PCIDB

KNApSAcK Metabolite C00001430

Metabolite

KNApSAcK Entry

id C00001430
Name Skatole
CAS RN 83-34-1
Standard InChI InChI=1S/C9H9N/c1-7-6-10-9-5-3-2-4-8(7)9/h2-6,10H,1H3
Standard InChI (Main Layer) InChI=1S/C9H9N/c1-7-6-10-9-5-3-2-4-8(7)9/h2-6,10H,1H3

Cluster

Phytochemical cluster No. 4
KCF-S cluster No. 710

Link

ChEMBL

By standard InChI CHEMBL1329793
By standard InChI Main Layer CHEMBL1329793

KEGG

By LinkDB C08313

CTD

By CAS RN D012862

Human Protein / Gene in interaction

2 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
Q13315 Serine-protein kinase ATM Atypical serine/threonine protein kinase PIKK subfamily CHEMBL1329793 CHEMBL1614153 (1)
1 / 4
O75496 Geminin Unclassified protein CHEMBL1329793 CHEMBL2114780 (1)
0 / 0

CTD interaction (26)

compound gene gene name gene description interaction interaction type form reference
pmid
D012862 196 AHR
bHLHe76
aryl hydrocarbon receptor [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Skatole results in increased expression of CYP1A1 mRNA] affects binding
/ decreases activity
/ decreases reaction
/ increases expression
protein 20187624
D012862 196 AHR
bHLHe76
aryl hydrocarbon receptor [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Skatole results in increased expression of CYP2F1 mRNA] affects binding
/ decreases activity
/ decreases reaction
/ increases expression
protein 20187624
D012862 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) 1-aminobenzotriazole inhibits the reaction [Skatole results in increased expression of CYP1A1 mRNA] decreases reaction
/ increases expression
mRNA 20187624
D012862 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Skatole results in increased expression of CYP1A1 mRNA] affects binding
/ decreases activity
/ decreases reaction
/ increases expression
mRNA 20187624
D012862 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Cycloheximide promotes the reaction [Skatole results in increased expression of CYP1A1 mRNA] increases expression
/ increases reaction
mRNA 20187624
D012862 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) CYP1A1 protein results in increased metabolism of and results in increased activity of Skatole increases activity
/ increases metabolic processing
protein 20795680
D012862 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) CYP1A1 protein results in increased metabolism of Skatole increases metabolic processing
protein 20187624
D012862 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) [CYP1A1 protein results in increased metabolism of Skatole] which results in increased chemical synthesis of 3-methyleneindolenine increases chemical synthesis
/ increases metabolic processing
protein 20187624
D012862 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Dactinomycin inhibits the reaction [Skatole results in increased expression of CYP1A1 mRNA] decreases reaction
/ increases expression
mRNA 20187624
D012862 1543 CYP1A1
AHH
AHRR
CP11
CYP1
P1-450
P450-C
P450DX
cytochrome P450, family 1, subfamily A, polypeptide 1 (EC:1.14.14.1) Skatole metabolite results in increased expression of CYP1A1 mRNA increases expression
mRNA 20187624
D012862 1553 CYP2A13
CPAD
CYP2A
CYPIIA13
cytochrome P450, family 2, subfamily A, polypeptide 13 (EC:1.14.14.1) CYP2A13 protein results in increased metabolism of and results in increased activity of Skatole increases activity
/ increases metabolic processing
protein 20795680
D012862 1553 CYP2A13
CPAD
CYP2A
CYPIIA13
cytochrome P450, family 2, subfamily A, polypeptide 13 (EC:1.14.14.1) CYP2A13 protein results in increased metabolism of Skatole increases metabolic processing
protein 20187624
D012862 1553 CYP2A13
CPAD
CYP2A
CYPIIA13
cytochrome P450, family 2, subfamily A, polypeptide 13 (EC:1.14.14.1) [CYP2A13 protein results in increased metabolism of Skatole] which results in increased chemical synthesis of 3-methyleneindolenine increases chemical synthesis
/ increases metabolic processing
