KNApSAcK Metabolite C00001491
Metabolite
KNApSAcK Entry
| id | C00001491 |
|---|---|
| Name | ATP / Adenosine triphosphate |
| CAS RN | 56-65-5 |
| Standard InChI | InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20)/t4-,6+,7?,10-/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C10H16N5O13P3/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(26-10)1-25-30(21,22)28-31(23,24)27-29(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H2,11,12,13)(H2,18,19,20) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 2262 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer | CHEMBL14249 |
KEGG
| By LinkDB | C00002 |
|---|
CTD
| By CAS RN | D000255 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Enterobacteriaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Escherichia coli | 562 | Enterobacteriaceae | Bacteria |
Human Protein / Gene in interaction
32 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| Q15172 | Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform | Protein phosphatase regulatory subunit | CHEMBL14249 |
CHEMBL764181
(1)
|
0 / 0 |
| P47900 | P2Y purinoceptor 1 | Purine receptor | CHEMBL14249 |
CHEMBL750155
(1)
CHEMBL1067693
(1)
CHEMBL1806219 (1) |
0 / 0 |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | CHEMBL14249 |
CHEMBL1614063
(1)
|
0 / 0 |
| O14757 | Serine/threonine-protein kinase Chk1 | Chk1 | CHEMBL14249 |
CHEMBL1273371
(1)
|
0 / 0 |
| O14965 | Aurora kinase A | Aur | CHEMBL14249 |
CHEMBL933055
(1)
CHEMBL931970
(1)
|
0 / 0 |
| P02545 | Prelamin-A/C | Unclassified protein | CHEMBL14249 |
CHEMBL1614544
(1)
|
11 / 10 |
| P00519 | Tyrosine-protein kinase ABL1 | Abl | CHEMBL14249 |
CHEMBL1249660
(1)
|
1 / 4 |
| Q15077 | P2Y purinoceptor 6 | Purine receptor | CHEMBL14249 |
CHEMBL757045
(1)
CHEMBL917106
(1)
|
0 / 0 |
| P04183 | Thymidine kinase, cytosolic | Enzyme | CHEMBL14249 |
CHEMBL811608
(1)
|
0 / 1 |
| P51582 | P2Y purinoceptor 4 | Purine receptor | CHEMBL14249 |
CHEMBL756885
(1)
CHEMBL757039
(1)
CHEMBL917104 (2) CHEMBL1629159 (1) |
0 / 0 |
| P56373 | P2X purinoceptor 3 | NS | CHEMBL14249 |
CHEMBL751806
(1)
|
0 / 0 |
| P00533 | Epidermal growth factor receptor | TK tyrosine-protein kinase EGFR subfamily | CHEMBL14249 |
CHEMBL1273366
(1)
|
1 / 11 |
| Q99571 | P2X purinoceptor 4 | NS | CHEMBL14249 |
CHEMBL750982
(1)
CHEMBL2184479
(1)
|
0 / 0 |
| P31751 | RAC-beta serine/threonine-protein kinase | Akt | CHEMBL14249 |
CHEMBL1273368
(1)
|
2 / 2 |
| Q96G91 | P2Y purinoceptor 11 | Purine receptor | CHEMBL14249 |
CHEMBL759351
(1)
CHEMBL755047
(1)
CHEMBL1806221 (1) |
0 / 0 |
| P27708 | CAD protein | Enzyme | CHEMBL14249 |
CHEMBL653966
(1)
|
0 / 0 |
| P41231 | P2Y purinoceptor 2 | Purine receptor | CHEMBL14249 |
CHEMBL751765
(1)
CHEMBL753284
(1)
CHEMBL917101 (1) CHEMBL971536 (1) CHEMBL971539 (1) CHEMBL971541 (1) CHEMBL974435 (1) CHEMBL974440 (1) CHEMBL971431 (1) |
0 / 0 |
| P43220 | Glucagon-like peptide 1 receptor | Glucagon-like peptide receptor | CHEMBL14249 |
CHEMBL2114931
(1)
|
0 / 0 |
| P32189 | Glycerol kinase | Enzyme | CHEMBL14249 |
CHEMBL684721
(1)
|
1 / 1 |
| P08107 | Heat shock 70 kDa protein 1A/1B | Unclassified protein | CHEMBL14249 |
CHEMBL1614297
(1)
|
0 / 0 |
| Q9H244 | P2Y purinoceptor 12 | Purine receptor | CHEMBL14249 |
CHEMBL931131
(1)
|
1 / 1 |
| Q96GD4 | Aurora kinase B | Aur | CHEMBL14249 |
CHEMBL1273369
(1)
|
0 / 0 |
| P49137 | MAP kinase-activated protein kinase 2 | CAMK serine/threonine protein kinase MAPKAPK | CHEMBL14249 |
CHEMBL1071871
(1)
CHEMBL1071872
(1)
CHEMBL1071873 (1) |
0 / 0 |
| Q9BXA7 | Testis-specific serine/threonine-protein kinase 1 | Tssk | CHEMBL14249 |
CHEMBL1027665
(1)
|
0 / 0 |
| Q99572 | P2X purinoceptor 7 | NS | CHEMBL14249 |
CHEMBL754454
(1)
|
0 / 0 |
| P51575 | P2X purinoceptor 1 | NS | CHEMBL14249 |
CHEMBL759509
(1)
|
0 / 0 |
| P11142 | Heat shock cognate 71 kDa protein | Unclassified protein | CHEMBL14249 |
CHEMBL1614143
(1)
|
0 / 0 |
| P24864 | G1/S-specific cyclin-E1 | Other cytosolic protein | CHEMBL14249 |
CHEMBL1273370
(1)
|
0 / 2 |
| P24941 | Cyclin-dependent kinase 2 | Cdc2 | CHEMBL14249 |
CHEMBL1273370
(1)
|
0 / 0 |
| O96020 | G1/S-specific cyclin-E2 | Other cytosolic protein | CHEMBL14249 |
CHEMBL1273370
(1)
|
0 / 2 |
| P07900 | Heat shock protein HSP 90-alpha | Other cytosolic protein | CHEMBL14249 |
CHEMBL867907
(1)
|
0 / 0 |
| P08238 | Heat shock protein HSP 90-beta | Other cytosolic protein | CHEMBL14249 |
CHEMBL867907
(1)
|
0 / 0 |
CTD interaction (168)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D000255 | 10351 |
ABCA8
|
ATP-binding cassette, sub-family A (ABC1), member 8 | Adenosine Triphosphate affects the reaction [ABCA8 protein results in increased uptake of estradiol-17 beta-glucuronide] |
affects reaction
/ increases uptake |
protein |
12379217
|
| D000255 | 5243 |
ABCB1
ABC20 CD243 CLCS GP170 MDR1 P-GP PGY1 |
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) | ABCB1 protein binds to and results in increased hydrolysis of Adenosine Triphosphate |
affects binding
/ increases hydrolysis |
protein |
14978246
|
| D000255 | 5243 |
ABCB1
ABC20 CD243 CLCS GP170 MDR1 P-GP PGY1 |
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) | ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate |
increases hydrolysis
|
protein |
22233293
|
| D000255 | 5243 |
ABCB1
ABC20 CD243 CLCS GP170 MDR1 P-GP PGY1 |
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) | crizotinib promotes the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate] |
increases hydrolysis
/ increases reaction |
protein |
22233293
|
| D000255 | 5243 |
ABCB1
ABC20 CD243 CLCS GP170 MDR1 P-GP PGY1 |
ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44) | Disulfiram affects the reaction [ABCB1 protein results in increased hydrolysis of Adenosine Triphosphate] |
affects reaction
/ increases hydrolysis |
protein |
14978246
|
| D000255 | 8647 |
ABCB11
ABC16 BRIC2 BSEP PFIC-2 PFIC2 PGY4 SPGP |
ATP-binding cassette, sub-family B (MDR/TAP), member 11 | Adenosine Triphosphate promotes the reaction [ABCB11 protein results in increased uptake of fexofenadine] |
increases reaction
/ increases uptake |
protein |
18245269
|
| D000255 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | ABCC1 protein binds to and results in increased degradation of Adenosine Triphosphate |
affects binding
/ increases degradation |
protein |
15459206
|
| D000255 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | ABCC1 protein binds to and results in increased hydrolysis of Adenosine Triphosphate |
affects binding
/ increases hydrolysis |
protein |
14978246
|
| D000255 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate |
increases hydrolysis
|
protein |
16156793
|
| D000255 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | Adenosine Triphosphate binds to ABCC1 protein |
affects binding
|
protein |
15355964
15737336 |
| D000255 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | Adenosine Triphosphate binds to and affects the folding of ABCC1 protein |
affects binding
/ affects folding |
protein |
11278000
15838832 |
| D000255 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Bilirubin] |
affects transport
/ increases reaction |
protein |
15245331
|
| D000255 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of estradiol-17 beta-glucuronide] |
affects transport
/ increases reaction |
protein |
15459206
|
| D000255 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | Adenosine Triphosphate promotes the reaction [ABCC1 protein affects the transport of Leukotriene C4] |
affects transport
/ increases reaction |
protein |
15355964
15459206 |
| D000255 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | daidzein promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate] |
increases hydrolysis
/ increases reaction |
protein |
16156793
|
| D000255 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | Disulfiram affects the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate] |
affects reaction
/ increases hydrolysis |
protein |
14978246
|
| D000255 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | hesperetin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate] |
increases hydrolysis
/ increases reaction |
protein |
16156793
|
| D000255 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | naringenin promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate] |
increases hydrolysis
/ increases reaction |
protein |
16156793
|
| D000255 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | Quercetin affects the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate] |
affects reaction
/ increases hydrolysis |
protein |
16156793
|
| D000255 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | resveratrol promotes the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate] |
increases hydrolysis
/ increases reaction |
protein |
16156793
|
| D000255 | 4363 |
ABCC1
ABC29 ABCC GS-X MRP MRP1 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 1 | Silymarin inhibits the reaction [ABCC1 protein results in increased hydrolysis of Adenosine Triphosphate] |
decreases reaction
/ increases hydrolysis |
protein |
16156793
|
| D000255 | 1244 |
ABCC2
ABC30 CMOAT DJS MRP2 cMRP |
ATP-binding cassette, sub-family C (CFTR/MRP), member 2 | ABCC2 protein affects the metabolism of Adenosine Triphosphate |
affects metabolic processing
|
protein |
22027652
|
| D000255 | 10257 |
ABCC4
EST170205 MOAT-B MOATB MRP4 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | ABCC4 protein binds to and results in increased hydrolysis of Adenosine Triphosphate |
affects binding
/ increases hydrolysis |
protein |
14978246
|
| D000255 | 10257 |
ABCC4
EST170205 MOAT-B MOATB MRP4 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate |
increases hydrolysis
|
protein |
16156793
|
| D000255 | 10257 |
ABCC4
EST170205 MOAT-B MOATB MRP4 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | daidzein promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate] |
increases hydrolysis
/ increases reaction |
protein |
16156793
|
| D000255 | 10257 |
ABCC4
EST170205 MOAT-B MOATB MRP4 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | Disulfiram inhibits the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate] |
decreases reaction
/ increases hydrolysis |
protein |
14978246
|
| D000255 | 10257 |
ABCC4
EST170205 MOAT-B MOATB MRP4 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | hesperetin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate] |
increases hydrolysis
/ increases reaction |
protein |
16156793
|
| D000255 | 10257 |
ABCC4
EST170205 MOAT-B MOATB MRP4 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | naringenin promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate] |
increases hydrolysis
/ increases reaction |
protein |
16156793
|
| D000255 | 10257 |
ABCC4
EST170205 MOAT-B MOATB MRP4 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | Quercetin affects the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate] |
affects reaction
/ increases hydrolysis |
protein |
16156793
|
| D000255 | 10257 |
ABCC4
EST170205 MOAT-B MOATB MRP4 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | Quercetin inhibits the reaction [Alprostadil promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]] |
decreases reaction
/ increases hydrolysis / increases reaction |
protein |
16156793
|
| D000255 | 10257 |
ABCC4
EST170205 MOAT-B MOATB MRP4 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | resveratrol promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate] |
increases hydrolysis
/ increases reaction |
protein |
16156793
|
| D000255 | 10257 |
ABCC4
EST170205 MOAT-B MOATB MRP4 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | Silymarin inhibits the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate] |
decreases reaction
/ increases hydrolysis |
protein |
16156793
|
| D000255 | 10257 |
ABCC4
EST170205 MOAT-B MOATB MRP4 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 4 | Silymarin inhibits the reaction [Alprostadil promotes the reaction [ABCC4 protein results in increased hydrolysis of Adenosine Triphosphate]] |
decreases reaction
/ increases hydrolysis / increases reaction |
protein |
16156793
|
| D000255 | 368 |
ABCC6
ABC34 ARA EST349056 GACI2 MLP1 MOAT-E MOATE MRP6 PXE PXE1 URG7 |
ATP-binding cassette, sub-family C (CFTR/MRP), member 6 | Adenosine Triphosphate binds to ABCC6 protein |
affects binding
|
protein |
11880368
|
| D000255 | 25 |
ABL1
ABL JTK7 bcr/abl c-ABL p150 v-abl |
c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) | [ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein |
affects cotreatment
/ increases phosphorylation |
protein |
19366808
|
| D000255 | 25 |
ABL1
ABL JTK7 bcr/abl c-ABL p150 v-abl |
c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2) | sorafenib inhibits the reaction [[ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein] |
affects cotreatment
/ decreases reaction / increases phosphorylation |
protein |
19366808
|
| D000255 | 238 |
ALK
CD246 NBLST3 |
anaplastic lymphoma receptor tyrosine kinase (EC:2.7.10.1) | ALK protein binds to Adenosine Triphosphate |
affects binding
|
protein |
22072639
|
| D000255 | 238 |
ALK
CD246 NBLST3 |
