KNApSAcK Metabolite C00001534
Metabolite
KNApSAcK Entry
| id | C00001534 |
|---|---|
| Name | Cyanocobalamin |
| CAS RN | 68-19-9 |
| Standard InChI | InChI=1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);;/q;;+5/p-2/t31-,34+,35+,36+,37-,41-,52?,53?,56+,57-,59+,60-,61-,62-;;/m0../s1 |
| Standard InChI (Main Layer) | InChI=1S/C62H90N13O14P.CN.Co/c1-29-20-39-40(21-30(29)2)75(28-70-39)57-52(84)53(41(27-76)87-57)89-90(85,86)88-31(3)26-69-49(83)18-19-59(8)37(22-46(66)80)56-62(11)61(10,25-48(68)82)36(14-17-45(65)79)51(74-62)33(5)55-60(9,24-47(67)81)34(12-15-43(63)77)38(71-55)23-42-58(6,7)35(13-16-44(64)78)50(72-42)32(4)54(59)73-56;1-2;/h20-21,23,28,31,34-37,41,52-53,56-57,76,84H,12-19,22,24-27H2,1-11H3,(H15,63,64,65,66,67,68,69,71,72,73,74,77,78,79,80,81,82,83,85,86);; |
Cluster
| Phytochemical cluster | |
|---|---|
| KCF-S cluster | No. 8893 |
Link
ChEMBL
| By standard InChI | |
|---|---|
| By standard InChI Main Layer |
KEGG
| By LinkDB | C02823 |
|---|
CTD
| By CAS RN | D014805 |
|---|
Species
Summary
Plant class
| class name | count |
|---|
Family
| family name | count |
|---|
List (1)
* NCBI
| KNApSAcK organism | *ID | *family | *plant class | *kingdom |
|---|---|---|---|---|
Human Protein / Gene in interaction
CTD interaction (15)
| compound | gene | gene name | gene description | interaction | interaction type | form |
reference
pmid |
|---|---|---|---|---|---|---|---|
| D014805 | 5826 |
ABCD4
ABC41 EST352188 MAHCJ P70R P79R PMP69 PXMP1L |
ATP-binding cassette, sub-family D (ALD), member 4 | ABCD4 protein affects the metabolism of Vitamin B 12 |
affects metabolic processing
|
protein |
22922874
|
| D014805 | 57412 |
AS3MT
CYT19 |
arsenic (+3 oxidation state) methyltransferase (EC:2.1.1.137) | Folic Acid promotes the reaction [Vitamin B 12 promotes the reaction [AS3MT protein results in increased methylation of Arsenic]] |
increases methylation
/ increases reaction |
protein |
20049124
|
| D014805 | 57412 |
AS3MT
CYT19 |
arsenic (+3 oxidation state) methyltransferase (EC:2.1.1.137) | Vitamin B 12 promotes the reaction [AS3MT protein results in increased methylation of Arsenic] |
increases methylation
/ increases reaction |
protein |
20049124
|
| D014805 | 1401 |
CRP
PTX1 |
C-reactive protein, pentraxin-related | [Folic Acid co-treated with Riboflavin co-treated with Vitamin B 6 co-treated with Vitamin B 12] results in decreased expression of CRP protein |
affects cotreatment
/ decreases expression |
protein |
16517955
|
| D014805 | 1401 |
CRP
PTX1 |
C-reactive protein, pentraxin-related | [Vitamin E co-treated with Ascorbic Acid co-treated with Folic Acid co-treated with Riboflavin co-treated with Vitamin B 6 co-treated with Vitamin B 12] results in decreased expression of CRP protein |
affects cotreatment
/ decreases expression |
protein |
16517955
|
| D014805 | 2524 |
FUT2
B12QTL1 SE SEC2 Se2 sej |
fucosyltransferase 2 (secretor status included) (EC:2.4.1.69) | FUT2 gene polymorphism affects the abundance of Vitamin B 12 |
affects abundance
|
gene |
18776911
|
| D014805 | 3039 |
HBA1
CD31 HBH |
hemoglobin, alpha 1 | Vitamin B 12 affects the expression of HBA1 protein modified form |
affects expression
|
protein |
2299304
|
| D014805 | 3039 |
HBA1
CD31 HBH |
hemoglobin, alpha 1 | Vitamin B 12 affects the glycosylation of HBA1 protein |
affects glycosylation
|
protein |
2299304
|
| D014805 | 4129 |
MAOB
|
monoamine oxidase B (EC:1.4.3.4) | Vitamin B 12 results in decreased activity of MAOB protein |
decreases activity
|
protein |
7430361
|
| D014805 | 25974 |
MMACHC
RP11-291L19.3 cblC |
methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria | MMACHC protein mutant form results in decreased metabolism of Vitamin B 12 |
decreases metabolic processing
|
protein |
19700356
|
| D014805 | 25974 |
MMACHC
RP11-291L19.3 cblC |
methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria | MMACHC protein results in increased metabolism of Vitamin B 12 |
increases metabolic processing
|
protein |
19700356
|
| D014805 | 25974 |
MMACHC
RP11-291L19.3 cblC |
methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria | Vitamin B 12 analog binds to MMACHC protein |
affects binding
|
protein |
19700356
|
| D014805 | 25974 |
MMACHC
RP11-291L19.3 cblC |
methylmalonic aciduria (cobalamin deficiency) cblC type, with homocystinuria | Vitamin B 12 binds to MMACHC protein |
affects binding
|
protein |
19700356
|
| D014805 | 4548 |
MTR
HMAG MS cblG |
5-methyltetrahydrofolate-homocysteine methyltransferase (EC:2.1.1.13) | Vitamin B 12 binds to MTR protein |
affects binding
|
protein |
17477549
|
| D014805 | 6948 |
TCN2
D22S676 D22S750 II TC TC_II TC-2 TC2 TCII |
transcobalamin II | TCN2 protein binds to and results in increased uptake of Vitamin B 12 |
affects binding
/ increases uptake |
protein |
14632784
|
Related Disease
Diseases related to CTD interactions
80 disease from interactions of metabolites
| MeSH disease | OMIM | compound | disease name | evidence type |
reference
pmid |
|---|---|---|---|---|---|
| D000380 | D014805 | Agranulocytosis |
marker/mechanism
|
6533326
|
|
| D000544 | D014805 | Alzheimer Disease |
marker/mechanism
therapeutic |
15607954
17116317 |
|
| D000707 | D014805 | Anaphylaxis |
marker/mechanism
|
5572387
|
|
| D000740 | D014805 | Anemia |
marker/mechanism
therapeutic |
523178
620384 749158 4055326 6812012 9713230 11505263 11979747 12187553 |
|
| D000748 | D014805 | Anemia, Macrocytic |
therapeutic
|
3948463
15355372 |
|
| D000749 | D014805 | Anemia, Megaloblastic |
marker/mechanism
therapeutic |
3057748
4169978 4627864 5984971 6685839 9001810 11182287 12772378 15559613 16353713 19556642 |
|
| D000752 | D014805 | Anemia, Pernicious |
marker/mechanism
therapeutic |
857850
5572387 6533326 9314271 11360403 13082065 |
|
| D001044 | D014805 | Aphonia |
marker/mechanism
|
5572387
|
|
| D001201 | D014805 | Ascites |
marker/mechanism
|
199903
|
|
| D001284 | D014805 | Atrophy |
therapeutic
|
23690582
|
|
| D001321 | D014805 | Autistic Disorder |
marker/mechanism
|
16297937
|
|
| D001791 | D014805 | Blood Platelet Disorders |
therapeutic
|
4632789
|
|
| D001925 | D014805 | Brain Damage, Chronic |
therapeutic
|
23690582
|
|
| D001928 | D014805 | Brain Diseases, Metabolic |
marker/mechanism
|
6965256
7270059 |
|
| D001986 | D014805 | Bronchial Spasm |
marker/mechanism
|
5572387
|
|
| D002279 | D014805 | Carcinoma 256, Walker |
marker/mechanism
|
199903
|
|
| D002386 | D014805 | Cataract |
therapeutic
|
11438049
|
|
| D002446 | D014805 | Celiac Disease |
marker/mechanism
|
11943958
|
|
| D002493 | D014805 | Central Nervous System Diseases |
marker/mechanism
|
9658486
|
|
| D003072 | D014805 | Cognition Disorders |
therapeutic
|
23690582
|
|
| D003161 | D014805 | Compartment Syndromes |
marker/mechanism
|
15181952
|
|
| D023903 | D014805 | Coronary Restenosis |
marker/mechanism
|
15215483
16489563 |
|
| D019965 | D014805 | Delirium, Dementia, Amnestic, Cognitive Disorders |
marker/mechanism
|
3972777
12269601 |
|
| D003704 | D014805 | Dementia |
marker/mechanism
|
2147278
7527320 8426046 14558247 20430233 |
|
| D003711 | D014805 | Demyelinating Diseases |
marker/mechanism
|
2835439
9088497 16530131 |
|
| D003866 | D014805 | Depressive Disorder |
marker/mechanism
|
7527320
18291301 |
|
| D003929 | D014805 | Diabetic Neuropathies |
marker/mechanism
|
4776668
|
|
| D004244 | D014805 | Dizziness |
marker/mechanism
|
5572387
|
|
| D003875 | D014805 | Drug Eruptions |
marker/mechanism
|
11792017
|
|
| D004342 | D014805 | Drug Hypersensitivity |
marker/mechanism
|
5572387
|
|
| D056486 | D014805 | Drug-Induced Liver Injury |
marker/mechanism
|
22166485
|
|
