KCF-S cluster No. 885 (10 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (10)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	32
asterids	13
eudicotyledons	8
Spermatophyta	2
Liliopsida	1
Magnoliophyta	1
Embryophyta	1

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Cumulative family count (Top 20)

class name	count
Rutaceae	18
Brassicaceae	7
Asteraceae	4
Fabaceae	4
Solanaceae	4
Apiaceae	3
Crassulaceae	2
Rosaceae	2
Pseudomonadaceae	2
Musaceae	1
Pinaceae	1
Pyralidae	1
Piperaceae	1
Salicaceae	1
Viscaceae	1
Montiaceae	1
Gymnomitriaceae	1
Ganodermataceae	1
Caryophyllaceae	1
Petiveriaceae	1

KEGG BRITE br08003

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Categories (0)

br08003 Category	# of metabolite

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metabolites link (0)

br08003 Category	KEGG ID	KNApSAcK ID

Metabolite list (10)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001426	Phenethylamine	CHEMBL610	C029261	8 / 6 / 2	6 / 5
C00002663	2-Phenylethanol / Phenethyl alcohol / Phenylethyl alcohol / beta-Phenethyl alcohol	CHEMBL448500	D010626	2 / 1 / 1
C00007535	Phenylacetaldehyde / Benzeneacetaldehyde / Phenylacetic aldehyde		C013192		3 / 0
C00007674	Phenylacetonitrile
C00029809	Benzenepropanenitrile
C00029811	Benzyl alcohol / (Hydroxymethyl)benzene	CHEMBL720	D019905	94 / 41 / 36	1 / 6
C00035115	Benzenepropanol / 3-Phenylpropanol / Hydrocinnamic alcohol	CHEMBL1606391	C016655	3 / 1 / 4
C00042776	N-Methyl-beta-phenethylamine	CHEMBL45763	C027141	2 / 1 / 4
C00043309	Benzylamine	CHEMBL522	C030796	8 / 3 / 2
C00048326	Benzene acetonitrile

