| class name | count |
|---|---|
| rosids | 2 |
| class name | count |
|---|---|
| Brassicaceae | 2 |
| Streptomycetaceae | 1 |
| Enterobacteriaceae | 1 |
| br08003 Category | # of metabolite |
|---|
| br08003 Category | KEGG ID | KNApSAcK ID |
|---|
| KNApSAcK ID | name | ChEMBL link | CTD link |
# of proteins in
ChEMBL interaction / related OMIM / related KEGG DISEASE |
# of genes in
CTD interaction / related diseases |
figure |
|---|---|---|---|---|---|---|
|
C00000747
|
L-S-methylcysteine
|
CHEMBL394875
|
1 / 1 / 0 |
|
||
|
C00001379
|
L-Methionine
|
CHEMBL274119
CHEMBL42336 CHEMBL1234268 CHEMBL1770614 CHEMBL2106977 |
D008715
|
2 / 2 / 0 | 24 / 34 |
|
|
C00007594
|
Dihomomethionine
|
|
| accession | description | class description | KNApSAcK metabolite in interactions |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | C00001379 | 2 / 0 |
| P49327 | Fatty acid synthase | Transferase | C00001379 | 0 / 0 |
| P52732 | Kinesin-like protein KIF11 | Other cytosolic protein | C00000747 | 1 / 0 |
| gene | gene name | gene description | KNApSAcK metabolite in interactions |
|---|---|---|---|
| 383 | ARG1 | arginase 1 (EC:3.5.3.1) |
C00001379
|
| 396 | ARHGDIA, GDIA1, NPHS8, RHOGDI, RHOGDI-1 | Rho GDP dissociation inhibitor (GDI) alpha |
C00001379
|
| 635 | BHMT, BHMT1 | betaine--homocysteine S-methyltransferase (EC:2.1.1.5) |
C00001379
|
| 23743 | BHMT2 | betaine--homocysteine S-methyltransferase 2 (EC:2.1.1.10) |
C00001379
|
| 883 | CCBL1, GTK, KAT1, KATI | cysteine conjugate-beta lyase, cytoplasmic (EC:2.6.1.64 2.6.1.7 4.4.1.13) |
C00001379
|
| 1329 | COX5B, COXVB | cytochrome c oxidase subunit Vb (EC:1.9.3.1) |
C00001379
|
| 1398 | CRK, CRKII, p38 | v-crk avian sarcoma virus CT10 oncogene homolog |
C00001379
|
| 1508 | CTSB, APPS, CPSB | cathepsin B (EC:3.4.22.1) |
C00001379
|
| 54512 | EXOSC4, RRP41, RRP41A, Rrp41p, SKI6, Ski6p, hRrp41p, p12A | exosome component 4 |
C00001379
|
| 2739 | GLO1, GLOD1, GLYI | glyoxalase I (EC:4.4.1.5) |
C00001379
|
| 2947 | GSTM3, GST5, GSTB, GSTM3-3, GTM3 | glutathione S-transferase mu 3 (brain) (EC:2.5.1.18) |
C00001379
|
| 9446 | GSTO1, GSTO_1-1, GSTTLp28, P28, SPG-R | glutathione S-transferase omega 1 (EC:2.5.1.18 1.8.5.1 1.20.4.2) |
C00001379
|
| 3176 | HNMT, HMT, HNMT-S1, HNMT-S2 | histamine N-methyltransferase (EC:2.1.1.8) |
C00001379
|
| 5599 | MAPK8, JNK, JNK-46, JNK1, JNK1A2, JNK21B1/2, PRKM8, SAPK1, SAPK1c | mitogen-activated protein kinase 8 (EC:2.7.11.24) |
C00001379
|
| 9588 | PRDX6, 1-Cys, AOP2, NSGPx, PRX, aiPLA2, p29 | peroxiredoxin 6 (EC:1.11.1.9 1.11.1.15) |
C00001379
|
| 81876 | RAB1B | RAB1B, member RAS oncogene family |
C00001379
|
| 9367 | RAB9A, RAB9 | RAB9A, member RAS oncogene family |
C00001379
|
| 6519 | SLC3A1, ATR1, CSNU1, D2H, NBAT, RBAT | solute carrier family 3 (amino acid transporter heavy chain), member 1 |
C00001379
|
| 6648 | SOD2, IPOB, MNSOD, MVCD6 | superoxide dismutase 2, mitochondrial (EC:1.15.1.1) |
C00001379
|
| 6723 | SRM, PAPT, SPDSY, SPS1, SRML1 | spermidine synthase (EC:2.5.1.16) |
C00001379
|
| 6748 | SSR4, TRAPD | signal sequence receptor, delta |
C00001379
|
| 7411 | VBP1, PFD3, PFDN3, VBP-1 | von Hippel-Lindau binding protein 1 |
C00001379
|
| 51699 | VPS29, DC15, PEP11 | vacuolar protein sorting 29 homolog (S. cerevisiae) (EC:3.1.3.3) |
C00001379
|
| 7450 | VWF, F8VWF, VWD | von Willebrand factor |
C00001379
|
| OMIM | preferred title | UniProt |
|---|---|---|
| #152950 | Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation; mclmr |
P52732
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
| MESH or OMIM | name |
KNApSAcK
metabolite |
|---|---|---|
| D001321 | Autistic Disorder |
C00001379
|
| D006528 | Carcinoma, Hepatocellular |
C00001379
|
| D006332 | Cardiomegaly |
C00001379
|
| D002659 | Child Development Disorders, Pervasive |
C00001379
|
| D019970 | Cocaine-Related Disorders |
C00001379
|
| D003128 | COMA |
C00001379
|
| D003711 | Demyelinating Diseases |
C00001379
|
| D004195 | Disease Models, Animal |
C00001379
|
| D056486 | Drug-Induced Liver Injury |
C00001379
|
| D005234 | Fatty Liver |
C00001379
|
| D005235 | Fatty Liver, Alcoholic |
C00001379
|
| D005327 | Fetal Resorption |
C00001379
|
| D005910 | Glioma |
C00001379
|
| D034381 | Hearing Loss |
C00001379
|
| D006501 | Hepatic Encephalopathy |
C00001379
|
| D006505 | Hepatitis |
C00001379
|
| D006529 | Hepatomegaly |
C00001379
|
| D020138 | HYPERHOMOCYSTEINEMIA |
C00001379
|
| D007249 | Inflammation |
C00001379
|
| D007669 | Kidney Calculi |
C00001379
|
| D007674 | Kidney Diseases |
C00001379
|
| D007859 | Learning Disorders |
C00001379
|
| D008103 | Liver Cirrhosis |
C00001379
|
| D008106 | Liver Cirrhosis, Experimental |
C00001379
|
| D008107 | Liver Diseases |
C00001379
|
| D008569 | Memory Disorders |
C00001379
|
| D008661 | Metabolism, Inborn Errors |
C00001379
|
| C541083 | Non-alcoholic Fatty Liver Disease |
C00001379
|
| D020335 | Paraparesis |
C00001379
|
| D011041 | Poisoning |
C00001379
|
| D012559 | Schizophrenia |
C00001379
|
| D012640 | Seizures |
C00001379
|
| D016136 | Spina Bifida Occulta |
C00001379
|
| D013118 | Spinal Cord Diseases |
C00001379
|