protein 20187624
D012862 1553 CYP2A13
CPAD
CYP2A
CYPIIA13
cytochrome P450, family 2, subfamily A, polypeptide 13 (EC:1.14.14.1) [Methoxsalen results in decreased activity of CYP2A13 protein] which results in decreased susceptibility to Skatole decreases activity
/ decreases response to substance
protein 20795680
D012862 1572 CYP2F1
C2F1
CYP2F
cytochrome P450, family 2, subfamily F, polypeptide 1 (EC:1.14.14.1) 1-aminobenzotriazole inhibits the reaction [Skatole results in increased expression of CYP2F1 mRNA] decreases reaction
/ increases expression
mRNA 20187624
D012862 1572 CYP2F1
C2F1
CYP2F
cytochrome P450, family 2, subfamily F, polypeptide 1 (EC:1.14.14.1) [alpha-naphthoflavone binds to and results in decreased activity of AHR protein] inhibits the reaction [Skatole results in increased expression of CYP2F1 mRNA] affects binding
/ decreases activity
/ decreases reaction
/ increases expression
mRNA 20187624
D012862 1572 CYP2F1
C2F1
CYP2F
cytochrome P450, family 2, subfamily F, polypeptide 1 (EC:1.14.14.1) Cycloheximide inhibits the reaction [Skatole results in increased expression of CYP2F1 mRNA] decreases reaction
/ increases expression
mRNA 20187624
D012862 1572 CYP2F1
C2F1
CYP2F
cytochrome P450, family 2, subfamily F, polypeptide 1 (EC:1.14.14.1) CYP2F1 protein results in increased metabolism of and results in increased activity of Skatole increases activity
/ increases metabolic processing
protein 20795680
D012862 1572 CYP2F1
C2F1
CYP2F
cytochrome P450, family 2, subfamily F, polypeptide 1 (EC:1.14.14.1) CYP2F1 protein results in increased metabolism of Skatole increases metabolic processing
protein 20187624
D012862 1572 CYP2F1
C2F1
CYP2F
cytochrome P450, family 2, subfamily F, polypeptide 1 (EC:1.14.14.1) [CYP2F1 protein results in increased metabolism of Skatole] which results in increased chemical synthesis of 3-methyleneindolenine increases chemical synthesis
/ increases metabolic processing
protein 20187624
D012862 1572 CYP2F1
C2F1
CYP2F
cytochrome P450, family 2, subfamily F, polypeptide 1 (EC:1.14.14.1) Dactinomycin inhibits the reaction [Skatole results in increased expression of CYP2F1 mRNA] decreases reaction
/ increases expression
mRNA 20187624
D012862 1572 CYP2F1
C2F1
CYP2F
cytochrome P450, family 2, subfamily F, polypeptide 1 (EC:1.14.14.1) Skatole metabolite results in increased expression of CYP2F1 mRNA increases expression
mRNA 20187624
D012862 1580 CYP4B1
CYPIVB1
P-450HP
cytochrome P450, family 4, subfamily B, polypeptide 1 (EC:1.14.14.1) CYP4B1 protein results in increased metabolism of Skatole increases metabolic processing
protein 20187624
D012862 1580 CYP4B1
CYPIVB1
P-450HP
cytochrome P450, family 4, subfamily B, polypeptide 1 (EC:1.14.14.1) [CYP4B1 protein results in increased metabolism of Skatole] which results in increased chemical synthesis of 3-methyleneindolenine increases chemical synthesis
/ increases metabolic processing
protein 20187624
D012862 142 PARP1
ADPRT
ADPRT_1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) Skatole results in increased cleavage of PARP1 protein increases cleavage
protein 19700606
D012862 7157 TP53
BCC7
LFS1
P53
TRP53
tumor protein p53 Skatole results in increased phosphorylation of and affects the localization of TP53 protein affects localization
/ increases phosphorylation
protein 19700606

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (1)

OMIM preferred title UniProt
#208900 Ataxia-telangiectasia; at Q13315

KEGG DISEASE (4)

KEGG disease name UniProt
H00005 Chronic lymphocytic leukemia (CLL) Q13315 (related)
H00064 Ataxia telangiectasia (AT) Q13315 (related)
H00094 DNA repair defects Q13315 (related)
H00848 Ataxia with ocular apraxia (AOA) Q13315 (related)

Diseases related to CTD interactions

1 disease from interactions of metabolites

MeSH disease OMIM compound disease name evidence type reference
pmid
D055370 D012862 Lung Injury marker/mechanism
20795680