anaplastic lymphoma receptor tyrosine kinase (EC:2.7.10.1) | ALK protein mutant form promotes the reaction [ALK protein binds to Adenosine Triphosphate] |
affects binding
/ increases reaction |
protein |
22072639
|
| D000255 | 238 |
ALK
CD246 NBLST3 |
anaplastic lymphoma receptor tyrosine kinase (EC:2.7.10.1) | [ALK protein mutant form promotes the reaction [ALK protein binds to Adenosine Triphosphate]] which results in decreased susceptibility to crizotinib |
affects binding
/ decreases response to substance / increases reaction |
protein |
22072639
|
| D000255 | 538 |
ATP7A
DSMAX MK MNK SMAX3 |
ATPase, Cu++ transporting, alpha polypeptide (EC:3.6.3.54) | [Copper co-treated with Adenosine Triphosphate] results in increased phosphorylation of ATP7A protein |
affects cotreatment
/ increases phosphorylation |
protein |
20964302
|
| D000255 | 540 |
ATP7B
PWD WC1 WD WND |
ATPase, Cu++ transporting, beta polypeptide (EC:3.6.3.54) | Adenosine Triphosphate results in increased phosphorylation of ATP7B protein |
increases phosphorylation
|
protein |
19405516
|
| D000255 | 540 |
ATP7B
PWD WC1 WD WND |
ATPase, Cu++ transporting, beta polypeptide (EC:3.6.3.54) | [Copper co-treated with Adenosine Triphosphate] results in increased phosphorylation of ATP7B protein |
affects cotreatment
/ increases phosphorylation |
protein |
20964302
|
| D000255 | 596 |
BCL2
Bcl-2 PPP1R50 |
B-cell CLL/lymphoma 2 | [Adenosine Triphosphate binds to P2RY11 protein] which results in decreased expression of BCL2 protein |
affects binding
/ decreases expression |
protein |
21503959
|
| D000255 | 613 |
BCR
ALL BCR1 CML D22S11 D22S662 PHL |
breakpoint cluster region (EC:2.7.11.1) | [BCR protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein |
affects cotreatment
/ increases phosphorylation |
protein |
19366808
|
| D000255 | 613 |
BCR
ALL BCR1 CML D22S11 D22S662 PHL |
breakpoint cluster region (EC:2.7.11.1) | sorafenib inhibits the reaction [[BCR protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein] |
affects cotreatment
/ decreases reaction / increases phosphorylation |
protein |
19366808
|
| D000255 | 834 |
CASP1
ICE IL1BC P45 |
caspase 1, apoptosis-related cysteine peptidase (EC:3.4.22.36) | [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of CASP1 protein |
affects cotreatment
/ increases cleavage |
protein |
18604214
|
| D000255 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Adenosine Triphosphate results in increased expression of CASP3 |
increases expression
|
19448140
|
|
| D000255 | 836 |
CASP3
CPP32 CPP32B SCA-1 |
caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56) | Suramin inhibits the reaction [Adenosine Triphosphate results in increased expression of CASP3] |
decreases reaction
/ increases expression |
19448140
|
|
| D000255 | 847 |
CAT
|
catalase (EC:1.11.1.6) | Adenosine Triphosphate results in increased expression of CAT mRNA |
increases expression
|
mRNA |
22129738
|
| D000255 | 1080 |
CFTR
ABC35 ABCC7 CF CFTR/MRP MRP7 TNR-CFTR dJ760C5.1 |
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) | 3-((3-trifluoromethyl)phenyl)-5-((3-carboxyphenyl)methylene)-2-thioxo-4-thiazolidinone inhibits the reaction [Adenosine Triphosphate promotes the reaction [CFTR protein results in increased export of Chlorides]] |
decreases reaction
/ increases export / increases reaction |
protein |
20675434
|
| D000255 | 1080 |
CFTR
ABC35 ABCC7 CF CFTR/MRP MRP7 TNR-CFTR dJ760C5.1 |
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) | Adenosine Triphosphate affects the reaction [Curcumin results in increased activity of CFTR protein mutant form] |
affects reaction
/ increases activity |
protein |
17178710
|
| D000255 | 1080 |
CFTR
ABC35 ABCC7 CF CFTR/MRP MRP7 TNR-CFTR dJ760C5.1 |
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) | Adenosine Triphosphate binds to and results in increased activity of CFTR protein |
affects binding
/ increases activity |
protein |
15623556
|
| D000255 | 1080 |
CFTR
ABC35 ABCC7 CF CFTR/MRP MRP7 TNR-CFTR dJ760C5.1 |
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) | Adenosine Triphosphate promotes the reaction [CFTR protein results in increased export of Chlorides] |
increases export
/ increases reaction |
protein |
20675434
|
| D000255 | 1080 |
CFTR
ABC35 ABCC7 CF CFTR/MRP MRP7 TNR-CFTR dJ760C5.1 |
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) | [Phosphatidylinositol 4,5-Diphosphate co-treated with Adenosine Triphosphate] results in increased activity of CFTR protein |
affects cotreatment
/ increases activity |
protein |
14710196
|
| D000255 | 26973 |
CHORDC1
CHP1 |
cysteine and histidine-rich domain (CHORD) containing 1 | Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to PPP5C protein] |
affects binding
/ increases reaction |
protein |
23184943
|
| D000255 | 26973 |
CHORDC1
CHP1 |
cysteine and histidine-rich domain (CHORD) containing 1 | Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to SUGT1 protein] |
affects binding
/ increases reaction |
protein |
23184943
|
| D000255 | 1312 |
COMT
|
catechol-O-methyltransferase (EC:2.1.1.6) | [Carbonyl Cyanide p-Trifluoromethoxyphenylhydrazone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate |
decreases abundance
/ decreases activity |
protein |
14975680
|
| D000255 | 1312 |
COMT
|
catechol-O-methyltransferase (EC:2.1.1.6) | [tolcapone results in decreased activity of COMT protein] which results in decreased abundance of Adenosine Triphosphate |
decreases abundance
/ decreases activity |
protein |
14975680
|
| D000255 | 4514 |
COX3
COIII MTCO3 MT-CO3 |
cytochrome c oxidase III | COX3 protein results in increased abundance of Adenosine Triphosphate |
increases abundance
|
protein |
17428446
|
| D000255 | 1376 |
CPT2
CPT1 CPTASE IIAE4 |
carnitine palmitoyltransferase 2 (EC:2.3.1.21) | [Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate |
increases abundance
/ increases activity |
protein |
21816645
|
| D000255 | 1376 |
CPT2
CPT1 CPTASE IIAE4 |
carnitine palmitoyltransferase 2 (EC:2.3.1.21) | Carnitine promotes the reaction [[Bezafibrate results in increased activity of CPT2 protein] which results in increased abundance of Adenosine Triphosphate] |
increases abundance
/ increases activity / increases reaction |
protein |
21816645
|
| D000255 | 1399 |
CRKL
|
v-crk avian sarcoma virus CT10 oncogene homolog-like | [ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein |
affects cotreatment
/ increases phosphorylation |
protein |
19366808
|
| D000255 | 1399 |
CRKL
|
v-crk avian sarcoma virus CT10 oncogene homolog-like | [BCR protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein |
affects cotreatment
/ increases phosphorylation |
protein |
19366808
|
| D000255 | 1399 |
CRKL
|
v-crk avian sarcoma virus CT10 oncogene homolog-like | sorafenib inhibits the reaction [[ABL1 protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein] |
affects cotreatment
/ decreases reaction / increases phosphorylation |
protein |
19366808
|
| D000255 | 1399 |
CRKL
|
v-crk avian sarcoma virus CT10 oncogene homolog-like | sorafenib inhibits the reaction [[BCR protein mutant form co-treated with Adenosine Triphosphate] results in increased phosphorylation of CRKL protein] |
affects cotreatment
/ decreases reaction / increases phosphorylation |
protein |
19366808
|
| D000255 | 339221 |
ENPP7
ALK-SMase E-NPP_7 NPP-7 |
ectonucleotide pyrophosphatase/phosphodiesterase 7 (EC:3.1.4.12) | Adenosine Triphosphate results in decreased activity of ENPP7 protein |
decreases activity
|
protein |
12885774
|
| D000255 | 2147 |
F2
PT RPRGL2 THPH1 |
coagulation factor II (thrombin) (EC:3.4.21.5) | calmidazolium affects the reaction [F2 protein results in increased secretion of Adenosine Triphosphate] |
affects reaction
/ increases secretion |
protein |
2030746
|
| D000255 | 2147 |
F2
PT RPRGL2 THPH1 |
coagulation factor II (thrombin) (EC:3.4.21.5) | F2 protein results in increased abundance of Adenosine Triphosphate |
increases abundance
|
protein |
15342215
|
| D000255 | 2147 |
F2
PT RPRGL2 THPH1 |
coagulation factor II (thrombin) (EC:3.4.21.5) | F2 protein results in increased secretion of Adenosine Triphosphate |
increases secretion
|
protein |
2030746
|
| D000255 | 2147 |
F2
PT RPRGL2 THPH1 |
coagulation factor II (thrombin) (EC:3.4.21.5) | Fendiline affects the reaction [F2 protein results in increased secretion of Adenosine Triphosphate] |
affects reaction
/ increases secretion |
protein |
2030746
|
| D000255 | 2147 |
F2
PT RPRGL2 THPH1 |
coagulation factor II (thrombin) (EC:3.4.21.5) | Quercetin inhibits the reaction [F2 protein results in increased abundance of Adenosine Triphosphate] |
decreases reaction
/ increases abundance |
protein |
15342215
|
| D000255 | 2147 |
F2
PT RPRGL2 THPH1 |
coagulation factor II (thrombin) (EC:3.4.21.5) | resveratrol inhibits the reaction [F2 protein results in increased abundance of Adenosine Triphosphate] |
decreases reaction
/ increases abundance |
protein |
15342215
|
| D000255 | 2597 |
GAPDH
G3PD GAPD |
glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12) | Adenosine Triphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog] |
affects cotreatment
/ decreases reaction / increases reduction |
protein |
15788719
|
| D000255 | 2688 |
GH1
GH GH-N GHN IGHD1B hGH-N |
growth hormone 1 | Adenosine Triphosphate results in increased secretion of GH1 protein |
increases secretion
|
protein |
12471042
|
| D000255 | 2688 |
GH1
GH GH-N GHN IGHD1B hGH-N |
growth hormone 1 | oxophenylarsine inhibits the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein] |
decreases reaction
/ increases secretion |
protein |
12471042
|
| D000255 | 2688 |
GH1
GH GH-N GHN IGHD1B hGH-N |
growth hormone 1 | Phosphatidylinositol 4,5-Diphosphate affects the reaction [Adenosine Triphosphate results in increased secretion of GH1 protein] |
affects reaction
/ increases secretion |
protein |
12471042
|
| D000255 | 2697 |
GJA1
AVSD3 CMDR CX43 DFNB38 GJAL HLHS1 HSS ODDD |
gap junction protein, alpha 1, 43kDa | GJA1 protein mutant form results in increased export of Adenosine Triphosphate |
increases export
|
protein |
17687502
|
| D000255 | 2697 |
GJA1
AVSD3 CMDR CX43 DFNB38 GJAL HLHS1 HSS ODDD |
gap junction protein, alpha 1, 43kDa | GJA1 protein results in increased export of Adenosine Triphosphate |
increases export
|
protein |
17687502
|
| D000255 | 2950 |
GSTP1
DFN7 FAEES3 GST3 GSTP PI |
glutathione S-transferase pi 1 (EC:2.5.1.18) | [GSTP1 protein co-treated with Glutathione] inhibits the reaction [Adenosine Triphosphate results in increased activity of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine] |
affects cotreatment
/ decreases reaction / increases activity |
protein |
11196146
|
| D000255 | 2950 |
GSTP1
DFN7 FAEES3 GST3 GSTP PI |
glutathione S-transferase pi 1 (EC:2.5.1.18) | [GSTP1 protein co-treated with Glutathione] inhibits the reaction [[Adenosine Triphosphate results in increased metabolism of 2-hydroxyamino-1-methyl-6-phenylimidazo(4,5-b)pyridine] which results in increased abundance of 2-amino-1-methyl-6-phenolimidazo(4,5-b)pyridine-DNA adduct] |
affects cotreatment
/ decreases reaction / increases abundance / increases metabolic processing |
protein |
11196146
|
| D000255 | 3383 |
ICAM1
BB2 CD54 P3.58 |
intercellular adhesion molecule 1 | Adenosine Triphosphate inhibits the reaction [Fructose results in increased expression of ICAM1 protein] |
decreases reaction
/ increases expression |
protein |
18508964
|
| D000255 | 3593 |
IL12B
CLMF CLMF2 IL-12B NKSF NKSF2 |
interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40) | Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL12B protein] |
decreases reaction
/ increases expression |
protein |
17707769
|
| D000255 | 3606 |
IL18
IGIF IL-18 IL-1g IL1F4 |
interleukin 18 (interferon-gamma-inducing factor) | [Adenosine Triphosphate co-treated with K-12 lipopolysaccharide] results in increased secretion of IL18 protein |
affects cotreatment
/ increases secretion |
protein |
17404311
|
| D000255 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | [Adenosine Triphosphate co-treated with K-12 lipopolysaccharide] results in increased secretion of IL1B protein modified form |
affects cotreatment
/ increases secretion |
protein |
17404311
|
| D000255 | 3553 |
IL1B
IL-1 IL1-BETA IL1F2 |
interleukin 1, beta | [Lipopolysaccharides co-treated with Adenosine Triphosphate] results in increased cleavage of and results in increased secretion of IL1B protein |
affects cotreatment
/ increases cleavage / increases secretion |
protein |
18604214
|
| D000255 | 3569 |
IL6
BSF2 HGF HSF IFNB2 IL-6 |
interleukin 6 (interferon, beta 2) | Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of IL6 protein] |
decreases reaction
/ increases expression |
protein |
17707769
|
| D000255 | 3630 |
INS
IDDM2 ILPR IRDN MODY10 |
insulin | [ammonium ferrous sulfate results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate |
increases activity
/ increases secretion |
protein |
17965850
|
| D000255 | 3630 |
INS
IDDM2 ILPR IRDN MODY10 |
insulin | [chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate |
increases activity
/ increases secretion |
protein |
17965850
|
| D000255 | 3630 |
INS
IDDM2 ILPR IRDN MODY10 |
