KNApSAcK Metabolite C00019353
Metabolite
KNApSAcK Entry
| id | C00019353 |
|---|---|
| Name | ADP / Adenosine 5'-diphosphate |
| CAS RN | 58-64-0 |
| Standard InChI | InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20)/t4-,6?,7+,10-/m1/s1 |
| Standard InChI (Main Layer) | InChI=1S/C10H15N5O10P2/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(24-10)1-23-27(21,22)25-26(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H2,11,12,13)(H2,18,19,20) |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 2262 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer | CHEMBL14830 |
KEGG
| By LinkDB | C00008 |
|---|
CTD
| By CAS RN | D000244 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|---|
| Enterobacteriaceae | 1 |
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
| Escherichia coli | 562 | Enterobacteriaceae | Bacteria |
Human Protein / Gene in interaction
20 ChEMBL Protein in interactions
| accession | description | class description | compound | assay ID (# of activities) |
# of diseases
(OMIM / KEGG) |
|---|---|---|---|---|---|
| P49798 | Regulator of G-protein signaling 4 | Unclassified protein | CHEMBL14830 |
CHEMBL1794499
(1)
|
2 / 0 |
| P47900 | P2Y purinoceptor 1 | Purine receptor | CHEMBL14830 |
CHEMBL1067692
(1)
|
0 / 0 |
| P04406 | Glyceraldehyde-3-phosphate dehydrogenase | Enzyme | CHEMBL14830 |
CHEMBL1614063
(1)
|
0 / 0 |
| Q8TD43 | Transient receptor potential cation channel subfamily M member 4 | Unclassified protein | CHEMBL14830 |
CHEMBL1629243
(1)
|
1 / 1 |
| Q15077 | P2Y purinoceptor 6 | Purine receptor | CHEMBL14830 |
CHEMBL866173
(1)
CHEMBL867434
(1)
|
0 / 0 |
| P51582 | P2Y purinoceptor 4 | Purine receptor | CHEMBL14830 |
CHEMBL867437
(1)
|
0 / 0 |
| P56373 | P2X purinoceptor 3 | NS | CHEMBL14830 |
CHEMBL751806
(1)
|
0 / 0 |
| P22413 | Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 | Enzyme | CHEMBL14830 |
CHEMBL2182177
(1)
|
4 / 4 |
| Q9UBL9 | P2X purinoceptor 2 | NS | CHEMBL14830 |
CHEMBL759522
(1)
|
0 / 0 |
| P41231 | P2Y purinoceptor 2 | Purine receptor | CHEMBL14830 |
CHEMBL751765
(1)
CHEMBL867435
(1)
|
0 / 0 |
| P11021 | 78 kDa glucose-regulated protein | Unclassified protein | CHEMBL14830 |
CHEMBL1786486
(1)
CHEMBL1786489
(1)
|
0 / 0 |
| P52732 | Kinesin-like protein KIF11 | Other cytosolic protein | CHEMBL14830 |
CHEMBL1249439
(1)
CHEMBL1249440
(1)
|
1 / 0 |
| P51575 | P2X purinoceptor 1 | NS | CHEMBL14830 |
CHEMBL759509
(1)
|
0 / 0 |
| P07900 | Heat shock protein HSP 90-alpha | Other cytosolic protein | CHEMBL14830 |
CHEMBL867907
(1)
CHEMBL908048
(1)
|
0 / 0 |
| P11142 | Heat shock cognate 71 kDa protein | Unclassified protein | CHEMBL14830 |
CHEMBL1273373
(1)
CHEMBL1614143
(1)
|
0 / 0 |
| Q9UBF8 | Phosphatidylinositol 4-kinase beta | Enzyme | CHEMBL14830 |
CHEMBL758627
(1)
CHEMBL758630
(1)
|
0 / 0 |
| Q8TCG2 | Phosphatidylinositol 4-kinase type 2-beta | Enzyme | CHEMBL14830 |
CHEMBL758627
(1)
CHEMBL758630
(1)
|
0 / 0 |
| Q9BTU6 | Phosphatidylinositol 4-kinase type 2-alpha | Enzyme | CHEMBL14830 |
CHEMBL758627
(1)
CHEMBL758630
(1)
|
0 / 0 |
| P42356 | Phosphatidylinositol 4-kinase alpha | Enzyme | CHEMBL14830 |
CHEMBL758627
(1)
CHEMBL758630
(1)
|
0 / 0 |
| P08238 | Heat shock protein HSP 90-beta | Other cytosolic protein | CHEMBL14830 |
CHEMBL867907
(1)
|
0 / 0 |
CTD interaction (48)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D000244 | 213 |