Human Protein / Gene in interactions

110 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P21397	Amine oxidase [flavin-containing] A	Oxidoreductase	C00029811 C00043309	1 / 1
P07477	Trypsin-1	S1A	C00001426 C00043309	1 / 1
Q96RJ0	Trace amine-associated receptor 1	Trace amine receptor	C00001426 C00042776	0 / 0
P28223	5-hydroxytryptamine receptor 2A	Serotonin receptor	C00001426 C00029811	0 / 0
Q16853	Membrane primary amine oxidase	Enzyme	C00001426 C00043309	0 / 0
P11509	Cytochrome P450 2A6	Cytochrome P450 2A6	C00001426 C00029811	0 / 0
P08183	Multidrug resistance protein 1	drug	C00001426 C00043309	1 / 0
P22303	Acetylcholinesterase	Hydrolase	C00029811	1 / 0
P49146	Neuropeptide Y receptor type 2	Neuropeptide Y receptor	C00029811	0 / 0
P29466	Caspase-1	C14	C00029811	0 / 0
P17252	Protein kinase C alpha type	Alpha	C00029811	0 / 0
P27361	Mitogen-activated protein kinase 3	Erk	C00029811	0 / 0
P14780	Matrix metalloproteinase-9	M10A	C00029811	2 / 2
Q13315	Serine-protein kinase ATM	Atypical serine/threonine protein kinase PIKK subfamily	C00042776	1 / 4
P16473	Thyrotropin receptor	Glycohormone receptor	C00029811	3 / 2
P42574	Caspase-3	C14	C00043309	0 / 0
P00918	Carbonic anhydrase 2	Lyase	C00029811	1 / 2
P07550	Beta-2 adrenergic receptor	Adrenergic receptor	C00029811	0 / 1
P10635	Cytochrome P450 2D6	Cytochrome P450 2D6	C00029811	1 / 0
P25021	Histamine H2 receptor	Histamine receptor	C00029811	0 / 0
P35367	Histamine H1 receptor	Histamine receptor	C00029811	0 / 0
Q01959	Sodium-dependent dopamine transporter	Dopamine	C00029811	1 / 0
P08912	Muscarinic acetylcholine receptor M5	Acetylcholine receptor	C00029811	0 / 0
P18825	Alpha-2C adrenergic receptor	Adrenergic receptor	C00029811	0 / 0
P13945	Beta-3 adrenergic receptor	Adrenergic receptor	C00029811	0 / 0
P33765	Adenosine receptor A3	Adenosine receptor	C00029811	0 / 0
P25024	C-X-C chemokine receptor type 1	CXC chemokine receptor	C00029811	0 / 0
P06241	Tyrosine-protein kinase Fyn	Src	C00029811	0 / 0
Q08209	Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform	Ser_Thr	C00029811	0 / 0
P11712	Cytochrome P450 2C9	Cytochrome P450 2C9	C00029811	0 / 1
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00029811	1 / 8
P11473	Vitamin D3 receptor	NR1I1	C00029811	2 / 3
P14416	D(2) dopamine receptor	Dopamine receptor	C00029811	2 / 0
P23219	Prostaglandin G/H synthase 1	Oxidoreductase	C00029811	0 / 0
P37288	Vasopressin V1a receptor	Vasopressin and oxytocin receptor	C00029811	0 / 0
P41145	Kappa-type opioid receptor	Opioid receptor	C00029811	0 / 0
Q9Y271	Cysteinyl leukotriene receptor 1	Leukotriene receptor	C00029811	0 / 0
P29274	Adenosine receptor A2a	Adenosine receptor	C00029811	0 / 0
P25929	Neuropeptide Y receptor type 1	Neuropeptide Y receptor	C00029811	0 / 0
P19801	Amiloride-sensitive amine oxidase [copper-containing]	Enzyme	C00043309	0 / 0
P50052	Type-2 angiotensin II receptor	Angiotensin receptor	C00029811	1 / 1
P17948	Vascular endothelial growth factor receptor 1	Vegfr	C00029811	0 / 0
P41968	Melanocortin receptor 3	Melanocortin receptor	C00029811	1 / 0
P08246	Neutrophil elastase	S1A	C00029811	2 / 1
O75496	Geminin	Unclassified protein	C00002663	0 / 0
O60656	UDP-glucuronosyltransferase 1-9	Enzyme	C00029811	0 / 0
P04035	3-hydroxy-3-methylglutaryl-coenzyme A reductase	Oxidoreductase	C00029811	0 / 0
P08913	Alpha-2A adrenergic receptor	Adrenergic receptor	C00029811	0 / 0
P21917	D(4) dopamine receptor	Dopamine receptor	C00029811	0 / 0
P30988	Calcitonin receptor	Calcitonin receptor	C00029811	0 / 0
P35462	D(3) dopamine receptor	Dopamine receptor	C00029811	1 / 0
P41143	Delta-type opioid receptor	Opioid receptor	C00029811	0 / 0
Q92731	Estrogen receptor beta	NR3A2	C00029811	0 / 1
P41595	5-hydroxytryptamine receptor 2B	Serotonin receptor	C00029811	0 / 0
P25101	Endothelin-1 receptor	Endothelin receptor	C00029811	0 / 0
P30411	B2 bradykinin receptor	Bradykinin receptor	C00029811	0 / 0
P32245	Melanocortin receptor 4	Melanocortin receptor	C00029811	1 / 0
P32238	Cholecystokinin receptor type A	Cholecystokinin receptor	C00029811	0 / 0
P08311	Cathepsin G	S1A	C00029811	0 / 0
Q99720	Sigma non-opioid intracellular receptor 1	Membrane receptor	C00029811	1 / 0
P03956	Interstitial collagenase	M10A	C00029811	0 / 1
P32241	Vasoactive intestinal polypeptide receptor 1	Vasoactive intestinal peptide receptor	C00029811	0 / 0
P83916	Chromobox protein homolog 1	Unclassified protein	C00001426	0 / 0
P04150	Glucocorticoid receptor	NR3C1	C00029811	0 / 1
P08172	Muscarinic acetylcholine receptor M2	Acetylcholine receptor	C00029811	2 / 0
P11229	Muscarinic acetylcholine receptor M1	Acetylcholine receptor	C00029811	0 / 0
P21554	Cannabinoid receptor 1	Cannabinoid receptor	C00029811	0 / 0
P31645	Sodium-dependent serotonin transporter	Serotonin	C00029811	2 / 0
P04626	Receptor tyrosine-protein kinase erbB-2	TK tyrosine-protein kinase EGFR subfamily	C00029811	5 / 9
P20309	Muscarinic acetylcholine receptor M3	Acetylcholine receptor	C00029811	1 / 0
P21452	Substance-K receptor	Neurokinin receptor	C00029811	0 / 0
P51679	C-C chemokine receptor type 4	CC chemokine receptor	C00029811	0 / 0
P51681	C-C chemokine receptor type 5	CC chemokine receptor	C00029811	3 / 0
P50406	5-hydroxytryptamine receptor 6	Serotonin receptor	C00029811	0 / 0
P41597	C-C chemokine receptor type 2	CC chemokine receptor	C00029811	1 / 0
P28482	Mitogen-activated protein kinase 1	Erk	C00029811	0 / 0
P08575	Receptor-type tyrosine-protein phosphatase C	Enzyme	C00029811	2 / 1
P05177	Cytochrome P450 1A2	Cytochrome P450 1A2	C00029811	0 / 0
Q12809	Potassium voltage-gated channel subfamily H member 2	KCNH, Kv10-12.x (Ether-a-go-go)	C00029811	2 / 2
O76074	cGMP-specific 3',5'-cyclic phosphodiesterase	PDE_5A	C00029811	0 / 0
P03372	Estrogen receptor	NR3A1	C00029811	1 / 1
P08588	Beta-1 adrenergic receptor	Adrenergic receptor	C00029811	1 / 0
Q16539	Mitogen-activated protein kinase 14	p38	C00029811	0 / 0
P35354	Prostaglandin G/H synthase 2	Oxidoreductase	C00029811	0 / 3
P28335	5-hydroxytryptamine receptor 2C	Serotonin receptor	C00029811	0 / 0
P35372	Mu-type opioid receptor	Opioid receptor	C00029811	0 / 0
P08173	Muscarinic acetylcholine receptor M4	Acetylcholine receptor	C00029811	0 / 0
P25103	Substance-P receptor	Neurokinin receptor	C00029811	0 / 0
P25105	Platelet-activating factor receptor	PAF receptor	C00029811	0 / 0
P33032	Melanocortin receptor 5	Melanocortin receptor	C00029811	0 / 0
P55210	Caspase-7	C14	C00043309	0 / 0
P33261	Cytochrome P450 2C19	Cytochrome P450 2C19	C00029811	1 / 1
P08684	Cytochrome P450 3A4	Cytochrome P450 3A4	C00029811	0 / 1
P05181	Cytochrome P450 2E1	Cytochrome P450 2E1	C00029811	0 / 0
P21728	D(1A) dopamine receptor	Dopamine receptor	C00029811	0 / 0
P19224	UDP-glucuronosyltransferase 1-6	Enzyme	C00029811	0 / 0
Q16236	Nuclear factor erythroid 2-related factor 2	Unclassified protein	C00029811	0 / 0
Q16637	Survival motor neuron protein	Unclassified protein	C00001426	4 / 1
P23975	Sodium-dependent noradrenaline transporter	Norepinephrine	C00029811	1 / 1
P25100	Alpha-1D adrenergic receptor	Adrenergic receptor	C00029811	0 / 0
P30542	Adenosine receptor A1	Adenosine receptor	C00029811	0 / 0
P18089	Alpha-2B adrenergic receptor	Adrenergic receptor	C00029811	0 / 0
P24557	Thromboxane-A synthase	Cytochrome P450 5A1	C00029811	1 / 1
P06239	Tyrosine-protein kinase Lck	Src	C00029811	0 / 1
P25025	C-X-C chemokine receptor type 2	CXC chemokine receptor	C00029811	0 / 0
P11086	Phenylethanolamine N-methyltransferase	Enzyme	C00043309	0 / 0
Q9UBT6	DNA polymerase kappa	Enzyme	C00035115	0 / 0
Q9NUW8	Tyrosyl-DNA phosphodiesterase 1	Enzyme	C00002663	1 / 1
Q13951	Core-binding factor subunit beta	Unclassified protein	C00035115	0 / 1
Q01196	Runt-related transcription factor 1	Unclassified protein	C00035115	1 / 4