insulin | Mannose inhibits the reaction [[chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate] |
decreases reaction
/ increases activity / increases secretion |
protein |
17965850
|
| D000255 | 3630 |
INS
IDDM2 ILPR IRDN MODY10 |
insulin | Phloretin inhibits the reaction [[chromic chloride results in increased activity of INS protein modified form] which results in increased secretion of Adenosine Triphosphate] |
decreases reaction
/ increases activity / increases secretion |
protein |
17965850
|
| D000255 | 26548 |
ITGB1BP2
CHORDC3 ITGB1BP MELUSIN |
integrin beta 1 binding protein (melusin) 2 | Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to PPP5C protein] |
affects binding
/ increases reaction |
protein |
23184943
|
| D000255 | 26548 |
ITGB1BP2
CHORDC3 ITGB1BP MELUSIN |
integrin beta 1 binding protein (melusin) 2 | Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to SUGT1 protein] |
affects binding
/ increases reaction |
protein |
23184943
|
| D000255 | 26548 |
ITGB1BP2
CHORDC3 ITGB1BP MELUSIN |
integrin beta 1 binding protein (melusin) 2 | Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to SUGT1 protein]] |
affects binding
/ increases reaction |
protein |
23184943
|
| D000255 | 3772 |
KCNJ15
IRKK KIR1.3 KIR4.2 |
potassium inwardly-rectifying channel, subfamily J, member 15 | Adenosine Triphosphate results in increased activity of KCNJ15 protein |
increases activity
|
protein |
15328350
|
| D000255 | 3795 |
KHK
|
ketohexokinase (fructokinase) (EC:2.7.1.3) | KHK protein promotes the reaction [Fructose results in decreased abundance of Adenosine Triphosphate] |
decreases abundance
/ increases reaction |
protein |
19158351
|
| D000255 | 3991 |
LIPE
HSL LHS |
lipase, hormone-sensitive (EC:3.1.1.79) | Adenosine Triphosphate results in increased activity of LIPE protein |
increases activity
|
protein |
7155675
|
| D000255 | 4023 |
LPL
HDLCQ11 LIPD |
lipoprotein lipase (EC:3.1.1.34) | LPL protein affects the susceptibility to Adenosine Triphosphate |
affects response to substance
|
protein |
11786490
|
| D000255 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein] |
decreases reaction
/ increases phosphorylation |
protein |
15034929
|
| D000255 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | Adenosine Triphosphate results in increased phosphorylation of MAPK1 protein |
increases phosphorylation
|
protein |
15034929
21503959 |
| D000255 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | 1-(6-((3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione inhibits the reaction [Adenosine Triphosphate results in increased phosphorylation of MAPK3 protein] |
decreases reaction
/ increases phosphorylation |
protein |
15034929
|
| D000255 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | Adenosine Triphosphate results in increased phosphorylation of MAPK3 protein |
increases phosphorylation
|
protein |
15034929
21503959 |
| D000255 | 55191 |
NADSYN1
|
NAD synthetase 1 (EC:6.3.5.1) | [Ammonium Chloride co-treated with nicotinic acid adenine dinucleotide co-treated with Adenosine Triphosphate] results in increased activity of NADSYN1 protein |
affects cotreatment
/ increases activity |
protein |
12547821
|
| D000255 | 55191 |
NADSYN1
|
NAD synthetase 1 (EC:6.3.5.1) | [NADSYN1 protein co-treated with Ammonium Chloride co-treated with nicotinic acid adenine dinucleotide co-treated with Adenosine Triphosphate] results in increased chemical synthesis of NAD |
affects cotreatment
/ increases chemical synthesis |
protein |
12547821
|
| D000255 | 114548 |
NLRP3
AGTAVPRL AII AVP C1orf7 CIAS1 CLR1.1 FCAS FCU MWS NALP3 PYPAF1 |
NLR family, pyrin domain containing 3 | [Adenosine Triphosphate co-treated with Lipopolysaccharides] results in increased activity of NLRP3 protein |
affects cotreatment
/ increases activity |
protein |
18604214
|
| D000255 | 9221 |
NOLC1
NOPP130 NOPP140 NS5ATP13 P130 |
nucleolar and coiled-body phosphoprotein 1 | Adenosine Triphosphate affects the reaction [Doxorubicin binds to NOLC1 protein] |
affects binding
/ affects reaction |
protein |
17129415
|
| D000255 | 4843 |
NOS2
HEP-NOS INOS NOS NOS2A |
nitric oxide synthase 2, inducible (EC:1.14.13.39) | NOS2 protein affects the reaction [Adenosine Triphosphate results in increased metabolism of RELA protein] |
affects reaction
/ increases metabolic processing |
protein |
21464294
|
| D000255 | 4852 |
NPY
PYY4 |
neuropeptide Y | NPY protein affects the susceptibility to Adenosine Triphosphate |
affects response to substance
|
protein |
15003356
|
| D000255 | 4938 |
OAS1
IFI-4 OIAS OIASI |
2'-5'-oligoadenylate synthetase 1, 40/46kDa (EC:2.7.7.84) | [OAS1 protein results in increased metabolism of Adenosine Triphosphate] which results in increased chemical synthesis of 2',5'-oligoadenylate |
increases chemical synthesis
/ increases metabolic processing |
protein |
15732009
|
| D000255 | 5027 |
P2RX7
P2X7 |
purinergic receptor P2X, ligand-gated ion channel, 7 | Adenosine Triphosphate results in increased activity of P2RX7 protein |
increases activity
|
protein |
19023039
|
| D000255 | 5027 |
P2RX7
P2X7 |
purinergic receptor P2X, ligand-gated ion channel, 7 | P2RX7 protein affects the reaction [Adenosine Triphosphate results in increased secretion of SELL protein] |
affects reaction
/ increases secretion |
protein |
11003599
|
| D000255 | 5027 |
P2RX7
P2X7 |
purinergic receptor P2X, ligand-gated ion channel, 7 | P2RX7 protein affects the reaction [Adenosine Triphosphate results in increased transport of Barium] |
affects reaction
/ increases transport |
protein |
11003599
|
| D000255 | 5028 |
P2RY1
P2Y1 |
purinergic receptor P2Y, G-protein coupled, 1 | Adenosine Triphosphate binds to and results in increased activity of P2RY1 protein |
affects binding
/ increases activity |
protein |
12694404
|
| D000255 | 5028 |
P2RY1
P2Y1 |
purinergic receptor P2Y, G-protein coupled, 1 | [Adenosine Triphosphate binds to and results in increased activity of P2RY1 protein] which results in increased abundance of Calcium |
affects binding
/ increases abundance / increases activity |
protein |
12694404
|
| D000255 | 5028 |
P2RY1
P2Y1 |
purinergic receptor P2Y, G-protein coupled, 1 | N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [P2RY1 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]] |
decreases reaction
/ decreases response to substance / increases reaction |
protein |
22129738
|
| D000255 | 5028 |
P2RY1
P2Y1 |
purinergic receptor P2Y, G-protein coupled, 1 | P2RY1 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide] |
decreases response to substance
/ increases reaction |