| D004417 | D014805 | Dyspnea |
marker/mechanism
|
5572387
|
|
| D004827 | D014805 | Epilepsy |
marker/mechanism
|
4169978
|
|
| D005128 | D014805 | Eye Diseases |
marker/mechanism
|
4159602
|
|
| D005234 | D014805 | Fatty Liver |
therapeutic
|
7445574
|
|
| D005235 | D014805 | Fatty Liver, Alcoholic |
therapeutic
|
20118189
|
|
| D006261 | D014805 | Headache |
marker/mechanism
|
5572387
|
|
| D006330 | D014805 | Heart Defects, Congenital |
marker/mechanism
|
17124548
|
|
| D006331 | D014805 | Heart Diseases |
marker/mechanism
|
22166485
|
|
| D016481 | D014805 | Helicobacter Infections |
therapeutic
|
11505263
|
|
| D006402 | D014805 | Hematologic Diseases |
marker/mechanism
|
17721351
|
|
| D006463 | D014805 | Hemolytic-Uremic Syndrome |
marker/mechanism
|
7842113
8060203 |
|
| D006712 | D014805 | Homocystinuria |
marker/mechanism
|
2044594
7842113 8060203 |
|
| D020138 | D014805 | HYPERHOMOCYSTEINEMIA |
marker/mechanism
therapeutic |
9710054
12598836 16397167 |
|
| D007024 | D014805 | Hypotension, Orthostatic |
therapeutic
|
2037751
9773064 |
|
| C538556 | D014805 | Imerslund-Grasbeck syndrome |
marker/mechanism
therapeutic |
538553
9001810 10719679 |
|
| D056784 | D014805 | Leukoencephalopathies |
marker/mechanism
|
12749323
|
|
| D008106 | D014805 | Liver Cirrhosis, Experimental |
therapeutic
|
18239293
|
|
| D008107 | D014805 | Liver Diseases |
marker/mechanism
|
6533326
|
|
| D008114 | D014805 | Liver Neoplasms, Experimental |
marker/mechanism
|
199903
|
|
| D008180 | D014805 | Lupus Erythematosus, Systemic |
marker/mechanism
|
17718048
|
|
| D008661 | D014805 | Metabolism, Inborn Errors |
therapeutic
|
11182287
|
|
| D018908 | D014805 | Muscle Weakness |
marker/mechanism
|
2044594
|
|
| D009133 | D014805 | Muscular Atrophy |
marker/mechanism
|
2044594
|
|
| D009188 | D014805 | Myelitis, Transverse |
marker/mechanism
|
11965427
|
|
| D009203 | D014805 | Myocardial Infarction |
marker/mechanism
|
17412321
|
|
| D009207 | D014805 | Myoclonus |
marker/mechanism
|
11182287
|
|
| D009369 | D014805 | Neoplasms |
therapeutic
|
1962580
|
|
| D009422 | D014805 | Nervous System Diseases |
marker/mechanism
|
2044594
4669617 6685839 |
|
| D009461 | D014805 | Neurologic Manifestations |
therapeutic
|
18291301
|
|
| D009902 | D014805 | Optic Neuritis |
therapeutic
|
4175520
|
|
| D010146 | D014805 | Pain |
therapeutic
|
11516431
|
|
| D010198 | D014805 | Pancytopenia |
therapeutic
|
11182287
|
|
| D020335 | D014805 | Paraparesis |
therapeutic
|
19821069
|
|
| D010523 | D014805 | Peripheral Nervous System Diseases |
marker/mechanism
|
2835439
7527320 7552481 9658486 16530131 |
|
| D011115 | D014805 | Polyneuropathies |
marker/mechanism
|
4776668
|
|
| D011602 | D014805 | Psychophysiologic Disorders |
therapeutic
|
4169978
|
|
| D051437 | D014805 | Renal Insufficiency |
marker/mechanism
|
22166485
|
|
| D012393 | D014805 | Rosacea |
marker/mechanism
|
11763399
|
|
| D012594 | D014805 | Scleroderma, Localized |
marker/mechanism
|
15355372
|
|
| D012851 | D014805 | Sinus Thrombosis, Intracranial |
therapeutic
|
18786290
|
|
| D013118 | D014805 | Spinal Cord Diseases |
marker/mechanism
therapeutic |
4776668
9164147 14626725 16361298 16970556 19821069 |
|
| D013182 | D014805 | Sprue, Tropical |
therapeutic
|
4951496
|
|
| D020521 | D014805 | Stroke |
therapeutic
|
16517955
|
|
| D052879 | D014805 | Subacute Combined Degeneration |
marker/mechanism
|
11785055
18472229 18653402 |
|
| D013927 | D014805 | Thrombosis |
marker/mechanism
|
4632789
|
|
| D014581 | D014805 | Urticaria |
marker/mechanism
|
5572387
11792017 |
|
| D054556 | D014805 | Venous Thromboembolism |
marker/mechanism
|
12598836
|
|
| D014786 | D014805 | Vision Disorders |
marker/mechanism
|
8220105
|
|
| D014806 | D014805 | Vitamin B 12 Deficiency |
therapeutic
|
3948463
13082065 |