PCIDB

KNApSAcK Metabolite C00007223

Metabolite

KNApSAcK Entry

id C00007223
Name GTP / Guanosine triphosphate
CAS RN 86-01-1
Standard InChI InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)/t3-,5-,6-,9-/m1/s1
Standard InChI (Main Layer) InChI=1S/C10H16N5O14P3/c11-10-13-7-4(8(18)14-10)12-2-15(7)9-6(17)5(16)3(27-9)1-26-31(22,23)29-32(24,25)28-30(19,20)21/h2-3,5-6,9,16-17H,1H2,(H,22,23)(H,24,25)(H2,19,20,21)(H3,11,13,14,18)

Cluster

Phytochemical cluster
KCF-S cluster No. 2262

Link

ChEMBL

By standard InChI
By standard InChI Main Layer CHEMBL1201369 CHEMBL2311196

KEGG

By LinkDB C00044

CTD

By CAS RN D006160

Species

Summary

Plant class

class name count
rosids 1

Family

family name count
Brassicaceae 1
Enterobacteriaceae 1

List (2)

* NCBI
KNApSAcK organism *ID *family *plant class *kingdom
Arabidopsis thaliana 3702 Brassicaceae rosids Viridiplantae
Escherichia coli 562 Enterobacteriaceae Bacteria

Human Protein / Gene in interaction

1 ChEMBL Protein in interactions

accession description class description compound assay ID (# of activities) # of diseases
(OMIM / KEGG)
P01112 GTPase HRas Other cytosolic protein CHEMBL2311196 CHEMBL662923 (1) CHEMBL744342 (1)
4 / 7

CTD interaction (9)

compound gene gene name gene description interaction interaction type form reference
pmid
D006160 998 CDC42
CDC42Hs
G25K
cell division cycle 42 resveratrol promotes the reaction [CDC42 protein binds to Guanosine Triphosphate] affects binding
/ increases reaction
protein 15217905
D006160 998 CDC42
CDC42Hs
G25K
cell division cycle 42 risedronic acid results in increased abundance of [Guanosine Triphosphate binds to CDC42 protein] affects binding
/ increases abundance
protein 16734383
D006160 2530 FUT8
fucosyltransferase 8 (alpha (1,6) fucosyltransferase) (EC:2.4.1.68) Guanosine Triphosphate results in decreased activity of FUT8 protein decreases activity
protein 12770769
D006160 2993 GYPA
CD235a
GPA
GPErik
GPSAT
HGpMiV
HGpMiXI
HGpSta(C)
MN
MNS
PAS-2
glycophorin A (MNS blood group) Guanosine Triphosphate results in increased expression of GYPA protein increases expression
protein 17002868
D006160 3269 HRH1
H1-R
hisH1
histamine receptor H1 Guanosine Triphosphate analog affects the reaction [Histamine inhibits the reaction [Pyrilamine binds to HRH1 protein]] affects binding
/ affects reaction
/ decreases reaction
protein 2419744
D006160 5879 RAC1
Rac-1
TC-25
p21-Rac1
ras-related C3 botulinum toxin substrate 1 (rho family, small GTP binding protein Rac1) risedronic acid results in increased abundance of [Guanosine Triphosphate binds to RAC1 protein] affects binding
/ increases abundance
protein 16734383
D006160 5908 RAP1B
K-REV
RAL1B
RAP1B, member of RAS oncogene family [Pentoxifylline results in increased abundance of Cyclic AMP] results in increased abundance of [RAP1B protein binds to Guanosine Triphosphate] affects binding
/ increases abundance
protein 21693435
D006160 387 RHOA
ARH12
ARHA
RHO12
RHOH12
ras homolog family member A risedronic acid results in increased abundance of [Guanosine Triphosphate binds to RHOA protein] affects binding
/ increases abundance
protein 16734383
D006160 7052 TGM2
G-ALPHA-h
GNAH
TG2
TGC
transglutaminase 2 (EC:2.3.2.13) Guanosine Triphosphate binds to TGM2 protein affects binding
protein 15556610

Related Disease

Diseases related to proteins in ChEMBL interactions

OMIM (4)

OMIM preferred title UniProt
#109800 Bladder cancer P01112
#218040 Costello syndrome P01112
#163200 Schimmelpenning-feuerstein-mims syndrome; sfm P01112
#607464 Thyroid carcinoma, hurthle cell P01112

KEGG DISEASE (7)

KEGG disease name UniProt
H00022 Bladder cancer P01112 (related)
H00025 Penile cancer P01112 (related)
H00030 Cervical cancer P01112 (related)
H00032 Thyroid cancer P01112 (related)
H00040 Squamous cell carcinoma P01112 (related)
H00048 Hepatocellular carcinoma P01112 (related)
H00523 Noonan syndrome and related disorders P01112 (related)