KCF-S cluster No. 2262 (5 metabolites)

• Index
• Plant Species
• KEGG BRITE br08003
• Metabolite list (5)
• Human Protein
  / Gene in interactions
• Related Diseases

Plant Species

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Cumulative plant class count

class name	count
rosids	1

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Cumulative family count

class name	count
Enterobacteriaceae	4
Brassicaceae	1
Pseudomonadaceae	1

KEGG BRITE br08003

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Categories (0)

br08003 Category	# of metabolite

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metabolites link (0)

br08003 Category	KEGG ID	KNApSAcK ID

Metabolite list (5)

KNApSAcK ID	name	ChEMBL link	CTD link	# of proteins in ChEMBL interaction / related OMIM / related KEGG DISEASE	# of genes in CTD interaction / related diseases	figure
C00001491	ATP / Adenosine triphosphate	CHEMBL14249	D000255	32 / 17 / 24	77 / 34
C00007223	GTP / Guanosine triphosphate	CHEMBL1201369 CHEMBL2311196	D006160	1 / 4 / 7	8 / 0
C00017575	Fosfadecin / Antibiotic TAN 930		C063720
C00019353	ADP / Adenosine 5'-diphosphate	CHEMBL14830	D000244	20 / 8 / 5	27 / 2
C00019639	CTP / Cytidine 5'-triphosphate	CHEMBL223533	D003570

Human Protein / Gene in interactions

43 ChEMBL Protein in interactions

accession	description	class description	KNApSAcK metabolite in interactions	# of diseases (OMIM / KEGG)
P08238	Heat shock protein HSP 90-beta	Other cytosolic protein	C00001491 C00019353	0 / 0
P11142	Heat shock cognate 71 kDa protein	Unclassified protein	C00001491 C00019353	0 / 0
P47900	P2Y purinoceptor 1	Purine receptor	C00001491 C00019353	0 / 0
P04406	Glyceraldehyde-3-phosphate dehydrogenase	Enzyme	C00001491 C00019353	0 / 0
P07900	Heat shock protein HSP 90-alpha	Other cytosolic protein	C00001491 C00019353	0 / 0
P51575	P2X purinoceptor 1	NS	C00001491 C00019353	0 / 0
Q15077	P2Y purinoceptor 6	Purine receptor	C00001491 C00019353	0 / 0
P56373	P2X purinoceptor 3	NS	C00001491 C00019353	0 / 0
P51582	P2Y purinoceptor 4	Purine receptor	C00001491 C00019353	0 / 0
P41231	P2Y purinoceptor 2	Purine receptor	C00001491 C00019353	0 / 0
P04183	Thymidine kinase, cytosolic	Enzyme	C00001491	0 / 1
P00519	Tyrosine-protein kinase ABL1	Abl	C00001491	1 / 2
Q8TD43	Transient receptor potential cation channel subfamily M member 4	Unclassified protein	C00019353	1 / 1
P22413	Ectonucleotide pyrophosphatase/phosphodiesterase family member 1	Enzyme	C00019353	4 / 4
P00533	Epidermal growth factor receptor	TK tyrosine-protein kinase EGFR subfamily	C00001491	1 / 8
P01112	GTPase HRas	Other cytosolic protein	C00007223	4 / 7
Q99571	P2X purinoceptor 4	NS	C00001491	0 / 0
P31751	RAC-beta serine/threonine-protein kinase	Akt	C00001491	2 / 2
Q9UBL9	P2X purinoceptor 2	NS	C00019353	0 / 0
Q96G91	P2Y purinoceptor 11	Purine receptor	C00001491	0 / 0
P27708	CAD protein	Enzyme	C00001491	0 / 0
P02545	Prelamin-A/C	Unclassified protein	C00001491	11 / 10
P43220	Glucagon-like peptide 1 receptor	Glucagon-like peptide receptor	C00001491	0 / 0
P32189	Glycerol kinase	Enzyme	C00001491	1 / 1
P08107	Heat shock 70 kDa protein 1A/1B	Unclassified protein	C00001491	0 / 0
P11021	78 kDa glucose-regulated protein	Unclassified protein	C00019353	0 / 0
Q9H244	P2Y purinoceptor 12	Purine receptor	C00001491	1 / 1
Q96GD4	Aurora kinase B	Aur	C00001491	0 / 0
P49137	MAP kinase-activated protein kinase 2	CAMK serine/threonine protein kinase MAPKAPK	C00001491	0 / 0
Q9BXA7	Testis-specific serine/threonine-protein kinase 1	Tssk	C00001491	0 / 0
Q99572	P2X purinoceptor 7	NS	C00001491	0 / 0
P52732	Kinesin-like protein KIF11	Other cytosolic protein	C00019353	1 / 0
O14965	Aurora kinase A	Aur	C00001491	0 / 0
O14757	Serine/threonine-protein kinase Chk1	Chk1	C00001491	0 / 0
Q15172	Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit alpha isoform	Protein phosphatase regulatory subunit	C00001491	0 / 0
Q9UBF8	Phosphatidylinositol 4-kinase beta	Enzyme	C00019353	0 / 0
Q8TCG2	Phosphatidylinositol 4-kinase type 2-beta	Enzyme	C00019353	0 / 0
Q9BTU6	Phosphatidylinositol 4-kinase type 2-alpha	Enzyme	C00019353	0 / 0
P42356	Phosphatidylinositol 4-kinase alpha	Enzyme	C00019353	0 / 0
P24864	G1/S-specific cyclin-E1	Other cytosolic protein	C00001491	0 / 2
P24941	Cyclin-dependent kinase 2	Cdc2	C00001491	0 / 0
O96020	G1/S-specific cyclin-E2	Other cytosolic protein	C00001491	0 / 2
P49798	Regulator of G-protein signaling 4	Unclassified protein	C00019353	2 / 0