10 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1646	AKR1C2, AKR1C-pseudo, BABP, DD, DD2, DDH2, HAKRD, HBAB, MCDR2, SRXY8	aldo-keto reductase family 1, member C2 (EC:1.3.1.20 1.1.1.357)	C00007535
3576	IL8, CXCL8, GCP-1, GCP1, LECT, LUCT, LYNAP, MDNCF, MONAP, NAF, NAP-1, NAP1	interleukin 8	C00007535
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00007535
4129	MAOB	monoamine oxidase B (EC:1.4.3.4)	C00001426
6570	SLC18A1, CGAT, VAT1, VMAT1	solute carrier family 18 (vesicular monoamine transporter), member 1	C00001426
6530	SLC6A2, NAT1, NET, NET1, SLC6A5	solute carrier family 6 (neurotransmitter transporter), member 2	C00001426
6531	SLC6A3, DAT, DAT1, PKDYS	solute carrier family 6 (neurotransmitter transporter), member 3	C00001426
6532	SLC6A4, 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT	solute carrier family 6 (neurotransmitter transporter), member 4	C00001426
134864	TAAR1, RP11-295F4.9, TA1, TAR1, TRAR1	trace amine associated receptor 1	C00001426
231	AKR1B1, ADR, ALDR1, ALR2, AR	aldo-keto reductase family 1, member B1 (aldose reductase) (EC:1.1.1.21)	C00029811

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions