PCIDB

KNApSAcK Metabolite C00001391

Metabolite

KNApSAcK Entry

id C00001391
Name Quisqualic acid
CAS RN 52809-07-1
Standard InChI InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)/t2-/m0/s1
Standard InChI (Main Layer) InChI=1S/C5H7N3O5/c6-2(3(9)10)1-8-4(11)7-5(12)13-8/h2H,1,6H2,(H,9,10)(H,7,11,12)

Cluster

Phytochemical cluster
KCF-S cluster No. 6504

Link

ChEMBL

By standard InChI CHEMBL279956
By standard InChI Main Layer CHEMBL279956 CHEMBL168279

KEGG

By LinkDB C08296

CTD

By CAS RN D016318

Species

Summary

Plant class

class name count
rosids 2

Family

family name count
Combretaceae 2

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Quisqualis fructus 3955 Combretaceae rosids Viridiplantae
Quisqualis indica 3956 Combretaceae rosids Viridiplantae

Human Protein / Gene in interaction

31 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P10635 Cytochrome P450 2D6 Cytochrome P450 2D6 CHEMBL279956 CHEMBL1741321 (1)
1 / 0
P49798 Regulator of G-protein signaling 4 Unclassified protein CHEMBL279956 CHEMBL1794499 (1)
2 / 0
P11712 Cytochrome P450 2C9 Cytochrome P450 2C9 CHEMBL279956 CHEMBL1741325 (1)
0 / 1
Q14831 Metabotropic glutamate receptor 7 Metabotropic glutamate receptor CHEMBL279956 CHEMBL712460 (1)
0 / 0
P54132 Bloom syndrome protein Enzyme CHEMBL279956 CHEMBL1614522 (1) CHEMBL1614067 (1)
1 / 2
P00352 Retinal dehydrogenase 1 Enzyme CHEMBL279956 CHEMBL1614458 (1)
0 / 0
Q16665 Hypoxia-inducible factor 1-alpha Transcription Factor CHEMBL168279 CHEMBL1614456 (1) CHEMBL1613803 (1)
0 / 0
Q14416 Metabotropic glutamate receptor 2 Metabotropic glutamate receptor CHEMBL279956 CHEMBL717757 (1) CHEMBL718215 (1)
CHEMBL718222 (1) CHEMBL852485 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL279956 CHEMBL1738610 (1)
0 / 0
O94782 Ubiquitin carboxyl-terminal hydrolase 1 Enzyme CHEMBL279956 CHEMBL1794467 (1)
0 / 0
O15303 Metabotropic glutamate receptor 6 Metabotropic glutamate receptor CHEMBL279956 CHEMBL718130 (1)
1 / 1
P28482 Mitogen-activated protein kinase 1 Erk CHEMBL279956 CHEMBL1613808 (1)
0 / 0
P05177 Cytochrome P450 1A2 Cytochrome P450 1A2 CHEMBL279956 CHEMBL1741322 (1)
0 / 0
Q04609 Glutamate carboxypeptidase 2 M28B CHEMBL279956 CHEMBL888570 (1)
0 / 0
Q14833 Metabotropic glutamate receptor 4 Metabotropic glutamate receptor CHEMBL279956 CHEMBL884506 (1) CHEMBL716502 (1)
CHEMBL714668 (1) CHEMBL852486 (1)
0 / 0
Q13255 Metabotropic glutamate receptor 1 Metabotropic glutamate receptor CHEMBL279956 CHEMBL719076 (1) CHEMBL717335 (1)
CHEMBL851587 (1)
1 / 0
P19838 Nuclear factor NF-kappa-B p105 subunit Transcription Factor CHEMBL279956 CHEMBL1614274 (1) CHEMBL1613823 (1)
0 / 0
P33261 Cytochrome P450 2C19 Cytochrome P450 2C19 CHEMBL279956 CHEMBL168279 CHEMBL1613777 (1) CHEMBL1741323 (1)
1 / 1
P08684 Cytochrome P450 3A4 Cytochrome P450 3A4 CHEMBL279956 CHEMBL1614108 (1) CHEMBL1613886 (1)
CHEMBL1741324 (1)
0 / 1
O75164 Lysine-specific demethylase 4A Enzyme CHEMBL279956 CHEMBL1737991 (1)
0 / 0
P27695 DNA-(apurinic or apyrimidinic site) lyase Enzyme CHEMBL279956 CHEMBL1614211 (1)
0 / 0
Q99549 M-phase phosphoprotein 8 Unclassified protein CHEMBL279956 CHEMBL1738402 (1)
0 / 0
Q9UPY5 Cystine/glutamate transporter Unclassified protein CHEMBL279956 CHEMBL1107232 (1)
0 / 0
Q14832 Metabotropic glutamate receptor 3 Metabotropic glutamate receptor CHEMBL279956 CHEMBL717238 (1)
0 / 0
P41594 Metabotropic glutamate receptor 5 Metabotropic glutamate receptor CHEMBL279956 CHEMBL711712 (1) CHEMBL715723 (1)
0 / 0
Q9UBT6 DNA polymerase kappa Enzyme CHEMBL279956 CHEMBL1794536 (1)
0 / 0
B2RXH2 Lysine-specific demethylase 4E Enzyme CHEMBL279956 CHEMBL1613914 (2)
0 / 0
Q96KQ7 Histone-lysine N-methyltransferase EHMT2 Enzyme CHEMBL279956 CHEMBL1738442 (2)
0 / 0
Q9NUW8 Tyrosyl-DNA phosphodiesterase 1 Enzyme CHEMBL279956 CHEMBL1614364 (1)
1 / 1
O00255 Menin Unclassified protein CHEMBL279956 CHEMBL1614531 (1)
2 / 5
Q03164 Histone-lysine N-methyltransferase 2A Enzyme CHEMBL279956 CHEMBL1614531 (1)
1 / 3

