PCIDB

KNApSAcK Metabolite C00001426

Metabolite

KNApSAcK Entry

id C00001426
Name Phenethylamine
CAS RN 64-04-0
Standard InChI InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2
Standard InChI (Main Layer) InChI=1S/C8H11N/c9-7-6-8-4-2-1-3-5-8/h1-5H,6-7,9H2

Cluster

Phytochemical cluster
KCF-S cluster No. 885

Link

ChEMBL

By standard InChI CHEMBL610
By standard InChI Main Layer CHEMBL610

KEGG

By LinkDB C05332

CTD

By CAS RN C029261

Human Protein / Gene in interaction

8 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q16637 Survival motor neuron protein Unclassified protein CHEMBL610 CHEMBL1613842 (1)
4 / 2
P08183 Multidrug resistance protein 1 drug CHEMBL610 CHEMBL2076046 (1)
1 / 0
P11509 Cytochrome P450 2A6 Cytochrome P450 2A6 CHEMBL610 CHEMBL832816 (1)
0 / 0
P83916 Chromobox protein homolog 1 Unclassified protein CHEMBL610 CHEMBL1794401 (1)
0 / 0
Q16853 Membrane primary amine oxidase Enzyme CHEMBL610 CHEMBL853855 (1) CHEMBL855013 (1)
0 / 0
P28223 5-hydroxytryptamine receptor 2A Serotonin receptor CHEMBL610 CHEMBL617344 (1) CHEMBL994216 (1)
0 / 0
Q96RJ0 Trace amine-associated receptor 1 Trace amine receptor CHEMBL610 CHEMBL989986 (1) CHEMBL989987 (1)
CHEMBL1930658 (1)
0 / 0
P07477 Trypsin-1 S1A CHEMBL610 CHEMBL821445 (1)
1 / 1

CTD interaction (10)

compound gene gene name gene description interaction interaction type form reference
pmid
C029261 4129 MAOB
monoamine oxidase B (EC:1.4.3.4) Phenylpropanolamine inhibits the reaction [MAOB protein results in increased degradation of phenethylamine] decreases reaction
/ increases degradation
protein 3961266
C029261 6570 SLC18A1
CGAT
VAT1
VMAT1
solute carrier family 18 (vesicular monoamine transporter), member 1 phenethylamine inhibits the reaction [SLC18A1 protein results in increased uptake of Serotonin] decreases reaction
/ increases uptake
protein 8245983
C029261 6530 SLC6A2
NAT1
NET
NET1
SLC6A5
solute carrier family 6 (neurotransmitter transporter), member 2 SLC6A2 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
C029261 6531 SLC6A3
DAT
DAT1
PKDYS
solute carrier family 6 (neurotransmitter transporter), member 3 Cocaine inhibits the reaction [SLC6A3 protein results in increased transport of phenethylamine] decreases reaction
/ increases transport
protein 15764732
C029261 6531 SLC6A3
DAT
DAT1
PKDYS
solute carrier family 6 (neurotransmitter transporter), member 3 SLC6A3 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
C029261 6531 SLC6A3
DAT
DAT1
PKDYS
solute carrier family 6 (neurotransmitter transporter), member 3 SLC6A3 protein results in increased transport of phenethylamine increases transport
protein 15764732
C029261 6532 SLC6A4
5-HTT
5-HTTLPR
5HTT
HTT
OCD1
SERT
SERT1
hSERT
solute carrier family 6 (neurotransmitter transporter), member 4 SLC6A4 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
C029261 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 SLC6A2 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
C029261 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 SLC6A3 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900
C029261 134864 TAAR1
RP11-295F4.9
TA1
TAR1
TRAR1
trace amine associated receptor 1 SLC6A4 protein promotes the reaction [phenethylamine results in increased activity of TAAR1 protein] increases activity
/ increases reaction
protein 17234900

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (6)

OMIM preferred title UniProt
#612244 Inflammatory bowel disease 13; ibd13 P08183
#167800 Pancreatitis, hereditary; pctt P07477
#253300 Spinal muscular atrophy, type i; sma1 Q16637
#253550 Spinal muscular atrophy, type ii; sma2 Q16637
#253400 Spinal muscular atrophy, type iii; sma3 Q16637
#271150 Spinal muscular atrophy, type iv; sma4 Q16637

KEGG DISEASE (2)

KEGG disease name UniProt
H00933 Hereditary pancreatitis P07477 (related)
H00455 Spinal muscular atrophy (SMA) Q16637 (related)
Q16637 (related)

Diseases related to CTD interactions

5 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D002375 C029261 Catalepsy therapeutic
6119681
D004409 C029261 Dyskinesia, Drug-Induced marker/mechanism
28790
D006948 C029261 Hyperkinesis marker/mechanism
28790
D015878 C029261 Mydriasis marker/mechanism
648586
D019954 C029261 Neurobehavioral Manifestations marker/mechanism
648586