protein |
22129738
|
| D000255 | 5028 |
P2RY1
P2Y1 |
purinergic receptor P2Y, G-protein coupled, 1 | Trichloroethylene inhibits the reaction [[Adenosine Triphosphate binds to and results in increased activity of P2RY1 protein] which results in increased abundance of Calcium] |
affects binding
/ decreases reaction / increases abundance / increases activity |
protein |
12694404
|
| D000255 | 5032 |
P2RY11
P2Y11 |
purinergic receptor P2Y, G-protein coupled, 11 | Adenosine Triphosphate binds to P2RY11 protein |
affects binding
|
protein |
21503959
|
| D000255 | 5032 |
P2RY11
P2Y11 |
purinergic receptor P2Y, G-protein coupled, 11 | [Adenosine Triphosphate binds to P2RY11 protein] which results in decreased expression of BCL2 protein |
affects binding
/ decreases expression |
protein |
21503959
|
| D000255 | 5032 |
P2RY11
P2Y11 |
purinergic receptor P2Y, G-protein coupled, 11 | [Adenosine Triphosphate binds to P2RY11 protein] which results in increased susceptibility to Cisplatin |
affects binding
/ increases response to substance |
protein |
21503959
|
| D000255 | 53829 |
P2RY13
GPCR1 GPR86 GPR94 P2Y13 SP174 |
purinergic receptor P2Y, G-protein coupled, 13 | MRS 2211 inhibits the reaction [P2RY13 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]] |
decreases reaction
/ decreases response to substance / increases reaction |
protein |
22129738
|
| D000255 | 53829 |
P2RY13
GPCR1 GPR86 GPR94 P2Y13 SP174 |
purinergic receptor P2Y, G-protein coupled, 13 | P2RY13 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide] |
decreases response to substance
/ increases reaction |
protein |
22129738
|
| D000255 | 5029 |
P2RY2
HP2U P2RU1 P2U P2U1 P2UR P2Y2 P2Y2R |
purinergic receptor P2Y, G-protein coupled, 2 | Adenosine Triphosphate results in increased activity of P2RY2 protein |
increases activity
|
protein |
11527950
|
| D000255 | 5029 |
P2RY2
HP2U P2RU1 P2U P2U1 P2UR P2Y2 P2Y2R |
purinergic receptor P2Y, G-protein coupled, 2 | [Adenosine Triphosphate results in increased activity of P2RY2 protein] which results in increased abundance of Calcium |
increases abundance
/ increases activity |
protein |
11527950
|
| D000255 | 5030 |
P2RY4
NRU P2P P2Y4 UNR |
pyrimidinergic receptor P2Y, G-protein coupled, 4 | Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein |
affects binding
/ increases activity |
protein |
12694404
|
| D000255 | 5030 |
P2RY4
NRU P2P P2Y4 UNR |
pyrimidinergic receptor P2Y, G-protein coupled, 4 | [Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium |
affects binding
/ increases abundance / increases activity |
protein |
12694404
|
| D000255 | 5030 |
P2RY4
NRU P2P P2Y4 UNR |
pyrimidinergic receptor P2Y, G-protein coupled, 4 | Trichloroethylene inhibits the reaction [[Adenosine Triphosphate binds to and results in increased activity of P2RY4 protein] which results in increased abundance of Calcium] |
affects binding
/ decreases reaction / increases abundance / increases activity |
protein |
12694404
|
| D000255 | 5031 |
P2RY6
P2Y6 |
pyrimidinergic receptor P2Y, G-protein coupled, 6 | N,N''-1,4-butanediylbis(N'-(3-isothiocyanatophenyl))thiourea inhibits the reaction [P2RY6 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide]] |
decreases reaction
/ decreases response to substance / increases reaction |
protein |
22129738
|
| D000255 | 5031 |
P2RY6
P2Y6 |
pyrimidinergic receptor P2Y, G-protein coupled, 6 | P2RY6 protein promotes the reaction [Adenosine Triphosphate results in decreased susceptibility to Hydrogen Peroxide] |
decreases response to substance
/ increases reaction |
protein |
22129738
|
| D000255 | 24145 |
PANX1
MRS1 PX1 UNQ2529 |
pannexin 1 | Adenosine Triphosphate results in decreased activity of PANX1 protein |
decreases activity
|
protein |
19023039
|
| D000255 | 24145 |
PANX1
MRS1 PX1 UNQ2529 |
pannexin 1 | Carbenoxolone inhibits the reaction [PANX1 protein results in increased export of Adenosine Triphosphate] |
decreases reaction
/ increases export |
protein |
19213873
|
| D000255 | 24145 |
PANX1
MRS1 PX1 UNQ2529 |
pannexin 1 | PANX1 protein results in increased export of Adenosine Triphosphate |
increases export
|
protein |
19213873
|
| D000255 | 24145 |
PANX1
MRS1 PX1 UNQ2529 |
pannexin 1 | Probenecid inhibits the reaction [PANX1 protein results in increased export of Adenosine Triphosphate] |
decreases reaction
/ increases export |
protein |
19213873
|
| D000255 | 142 |
PARP1
ADPRT ADPRT_1 ADPRT1 ARTD1 PARP PARP-1 PPOL pADPRT-1 |
poly (ADP-ribose) polymerase 1 (EC:2.4.2.30) | PARP1 mutant form inhibits the reaction [Cadmium results in decreased abundance of Adenosine Triphosphate] |
decreases abundance
/ decreases reaction |
mutant form |
21767558
|
| D000255 | 5290 |
PIK3CA
CLOVE CWS5 MCAP MCM MCMTC PI3K p110-alpha |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (EC:2.7.11.1 2.7.1.153) | 2-(1H-indazol-4-yl)-6-(4-methanesulfonylpiperazin-1-ylmethyl)-4-morpholin-4-ylthieno(3,2-d)pyrimidine inhibits the reaction [Adenosine Triphosphate binds to PIK3CA protein] |
affects binding
/ decreases reaction |
protein |
18754654
|
| D000255 | 5290 |
PIK3CA
CLOVE CWS5 MCAP MCM MCMTC PI3K p110-alpha |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (EC:2.7.11.1 2.7.1.153) | Adenosine Triphosphate binds to PIK3CA protein |
affects binding
|
protein |
18754654
|
| D000255 | 5290 |
PIK3CA
CLOVE CWS5 MCAP MCM MCMTC PI3K p110-alpha |
phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (EC:2.7.11.1 2.7.1.153) | Adenosine Triphosphate inhibits the reaction [resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]] |
affects binding
/ decreases activity / decreases reaction |
protein |
17550345
|
| D000255 | 5295 |
PIK3R1
AGM7 GRB1 p85 p85-ALPHA |
phosphoinositide-3-kinase, regulatory subunit 1 (alpha) | Adenosine Triphosphate inhibits the reaction [resveratrol results in decreased activity of [PIK3R1 protein binds to PIK3CA protein]] |
affects binding
/ decreases activity / decreases reaction |
protein |
17550345
|
| D000255 | 5536 |
PPP5C
PP5 PPP5 PPT |
protein phosphatase 5, catalytic subunit (EC:3.1.3.16) | Adenosine Triphosphate binds to and affects the folding of PPP5C protein |
affects binding
/ affects folding |
protein |
23184943
|
| D000255 | 5536 |
PPP5C
PP5 PPP5 PPT |
protein phosphatase 5, catalytic subunit (EC:3.1.3.16) | Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to PPP5C protein] |
affects binding
/ increases reaction |
protein |
23184943
|
| D000255 | 5536 |
PPP5C
PP5 PPP5 PPT |
protein phosphatase 5, catalytic subunit (EC:3.1.3.16) | Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to PPP5C protein] |