CTD interaction (1)

compound gene gene name gene description interaction interaction type form reference
pmid
D016318 2915 GRM5
GPRC1E
MGLUR5
mGlu5
glutamate receptor, metabotropic 5 [3-cyano-N-(1,3-diphenyl-1H-pyrazol-5-yl)benzamide binds to GRM5 protein] promotes the reaction [Quisqualic Acid binds to and results in increased activity of GRM5 protein] affects binding
/ increases activity
/ increases reaction
protein 15608073

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (11)

OMIM preferred title UniProt
#210900 Bloom syndrome; blm P54132
#609535 Drug metabolism, poor, cyp2c19-related P33261
#608902 Drug metabolism, poor, cyp2d6-related P10635
#605130 Hairy elbows, short stature, facial dysmorphism, and developmental delay Q03164
#145000 Hyperparathyroidism 1; hrpt1 O00255
#131100 Multiple endocrine neoplasia, type i; men1 O00255
#257270 Night blindness, congenital stationary, type 1b; csnb1b O15303
#604906 Schizophrenia 9; sczd9 P49798
#181500 Schizophrenia; sczd P49798
#614831 Spinocerebellar ataxia, autosomal recessive 13; scar13 Q13255
#607250 Spinocerebellar ataxia, autosomal recessive, with axonal neuropathy; scan1 Q9NUW8

KEGG DISEASE (14)

KEGG disease name UniProt
H00033 Adrenal carcinoma O00255 (related)
H00034 Carcinoid O00255 (related)
H00045 Malignant islet cell carcinoma O00255 (related)
H00246 Primary hyperparathyroidism O00255 (related)
H01102 Pituitary adenomas O00255 (related)
H00787 Congenital stationary night blindness (CSNB) O15303 (related)
H00036 Osteosarcoma P08684 (marker)
H01205 Coumarin resistance P11712 (related)
H01171 Poor drug metabolism (PM) P33261 (related)
H00094 DNA repair defects P54132 (related)
H00296 Defects in RecQ helicases P54132 (related)
H00001 Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) Q03164 (related)
Q03164 (marker)
H00002 Acute lymphoblastic leukemia (ALL) (precursor T lymphoblastic leukemia) Q03164 (related)
H00063 Spinocerebellar ataxia (SCA) Q9NUW8 (related)

Diseases related to CTD interactions

3 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D004827 D016318 Epilepsy marker/mechanism
7705426
D009410 D016318 Nerve Degeneration marker/mechanism
3526175
D012640 D016318 Seizures marker/mechanism
1970362
2853076
7574061