106 Gene in CTD interactions

gene	gene name	gene description	KNApSAcK metabolite in interactions
1080	CFTR, ABC35, ABCC7, CF, CFTR/MRP, MRP7, TNR-CFTR, dJ760C5.1	cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49)	C00001491 C00019353
5536	PPP5C, PP5, PPP5, PPT	protein phosphatase 5, catalytic subunit (EC:3.1.3.16)	C00001491 C00019353
5595	MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK	mitogen-activated protein kinase 3 (EC:2.7.11.24)	C00001491 C00019353
5594	MAPK1, ERK, ERK2, ERT1, MAPK2, P42MAPK, PRKM1, PRKM2, p38, p40, p41, p41mapk	mitogen-activated protein kinase 1 (EC:2.7.11.24)	C00001491 C00019353
2597	GAPDH, G3PD, GAPD	glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12)	C00001491 C00019353
2147	F2, PT, RPRGL2, THPH1	coagulation factor II (thrombin) (EC:3.4.21.5)	C00001491 C00019353
5295	PIK3R1, AGM7, GRB1, p85, p85-ALPHA	phosphoinositide-3-kinase, regulatory subunit 1 (alpha)	C00001491
2244	FGB	fibrinogen beta chain	C00019353
2266	FGG	fibrinogen gamma chain	C00019353
1557	CYP2C19, CPCJ, CYP2C, P450C2C, P450IIC19	cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80)	C00019353
2621	GAS6, AXLLG, AXSF	growth arrest-specific 6	C00019353
3265	HRAS, C-BAS/HAS, C-H-RAS, C-HA-RAS1, CTLO, H-RASIDX, HAMSV, HRAS1, K-RAS, N-RAS, RASH1	Harvey rat sarcoma viral oncogene homolog	C00019353
3673	ITGA2, BR, CD49B, GPIa, HPA-5, VLA-2, VLAA2	integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor)	C00019353
3674	ITGA2B, BDPLT16, BDPLT2, CD41, CD41B, GP2B, GPIIb, GT, GTA, HPA3	integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41)	C00019353
3690	ITGB3, BDPLT16, BDPLT2, CD61, GP3A, GPIIIa, GT	integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)	C00019353
213	ALB, PRO0883, PRO0903, PRO1341	albumin	C00019353
959	CD40LG, CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L	CD40 ligand	C00019353
10461	MERTK, MER, RP38, c-mer	c-mer proto-oncogene tyrosine kinase (EC:2.7.10.1)	C00019353
4907	NT5E, CALJA, CD73, E5NT, NT, NT5, NTE, eN, eNT	5'-nucleotidase, ecto (CD73) (EC:3.1.3.5)	C00019353
64805	P2RY12, ADPG-R, BDPLT8, HORK3, P2T(AC), P2Y(12)R, P2Y(AC), P2Y(ADP), P2Y(cyc), P2Y12, SP1999	purinergic receptor P2Y, G-protein coupled, 12	C00019353
5155	PDGFB, IBGC5, PDGF-2, PDGF2, SIS, SSV, c-sis	platelet-derived growth factor beta polypeptide	C00019353
5196	PF4, CXCL4, PF-4, SCYB4	platelet factor 4	C00019353
5473	PPBP, B-TG1, Beta-TG, CTAP-III, CTAP3, CTAPIII, CXCL7, LA-PF4, LDGF, MDGF, NAP-2, PBP, SCYB7, TC1, TC2, TGB, TGB1, THBGB, THBGB1	pro-platelet basic protein (chemokine (C-X-C motif) ligand 7)	C00019353