ALB
PRO0883 PRO0903 PRO1341 |
albumin | Adenosine Diphosphate results in decreased secretion of ALB protein |
decreases secretion
|
protein |
17303692
|
| D000244 | 213 |
ALB
PRO0883 PRO0903 PRO1341 |
albumin | Aspirin inhibits the reaction [Adenosine Diphosphate results in decreased secretion of ALB protein] |
decreases reaction
/ decreases secretion |
protein |
17303692
|
| D000244 | 558 |
AXL
JTK11 UFO |
AXL receptor tyrosine kinase (EC:2.7.10.1) | AXL protein results in decreased susceptibility to Adenosine Diphosphate |
decreases response to substance
|
protein |
15733062
|
| D000244 | 959 |
CD40LG
CD154 CD40L HIGM1 IGM IMD3 T-BAM TNFSF5 TRAP gp39 hCD40L |
CD40 ligand | Adenosine Diphosphate results in increased expression of CD40LG protein |
increases expression
|
protein |
11297035
|
| D000244 | 959 |
CD40LG
CD154 CD40L HIGM1 IGM IMD3 T-BAM TNFSF5 TRAP gp39 hCD40L |
CD40 ligand | clopidogrel inhibits the reaction [Adenosine Diphosphate results in increased expression of CD40LG protein] |
decreases reaction
/ increases expression |
protein |
11297035
|
| D000244 | 1080 |
CFTR
ABC35 ABCC7 CF CFTR/MRP MRP7 TNR-CFTR dJ760C5.1 |
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) | Adenosine Diphosphate binds to and results in decreased activity of CFTR protein |
affects binding
/ decreases activity |
protein |
15684079
|
| D000244 | 1080 |
CFTR
ABC35 ABCC7 CF CFTR/MRP MRP7 TNR-CFTR dJ760C5.1 |
cystic fibrosis transmembrane conductance regulator (ATP-binding cassette sub-family C, member 7) (EC:3.6.3.49) | P(1),P(5)-di(adenosine-5'-)pentaphosphate inhibits the reaction [Adenosine Diphosphate binds to and results in decreased activity of CFTR protein] |
affects binding
/ decreases activity / decreases reaction |
protein |
15684079
|
| D000244 | 1557 |
CYP2C19
CPCJ CYP2C P450C2C P450IIC19 |
cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) | CYP2C19 gene affects the susceptibility to [Adenosine Diphosphate co-treated with clopidogrel] |
affects cotreatment
/ affects response to substance |
gene |
16772608
|
| D000244 | 1557 |
CYP2C19
CPCJ CYP2C P450C2C P450IIC19 |
cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) | CYP2C19 gene SNP affects the reaction [Adenosine Diphosphate results in increased expression of SELP protein] |
affects reaction
/ increases expression |
gene |
18394438
|
| D000244 | 1557 |
CYP2C19
CPCJ CYP2C P450C2C P450IIC19 |
cytochrome P450, family 2, subfamily C, polypeptide 19 (EC:1.14.13.48 1.14.13.49 1.14.13.80) | CYP2C19 gene SNP affects the susceptibility to [Adenosine Diphosphate co-treated with Arachidonic Acid] |
affects cotreatment
/ affects response to substance |
gene |
18004210
|
| D000244 | 2147 |
F2
PT RPRGL2 THPH1 |
coagulation factor II (thrombin) (EC:3.4.21.5) | F2 protein results in increased abundance of Adenosine Diphosphate |
increases abundance
|
protein |
15342215
|
| D000244 | 2147 |
F2
PT RPRGL2 THPH1 |
coagulation factor II (thrombin) (EC:3.4.21.5) | Quercetin inhibits the reaction [F2 protein results in increased abundance of Adenosine Diphosphate] |
decreases reaction
/ increases abundance |
protein |
15342215
|
| D000244 | 2147 |
F2
PT RPRGL2 THPH1 |
coagulation factor II (thrombin) (EC:3.4.21.5) | resveratrol inhibits the reaction [F2 protein results in increased abundance of Adenosine Diphosphate] |
