animal marker/mechanism
20406136
D056486 D008715 Drug-Induced Liver Injury marker/mechanism
therapeutic
1676404
19236888
20548288
22230336
22330258
D005234 D008715 Fatty Liver marker/mechanism
6987342
17825453
20008134
20196952
20350562
20368703
20697377
23038002
D005235 D008715 Fatty Liver, Alcoholic therapeutic
20118189
D005327 D008715 Fetal Resorption therapeutic
1462254
D005910 D008715 Glioma therapeutic
9061049
D034381 D008715 Hearing Loss therapeutic
17224251
D006501 D008715 Hepatic Encephalopathy marker/mechanism
1155716
D006505 D008715 Hepatitis marker/mechanism
therapeutic
3405528
20368703
D006529 D008715 Hepatomegaly marker/mechanism
2707623
D020138 D008715 HYPERHOMOCYSTEINEMIA marker/mechanism
15870546
15882843
16181111
16213988
16841179
18520950
20406136
D007249 D008715 Inflammation marker/mechanism
20008134
D007669 D008715 Kidney Calculi therapeutic
8112761
D007674 D008715 Kidney Diseases marker/mechanism
20406136
D007859 D008715 Learning Disorders marker/mechanism
15882843
D008103 D008715 Liver Cirrhosis marker/mechanism
17825453
20196952
D008106 D008715 Liver Cirrhosis, Experimental therapeutic
15158331
D008107 D008715 Liver Diseases marker/mechanism
616159
10231861
D008569 D008715 Memory Disorders marker/mechanism
15882843
D008661 D008715 Metabolism, Inborn Errors therapeutic
7527320
C541083 D008715 Non-alcoholic Fatty Liver Disease marker/mechanism
20548288
D020335 D008715 Paraparesis therapeutic
19821069
D011041 D008715 Poisoning therapeutic
1276935
D012559 D008715 Schizophrenia marker/mechanism
15737665
D012640 D008715 Seizures therapeutic
1276935
D016136 D008715 Spina Bifida Occulta therapeutic
8558327
D013118 D008715 Spinal Cord Diseases therapeutic
19821069