affects binding
/ increases reaction |
protein |
23184943
|
| D000255 | 5578 |
PRKCA
AAG6 PKC-alpha PKCA PRKACA |
protein kinase C, alpha (EC:2.7.11.13) | [[Adenosine Triphosphate co-treated with PRKCA protein] results in increased phosphorylation of RALBP1 protein] which results in increased transport of Doxorubicin |
affects cotreatment
/ increases phosphorylation / increases transport |
protein |
16087181
|
| D000255 | 10928 |
RALBP1
RIP1 RLIP1 RLIP76 |
ralA binding protein 1 | [[Adenosine Triphosphate co-treated with PRKCA protein] results in increased phosphorylation of RALBP1 protein] which results in increased transport of Doxorubicin |
affects cotreatment
/ increases phosphorylation / increases transport |
protein |
16087181
|
| D000255 | 10928 |
RALBP1
RIP1 RLIP1 RLIP76 |
ralA binding protein 1 | Adenosine Triphosphate promotes the reaction [RALBP1 protein affects the transport of Leukotriene C4] |
affects transport
/ increases reaction |
protein |
15386349
|
| D000255 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | NOS2 protein affects the reaction [Adenosine Triphosphate results in increased metabolism of RELA protein] |
affects reaction
/ increases metabolic processing |
protein |
21464294
|
| D000255 | 5970 |
RELA
NFKB3 p65 |
v-rel avian reticuloendotheliosis viral oncogene homolog A | S-Nitrosoglutathione promotes the reaction [Adenosine Triphosphate results in increased metabolism of RELA protein] |
increases metabolic processing
/ increases reaction |
protein |
21464294
|
| D000255 | 6402 |
SELL
CD62L LAM1 LECAM1 LEU8 LNHR LSEL LYAM1 PLNHR TQ1 |
selectin L | P2RX7 protein affects the reaction [Adenosine Triphosphate results in increased secretion of SELL protein] |
affects reaction
/ increases secretion |
protein |
11003599
|
| D000255 | 653509 |
SFTPA1
COLEC4 PSAP PSP-A PSPA SFTP1 SFTPA1B SP-A SP-A1 SPA SPA1 |
surfactant protein A1 | Ozone inhibits the reaction [[SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]] |
affects binding
/ decreases reaction / increases secretion |
protein |
15065867
|
| D000255 | 653509 |
SFTPA1
COLEC4 PSAP PSP-A PSPA SFTP1 SFTPA1B SP-A SP-A1 SPA SPA1 |
surfactant protein A1 | Ozone inhibits the reaction [SFTPA1 protein polymorphism inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]] |
decreases reaction
/ increases secretion |
protein |
15065867
|
| D000255 | 653509 |
SFTPA1
COLEC4 PSAP PSP-A PSPA SFTP1 SFTPA1B SP-A SP-A1 SPA SPA1 |
surfactant protein A1 | [SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines] |
affects binding
/ decreases reaction / increases secretion |
protein |
15065867
|
| D000255 | 729238 |
SFTPA2
COLEC5 PSAP PSP-A PSPA SFTP1 SFTPA2B SP-A SPA2 SPAII |
surfactant protein A2 | Ozone inhibits the reaction [[SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]] |
affects binding
/ decreases reaction / increases secretion |
protein |
15065867
|
| D000255 | 729238 |
SFTPA2
COLEC5 PSAP PSP-A PSPA SFTP1 SFTPA2B SP-A SPA2 SPAII |
surfactant protein A2 | Ozone inhibits the reaction [SFTPA2 protein polymorphism inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines]] |
decreases reaction
/ increases secretion |
protein |
15065867
|
| D000255 | 729238 |
SFTPA2
COLEC5 PSAP PSP-A PSPA SFTP1 SFTPA2B SP-A SPA2 SPAII |
surfactant protein A2 | [SFTPA1 protein polymorphism binds to SFTPA2 protein polymorphism] inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines] |
affects binding
/ decreases reaction / increases secretion |
protein |
15065867
|
| D000255 | 729238 |
SFTPA2
COLEC5 PSAP PSP-A PSPA SFTP1 SFTPA2B SP-A SPA2 SPAII |
surfactant protein A2 | SFTPA2 protein polymorphism inhibits the reaction [Adenosine Triphosphate results in increased secretion of Phosphatidylcholines] |
decreases reaction
/ increases secretion |
protein |
15065867
|
| D000255 | 9016 |
SLC25A14
BMCP1 UCP5 |
solute carrier family 25 (mitochondrial carrier, brain), member 14 | SLC25A14 protein results in decreased chemical synthesis of Adenosine Triphosphate |
decreases chemical synthesis
|
protein |
20600837
|
| D000255 | 6513 |
SLC2A1
DYT17 DYT18 DYT9 EIG12 GLUT GLUT1 GLUT1DS HTLVR PED |
solute carrier family 2 (facilitated glucose transporter), member 1 | Adenosine Triphosphate results in decreased stability of SLC2A1 protein |
decreases stability
|
protein |
11420438
|
| D000255 | 6528 |
SLC5A5
NIS TDH1 |
solute carrier family 5 (sodium/iodide cotransporter), member 5 | Adenosine Triphosphate inhibits the reaction [TSHB protein results in increased expression of SLC5A5 protein] |
decreases reaction
/ increases expression |
protein |
16439463
|
| D000255 | 6647 |
SOD1
ALS ALS1 IPOA SOD hSod1 homodimer |
superoxide dismutase 1, soluble (EC:1.15.1.1) | Adenosine Triphosphate results in increased expression of SOD1 protein |
increases expression
|
protein |
22129738
|
| D000255 | 10910 |
SUGT1
SGT1 |
SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) | Adenosine Triphosphate promotes the reaction [CHORDC1 protein binds to SUGT1 protein] |
affects binding
/ increases reaction |
protein |
23184943
|
| D000255 | 10910 |
SUGT1
SGT1 |
SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) | Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to SUGT1 protein] |
affects binding
/ increases reaction |
protein |
23184943
|
| D000255 | 10910 |
SUGT1
SGT1 |
SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae) | Calcium promotes the reaction [Adenosine Triphosphate promotes the reaction [ITGB1BP2 protein binds to SUGT1 protein]] |
affects binding
/ increases reaction |
protein |
23184943
|
| D000255 | 7124 |
TNF
DIF TNF-alpha TNFA TNFSF2 |
tumor necrosis factor | Adenosine Triphosphate inhibits the reaction [Lipopolysaccharides results in increased expression of TNF protein] |
decreases reaction
/ increases expression |
protein |
17707769
|
| D000255 | 7153 |
TOP2A
TOP2 TP2A |
topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) | Emodin inhibits the reaction [TOP2A results in increased hydrolysis of Adenosine Triphosphate] |
decreases reaction
/ increases hydrolysis |
20855424
|
|
| D000255 | 7153 |
TOP2A
TOP2 TP2A |
topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3) | TOP2A results in increased hydrolysis of Adenosine Triphosphate |
increases hydrolysis
|
20855424
|
|
| D000255 | 7157 |
TP53
BCC7 LFS1 P53 TRP53 |
tumor protein p53 | TP53 protein inhibits the reaction [Deoxyglucose results in decreased abundance of Adenosine Triphosphate] |
decreases abundance
/ decreases reaction |
protein |
21042727
|
| D000255 | 7252 |
TSHB
TSH-B TSH-BETA |