decreases reaction
/ increases abundance |
protein |
15342215
|
| D000244 | 2243 |
FGA
Fib2 |
fibrinogen alpha chain | Adenosine Diphosphate results in increased secretion of FGA protein |
increases secretion
|
protein |
17303692
|
| D000244 | 2243 |
FGA
Fib2 |
fibrinogen alpha chain | Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of FGA protein] |
increases reaction
/ increases secretion |
protein |
17303692
|
| D000244 | 2244 |
FGB
|
fibrinogen beta chain | Adenosine Diphosphate results in decreased secretion of FGB protein |
decreases secretion
|
protein |
17303692
|
| D000244 | 2244 |
FGB
|
fibrinogen beta chain | Aspirin inhibits the reaction [Adenosine Diphosphate results in decreased secretion of FGB protein] |
decreases reaction
/ decreases secretion |
protein |
17303692
|
| D000244 | 2266 |
FGG
|
fibrinogen gamma chain | Adenosine Diphosphate results in increased secretion of FGG protein |
increases secretion
|
protein |
17303692
|
| D000244 | 2266 |
FGG
|
fibrinogen gamma chain | Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of FGG protein] |
increases reaction
/ increases secretion |
protein |
17303692
|
| D000244 | 2597 |
GAPDH
G3PD GAPD |
glyceraldehyde-3-phosphate dehydrogenase (EC:1.2.1.12) | Adenosine Diphosphate inhibits the reaction [[GAPDH protein co-treated with NAD co-treated with Glyceraldehyde 3-Phosphate co-treated with Glutathione] results in increased reduction of sodium arsenite analog] |
affects cotreatment
/ decreases reaction / increases reduction |
protein |
15788719
|
| D000244 | 2621 |
GAS6
AXLLG AXSF |
growth arrest-specific 6 | GAS6 protein results in increased susceptibility to Adenosine Diphosphate |
increases response to substance
|
protein |
15733062
|
| D000244 | 3265 |
HRAS
C-BAS/HAS C-H-RAS C-HA-RAS1 CTLO H-RASIDX HAMSV HRAS1 K-RAS N-RAS RASH1 |
Harvey rat sarcoma viral oncogene homolog | Adenosine Diphosphate binds to and affects the folding of HRAS protein |
affects binding
/ affects folding |
protein |
16388579
|
| D000244 | 3673 |
ITGA2
BR CD49B GPIa HPA-5 VLA-2 VLAA2 |
integrin, alpha 2 (CD49B, alpha 2 subunit of VLA-2 receptor) | ITGA2 gene SNP affects the susceptibility to [Aspirin co-treated with clopidogrel co-treated with Adenosine Diphosphate] |
affects cotreatment
/ affects response to substance |
gene |
16214444
|
| D000244 | 3674 |
ITGA2B
BDPLT16 BDPLT2 CD41 CD41B GP2B GPIIb GT GTA HPA3 |
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]] |
affects binding
/ decreases reaction / increases expression |
protein |
18404433
|
| D000244 | 3674 |
ITGA2B
BDPLT16 BDPLT2 CD41 CD41B GP2B GPIIb GT GTA HPA3 |
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]] |
affects binding
/ decreases reaction / increases expression |
protein |
18404433
|
| D000244 | 3674 |
ITGA2B
BDPLT16 BDPLT2 CD41 CD41B GP2B GPIIb GT GTA HPA3 |
integrin, alpha 2b (platelet glycoprotein IIb of IIb/IIIa complex, antigen CD41) | N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]] |
affects binding
/ decreases reaction / increases expression / increases reaction |
protein |
18404433
|
| D000244 | 3690 |
ITGB3
BDPLT16 BDPLT2 CD61 GP3A GPIIIa GT |
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]] |
affects binding
/ decreases reaction / increases expression |
protein |
18404433
|
| D000244 | 3690 |