558	AXL, JTK11, UFO	AXL receptor tyrosine kinase (EC:2.7.10.1)	C00019353
6403	SELP, CD62, CD62P, GMP140, GRMP, LECAM3, PADGEM, PSEL	selectin P (granule membrane protein 140kDa, antigen CD62)	C00019353
7057	THBS1, THBS, THBS-1, TSP, TSP-1, TSP1	thrombospondin 1	C00019353
7301	TYRO3, BYK, Dtk, RSE, Sky, Tif	TYRO3 protein tyrosine kinase (EC:2.7.10.1)	C00019353
10351	ABCA8	ATP-binding cassette, sub-family A (ABC1), member 8	C00001491
5243	ABCB1, ABC20, CD243, CLCS, GP170, MDR1, P-GP, PGY1	ATP-binding cassette, sub-family B (MDR/TAP), member 1 (EC:3.6.3.44)	C00001491
8647	ABCB11, ABC16, BRIC2, BSEP, PFIC-2, PFIC2, PGY4, SPGP	ATP-binding cassette, sub-family B (MDR/TAP), member 11	C00001491
4363	ABCC1, ABC29, ABCC, GS-X, MRP, MRP1	ATP-binding cassette, sub-family C (CFTR/MRP), member 1	C00001491
1244	ABCC2, ABC30, CMOAT, DJS, MRP2, cMRP	ATP-binding cassette, sub-family C (CFTR/MRP), member 2	C00001491
10257	ABCC4, EST170205, MOAT-B, MOATB, MRP4	ATP-binding cassette, sub-family C (CFTR/MRP), member 4	C00001491
368	ABCC6, ABC34, ARA, EST349056, GACI2, MLP1, MOAT-E, MOATE, MRP6, PXE, PXE1, URG7	ATP-binding cassette, sub-family C (CFTR/MRP), member 6	C00001491
25	ABL1, ABL, JTK7, bcr/abl, c-ABL, p150, v-abl	c-abl oncogene 1, non-receptor tyrosine kinase (EC:2.7.10.2)	C00001491
238	ALK, CD246, NBLST3	anaplastic lymphoma receptor tyrosine kinase (EC:2.7.10.1)	C00001491
538	ATP7A, DSMAX, MK, MNK, SMAX3	ATPase, Cu++ transporting, alpha polypeptide (EC:3.6.3.54)	C00001491
540	ATP7B, PWD, WC1, WD, WND	ATPase, Cu++ transporting, beta polypeptide (EC:3.6.3.54)	C00001491
596	BCL2, Bcl-2, PPP1R50	B-cell CLL/lymphoma 2	C00001491
613	BCR, ALL, BCR1, CML, D22S11, D22S662, PHL	breakpoint cluster region (EC:2.7.11.1)	C00001491
834	CASP1, ICE, IL1BC, P45	caspase 1, apoptosis-related cysteine peptidase (EC:3.4.22.36)	C00001491
836	CASP3, CPP32, CPP32B, SCA-1	caspase 3, apoptosis-related cysteine peptidase (EC:3.4.22.56)	C00001491
847	CAT	catalase (EC:1.11.1.6)	C00001491
26973	CHORDC1, CHP1	cysteine and histidine-rich domain (CHORD) containing 1	C00001491
1312	COMT	catechol-O-methyltransferase (EC:2.1.1.6)	C00001491
4514	COX3, COIII, MTCO3, MT-CO3	cytochrome c oxidase III	C00001491
1376	CPT2, CPT1, CPTASE, IIAE4	carnitine palmitoyltransferase 2 (EC:2.3.1.21)	C00001491
1399	CRKL	v-crk avian sarcoma virus CT10 oncogene homolog-like	C00001491
339221	ENPP7, ALK-SMase, E-NPP_7, NPP-7	ectonucleotide pyrophosphatase/phosphodiesterase 7 (EC:3.1.4.12)	C00001491