thyroid stimulating hormone, beta | Adenosine Triphosphate inhibits the reaction [TSHB protein results in increased expression of SLC5A5 protein] |
decreases reaction
/ increases expression |
protein |
16439463
|
| D000255 | 7295 |
TXN
TRDX TRX TRX1 |
thioredoxin | Adenosine Triphosphate results in increased expression of TXN protein |
increases expression
|
protein |
22129738
|
| D000255 | 7351 |
UCP2
BMIQ4 SLC25A8 UCPH |
uncoupling protein 2 (mitochondrial, proton carrier) | Adenosine Triphosphate inhibits the reaction [UCP2 protein results in increased transport of Protons] |
decreases reaction
/ increases transport |
protein |
12734183
|
| D000255 | 7352 |
UCP3
SLC25A9 |
uncoupling protein 3 (mitochondrial, proton carrier) | Adenosine Triphosphate inhibits the reaction [UCP3 protein results in increased transport of Protons] |
decreases reaction
/ increases transport |
protein |
12734183
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (17)
| OMIM | preferred title | UniProt |
|---|---|---|
| #609821 | Bleeding disorder, platelet-type, 8; bdplt8 |
Q9H244
|
| #115200 | Cardiomyopathy, dilated, 1a; cmd1a |
P02545
|
| #212112 | Cardiomyopathy, dilated, with hypergonadotropic hypogonadism |
P02545
|
| #605588 | Charcot-marie-tooth disease, axonal, type 2b1; cmt2b1 |
P02545
|
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm |
P31751
|
| #181350 | Emery-dreifuss muscular dystrophy 2, autosomal dominant; edmd2 |
P02545
|
| #610140 | Heart-hand syndrome, slovenian type |
P02545
|
| #176670 | Hutchinson-gilford progeria syndrome; hgps |
P02545
|
| #307030 | Hyperglycerolemia |
P32189
|
| #240900 | Hypoinsulinemic hypoglycemia with hemihypertrophy; hihghh |
P31751
|
| #608232 | Leukemia, chronic myeloid; cml |
P00519
|
| #151660 | Lipodystrophy, familial partial, type 2; fpld2 |
P02545
|
| #211980 | Lung cancer |
P00533
|
| #248370 | Mandibuloacral dysplasia with type a lipodystrophy; mada |
P02545
|
| #613205 | Muscular dystrophy, congenital, lmna-related |
P02545
|
| #159001 | Muscular dystrophy, limb-girdle, type 1b; lgmd1b |
P02545
|
| #275210 | Restrictive dermopathy, lethal |
P02545
|
KEGG DISEASE (24)
| KEGG | disease name | UniProt |
|---|---|---|
| H00018 | Gastric cancer |
O96020
(related)
P00533 (related) P24864 (related) |
| H00055 | Laryngeal cancer |
O96020
(related)
P00533 (related) P00533 (marker) P24864 (related) |
| H00001 | Acute lymphoblastic leukemia (ALL) (precursor B lymphoblastic leukemia) |
P00519
(related)
P00519 (marker) |
| H00004 | Chronic myeloid leukemia (CML) |
P00519
(related)
P00519 (marker) |
| H00016 | Oral cancer |
P00533
(related)
P00533 (marker) |
| H00017 | Esophageal cancer |
P00533
(related)
|
| H00022 | Bladder cancer |
P00533
(related)
|
| H00028 | Choriocarcinoma |
P00533
(related)
|
| H00030 | Cervical cancer |
P00533
(related)
|
| H00042 | Glioma |
P00533
(related)
P00533 (marker) |
| H00264 | Charcot-Marie-Tooth disease (CMT) |
P02545
(related)
|
| H00294 | Dilated cardiomyopathy (DCM) |
P02545
(related)
|
| H00420 | Familial partial lipodystrophy (FPL) |
P02545
(related)
P31751 (related) |
| H00563 | Emery-Dreifuss muscular dystrophy |
P02545
(related)
|
| H00590 | Congenital muscular dystrophies (CMD/MDC) |
P02545
(related)
|
| H00593 | Limb-girdle muscular dystrophy (LGMD) |
P02545
(related)
|
| H00601 | Hutchinson-Gilford progeria syndrome |
P02545
(related)
|
| H00663 | Restrictive dermopathy |
P02545
(related)
|
| H00665 | Mandibuloacral dysplasia |
P02545
(related)
|
| H01216 | Left ventricular noncompaction (LVNC) |
P02545
(related)
|
| H00005 | Chronic lymphocytic leukemia (CLL) |
P04183
(marker)
|
| H00027 | Ovarian cancer |
P31751
(related)
|
| H00552 | Glycerol kinase deficiency (GKD) |
P32189
(related)
|
| H01235 | Bleeding disorder platelet-type |
Q9H244
(related)
|
Diseases related to CTD interactions
34 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D000138 | D000255 | Acidosis |
marker/mechanism
|
1433833
6483146 |
|
| D000419 | D000255 | Albuminuria |
marker/mechanism
|
20223894
|
|
| D001145 | D000255 | Arrhythmias, Cardiac |
marker/mechanism
|
6483146
|
|
| D001281 | D000255 | Atrial Fibrillation |
marker/mechanism
|
6711446
20938414 |
|
| D054537 | D000255 | Atrioventricular Block |
marker/mechanism
|
12381087
12570950 17905524 |
|
| D001919 | D000255 | Bradycardia |
marker/mechanism
|
9304156
|
|
| D018287 | D000255 | Carcinoma, Large Cell |
therapeutic
|
20156429
|
|
| D016534 | D000255 | Cardiac Output, High |
marker/mechanism
|
6575152
|
|
| D006332 | D000255 | Cardiomegaly |
marker/mechanism
|
8896075
|
|
| D002386 | D000255 | Cataract |
marker/mechanism
|
15003327
|
|
| D002637 | D000255 | Chest Pain |
marker/mechanism
|
8699994
9740548 12381087 |
|
| D056486 | D000255 | Drug-Induced Liver Injury |
marker/mechanism
|
22387747
|
|
| D004417 | D000255 | Dyspnea |
marker/mechanism
|
8699994
9740548 |
|
| D005119 | D000255 | Extravasation of Diagnostic and Therapeutic Materials |
therapeutic
|
10729373
|
|
| D006261 | D000255 | Headache |
marker/mechanism
|
12381087
|
|
| D006323 | D000255 | Heart Arrest |
marker/mechanism
|
11446933
|
|
| D006940 | D000255 | Hyperemia |
marker/mechanism
|
3813054
9840701 12381087 12794626 |
|
| D007022 | D000255 | Hypotension |
marker/mechanism
|
1433833
2355452 3813054 6483146 6575152 6703364 7147232 8476108 9830640 9840701 15235850 15278582 15616064 |
|
| D019586 | D000255 | Intracranial Hypertension |
marker/mechanism
|
6703364
|
|
| D008175 | D000255 | Lung Neoplasms |
therapeutic
|
20156429
|
|
| D008199 | D000255 | Lymphadenitis |
marker/mechanism
|
11062715
|
|
| D008575 | D000255 | Meniere Disease |
therapeutic
|
11700197
|
|
| D009336 | D000255 | Necrosis |
marker/mechanism
|
18984060
|
|
| D009369 | D000255 | Neoplasms |
marker/mechanism
therapeutic |
8699994
11062715 |
|
| D000857 | D000255 | Olfaction Disorders |
therapeutic
|
21865290
|
|
| D010146 | D000255 | Pain |
marker/mechanism
|
10825361
|
|
| D011248 | D000255 | Pregnancy Complications |
marker/mechanism
|
20223894
|
|
| D015427 | D000255 | Reperfusion Injury |
marker/mechanism
|
17997382
|
|
| D013226 | D000255 | Status Epilepticus |
marker/mechanism
|
10344793
|
|
| D013611 | D000255 | Tachycardia, Atrioventricular Nodal Reentry |
therapeutic
|
9973017
|
|
| D013614 | D000255 | Tachycardia, Paroxysmal |
therapeutic
|
2807609
6711446 |
|
| D013617 | D000255 | Tachycardia, Supraventricular |
therapeutic
|
2327421
2807609 6711446 |
|
| D017180 | D000255 | Tachycardia, Ventricular |
therapeutic
|
9809951
|
|
| D053201 | D000255 | Urinary Bladder, Overactive |
marker/mechanism
|
12700886
15780404 |