ITGB3
BDPLT16 BDPLT2 CD61 GP3A GPIIIa GT |
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]] |
affects binding
/ decreases reaction / increases expression |
protein |
18404433
|
| D000244 | 3690 |
ITGB3
BDPLT16 BDPLT2 CD61 GP3A GPIIIa GT |
integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61) | N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of [ITGA2B protein binds to ITGB3 protein]]] |
affects binding
/ decreases reaction / increases expression / increases reaction |
protein |
18404433
|
| D000244 | 5594 |
MAPK1
ERK ERK2 ERT1 MAPK2 P42MAPK PRKM1 PRKM2 p38 p40 p41 p41mapk |
mitogen-activated protein kinase 1 (EC:2.7.11.24) | Adenosine Diphosphate results in increased phosphorylation of MAPK1 protein |
increases phosphorylation
|
protein |
15034929
|
| D000244 | 5595 |
MAPK3
ERK-1 ERK1 ERT2 HS44KDAP HUMKER1A P44ERK1 P44MAPK PRKM3 p44-ERK1 p44-MAPK |
mitogen-activated protein kinase 3 (EC:2.7.11.24) | Adenosine Diphosphate results in increased phosphorylation of MAPK3 protein |
increases phosphorylation
|
protein |
15034929
|
| D000244 | 10461 |
MERTK
MER RP38 c-mer |
c-mer proto-oncogene tyrosine kinase (EC:2.7.10.1) | MERTK protein results in increased susceptibility to Adenosine Diphosphate |
increases response to substance
|
protein |
15733062
|
| D000244 | 4907 |
NT5E
CALJA CD73 E5NT NT NT5 NTE eN eNT |
5'-nucleotidase, ecto (CD73) (EC:3.1.3.5) | Adenosine Diphosphate analog results in decreased activity of NT5E protein |
decreases activity
|
protein |
18404487
|
| D000244 | 64805 |
P2RY12
ADPG-R BDPLT8 HORK3 P2T(AC) P2Y(12)R P2Y(AC) P2Y(ADP) P2Y(cyc) P2Y12 SP1999 |
purinergic receptor P2Y, G-protein coupled, 12 | P2RY12 protein affects the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein] |
affects reaction
/ increases expression |
protein |
18404433
|
| D000244 | 64805 |
P2RY12
ADPG-R BDPLT8 HORK3 P2T(AC) P2Y(12)R P2Y(AC) P2Y(ADP) P2Y(cyc) P2Y12 SP1999 |
purinergic receptor P2Y, G-protein coupled, 12 | P2RY12 protein affects the susceptibility to Adenosine Diphosphate |
affects response to substance
|
protein |
11196645
|
| D000244 | 5155 |
PDGFB
IBGC5 PDGF-2 PDGF2 SIS SSV c-sis |
platelet-derived growth factor beta polypeptide | Adenosine Diphosphate results in increased secretion of PDGFB protein |
increases secretion
|
protein |
17303692
|
| D000244 | 5155 |
PDGFB
IBGC5 PDGF-2 PDGF2 SIS SSV c-sis |
platelet-derived growth factor beta polypeptide | Aspirin promotes the reaction [Adenosine Diphosphate results in increased secretion of PDGFB protein] |
increases reaction
/ increases secretion |
protein |
17303692
|
| D000244 | 5196 |
PF4
CXCL4 PF-4 SCYB4 |
platelet factor 4 | Adenosine Diphosphate results in increased secretion of PF4 protein |
increases secretion
|
protein |
19428933
|
| D000244 | 5473 |
PPBP
B-TG1 Beta-TG CTAP-III CTAP3 CTAPIII CXCL7 LA-PF4 LDGF MDGF NAP-2 PBP SCYB7 TC1 TC2 TGB TGB1 THBGB THBGB1 |
pro-platelet basic protein (chemokine (C-X-C motif) ligand 7) | Adenosine Diphosphate results in increased secretion of PPBP protein |
increases secretion
|
protein |
19428933
|
| D000244 | 5536 |
PPP5C
PP5 PPP5 PPT |
protein phosphatase 5, catalytic subunit (EC:3.1.3.16) | Adenosine Diphosphate binds to and affects the folding of PPP5C protein |
affects binding
/ affects folding |
protein |
23184943
|
| D000244 | 6403 |