2688	GH1, GH, GH-N, GHN, IGHD1B, hGH-N	growth hormone 1	C00001491
2697	GJA1, AVSD3, CMDR, CX43, DFNB38, GJAL, HLHS1, HSS, ODDD	gap junction protein, alpha 1, 43kDa	C00001491
2950	GSTP1, DFN7, FAEES3, GST3, GSTP, PI	glutathione S-transferase pi 1 (EC:2.5.1.18)	C00001491
3383	ICAM1, BB2, CD54, P3.58	intercellular adhesion molecule 1	C00001491
3593	IL12B, CLMF, CLMF2, IL-12B, NKSF, NKSF2	interleukin 12B (natural killer cell stimulatory factor 2, cytotoxic lymphocyte maturation factor 2, p40)	C00001491
3606	IL18, IGIF, IL-18, IL-1g, IL1F4	interleukin 18 (interferon-gamma-inducing factor)	C00001491
3553	IL1B, IL-1, IL1-BETA, IL1F2	interleukin 1, beta	C00001491
3569	IL6, BSF2, HGF, HSF, IFNB2, IL-6	interleukin 6 (interferon, beta 2)	C00001491
3630	INS, IDDM2, ILPR, IRDN, MODY10	insulin	C00001491
26548	ITGB1BP2, CHORDC3, ITGB1BP, MELUSIN	integrin beta 1 binding protein (melusin) 2	C00001491
3772	KCNJ15, IRKK, KIR1.3, KIR4.2	potassium inwardly-rectifying channel, subfamily J, member 15	C00001491
3795	KHK	ketohexokinase (fructokinase) (EC:2.7.1.3)	C00001491
3991	LIPE, HSL, LHS	lipase, hormone-sensitive (EC:3.1.1.79)	C00001491
4023	LPL, HDLCQ11, LIPD	lipoprotein lipase (EC:3.1.1.34)	C00001491
55191	NADSYN1	NAD synthetase 1 (EC:6.3.5.1)	C00001491
114548	NLRP3, AGTAVPRL, AII, AVP, C1orf7, CIAS1, CLR1.1, FCAS, FCU, MWS, NALP3, PYPAF1	NLR family, pyrin domain containing 3	C00001491
9221	NOLC1, NOPP130, NOPP140, NS5ATP13, P130	nucleolar and coiled-body phosphoprotein 1	C00001491
4843	NOS2, HEP-NOS, INOS, NOS, NOS2A	nitric oxide synthase 2, inducible (EC:1.14.13.39)	C00001491
4852	NPY, PYY4	neuropeptide Y	C00001491
4938	OAS1, IFI-4, OIAS, OIASI	2'-5'-oligoadenylate synthetase 1, 40/46kDa (EC:2.7.7.84)	C00001491
5027	P2RX7, P2X7	purinergic receptor P2X, ligand-gated ion channel, 7	C00001491
5028	P2RY1, P2Y1	purinergic receptor P2Y, G-protein coupled, 1	C00001491
5032	P2RY11, P2Y11	purinergic receptor P2Y, G-protein coupled, 11	C00001491
53829	P2RY13, GPCR1, GPR86, GPR94, P2Y13, SP174	purinergic receptor P2Y, G-protein coupled, 13	C00001491
5029	P2RY2, HP2U, P2RU1, P2U, P2U1, P2UR, P2Y2, P2Y2R	purinergic receptor P2Y, G-protein coupled, 2	C00001491
5030	P2RY4, NRU, P2P, P2Y4, UNR	pyrimidinergic receptor P2Y, G-protein coupled, 4	C00001491
5031	P2RY6, P2Y6	pyrimidinergic receptor P2Y, G-protein coupled, 6	C00001491
24145	PANX1, MRS1, PX1, UNQ2529	pannexin 1	C00001491
142	PARP1, ADPRT, ADPRT_1, ADPRT1, ARTD1, PARP, PARP-1, PPOL, pADPRT-1	poly (ADP-ribose) polymerase 1 (EC:2.4.2.30)	C00001491