SELP
CD62 CD62P GMP140 GRMP LECAM3 PADGEM PSEL |
selectin P (granule membrane protein 140kDa, antigen CD62) | cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein] |
decreases reaction
/ increases expression |
protein |
18404433
|
| D000244 | 6403 |
SELP
CD62 CD62P GMP140 GRMP LECAM3 PADGEM PSEL |
selectin P (granule membrane protein 140kDa, antigen CD62) | CYP2C19 gene SNP affects the reaction [Adenosine Diphosphate results in increased expression of SELP protein] |
affects reaction
/ increases expression |
protein |
18394438
|
| D000244 | 6403 |
SELP
CD62 CD62P GMP140 GRMP LECAM3 PADGEM PSEL |
selectin P (granule membrane protein 140kDa, antigen CD62) | Heparin promotes the reaction [Adenosine Diphosphate affects the localization of SELP protein] |
affects localization
/ increases reaction |
protein |
9740346
|
| D000244 | 6403 |
SELP
CD62 CD62P GMP140 GRMP LECAM3 PADGEM PSEL |
selectin P (granule membrane protein 140kDa, antigen CD62) | N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein] |
decreases reaction
/ increases expression |
protein |
18404433
|
| D000244 | 6403 |
SELP
CD62 CD62P GMP140 GRMP LECAM3 PADGEM PSEL |
selectin P (granule membrane protein 140kDa, antigen CD62) | N(6)-methyl-2'-deoxyadenosine 3',5'-diphosphate promotes the reaction [cangrelor inhibits the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein]] |
decreases reaction
/ increases expression / increases reaction |
protein |
18404433
|
| D000244 | 6403 |
SELP
CD62 CD62P GMP140 GRMP LECAM3 PADGEM PSEL |
selectin P (granule membrane protein 140kDa, antigen CD62) | P2RY12 protein affects the reaction [Adenosine Diphosphate analog results in increased expression of SELP protein] |
affects reaction
/ increases expression |
protein |
18404433
|
| D000244 | 7057 |
THBS1
THBS THBS-1 TSP TSP-1 TSP1 |
thrombospondin 1 | Adenosine Diphosphate results in increased secretion of THBS1 protein |
increases secretion
|
protein |
17303692
|
| D000244 | 7301 |
TYRO3
BYK Dtk RSE Sky Tif |
TYRO3 protein tyrosine kinase (EC:2.7.10.1) | TYRO3 protein results in increased susceptibility to Adenosine Diphosphate |
increases response to substance
|
protein |
15733062
|
Related Disease
Diseases related to proteins in ChEMBL interactions
OMIM (8)
| OMIM | preferred title | UniProt |
|---|---|---|
| #208000 | Arterial calcification, generalized, of infancy, 1; gaci1 |
P22413
|
| #125853 | Diabetes mellitus, noninsulin-dependent; niddm |
P22413
|
| #613312 | Hypophosphatemic rickets, autosomal recessive, 2; arhr2 |
P22413
|
| #152950 | Microcephaly with or without chorioretinopathy, lymphedema, or mental retardation; mclmr |
P52732
|
| %602475 | Ossification of the posterior longitudinal ligament of spine; opll |
P22413
|
| #604559 | Progressive familial heart block, type ib; pfhb1b |
Q8TD43
|
| #604906 | Schizophrenia 9; sczd9 |
P49798
|
| #181500 | Schizophrenia; sczd |
P49798
|
KEGG DISEASE (5)
| KEGG | disease name | UniProt |
|---|---|---|
| H00214 | Hypophosphatemic rickets |
P22413
(related)
|
| H00409 | Type II diabetes mellitus |
P22413
(related)
|
| H00431 | Ossification of the posterior longitudinal ligament of spine (OPLL) |
P22413
(related)
|
| H01002 | Generalized arterial calcification of infancy |
P22413
(related)
|
| H01263 | Progressive cardiac conduction defect (PCCD) |
Q8TD43
(related)
|