5290	PIK3CA, CLOVE, CWS5, MCAP, MCM, MCMTC, PI3K, p110-alpha	phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit alpha (EC:2.7.11.1 2.7.1.153)	C00001491
2243	FGA, Fib2	fibrinogen alpha chain	C00019353
5578	PRKCA, AAG6, PKC-alpha, PKCA, PRKACA	protein kinase C, alpha (EC:2.7.11.13)	C00001491
10928	RALBP1, RIP1, RLIP1, RLIP76	ralA binding protein 1	C00001491
5970	RELA, NFKB3, p65	v-rel avian reticuloendotheliosis viral oncogene homolog A	C00001491
6402	SELL, CD62L, LAM1, LECAM1, LEU8, LNHR, LSEL, LYAM1, PLNHR, TQ1	selectin L	C00001491
653509	SFTPA1, COLEC4, PSAP, PSP-A, PSPA, SFTP1, SFTPA1B, SP-A, SP-A1, SPA, SPA1	surfactant protein A1	C00001491
729238	SFTPA2, COLEC5, PSAP, PSP-A, PSPA, SFTP1, SFTPA2B, SP-A, SPA2, SPAII	surfactant protein A2	C00001491
9016	SLC25A14, BMCP1, UCP5	solute carrier family 25 (mitochondrial carrier, brain), member 14	C00001491
6513	SLC2A1, DYT17, DYT18, DYT9, EIG12, GLUT, GLUT1, GLUT1DS, HTLVR, PED	solute carrier family 2 (facilitated glucose transporter), member 1	C00001491
6528	SLC5A5, NIS, TDH1	solute carrier family 5 (sodium/iodide cotransporter), member 5	C00001491
6647	SOD1, ALS, ALS1, IPOA, SOD, hSod1, homodimer	superoxide dismutase 1, soluble (EC:1.15.1.1)	C00001491
10910	SUGT1, SGT1	SGT1, suppressor of G2 allele of SKP1 (S. cerevisiae)	C00001491
7124	TNF, DIF, TNF-alpha, TNFA, TNFSF2	tumor necrosis factor	C00001491
7153	TOP2A, TOP2, TP2A	topoisomerase (DNA) II alpha 170kDa (EC:5.99.1.3)	C00001491
7157	TP53, BCC7, LFS1, P53, TRP53	tumor protein p53	C00001491
7252	TSHB, TSH-B, TSH-BETA	thyroid stimulating hormone, beta	C00001491
7295	TXN, TRDX, TRX, TRX1	thioredoxin	C00001491
7351	UCP2, BMIQ4, SLC25A8, UCPH	uncoupling protein 2 (mitochondrial, proton carrier)	C00001491
7352	UCP3, SLC25A9	uncoupling protein 3 (mitochondrial, proton carrier)	C00001491
998	CDC42, CDC42Hs, G25K	cell division cycle 42	C00007223
2530	FUT8	fucosyltransferase 8 (alpha (1,6) fucosyltransferase) (EC:2.4.1.68)	C00007223
2993	GYPA, CD235a, GPA, GPErik, GPSAT, HGpMiV, HGpMiXI, HGpSta(C), MN, MNS, PAS-2	glycophorin A (MNS blood group)	C00007223
3269	HRH1, H1-R, hisH1	histamine receptor H1	C00007223
5879	RAC1, Rac-1, TC-25, p21-Rac1	ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1)	C00007223
5908	RAP1B, K-REV, RAL1B	RAP1B, member of RAS oncogene family	C00007223
387	RHOA, ARH12, ARHA, RHO12, RHOH12	ras homolog family member A	C00007223
7052	TGM2, G-ALPHA-h, GNAH, TG2, TGC	transglutaminase 2 (EC:2.3.2.13)	C00007223

Related Diseases

Diseases related to proteins in ChEMBL interactions

Diseases related to CTD interactions